Post List

  • July 3, 2015
  • 06:06 AM
  • 1 view

A new tissue-specific FLCN-deficient mouse model of renal tumourigenesis

by Danielle Stevenson in BHD Research Blog

Animal models can be useful for understanding disease pathology and as preclinical models for drug testing. As BHD patients develop renal cell carcinomas (RCCs) of varied histologies, associated with a loss of FLCN, BHD animal models could be used to study of a wide range of renal cancer subtypes. Current BHD mouse models include kidney-specific Flcn-knockouts (Chen et al., 2008, Baba et al., 2008) and ubiquitous knockouts (Hasumi et al., 2009, Hartman et al., 2009, Hudon et al., 2010). The form........ Read more »

Chen J, Huang D, Rubera I, Futami K, Wang P, Zickert P, Khoo SK, Dykema K, Zhao P, Petillo D.... (2015) Disruption of tubular Flcn expression as a mouse model for renal tumor induction. Kidney international. PMID: 26083655  

  • July 3, 2015
  • 06:02 AM
  • 1 view

5 Tips For Better Sleep

by Elisabeth Buhl Thubron in United Academics

Adding some ‘worry time’ to your day could work better than pills.... Read more »

  • July 3, 2015
  • 05:15 AM
  • 3 views

Here be values (in the brain): how the ventral striatum participates in decision-making

by Pierre Megevand in Neuroscience and Medicine

A new research article shows that the ventral striatum includes a representation of the value attributed to potential choices in a gambling task, and of the decision eventually reached.... Read more »

  • July 3, 2015
  • 04:56 AM
  • 4 views

Vitamin D metabolic gene variants and risk for autism

by Paul Whiteley in Questioning Answers

I was really rather happy to see the "preliminary evidence" reported by Rebecca Schmidt and colleagues [1] when it came to examining whether selected vitamin D metabolic gene variants might show linkage to autism spectrum disorder (ASD) based on data derived from the CHARGE initiative.For quite a while now I've discussed the various peer-reviewed science on the topic of vitamin D deficiency / insufficiency with autism in mind on this blog (see here and see here for example). Specifically, h........ Read more »

Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, & Tassone F. (2015) Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early human development, 91(8), 483-489. PMID: 26073892  

  • July 2, 2015
  • 06:50 PM
  • 9 views

You are here: Home › Injury › Foot Strike Pattern and Injury Rates Foot Strike Pattern and Injury Rates

by Craig Payne in Running Research Junkie

You are here: Home › Injury › Foot Strike Pattern and Injury Rates
Foot Strike Pattern and Injury Rates... Read more »

  • July 2, 2015
  • 12:57 PM
  • 14 views

Freezing single atoms to absolute zero with microwaves brings quantum technology closer

by Dr. Jekyll in Lunatic Laboratories

Physicists at the University of Sussex have found a way of using everyday technology found in kitchen microwaves and mobile telephones to bring quantum physics closer to helping solve enormous scientific problems that the most powerful of today’s supercomputers cannot even begin to embark upon.... Read more »

Weidt, S., Randall, J., Webster, S., Standing, E., Rodriguez, A., Webb, A., Lekitsch, B., & Hensinger, W. (2015) Ground-State Cooling of a Trapped Ion Using Long-Wavelength Radiation. Physical Review Letters, 115(1). DOI: 10.1103/PhysRevLett.115.013002  

  • July 2, 2015
  • 11:57 AM
  • 17 views

Digesting bread and pasta can release biologically active molecules

by Dr. Jekyll in Lunatic Laboratories

Biologically active molecules released by digesting bread and pasta can survive digestion and potentially pass through the gut lining, suggests new research. The study reveals the molecules released when real samples of bread and pasta are digested, providing new information for research into gluten sensitivity.... Read more »

  • July 2, 2015
  • 09:00 AM
  • 15 views

Why Should You Care How Bacteria Fight Viruses?

by Bill Sullivan in The 'Scope

Research into how bacteria fight viruses has spurred a revolution in genetic engineering referred to as "CRISPR". CRISPR provides unprecedented ways to easily modify the genome of any living creature, including humans.... Read more »

Garneau, J., Dupuis, M., Villion, M., Romero, D., Barrangou, R., Boyaval, P., Fremaux, C., Horvath, P., Magadán, A., & Moineau, S. (2010) The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature, 468(7320), 67-71. DOI: 10.1038/nature09523  

Horie, M., Honda, T., Suzuki, Y., Kobayashi, Y., Daito, T., Oshida, T., Ikuta, K., Jern, P., Gojobori, T., Coffin, J.... (2010) Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature, 463(7277), 84-87. DOI: 10.1038/nature08695  

Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R., Church, G., Corn, J., Daley, G., Doudna, J., Fenner, M.... (2015) A prudent path forward for genomic engineering and germline gene modification. Science, 348(6230), 36-38. DOI: 10.1126/science.aab1028  

  • July 2, 2015
  • 08:00 AM
  • 9 views

Want Better Group Performance? Try a Standing Meeting

by Jeremiah Stanghini in Jeremiah Stanghini

In keeping with the theme of “standing” being better for us from earlier this week, I thought I’d tackle another journal article discussing the merits of standing. This time, the research included participants well-beyond the 2nd and 3rd grade, but still used students … Continue reading →... Read more »

  • July 2, 2015
  • 02:34 AM
  • 28 views

Acute bipolar depression and immune alterations

by Paul Whiteley in Questioning Answers

"Individuals with acute bipolar depression show immune alterations. Some of the alterations are similar to those found in acute mania."That was the bottom line reported by Faith Dickerson and colleagues [1] following their analysis of blood samples provided by "82 individuals with acute bipolar depression, 147 with acute mania, and 280 controls." Looking for the presence of various antibodies to "human herpesviruses, gliadin, Toxoplasma gondii, and endogenous retroviruses as well as for C-reacti........ Read more »

Dickerson F, Katsafanas E, Schweinfurth LA, Savage CL, Stallings C, Origoni A, Khushalani S, Lillehoj E, & Yolken R. (2015) Immune alterations in acute bipolar depression. Acta psychiatrica Scandinavica. PMID: 26061032  

  • July 1, 2015
  • 11:59 PM
  • 29 views

Comparison of running injuries between shod and barefoot

by Craig Payne in Running Research Junkie

Comparison of running injuries between shod and barefoot ... Read more »

  • July 1, 2015
  • 02:19 PM
  • 39 views

New epigenetic mechanism revealed in brain cells

by Dr. Jekyll in Lunatic Laboratories

For decades, researchers in the genetics field have theorized that the protein spools around which DNA is wound, histones, remain constant in the brain, never changing after development in the womb. Now, researchers from the Icahn School of Medicine at Mount Sinai have discovered that histones are steadily replaced in brain cells throughout life – a process which helps to switch genes on and off.... Read more »

Maze, I., Wenderski, W., Noh, K., Bagot, R., Tzavaras, N., Purushothaman, I., Elsässer, S., Guo, Y., Ionete, C., Hurd, Y.... (2015) Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron, 87(1), 77-94. DOI: 10.1016/j.neuron.2015.06.014  

  • July 1, 2015
  • 02:16 PM
  • 29 views

Ethics in research: how to improve the integrity of scientists in their work

by SciELO in SciELO in Perspective

Scientific activity as a social enterprise must maintain its credibility. The Transparency and Openness Promotion (TOP) Guidelines are presented as a recent and innovative initiative for scientific journals, and as one of the ways to guard this social value. … Read More →... Read more »

Alberts, B., Cicerone, R., Fienberg, S., Kamb, A., McNutt, M., Nerem, R., Schekman, R., Shiffrin, R., Stodden, V., Suresh, S.... (2015) Self-correction in science at work. Science, 348(6242), 1420-1422. DOI: 10.1126/science.aab3847  

Nosek, B., Alter, G., Banks, G., Borsboom, D., Bowman, S., Breckler, S., Buck, S., Chambers, C., Chin, G., Christensen, G.... (2015) Promoting an open research culture. Science, 348(6242), 1422-1425. DOI: 10.1126/science.aab2374  

  • July 1, 2015
  • 09:39 AM
  • 24 views

Video Tip of the Week: MorphoGraphX, morphogenesis in 4D

by Mary in OpenHelix

This week’s Video Tip of the Week covers a different aspect of bioinformatics than some of our other tips. But having been trained as a cell biologist, I do consider imaging software as an important part of the crucial software ecosystem. Also, since it’s a holiday week and traffic may be light in the US, […]... Read more »

Barbier de Reuille, P., Routier-Kierzkowska, A., Kierzkowski, D., Bassel, G., Schüpbach, T., Tauriello, G., Bajpai, N., Strauss, S., Weber, A., Kiss, A.... (2015) MorphoGraphX: A platform for quantifying morphogenesis in 4D. eLife. DOI: 10.7554/eLife.05864  

  • July 1, 2015
  • 08:30 AM
  • 29 views

Thinking Asymmetrically About Hormones

by Mark Lasbury in As Many Exceptions As Rules

Your endocrine glands are stimulated or suppressed by hormones. They in turn dump hormones into the blood. Blood goes everywhere equally. So why is your left adrenal gland bigger than your right? And why is the size difference larger in domesticated foxes as opposed to wild foxes? For that matter, why is the size of the right lobe of your thyroid gland depend on which hand you use to write!?... Read more »

Trut LN, Prasolova LA, Kharlamova AV, & Plyusnina IZ. (2002) Directional left-sided asymmetry of adrenals in experimentally domesticated animals. Bulletin of experimental biology and medicine, 133(5), 506-9. PMID: 12420075  

Hojaij, F., Vanderlei, F., Plopper, C., Rodrigues, C., Jácomo, A., Cernea, C., Oliveira, L., Marchi, L., & Brandão, L. (2011) Parathyroid gland anatomical distribution and relation to anthropometric and demographic parameters: a cadaveric study. Anatomical Science International, 86(4), 204-212. DOI: 10.1007/s12565-011-0111-0  

  • July 1, 2015
  • 06:24 AM
  • 37 views

Offspring autism risk and advancing parental age (differences)

by Paul Whiteley in Questioning Answers

Parental age at offspring conception/birth in relation to offspring autism risk has been a recurrent theme in autism research circles for quite a few years now. I've covered it more than once on this blog (see here for example) and the various suggestions that advancing parental age in particular, might elevate the risk of offspring autism.Set in this context, the paper by Sven Sandin and colleagues [1] (open-access) (a name not unfamiliar to this blog) adds to the research evidence based on the........ Read more »

Sandin S, Schendel D, Magnusson P, Hultman C, Surén P, Susser E, Grønborg T, Gissler M, Gunnes N, Gross R.... (2015) Autism risk associated with parental age and with increasing difference in age between the parents. Molecular psychiatry. PMID: 26055426  

  • July 1, 2015
  • 01:43 AM
  • 62 views

Technologies and Generations

by Aurametrix team in Health Technologies

Children no longer obey their parents; every man wants to write a book and the end of the world is evidently approaching. So said a clay tablet inscribed almost 5 thousand years ago. But the world still stands, although we do go through golden and dark ages and societies rise and fall. Technology's golden age is now. or so we hope. How are current generations influenced by it and how will they shape the future world? Even as they age, Baby Boomers embrace emerging technologies such as smartphone........ Read more »

Costanza, D., Badger, J., Fraser, R., Severt, J., & Gade, P. (2012) Generational Differences in Work-Related Attitudes: A Meta-analysis. Journal of Business and Psychology, 27(4), 375-394. DOI: 10.1007/s10869-012-9259-4  

Becton, J., Walker, H., & Jones-Farmer, A. (2014) Generational differences in workplace behavior. Journal of Applied Social Psychology, 44(3), 175-189. DOI: 10.1111/jasp.12208  

  • July 1, 2015
  • 12:05 AM
  • 38 views

The Power of the Mind May not be as Well Utilized as it could be

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Of 1283 survey respondents, only 27% of athletes reported using mental skills such as goal setting, positive self-talk, imagery, and relaxation. Of the 249 respondents who used mental skills 72% reported they felt it helped expedite their recovery process.... Read more »

Arvinen-Barrow M, Clement D, Hamson-Utley JJ, Zakrajsek RA, Lee SM, Kamphoff C, Lintunen T, Hemmings B, & Martin SB. (2015) Athletes' use of mental skills during sport injury rehabilitation. Journal of Sport Rehabilitation, 24(2), 189-97. PMID: 25996227  

  • June 30, 2015
  • 11:14 PM
  • 33 views

Surface matters: using earth-abundant materials to split water for energy storage

by Jonathan Trinastic in Goodnight Earth

Scientists have developed a new way to grow hematite as an electrode in solar water-splitting devices to greatly improve efficiency!... Read more »

Jang, J., Du, C., Ye, Y., Lin, Y., Yao, X., Thorne, J., Liu, E., McMahon, G., Zhu, J., Javey, A.... (2015) Enabling unassisted solar water splitting by iron oxide and silicon. Nature Communications, 7447. DOI: 10.1038/ncomms8447  

  • June 30, 2015
  • 08:12 PM
  • 28 views

Mongolian on the market

by Gegentuul Baioud in Language on the Move

Last week when I saw in my friends’ Wechat group an advertisement for delicately made Mongolian yurts, I thought of an article I had read earlier written by Mongolian scholar Naran Bilik. In his paper about urbanized Mongolians Bilik writes: … Continue reading →... Read more »

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