Today my friend Nicholas Sansbury Smith releases Extinction Edge, the sequel to Extinction Horizon, a sci-fi thriller where humanity is driven to extinction by a lethal virus. I posted an interview with Nick for the release of his first book, but today I wanted to talk about the science behind his premise: can a virus induce epigenetic changes?In a way, Nick's premise is similar to the premise I used in Chimeras: a large part of our DNA is made of pseudogenes, which are ancient genes that are no........ Read more »
Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U, & Scott RS. (2014) Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes. Journal of virology, 88(19), 11442-58. PMID: 25056883
Tian Y, Yang W, Song J, Wu Y, & Ni B. (2013) Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis. Molecular and cellular biology, 33(15), 2810-6. PMID: 23716588
Rongrui L, Na H, Zongfang L, Fanpu J, & Shiwen J. (2014) Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis. Current pharmaceutical design, 20(11), 1715-25. PMID: 23888939
Mbonye U, & Karn J. (2011) Control of HIV latency by epigenetic and non-epigenetic mechanisms. Current HIV research, 9(8), 554-67. PMID: 22211660
The paper from Katarina Babinská and colleagues  (open-access here) presents an interesting, if preliminary take on two potentially important issues linked to at least some cases of autism: gastrointestinal (GI) issues and inflammation (see here and see here respectively).Detailing the examination of plasma levels of a compound called high mobility group box 1 protein (HMGB1), a protein which has the apparent ability to 'bend DNA' and has some pretty potent immune effects  (one paper........ Read more »
Babinská K, Bucová M, Ďurmanová V, Lakatošová S, Jánošíková D, Bakoš J, Hlavatá A, & Ostatníková D. (2015) Increased plasma levels of the high mobility group box 1 protein (HMGB1) are associated with a higher score of gastrointestinal dysfunction in individuals with autism. Physiological research / Academia Scientiarum Bohemoslovaca. PMID: 25669692
Multi-voxel pattern analysis (MVPA) is an increasingly popular approach for analyzing the results of fMRI scanning experiments that measure brain activity. MVPA searches for patterns of activation that correlate with a particular mental state. This is called 'decoding' neural activity.
Now a new paper in the Journal of Neuroscience from Caltech neuroscientists Julien Dubois et al. reports that MVPA is unable to decode certain kinds of information, even though single-unit recordings confirm th... Read more »
Dubois J, de Berker AO, & Tsao DY. (2015) Single-Unit Recordings in the Macaque Face Patch System Reveal Limitations of fMRI MVPA. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2791-802. PMID: 25673866
Strategies and practices to achieve supply chain resilience have been at the heart of supply chain management practice and research for almost a decade. However, such efforts have often focused on ways to make supply chains more reactive to turbulence and disruptions. In our recent article, Antecedents and Dimensions of Supply Chain Robustness, my co-authors, Christian […]... Read more »
Durach, C., Wieland, A., & Machuca, J. (2015) Antecedents and Dimensions of Supply Chain Robustness: A Systematic Literature Review. International Journal of Physical Distribution , 45(1/2), 118-137. DOI: 10.1108/IJPDLM-05-2013-0133
The Tau-A biomarker is a potential biomarker to distinguish those at risk for prolonged recovery following a concussion.... Read more »
Shahim P, Linemann T, Inekci D, Karsdal MA, Blennow K, Tegner Y, Zetterberg H, & Henriksen K. (2015) Serum tau fragments predict return to play in concussed professional ice hockey players. Journal of Neurotrauma. PMID: 25621407
Many Cambrian fossils are simply spines and sclerites unassociated with any body. Few of the exceptionally-preserved Cambrian freaks come with spines attached, and some of the most prominent of these are the chancelloriids. Originally described as sponges by Charles Doolittle Walcott back in 1920 (Walcott, 1920), modern researchers have found that the spines are very similar to those […]
The post Chancelloriids Revised appeared first on Teaching Biology.
... Read more »
Stefan Bengtson, & Desmond Collins. (2015) Chancelloriids of the Cambrian Burgess Shale. Palaeontologia Electronica. info:other/
Think of it as interval training for the dinner table. Proponents of fasting style diets will be first to tell you there are health benefits, heck we've even covered some of the science here at the labs. Well new research shows that putting people on a intermittent fasting (or IF) diet may mimic some of the benefits of actual fasting, and that (ironically enough given their popularity) adding antioxidant supplements counteracts those benefits.... Read more »
Wegman, M., Guo, M., Bennion, D., Shankar, M., Chrzanowski, S., Goldberg, L., Xu, J., Williams, T., Lu, X., Hsu, S.... (2014) Practicality of Intermittent Fasting in Humans and its Effect on Oxidative Stress and Genes Related to Aging and Metabolism. Rejuvenation Research, 2147483647. DOI: 10.1089/rej.2014.1624
Babies link the sound of a word with the image of an object in their early learning of language and this is an important ability. How do they come to have this mechanism? Are there predispositions to making links between sounds and images? Research by Asano and others (citation below) shows one type of link. […]... Read more »
Asano, M., Imai, M., Kita, S., Kitajo, K., Okada, H., & Thierry, G. (2015) Sound symbolism scaffolds language development in preverbal infants. Cortex, 196-205. DOI: 10.1016/j.cortex.2014.08.025
I want to bring the paper from Tea Skaaby and colleagues  to your attention for today's brief blog post and their observation that there may be: "a possible protective role of a higher vitamin D status on autoimmune disease". Autoimmune disease by the way, reflects a breakdown in communication and tolerance of 'self' whereby the body attacks healthy tissue.Their findings, based on an analysis of "a total of 12,555 individuals from three population-based studies with measurements of vitam........ Read more »
Skaaby T, Husemoen LL, Thuesen BH, & Linneberg A. (2015) Prospective population-based study of the association between vitamin D status and incidence of autoimmune disease. Endocrine. PMID: 25666936
In my last post I started writing about the next step a coding student can take after learning the basics. This next step is of course learning not just to code, but to code responsibly. Last time I talked about using version control to keep track of code changes as you work through a project. For this next post, I want to take the conversation further by discussing...... Read more »
Life as we know it, when we peer deep into the vastness of space we look for someone — or something — that resembles ourselves. Carbon based, needs water lifeforms, but what if we’re being narrow-minded? A new type of methane-based, oxygen-free life form that can metabolize and reproduce similar to life on Earth has been modeled by a team of researchers suggests we are being too closed minded about life.... Read more »
James Stevenson,, Jonathan Lunine,, & Paulette Clancy. (2015) Membrane alternatives in worlds without oxygen: Creation of an azotosome. Science Advances. info:/http://dx.doi.org/10.1126/sciadv.1400067
Dear Alice’s fan, this poem by Shel Silverstein is titled ‘Alice’ and now it’s your turn: are you ready to go down the rabbit hole again and be guided in our mind’s wonderland? So, let’s see what the blow up-potion and the shrinking-cake are made of.... Read more »
Kuo YT, Chiu NC, Shen EY, Ho CS, & Wu MC. (1998) Cerebral perfusion in children with Alice in Wonderland syndrome. Pediatric neurology, 19(2), 105-8. PMID: 9744628
Odumade OA, Hogquist KA, & Balfour HH Jr. (2011) Progress and problems in understanding and managing primary Epstein-Barr virus infections. Clinical microbiology reviews, 24(1), 193-209. PMID: 21233512
MedicalResearch.com Interview with: Dr. Simonetta Genovesi MD Department of Health Science University of Milano-Bicocca, Monza Italy Nephrology Unit San Gerardo Hospital, Monza, Italy MedicalResearch: What is the background for this study? Dr. Genovesi: The prevalence of atrial fibrillation (AF) in … Continue reading →... Read more »
MedicalResearch.com Interview with:, & Dr. Simonetta Genovesi MD. (2015) Study Weighs Risks/Benefits of Oral Anticoagulation for Atrial Fibrillation in Hemodialysis Patients. MedicalResearch.com. info:/
MedicalResearch.com Interview with: William Mair, Ph.D Assistant Professor Department of Genetics and Complex Diseases Harvard T. H Chan School of Public Health Boston, MA 02115 MedicalResearch: What is the background for this study? What are the main findings? Dr. Mair: Dietary … Continue reading →... Read more »
MedicalResearch.com Interview with:, & William Mair, Ph.D. (2015) Cellular Energy Sensor Links Calorie Restriction With Healthy Aging. MedicalResearch.com. info:/
by Abel Molina in Evolutionary Games Group
There are some situations, perhaps lucky ones, where it is felt that an activity needs no external motivation or justification. For the rest, it can be helpful to think of what the task at hand can be useful for. This of course doesn’t answer the larger question of what is worth doing, since it just distributes […]... Read more »
Barton, N.H., Novak, S., & Paixão, T. (2014) Diverse forms of selection in evolution and computer science. Proceedings of the National Academy of Sciences of the United States of America, 111(29), 10398-9. PMID: 25009183
MedicalResearch.com Interview Invitation Frank Struyf MD PhD Director, Lead Clinical Development HPV vaccines at GlaxoSmithKline Biologicals GlaxoSmithKline Vaccines, Rixensart, Belgium MedicalResearch: What is the background for this study? What are the main findings? Dr. Struyf: Cervical cancer is the fourth … Continue reading →... Read more »
MedicalResearch.com Interview Invitation, & Frank Struyf MD PhD. (2015) HPV-16/18 Vaccine Provides Some Cross Protection To Other Cancer-Causing Subtypes. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Shyamasundaran Kottilil MBBS, PhD Division of Infectious Diseases, Institute of Human Virology, University of Maryland, Baltimore Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Medical Research: What is the … Continue reading →... Read more »
MedicalResearch.com Interview with:, & Shyamasundaran Kottilil MBBS, PhD. (2015) Oral Medication For Hepatitis C- HIV Combined Infection. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Nisha Bansal MD MAS Assistant Professor Associate Program Director for Research Kidney Research Institute Division of Nephrology University of Washington Medical Research: What is the background for this study? What are the main findings? Dr. Bansal: We … Continue reading →... Read more »
MedicalResearch.com Interview with:, & Nisha Bansal MD MAS Assistant Professor. (2015) Equation Helps Predict Mortality In Elderly Patients With Chronic Kidney Disease. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Professor Daniela Jakubowicz MD Diabetes Unit. E. Wolfson Medical Center Sackler Faculty of Medicine, Tel Aviv University and Tel Aviv Medical Center Israel MedicalResearch: What is the background for this study? What are the main findings? Professor … Continue reading →... Read more »
MedicalResearch.com Interview with:, & Professor Daniela Jakubowicz MD. (2015) Bigger Breakfast, Smaller Dinner May Improve Glycemic Control. MedicalResearch.com. info:/
In an interesting short paper just published in Trends in Cognitive Science, Caltech neuroscientist Ralph Adolphs offers his thoughts on The Unsolved Problems of Neuroscience.
Here's Adolphs' list of the top 23 questions (including 3 "meta" issues), which, he says, was inspired by Hilbert's famous set of 23 mathematical problems:
Problems that are solved, or soon will be:
I. How do single neurons compute?
II. What is the connectome of a small nervous system, like that of Caenorhabi... Read more »
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