Post List

  • November 20, 2014
  • 04:21 PM
  • 10 views

Designing a better flu vaccine

by Gabriel in Lunatic Laboratories

We all hate getting sick and the seasonal flu vaccine can help prevent a time of serious illness. Unfortunately the vaccine is usually an educated guess as to which strains of the flu are going to be most prevalent that year. Well now an international team of researchers has shown that it may be possible to improve the effectiveness of the seasonal flu vaccine by 'pre-empting' the evolution of the influenza virus.... Read more »

Fonville, J., Wilks, S., James, S., Fox, A., Ventresca, M., Aban, M., Xue, L., Jones, T., Le N. M. H., ., Pham Q. T., .... (2014) Antibody landscapes after influenza virus infection or vaccination. Science, 346(6212), 996-1000. DOI: 10.1126/science.1256427  

  • November 20, 2014
  • 11:49 AM
  • 17 views

Living Kidney Donor Consent Forms Don’t Make It Easy to Opt-Out

by Cristy at Living Donor 101 in Living Donors Are People Too

  These researchers’ abstract pretty much says it all (emphasis mine): Ethicists and guidelines have suggested that potential living kidney donors who withdraw from evaluation be offered an ‘alibi.’ We sought to determine what potential living kidney donors are told about their ability to opt out, alibi availability and postwithdrawal confidentiality. We reviewed 148 consent …
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The post Living Kidney Donor Consent Forms Don’t Make It Easy to Opt........ Read more »

  • November 20, 2014
  • 05:30 AM
  • 34 views

Intestinal permeability: an emerging scientific area (also with autism in mind)

by Paul Whiteley in Questioning Answers

What is the intestinal barrier? What is intestinal permeability? What factors affect the permeability of the intestinal barrier? How do you measure intestinal permeability? How might [altered] intestinal permeability link to health, well-being and various clinical diagnoses?The new triad @ Bischoff SC et al. 2014These are some of the questions tackled by the excellent open-access review by Stephan Bischoff and colleagues [1] which I would like to draw your attention to i........ Read more »

Bischoff, S., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J., Serino, M., Tilg, H., Watson, A., & Wells, J. (2014) Intestinal permeability - a new target for disease prevention and therapy. BMC Gastroenterology, 14(1), 189. DOI: 10.1186/s12876-014-0189-7  

  • November 20, 2014
  • 12:05 AM
  • 33 views

To Remove or not to Remove? That is the Question When Dealing with CPR Emergencies in Football

by Daniel Wager and Erin Oliver in Sports Medicine Research (SMR): In the Lab & In the Field

Football shoulder pads create a barrier for a rescuer who has to perform cardiopulmonary resuscitation on an athlete who is suffering from sudden cardiac arrest (SCA). Performing chest compressions under the shoulder pads, which increases compression depth, may be more effective in saving an SCA victim’s life.... Read more »

  • November 19, 2014
  • 06:44 PM
  • 15 views

Laundering your nanoparticle-coated socks: dangerous to fish?

by Megan Cartwright in Science-Based Writing

Your expensive new workout socks may be toxic—at least, if you are a tiny fish* downstream from the washing machines used to wash those socks! Researchers from Purdue University found that the silver nanoparticles added to socks to prevent bacterial … Continue reading →... Read more »

Gao J, Sepúlveda MS, Klinkhamer C, Wei A, Gao Y, & Mahapatra CT. (2014) Nanosilver-coated socks and their toxicity to zebrafish (Danio rerio) embryos. Chemosphere, 948-952. PMID: 25303653  

  • November 19, 2014
  • 03:43 PM
  • 71 views

Religious and paranormal believers are high in empathy – but confused about how the world works

by Tom Rees in Epiphenom

There’s a strand of thought that says that belief in the supernatural is founded upon a misunderstanding of how the world works (see: You either believe in it all, or you don’t). On the other hand, there’s another perspective that says the cognitive problem is with the atheists. Belief in gods, according to this school [Read More...]

... Read more »

  • November 19, 2014
  • 03:10 PM
  • 76 views

The real reason why new pop music is so incredibly bad

by Richard Kunert in Brain's Idea

You have probably heard that Pink Floyd recently published their new album Endless River. Will this bring back the wonderful world of good music after the endless awfulness of the popular music scene in the last 20 years or so? Is good music, as we know it from the 60s and 70s, back for good? […]... Read more »

  • November 19, 2014
  • 02:24 PM
  • 52 views

How gut microbiota changes the blood-brain barrier

by Gabriel in Lunatic Laboratories

Don’t be alarmed, but we are outnumbered. When figuring out what makes us, “us” we need to remember that there are far more bacteria genes in us than human genes, by recent counts it’s something like 360 to 1. We also know that your stomach can change your cravings, but now we know that your stomach affects more than just your thoughts. Your stomach can control what can get to your brain.... Read more »

Viorica Braniste, Maha Al-Asmakh, Czeslawa Kowal, Farhana Anuar, Afrouz Abbaspour, Miklós Tóth, Agata Korecka, Nadja Bakocevic, Ng Lai Guan, Parag Kundu.... (2014) The gut microbiota influences blood-brain barrier permeability in mice. Science Translational Medicine. info:/10.1126/scitranslmed.3009759

  • November 19, 2014
  • 10:33 AM
  • 58 views

Video: Seals Caught Raping Penguins !

by beredim in Strange Animals

Someone's having a really bad day!In a study published a few days ago, researchers from the Mammal Research Institute at the University of Pretoria, South Africa reported three incidents of fur seals (Aptenodytes patagonicus) sexually harassing and coercing with king penguins!The authors even took footage of the large mammals forcefully putting the birds to the ground and attempting to mate with them! The incidents took place at the sub-Antarctic Marion Island, on Goodhope Bay and Funk beach.The........ Read more »

  • November 19, 2014
  • 09:56 AM
  • 42 views

November 19, 2014

by Erin Campbell in HighMag Blog

You might not be able to get rid of the bad guys, but you can still win the battle if you cripple their mobility. Today’s image is from a paper describing how a tumor’s microenvironment can predict the motility of individual tumor cells. Metastasis is the spread of cancer cells throughout the body. The motility of tumor cells depends on the microenvironment around them, and a recent paper systematically looks at how that microenvironment can predict or alter the behavior of tumor cells. ........ Read more »

  • November 19, 2014
  • 09:53 AM
  • 43 views

Mongoose Lookouts Carefully Weigh Risks (and Sing While They Do It)

by Elizabeth Preston in Inkfish

If you were assigned to watch a dozen dwarf mongooses on the savannah, would you know how to keep them safe? Or would half of them get snatched by snakes before you finished checking the dictionary to make sure they weren’t really a dozen mongeese? Luckily these animals don’t need us to watch their backs. […]The post Mongoose Lookouts Carefully Weigh Risks (and Sing While They Do It) appeared first on Inkfish.... Read more »

  • November 19, 2014
  • 09:50 AM
  • 45 views

Video Tip of the Week: GeneFriends

by Mary in OpenHelix

It was just a little tweet, with hardly any information about the function or purpose of the resource mentioned. But the cute name drove a lot of people to take a look at GeneFriends from our blog recently, so I figured it was worth highlighting this tool as our Video Tip of the Week. So […]... Read more »

  • November 19, 2014
  • 09:25 AM
  • 51 views

A Meal More Powerful Than The NFL

by Mark Lasbury in As Many Exceptions As Rules

Tryptophan supposedly puts you to sleep at Thanksgiving, but research shows that turkey isn’t really that high in this amino acid. On the other hand, tryptophan can save lives. In several old cultures, human sacrifices increased during periods of the year when tryptophan levels in the diet were low. ... Read more »

  • November 19, 2014
  • 08:30 AM
  • 67 views

Are Dogs Good for Our Health?

by CAPB in Companion Animal Psychology Blog

We’re used to reading that they are, but it’s more complicated than you think.Photo: legenda / ShutterstockA new study by González Ramírez and Landero Hernández in Mexico compares dog-owners with non-dog-owners to find out whether or not dogs are beneficial to people’s health and well-being. They wanted to improve on the design of many previous studies by comparing two groups of people who were similar except for the fact that some owned dogs and some did not.There are several reasons w........ Read more »

  • November 19, 2014
  • 06:21 AM
  • 45 views

Why Cancer Doesn’t Favor Large Animals

by Gunnar de Winter in United Academics

Most cancers have their origin in the buildup of harmful mutations, so every active cell is at risk of unwittingly transforming into a murderer. Stands to reason then, that long-living animals with lots of cells should be more prone to succumb to the blight of cancer.... Read more »

  • November 19, 2014
  • 04:57 AM
  • 43 views

Down Syndrome Disintegrative Disorder

by Paul Whiteley in Questioning Answers

"Down syndrome disintegrative disorder seems an appropriate name for this newly recognized clinical association, which may be due to autoimmunity.""Hi, everyone. I'm Olaf and I like warm hugs!"That was the bottom line of the study published by Gordon Worley and colleagues [1] reviewing a small number of cases (N=11) of children diagnosed with Down's syndrome presenting at clinic "with a history of new-onset... or worsening... autistic characteristics" among other things. Based on some potentiall........ Read more »

  • November 19, 2014
  • 12:05 AM
  • 43 views

Are They Really up to the Task or is it Just Sandbagging?

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Among athletes with an invalid computerized neurocognitive test at baseline, 87% received valid scores upon reassessment, which suggests reassessment can be used to gain a valid baseline score.... Read more »

Schatz, P., Kelley, T., Ott, S., Solomon, G., Elbin, R., Higgins, K., & Moser, R. (2014) Utility of Repeated Assessment After Invalid Baseline Neurocognitive Test Performance. Journal of Athletic Training, 49(5), 659-664. DOI: 10.4085/1062-6050-49.3.37  

  • November 18, 2014
  • 09:29 PM
  • 51 views

Is There Such a Thing as ‘Facebook Murder’?

by Wiley Asia Blog in Wiley Asia Blog - Social Science

Investigators recently set out to consider whether homicides involving social networking sites were unique and worthy of labels such as ‘Facebook Murder’, and to explore the ways in which perpetrators had used such sites in the homicides they had committed.

The cases they identified were not collectively unique or unusual when compared with general trends and characteristics—certainly not to a degree that would necessitate the introduction of a new category of homicide or a ........ Read more »

  • November 18, 2014
  • 06:08 PM
  • 51 views

HIV-1 and autophagy: Gag, Nef, and Tat

by thelonevirologist in Virology Tidbits

Patients infected with a virus that harbours a deletion of the nef gene either do not progress to full blown AIDS or -if so- with a considerable delay compared to patients infected with “standard” HIV as well as lower virus loads, suggesting that the expression of Nef is necessary for maintaining high viral loads and AIDS pathogenicity. In addition, deletions of nef within the genome of the simian equivalent of HIV, SIV, have similar effects in Rhesus monkeys. In general, Nef is bel........ Read more »

Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, Wu L, Kominami E, Ueno T, Yamamoto A.... (2009) Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. The Journal of cell biology, 186(2), 255-68. PMID: 19635843  

Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D.... (2013) Identification of a candidate therapeutic autophagy-inducing peptide. Nature, 494(7436), 201-6. PMID: 23364696  

Geist MM, Pan X, Bender S, Bartenschlager R, Nickel W, & Fackler OT. (2014) Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef. The Journal of biological chemistry, 289(20), 14030-44. PMID: 24706755  

Dinkins, C., Pilli, M., & Kehrl, J. (2014) Roles of autophagy in HIV infection. Immunology and Cell Biology. DOI: 10.1038/icb.2014.88  

Dinkins, C., Arko-Mensah, J., & Deretic, V. (2010) Autophagy and HIV. Seminars in Cell , 21(7), 712-718. DOI: 10.1016/j.semcdb.2010.04.004  

Yang YP, Hu LF, Zheng HF, Mao CJ, Hu WD, Xiong KP, Wang F, & Liu CF. (2013) Application and interpretation of current autophagy inhibitors and activators. Acta pharmacologica Sinica, 34(5), 625-35. PMID: 23524572  

Kang R, Zeh HJ, Lotze MT, & Tang D. (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell death and differentiation, 18(4), 571-80. PMID: 21311563  

Bruno, A., De Simone, F., Iorio, V., De Marco, M., Khalili, K., Sariyer, I., Capunzo, M., Nori, S., & Rosati, A. (2014) HIV-1 Tat protein induces glial cell autophagy through enhancement of BAG3 protein levels. Cell Cycle. DOI: 10.4161/15384101.2014.952959  

Romani B, Engelbrecht S, & Glashoff RH. (2010) Functions of Tat: the versatile protein of human immunodeficiency virus type 1. The Journal of general virology, 91(Pt 1), 1-12. PMID: 19812265  

  • November 18, 2014
  • 05:14 PM
  • 68 views

Does brain training really work?

by Gabriel in Lunatic Laboratories

Ever wonder if you could be the next Einstein if only you could do some brain training? Well as it turns out, while computer based ‘brain training’ can boost memory and thinking skills in older adults, many programs promoted by the $1 billion brain training industry are ineffective.... Read more »

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