Post List

  • November 30, 1999
  • 12:00 AM
  • 3,284 views

Nicotine and the Humphrey Bogart Gene

by Dirk Hanson in Addiction Inbox

You can lead a fish to water, but can you make it smoke?

... Read more »

Petzold AM, Balciunas D, Sivasubbu S, Clark KJ, Bedell VM, Westcot SE, Myers SR, Moulder GL, Thomas MJ, & Ekker SC. (2009) Nicotine response genetics in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 106(44), 18662-7. PMID: 19858493  

  • November 30, 1999
  • 12:00 AM
  • 2,004 views

Frying Brains…

by Vatche Sahakian in Schrödinger's Dog

A review of the picture of brane world and cosmology arising from string theory.... Read more »

James M. Cline. (2007) Braneworld Cosmology. PoSstringsLHC:011,2006. arXiv: 0704.2198v1

  • November 30, 1999
  • 12:00 AM
  • 2,437 views

New GPCR Structure: Dopamine D3 Receptor

by Peter Nollert in Emerald BioStructures Blog

Yay – another GPCR structure to look at! I just noticed that the 2.9A Dopamine D3 Receptor (in complex with Eticlopride) coordinates 3PBL have been released by the PDB earlier this week. This one will take some time to digest. My congratulations go again to the Stevens lab at TSRI. This is a great achievement, well done.... Read more »

Chien, E., Liu, W., Zhao, Q., Katritch, V., Won Han, G., Hanson, M., Shi, L., Newman, A., Javitch, J., Cherezov, V.... (2010) Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science, 330(6007), 1091-1095. DOI: 10.1126/science.1197410  

  • November 30, 1999
  • 12:00 AM
  • 2,281 views

Mixture Models for Ordinal Data

by Christopher Winship in SMR Blog

Cumulative probability models are widely used for the analysis of ordinal data. In this article the authors propose cumulative probability mixture models that allow the assumptions of the cumulative probability model to hold within subsamples of the data. The subsamples are defined in terms of latent class membership. In the case of the ordered logit mixture model, on which the authors focus here, the assumption of a logistic distribution for an underlying latent dependent variable holds within ........ Read more »

Breen, R., & Luijkx, R. (2010) Mixture Models for Ordinal Data. Sociological Methods , 39(1), 3-24. DOI: 10.1177/0049124110366240  

  • November 30, 1999
  • 12:00 AM
  • 2,575 views

Cellular Feast or Famine

by Sanford- Burnham in Beaker

Not all cholesterol is bad. Every cell requires it for growth – they either have to get cholesterol somewhere or they die. A sensor called sterol regulatory element-binding protein 2 (SREBP-2) monitors cellular cholesterol levels and responds to low levels by switching on genes that allow the cell to either 1) take up more from the bloodstream or 2) manufacture more from cholesterol building blocks inside the cell. Now researchers have uncovered a third cholesterol source also controlled b........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,860 views

The neural correlates of romantic love

by DJ in Neuropoly

Examining a recent study that attempts to answer whether intense, romantic love of the kind commonly associated with young couples exists for long-term married couples as well.... ... Read more »

Acevedo BP, Aron A, Fisher HE, & Brown LL. (2011) Neural correlates of long-term intense romantic love. Social cognitive and affective neuroscience. PMID: 21208991  

DEGRECK, M., ROTTE, M., PAUS, R., MORITZ, D., THIEMANN, R., PROESCH, U., BRUER, U., MOERTH, S., TEMPELMANN, C., & BOGERTS, B. (2008) Is our self based on reward? Self-relatedness recruits neural activity in the reward system. NeuroImage, 39(4), 2066-2075. DOI: 10.1016/j.neuroimage.2007.11.006  

  • November 30, 1999
  • 12:00 AM
  • 3,437 views

Bisexuality is natural for women

by United Academics in United Academics

Researchers at the Boise State University have found that most women are bisexual by nature. Also, they discovered that these bisexual feelings increase with age. During this study, 484 heterosexual women were surveyed. 60 percent of them said to be sexually attracted to other women, 45 percent had already kissed with a woman en about half of the participants had fantasized about it.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,155 views

The Earth has one Moon, but it’s not the only rocky thing orbiting us…..

by Niall in we are all in the gutter

It's long been claimed that the Earth has more than one Moon, it doesn't. But while there is just one big rocky thing in a stable orbit around us there are also a host of smaller bodies that perform a temporary dance with the Earth.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,265 views

Red Meat Consumption May Increase Risk of Death

by United Academics in United Academics

A team of researchers from the Harvard School of Public Health in Boston have studied more than 120,000 people over 30 years to find that ‘red meat consumption is associated with an increased risk of total, CVD [Cardiovascular disease], and cancer mortality.’... Read more »

Pan, A., Sun, Q., Bernstein, A., Schulze, M., Manson, J., Stampfer, M., Willett, W., & Hu, F. (2012) Red Meat Consumption and Mortality: Results From 2 Prospective Cohort Studies. Archives of Internal Medicine. DOI: 10.1001/archinternmed.2011.2287  

  • November 30, 1999
  • 12:00 AM
  • 2,210 views

Blood Test to Predict Breast Cancer in Advance

by United Academics in United Academics

Five years from now it may be possible to prevent breast cancer by taking a simple blood test. New research shows that the chances of developing the disease are linked to a molecular modification of the gene ATM, present on white blood cells. In the future, doctors may identify women with this molecular modification to prevent breast cancer occurrence.... Read more »

Brennan, K., Garcia-Closas, M., Orr, N., Fletcher, O., Jones, M., Ashworth, A., Swerdlow, A., Thorne, H., , ., Riboli, E.... (2012) Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk. Cancer Research, 72(9), 2304-2313. DOI: 10.1158/0008-5472.CAN-11-3157  

  • November 30, 1999
  • 12:00 AM
  • 2,025 views

The Secret Feeding of Some Active Galaxies' Supermassive Black Holes--Uncovered

by Brooke N in Smaller Questions

New studies in high-energy astronomy have shown that there are many more galaxies with central supermassive black holes that are actively accreting material. In a new gamma-ray survey, about 24% of the active galaxies were not previously known to have active black hole accretion, as they did not show up in lower-energy observations.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,744 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • November 30, 1999
  • 12:00 AM
  • 2,401 views

The Aging Effects of the Sun Revealed on Trucker’s Face

by United Academics in United Academics

The man on the picture, William McElligott, spent 28 years of his life driving a delivery truck in Chicago. Only the left side of his face was exposed to the sun, with the result that it now looks much older than his right side. His case is a rare reminder of the aging effects of the sun, but also of the need to take precautions when working under certain conditions.... Read more »

Gordon, J., & Brieva, J. (2012) Unilateral Dermatoheliosis. New England Journal of Medicine, 366(16). DOI: 10.1056/NEJMicm1104059  

  • November 30, 1999
  • 12:00 AM
  • 1,371 views

New Year Resolution, Reflection on Cancer Research

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

Controversial and surprising cancer research news, point to importance of epigenetics and cell signalling research in the war on cancer.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,816 views

Tadpoles see through their asses

by Papes in Sick Papes

A compelling example of the brain’s dynamic ballsiness (i.e., the ability of neural circuits to learn to detect unfamiliar sensory stimuli), is described in a recent exercise in sickness by the duo of Blackiston and Levin. ... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,690 views

Stress Leaves Its Mark on Dad’s Sperm

by Anouk Vleugels in United Academics

For the first time, researchers have found that stress can leave an epigenetic mark on sperm, which then alters the offspring’s hypothalamic-pituitary-adrenal (HPA) axis, a part of the brain that deals with responding to stress. The study was published in the Journal of Neuroscience.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,820 views

Rats With (Not Quite) Telepathy

by Sedeer El-Showk in United Academics

Ten years ago, Professor Miguel Nicolelis and his team at Duke University made history. They implanted electrodes — sensors — into a monkey’s brain and trained her to control a robotic arm with her thoughts. That may sound like the stuff of science-fiction, but his latest work is even more incredible. In a paper recently published in Scientific Reports, Professor Nicolelis and his team used similar technology to enable a pair of rats to communicate — one brain to another ........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,348 views

2014: The Year in Science

by Viputheshwar Sitaraman in Draw Science

The year in review: innovative discoveries and progress in all different fields of science. [Infographic]... Read more »

Qiu, X., Wong, G., Audet, J., Bello, A., Fernando, L., Alimonti, J., Fausther-Bovendo, H., Wei, H., Aviles, J., Hiatt, E.... (2014) Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature, 514(7520), 47-53. DOI: 10.1038/nature13777  

Obokata, H., Wakayama, T., Sasai, Y., Kojima, K., Vacanti, M., Niwa, H., Yamato, M., & Vacanti, C. (2014) Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature, 505(7485), 641-647. DOI: 10.1038/nature12968  

Quintana, E., Barclay, T., Raymond, S., Rowe, J., Bolmont, E., Caldwell, D., Howell, S., Kane, S., Huber, D., Crepp, J.... (2014) An Earth-Sized Planet in the Habitable Zone of a Cool Star. Science, 344(6181), 277-280. DOI: 10.1126/science.1249403  

A.K. Geim, & K. S. Novoselov. (2010) The rise and rise of graphene. Nature Nanotechnology, 5(11), 755-755. DOI: 10.1038/nnano.2010.224  

  • November 30, 1999
  • 12:00 AM
  • 1,415 views

The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR

by Rogue Medic in Rogue Medic

This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.

Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »

Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139  

Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521  

  • November 30, 1999
  • 12:00 AM
  • 1,240 views

The PROCAMIO Trial – IV Procainamide vs IV Amiodarone for the Acute Treatment of Stable Wide Complex Tachycardia

by Rogue Medic in Rogue Medic

This is a very interesting trial that may surprise the many outspoken amiodarone advocates, but it should not surprise anyone who pays attention to research.

ALPS showed that we should stop giving amiodarone for unwitnessed shockable cardiac arrest. The lead researcher is still trying to spin amiodarone for witnessed shockable cardiac arrest, even though the results do not show improvement in the one outcome that matters – leaving the hospital with a brain that still works.[1],[2],[3]... Read more »

Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. The New England journal of medicine, 374(18), 1711-22. PMID: 27043165  

Marill KA, deSouza IS, Nishijima DK, Senecal EL, Setnik GS, Stair TO, Ruskin JN, & Ellinor PT. (2010) Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(3), 297-306. PMID: 20370763  

Marill KA, deSouza IS, Nishijima DK, Stair TO, Setnik GS, & Ruskin JN. (2006) Amiodarone is poorly effective for the acute termination of ventricular tachycardia. Annals of emergency medicine, 47(3), 217-24. PMID: 16492484  

Kułakowski P, Karczmarewicz S, Karpiński G, Soszyńska M, & Ceremuzyński L. (2000) Effects of intravenous amiodarone on ventricular refractoriness, intraventricular conduction, and ventricular tachycardia induction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2(3), 207-15. PMID: 11227590  

Bonny A, De Sisti A, Márquez MF, Megbemado R, Hidden-Lucet F, & Fontaine G. (2012) Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia. World journal of cardiology, 4(10), 296-301. PMID: 23110246  

Kowey PR. (1988) The calamity of cardioversion of conscious patients. The American journal of cardiology, 61(13), 1106-7. PMID: 3364364  

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