Post List

  • March 15, 2017
  • 08:30 AM
  • 246 views

CHL1 Hypermethylation in Breast Cancer

by Esperanza Martín Sánchez in EpiBeat

Breast cancer (BC) is the most common cancer among women and one of the leading causes of cancer-related deaths worldwide (1-3). It is a clinically heterogeneous disease, with at least 5 different subtypes (4) and quite variable prognosis, even within a subtype. In spite of early detection programmes, unfortunately 20-30% of early stage cases will eventually experience recurrence and develop distant metastasis. However, currently, there is no acceptable method for monitoring patients who are lik........ Read more »

Martín-Sánchez E, Mendaza S, Ulazia-Garmendia A, Monreal-Santesteban I, Blanco-Luquin I, Córdoba A, Vicente-García F, Pérez-Janices N, Escors D, Megías D.... (2017) CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer. Oncotarget. PMID: 28178655  

Stefansson OA, Moran S, Gomez A, Sayols S, Arribas-Jorba C, Sandoval J, Hilmarsdottir H, Olafsdottir E, Tryggvadottir L, Jonasson JG.... (2015) A DNA methylation-based definition of biologically distinct breast cancer subtypes. Molecular oncology, 9(3), 555-68. PMID: 25468711  

He LH, Ma Q, Shi YH, Ge J, Zhao HM, Li SF, & Tong ZS. (2013) CHL1 is involved in human breast tumorigenesis and progression. Biochemical and biophysical research communications, 438(2), 433-8. PMID: 23906755  

Smith RA, Andrews K, Brooks D, DeSantis CE, Fedewa SA, Lortet-Tieulent J, Manassaram-Baptiste D, Brawley OW, & Wender RC. (2016) Cancer screening in the United States, 2016: A review of current American Cancer Society guidelines and current issues in cancer screening. CA: a cancer journal for clinicians, 66(2), 96-114. PMID: 26797525  

Feng W, Shen L, Wen S, Rosen DG, Jelinek J, Hu X, Huan S, Huang M, Liu J, Sahin AA.... (2007) Correlation between CpG methylation profiles and hormone receptor status in breast cancers. Breast cancer research : BCR, 9(4). PMID: 17764565  

Karsli-Ceppioglu S, Dagdemir A, Judes G, Ngollo M, Penault-Llorca F, Pajon A, Bignon YJ, & Bernard-Gallon D. (2014) Epigenetic mechanisms of breast cancer: an update of the current knowledge. Epigenomics, 6(6), 651-64. PMID: 25531258  

Widschwendter M, Siegmund KD, Müller HM, Fiegl H, Marth C, Müller-Holzner E, Jones PA, & Laird PW. (2004) Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer research, 64(11), 3807-13. PMID: 15172987  

Senchenko VN, Krasnov GS, Dmitriev AA, Kudryavtseva AV, Anedchenko EA, Braga EA, Pronina IV, Kondratieva TT, Ivanov SV, Zabarovsky ER.... (2011) Differential expression of CHL1 gene during development of major human cancers. PloS one, 6(3). PMID: 21408220  

  • March 15, 2017
  • 04:30 AM
  • 219 views

Balance Assessments Unable to Predict ACL Injury in Elite Female Athletes

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Balance assessments were not associated with anterior cruciate ligament injury risk among elite female handball and soccer athletes.
... Read more »

  • March 15, 2017
  • 04:08 AM
  • 260 views

The extra-intestinal effects of coeliac disease autoimmunity?

by Paul Whiteley in Questioning Answers

"In 3.5-year-old children, CDA [coeliac disease autoimmunity] is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child’s CDA status."So said the findings reported by Laura Smith and colleagues [1] (open-access available here) adding to an emerging body of peer-reviewed research suggesting that the archetypal 'gluten is the baddie' autoimmune condition known as coeliac disease might, when not manag........ Read more »

Smith LB, Lynch KF, Kurppa K, Koletzko S, Krischer J, Liu E, Johnson SB, Agardh D, & TEDDY study group. (2017) Psychological Manifestations of Celiac Disease Autoimmunity in Young Children. Pediatrics. PMID: 28219962  

  • March 14, 2017
  • 08:26 PM
  • 236 views

‘I’m not listening to you!’ Interacting in a linguistically diverse society

by Ingrid Piller in Language on the Move

On December 23, 2016, as most Australians were winding down for the holiday week ahead, Faysal Ishak Ahmed, a 27-year-old...... Read more »

Kenison TC, Madu A, Krupat E, Ticona L, Vargas IM, & Green AR. (2017) Through the Veil of Language: Exploring the Hidden Curriculum for the Care of Patients With Limited English Proficiency. Academic medicine : journal of the Association of American Medical Colleges, 92(1), 92-100. PMID: 27166864  

  • March 14, 2017
  • 01:30 PM
  • 229 views

Internationalization as an indicator of journal performance in Brazil: the case of Psychology

by SciELO in SciELO in Perspective

The path to strengthening scientific publications almost always goes through internationalization. Publishing in English, however, is not enough to reach a truly global audience and indices comparable to the most prestigious journals. A study on the degree of internationalization of Brazilian psychology journals shows how to walk this path. … Read More →... Read more »

Gamba, E., Packer, A., & Meneghini, R. (2015) Pathways to Internationalize Brazilian Journals of Psychology. Psicologia: Reflexão e Crítica, 66-71. DOI: 10.1590/1678-7153.20152840010  

  • March 14, 2017
  • 08:05 AM
  • 237 views

Solar Science with the Atacama Large Millimeter/Submillimeter Array — A New View of Our Sun by S. Wedemeyer

by CESRA in Solar Radio Science

The Atacama Large Millimeter/submillimeter Array (ALMA), which consists of 66 antennas placed on the Chajnantor plateau in the Chilean Andes, has already produced impressive results for a large range of astronomical objects. Regular observations of the Sun have been carried out for the first time in December 2016 and exciting results can be expected soon. ALMA combines high spatial, temporal, and spectral resolution with the diagnostic advantages of radiation at [...]... Read more »

Wedemeyer, S., Bastian, T., Brajša, R., Hudson, H., Fleishman, G., Loukitcheva, M., Fleck, B., Kontar, E., De Pontieu, B., Yagoubov, P.... (2015) Solar Science with the Atacama Large Millimeter/Submillimeter Array—A New View of Our Sun. Space Science Reviews, 200(1-4), 1-73. DOI: 10.1007/s11214-015-0229-9  

  • March 14, 2017
  • 07:08 AM
  • 47 views

Nonlinear effects in shallow water waves

by Mirjam Sophia Glessmer in Adventures in Oceanography and Teaching

I recently googled for something related to the shape of waves and came across a photo of a wave that caught my eye, and it took me to a journey that lead to the article “nonlinear shallow ocean wave soliton interactions on flat beaches” by Ablowitz and Baldwin (2012). What’s discussed in that article is that while…... Read more »

Mark J. Ablowitz, & Douglas E. Baldwin. (2012) Nonlinear shallow ocean wave soliton interactions on flat beaches. Physical Review E, vol. 86(3), pp. 036305 (2012). arXiv: 1208.2904v1

  • March 14, 2017
  • 03:56 AM
  • 272 views

Depression in parents of children with autism

by Paul Whiteley in Questioning Answers

"Mothers (OR 2.95, 95% CI 2.81-3.09) and fathers (OR 2.41, 95% CI 2.25-2.58) of children with ASD [autism spectrum disorder] were more likely to have a diagnosis of depression than parents of children without ASD."The paper by Cohrs and Leslie [1] is probably not going to win any awards for novelty when it comes to their findings that: "Autism Spectrum Disorder (ASD) in children can have secondary effects on the child's parents." It does however represent another important piece of evidence........ Read more »

  • March 13, 2017
  • 11:38 AM
  • 230 views

Earliest Brain Changes in Alzheimer's Disease

by William Yates, M.D. in Brain Posts

Amyloid brain plaques are well-known pathological changes associated with Alzheimer's disease. Changes preceding amyloid plaque build up are less well studied and understood. Some of this relates to limitations to current imaging technology.Klementieva and colleagues from Sweden and Spain recently published an important reserach topic in this area.Their studied used a rat model of Alzheimer's disease and imaging techniques that included infrared microspectroscopy and gel electrophoresis.The........ Read more »

Klementieva, O., Willén, K., Martinsson, I., Israelsson, B., Engdahl, A., Cladera, J., Uvdal, P., & Gouras, G. (2017) Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP. Nature Communications, 14726. DOI: 10.1038/ncomms14726  

  • March 13, 2017
  • 07:02 AM
  • 199 views

Identifying deception when the witness wears a face-covering veil

by Rita Handrich in The Jury Room

In 2014, we wrote about research investigating how people felt when a witness wore a veil such as some forms of a hijab or a niqab. Here were some of the findings we described in that research. We’ve written a number of times about bias against Muslims. But here’s a nice article with an easy […]... Read more »

Leach AM, Ammar N, England DN, Remigio LM, Kleinberg B, & Verschuere BJ. (2016) Less is more? Detecting lies in veiled witnesses. Law and Human Behavior, 40(4), 401-10. PMID: 27348716  

  • March 13, 2017
  • 03:29 AM
  • 276 views

Mitochondria support for mitochondrial activity in [some] autism

by Paul Whiteley in Questioning Answers

"This study examined the effect of common mitochondrial treatments on specific mitochondrial components in a group of children diagnosed with ASD [autism spectrum disorder], some of which also were diagnosed with co-morbid mitochondrial disease."That was the premise of the study results published by Leanna Delhey and colleagues [1] (open-access available here) and follows previous discussions suggesting that mitochondrial disease might not be totally unfamiliar to at least some autism ........ Read more »

Delhey LM, Nur Kilinc E, Yin L, Slattery JC, Tippett ML, Rose S, Bennuri SC, Kahler SG, Damle S, Legido A.... (2017) The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder. Journal of clinical medicine, 6(2). PMID: 28208802  

  • March 11, 2017
  • 04:45 PM
  • 232 views

Badass females are unpopular among praying mantids

by Piter Boll in Earthling Nature

by Piter Kehoma Boll One of the most iconic representations of praying mantids is that of a female eating the male after (or during) sex, an unpleasant scenario that starts with a beheading before the poor male even finishes his … Continue reading →... Read more »

  • March 11, 2017
  • 04:19 AM
  • 275 views

B vitamins for schizophrenia?

by Paul Whiteley in Questioning Answers

I'd like to briefly draw your attention to the results - systematic review and meta-analysis results - published by Joseph Firth and colleagues [1] observing that "certain vitamin and mineral supplements may reduce psychiatric symptoms in some people with schizophrenia" and specifically that certain B vitamins might be something to consider.Such results come from a research team who are making significant waves in the field of meta-analyses and systematic reviews for all manner of different [imp........ Read more »

  • March 10, 2017
  • 07:02 AM
  • 173 views

Facts [still] don’t matter: the 2017 edition 

by Doug Keene in The Jury Room

When we began this blog in 2009, the reality that facts don’t matter was one of the first posts we wrote. We wrote again about this reality back in 2011. And we’ve written about it several times since then so…here we go again! In this new era of fake news and fake news allegations, we’ve […]... Read more »

Swire, B., Berinsky, A., Lewandowsky, S., & Ecker, U. (2017) Processing political misinformation: comprehending the Trump phenomenon. Royal Society Open Science, 4(3), 160802. DOI: 10.1098/rsos.160802  

  • March 10, 2017
  • 06:05 AM
  • 225 views

Spontaneous Pneumothorax and air travel in BHD Syndrome

by Joana Guedes in BHD Research Blog

Previous studies show that BHD syndrome causes spontaneous pneumothorax (SP) in 24-38% of patients, with a recurrence rate of up to 75% (Toro et al., 2007; Toro et al., 2008; Houweling et al., 2011). A common preventative strategy used following an initial SP in patients with BHD is pleurodesis, however, its efficacy in preventing recurrent episodes is not well known. Due to the pressure changes during air travel, cystic air spaces expand and compress in the thorax possibly leading to cyst ruptu........ Read more »

Gupta N, Kopras EJ, Henske EP, James LE, El-Chemaly S, Veeraraghavan S, Drake MG, & McCormack FX. (2017) Spontaneous Pneumothoraces in Patients with Birt-Hogg-Dubé Syndrome. Annals of the American Thoracic Society. PMID: 28248571  

  • March 10, 2017
  • 05:00 AM
  • 214 views

Running Shoes and the Preferred Motion Pathway

by Craig Payne in Running Research Junkie

Running Shoes and the Preferred Motion Pathway... Read more »

Nigg BM, Vienneau J, Smith AC, Trudeau MB, Mohr M, & Nigg SR. (2017) The Preferred Movement Path Paradigm: Influence of Running Shoes on Joint Movement. Medicine and science in sports and exercise. PMID: 28277405  

  • March 10, 2017
  • 02:37 AM
  • 243 views

I would walk 500 miles... or maybe just 8 miles (a day).

by Paul Whiteley in Questioning Answers

"Desk-bound workers should ‘walk EIGHT miles a day’ to slash risk of heart attacks or stroke" went one headline talking about the findings reported by William Tigbe and colleagues [1]. Drawing on data from over 110 postal workers - "(55 office-workers, 5 women, and 56 walking/delivery-workers, 10 women)" - who wore "activPAL physical activity monitors for seven days", researchers observed some potentially important trends.Alongside wearing their activity monitors, participants were also asse........ Read more »

  • March 9, 2017
  • 07:18 AM
  • 204 views

Getting High Off Snakebites?

by Neuroskeptic in Neuroskeptic_Discover

In a curious case report, Indian psychiatrists Lekhansh Shukla and colleagues describe a young man who said he regularly got high by being bitten by a snake.



The 21-year old patient sought treatment for his heavy drug abuse, which included heroin and marijuna. He also reported a less conventional habit: he visited a local snake charmer, where he was bitten on the lips by a "cobra" in order to get high:
He reported that his peers and the snake charmer informed him that he would have drows... Read more »

Shukla L, Reddy SS, Kandasamy A, & Benegal V. (2017) What kills everyone, gives a high for some-Recreational Snake Envenomation. Asian journal of psychiatry, 106-108. PMID: 28262128  

  • March 9, 2017
  • 03:58 AM
  • 207 views

This Is How Vision, Not Limbs, May Have Driven Fish onto Land

by beredim in Strange Animals






In a recent study, researchers provide a new theory for the reason we walk the Earth




A new provocative study suggests it was the power of the eyes and not the limbs that first led our ancient aquatic ancestors to make the momentous leap from water to land. According to it, crocodile-like animals first saw easy meals on land and consequently evolved limbs that enabled them to get there, ... Read more »

MacIver MA, Schmitz L, Mugan U, Murphey TD, & Mobley CD. (2017) Massive increase in visual range preceded the origin of terrestrial vertebrates. Proceedings of the National Academy of Sciences of the United States of America. PMID: 28270619  

  • March 9, 2017
  • 03:06 AM
  • 251 views

"Relatives of individuals with ASD were at higher risk of ADHD"

by Paul Whiteley in Questioning Answers

"Individuals with ASD [autism spectrum disorder] and their relatives are at increased risk of ADHD [attention-deficit hyperactivity disorder]."So said the paper published by Laura Ghirardi and colleagues [1] (open-access) who studied "1 899 654 individuals born in Sweden between 1987 and 2006" and identified some 28,000 cases of ASD and 82,000 cases of ADHD "with 13 793 individuals... being comorbid cases."Results: "Individuals with ASD were at higher risk of having ADHD, co........ Read more »

Ghirardi L, Brikell I, Kuja-Halkola R, Freitag CM, Franke B, Asherson P, Lichtenstein P, & Larsson H. (2017) The familial co-aggregation of ASD and ADHD: a register-based cohort study. Molecular psychiatry. PMID: 28242872  

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