MedicalResearch.com Interview with: Lei Xu, MD, PhD Steele Laboratory of Tumor Biology Radiation Oncology Department Massachusetts General Hospital Medical Research: What is the background for this study? Dr. Lei Xu: Neurofibromatosis 2 is characterized by benign tumors that develop throughout … Continue reading →
The post Anti-VEGF Treatment Plus Radiation For Schwannoma Control appeared first on MedicalResearch.com.
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Lei Xu, MD, PhD. (2015) Anti-VEGF Treatment Plus Radiation For Schwannoma Control. MedicalResearch.com. info:/
Our memory abilities begin to diminish in some respects as early as our twenties. But the picture isn't entirely bleak. A new study published in Psychology and Aging explores the possibility that an older person's curiosity or interest in a subject can reinforce their powers of memory. Following this view, old age is associated with forgetting more of what you don't care about, but the ability to remember what matters to you is preserved or even enhanced.Shannon McGillivray and her colleagues te........ Read more »
McGillivray, S., Murayama, K., & Castel, A. (2015) Thirst for Knowledge: The Effects of Curiosity and Interest on Memory in Younger and Older Adults. Psychology and Aging. DOI: 10.1037/a0039801
Accepting the notions that (i) correlation is not necessarily the same as causation and that (ii) case-control observational studies in particular are not the best way to ascertain whether A causes B, I was rather interested in the findings reported by Ido Lurie and colleagues  and that: "Recurrent antibiotic exposure is associated with increased risk for depression and anxiety but not for psychosis."Starting from the idea that: "Changes in the microbiota (dysbiosis) were sugge........ Read more »
Lurie, I., Yang, Y., Haynes, K., Mamtani, R., & Boursi, B. (2015) Antibiotic Exposure and the Risk for Depression, Anxiety, or Psychosis. The Journal of Clinical Psychiatry. DOI: 10.4088/JCP.15m09961
A group at the Pasteur Institute succeeded in generating a bioluminescent strain of Leptospira interrogans. Their study was published last year in PLOS Neglected Tropical Diseases.The benefit of having a bioluminescent strain is that infections of small laboratory rodents can be monitored without sacrificing the animals. Instead, the animals are placed in a special whole-body imager that detects light emitted from the bodies. The location of the infection in the animals can be ........ Read more »
Ratet G, Veyrier FJ, Fanton d'Andon M, Kammerscheit X, Nicola MA, Picardeau M, Boneca IG, & Werts C. (2014) Live imaging of bioluminescent Leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics. PLoS Neglected Tropical Diseases, 8(12). PMID: 25474719
Goris MG, Kikken V, Straetemans M, Alba S, Goeijenbier M, van Gorp EC, Boer KR, Wagenaar JF, & Hartskeerl RA. (2013) Towards the burden of human leptospirosis: duration of acute illness and occurrence of post-leptospirosis symptoms of patients in the Netherlands. PloS One, 8(10). PMID: 24098528
Fanton d'Andon M, Quellard N, Fernandez B, Ratet G, Lacroix-Lamandé S, Vandewalle A, Boneca IG, Goujon JM, & Werts C. (2014) Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways. PLoS Neglected Tropical Diseases, 8(1). PMID: 24498450
MedicalResearch.com Interview with: Charuhas Thakar, MD Director, Division of Nephrology and Hypertension Professor of Medicine University of Cincinnati Medical Research: What is the background for this study? What are the main findings? “Diabetes is the major contributor to the growing burden of end-stage renal disease,” says Charuhas Thakar, MD, professor and director of the Division of Nephrology and Hypertension at the UC College of Medicine. “Acu........ Read more »
Charuhas Thakar, MD. (2015) An Episode of Acute Kidney Injury Increases Risk and Rate of End Stage Renal Failure. MedicalResearch.com. info:/
Researchers at Case Western Reserve University and the University of Michigan have produced the first image of an important human protein as it binds with ribonucleic acid (RNA), a discovery that could offer clues to how some viruses, including HIV, control expression of their genetic material. That information could lead to new strategies to block viruses from replicating, thereby limiting or halting infection.... Read more »
Morgan, C., Meagher, J., Levengood, J., Delproposto, J., Rollins, C., Stuckey, J., & Tolbert, B. (2015) The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein. Journal of Molecular Biology, 427(20), 3241-3257. DOI: 10.1016/j.jmb.2015.05.009
Patent for Bozepinib approved by scientists of University of Granada
Researchers at the University of Granada, Spain, have patented Bozepinib, a drug that inhibits the growth of cancer stem cells in breast, colon and melanoma cancers.
The mechanisms of action of Bozepinib were first described in an article published in the Open Access journal Oncotarget back in 2014. The team showed that Bozepinib was able to inhibit growth and metastasis of tumors in mice without inducing toxicity. Follow........ Read more »
Ramírez A, Boulaiz H, Morata-Tarifa C, Perán M, Jiménez G, Picon-Ruiz M, Agil A, Cruz-López O, Conejo-García A, Campos JM.... (2014) HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. Oncotarget, 5(11), 3590-606. PMID: 24946763
A recent study indicates that Antarctic sea ice is growing, but what about its long-term evolution? Read on to see what scientists have discovered about the Antarctic's future.... Read more »
Zwally JH et al. (2015) Mass gains of the Antarctic ice sheet exceed losses. Journal of Glaciology. DOI: 10.3189/2015JoG15J071
We all have our standards. For humans, it's the five-second rule. For macaques, it's "think twice before eating food off a pile of poop." The monkeys have several ways of keeping their food (sort of) clean. And the most fastidious macaques, it seems, are rewarded with fewer parasites.
On the Japanese island of Koshima, scientists have been studying Japanese macaques (Macaca fuscata) for nearly seven decades. The tiny, forested island is overrun with the monkeys, which live there naturally... Read more »
Sarabian C, & MacIntosh AJ. (2015) Hygienic tendencies correlate with low geohelminth infection in free-ranging macaques. Biology letters, 11(11). PMID: 26538539
In the run up to the 2012 US election, President Obama visited the undecided swing-states he needed to win in order to hold on to the Presidency. A new study published in the Journal of Language and Social Psychology features an analysis of the speeches he gave, together with those of his opponent Mitt Romney, and finds it’s possible to estimate the candidates’ subsequent electoral success by measuring how audiences reacted to their speeches. It also describes how speeches are intentionally ........ Read more »
Bull, P., & Miskinis, K. (2014) Whipping It Up! An Analysis of Audience Responses to Political Rhetoric in Speeches From the 2012 American Presidential Elections. Journal of Language and Social Psychology, 34(5), 521-538. DOI: 10.1177/0261927X14564466
This week’s video tip is longer than usual. But if you want to dig deeper into all the data that you know is coming in to the UCSC Genome Browser, you want to use the Table Browser. If you’ve only used the genome browser interface, you are missing a lot of opportunity to mine for […]... Read more »
Rosenbloom, K., Armstrong, J., Barber, G., Casper, J., Clawson, H., Diekhans, M., Dreszer, T., Fujita, P., Guruvadoo, L., Haeussler, M.... (2014) The UCSC Genome Browser database: 2015 update. Nucleic Acids Research, 43(D1). DOI: 10.1093/nar/gku1177
Mangan ME, Williams JM, Kuhn RM, & Lathe WC. (2014) The UCSC Genome Browser: What Every Molecular Biologist Should Know. Current Protocols in Molecular Biology., 107(19.9), 199-199. DOI: 10.1002/0471142727.mb1909s107
As you grab your rake or leaf-blower this fall, you might wonder how it is possible for trees to make so many leaves. Learn where they all came from.... Read more »
Pijpers, J., Winkler, M., Surendranath, Y., Buonassisi, T., & Nocera, D. (2011) Light-induced water oxidation at silicon electrodes functionalized with a cobalt oxygen-evolving catalyst. Proceedings of the National Academy of Sciences, 108(25), 10056-10061. DOI: 10.1073/pnas.1106545108
E. fishelsoni s a bacterium that breaks the rules. It grows from 10 µm long to a fully visible 0.7 mm….in twelve hours! Normally, diffusion isn’t adequate for a bacterium this big because it takes too long for two interacting proteins to find one another. But what if the bacterium make more of the protein, so much more that it can find a partner all the time. How can you make that much of each protein? E. fishelsoni does it by making 85,000 copies of its genome….. ever........ Read more »
Bresler V, Montgomery WL, Fishelson L, Pollak PE. (1998) Gigantism in a bacterium, Epulopiscium fishelsoni, correlates with complex patterns in arrangement, quantity, and segregation of DNA. J Bacteriol., 180(21), 5061-5611. info:/9791108
MedicalResearch.com Interview with: Dr. Giuseppe Andò University of Messina, Messina, Italy Medical Research: What is the background for this study? Dr. Andò: Patients’ preference for radial access for coronary angiography and percutaneous intervention is paralleled by an almost complete abolition … Continue reading →
The post Radial Access For Coronary Angiography Can Reduce Bleeding and Mortality appeared first on MedicalResearch.com.
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Dr. Giuseppe Andò. (2015) Radial Access For Coronary Angiography Can Reduce Bleeding and Mortality . MedicalResearch.com. info:/
MedicalResearch.com Interview with: Dr Will Herrington MD, MRCP and Dr Natalie Staplin PhD Nuffield Department of Population Health, University of Oxford Oxford, UK Medical Research: What is the background for this study? What are the main findings? Response: These analyses … Continue reading →
The post Study Examines Higher Systolic Blood Pressure and Kidney Disease Progression appeared first on MedicalResearch.com.
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Dr Will Herrington MD, MRCP and, & Dr Natalie Staplin PhD. (2015) Study Examines Higher Systolic Blood Pressure and Kidney Disease Progression. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Dr. Wanpen Vongpatanasin MD Program Director, Hypertension Fellowship Program Professor of Internal Medicine Director of the University of Texas Southwestern Hypertension Program Medical Research: What is the background for this study? What are the main findings? Dr. Vongpatanasin: … Continue reading →
The post White Coat Hypertension Is Not Benign and Should Not Be Ignored appeared first on MedicalResearch.com.
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Dr. Wanpen Vongpatanasin MD. (2015) White Coat Hypertension Is Not Benign and Should Not Be Ignored. MedicalResearch.com. info:/
Apparently yes, at least according to today’s researchers. And you likely will be somewhat taken aback by just which group you choose to make wait. Researchers wanted to study whether the pedestrian’s race had anything to do with yielding behavior of motorists at crosswalks. They tested with 173 motorists and 6 trained male pedestrian-confederates (3 […]
Do Whites, Blacks, and Asians have different biases than Biracial adults?
Are you a White American? How Black is y........ Read more »
Goddard, T., Kahn, K., & Adkins, A. (2015) Racial bias in driver yielding behavior at crosswalks. Transportation Research Part F: Traffic Psychology and Behaviour, 1-6. DOI: 10.1016/j.trf.2015.06.002
Eager to travel to Mars? Think twice!
NASA, galactic cosmic rays, mars, space travel
Explorations of Mars with probes and spacecraft are revealing intriguing features of the Red Planet. The most recent discovery by the NASA spacecraft Mars Reconnaissance Orbiter, that liquid water very likely flows on Mars, has stirred enthusiasm among scientists who have been looking for signs of “life-as-we-know-it” on the planet for the last twenty years.
One of the major future goals of ........ Read more »
"Immune clue to preventing schizophrenia" went the BBC headline, as the paper by Peter Bloomfield and colleagues  garnered some significant media interest recently specifically tied into their findings suggesting that: "neuroinflammation is linked to the risk of psychosis and related disorders, as well as the expression of subclinical symptoms."Based on the use of "second-generation radioligand [11C]PBR28 and PET to image microglial activity in the brains of participants at ultra high risk fo........ Read more »
Bloomfield, P., Selvaraj, S., Veronese, M., Rizzo, G., Bertoldo, A., Owen, D., Bloomfield, M., Bonoldi, I., Kalk, N., Turkheimer, F.... (2015) Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [ C]PBR28 PET Brain Imaging Study . American Journal of Psychiatry. DOI: 10.1176/appi.ajp.2015.14101358
Credit: Image courtesy of Aalto UniversityIs it possible to be “addicted” to food, much like an addiction to substances (e.g., alcohol, cocaine, opiates) or behaviors (gambling, shopping, Facebook)? An extensive and growing literature uses this terminology in the context of the “obesity epidemic”, and looks for the root genetic and neurobiological causes (Carlier et al., 2015; Volkow & Bailer, 2015).Fig. 1 (Meule, 2015). Number of scientific publications on food addiction (1990-2014........ Read more »
Castro, D., & Berridge, K. (2014) Advances in the neurobiological bases for food ‘liking’ versus ‘wanting’. Physiology , 22-30. DOI: 10.1016/j.physbeh.2014.05.022
Karlsson, H., Tuulari, J., Tuominen, L., Hirvonen, J., Honka, H., Parkkola, R., Helin, S., Salminen, P., Nuutila, P., & Nummenmaa, L. (2015) Weight loss after bariatric surgery normalizes brain opioid receptors in morbid obesity. Molecular Psychiatry. DOI: 10.1038/mp.2015.153
Meule A. (2015) Back by Popular Demand: A Narrative Review on the History of Food Addiction Research. The Yale journal of biology and medicine, 88(3), 295-302. PMID: 26339213
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