Post List

  • April 3, 2014
  • 04:20 AM
  • 84 views

New life for naltrexone and autism?

by Paul Whiteley in Questioning Answers

During the very earliest days of the life of this blog I posted about the opiate antagonist naltrexone (ReVia®) and some research on its history with autism in mind; in particular, the various emerging speculations on low dose naltrexone (LDN) (see here). Today I'm following up that entry based on the results of a systematic review by Ashok Roy and colleagues [1] on the value (or not) of naltrexone for "attenuating the core symptoms of autism spectrum conditions in children"."Yadwigha........ Read more »

  • April 2, 2014
  • 05:52 PM
  • 77 views

MERS-CoV and SARS-CoV: two members of a divergent family

by thelonevirologist in Virology Tidbits

Coronavirus infections are commonly associated with relative benign respiratory and enteric diseases in humans, such as the common cold, and with outbreaks among agricultural livestock -chickens, swine or cattle. The outbreak of a novel disease in humans, severe acute respiratory syndrome (SARS), in 2003 however highlighted the potential lethal consequences of Coronavirus (CoV) induced disease in the human population.
... Read more »

Pyrc, K., Berkhout, B., & van der Hoek, L. (2006) The Novel Human Coronaviruses NL63 and HKU1. Journal of Virology, 81(7), 3051-3057. DOI: 10.1128/JVI.01466-06  

Golda A, Malek N, Dudek B, Zeglen S, Wojarski J, Ochman M, Kucewicz E, Zembala M, Potempa J, & Pyrc K. (2011) Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells. The Journal of general virology, 92(Pt 6), 1358-68. PMID: 21325482  

Ge XY, Li JL, Yang XL, Chmura AA, Zhu G, Epstein JH, Mazet JK, Hu B, Zhang W, Peng C.... (2013) Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 503(7477), 535-8. PMID: 24172901  

de Wilde AH, Raj VS, Oudshoorn D, Bestebroer TM, van Nieuwkoop S, Limpens RW, Posthuma CC, van der Meer Y, Bárcena M, Haagmans BL.... (2013) MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment. The Journal of general virology, 94(Pt 8), 1749-60. PMID: 23620378  

  • April 2, 2014
  • 05:33 PM
  • 97 views

Scientists Get Closer to Artificial Photosynthesis

by dailyfusion in The Daily Fusion

Scientists at the U.S. Department of Energy’s Argonne National Laboratory in collaboration with researchers from Arizona State University have found a way to imitate Photosystem II, the first protein complex in the long chain of reactions that use energy from the sun to create usable fuel. ... Read more »

Megiatto Jr, J., Méndez-Hernández, D., Tejeda-Ferrari, M., Teillout, A., Llansola-Portolés, M., Kodis, G., Poluektov, O., Rajh, T., Mujica, V., Groy, T.... (2014) A bioinspired redox relay that mimics radical interactions of the Tyr–His pairs of photosystem II. Nature Chemistry. DOI: 10.1038/nchem.1862  

  • April 2, 2014
  • 05:30 PM
  • 70 views

Nanoporous silicon a promising material for next-generation lithium-ion batteries

by Jonathan Trinastic in Goodnight Earth

Researchers describe new technique to create high-capacity silicon anode for next-generation batteries... Read more »

  • April 2, 2014
  • 04:07 PM
  • 73 views

Live 3-D X-ray video of a fly’s muscles in mid-flight

by sedeer in Inspiring Science

Flies are incredibly agile on the wing, pulling off twists and turns that outstrip anything we’ve accomplished. Their flight is …Continue reading →... Read more »

Walker, S., Schwyn, D., Mokso, R., Wicklein, M., Müller, T., Doube, M., Stampanoni, M., Krapp, H., & Taylor, G. (2014) In Vivo Time-Resolved Microtomography Reveals the Mechanics of the Blowfly Flight Motor. PLoS Biology, 12(3). DOI: 10.1371/journal.pbio.1001823  

  • April 2, 2014
  • 02:59 PM
  • 58 views

April 2, 2014

by Erin Campbell in HighMag Blog

Nuclear envelope breakdown is far prettier than my own breakdown when I realized that Girl Scout “cookie season” is over. Today’s image is from a paper that describes the importance of SUN proteins in nuclear envelope breakdown.Early in mitosis, a cell’s nuclear envelope breaks down to allow the attachment of chromosomes to the mitotic spindle. Nuclear envelope breakdown (NEBD) depends on a tearing process, during which microtubules pull the nuclear envelope towards the centrosomes. T........ Read more »

Turgay, Y., Champion, L., Balazs, C., Held, M., Toso, A., Gerlich, D., Meraldi, P., & Kutay, U. (2014) SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown. The Journal of Cell Biology, 204(7), 1099-1109. DOI: 10.1083/jcb.201310116  

  • April 2, 2014
  • 09:37 AM
  • 77 views

Video Tip of the Week: EuPathDB

by Mary in OpenHelix

I love pathogens and parasites. Really, I do. I mean–not up very close. But their astonishing range and cleverness often earns my respect. How these small organisms can wreak havoc on larger systems, inveigle the larger organisms to fly, carry, or ship them around during appropriate points in their life cycle, and to cloak themselves […]... Read more »

Aurrecoechea C., Brestelli J., Brunk B. P., Fischer S., Gajria B., Gao X., Gingle A., Grant G., Harb O. S., & Heiges M. (2009) EuPathDB: a portal to eukaryotic pathogen databases. Nucleic Acids Research, 38(Database). DOI: 10.1093/nar/gkp941  

  • April 2, 2014
  • 08:30 AM
  • 79 views

How About that Doggy at the Hair Salon?

by CAPB in Companion Animal Psychology Blog

Can we speed up the process of re-homing shelter dogs by getting the dog out of the shelter and into the community?Photo: AdamEdwards / ShutterstockEvery year, many dogs find new homes through animal rescues and shelters, but some have a long wait and many are never re-homed.  What if there was a way to free up shelter space and encourage people who would not visit the shelter to adopt? A new paper by Heather Mohan-Gibbons et al (2014) assesses the success of a scheme in which dogs were mov........ Read more »

  • April 2, 2014
  • 08:10 AM
  • 86 views

It’s Not Just Chili Peppers That Are Hot

by Mark Lasbury in As Many Exceptions As Rules

The same receptor that senses capsaicin and regulates body temperature is also involved in osmoregulation. New studies indicate that a variant of TRPV1 in the magnocellular neurosecretory cells work in osmoregulation but do not bind capsaicin or sense heat. Another study has elucidated that TRPV1 acts only in hypertonicty; it senses cell shrinkage. Swelling due to hypotonicity is sensed by TRPV4. Together, these form a crucial part of the osmoregulatory system.... Read more »

Holland C, van Drunen C, Denyer J, Smart K, Segboer C, Terreehorst I, Newlands A, Beerahee M, Fokkens W, & Tsitoura DC. (2013) Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist. British journal of clinical pharmacology. PMID: 23909699  

Chung G, Im ST, Kim YH, Jung SJ, Rhyu MR, & Oh SB. (2014) Activation of transient receptor potential ankyrin 1 by eugenol. Neuroscience, 153-60. PMID: 24384226  

Alpizar YA, Boonen B, Gees M, Sanchez A, Nilius B, Voets T, & Talavera K. (2014) Allyl isothiocyanate sensitizes TRPV1 to heat stimulation. Pflugers Archiv : European journal of physiology, 466(3), 507-15. PMID: 23955021  

  • April 2, 2014
  • 07:10 AM
  • 68 views

Attempts to reintroduce an endangered bird species to the Atlantic rainforest of Brazil

by Aileen Cudmore in Natural Reactions

Attempts have been made to reintroduce the endangered red-billed curassow to a wildlife reserve in Brazil... Read more »

Bernardo C. S. S., & Locke N. (2014) Reintroduction of red-billed curassow Crax blumenbachii to Guapiaçu Ecological Reserve, Brazil. Conservation Evidence, 7-7. info:/

  • April 2, 2014
  • 07:02 AM
  • 71 views

Women as Expert Witnesses: The good, the sad, and the ugly

by Rita Handrich in The Jury Room

Female attorneys know they a special challenge to being accepted as authoritative, just because they are women. Looks like things are about the same for expert witnesses who are women. A new literature review just published by Tess M.S. Neal in Behavioral Sciences and the Law offers a succinct picture of what the research has […]

Related posts:
Expert witnesses on what causes bias in other expert witnesses
We don’t need no stinkin’ plates (or expert witnesses)
What expert witnesses sh........ Read more »

  • April 2, 2014
  • 12:34 AM
  • 96 views

The Connection Between Conspiracy Theories and Ambivalence

by Eric Horowitz in peer-reviewed by my neurons

It’s a good time to be in the conspiracy theory business, and not just because the birthplace of the U.S. President has been verified only 72 times. Thanks to the internet, it’s easier than ever to track down potentially suspicious information and discuss it with like-minded gumshoes. While certain people may be predisposed to believing in certain kinds […]... Read more »

van Harreveld, F., Rutjens, B., Schneider, I., Nohlen, H., & Keskinis, K. (2014) In Doubt and Disorderly: Ambivalence Promotes Compensatory Perceptions of Order. Journal of Experimental Psychology: General. DOI: 10.1037/a0036099  

  • April 2, 2014
  • 12:29 AM
  • 81 views

OYM28: Untangling HSPs Genetic Network

by On Your Mind in On Your Mind

This week on the On Your Mind Neuroscience Podcast: It’s amazing how much a disrupted schedule can affect productivity.  This week, Liam and Kat have had their sleep patterns turned upside down for one reason or another and are dealing with the repercussions.  In Liam’s case that means working in the lab until the early ...read more
The post OYM28: Untangling HSPs Genetic Network appeared first on On Your Mind Podcast.
... Read more »

Novarino G, Fenstermaker AG, Zaki MS, Hofree M, Silhavy JL, Heiberg AD, Abdellateef M, Rosti B, Scott E, Mansour L.... (2014) Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science (New York, N.Y.), 343(6170), 506-11. PMID: 24482476  

  • April 2, 2014
  • 12:05 AM
  • 62 views

Cam Deformities Develop During Growth

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Cam deformities develop over time in skeletally immature elite soccer athletes.
... Read more »

  • April 1, 2014
  • 09:05 PM
  • 66 views

This Month In Blastocystis Research (MAR 2014)

by Christen Rune Stensvold in Blastocystis Parasite Blog

Is Blastocystis a consistent finding in Senegalese children? Novel data seem to suggest so.... Read more »

  • April 1, 2014
  • 06:17 PM
  • 81 views

Time Rolls On, Even Without Memory

by Neuroskeptic in Neuroskeptic_Discover

A fascinating paper asks what one man with no memory – and no regrets – can really teach us about time: Individuals With Episodic Amnesia Are Not Stuck In Time. Researchers Car Craver and colleagues describe the case of “KC”, a former “roadie for rock bands, prone to drinking and occasional rash behavior” who suffered […]The post Time Rolls On, Even Without Memory appeared first on Neuroskeptic.... Read more »

Craver CF, Kwan D, Steindam C, & Rosenbaum RS. (2014) Individuals With Episodic Amnesia Are Not Stuck In Time. Neuropsychologia. PMID: 24680757  

  • April 1, 2014
  • 04:24 PM
  • 81 views

Hybrid Cars More Fuel-Efficient in China, India Than in U.S.

by dailyfusion in The Daily Fusion

What makes cities in India and China so frustrating to drive in—heavy traffic, aggressive driving style, few freeways—makes them ideal for saving fuel with hybrid vehicles, according to new research by scientists at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab).... Read more »

  • April 1, 2014
  • 04:01 PM
  • 96 views

Exercise and chronic pain

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

While the overall premise of exercise is clear, the details of how often, what kind and the best approach for recovery after exercising are rather less. The problem for people with chronic pain is that moving HURTS. Some people have even argued that chronic pain is, in essence, an activity intolerance disorder... Read more »

  • April 1, 2014
  • 01:18 PM
  • 66 views

Perovskite Solar Cell Doubles as Laser

by dailyfusion in The Daily Fusion

Researchers from Professor Sir Richard Friend’s group at Cambridge’s Cavendish Laboratory—working with Snaith’s Oxford group—have demonstrated that perovskite cells can also be used to produce cheap lasers.... Read more »

Deschler, F., Price, M., Pathak, S., Klintberg, L., Jarausch, D., Higler, R., Huettner, S., Leijtens, T., Stranks, S., Snaith, H.... (2014) High Photoluminescence Efficiency and Optically-Pumped Lasing in Solution-Processed Mixed Halide Perovskite Semiconductors. The Journal of Physical Chemistry Letters, 2147483647. DOI: 10.1021/jz5005285  

  • April 1, 2014
  • 12:24 PM
  • 59 views

Researchers find a better way to grow motor neurons from stem cells

by beredim in Stem Cells Freak

Prof Fei Wang (left), scholar Qiuhao Qu (center)  andengineering professor Jianjun ChengResearchers reported today that they can generate human motor neurons from stem cells much more quickly and efficiently than previous methods allowed.The finding, described in Nature Communications, will aid efforts to model human motor neuron development, and to understand and treat spinal cord injuries and motor neuron diseases such as amyotrophic lateral sclerosis (ALS).The new method involves adding crit........ Read more »

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