The below article was recently rejected from the Journal of Neuroscience as a ‘Journal Club’ commentary on Davis et al., 2014, ‘Medial temporal lobe global similarity signals underlie recognition strength’. Hoping that my efforts will not go to waste, I’d like to give the piece an alternate home here. Please read, comment and share, all […]... Read more »
Davis T, Xue G, Love BC, Preston AR, & Poldrack RA. (2014) Global neural pattern similarity as a common basis for categorization and recognition memory. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(22), 7472-84. PMID: 24872552
by Shirley in Science of Eating Disorders
Should eating disorder patients be introduced to “junk food” or “hyper-palatable” foods during treatment? A few days ago, I stumbled across a blog post where Dr. Julie O’Toole, Founder and Director of the Kartini Clinic for Disordered Eating, argues against introducing “junk food” during ED treatment. The crux of the argument is that “hyperpalatable foods”—e.g., chips and Cheetos—are not real food and should never be forced or encouraged for anyone, regard........ Read more »
Spring, V.L., & Bulik, C.M. (2014) Implicit and explicit affect toward food and weight stimuli in anorexia nervosa. Eating Behaviors, 15(1), 91-4. PMID: 24411758
Steinglass, J.E., Sysko, R., Glasofer, D., Albano, A.M., Simpson, H.B., & Walsh, B.T. (2011) Rationale for the application of exposure and response prevention to the treatment of anorexia nervosa. The International Journal of Eating Disorders, 44(2), 134-41. PMID: 20127936
A study was recently released in Nature looking at genes linked to schizophrenia with the hope of helping researchers to find a whole host of brand new treatments for patients with the illness. Schizophrenia currently accounts for almost 25% of all psychiatric admissions of young people in the UK and current treatments aid in managing the symptoms, however no fundamentally new therapies have been developed since the 1950’s. The study which identified 108 gene loci that are altered in patie........ Read more »
Schizophrenia Working Group of the Psychiatric Genomics Consortium. (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511(7510), 421-7. PMID: 25056061
Maybe I’m dating myself here, but ever see the swamp thing movie, television show, or even the comic? Call me picky, after all we are talking about a human/plant hybrid, but he never needed to talk. I know, some of you are probably rolling your eyes at me given it’s a comic, movie or tv show [depending on your level of geek], but come on, this is science![…]... Read more »
G. Kim,, M. L. LeBlanc,, E. K. Wafula,, C. W. dePamphilis,, & J. H. Westwood. (2014) Genomic-scale exchange of mRNA between a parasitic plant and its hosts. Science. info:/10.1126/science.1253122
A recently published fly paper describes a new technique for uncovering cell-specific differences in protein interactions. I review this paper and discuss its relevance to human health.... Read more »
Mukherjee K, Slawson JB, Christmann BL, & Griffith LC. (2014) Neuron-specific protein interactions of Drosophila CASK-β are revealed by mass spectrometry. Frontiers in molecular neuroscience, 58. PMID: 25071438
An amusing look at 5 of the hottest science news stories this week... Read more »
Rechavi, O., Houri-Ze’evi, L., Anava, S., Goh, W., Kerk, S., Hannon, G., & Hobert, O. (2014) Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans. Cell, 158(2), 277-287. DOI: 10.1016/j.cell.2014.06.020
Yang B, Treweek JB, Kulkarni RP, Deverman BE, Chen CK, Lubeck E, Shah S, Cai L, & Gradinaru V. (2014) Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing. Cell. PMID: 25088144
Hsu, D., Huang, L., Nordgren, L., Rucker, D., & Galinsky, A. (2014) The Music of Power: Perceptual and Behavioral Consequences of Powerful Music. Social Psychological and Personality Science. DOI: 10.1177/1948550614542345
A group of scientists at the Okayama University, Tokyo Institute of Technology and Kyoto University has shown that iron oxide nanoparticles produced by bacteria in groundwater has a potential to be used as anode material for lithium-ion batteries.... Read more »
Hashimoto, H., Kobayashi, G., Sakuma, R., Fujii, T., Hayashi, N., Suzuki, T., Kanno, R., Takano, M., & Takada, J. (2014) Bacterial Nanometric Amorphous Fe-Based Oxide: A Potential Lithium-Ion Battery Anode Material. ACS Applied Materials , 6(8), 5374-5378. DOI: 10.1021/am500905y
Agronomists at Iowa State University say that miscanthus, a perennial grass used for biofuel production, would deliver even better yields than once thought in Iowa.... Read more »
Boersma, N., & Heaton, E. (2014) Propagation method affects Miscanthus×giganteus developmental morphology. Industrial Crops and Products, 59-68. DOI: 10.1016/j.indcrop.2014.01.059
Boersma, N., & Heaton, E. (2014) Does propagation method affect yield and survival? The potential of Miscanthus×giganteus in Iowa, USA. Industrial Crops and Products, 43-51. DOI: 10.1016/j.indcrop.2014.01.058
by Rita Handrich in The Jury Room
Of course you did. But you may want to take a look at this study because, maybe, it isn’t true after all. It certainly is a well-known myth if it is not true. This appears to be one of those situations where we add up what we know and then come up with a conclusion […]
When it comes to corporate fraud in America, men are almost always to blame
Is it true that older jurors are more likely to convict?
Birthers, deathers, and did you hear about Jimmy Hoffa?
... Read more »
Ross, M, Grossman, I, & Schryer, E. (2014) Contrary to psychological and popular opinion, there is no compelling evidence that older adults are disproportionately victimized by consumer fraud. . Perspectives on Psychological Science. info:/
It's become a truism that humans are "social animals". And yet, you've probably noticed - people on public transport or in waiting rooms seem to do everything they can not to interact. On the London tube there's an unwritten rule not to even look at one another. This is the paradox explored by Nicholas Epley and Juliana Schroeder in a series of nine new studies involving members of the public on trains, planes, in taxis and a waiting room.The investigation began with rail and bus commuters ........ Read more »
The paper by Golam Khandaker and colleagues  suggesting a higher risk of psychotic episodes (PEs) in early adolescence among those with a diagnosed childhood neurodevelopmental disorder (ND) makes for some interesting reading. Detailing several diagnoses as falling under the banner of neurodevelopmental disorder (autism spectrum, dyslexia, dyspraxia, dysgraphia, dysorthographia, dyscalculia), researchers concluded that: "The risk of PEs was higher in those with, compared with those witho........ Read more »
Khandaker GM, Stochl J, Zammit S, Lewis G, & Jones PB. (2014) A population-based longitudinal study of childhood neurodevelopmental disorders, IQ and subsequent risk of psychotic experiences in adolescence. Psychological medicine, 1-10. PMID: 25066026
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare kidney cancer susceptibility syndrome caused by autosomal dominant mutations in the FH gene. The three main symptoms of HLRCC are red skin papules called cutaneous piloleiomyomas; multiple early-onset uterine leiomyomas; … Continue reading →... Read more »
Menko FH, Maher ER, Schmidt LS, Middelton LA, Aittomäki K, Tomlinson I, Richard S, & Linehan WM. (2014) Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment. Familial cancer. PMID: 25012257
Analysis of tornado frequency data over the last half-century shows that tornadoes are occurring on fewer days but with greater density and severity, indicating that climate change may be changing the local dynamics at play.... Read more »
JB Elsner, SC Elsner, TH Jagger. (2014) The increasing efficiency of tornado days in the United States. Climate Dynamics. info:/
Astrocytes used to be the red-headed stepchild of the neurology world, but no more! Once considered to be just filler material, astrocytes are now known to function in the development and function of synapses, though the mechanisms are unclear. Today’s stunning image is from a paper showing how astrocytes can stabilize synapses, possibly serving as an important component of learning and memory. The synapses of neurons in the central nervous system are dynamic in response to learning and m........ Read more »
Bernardinelli, Y., Randall, J., Janett, E., Nikonenko, I., König, S., Jones, E., Flores, C., Murai, K., Bochet, C., Holtmaat, A.... (2014) Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability. Current Biology, 24(15), 1679-1688. DOI: 10.1016/j.cub.2014.06.025
We’ve got even more news for the HIV cure front. Yesterday we talked about broadly neutralizing antibodies, today we are going to be touching on that yet again,so if you […]... Read more »
Ariel Halper-Stromberg, Ching-Lan Lu, Florian Klein, Joshua A. Horwitz, Stylianos Bournazos, Lilian Nogueira, Thomas R. Eisenreich, Cassie Liu, Anna Gazumyan, Uwe Schaefer, Rebecca C. Furze, Michael S. Seaman.... (2014) Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice. Cell. info:/10.1016/j.cell.2014.07.043
Robin William’s suicide was a tragic, but all too familiar happening amongst humorists of this period. New research is showing that comedians, performers in the arts, and even people with better senses of humor are prone to more health problems as adults. Depression , cardiovascular, pulmonary and stress related problem are not uncommon in comedians, and even children and adults that have better sense of humor are susceptible to obesity and cardiovascular disease.
The irony is that t........ Read more »
C.R. Epstein, R.J. Epstein. (2013) Death in The New York Times: the price of fame is a faster flame . QJM: monthly journal of the Association of Physicians, 106(6), 517-521. info:/
Ferner RE, & Aronson JK. (2013) Laughter and MIRTH (Methodical Investigation of Risibility, Therapeutic and Harmful): narrative synthesis. BMJ (Clinical research ed.). PMID: 24336308
Bennett MP, & Lengacher C. (2009) Humor and Laughter May Influence Health IV. Humor and Immune Function. Evidence-based complementary and alternative medicine : eCAM, 6(2), 159-64. PMID: 18955287
Living organisms can survive and thrive in all kinds of rough environments. This would include the edges of space. There are bird species that can fly at almost 40,000 ft., as high as the highest clouds. New research is showing just how the bar headed goose is able to fly when the air is thin and the oxygen is scarce. But more impressive are the bacteria. They can actually live their whole lives in the air, dividing and growing nearly 25 miles (41 km) above the surface of the Earth. A study from........ Read more »
Pawar SP, Dhotre DP, Shetty SA, Chowdhury SP, Chaudhari BL, & Shouche YS. (2012) Genome sequence of Janibacter hoylei MTCC8307, isolated from the stratospheric air. Journal of bacteriology, 194(23), 6629-30. PMID: 23144385
Dillon ME, & Dudley R. (2014) Surpassing Mt. Everest: extreme flight performance of alpine bumble-bees. Biology letters, 10(2), 20130922. PMID: 24501268
Hawkes LA, Balachandran S, Batbayar N, Butler PJ, Chua B, Douglas DC, Frappell PB, Hou Y, Milsom WK, Newman SH.... (2013) The paradox of extreme high-altitude migration in bar-headed geese Anser indicus. Proceedings. Biological sciences / The Royal Society, 280(1750), 20122114. PMID: 23118436
This is the browser I’ve been waiting for. Stop what you are doing right now and look at EpiViz. I’ll wait.
I spend a lot of time looking at visualizations of various types of -omics data, from a number of different sources. I’ve never believed in the “one browser to rule them all” sort of thing–I think it’s important for groups to focus on special areas of data collection, curation, and visualizion. Although some parts can be reused and shared, of co........ Read more »
Chelaru Florin, Smith Llewellyn, Goldstein Naomi, & Bravo Héctor Corrada. (2014) Epiviz: interactive visual analytics for functional genomics data. Nature methods. PMID: 25086505
The war on HIV, that tricky little guy has avoided every thing we could throw at it in a broad sense. Sure a few people here and there get lucky, but we have yet to actually make any sort of we're going to kick your ass headway [don't worry it's the technical term for it]. That is hopefully going to change with a new scientific discovery that has enormous implications for HIV vaccine development. Researchers have uncovered novel properties of special HIV antibodies that promise to........ Read more »
Verkoczy Laurent, & Barton F. Haynes. (2014) HIV-1 Envelope gp41 Broadly Neutralizing Antibodies: Hurdles for Vaccine Development. PLoS Pathogens, 10(5). DOI: http://dx.doi.org/10.1371/journal.ppat.1004073
Regular readers of this blog had a heads up last year on the development of orexin receptor antagonists for the treatment of insomnia.I posted a review of an Italian clinical drug trial in humans with insomnia paired with polysomnography. This study used three different doses of a orexin receptor antagonist (10 mg 30 mg and 60 mg).In a second post, I reviewed a sleep lab study of the effects of an orexin antagonist drug compared to zolpidem (Ambien) on sleep architecture.This second study found ........ Read more »
Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal AD, Benca RM, Cohn M.... (2014) Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet neurology, 13(5), 461-71. PMID: 24680372
Bennett T, Bray D, & Neville MW. (2014) Suvorexant, a dual orexin receptor antagonist for the management of insomnia. P , 39(4), 264-6. PMID: 24757363
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