Post List

  • August 15, 2014
  • 04:07 AM
  • 108 views

Psychotic experience following childhood neurodevelopmental diagnosis

by Paul Whiteley in Questioning Answers

The paper by Golam Khandaker and colleagues [1] suggesting a higher risk of psychotic episodes (PEs) in early adolescence among those with a diagnosed childhood neurodevelopmental disorder (ND) makes for some interesting reading. Detailing several diagnoses as falling under the banner of neurodevelopmental disorder (autism spectrum, dyslexia, dyspraxia, dysgraphia, dysorthographia, dyscalculia), researchers concluded that: "The risk of PEs was higher in those with, compared with those witho........ Read more »

  • August 15, 2014
  • 02:00 AM
  • 20 views

Guidelines for HLRCC kidney cancer risk, surveillance and treatment published

by Lizzie Perdeaux in BHD Research Blog

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare kidney cancer susceptibility syndrome caused by autosomal dominant mutations in the FH gene. The three main symptoms of HLRCC are red skin papules called cutaneous piloleiomyomas; multiple early-onset uterine leiomyomas; … Continue reading →... Read more »

  • August 14, 2014
  • 08:27 PM
  • 128 views

Few but strong: dense tornado clusters on the rise in the United States

by Jonathan Trinastic in Goodnight Earth

Analysis of tornado frequency data over the last half-century shows that tornadoes are occurring on fewer days but with greater density and severity, indicating that climate change may be changing the local dynamics at play.... Read more »

JB Elsner, SC Elsner, TH Jagger. (2014) The increasing efficiency of tornado days in the United States. Climate Dynamics. info:/

  • August 14, 2014
  • 03:54 PM
  • 99 views

August 14, 2014

by Erin Campbell in HighMag Blog

Astrocytes used to be the red-headed stepchild of the neurology world, but no more! Once considered to be just filler material, astrocytes are now known to function in the development and function of synapses, though the mechanisms are unclear. Today’s stunning image is from a paper showing how astrocytes can stabilize synapses, possibly serving as an important component of learning and memory. The synapses of neurons in the central nervous system are dynamic in response to learning and m........ Read more »

Bernardinelli, Y., Randall, J., Janett, E., Nikonenko, I., König, S., Jones, E., Flores, C., Murai, K., Bochet, C., Holtmaat, A.... (2014) Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability. Current Biology, 24(15), 1679-1688. DOI: 10.1016/j.cub.2014.06.025  

  • August 14, 2014
  • 03:35 PM
  • 147 views

Bringing the Fight to hidden HIV

by Gabriel in Lunatic Laboratories

We’ve got even more news for the HIV cure front. Yesterday we talked about broadly neutralizing antibodies, today we are going to be touching on that yet again,so if you […]... Read more »

Ariel Halper-Stromberg, Ching-Lan Lu, Florian Klein, Joshua A. Horwitz, Stylianos Bournazos, Lilian Nogueira, Thomas R. Eisenreich, Cassie Liu, Anna Gazumyan, Uwe Schaefer, Rebecca C. Furze, Michael S. Seaman.... (2014) Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice. Cell. info:/10.1016/j.cell.2014.07.043

  • August 14, 2014
  • 02:00 PM
  • 141 views

Dying To Make Us Laugh

by Mark E. Lasbury in The 'Scope

Robin William’s suicide was a tragic, but all too familiar happening amongst humorists of this period. New research is showing that comedians, performers in the arts, and even people with better senses of humor are prone to more health problems as adults. Depression , cardiovascular, pulmonary and stress related problem are not uncommon in comedians, and even children and adults that have better sense of humor are susceptible to obesity and cardiovascular disease.

The irony is that t........ Read more »

C.R. Epstein, R.J. Epstein. (2013) Death in The New York Times: the price of fame is a faster flame . QJM: monthly journal of the Association of Physicians, 106(6), 517-521. info:/

Greengross G. (2013) Humor and aging - a mini-review. Gerontology, 59(5), 448-53. PMID: 23689078  

Bennett MP, & Lengacher C. (2009) Humor and Laughter May Influence Health IV. Humor and Immune Function. Evidence-based complementary and alternative medicine : eCAM, 6(2), 159-64. PMID: 18955287  

  • August 14, 2014
  • 01:55 PM
  • 108 views

Getting High On Life

by Mark Lasbury in As Many Exceptions As Rules

Living organisms can survive and thrive in all kinds of rough environments. This would include the edges of space. There are bird species that can fly at almost 40,000 ft., as high as the highest clouds. New research is showing just how the bar headed goose is able to fly when the air is thin and the oxygen is scarce. But more impressive are the bacteria. They can actually live their whole lives in the air, dividing and growing nearly 25 miles (41 km) above the surface of the Earth. A study from........ Read more »

Pawar SP, Dhotre DP, Shetty SA, Chowdhury SP, Chaudhari BL, & Shouche YS. (2012) Genome sequence of Janibacter hoylei MTCC8307, isolated from the stratospheric air. Journal of bacteriology, 194(23), 6629-30. PMID: 23144385  

Hawkes LA, Balachandran S, Batbayar N, Butler PJ, Chua B, Douglas DC, Frappell PB, Hou Y, Milsom WK, Newman SH.... (2013) The paradox of extreme high-altitude migration in bar-headed geese Anser indicus. Proceedings. Biological sciences / The Royal Society, 280(1750), 20122114. PMID: 23118436  

  • August 14, 2014
  • 12:20 PM
  • 94 views

Video Tip of the Week: EpiViz Genome Browsing (and more)

by Mary in OpenHelix

This is the browser I’ve been waiting for. Stop what you are doing right now and look at EpiViz. I’ll wait.

I spend a lot of time looking at visualizations of various types of -omics data, from a number of different sources. I’ve never believed in the “one browser to rule them all” sort of thing–I think it’s important for groups to focus on special areas of data collection, curation, and visualizion. Although some parts can be reused and shared, of co........ Read more »

Chelaru Florin, Smith Llewellyn, Goldstein Naomi, & Bravo Héctor Corrada. (2014) Epiviz: interactive visual analytics for functional genomics data. Nature methods. PMID: 25086505  

  • August 14, 2014
  • 12:10 PM
  • 113 views

HIV Vaccine One Step Closer to Reality

by Gabriel in Lunatic Laboratories

The war on HIV, that tricky little guy has avoided every thing we could throw at it in a broad sense. Sure a few people here and there get lucky, but we have yet to actually make any sort of we're going to kick your ass headway [don't worry it's the technical term for it]. That is hopefully going to change with a new scientific discovery that has enormous implications for HIV vaccine development. Researchers have uncovered novel properties of special HIV antibodies that promise to........ Read more »

  • August 14, 2014
  • 11:17 AM
  • 94 views

FDA Approves Novel Insomnia Drug Suvorexant (Belsomra)

by William Yates, M.D. in Brain Posts

Regular readers of this blog had a heads up last year on the development of orexin receptor antagonists for the treatment of insomnia.I posted a review of an Italian clinical drug trial in humans with insomnia paired with polysomnography. This study used three different doses of a orexin receptor antagonist (10 mg 30 mg and 60 mg).In a second post, I reviewed a sleep lab study of the effects of an orexin antagonist drug compared to zolpidem (Ambien) on sleep architecture.This second study found ........ Read more »

  • August 14, 2014
  • 09:30 AM
  • 102 views

Competition for ecological niches limits evolution of new species | @GrrlScientist

by GrrlScientist in GrrlScientist

A recently published study finds that competition for ecological niches limits the evolution of new species. Further, this study finds that speciation rate slows or even stops as available ecological niches fill up. Continue reading...... Read more »

Price Trevor D., Hooper Daniel M., Buchanan Caitlyn D., Johansson Ulf S., Tietze D. Thomas, Alström Per, Olsson Urban, Ghosh-Harihar Mousumi, Ishtiaq Farah, & Gupta Sandeep K. (2014) Niche filling slows the diversification of Himalayan songbirds. Nature. DOI: 10.1038/nature13272  

Kennedy Jonathan D., Weir Jason T., Hooper Daniel M. , Tietze D. Thomas, Martens Jochen, & Price Trevor D. (2012) Ecological limits on diversification of the Himalayan core Corvoidea. Evolution, 66(8), 2599-2613. DOI: 10.1111/j.1558-5646.2012.01618.x  

Harmon Luke J., Schulte James A., Larson Allan, & Losos Jonathan B. (2003) Tempo and Mode of Evolutionary Radiation in Iguanian Lizards. Science, 301(5635), 961-964. DOI: 10.1126/science.1084786  

  • August 14, 2014
  • 04:09 AM
  • 103 views

Learning disability in autism: how prevalent is it?

by Paul Whiteley in Questioning Answers

"Results showed that 36.8 % of the children met the criteria for ID [intellectual disability], with 60.2 % of these in the mild range (IQ 50-69) and 39.8 % in the moderate range (IQ 35-49)".That was the finding reported by Mélina Rivard and colleagues [1] looking at the co-occurrence of intellectual disability (also called learning disability here in Blighty) and autism spectrum disorder (ASD) "in young children". Based on an analysis of over 200 children diagnosed with an ASD, resear........ Read more »

  • August 13, 2014
  • 11:35 PM
  • 86 views

The Controversy of Admitting 'We Do Not Know What Works'

by Rogue Medic in Rogue Medic

There are several news articles today criticizing a study because the patients might be deprived of a drug that has not been adequately studied in humans. This criticism is coming from journalists – the people who publicized the fraudulent vaccines research by Andrew Wakefield, who was trying to sell his competing vaccine and was being paid to produce negative research by lawyers suing the vaccine companies.[1]

The real controversy is that this untested drug became the standard of care ........ Read more »

Larabee TM, Liu KY, Campbell JA, & Little CM. (2012) Vasopressors in cardiac arrest: a systematic review. Resuscitation, 83(8), 932-9. PMID: 22425731  

Herlitz J, Ekström L, Wennerblom B, Axelsson A, Bång A, & Holmberg S. (1995) Adrenaline in out-of-hospital ventricular fibrillation. Does it make any difference?. Resuscitation, 29(3), 195-201. PMID: 7667549  

Olasveengen, T., Sunde, K., Brunborg, C., Thowsen, J., Steen, P., & Wik, L. (2009) Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest: A Randomized Trial. JAMA: The Journal of the American Medical Association, 302(20), 2222-2229. DOI: 10.1001/jama.2009.1729  

Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, & Miyazaki S. (2012) Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA : the journal of the American Medical Association, 307(11), 1161-8. PMID: 22436956  

Hayashi Y, Iwami T, Kitamura T, Nishiuchi T, Kajino K, Sakai T, Nishiyama C, Nitta M, Hiraide A, & Kai T. (2012) Impact of early intravenous epinephrine administration on outcomes following out-of-hospital cardiac arrest. Circulation journal : official journal of the Japanese Circulation Society, 76(7), 1639-45. PMID: 22481099  

Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552  

Stiell IG, Hebert PC, Weitzman BN, Wells GA, Raman S, Stark RM, Higginson LA, Ahuja J, & Dickinson GE. (1992) High-dose epinephrine in adult cardiac arrest. The New England journal of medicine, 327(15), 1045-50. PMID: 1522840  

Callaway, C. (2012) Questioning the Use of Epinephrine to Treat Cardiac Arrest. JAMA: The Journal of the American Medical Association, 307(11), 1198. DOI: 10.1001/jama.2012.313  

  • August 13, 2014
  • 06:48 PM
  • 86 views

Coronavirus and Coxsackievirus B3: p62/SQSTM1and EDEM1

by thelonevirologist in Virology Tidbits

The cleavage of p62/SQSTM1 and NBR1 by the Coxsackievirus B3 proteases 2Apro and 3Cpro respectively raises the question if other viruses, in particular positive strand RNA viruses, also target p62/SQSTM1 and inhibit selective autophagy. Furthermore as outlined before the inactivation of p62/SQSTM1 raises the possibility that the subsequent ER stress may favour the formation of EDEMosomes via increased expression of EDEM1 and other components of the ERAD pathway, notably EDEM-2/-3 and OS-9, in ad........ Read more »

Cottam EM, Whelband MC, & Wileman T. (2014) Coronavirus NSP6 restricts autophagosome expansion. Autophagy, 10(8), 1426-41. PMID: 24991833  

Le Fourn V, Park S, Jang I, Gaplovska-Kysela K, Guhl B, Lee Y, Cho JW, Zuber C, & Roth J. (2013) Large protein complexes retained in the ER are dislocated by non-COPII vesicles and degraded by selective autophagy. Cellular and molecular life sciences : CMLS, 70(11), 1985-2002. PMID: 23338832  

  • August 13, 2014
  • 08:09 AM
  • 90 views

Stuck In The Middle: Migration Routes Of Hybrid Birds

by Gunnar de Winter in United Academics

Birds migrate long distances, via set routes and this behavior is partially genetic. But what’s the migration behavior then of hybrids with parents that employ two different travel routes? A new study provides fascinating answers.... Read more »

  • August 13, 2014
  • 08:00 AM
  • 110 views

Getting High On Life

by Mark Lasbury in As Many Exceptions As Rules

Living organisms can survive and thrive in all kinds of rough environments. This would include the edges of space. There are bird species that can fly at almost 40,000 ft., as high as the highest clouds. New research is showing just how the bar headed goose is able to fly when the air is thin and the oxygen is scarce. But more impressive are the bacteria. They can actually live their whole lives in the air, dividing and growing nearly 25 miles (41 km) above the surface of the Earth. A study from........ Read more »

Pawar SP, Dhotre DP, Shetty SA, Chowdhury SP, Chaudhari BL, & Shouche YS. (2012) Genome sequence of Janibacter hoylei MTCC8307, isolated from the stratospheric air. Journal of bacteriology, 194(23), 6629-30. PMID: 23144385  

Hawkes LA, Balachandran S, Batbayar N, Butler PJ, Chua B, Douglas DC, Frappell PB, Hou Y, Milsom WK, Newman SH.... (2013) The paradox of extreme high-altitude migration in bar-headed geese Anser indicus. Proceedings. Biological sciences / The Royal Society, 280(1750), 20122114. PMID: 23118436  

  • August 13, 2014
  • 07:02 AM
  • 70 views

“I see my patients as less than fully human”

by Doug Keene in The Jury Room

Here’s an intriguing article on how some nurses cope with stress. If you think, based on the title of this post, they do it by dehumanizing their patients, you would be correct. Somehow we think this is not a good thing to admit on the witness stand, but it is an understandable and human reaction […]

Related posts:
I see diversity, you see divisiveness
The new issue of The Jury Expert is available now!
When you expect a gorilla you often miss other unexpected things


... Read more »

Trifiletti, E, Di Bernardo, GA, Falvo, R, & Capozza, D. (2014) Patients are not fully human: a nurse’s coping response to stress. . Journal of Applied Social Psychology. . info:/

  • August 13, 2014
  • 04:49 AM
  • 43 views

The stability of your personality peaks in mid-life (then grows increasingly wobbly again)

by BPS Research Digest in BPS Research Digest

As we continue to settle into ourselves, you might think that personality would be something that becomes ever more cemented through life.  Not so, according to a survey of nearly 4000 New Zealanders aged from 20 to 80 years (including 2409 women). Petar Milojev and Chris Sibley report that the stability of personality increases through youth, peaks in mid-life and then gradually reduces again into old age, presumably in response to the variations in social and biological pressures we exper........ Read more »

  • August 13, 2014
  • 04:11 AM
  • 88 views

Neonatal intensive care unit (NICU) survivors and greater risk of autism?

by Paul Whiteley in Questioning Answers

"In term NICU [neonatal intensive care unit] survivors, ASD [autism spectrum disorder] occurs with a greater frequency than in the general population and often develops alongside comorbid conditions". That was the conclusion from the study by Alexander Winkler-Schwartz and colleagues [1] looking at term at-risk infants who survived NICU."You were only meant to blow the bloody doors off"'Surviving' their earliest days spent in NICU brings a bit of lump to my throat. As a paren........ Read more »

  • August 13, 2014
  • 12:05 AM
  • 69 views

Make Sure You Charge That Phone Before Measuring Anterior Tibial Translation

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

A mobile phone arthrometer application may be a reliable alternative to the KT-1000 when measuring anterior tibial translation following an anterior cruciate ligament injury.... Read more »

Andrea, F., Luigi, V., Daniele, M., Luca, M., Paolo, I., Giovanni, G., Fabio, C., & Raffaele, I. (2014) Smartphone versus knee ligament arthrometer when size does not matter. International Orthopaedics. DOI: 10.1007/s00264-014-2432-9  

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