Handling your emotions in a close relationship is often a balancing act. You want to be true to yourself and open with your partner, but there are also times when it seems necessary to exert some emotional control – to hide your frustration, for example, or to feign happiness at their news (perhaps your partner is thrilled about a work trip, which in truth you'd rather they didn't take).A new study, published recently in the Journal of Psychology, is among the first the explore the toll of the........ Read more »
Seger-Guttmann, T., & Medler-Liraz, H. (2015) The Costs of Hiding and Faking Emotions: The Case of Extraverts and Introverts. The Journal of Psychology, 1-20. DOI: 10.1080/00223980.2015.1052358
"This is the first study to show, to the best of our knowledge, that a 12-week intervention with omega-3 PUFAs [polyunsaturated fatty acids] prevented transition to full-threshold psychotic disorder and led to sustained symptomatic and functional improvements in young people with an at-risk mental state for 7 years (median)."So said the quite remarkable findings reported by Paul Amminger and colleagues  (open-access available here) who followed up their previous research study  l........ Read more »
Amminger GP, Schäfer MR, Schlögelhofer M, Klier CM, & McGorry PD. (2015) Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study. Nature communications, 7934. PMID: 26263244
The recent publication of our paper “Current methods for automated filtering of multiple sequence alignments frequently worsen single-gene phylogenetic inference” in Systematic Biology is the conclusion of 5 years of work, most of which was spent in peer-review. I will write a separate post on the issue of pre- vs. post-publication in a later post; for now, I’ll summarise our main results and try to provide an intuition for them.
Does automatic alignment filtering lead to bett........ Read more »
Tan, G., Muffato, M., Ledergerber, C., Herrero, J., Goldman, N., Gil, M., & Dessimoz, C. (2015) Current Methods for Automated Filtering of Multiple Sequence Alignments Frequently Worsen Single-Gene Phylogenetic Inference. Systematic Biology, 64(5), 778-791. DOI: 10.1093/sysbio/syv033
MedicalResearch.com Interview with: Keith A. Crandall, PhD Director – Computational Biology Institute George Washington University Innovation Hall Suite 305 Ashburn, VA 20147-2766 Medical Research: What is the background for this study? What are the main findings? Dr. Crandall: We wanted … Continue reading →
The post Microbiome Differs Between Schizophrenic Patients and Controls appeared first on MedicalResearch.com Medical Research Interviews and News.
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MedicalResearch.com Interview with:, & Keith A. Crandall, PhD. (2015) Microbiome Differs Between Schizophrenic Patients and Controls. MedicalResearch.com. info:/
Are there areas of the cerebral cortex purely devoted to vision? Or can the "visual" cortex, under some conditions, respond to sounds? Two papers published recently address this question.
First off, Micah Murray and colleagues of Switzerland discuss The multisensory function of primary visual cortex in humans in a review paper published in Neuropsychologia.
They criticize the conventional view that the primary visual cortex (in the occipital lobe) is little more than a reception point ... Read more »
Bedny M, Richardson H, & Saxe R. (2015) "Visual" Cortex Responds to Spoken Language in Blind Children. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(33), 11674-81. PMID: 26290244
Murray MM, Thelen A, Thut G, Romei V, Martuzzi R, & Matusz PJ. (2015) The multisensory function of primary visual cortex in humans. Neuropsychologia. PMID: 26275965
MedicalResearch.com Interview with: Tuya Pal MD Division of Population Sciences Department of Health Outcomes and Behavior Moffitt Cancer Center Tampa, Florida Medical Research: What is the background for this study? Dr. Pal: Young Black women bear a disproportionate burden … Continue reading →
The post Young Breast Cancer Patients Have Much Higher BRCA Mutation Than White appeared first on MedicalResearch.com Medical Research Interviews and News.
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MedicalResearch.com Interview with:, & Tuya Pal MD. (2015) Young Breast Cancer Patients Have Much Higher BRCA Mutation Than White. MedicalResearch.com. info:/
The splicing regulator PTBP1 undergoes is alternatively spliced in mammals to exclude a single exon. Here, researchers at the University of Toronto show for the first time how this uniquely evolved splice isoform functions to facilitate neural differentiation.... Read more »
Gueroussov S, Gonatopoulos-Pournatzis T, Irimia M, Raj B, Lin ZY, Gingras AC, & Blencowe BJ. (2015) RNA SPLICING. An alternative splicing event amplifies evolutionary differences between vertebrates. Science (New York, N.Y.), 349(6250), 868-73. PMID: 26293963
MedicalResearch.com Interview with: Adi V. Gundlapalli, MD, PhD Associate Professor of Internal Medicine University of Utah School of Medicine and University of Utah Hospitals and ClinicsInformatics, Decision Enhancement, and Analytic Sciences Center VA Salt Lake City Health Care System, Salt Lake City, … Continue reading →
The post Misconduct During Military Service Is Strongest Predictor of Homelessness After Discharge appeared first on MedicalResearch.com Medical Research Interv........ Read more »
Adi V. Gundlapalli, MD, PhD. (2015) Misconduct During Military Service Is Strongest Predictor of Homelessness After Discharge. MedicalResearch.com. info:/
Could the sperm harpoon the egg to facilitate fertilization? That’s the intriguing possibility raised by the University of Virginia School of Medicine’s discovery that a protein within the head of the sperm forms spiky filaments, suggesting that these tiny filaments may lash together the sperm and its target.... Read more »
Zheng, H., Mandal, A., Shumilin, I., Chordia, M., Panneerdoss, S., Herr, J., & Minor, W. (2015) Sperm Lysozyme-Like Protein 1 (SLLP1), an intra-acrosomal oolemmal-binding sperm protein, reveals filamentous organization in protein crystal form. Andrology, 3(4), 756-771. DOI: 10.1111/andr.12057
Bacteria and fungi are basically everywhere, so it's not much of a surprise to find them in food. Heck, unless they're Salmonella or have managed to multiply to the point of being visible or stinking things up, we usually don't care. Moving up a bit on the size scale, there are a couple of tiny animals inhabiting foods we eat. These include itty bitty worms living in artisanal vinegars and mites residing upon classy European cheeses.The vinegar eelworm (Turbatrix aceti) is a resilient microbe-ea........ Read more »
Melnyk J, Smith A, Scott-Dupree C, Marcone M, & Hill A. (2010) Identification of cheese mite species inoculated on Mimolette and Milbenkase cheese through cryogenic scanning electron microscopy. Journal of Dairy Science, 93(8), 3461-3468. DOI: 10.3168/jds.2009-2937
Our summer reading list is all about play.Why do animals play? In Dog Sense, John Bradshaw writes “In wild animals, play must promote survival; otherwise, evolution would select against it – a young animal that is playing out in the open is much more obvious to a predator than one sleeping in its den. However, the benefits of play do not usually become apparent until months later, when they emerge in the form of better social integration or more sophisticated hunting techniques (to name........ Read more »
Norman, K., Pellis, S., Barrett, L., & Peter Henzi, S. (2015) Down but not out: Supine postures as facilitators of play in domestic dogs. Behavioural Processes, 88-95. DOI: 10.1016/j.beproc.2014.09.001
MedicalResearch.com Interview with: Alicia A. Bergman, Ph.D. Research Health Scientist VA Greater Los Angeles Healthcare System Center for the Study of Healthcare Innovation, Implementation & Policy North Hills, CA 91343 Medical Research: What is the background for this study? What are … Continue reading →
The post Communication During Handoffs Varies Greatly Among Hospital Teams appeared first on MedicalResearch.com Medical Research Interviews and News.
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Alicia A. Bergman, Ph.D. (2015) Communication During Handoffs Varies Greatly Among Hospital Teams. MedicalResearch.com. info:/
The HMDB, or Human Metabolome DataBase, is another nice data collection and tools from the Wishart lab. Although we have mentioned it in the past, because of it’s emphasis more on small molecules it isn’t something we covered in detail. But with this new video that’s available, I thought it was a good time to […]... Read more »
Wishart, D., Jewison, T., Guo, A., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E.... (2012) HMDB 3.0--The Human Metabolome Database in 2013. Nucleic Acids Research, 41(D1). DOI: 10.1093/nar/gks1065
Xia, J., Broadhurst, D., Wilson, M., & Wishart, D. (2012) Translational biomarker discovery in clinical metabolomics: an introductory tutorial. Metabolomics, 9(2), 280-299. DOI: 10.1007/s11306-012-0482-9
MedicalResearch.com Interview with: Dr. Eric Reiman MD Executive Director, Banner Alzheimer’s Institute (BAI) Chief Executive Officer, Banner Research Clinical Director of the Neurogenomics Division at the Translational Genomics Research Institute (TGen) Professor of Psychiatry, University of Arizona Director, Arizona Alzheimer’s … Continue reading →
The post Many Patients with Clinical Alzheimer’s Do Not Have Significant Amyloid Pathology appeared first on MedicalResearch.com ........ Read more »
Dr. Eric Reiman MD. (2015) Many Patients with Clinical Alzheimer’s Do Not Have Significant Amyloid Pathology. MedicalResearch.com. info:/
Not every pair of monozygotic twins have the same chromosomes. Mosaic twins can be boy and girl, yet both babies come from a single zygote. The strange part is that the tests we run to prevent IVF problems may actually contribute to mosaic twinning. And have you heard of polar body twins? They’re ½ identical twins!... Read more »
Wei, Y., Zhang, T., Wang, Y., Schatten, H., & Sun, Q. (2014) Polar Bodies in Assisted Reproductive Technology: Current Progress and Future Perspectives. Biology of Reproduction, 92(1), 19-19. DOI: 10.1095/biolreprod.114.125575
Gardner AJ, & Evans JP. (2006) Mammalian membrane block to polyspermy: new insights into how mammalian eggs prevent fertilisation by multiple sperm. Reproduction, fertility, and development, 18(1-2), 53-61. PMID: 16478602
Souter, V., Parisi, M., Nyholt, D., Kapur, R., Henders, A., Opheim, K., Gunther, D., Mitchell, M., Glass, I., & Montgomery, G. (2006) A case of true hermaphroditism reveals an unusual mechanism of twinning. Human Genetics, 121(2), 179-185. DOI: 10.1007/s00439-006-0279-x
Taylor, D., Thum, M., & Abdalla, H. (2008) Dichorionic triamniotic triplet pregnancy with monozygotic twins discordant for trisomy 13 after preimplantation genetic screening: case report. Fertility and Sterility, 90(5), 201700000-2147483647. DOI: 10.1016/j.fertnstert.2008.01.095
Rosenbusch B, & Hancke K. (2012) Conjoined human oocytes observed during assisted reproduction: description of three cases and review of the literature. Romanian journal of morphology and embryology , 53(1), 189-92. PMID: 22395521
Tachon, G., Lefort, G., Puechberty, J., Schneider, A., Jeandel, C., Boulot, P., Prodhomme, O., Meyer, P., Taviaux, S., Touitou, I.... (2014) Discordant sex in monozygotic XXY/XX twins: a case report. Human Reproduction, 29(12), 2814-2820. DOI: 10.1093/humrep/deu275
MedicalResearch.com Interview with: Elizabeth Aura McClintock PhD Assistant Professor Department of Sociology University of Notre Dame Notre Dame, IN 46556 Medical Research: What is the background for this study? What are the main findings? Dr. McClintock: Sexual identity is a … Continue reading →
The post Sexual Identity More Fluid In Women appeared first on MedicalResearch.com Medical Research Interviews and News.
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Elizabeth Aura McClintock PhD. (2015) Sexual Identity More Fluid In Women. MedicalResearch.com. info:/
In cancer genomics, we typically identify somatic alterations by sequencing DNA from both a tumor and a matched normal “control” sample from the same patient. The Cancer Genome Atlas and other large-scale efforts to characterize tumor genomes have typically used this approach, because it allows mutation callers (like VarScan 2) to distinguish between inherited variation and acquired (somatic) […]... Read more »
Hiltemann S, Jenster G, Trapman J, van der Spek P, & Stubbs A. (2015) Discriminating somatic and germline mutations in tumor DNA samples without matching normals. Genome research. PMID: 26209359
The link between the mind and brain is tricky enough for expert psychologists and neuroscientists to grapple with, let alone young children. Nonetheless, they grow up with their own naive understanding. For example, there's some cute research from the 90s that found, somewhere between age 7 and 9, most children come to see the brain as containing thoughts and memories – they'll say that a skunk with a brain transplant from a rabbit will have memories of being a rabbit. Younger kids, by co........ Read more »
Rossi, S., Lanoë, C., Poirel, N., Pineau, A., Houdé, O., & Lubin, A. (2015) When I Met my brain: Participating in a neuroimaging study influences children’s naïve mind–brain conceptions. Trends in Neuroscience and Education. DOI: 10.1016/j.tine.2015.07.001
I briefly want to bring the paper from Lucia Billeci and colleagues  to your attention today and the suggestion that following their systematic review of the current peer-reviewed literature, there seemed to be something of "an association between ASD [autism spectrum disorder] and AD [atopic dermatitis]."Atopic, by the way, refers to sensitivity to allergens, and in the case of AD, how such sensitivity manifests on the skin causing itchiness, redness and the skin to ........ Read more »
Billeci L, Tonacci A, Tartarisco G, Ruta L, Pioggia G, & Gangemi S. (2015) Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review. American journal of clinical dermatology. PMID: 26254000
Take Home Message: A systematic review of 11 studies revealed that patients who either received anterior cruciate ligament (ACL) reconstruction or remained deficient (ACL-D) reported lower quality of life than the general healthy population.... Read more »
Filbay, S., Culvenor, A., Ackerman, I., Russell, T., & Crossley, K. (2015) Quality of life in anterior cruciate ligament-deficient individuals: a systematic review and meta-analysis. British Journal of Sports Medicine, 49(16), 1033-1041. DOI: 10.1136/bjsports-2015-094864
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