I must thank Leah Hardy (@LeahFHardy) for bringing to my attention the paper by Qinglong Shang and colleagues  (open-access available here) reporting that: "Ad36 [Human adenovirus 36] infection is associated with an increased risk of obesity development."Based on a meta-analysis of the available research literature examining whether Ad-36 - "a nonenveloped icosahedral virus comprised of double-stranded DNA and is one of 56 serotypes in 7 subgroups of human adenoviruses" - might........ Read more »
Shang Q, Wang H, Song Y, Wei L, Lavebratt C, Zhang F, & Gu H. (2014) Serological data analyses show that adenovirus 36 infection is associated with obesity: a meta-analysis involving 5739 subjects. Obesity (Silver Spring, Md.), 22(3), 895-900. PMID: 23804409
Rapid eye movement or REM sleep actively converts waking experiences into lasting memories and abilities in young brains reports a new study. The finding broadens the understanding of children’s sleep needs and calls into question the increasing use of REM-disrupting medications such as stimulants and antidepressants.
... Read more »
Michelle C. Dumoulin Bridi, Sara J. Aton, Julie Seibt, Leslie Renouard, Tammi Coleman1, & Marcos G. Frank. (2015) Rapid eye movement sleep promotes cortical plasticity in the developing brain. Science Advances. info:/10.1126/sciadv.1500105
The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. A group of researchers discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases.... Read more »
Nikolay A. Pestov, Nadezhda S. Gerasimova, Olga I. Kulaeva, & Vasily M. Studitsky. (2015) Structure of transcribed chromatin is a sensor of DNA damage. Science Advances. info:/10.1126/sciadv.1500021
When you smile at a party, your facial expression is emotionally consistent with the happy context and as a consequence other guests will in future be more likely to remember that they've seen your face before, and where you were when they saw you. That's according to a team of Italian researchers led by Stefania Righi who have explored how memory for a face is affected by the emotion shown on that face and the congruence between that emotional expression and its surrounding context.The research........ Read more »
Righi, S., Gronchi, G., Marzi, T., Rebai, M., & Viggiano, M. (2015) You are that smiling guy I met at the party! Socially positive signals foster memory for identities and contexts. Acta Psychologica, 1-7. DOI: 10.1016/j.actpsy.2015.05.001
MedicalResearch.com Interview with: Prof. Patrick L Kinney Ph.D. Professor of Environmental Health Sciences and Director, Columbia Climate and Health Program Mailman School of Public Health Columbia University, New York, NY Medical Research: What is the background for this study? Dr. Kinney: … Continue reading →
The post Warming Climate May Not Reduce Winter Mortality appeared first on MedicalResearch.com Medical Research Interviews and News.
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Prof. Patrick L Kinney Ph.D., & Professor of Environmental Health Sciences. (2015) Warming Climate May Not Reduce Winter Mortality. MedicalResearch.com. info:/
Can we learn without being aware of what we're learning? Many psychologists say that 'unconscious', or implicit, learning exists.
But in a new paper, London-based psychologists Vadillo, Konstantinidis, and Shanks call the evidence for this into question.
Vadillo et al. focus on one particular example of implicit learning, the contextual cueing paradigm. This involves a series of stimulus patterns, each consisting of a number of "L" shapes and one "T" shape in various orientations. For ... Read more »
Vadillo MA, Konstantinidis E, & Shanks DR. (2015) Underpowered samples, false negatives, and unconscious learning. Psychonomic bulletin . PMID: 26122896
MedicalResearch.com Interview with: Dr. F. Xavier Pi–Sunyer MD Division of Endocrinology and Obesity Research Center Columbia University, New York Medical Research: What is the background for this study? What are the main findings? Dr. Pi-Sunye: In a large randomized trial, … Continue reading →
The post Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients appeared first on MedicalResearch.com Medical Research Interviews and News.
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Dr. F. Xavier Pi-Sunyer MD, & Division of Endocrinology and Obesity Research Center. (2015) Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates George Washington University Medical Research: What is the background for this study? What are the main findings? Response: Many factors are associated with lower testosterone levels and … Continue reading →
The post Low Testosterone Linked To Obesity and Depression In Men appeared first on MedicalResearch.com Medical Research Interviews and News.
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Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates. (2015) Low Testosterone Linked To Obesity and Depression In Men. MedicalResearch.com. info:/
When you look at a kangaroo or a wallaby, it's obvious the animal is well built for bouncing around the outback. What may be less obvious is that its arms are built for fighting—if it's male, that is. Males of these species have disproportionately long arm bones. And the more brawling a species does, the more exaggerated the difference between the beefy-armed males and their normal-limbed mates.
To understand this evolutionary quirk, we'll need to review the rules of fighting in wallabie........ Read more »
Richards, H., Grueter, C., & Milne, N. (2015) Strong arm tactics: sexual dimorphism in macropodid limb proportions. Journal of Zoology. DOI: 10.1111/jzo.12264
by Rita Handrich in The Jury Room
Here’s another installment of things we think you might want to know but to which we don’t wish to devote an entire blog post. Keep reading to have tidbits worthy of sound bytes over drinks. The onset of ‘real’ adulthood Five years ago we were distressed to discover that middle age begins at 35 and […]
There is a “naive faith in the trustworthiness of brain imaging data”
“I’ve got proof I’m open-minded!”: Inventing racist roads not taken
Your online av........ Read more »
Hehman E, Flake JK, & Freeman JB. (2015) Static and Dynamic Facial Cues Differentially Affect the Consistency of Social Evaluations. Personality . PMID: 26089347
Myrick, J. (2015) Emotion regulation, procrastination, and watching cat videos online: Who watches Internet cats, why, and to what effect?. Computers in Human Behavior, 168-176. DOI: 10.1016/j.chb.2015.06.001
Animal models can be useful for understanding disease pathology and as preclinical models for drug testing. As BHD patients develop renal cell carcinomas (RCCs) of varied histologies, associated with a loss of FLCN, BHD animal models could be used to study of a wide range of renal cancer subtypes. Current BHD mouse models include kidney-specific Flcn-knockouts (Chen et al., 2008, Baba et al., 2008) and ubiquitous knockouts (Hasumi et al., 2009, Hartman et al., 2009, Hudon et al., 2010). The form........ Read more »
Chen J, Huang D, Rubera I, Futami K, Wang P, Zickert P, Khoo SK, Dykema K, Zhao P, Petillo D.... (2015) Disruption of tubular Flcn expression as a mouse model for renal tumor induction. Kidney international. PMID: 26083655
Adding some ‘worry time’ to your day could work better than pills.... Read more »
Koffel EA, Koffel JB, & Gehrman PR. (2015) A meta-analysis of group cognitive behavioral therapy for insomnia. Sleep medicine reviews, 6-16. PMID: 24931811
Sivertsen B, Omvik S, Pallesen S, Bjorvatn B, Havik OE, Kvale G, Nielsen GH, & Nordhus IH. (2006) Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA, 295(24), 2851-8. PMID: 16804151
A new research article shows that the ventral striatum includes a representation of the value attributed to potential choices in a gambling task, and of the decision eventually reached.... Read more »
Strait, C., Sleezer, B., & Hayden, B. (2015) Signatures of Value Comparison in Ventral Striatum Neurons. PLOS Biology, 13(6). DOI: 10.1371/journal.pbio.1002173
I was really rather happy to see the "preliminary evidence" reported by Rebecca Schmidt and colleagues  when it came to examining whether selected vitamin D metabolic gene variants might show linkage to autism spectrum disorder (ASD) based on data derived from the CHARGE initiative.For quite a while now I've discussed the various peer-reviewed science on the topic of vitamin D deficiency / insufficiency with autism in mind on this blog (see here and see here for example). Specifically, h........ Read more »
Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, & Tassone F. (2015) Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early human development, 91(8), 483-489. PMID: 26073892
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Foot Strike Pattern and Injury Rates... Read more »
Warr BJ, Fellin RE, Sauer SG, Goss DL, Frykman PN, & Seay JF. (2015) Characterization of Foot-Strike Patterns: Lack of an Association With Injuries or Performance in Soldiers. Military medicine, 180(7), 830-4. PMID: 26126256
MedicalResearch.com Interview with: Dr. Bahman Guyuron MD Cleveland and Lyndhurst, Ohio From the Department of Plastic Surgery, University Hospital Case Medical Center; and the American Migraine Center Medical Research: What is the background for this study? Dr. Guyuron: Through several … Continue reading →
The post Study Compares Two Surgical Techniques To Relieve Migraine Headaches appeared first on MedicalResearch.com Medical Research Interviews and News.
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Dr. Bahman Guyuron MD, & Cleveland and Lyndhurst. (2015) Study Compares Two Surgical Techniques To Relieve Migraine Headaches. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Chao Cheng, Ph.D. Assistant Professor Department of Genetics Institute for Quantitative Biomedical Sciences Geisel School of Medicine at Dartmouth Hanover NH, 03755 Medical Research: What is the background for this study? Dr. Cheng: Bladder cancer is a … Continue reading →
The post Biomarker Predicts Bladder Cancer Response To Treatment appeared first on MedicalResearch.com Medical Research Interviews and News.
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Chao Cheng, Ph.D., & Assistant Professor. (2015) Biomarker Predicts Bladder Cancer Response To Treatment. MedicalResearch.com. info:/
Physicists at the University of Sussex have found a way of using everyday technology found in kitchen microwaves and mobile telephones to bring quantum physics closer to helping solve enormous scientific problems that the most powerful of today’s supercomputers cannot even begin to embark upon.... Read more »
Weidt, S., Randall, J., Webster, S., Standing, E., Rodriguez, A., Webb, A., Lekitsch, B., & Hensinger, W. (2015) Ground-State Cooling of a Trapped Ion Using Long-Wavelength Radiation. Physical Review Letters, 115(1). DOI: 10.1103/PhysRevLett.115.013002
Biologically active molecules released by digesting bread and pasta can survive digestion and potentially pass through the gut lining, suggests new research. The study reveals the molecules released when real samples of bread and pasta are digested, providing new information for research into gluten sensitivity.... Read more »
Stuknytė, M., Maggioni, M., Cattaneo, S., De Luca, P., Fiorilli, A., Ferraretto, A., & De Noni, I. (2015) Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium. Food Research International, 208-214. DOI: 10.1016/j.foodres.2015.04.002
Research into how bacteria fight viruses has spurred a revolution in genetic engineering referred to as "CRISPR". CRISPR provides unprecedented ways to easily modify the genome of any living creature, including humans.... Read more »
Sander JD, & Joung JK. (2014) CRISPR-Cas systems for editing, regulating and targeting genomes. Nature biotechnology, 32(4), 347-55. PMID: 24584096
Garneau, J., Dupuis, M., Villion, M., Romero, D., Barrangou, R., Boyaval, P., Fremaux, C., Horvath, P., Magadán, A., & Moineau, S. (2010) The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature, 468(7320), 67-71. DOI: 10.1038/nature09523
Horie, M., Honda, T., Suzuki, Y., Kobayashi, Y., Daito, T., Oshida, T., Ikuta, K., Jern, P., Gojobori, T., Coffin, J.... (2010) Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature, 463(7277), 84-87. DOI: 10.1038/nature08695
Horvath, P., & Barrangou, R. (2010) CRISPR/Cas, the Immune System of Bacteria and Archaea. Science, 327(5962), 167-170. DOI: 10.1126/science.1179555
Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R., Church, G., Corn, J., Daley, G., Doudna, J., Fenner, M.... (2015) A prudent path forward for genomic engineering and germline gene modification. Science, 348(6230), 36-38. DOI: 10.1126/science.aab1028
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