Post List

  • June 11, 2015
  • 04:16 PM
  • 78 views

Noninvasive Prenatal Testing May Detect Maternal Cancer

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Prof. Joris Vermeesch Hoofd Moleculaire Cytogenetica Coordinator Genomics Core University of Leuven, University Hospitals Leuven, Belgium Medical Research: What is the background for this study? What are the main findings? Dr. Vermeesch: We developed a novel analysis … Continue reading →
The post Noninvasive Prenatal Testing May Detect Maternal Cancer appeared first on MedicalResearch.com Med........ Read more »

Prof. Joris Vermeesch, Hoofd Moleculaire Cytogenetica, & Coordinator Genomics Core. (2015) Noninvasive Prenatal Testing May Detect Maternal Cancer. MedicalResearch.com. info:/

  • June 11, 2015
  • 03:59 PM
  • 110 views

The curious case of Neisseria and the seven-carbon sugar

by Betty Zou in Eat, Read, Science

Neisseria gonorrhoeae releases a seven carbon sugar that activates HIV gene expression and functions as a pathogen associated molecular pattern. Here's the story of how it was discovered and why it could be helping Neisseria evade our immune system.... Read more »

Malott, R., Keller, B., Gaudet, R., McCaw, S., Lai, C., Dobson-Belaire, W., Hobbs, J., St. Michael, F., Cox, A., Moraes, T.... (2013) Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression. Proceedings of the National Academy of Sciences, 110(25), 10234-10239. DOI: 10.1073/pnas.1303738110  

Ryan G. Gaudet,, Anna Sintsova,, Carolyn M. Buckwalter,, Nelly Leung,, Alan Cochrane,, Jianjun Li,, Andrew D. Cox,, Jason Moffat,, & Scott D. Gray-Owen. (2015) Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity . Science, 1251-1255. info:/10.1126/science.aaa4921

  • June 11, 2015
  • 03:12 PM
  • 103 views

Milk proteins may protect against cardiovascular disease

by Dr. Jekyll in Lunatic Laboratories

The Maillard reaction is a chemical reaction between amino acids and reducing sugars that results in browned foods like seared steaks and toasted bread. When proteins and sugars are mixed together and heated, new chemical compounds are formed. Some are responsible for new flavors and some, according to a new study, may protect us against cardiovascular disease.... Read more »

  • June 11, 2015
  • 09:35 AM
  • 124 views

What’s the Answer? (pan-genome graphs)

by Mary in OpenHelix

This weeks highlighted discussion is the problem of pan-genome graphs, which are ways to represent the variation we find in genomes instead of a linear reference sequence view. I was really struggling with these concepts until I heard a talk at the #TRICON meeting recently. David Haussler had some really helpful visuals. I don’t have […]... Read more »

Benedict Paten, Adam Novak, & David Haussler. (2014) Mapping to a Reference Genome Structure. arXiv.org. arXiv: 1404.5010v1

Nguyen, N., Hickey, G., Zerbino, D., Raney, B., Earl, D., Armstrong, J., Kent, W., Haussler, D., & Paten, B. (2015) Building a Pan-Genome Reference for a Population. Journal of Computational Biology, 22(5), 387-401. DOI: 10.1089/cmb.2014.0146  

  • June 11, 2015
  • 08:58 AM
  • 117 views

Active hematopoietic sites in Drosophila Adult

by LolitikaMandal in the Node

Studies in the last decade have established Drosophila as the best invertebrate model to study hematopoiesis. Blood cell development in the fruitfly has been shown to have similarities to that of vertebrates both at the level of its origins and important signaling molecules necessary for their formation and differentiation (Evans et al., 2003). It was believed […]... Read more »

  • June 11, 2015
  • 08:00 AM
  • 91 views

The catch-22 of recording from identified cell populations

by Michael Patterson in ...And You Will Know Me By The Trail of Papers

Recording from individual cells in genetically identified populations is the hottest technique in systems neuroscience right now (I am, of course, totally biased since that's what I'm trying to do). To record from identified populations, you first choose a mouse line that expresses Cre driven by a cell-specific marker like D1R. Then you transduce those cells with floxed ChR2 or GCaMP so you can ... Read more »

Betley, J., Xu, S., Cao, Z., Gong, R., Magnus, C., Yu, Y., & Sternson, S. (2015) Neurons for hunger and thirst transmit a negative-valence teaching signal. Nature, 521(7551), 180-185. DOI: 10.1038/nature14416  

Jennings, J., Ung, R., Resendez, S., Stamatakis, A., Taylor, J., Huang, J., Veleta, K., Kantak, P., Aita, M., Shilling-Scrivo, K.... (2015) Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors. Cell, 160(3), 516-527. DOI: 10.1016/j.cell.2014.12.026  

  • June 11, 2015
  • 05:11 AM
  • 140 views

Higher vitamin D = reduced risk of depression?

by Paul Whiteley in Questioning Answers

"These results support the hypothesis that higher serum 25(OH)D concentrations protect against depression even after adjustment for a large number of sociodemographic, lifestyle and metabolic factors."That was the conclusion reached by Tuija Jääskeläinen and colleagues [1] who analysed data from several thousands of people (men and women aged between 30 -79 years old) included as part of the Finnish Health 2000 survey. Alongside assaying for serum levels of 25(OH)D - 25-hydroxy vitamin D........ Read more »

Jääskeläinen T, Knekt P, Suvisaari J, Männistö S, Partonen T, Sääksjärvi K, Kaartinen NE, Kanerva N, & Lindfors O. (2015) Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression. The British journal of nutrition, 113(9), 1418-26. PMID: 25989997  

  • June 10, 2015
  • 08:37 PM
  • 70 views

Treatment With TNF-α inhibitors Raises Short Term Risk Of Infection in Inflammatory Bowel Disease

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Nynne Nyboe Andersen, MD, PhD student Department of Epidemiology Research Statens Serum Institut Copenhagen, Denmark Medical Research: What is the background for this study? What are the main findings? Dr. Andersen: The use of TNF-α inhibitors, including … Continue reading →
The post Treatment With TNF-α inhibitors Raises Short Term Risk Of Infection in Inflammatory Bowel Disease appeared f........ Read more »

Nynne Nyboe Andersen, MD, PhD student Department of Epidemiology Research, Statens Serum Institut, & Copenhagen, Denmark. (2015) Treatment With TNF-α inhibitors Raises Short Term Risk Of Infection in Inflammatory Bowel Disease. MedicalResearch.com. info:/

  • June 10, 2015
  • 08:10 PM
  • 70 views

Lack of Random Allocation of Participants May Make Observational Research Misleading

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Andrew Grey, MD Department of Medicine University of Auckland Auckland, New Zealand Medical Research: What is the background for this study? What are the main findings? Dr. Grey: Observational research is commonly conducted and often published in prominent medical … Continue reading →
The post Lack of Random Allocation of Participants May Make Observational Research Misleading appeared firs........ Read more »

Andrew Grey, MD, Department of Medicine, University of Auckland, & Auckland, New Zealand. (2015) Lack of Random Allocation of Participants May Make Observational Studies Misleading. MedicalResearch.com. info:/

  • June 10, 2015
  • 07:21 PM
  • 97 views

Most Patients With Atrial Fibrillation Are Symptomatic and Have Impaired Quality of Life

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: James V. Freeman MD, MPH, MS Yale University School of Medicine New Haven, CT Medical Research: What is the background for this study? What are the main findings? Dr. Freeman: Atrial fibrillation (AF) substantially increases the risk … Continue reading →
The post Most Patients With Atrial Fibrillation Are Symptomatic and Have Impaired Quality of Life appeared first on MedicalResearch.com Medi........ Read more »

James V. Freeman MD, MPH, MS, Yale University School of Medicine, & New Haven, CT. (2015) Most Patients With Atrial Fibrillation Symptomatic and Have Impaired Quality of Life. MedicalResearch.com. info:/

  • June 10, 2015
  • 06:15 PM
  • 109 views

New drug can clear all psoriasis symptoms

by Dr. Jekyll in Lunatic Laboratories

Good news for anyone who has psoriasis, a University of Manchester led trial of a new drug has resulted in 40 percent of people showing a complete clearance of psoriatic plaques after 12 weeks of treatment and over 90 percent showing improvement. The research tested 2,500 people with psoriasis. Half were given a new drug – ixekizumab – either once every two or four weeks. The other half were given a placebo or a widely used drug for psoriasis called etanercept.... Read more »

Prof Christopher E M, Griffiths, MD, Prof Kristian Reich, MD, Prof Mark Lebwohl, MD, Prof Peter van de Kerkhof, MD, Prof Carle Paul, MD, Alan Menter, MD, Gregory S Cameron, PhD, Janelle Erickson, PhD, Lu Zhang, MS.... (2015) Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials . Lancet. DOI: http://dx.org/10.1016/S0140-6736(15)60125-8  

  • June 10, 2015
  • 05:44 PM
  • 125 views

First functional, synthetic immune organ with controllable antibodies created by engineers

by Dr. Jekyll in Lunatic Laboratories

Cornell University engineers have created a functional, synthetic immune organ that produces antibodies and can be controlled in the lab, completely separate from a living organism. The engineered organ has implications for everything from rapid production of immune therapies to new frontiers in cancer or infectious disease research.... Read more »

Purwada, A., Jaiswal, M., Ahn, H., Nojima, T., Kitamura, D., Gaharwar, A., Cerchietti, L., & Singh, A. (2015) Ex vivo Engineered Immune Organoids for Controlled Germinal Center Reactions. Biomaterials. DOI: 10.1016/j.biomaterials.2015.06.002  

  • June 10, 2015
  • 05:12 PM
  • 58 views

Early Autism Intervention Produces Long Term Benefits

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Annette Estes, Ph.D. Research Associate Professor of Speech and Hearing Sciences Adjunct Research Associate Professor of Psychology Director, University of Washington Autism Center Susan & Richard Fade Endowed Chair Center on Human Development and Disability University of … Continue reading →
The post Early Autism Intervention Produces Long Term Benefits appeared first on MedicalResearch......... Read more »

MedicalResearch.com Interview with: Annette Estes, Ph.D., Research Associate Professor of Speech and Hearing Sciences, Adjunct Research Associate Professor of Psychology, Director, University of Washington Autism Center, Susan , Center on Human Development and Disability, & University of Washington. (2015) Early Autism Intervention Produces Long Term Benefits . MedicalResearch.com. info:/

  • June 10, 2015
  • 04:56 PM
  • 69 views

Social Support From Friends and Family Linked To Lower Mortality

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Katie Becofsky Ph.D. Weight Control and Diabetes Research Center The Miriam Hospital Providence, RI Medical Research: What is the background for this study? What are the main findings? Dr. Becofsky: Previous research has provided clear evidence of … Continue reading →
The post Social Support From Friends and Family Linked To Lower Mortality appeared first on MedicalResearch.com Medical Resear........ Read more »

Katie Becofsky Ph.D., Weight Control and Diabetes Research Center, The Miriam Hospital, & Providence, RI. (2015) Social Support From Friends and Family Linked To Lower Mortality. MedicalResearch.com. info:/

  • June 10, 2015
  • 02:26 PM
  • 62 views

Blood Pressure Medication ARBs Should Be Resumed As Soon As Possible After Surgery

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Susan Ming Lee, MD, FRCPC, MAS (Clinical Research) Clinical Instructor, Dept. of Anesthesia and Perioperative Care University of California, San Francisco Medical Research: What are the main findings? Dr. Lee: Angiotensin receptor blockers (often referred to as … Continue reading →
The post Blood Pressure Medication ARBs Should Be Resumed As Soon As Possible After Surgery appeared first on Me........ Read more »

Susan Ming Lee, MD, FRCPC, MAS (Clinical Research), Clinical Instructor, Dept. of Anesthesia and Perioperative Care, & University of California, San Francisco. (2015) Blood Pressure Medication ARBs Should Be Resumed As Soon As Possible After Surgery. MedicalResearch.com. info:/

  • June 10, 2015
  • 01:38 PM
  • 58 views

Pediatric Hospitalizations For Children Dropped Almost 90% After Rotavirus Vaccine Implemented

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Eyal Leshem, MD Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia Medical Research: What is the background for this study? What are the main findings? Response: Routine vaccination of US children to protect against … Continue reading →
The post Pediatric Hospitalizations For Children Dropped Almost 90% After Rotavirus Vaccine Implemented appeared fi........ Read more »

Eyal Leshem, MD, Division of Viral Diseases,, US Centers for Disease Control and Prevention,, & Atlanta, Georgia. (2015) Pediatric Hospitalizations For Children Dropped Almost 90% After Rotavirus Vaccine Implemented. MedicalResearch.com. info:/

  • June 10, 2015
  • 12:58 PM
  • 119 views

Brain Default Network in Psychotic Bipolar Disorder

by William Yates, M.D. in Brain Posts

In a previous post I reviewed a summary of research related to genetics and improved diagnosis in bipolar disorder.One key point in this review was a highlight of the promise for integrating genetic with imaging research in bipolar disorder and other neuropsychiatric disorders.An example of this type of integrated research has been recently published in PNAS by a group of Yale University, the University of New Mexico and the University of Texas Southwestern Medical Center.This study used functio........ Read more »

Meda SA, Ruaño G, Windemuth A, O'Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E.... (2014) Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 111(19). PMID: 24778245  

  • June 10, 2015
  • 12:26 PM
  • 58 views

Cognitive Therapy May Be Safe and Effective For Chronic Insomnia

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Dr David Cunnington Sleep Physician & Director Melbourne Sleep Disorders Centre East Melbourne Australia Medical Research: What is the background for this study? What are the main findings? Response: Insomnia is a very common problem with 15-20% … Continue reading →
The post Cognitive Therapy May Be Safe and Effective For Chronic Insomnia appeared first on MedicalResearch.com Medical Rese........ Read more »

Dr David Cunnington Sleep Physician , Melbourne Sleep Disorders Centre, & East Melbourne Australia. (2015) Cognitive Therapy May Be Safe and Effective For Chronic Insomnia. MedicalResearch.com. info:/

  • June 10, 2015
  • 12:08 PM
  • 48 views

CDC Study Finds No Pattern Suggesting Vaccines Contributed To Or Caused Deaths

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Dr. Pedro Moro, MD, MPH Immunization Safety Office Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta, GA 3033 Medical Research: What is the background for this study? What are the main findings? Response: … Continue reading →
The post CDC Study Finds No Pattern Suggesting Vaccines Contributed To Or Caused Deaths appeared first on MedicalResearch.com M........ Read more »

Dr. Pedro Moro, MD, MPH, Immunization Safety Office, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, & Atlanta, GA 3033. (2015) CDC Study Finds No Pattern Suggesting Vaccines Contributed To Or Caused Deaths. MedicalResearch.com. info:/

  • June 10, 2015
  • 10:28 AM
  • 39 views

Research Into Many Dermatology Disorders Underfunded

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Chante Karimkhani MD Columbia University College of Physicians and Surgeons, New York, New York, Erika Hagstrom MD Loyola University of Chicago Stritch School of Medicine, Maywood, Illinois Robert Dellavalle MD, PhD, MPH Department of Dermatology, University of … Continue reading →
The post Research Into Many Dermatology Disorders Underfunded appeared first on MedicalResearch.com Medical Rese........ Read more »

MedicalResearch.com Interview with:, Chante Karimkhani MD, & Columbia University College of Physicians and Surgeons, New York, New York,. (2015) Research Into Many Dermatology Disorders Underfunded. MedicalResearch.com. info:/

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