I talked about ESSENCE - Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations - only yesterday (see here) and here I am covering the topic again on this blog. There is good reason however that this concept appears once more, as I draw your attention to the paper by Anne-Katrin Kantzer and colleagues  and the specific observation that: "Co-existence with other conditions was the rule" when it comes to the diagnosis of autism.OK, it's nothing new to say that the l........ Read more »
Kantzer, A., Fernell, E., Westerlund, J., Hagberg, B., Gillberg, C., & Miniscalco, C. (2016) Young children who screen positive for autism: Stability, change and “comorbidity” over two years. Research in Developmental Disabilities. DOI: 10.1016/j.ridd.2016.10.004
ESSENCE referred to in the title of this post concerns 'Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations', a concept championed by the ever-intrepid Prof. Christopher Gillberg and colleagues. Combined with some rather important discussions about the research validity of the concept of a singular 'autism' (see here) [part of the ESSENCE issues described] I'm drawn to quite a few of the proposals put forward by this research group it has to be said.It is with ESSENCE ........ Read more »
Baeza-Velasco C, Grahame R, & Bravo JF. (2016) A connective tissue disorder may underlie ESSENCE problems in childhood. Research in developmental disabilities. PMID: 27802895
The emergence of therapy resistance in tumours can be described using Darwinian evolutionary theory. This post provides a brief description of Darwin's theory. The next post will apply the theory to tumour development.... Read more »
Darwin, Charles. (1876) The Origin of Species By Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life. Cambridge University Press. DOI: 10.1017/CBO9780511694295
AG McCluskey. (2016) Damn You Darwin! Pt1: Cat . Zongo's Cancer Diaries. info:/
the infection of both mice and non-human primates with various ZIKV strains including the original ZIKV MR766 strain as well as strains from Asia (ZIKV FSS13025), Oceania (ZIKV H/PF/2013) and the Americas (ZIKV Paraiba 2015) as well as the infection of human placenta explants (ZIKV MR766 and ZIKV Nica-1/-2 2016) suggest that ZIKV can cross the placenta probably by infecting maternal cytotrophoblast cells (CTB) and maternal decidual fibroblast cells combined with placental injury due to the relea........ Read more »
Huang X, Yue Y, Li D, Zhao Y, Qiu L, Chen J, Pan Y, Xi J, Wang X, Sun Q.... (2016) Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy. Scientific reports, 22303. PMID: 26923481
Nour AM, Li Y, Wolenski J, & Modis Y. (2013) Viral membrane fusion and nucleocapsid delivery into the cytoplasm are distinct events in some flaviviruses. PLoS pathogens, 9(9). PMID: 24039574
Panyasrivanit M, Greenwood MP, Murphy D, Isidoro C, Auewarakul P, & Smith DR. (2011) Induced autophagy reduces virus output in dengue infected monocytic cells. Virology, 418(1), 74-84. PMID: 21813150
Dai L, Song J, Lu X, Deng YQ, Musyoki AM, Cheng H, Zhang Y, Yuan Y, Song H, Haywood J.... (2016) Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody. Cell host , 19(5), 696-704. PMID: 27158114
Charles AS, & Christofferson RC. (2016) Utility of a Dengue-Derived Monoclonal Antibody to Enhance Zika Infection In Vitro. PLoS currents. PMID: 27660733
Dejnirattisai W, Supasa P, Wongwiwat W, Rouvinski A, Barba-Spaeth G, Duangchinda T, Sakuntabhai A, Cao-Lormeau VM, Malasit P, Rey FA.... (2016) Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nature immunology, 17(9), 1102-8. PMID: 27339099
Chan JF, Yip CC, Tsang JO, Tee KM, Cai JP, Chik KK, Zhu Z, Chan CC, Choi GK, Sridhar S.... (2016) Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs. Emerging microbes . PMID: 27553173
Sapparapu G, Fernandez E, Kose N, Cao B, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T.... (2016) Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature. PMID: 27819683
Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Wang C, Fang-Hoover J, Harris E, & Pereira L. (2016) Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission. Cell host , 20(2), 155-66. PMID: 27443522
More of the same...... Read more »
Fuller, J., Buckley, J., Tsiros, M., Brown, N., & Thewlis, D. (2016) Redistribution of Mechanical Work at the Knee and Ankle Joints During Fast Running in Minimalist Shoes. Journal of Athletic Training. DOI: 10.4085/1062-6050-51.12.05
It's been quite a week hasn't it? Indeed for quite a few people it's been a stressful few days so perhaps timely that I'm talking about the 'attenuation of stress' in today's post.Despite the relatively small sample size included in the paper by by AP Allen and colleagues  there is something rather tantalising about their results suggesting that in healthy volunteers "consumption of B. longum [Bifidobacterium longum 1714] 1714 is associated with reduced stress and improved memo........ Read more »
Allen AP, Hutch W, Borre YE, Kennedy PJ, Temko A, Boylan G, Murphy E, Cryan JF, Dinan TG, & Clarke G. (2016) Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Translational psychiatry, 6(11). PMID: 27801892
Renal cell carcinoma (RCC) is by far the most common type of kidney cancer and it can be caused by genetic conditions such as BHD (Randall et al., 2014). BHD patients can develop multiple kidney tumours. In most cases these tumours can be surgically removed. However, surgery and traditional chemotherapies can leave patients with reduced renal function and at risk of relapse. In addition, advanced or metastatic RCC is difficult to treat with surgery. Therefore, the development and improvement o........ Read more »
Randall, J., Millard, F., & Kurzrock, R. (2014) Molecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art. Cancer and Metastasis Reviews, 33(4), 1109-1124. DOI: 10.1007/s10555-014-9533-1
by Piter Kehoma Boll Most of you likely know what diatoms are, microscopic algae with a silica shell that are very abundant in the world’s oceans and one of the main oxygen producers. You may have seen images like the … Continue reading →... Read more »
Ianora, A., Poulet, S., Miralto, A., & Grottoli, R. (1996) The diatom Thalassiosira rotula affects reproductive success in the copepod Acartia clausi. Marine Biology, 125(2), 279-286. DOI: 10.1007/BF00346308
Krawiec, R. (1982) Autecology and clonal variability of the marine centric diatom Thalassiosira rotula (Bacillariophyceae) in response to light, temperature and salinity. Marine Biology, 69(1), 79-89. DOI: 10.1007/BF00396964
The important Doctor-Patient relationshipIn a slight departure from the typical material discussed on this blog, I want to briefly direct readers to the paper by (Prof) Paul Aveyard and colleagues  and results suggesting that: "A behaviourally-informed, very brief, physician-delivered opportunistic intervention is acceptable to patients and an effective way to reduce population mean weight."The title of this post comes from some of the media coverage of the Aveyard study summarising how ........ Read more »
Aveyard, P., Lewis, A., Tearne, S., Hood, K., Christian-Brown, A., Adab, P., Begh, R., Jolly, K., Daley, A., Farley, A.... (2016) Screening and brief intervention for obesity in primary care: a parallel, two-arm, randomised trial. The Lancet. DOI: 10.1016/S0140-6736(16)31893-1
I've blogged about my fair share of scientific papers over the years, but this is a new one: a paper about me.
Writing in Science and Engineering Ethics, author Jaime A. Teixeira da Silva discusses the question of Are Pseudonyms Ethical in (Science) Publishing? Neuroskeptic as a Case Study
Teixeira da Silva, a plant scientist and frequent poster on PubPeer amongst other forums, opens with the following:
There is a prominent blogger called Neuroskeptic who has a web-site and even a... Read more »
Teixeira da Silva, J. (2016) Are Pseudonyms Ethical in (Science) Publishing? Neuroskeptic as a Case Study. Science and Engineering Ethics. DOI: 10.1007/s11948-016-9825-7
Gender stereotypes are powerful things and when your client has broken gender stereotypes and broken trust with others, they need to go beyond mere apology. First, a bit about what gender stereotypes are: Women are expected to be benevolent and concerned about others while men are expected to be confident, competitive and independent. Go against […]
Simple Jury Persuasion: When your Muslim female client wears a head-covering
Simple Jury Persuasion: “I transgressed. Pleas........ Read more »
Highlights of the month include a Special Issue on Blastocystis appearing in Parasitology International, a study of mitochondrial genomes, relationships between gut parasites and gut bacteria, and a announcement of an EMBO anaerobic protist conference next year in the UK.... Read more »
Dogruman-Al F, Stensvold CR, & Yoshikawa H. (2016) Editorial - PAR INT - special issue on Blastocystis. Parasitology international, 65(6 Pt B), 749. PMID: 27742000
Jacob AS, Andersen LO, Pavinski Bitar P, Richards VP, Shah S, Stanhope MJ, Stensvold CR, & Clark CG. (2016) Blastocystis mitochondrial genomes appear to show multiple independent gains and losses of start and stop codons. Genome biology and evolution. PMID: 27811175
Iebba V, Santangelo F, Totino V, Pantanella F, Monsia A, Di Cristanziano V, Di Cave D, Schippa S, Berrilli F, & D'Alfonso R. (2016) Gut microbiota related to Giardia duodenalis, Entamoeba spp. and Blastocystis hominis infections in humans from Côte d'Ivoire. Journal of infection in developing countries, 10(9), 1035-1041. PMID: 27694739
Smith DR. (2016) The past, present and future of mitochondrial genomics: have we sequenced enough mtDNAs?. Briefings in functional genomics, 15(1), 47-54. PMID: 26117139
As I am trying to finalize the manuscript for the second revised edition of my 2011 book Intercultural Communication: A...... Read more »
Markus, A. (2016) Australians Today: The Australia@2015 Scanlon Foundation Survey. Scanlon Foundation. info:/
In a year of impossible things...I was rather interested to read the recent paper by Renee Goodwin and colleagues  observing that: "Atopy appears to be associated with increased vulnerability to affective and anxiety problems, compared to youth without atopy."Atopy, referring to a predisposition to developing allergic diseases such as eczema, asthma and/or hayfever, is something on the 'up' in research terms when it comes to aspects of psychiatry and/or developmental outcomes (see here f........ Read more »
Goodwin RD, Robinson M, Sly PD, & Holt PG. (2016) Childhood atopy and mental health: a prospective, longitudinal investigation. Psychological medicine, 1-9. PMID: 27762174
I am weathering the US election in Tampa, Florida. For this week, I am back at the Moffitt Cancer Center to participate in the 6th annual IMO Workshop. The 2016 theme is one of the biggest challenges to current cancer treatment: therapy resistance. All five teams participating this year are comfortable with the evolutionary view […]... Read more »
Ball M, List AF, & Padron E. (2016) When clinical heterogeneity exceeds genetic heterogeneity: thinking outside the genomic box in chronic myelomonocytic leukemia. Blood. PMID: 27707735
A person’s subjective social status reflects how they rank themselves relative to others in their community. Social status can be considered to be a psychological dimension of social class and socioeconomic status, and it has been shown to be positively related to mental health: The higher one’s perceived social status, the better one’s mental health. However, the process underlying this relation is unclear. In some recent research, my colleagues and I considered social contact........ Read more »
Rubin, M., Evans, O., & Wilkinson, R. (2016) A Longitudinal Study of the Relations Among University Students' Subjective Social Status, Social Contact with University Friends, and Mental Health and Well-Being. Journal of Social and Clinical Psychology, 35(9), 722-737. DOI: 10.1521/jscp.2016.35.9.722
Cats make good use of added vertical space, study shows.A study by Emma Desforges (Waltham Centre for Pet Nutrition) et al finds that adding a vertical screen is good enrichment for cats. And while the study used cats that live at the Waltham research centre, the results suggest pet cats could benefit too.The scientists took an Ikea bookcase called Kallax in which the shelves are subdivided. They put half the backing on one side and half on the other, so that some shelves faced one way and the r........ Read more »
Desforges, E., Moesta, A., & Farnworth, M. (2016) Effect of a shelf-furnished screen on space utilisation and social behaviour of indoor group-housed cats (Felis silvestris catus). Applied Animal Behaviour Science, 60-68. DOI: 10.1016/j.applanim.2016.03.006
Participants with rear foot valgus appear to have diminished blood flow to the Achilles in comparison to normal rear foot individuals. More research is needed to determine how we can clinically intervene.... Read more »
Karzis, K., Kalogeris, M., Mandalidis, D., Geladas, N., Karteroliotis, K., & Athanasopoulos, S. (2016) The effect of foot overpronation on Achilles tendon blood supply in healthy male subjects. Scandinavian Journal of Medicine . DOI: 10.1111/sms.12722
"Many individuals with ASD [autism spectrum disorder] have a distinctive behavioral presentation that is recognizable within moments, a phenomenon we call "frank" ASD." So said the paper by Ashley de Marchena & Judith Miller  who carried out an "empirical study of frank ASD" and by the looks of my Twitter feed when I initially posted about this study, there are quite a few varied opinions about the concept of 'frank' autism.Although 'frank autism' makes up a significant portion ........ Read more »
de Marchena, A., & Miller, J. (2016) “Frank” presentations as a novel research construct and element of diagnostic decision-making in autism spectrum disorder. Autism Research. DOI: 10.1002/aur.1706
Do you find gruyère gross? Are you repelled by roquefort?
Neuroscientists are now investigating why this might be. A new paper claims to reveal The Neural Bases of Disgust for Cheese.
French (heh) researchers Jean-Pierre Royet and colleagues used fMRI to scan 15 people who liked cheese and 15 who "hated" it. During the scan, the participants were shown images of cheese and were exposed to cheese odors.
The six neuro-cheeses were blue cheese, cheddar, goat cheese, gruyère, parmesan, ... Read more »
Royet JP, Meunier D, Torquet N, Mouly AM, & Jiang T. (2016) The Neural Bases of Disgust for Cheese: An fMRI Study. Frontiers in human neuroscience, 511. PMID: 27799903
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