Post List

  • August 16, 2016
  • 04:36 AM
  • 221 views

Group A Streptococcal infections and paediatric neuropsychiatric disorders: Taiwan style

by Paul Whiteley in Questioning Answers

There they go again. Taiwan and their 'big data' publishing, yet again, some rather interesting population-based research trends derived from data from the National Health Insurance Research Database (NHIRD).This time around it is the paper by Han-Cheng Wang and colleagues [1] and the hypothesis to evaluate the "association between group A streptococcal (GAS) infections and the risks of developing tic disorders, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disord........ Read more »

  • August 15, 2016
  • 02:44 PM
  • 299 views

Prostitution has gone online -- and pimps are thriving

by Dr. Jekyll in Lunatic Laboratories

With the sale of sex shifting online, today's pimps are avoiding police detection by using underground websites, social media, mobile apps and even by hiding their ads on mainstream sites such as Craigslist and Backpage. In a first-of-its-kind study, criminologists interviewed 71 pimps in Atlanta and Chicago to determine how their marketing decisions are influenced by police enforcement of online prostitution.

... Read more »

  • August 15, 2016
  • 04:09 AM
  • 231 views

Offending behaviour and ADHD

by Paul Whiteley in Questioning Answers

"Although some associations between ADHD [attention-deficit hyperactivity disorder] and offending may be accounted for by co-morbidity with substance use disorders, early onset of offending and repeated violent offending appear to be directly related to ADHD."That was the conclusion reached by Jan Román-Ithier and colleagues [1] reporting on their study designed to "examine correlates of childhood ADHD symptoms among prisoners." Based on a sample adult prison population (N=1179) where........ Read more »

  • August 14, 2016
  • 05:40 PM
  • 241 views

Exercise can tackle symptoms of schizophrenia

by Dr. Jekyll in Lunatic Laboratories

Aerobic exercise can significantly help people coping with the long-term mental health condition schizophrenia, according to a new study. Through combining data from 10 independent clinical trials with a total of 385 patients with schizophrenia, Joseph Firth found that around 12 weeks of aerobic exercise training can significant improve patients' brain functioning.

... Read more »

  • August 13, 2016
  • 02:43 PM
  • 295 views

Intestinal flora effects drug response

by Dr. Jekyll in Lunatic Laboratories

Intestinal flora has multiple influences on human health, but researchers have revealed that it is also likely to have an effect on the body's response to drugs. Recent research suggests that changes in the intestinal flora, caused by antibacterial and antibiotic drugs or individual differences between people, may have an effect on a person's response to drugs including side effects. The research focused on the changes in proteins due to the condition of intestinal flora that affect th........ Read more »

  • August 13, 2016
  • 03:26 AM
  • 316 views

Inflammation is part of Gulf War Syndrome

by Paul Whiteley in Questioning Answers

Although mostly trying to avoid any politics-talk on this blog I am going to make some reference to it in this post set in the context of the Persian Gulf War otherwise known at the First Iraq War.The recent publication of the Chilcot report describing the case for the UK's involvement in the 2003 Iraq War (the second Iraq War) has further lit up an already illuminating year in British politics, by perhaps adding fuel to the notion that 'finishing the job' might have been an ........ Read more »

Johnson GJ, Slater BC, Leis LA, Rector TS, & Bach RR. (2016) Blood Biomarkers of Chronic Inflammation in Gulf War Illness. PloS one, 11(6). PMID: 27352030  

  • August 12, 2016
  • 03:37 PM
  • 337 views

Sugar addiction: Discovery of a brain sugar switch

by Dr. Jekyll in Lunatic Laboratories

Researchers have discovered that our brain actively takes sugar from the blood. Prior to this, researchers around the world had assumed that this was a purely passive process. An international team reports that transportation of sugar into the brain is regulated by so-called glial cells that react to hormones such as insulin or leptin; previously it was thought that this was only possible for neurons.

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García-Cáceres, C., Quarta, C., Varela, L., Gao, Y., Gruber, T., Legutko, B., Jastroch, M., Johansson, P., Ninkovic, J., Yi, C.... (2016) Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell, 166(4), 867-880. DOI: 10.1016/j.cell.2016.07.028  

  • August 12, 2016
  • 07:00 AM
  • 147 views

Friday Fellow: Jataí Bee

by Piter Boll in Earthling Nature

by Piter Kehoma Boll Certainly the most widespread, adaptable and well-known honey-producing bee is Apis melifera, commonly known as honeybee for obvious reasons. But there are a lot of other honey makers all over the world. Today I’m going to present … Continue reading →... Read more »

  • August 12, 2016
  • 06:52 AM
  • 327 views

Discovering a glaring error in a research paper – a personal account

by Richard Kunert in Brain's Idea

New York Magazine has published a great article about how grad student Steven Ludeke tried to correct mistakes in the research of Pete Hatemi and Brad Verhulst. Overall, Ludeke summarises his experience as ‘not recommendable’. Back in my undergraduate years I spotted an error in an article by David DeMatteo and did little to correct it. […]... Read more »

  • August 12, 2016
  • 05:10 AM
  • 238 views

Simulation study suggests that mutations induce conformational changes in FLCN - possible cause of Birt-Hogg-Dubé syndrome

by Joana Guedes in BHD Research Blog

Germline mutations of the folliculin gene are normally responsible for Birt–Hogg–Dubé (BHD) syndrome. The 3D structure of the C-terminal domain of folliculin (FLCN), folliculin-CT, has been previously determined (Nookala et al., 2012). FLCN is a tumor suppressor and a guanine nucleotide exchange factor (GEF) for Rab35. GEF activity of FLCN towards its GTPase might be essential for cellular processes. Most of the reported FLCN mutations lead to the BHD phenotype (Lim et al., 20........ Read more »

  • August 12, 2016
  • 04:22 AM
  • 285 views

Anti-psychotics for non-psychotic issues

by Paul Whiteley in Questioning Answers

A bit of a lazy post for you today with lots of quotes based on the findings reported by Ragnar Nesvåg and colleagues [1] asking some important questions about 'off-label' use of antipsychotics.Drawing on population-based data from Norway concerning "which substances, and for which mental disorder diagnoses, antipsychotic drugs were prescribed to 0–18-year-old boys and girls" the conclusions drawn make for some interesting reading.So: "In total, 0.18% of Norwegian children and adolescent........ Read more »

Nesvåg, R., Hartz, I., Bramness, J., Hjellvik, V., Handal, M., & Skurtveit, S. (2016) Mental disorder diagnoses among children and adolescents who use antipsychotic drugs. European Neuropsychopharmacology. DOI: 10.1016/j.euroneuro.2016.07.001  

  • August 11, 2016
  • 08:30 PM
  • 281 views

Acupuncture vs intravenous morphine in the management of acute pain in the ED

by Rogue Medic in Rogue Medic

Should we have people providing "fake" acupuncture in the Emergency Department?

If so, how should we do this?

Since it is not the acupuncture, but the patient's reaction to the "ceremony of the placebo" that appears to be providing the pain relief, how many different ways might we vary the "treatment" to improve the placebo effect?... Read more »

Grissa, M., Baccouche, H., Boubaker, H., Beltaief, K., Bzeouich, N., Fredj, N., Msolli, M., Boukef, R., Bouida, W., & Nouira, S. (2016) Acupuncture vs intravenous morphine in the management of acute pain in the ED. The American Journal of Emergency Medicine. DOI: 10.1016/j.ajem.2016.07.028  

Espay, A., Norris, M., Eliassen, J., Dwivedi, A., Smith, M., Banks, C., Allendorfer, J., Lang, A., Fleck, D., Linke, M.... (2015) Placebo effect of medication cost in Parkinson disease: A randomized double-blind study. Neurology, 84(8), 794-802. DOI: 10.1212/WNL.0000000000001282  

Ee, C., Xue, C., Chondros, P., Myers, S., French, S., Teede, H., & Pirotta, M. (2016) Acupuncture for Menopausal Hot Flashes. Annals of Internal Medicine, 164(3), 146. DOI: 10.7326/M15-1380  

Cherkin, D., Sherman, K., Avins, A., Erro, J., Ichikawa, L., Barlow, W., Delaney, K., Hawkes, R., Hamilton, L., Pressman, A.... (2009) A Randomized Trial Comparing Acupuncture, Simulated Acupuncture, and Usual Care for Chronic Low Back Pain. Archives of Internal Medicine, 169(9), 858. DOI: 10.1001/archinternmed.2009.65  

Goldman, R., Stason, W., Park, S., Kim, R., Schnyer, R., Davis, R., Legedza, A., & Kaptchuk, T. (2008) Acupuncture for Treatment of Persistent Arm Pain Due to Repetitive Use. The Clinical Journal of Pain, 24(3), 211-218. DOI: 10.1097/AJP.0b013e31815ec20f  

  • August 11, 2016
  • 02:04 PM
  • 276 views

Targeting the gut-brain connection can impact immunity

by Dr. Jekyll in Lunatic Laboratories

There's a reason it's called a gut feeling. The brain and the gut are connected by intricate neural networks that signal hunger and satiety, love and fear, even safety and danger. These networks employ myriad chemical signals that include dopamine, a powerful neurotransmitter most famous for its role in reward and addiction.

... Read more »

Xiou Cao, & Alejandro Aballay. (2016) Neural inhibition of dopaminergic signaling enhances immunity in a cell non-autonomous manner. Current Biology. info:/http://dx.doi.org/10.1016/j.cub.2016.06.036

  • August 11, 2016
  • 08:41 AM
  • 357 views

Who made the Piltdown man? Inside one of science’s most (in)famous hoaxes

by gdw in FictionalFieldwork

There was always that nagging feeling of not being accepted, of whispers behind his back. They pretended to be open-minded, but in reality not belonging to the group of professionals was reason enough to dismiss his work and findings. In their eyes, he was just a solicitor. A hobbyist. He was tolerated, but their derision […]... Read more »

De Groote, I., Flink, L., Abbas, R., Bello, S., Burgia, L., Buck, L., Dean, C., Freyne, A., Higham, T., Jones, C.... (2016) New genetic and morphological evidence suggests a single hoaxer created ‘Piltdown man’. Royal Society Open Science, 3(8), 160328. DOI: 10.1098/rsos.160328  

  • August 11, 2016
  • 04:35 AM
  • 319 views

Induced labour and autism (again)

by Paul Whiteley in Questioning Answers

"In this nationwide sample of live births we observed no association between induction of labor and offspring ASD [autism spectrum disorder] within sibling comparison. Our findings suggest that concern for ASD should not factor into the clinical decision about whether to induce labor."So said the findings reported by Anna Sara Oberg and colleagues [1] supposedly providing some reassurance to mums-to-be and other groups around the likelihood of offspring autism when birth or l........ Read more »

Oberg, A., D’Onofrio, B., Rickert, M., Hernandez-Diaz, S., Ecker, J., Almqvist, C., Larsson, H., Lichtenstein, P., & Bateman, B. (2016) Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders. JAMA Pediatrics. DOI: 10.1001/jamapediatrics.2016.0965  

  • August 10, 2016
  • 11:05 PM
  • 259 views

Size of female-built nests affects how males act

by Emily Makowski in Sextraordinary!

Last week, I discussed how male quality in birds may be related to their song. How do males evaluate females in return? The answer may lie in their nests.... Read more »

  • August 10, 2016
  • 01:30 PM
  • 280 views

Is depression in parents, grandparents linked to grandchildren's depression?

by Dr. Jekyll in Lunatic Laboratories

If you read my blog often, it's no surprise I suffer from PTSD, depression, and anxiety issues. Maybe it's from my military service, but maybe it's my father's, or his father's, maybe it's an insidious family legacy that was just never noticed. This is because having both parents and grandparents with major depressive disorder (MDD) was associated with higher risk of MDD for grandchildren, which could help identify those who may benefit from early intervention.

... Read more »

Myrna M. Weissman, PhD, Obianuju O. Berry, MD, MPH, Virginia Warner, DrPH, Marc J. Gameroff, PhD, Jamie Skipper, MS, Ardesheer Talati, PhD, Daniel J. Pilowsky, MD, MPH, & Priya Wickramaratne, PhD. (2016) A 30-Year Study of 3 Generations at High Risk and Low Risk for Depression. JAMA Psychiatry . info:/10.1001/jamapsychiatry.2016.1586

  • August 10, 2016
  • 10:00 AM
  • 341 views

Dog Bite Strength: It's Not What You Think

by CAPB in Companion Animal Psychology Blog

Scientists tracked down the evidence for a common statement about bite strength in dogs – and found it lacking.Have you ever read comments about the strength of a dog’s jaw when it bites? These statements are often made in relation to certain types of dog, like pit bulls. Maybe some people take it as fact. But what if it’s not true?A recent paper by Dr. Gary Patronek (Cummings School of Veterinary Medicine, Tufts University) et al traced citations in the literature and went back to the ori........ Read more »

  • August 10, 2016
  • 08:55 AM
  • 294 views

Gimme Some Dihydrogen Monoxide

by Mark Lasbury in As Many Exceptions As Rules

One cannot over estimate the ways that water affects life on Earth. Beyond its chemical properties, some animals have evolved to substitute water for a rigid skeleton. Hydrostatic skeletons can be used for support, but also as water vascular systems that provide pressure for vascular transport and respiration. A recent review by William H. Kier sheds light on the interactions of different fibers and tissues in water based skeletons. Yet some plants can withstand a loss of 60% of their water, whe........ Read more »

Kier, W. (2012) The diversity of hydrostatic skeletons. Journal of Experimental Biology, 215(8), 1247-1257. DOI: 10.1242/jeb.056549  

  • August 10, 2016
  • 04:30 AM
  • 322 views

Hands off the Hands-free Ultrasound If You Are Looking for Deep Heating Effects

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

A hands-free ultrasound unit at 1 MHz failed to increase the temperature deep in the gastrocnemius after 10 minutes.... Read more »

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