The very word ‘willpower’ implies a metaphor: that actions (and inhibition of actions) are a matter of conscious will and that they require the use of a resource or source of power. What powers the will is willpower. This is a sort of folk psychology – it takes a special sort of effort to have […]... Read more »
Brass M, Lynn MT, Demanet J, & Rigoni D. (2013) Imaging volition: what the brain can tell us about the will. Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale, 229(3), 301-12. PMID: 23515626
Foundation Medicine published a wonderful paper in Nature Biotechnology last month. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing describes their approach to personalised cancer genomics.Foundation Medicines "Foundation 1" test allows NGS analysis of 287 genes from FFPE samples for SNPs, InDels, CNA's and fusions. They describe the design and testing of this panel along with results from over 2000 clinical samples, finding "........ Read more »
Frampton GM, Fichtenholtz A, Otto GA, Wang K, Downing SR, He J, Schnall-Levin M, White J, Sanford EM, An P.... (2013) Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nature biotechnology, 31(11), 1023-31. PMID: 24142049
Neuroimaging techniques have been widely used to study the brain as well as for clinical applications. New developments direct neuroscience towards more practical applications of neuroimaging, that go beyond research or health care, explaining pedophelial behaviour, improving movie making and more.... Read more »
Ansari, D., De Smedt, B. . (2012) Neuroeducation- A critical overview of an emerging field. Neuroethics. DOI: 10.1007/s12152-011-9119-3
Ariely D, & Berns GS. (2010) Neuromarketing: the hope and hype of neuroimaging in business. Nature reviews. Neuroscience, 11(4), 284-92. PMID: 20197790
by amikulak in Daily Observations
It’s that time of year again – the time to gather with family and friends, to celebrate the passing of another year…to spend hours in a car dealing with pent-up […]... Read more »
Wickens, C.M., Mann, R.E., & Wiesenthal, D.L. (2013) Addressing Driver Aggression: Contributions From Psychological Science. Current Directions in Psychological Science, 22(5), 386-391. DOI: 10.1177/0963721413486986
Plastic Dinner. Photo by Alex Bond.
Imagine carrying around several kilos (or
pounds) of plastic in your stomach, unable to rid yourself of it, and gradually
adding pieces day by day. This is
what many marine animals go through every day. Millions of pieces of plastic enter the world’s oceans each
day, and once it’s there, it doesn’t go away. Instead, it breaks into smaller and ... Read more »
Bond, A.L., J.F. Provencher, R.D. Elliot, P.C. Ryan, S. Rowe, I.L. Jones, & G.J. Robertson S.I. Wilhelm. (2013) Ingestion of plastic marine debris by Common and Thick-billed Murres in the northwestern Atlantic from 1985 to 2012. Marine Pollution Bulletin. DOI: 10.1016/j.marpolbul.2013.10.005
Bond AL, & Lavers JL. (2013) Effectiveness of emetics to study plastic ingestion by Leach's Storm-petrels (Oceanodroma leucorhoa). Marine pollution bulletin, 70(1-2), 171-5. PMID: 23507234
Avery-Gomm S, O'Hara PD, Kleine L, Bowes V, Wilson LK, & Barry KL. (2012) Northern fulmars as biological monitors of trends of plastic pollution in the eastern North Pacific. Marine pollution bulletin, 64(9), 1776-81. PMID: 22738464
So you need to ask someone to do something and that “something” lies in the morally murky or ambiguous realm. We won’t offer examples of what that favor may be, but you know what we mean. You may wonder when is best to ask. Right after you’ve begun the day (and they’ve had ample coffee)? […]
Leading our unethical leaders: Behaving as we want our jurors to behave
Which is the more moral negotiator? The male or the female?
What’s a moral issue for us these days?
........ Read more »
Kouchaki M, & Smith IH. (2013) The Morning Morality Effect: The Influence of Time of Day on Unethical Behavior. Psychological Science. PMID: 24166855
by Moselio Schaechter in Small Things Considered
By Merry Youle
We live in a world run by microbes, the vast majority of which we have yet to identify or name. We can only refer to them collectively as the microbial dark matter (MDM). However you define a prokaryotic species, and however you tally them once identified, there is a huge gap between the 12,000 or so validly-named species and the total number on our planet, currently estimated to be in the millions. The only evidence we have for the existence of that uncultured mob is either a sm........ Read more »
Rinke C, Schwientek P, Sczyrba A, Ivanova NN, Anderson IJ, Cheng JF, Darling A, Malfatti S, Swan BK, Gies EA.... (2013) Insights into the phylogeny and coding potential of microbial dark matter. Nature, 499(7459), 431-7. PMID: 23851394
New research suggests that formal leaders with a strong sense of personal power have a negative impact on the performance of their team. The work by Leigh Tost and colleagues outlines how feeling powerful leads to a sense of entitlement within group discussions that can crowd out other voices and lead to less valuable information-sharing. This happens only when the powerful-feeling person has a formal leadership role; if they don’t, other group members don't allow the domination and therefore ........ Read more »
Leigh Plunkett Tost, Francesca Gino, & Richard P. Larrick. (2013) When Power Makes Others Speechless: The Negative Impact of Leader Power On Team Performance. Academy of Management Journal,, 56(5), 1465-1486. DOI: 10.5465/amj.2011.0180
The faster people do things, the more mistakes they make. Also known as the speed-accuracy trade-off, this rule is considered by many fundamental to human behaviour. Not so, according to sports psychologist James Bell and his colleagues. They've authored a new paper that suggests people who score higher on the personality trait of neuroticism make more accurate judgments the faster they respond.One hundred and ninety-six teenage male cricketers, all members of regional academies, took part in th........ Read more »
James J. Bella, Lauren Mawn, & Rosemary Poynor. (2013) Haste makes waste, but not for all: The speed-accuracy trade-off does not apply to neurotics. Psychology of Sport and Exercise. DOI: 10.1016/j.psychsport.2013.07.001
One of the important strategies in the treatment of cancer is inhibition of DNA methylation that is frequently found in cancer cells.
Zebularine (Zeb) is a novel DNA methyltransferase (DNMT) inhibitor, i.e. it inhibits DNA methylation. Researchers are of opinion that targeting GRP78/p62 and stemness by Zeb could be a potential therapeutic strategy to treat colorectal cancer (CRC).
p53 is a tumor suppressor protein that stimulates endoplasmic reticulum (ER) stress but the mechanism behind t........ Read more »
Pei-Ming Yang et al. (2013) Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress. Scientific Reports. DOI: 10.1038/srep03219
Pseudoscience seems to be everywhere: from anti-vaccine activism and HIV/AIDS denialism to postmodern pseudomathematics and quantum quackery. It would appear that no area goes unharmed by the enormous reach of pseudoscience. It has even infiltrated law enforcement where it injects pseudoscientific notions such as hypnosis and graphology, prevent safeguards against error in interrogations and fingerprint analysis or making it more difficult to remove practices that are not supported by the eviden........ Read more »
Scott O. Lilienfeld, & Kristin Landfield. (2008) Science and Pseudoscience in Law Enforcement: A User-Friendly Primer. Criminal Justice and Behavior, 35(10), 1215-1230. DOI: 10.1177/0093854808321526
A study shows for the first time that X-ray lasers can be used to generate a complete 3-D model of a protein without any prior knowledge of its structure.
An international team of researchers working at the Department of Energy’s (DOE) SLAC National Accelerator Laboratory produced from scratch an accurate model of lysozyme, a well-studied enzyme found in egg whites, using the Linac Coherent Light Source (LCLS) X-ray laser and sophisticated computer analysis tools.... Read more »
Thomas R. M. Barends,, Lutz Foucar,, Sabine Botha,, R. Bruce Doak,, Robert L. Shoeman,, Karol Nass,, Jason E. Koglin,, Garth J. Williams,, Sébastien Boutet,, Marc Messerschmidt,.... (2013) De novo protein crystal structure determination from X-ray free-electron laser data. Nature . DOI: 10.1038/nature12773
Scanning electron micrograph of a human T cellThe lab of Avinash Bhandoola, PhD, professor of Pathology and Laboratory Medicine at Penn Medicine, has been studying the origins of T cells for a long time now. One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development. T cells are immune cells that are made in the thymus, a small organ situated under the breastbone near the heart.However, T cells, like all b........ Read more »
De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, Delong JH, Zlotoff DA, Sultana DA, Pear WS, & Bhandoola A. (2013) T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1. Nature immunology, 14(12), 1277-84. PMID: 24185616
I first heard about this while I was watching Grey’s Anatomy. Meredith was trying to print a 3D model of a liver, and I thought “That’s cool, but it will never happen.” As it turns out, I was wrong – it’s already happening.... Read more »
Lee VK, Singh G, Trasatti JP, Bjornsson C, Tran TN, Xu G, Yoo SS, Dai G, & Karande P. (2013) Design and Fabrication of Human Skin by 3D Bioprinting. Tissue engineering. Part C, Methods. PMID: 24188635
If anything else, the recent discussions on the principles of RDoC - Research Domain Criteria (see here) - being applied to psychiatry have prompted many to question whether our current diagnostic labels are actually fit for purpose when it comes to answering the big research questions of how and why.Bottoms up? @ Wikipedia RDoC, for those of you who might not know, is described by the US National Institute of Mental Health (NIMH) as an attempt to: "define basic dimensions of functioni........ Read more »
Unwin LM, Maybery MT, Wray JA, Whitehouse AJ. (2013) A "bottom-up" approach to aetiological research in autism spectrum disorders. Front Hum Neurosci. DOI: 10.3389/fnhum.2013.00606
Hey Julie,it's not every week I get to issue an invitation to the entire world, but that's exactly what I'm doing today! MiaStudents invited to compete in global dog poo competition:Poo Power! Global Challenge launches Monday 25 November 2013Students and classes will be pitched against each other to see who can identify the most and largest dog waste 'hotspots' in their local neighbourhood in the 'Poo Power! Global Challenge'. Participants use a GPS-enabled iPhone to download the free Poo P........ Read more »
Okoroigwe E.C., Ibeto C.N., & Okpara C.G. (2010) Comparative Study of the Potential of Dog Waste for Biogas Production. Trends in Applied Sciences Research, 5(1), 71-77. DOI: 10.3923/tasr.2010.71.77
Nemiroff Leah. (2007) Design, Testing and Implementation of a Large-Scale Urban Dog Waste Composting Program. Compost Science , 15(4), 237-242. info:other/http://montrealndgdogrun.org/image/downloads/compost studies.pdf
When I was young, the one superpower I craved above all was perfect memory. I’d picture my eyes as camcorder lenses, recording everything I read, saw and experienced into the Kodak film that was my brain. Anytime I wanted to re-experience something, I’d simply hit a mental “play” button and BAM! The video of my […]... Read more »
Patihis L, Frenda SJ, Leport AK, Petersen N, Nichols RM, Stark CE, McGaugh JL, & Loftus EF. (2013) False memories in highly superior autobiographical memory individuals. Proceedings of the National Academy of Sciences of the United States of America. PMID: 24248358
Researchers at Scripps Institution of Oceanography at UC San Diego have developed a method for greatly enhancing biofuel production in tiny marine algae by increasing lipid output without sacrificing growth.... Read more »
Trentacoste E.M., Shrestha R.P., Smith S.R., Glé C., Hartmann A.C., Hildebrand M., & Gerwick W.H. (2013) Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth. Proceedings of the National Academy of Sciences of the United States of America. PMID: 24248374
Researchers have found that females have better ability to recognize hostile angry movement of males while males have better ability to recognize happy walking of females.
In the present study, researchers presented human locomotion with various emotional expressions, i.e. neutral, happiness and anger, to fifty three healthy female and male adult observers in the age range of 22-25 years.
Researchers found that emotions portraye........ Read more »
The members of the Tissue Engineering Team at the Dept. of Histology at the University of Granada.Yesterday, researchers at the University of Granada announced an important scientific breakthrough, that may aid in the immediate use of artificially-grown skin for major burn patients, since the skin could be stored in tissue banks and made available when needed.One of the problems major burn victims face is that, using the current protocols for artificial skin, they need to wait several weeks in ........ Read more »
Garzón I, Miyake J, González-Andrades M, Carmona R, Carda C, Sánchez-Quevedo Mdel C, Campos A, & Alaminos M. (2013) Wharton's jelly stem cells: a novel cell source for oral mucosa and skin epithelia regeneration. Stem cells translational medicine, 2(8), 625-32. PMID: 23817131
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