Post List

  • December 9, 2010
  • 12:37 PM
  • 1,340 views

New Mouse Model for Muscular Dystrophy

by Sanford- Burnham in Beaker

Roughly 50,000 people in the United States are affected by some type of muscular dystrophy, a condition characterized by debilitating muscle loss. Duchenne muscular dystrophy (DMD), the most common form of the disease, is caused by a mutation in the dystrophin gene. Without dystrophin, the interior muscle fiber frame can’t properly connect to the surrounding [...]... Read more »

Sacco A, Mourkioti F, Tran R, Choi J, Llewellyn M, Kraft P, Shkreli M, Delp S, Pomerantz JH, Artandi SE.... (2010) Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice. Cell. info:/10.1016/j.cell.2010.11.039

  • December 9, 2010
  • 12:16 PM
  • 1,084 views

The neuroscientific study of hallucinogens

by Bradley Voytek in Oscillatory Thoughts

Recently, an important and landmark paper was published in PLoS ONE (hooray open access!) titled, "Investigating the Mechanisms of Hallucinogen-Induced Visions Using 3,4-Methylenedioxyamphetamine (MDA): A Randomized Controlled Trial in Humans". It sounds daunting, but trust me, it's a very cool, approachable study.Now, in the spirit of full-disclosure, the lead author Dr. Matthew Baggott (hereafter referred to as "Matt"), is a friend of mine from grad school and he's been kind enough to grant me........ Read more »

Voytek B, Berman SM, Hassid BD, Simon SL, Mandelkern MA, Brody AL, Monterosso J, Ling W, & London ED. (2005) Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusers. Synapse (New York, N.Y.), 57(2), 113-5. PMID: 15906384  

Berman SM, Voytek B, Mandelkern MA, Hassid BD, Isaacson A, Monterosso J, Miotto K, Ling W, & London ED. (2008) Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse. Molecular psychiatry, 13(9), 897-908. PMID: 17938635  

  • December 9, 2010
  • 11:59 AM
  • 1,035 views

Risk of lung cancer after treatment for breast cancer

by Sally Church in Pharma Strategy Blog

There was an interesting paper published recently in The Lancet Oncology, which looked at the increased risk of developing lung cancer after women had experienced prior breast cancer (see ref below).  Over the years, there has been much debate about … Continue reading →... Read more »

Lorigan, P., Califano, R., Faivre-Finn, C., Howell, A., & Thatcher, N. (2010) Lung cancer after treatment for breast cancer. The Lancet Oncology, 11(12), 1184-1192. DOI: 10.1016/S1470-2045(10)70056-5  

  • December 9, 2010
  • 10:45 AM
  • 734 views

The snowshoe hare-coyote-Dall's sheep cycle?

by TwoYaks in Gene Flow

When we teach our students predator-prey relationships, we tend to tell them a very basic story that have come from a few very good studies. It's not that all we have are simple models, but but we like to build up the basics before we dive into the complexities. Because when you get down to the complexities, a lot of counter-intuitive things happen which don't follow "common-sense" relationships.... Read more »

  • December 9, 2010
  • 09:19 AM
  • 771 views

Foiling Fungal Forgery with French Fingerprinting Forensics

by avi_wener in The European Biotechnologist

The black truffle is a fungus that grows almost exclusively in Europe and has been termed “the diamond of the kitchen” by 18th-century French gastronome Brillat-Savarin (source: Wikipedia). Production has considerably diminished in the past century, and in accordance with the law of supply and demand, the price of the truffle has skyrocketed to approximately [...]... Read more »

Martin F, Kohler A, Murat C, Balestrini R, Coutinho PM, Jaillon O, Montanini B, Morin E, Noel B, Percudani R.... (2010) Périgord black truffle genome uncovers evolutionary origins and mechanisms of symbiosis. Nature, 464(7291), 1033-8. PMID: 20348908  

  • December 9, 2010
  • 07:30 AM
  • 1,203 views

Good Idea, Bad Execution: Dosing Errors, A Preventable Harm

by Scott in Science-Based Pharmacy

Crossposted at Science-Based Medicine, today’s post expands on a prior SBP post. Our desire to practice in a science-based way can face many hurdles, and can even be thwarted at the last possible moment – in the form of dosing errors. The workup may have been comprehensive, the diagnosis could be correct, the most clinically [...]... Read more »

Yin HS, Mendelsohn AL, Wolf MS, Parker RM, Fierman A, van Schaick L, Bazan IS, Kline MD, & Dreyer BP. (2010) Parents' medication administration errors: role of dosing instruments and health literacy. Archives of pediatrics , 164(2), 181-6. PMID: 20124148  

  • December 9, 2010
  • 07:00 AM
  • 678 views

Dying to Work Overtime

by Shaheen Lakhan in Brain Blogger

President Ronald Reagan once joked that hard work never killed anyone, but why take the chance? According to a new study, he may have been correct in avoiding burning the proverbial midnight oil. A study published in the European Heart Journal reports that working overtime is an independent risk factor for incident cardiovascular disease. Researchers [...]... Read more »

Lallukka T, Martikainen P, Reunanen A, Roos E, Sarlio-Lähteenkorva S, & Lahelma E. (2006) Associations between working conditions and angina pectoris symptoms among employed women. Psychosomatic medicine, 68(2), 348-54. PMID: 16554403  

Lallukka T, Sarlio-Lähteenkorva S, Roos E, Laaksonen M, Rahkonen O, & Lahelma E. (2004) Working conditions and health behaviours among employed women and men: the Helsinki Health Study. Preventive medicine, 38(1), 48-56. PMID: 14672641  

Schulte PA, Wagner GR, Ostry A, Blanciforti LA, Cutlip RG, Krajnak KM, Luster M, Munson AE, O'Callaghan JP, Parks CG.... (2007) Work, obesity, and occupational safety and health. American journal of public health, 97(3), 428-36. PMID: 17267711  

Steptoe A, Cropley M, & Joekes K. (1999) Job strain, blood pressure and response to uncontrollable stress. Journal of hypertension, 17(2), 193-200. PMID: 10067788  

Virtanen M, Ferrie JE, Singh-Manoux A, Shipley MJ, Vahtera J, Marmot MG, & Kivimäki M. (2010) Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study. European heart journal, 31(14), 1737-44. PMID: 20460389  

  • December 9, 2010
  • 07:00 AM
  • 1,517 views

Good Idea, Bad Execution: Dosing Errors, A Preventable Harm

by Scott Gavura in Science-Based Medicine

We spend a lot time at SBM discussing different elements of the art and science of medicine, and how we believe that practice can be improve. Yet our science-based intentions can be thwarted at the last possible moment – in the form of dosing errors. The workup may have been comprehensive, the diagnosis could be [...]... Read more »

Yin HS, Mendelsohn AL, Wolf MS, Parker RM, Fierman A, van Schaick L, Bazan IS, Kline MD, & Dreyer BP. (2010) Parents' medication administration errors: role of dosing instruments and health literacy. Archives of pediatrics , 164(2), 181-6. PMID: 20124148  

  • December 9, 2010
  • 07:00 AM
  • 1,350 views

Sedentary Physiology Part 4 – How Does Sitting Increase Health Risk?

by Travis Saunders, MSc, CEP in Obesity Panacea


http://www.flickr.com/photos/phrenzee/ / CC BY 2.0

Welcome to our 5-part series delving into the fascinating research being performed in the emerging field of sedentary physiology.  In Part 1 we discussed the basics of sedentary physiology, in Part 2 we discussed the relationship between total sedentary time and negative health outcomes, and in Part 3 we examined how interruptions in sedentary time may be protective health benefits.  Today we look at the mechanisms underlying these relat........ Read more »

  • December 9, 2010
  • 07:00 AM
  • 1,100 views

December 9, 2010

by Erin Campbell in HighMag Blog

Some of the most striking and informative images aren’t of cells or organisms, but are computer-generated representations of what is going on in cells or organisms. These computer-generated images come from the use of two-photon microscopy, a powerful technique that allows for imaging of tissue that’s buried deep in a living organism.... Read more »

  • December 9, 2010
  • 06:41 AM
  • 618 views

Nutritional Stuff, Protein and Vegetarianism

by ABK in Environment and Health

I don't want to get into why I find the whole paleo diet thing so aggravating.  I do find some of the assumptions funny and a little naive, but I think its mainly the hype and messianic tone that make it hard for me to listen too.  However, late at night, when I can't sleep, I sometimes look at articles dealing with nutrition and here are two that piqued my curiosity.One is that high protein maternal diets may predispose infants (at least rats anyway) to greater risk of obesity later i........ Read more »

  • December 9, 2010
  • 05:51 AM
  • 975 views

Inter-speaker variation and detection of invariant structure

by Sean Roberts in A Replicated Typo 2.0

Results of a web-experiment. Gomez (2002) shows that increased variation in adjacent dependencies can cause learners to pick up on long-distance dependencies. I hypothesise that the variation in input from multiple speakers gives better cues to more abstract structures than input from one speaker alone.... Read more »

Gómez RL. (2002) Variability and detection of invariant structure. Psychological science : a journal of the American Psychological Society / APS, 13(5), 431-6. PMID: 12219809  

  • December 9, 2010
  • 05:42 AM
  • 1,139 views

Eye on the ball

by Wellcome Trust in Wellcome Trust Blog

When studying eye movement, it is easy to imagine someone sitting in a darkened room, following a dot around a computer screen. New research suggests that the future of this research may require a shifting of the goal posts. Dr Christina Howard and colleagues from the Department of Experimental Psychology, University of Bristol describe a [...]... Read more »

Howard CJ, Troscianko T, & Gilchrist ID. (2010) Eye-response lags during a continuous monitoring task. Psychonomic bulletin , 17(5), 710-7. PMID: 21037171  

  • December 9, 2010
  • 05:30 AM
  • 965 views

Nonshocker! Preschool kids think thinner is better.

by Yoni Freedhoff in Weighty Matters

I'm not surprised, are you?A study out of the journal Sex Roles took a look at preschoolers' attitudes towards obesity by means of Candy Land and Chutes and Ladders. They took 55 girls aged 3-5 and had them choose which character they wanted to be. 69% chose the thinnest, 20% the average and 11% the largest. Moreover when asked to swap thinnest for largest, 63% refused.One of the study's authors apparently was surprised by the findings and she was quoted in the Montreal Gazette stating, "I was........ Read more »

  • December 9, 2010
  • 05:14 AM
  • 921 views

Do political scandals really distract us from important issues?

by BPS Research Digest in BPS Research Digest

Barely a day goes by without some political scandal or other splashed across the papers. Critics argue this obsession with tittle-tattle distracts the electorate from more important policy issues. '...a fiercely independent media is the guarantor of democracy,' Will Hutton wrote in 2000, before warning that the British media's obsession with scandal 'paradoxically, may be beginning to endanger it [democracy]'.

A new study by Beth Miller at the University of Missouri-Kansas City challenges the a........ Read more »

  • December 9, 2010
  • 05:00 AM
  • 913 views

A few facts about asbestos

by sciencebase in Sciencebase Science Blog

Today, medical journal The Lancet has publicly criticised the Canadian government for its attitude towards asbestos, saying that although Canada will not expose its own citizens to asbestos, it will continue exporting the deadly substance to developing nations [Canada accused of hypocrisy, Lancet]. A few facts about asbestos All forms of asbestos are proven human [...]A few facts about asbestos is a post from: Sciencebase Science Blog
... Read more »

Collegium Ramazzini. (2010) Asbestos is still with us: repeat call for a universal ban. International Journal of Environment and Health, 4(4), 380-388. info:/

  • December 9, 2010
  • 05:00 AM
  • 272 views

Obstacles to RNAi drug therapies

by Linda in Oz Blog No. 159

A small RNA (siRNA or miRNA) is the "magic bullet" in biotechnology. It's easy to manufacture, it's on target and has high "kill" rates. According to an Industry rep, it currently takes 2 billion USD to launch a new chemical product and the revenue comes back in negative. So companies actually wind up in a deficit when they put out a newly developed drug. However, the "magic bullet" is going to change all of that around. One company alone invested 1.2 bill........ Read more »

  • December 9, 2010
  • 02:00 AM
  • 475 views

Bed rest can harm, instead of help, in pregnancy complications

by SAGE Insight in SAGE Insight

Antepartum Bed Rest for Pregnancy Complications: Efficacy and Safety for Preventing Preterm Birth From Biological Research for Nursing  This article reveals that bed rest may not be the best option for preventing preterm labor and may even cause harm to the mother and baby. Bed rest is prescribed for up to 1 million women in [...]... Read more »

  • December 8, 2010
  • 06:12 PM
  • 892 views

Falsehoods associated with the arsenic-thriving bacteria story: What it is and what it isn't

by Daniel in Ego sum Daniel

>> My previous post was more of a summary of what the reporting of the "NASA arsenic-thriving bacteria" story looked like from my perspective in the wake of the massive Internet onslaught of information. In this post I want to talk about how the style of communication that drove this story has lead to the dissemination of falsehoods or misconceptions that hinder a proper understanding of biology in general, regardless of the validity of the actual findings.

The aftermath
Last week I conc........ Read more »

Wolfe-Simon, F., Switzer Blum, J., Kulp, T.R., Gordon, G.W., Hoeft, S.E., Pett-Ridge, J., Stolz, J.F., Webb, S.M., Weber, P.K., Davies, P.C.W., Anbar, A.D., Oremland, R.S. (2010) A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus. Science. info:/10.1126/science.1197258

  • December 8, 2010
  • 05:19 PM
  • 1,309 views

Daily Aspirin May Reduce Risk of Cancer Death

by Dan Bailey in Smells Like Science

Aspirin knows how to multitask. It was originally developed more than a century ago as a pain reliever, but it was soon discovered that it also reduces fever and fights inflammation. In the last 30 years it was found that a daily low dose of aspirin reduces the risk of heart attacks and strokes. And now a new study suggests that aspirin taken over an extended time period reduces the risk of death from a variety of solid tumor cancers, including colorectal, lung, esophageal, and gastrointestinal ........ Read more »

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