Post List

  • September 17, 2011
  • 05:57 AM

How dangerous are viral quasispecies?

by Connor Bamford in The Rule of 6ix

Chikungunya virus particles emerging from an infected cell - is genetic diversity important to this virus?


   At around 1 mutation per 1,000 - 100,000 nucleotides per round of replication, RNA viruses have the highest mutation rate of anything seen in nature to date. During an infection of a single cell, thousands of new genomes are produced that will go on to make new virus particles; each genome will differ from another at most maybe 10 nucleotides (given an avera........ Read more »

Coffey, L., Beeharry, Y., Borderia, A., Blanc, H., & Vignuzzi, M. (2011) Arbovirus high fidelity variant loses fitness in mosquitoes and mice. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1111650108  

  • September 17, 2011
  • 02:29 AM

How long as the Atacama been dry?

by Lab Lemming in Lounge of the Lab Lemming

“I am flying home from Europe in late August with nothing but a notebook and the 2011 Goldschmidt conference Geology giveaway issue to keep me occupied. Using the old-fashioned method of reading and writing on paper, I will blog my way through the compilation of highlighted geochemistry papers as time allows. These will then be posted via time delay to keep the blog moving while preventing ... Read more »

  • September 16, 2011
  • 08:53 PM

How many pixels make an object? Like, 30

by Patrick Mineault in xcorr

There’s a neat paper on the psychophysics of scene and object recognition in super-low resolution scenarios in Visual Neuroscience by A. Torralba (2009). The author sought to answer a rather interesting question: what image resolution is needed to support scene and object recognition? He took images from databases and created several different versions of them, [...]... Read more »

Torralba A. (2009) How many pixels make an image?. Visual neuroscience, 26(1), 123-31. PMID: 19216820  

  • September 16, 2011
  • 06:23 PM

Predictors of PTSD in children and adults

by Eva Alisic in Trauma Recovery

We know that traumatic events occur quite often. We also know that most people are resilient, even though many survivors experience some distress in the direct aftermath of an event. Only a minority will develop longer-term stress symptoms. What are their characteristics? Who is ‘at risk’ after trauma? ... Read more »

Alisic, E., Jongmans, M., van Wesel, F., & Kleber, R. (2011) Building child trauma theory from longitudinal studies: A meta-analysis. Clinical Psychology Review, 31(5), 736-747. DOI: 10.1016/j.cpr.2011.03.001  

  • September 16, 2011
  • 05:48 PM

Thank you Mario! But your methods are in another field!

by Bradley Voytek in Oscillatory Thoughts

My love for video games is no secret. I just finished Mass Effect 2 and started Dragon Age 2 (I'm a sucker for Bioware RGPs).One of the first true peer-review papers I remember reading was Green & Bavelier's 2003 Nature paper "Action video game modifies visual selective attention". In that study the authors performed a series of experiments showing that people who had a lot of experience playing "action video games" performed better than non-video game players on a variety of attention tasks. Pa........ Read more »

Owen, A., Hampshire, A., Grahn, J., Stenton, R., Dajani, S., Burns, A., Howard, R., & Ballard, C. (2010) Putting brain training to the test. Nature, 465(7299), 775-778. DOI: 10.1038/nature09042  

  • September 16, 2011
  • 03:59 PM

Is it time for a conceptual revolution in neuroscience?

by davejhayes in neurosphere

A recent article by Russell Poldrack and colleagues begins with an apt quote from Rutherford D. Rogers, the former Yale University Librarian:

“We’re drowning in information and starving for knowledge”

They chose this quote to reflect what some brain researchers (myself included) might call a major roadblock in contemporary neuroscience...... Read more »

  • September 16, 2011
  • 03:15 PM

Evolved for Arrogance

by Elizabeth Preston in Inkfish

Why does nature allow us to lie to ourselves? Humans are consistently and bafflingly overconfident. We consider ourselves more skilled, more in control, and less vulnerable to danger than we really are. You might expect evolution to have weeded out the brawl-starters and the X-Gamers from the gene pool and left our species with a firmer grasp of our own abilities. Yet our arrogance persists.

In a new paper published in Nature, two political scientists say they've figured out the reason. There's........ Read more »

Johnson, D., & Fowler, J. (2011) The evolution of overconfidence. Nature, 477(7364), 317-320. DOI: 10.1038/nature10384  

  • September 16, 2011
  • 02:18 PM

Observations: Why do women cry? Obviously, it’s so they don’t get laid.

by Christie Wilcox in Science Sushi

This week, a paper came out looking at testosterone levels in fathers. A whirlwind of poor journalism followed, which was beautifully smacked down by William Saletan over at Slate (aslo: see this great post on the topic by our very own Kate Clancy). But it reminded me of a similar kerfluffle that occurred this past [...]

... Read more »

Gelstein, S., Yeshurun, Y., Rozenkrantz, L., Shushan, S., Frumin, I., Roth, Y., & Sobel, N. (2011) Human Tears Contain a Chemosignal. Science. DOI: 10.1126/science.1198331  

Haga S, Hattori T, Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, & Touhara K. (2010) The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor. Nature, 466(7302), 118-22. PMID: 20596023  

Storey AE, Walsh CJ, Quinton RL, & Wynne-Edwards KE. (2000) Hormonal correlates of paternal responsiveness in new and expectant fathers. Evolution and human behavior : official journal of the Human Behavior and Evolution Society, 21(2), 79-95. PMID: 10785345  

Zak, P., Kurzban, R., Ahmadi, S., Swerdloff, R., Park, J., Efremidze, L., Redwine, K., Morgan, K., & Matzner, W. (2009) Testosterone Administration Decreases Generosity in the Ultimatum Game. PLoS ONE, 4(12). DOI: 10.1371/journal.pone.0008330  

  • September 16, 2011
  • 11:32 AM

Whole-genome sequencing and clinical annotation

by Daniel Koboldt in Massgenomics

Next-generation sequencing has immense transformative potential for medicine in the coming decade. Rapid, economical whole-genome sequencing can provide a wealth of information useful for diagnosis, treatment, and even prevention of disease. Very soon (if not already), generating whole-genome sequencing data will be routine. The challenges will lie in accurate variant calling, phasing, annotation, and clinical [...]... Read more »

Frederick E. Dewey, Rong Chen, Sergio P. Cordero, Kelly E. Ormond, Colleen Caleshu, Konrad J. Karczewski, Michelle Whirl-Carrillo, Matthew T. Wheeler, Joel T. Dudley, Jake K. Byrnes, Omar E. Cornejo, Joshua W. Knowles, Mark Woon, Katrin Sangkuhl, Li Gong,, Madeleine P. Ball, Alexander W. Zaranek, Heidi L. Rehm, George M. Church, John S. West, Carlos D. Bustamante, Michael Snyder, Russ B. Altman, Teri E. Klein.... (2011) Phased whole genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genetics, 7(9). info:/

  • September 16, 2011
  • 10:03 AM

Tuberous sclerosis complex and autophagy

by Joana Guedes in BHD Research Blog

Tuberous sclerosis complex (TSC) is a multi-system disorder caused by mutations in the TSC1 or TSC2 genes. As illustrated in the signalling diagram on, TSC1/2 plays an important role in regulating the mammalian target of rapamycin complex 1 (mTORC1), which is involved … Continue reading →... Read more »

Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C.... (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell, 137(6), 1062-75. PMID: 19524509  

Parkhitko A, Myachina F, Morrison TA, Hindi KM, Auricchio N, Karbowniczek M, Wu JJ, Finkel T, Kwiatkowski DJ, Yu JJ.... (2011) Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent. Proceedings of the National Academy of Sciences of the United States of America, 108(30), 12455-60. PMID: 21746920  

  • September 16, 2011
  • 07:58 AM

Can we get away with using lo-fi assessment to recruit advanced positions?

by Alex Fradera in BPS Occupational Digest

In recruitment, the promise of comparable results for less effort is understandably tempting. It's offered by the offsetting of costly assessments with alternative measures that use pencils, screens and standardised questions instead of expert assessors. However, as some sources suggest a bad hire can cost twice or more that position's annual salary, the stakes are high. A new study kicks some assessment tyres to see whether that bargain is actually a banger.Researchers Filip Lievens and Fiona P........ Read more »

  • September 16, 2011
  • 07:02 AM

Tethered, multi-tasking, or just life?

by Rita Handrich in The Jury Room

When I was in graduate school, I carried a beeper for my job. I hated that thing. I felt like I was on a tether and constantly available to everyone. Even when it didn’t alert me to call someone, I was constantly expecting it would. It was horrible. Now, when I consider that angst-filled attitude, [...]

Related posts:Simple Workaholic Persuasion: How to really take a vacation
Between Coddling and Contempt: Managing and Mentoring Millennials
... Read more »

  • September 16, 2011
  • 07:00 AM

Being a fish out of water changes you

by Zen Faulkes in NeuroDojo

It might be tricky to keep mangrove rivulus in your typical aquarium. Mangrove rivulus are rather found of jumping out of water – and staying there.

Being out of water is a rather different place from being in the water, and so this fish obviously have some evolutionary adaptations that allow it to pull off this stunt. But a new paper asks a different, possibly more subtle: do mangrove rivulus adapt to being in or out of water in the short term?

ResearchBlogging.orgMangrove rivulu........ Read more »

  • September 16, 2011
  • 12:00 AM

The Big Picture : 5-hmC Content is Differentiation Dependent in Adult Tissues

by Nicole in E3 Engaging Epigenetics Experts

Interview with Dr.Yegnasubramanian on 5-hmC localization paper.... Read more »

  • September 15, 2011
  • 09:39 PM

Nunavut’s Big, Bad Fossil Fish

by Laelaps in Laelaps

Have you ever had a bad neighbor? The kind that blasts heavy metal at 3AM, “exercises” their dog on your lawn, and is just an all-around jerk? Well, bad as they were, chances are that you didn’t have to worry about them eating you (unless they were into some REALLY weird stuff). Our ancient, 375 [...]... Read more »

  • September 15, 2011
  • 12:31 PM

The future of cognitive neuroscience

by Jon Simons in Brain, n. An apparatus with which we think that we think

I have previously written about how I think that cognitive neuroscience as a scientific discipline (and I know that this is not a universally held view) has largely moved on from publishing studies demonstrating the neural correlates of “x”, where x might be behaviours as diverse as maternal love, urinating, or thinking about god.  There are still a few of these sorts of studies published each year, and because the public are, it seems, fascinated by stories about blobs on brains, the m........ Read more »

  • September 15, 2011
  • 12:22 PM

The Fungal Apocalypse, Permo-Triassic Edition

by Jennifer Frazer in The Artful Amoeba

There is something curious about the sedimentary rocks laid down around the world 250 million years ago, at the height of Earth’s greatest extinction: they are often riddled with filaments, and no one is sure what they are. Nothing like them has been found in rocks before or since. What seems apparent, and what everyone [...]... Read more »

  • September 15, 2011
  • 12:22 PM

All you need is love... and the right alleles

by EE Giorgi in CHIMERAS

It's been called the "love hormone" because studies have shown that it is released during labor and breastfeeding. Children soothed by their mothers produce it, and, apparently, it has a role in easing social interactions. Oxytocin is a hormone secreted by the pituitary gland. It is a neurotransmitter, which basically means that it helps send signals from the brain to the receiving cells.OXTR is the oxytocin gene receptor, in other words, this gene codes the protein that sits on t........ Read more »

Saphire-Bernstein, S., Way, B., Kim, H., Sherman, D., & Taylor, S. (2011) Oxytocin receptor gene (OXTR) is related to psychological resources. Proceedings of the National Academy of Sciences, 108(37), 15118-15122. DOI: 10.1073/pnas.1113137108  

  • September 15, 2011
  • 11:35 AM

September 15, 2011

by Erin Campbell in HighMag Blog

There is something so gratifying about a light switch. My two-year old will pull a chair to our kitchen light switch to turn it on and off. Over. And over. And over again. Maybe that’s why I find phosphorylation so satisfying (and maybe why I have a headache). It’s a molecular switch, and the vast combinations of where, when, and how different proteins are phosphorylated can provide mind-numbing levels of regulation within a cell. Combine my appreciation for phosphorylation with my ab........ Read more »

Galli, M., Muñoz, J., Portegijs, V., Boxem, M., Grill, S., Heck, A., & van den Heuvel, S. (2011) aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division. Nature Cell Biology, 13(9), 1132-1138. DOI: 10.1038/ncb2315  

  • September 15, 2011
  • 11:35 AM

Protect Your Jury From the Poison of the Crowd

by Persuasion Strategies in Persuasive Litigator

By Dr. Ken Broda-Bahm - Crowds can be scary things. At a debate this past Monday (September 9th), Republican Presidential candidate, Ron Paul, was asked if his stance against government mandated health insurance would dictate denying care to a hypothetical man who found himself in a coma without the benefit of catastrophic health insurance. "Are you saying," Wolf Blitzer asked, "that society should just let him die?" In response, a chorus of voices from the audience shouted "yeah!" Less than a w........ Read more »

Lorenz J, Rauhut H, Schweitzer F, & Helbing D. (2011) How social influence can undermine the wisdom of crowd effect. Proceedings of the National Academy of Sciences of the United States of America, 108(22), 9020-5. PMID: 21576485  

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