by Jennifer Gibson, PharmD in Brain Blogger
Antidepressant medications are among the most commonly prescribed drugs in the United States – one of the top three, depending on who is counting — owing to a dramatic rise in antidepressant use in the last 10 to 15 years. A new health policy report finds, however, that this increase in antidepressant use is driven [...]... Read more »
Marcus SC, & Olfson M. (2010) National trends in the treatment for depression from 1998 to 2007. Archives of general psychiatry, 67(12), 1265-73. PMID: 21135326
Mark TL. (2010) For what diagnoses are psychotropic medications being prescribed?: a nationally representative survey of physicians. CNS drugs, 24(4), 319-26. PMID: 20297856
Mojtabai, R., & Olfson, M. (2011) Proportion Of Antidepressants Prescribed Without A Psychiatric Diagnosis Is Growing. Health Affairs, 30(8), 1434-1442. DOI: 10.1377/hlthaff.2010.1024
Olfson M, & Marcus SC. (2009) National patterns in antidepressant medication treatment. Archives of general psychiatry, 66(8), 848-56. PMID: 19652124
I’m at the #solo11 conference and as part of the blogging workshop we’re all busy writing blog summaries of Spinal Muscular Atrophy (SMA) research papers: The paper I have chosen is: Taylor, P. J. et al. Dystrophin gene mutation location and the risk of cognitive impairment in duchenne muscular dystrophy. PLoS ONE 5, e8803 (2010). [...]... Read more »
Taylor, P., Betts, G., Maroulis, S., Gilissen, C., Pedersen, R., Mowat, D., Johnston, H., & Buckley, M. (2010) Dystrophin Gene Mutation Location and the Risk of Cognitive Impairment in Duchenne Muscular Dystrophy. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008803
I live in Baton Rouge, Louisiana. Classes have started, and summer is coming to a close. We know what that means: it is hurricane season down in the Bayou. Talk about needing to be prepared and have a plan for potential dangerous situations. ... Read more »
Holland, G.J. (1993) "Ready Reckoner" Chapter 9, Global Guide to Tropical Cyclone Forecasting. WMO/TC-No. 560, Report No. TCP-31, World Meteorological Organization. info:/
Figure 2. Phylogenetic tree linking
metagenomic sequences from 31 gene
families along an oceanic depth gradient
at the HOT ALOHA site
I am a co-author on a new paper that came out in PLoS One yesterday. The paper is PLoS ONE: The Phylogenetic Diversity of Metagenomes and the full citation is Kembel SW, Eisen JA, Pollard KS, Green JL (2011) The Phylogenetic Diversity of Metagenomes. PLoS ONE 6(8): e23214. doi:10.1371/journal.pone.0023214.
The first author is Steven Kembel, a bri........ Read more »
There has been a major dust-up in the climate denialist world. A study published in late July made false claims and was methodologically flawed, but still managed to get published in a peer reviewed journal. The Editor-in-Chief of that journal has resigned to symbolically take responsibility for the journal's egregious error of publishing what is essentially a fake scientific paper, and to "protest against how the authors [and others] have much exaggerated the paper's conclusions" taking to ta........ Read more »
Spencer, R., & Braswell, W. (2011) On the Misdiagnosis of Surface Temperature Feedbacks from Variations in Earth’s Radiant Energy Balance. Remote Sensing, 3(8), 1603-1613. DOI: 10.3390/rs3081603
This spring, scientists announced that each person seems to have a signature set of gut bacteria, like a blood type for the microbiome. Their human subjects fell into three separate "enterotypes," each one representing a distinct microbial ecosystem. The enterotypes didn't correlate with subjects' age, gender, or nationality. But a new study has found something that does predict what enterotype you'll host: eating a plant- or animal-based diet.
Researchers surveyed 98 subjects about their diets........ Read more »
Wu, G., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y., Keilbaugh, S., Bewtra, M., Knights, D., Walters, W., Knight, R.... (2011) Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes. Science. DOI: 10.1126/science.1208344
This is the first part of an occasional series at Psych Your Mind that will delve into psychological experiences that contribute to (or detract from) happiness. In Part I of this series, we will discuss the potential dark side of happiness.
Over the last 20 years or so there has been an explosion of literature and accompanying research on the science of happiness. Most of this research has been devoted to understanding what makes people happy (or unhappy)? In general, the research on ........ Read more »
Gruber, J., Mauss, I., & Tamir, M. (2011) A Dark Side of Happiness? How, When, and Why Happiness Is Not Always Good. Perspectives on Psychological Science, 6(3), 222-233. DOI: 10.1177/1745691611406927
A significant advantage of Nextera™ library preparation technology is its low input requirements. A recent publication exploits this advantage to characterize the emergence and spread of a strain of new hemorrhagic fever viruses in red colobus monkeys in Uganda. Lauck et al. report that simian hemorrhagic fever virus (SHFV) has caused lethal outbreaks of hemorrhagic disease in captive primates, but has not been studied in wild primates. They describe the discovery and genetic characterizatio........ Read more »
Lauck, M. et al. (2011) Novel, Divergent Simian Hemorrhagic Fever Viruses in a Wild Ugandan Red Colobus Monkey Discovered Using Direct Pyrosequencing. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0019056
Little yummy beer yeasts, thanks www.diArk.org As our ancestors transitioned from hunter-gatherer to agricultural society, they had to domesticate the plants and animals we know today as farm life. Corn kernels became larger and more full of starch, cows became more docile, and all farm organisms became accustomed to life in rows or [...]... Read more »
Libkind, D., Hittinger, C., Valerio, E., Goncalves, C., Dover, J., Johnston, M., Goncalves, P., & Sampaio, J. (2011) From the Cover: Microbe domestication and the identification of the wild genetic stock of lager-brewing yeast. Proceedings of the National Academy of Sciences, 108(35), 14539-14544. DOI: 10.1073/pnas.1105430108
Dengue virus (DENV) particles. Does dengue interact with the host epigenome? And, why?
Epigenetic modification of chromosomal structure has the ability to rapidly and stably alter gene expression and function within cells, tissues and whole organisms. And, changes have been found to induce a number of diseases in humans, such as cancer and others.
The ability of infecting viruses to influence this process has now been realized with a number of large DNA viruses being shown to take advantag........ Read more »
Colpitts, T., Barthel, S., Wang, P., & Fikrig, E. (2011) Dengue Virus Capsid Protein Binds Core Histones and Inhibits Nucleosome Formation in Human Liver Cells. PLoS ONE, 6(9). DOI: 10.1371/journal.pone.0024365
It’s no secret that frogs and toads in the Americas, Australia, and Europe have suffered extinctions and massive declines at the hands of a chytrid fungus on a global genocidal rampage. What is much more of a mystery is exactly what a chytrid fungus is. Or, for that matter, what to do about it. I [...]... Read more »
Buck, J., Truong, L., & Blaustein, A. (2011) Predation by zooplankton on Batrachochytrium dendrobatidis: biological control of the deadly amphibian chytrid fungus?. Biodiversity and Conservation. DOI: 10.1007/s10531-011-0147-4
No, fly me, fly me, far as pole from pole;
Rise Alps between us! and whole oceans roll!
Ah, come not, write not, think not once of me,
Nor share one pang of all I felt for thee.
Thy oaths I quit, thy memory resign;
Forget, renounce me, hate whate'er was mine.
Fair eyes, and tempting looks (which yet I view!)
Long lov'd, ador'd ideas, all adieu!
Alexander Pope’s 1717 poem Eloisa to Abelard describes Eloisa’s wish to escape the suffering of separation from he........ Read more »
Maren S. (2011) Seeking a spotless mind: extinction, deconsolidation, and erasure of fear memory. Neuron, 70(5), 830-45. PMID: 21658578
Recent publications in AML research - including a video link to Dr. Maria Figueroa talk.... Read more »
Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M.... (2011) RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. PMID: 21814200
by Rita Handrich in The Jury Room
I love to read. Now, I tend to read while driving courtesy of my iPod and recorded books. And when this study first came out, I was appalled. ‘Stories are not spoiled by spoilers’. I knew intuitively that it was not true. I want to be pulled along, drawn in and surprised by a good [...]
Related posts:Voir Dire Tip: Are you ‘transported’ by a good story?
“I can look into his eyes and just tell he is lying”
Faulty Logic: Cannabis, psychosis and fish oil
... Read more »
In the blog last week, I introduced synthetic lethality as a potential strategy for cancer therapy which targets tumour cells whilst having no effect on healthy tissue. Another synthetic lethality paper has recently been published in Nature, this time targeting … Continue reading →... Read more »
Frezza C, Zheng L, Folger O, Rajagopalan KN, Mackenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A.... (2011) Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature. PMID: 21849978
An engineered virus could be the next route to combating metastatic cancer and has been assessed in early clinical trials. The vaccinia poxvirus, which has been engineered to target cancer cells and express a transgene has now been studied in patients with advanced cancer. The results showed that it was safe and well-tolerated, with cancer-selective and dose-related expression of the inserted gene.... Read more »
Caroline J. Breitbach,, James Burke,, Derek Jonker,, Joe Stephenson,, Andrew R. Haas,, Laura Q. M. Chow,, Jorge Nieva,, Tae-Ho Hwang,, Anne Moon,, Richard Patt,.... (2011) Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. Nature, 99-102. info:/10.1038/nature10358
Though science and technology in the modern era have accomplished things that our ancestors couldn’t even dream of, it is still worth remembering that the ancients weren’t dummies. Through a combination of ingenuity, observation, determination, and probably a lot of luck, these people managed to develop a number of surprising technologies — many of which have been lost to history and have proven surprisingly hard to reproduce today. Among these lost inventions are Nepenthe, an........ Read more »
Reibold, M., Paufler, P., Levin, A., Kochmann, W., Pätzke, N., & Meyer, D. (2006) Materials: Carbon nanotubes in an ancient Damascus sabre. Nature, 444(7117), 286-286. DOI: 10.1038/444286a
Americans are not well: reported levels of subjective happiness haven’t budged in years, divorce rates are hovering around 50%, and tons of money doesn’t seem to do the trick. So what’s going on? Social scientists, economists, and politicians give us their reasons, but most are speculative and lack legitimate evidence. Thankfully, psychologists are weighing in with some [...]... Read more »
Glucksberg, S. (1962) The influence of strength of drive on functional fixedness and perceptual recognition. Journal of Experimental Psychology, 63(1), 36-41. DOI: 10.1037/h0044683
I am re-posting a guest-post that I wrote in June for my friend and colleague, Travis Saunders, on his blog: 'Obesity Panacea'. I was too lazy then to put the whole thing up on my own blog...Alas, I've come back to it as potential thesis material, so have decided to take the two minutes to format it. You can also view the original post here. I am hoping that researchers and the public at large are starting to get past the ‘blame the victim’ perspective of obesity. True, choice and prefe........ Read more »
Szreter, S. (2004) Health by association? Social capital, social theory, and the political economy of public health. International Journal of Epidemiology, 33(4), 650-667. DOI: 10.1093/ije/dyh013
Female Asian elephants maintain an ever-changing network of social relationships that is far more complex than previously believed.... Read more »
Douglas-Hamilton, I. (1972) On the ecology and behaviour of the African elephant. Oxford University. info:/
WITTEMYER, G., DOUGLASHAMILTON, I., & GETZ, W. (2005) The socioecology of elephants: analysis of the processes creating multitiered social structures. Animal Behaviour, 69(6), 1357-1371. DOI: 10.1016/j.anbehav.2004.08.018
de Silva S, Ranjeewa AD, & Kryazhimskiy S. (2011) The dynamics of social networks among female Asian elephants. BMC ecology, 17. PMID: 21794147
Vidya, T., & Sukumar, R. (2005) Social organization of the Asian elephant (Elephas maximus) in southern India inferred from microsatellite DNA. Journal of Ethology, 23(2), 205-210. DOI: 10.1007/s10164-005-0144-8
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