In this month’s lab profile we highlight the work of Dr Ravi Nookala, a structural biologist working in the lab of Professor Sir Tom Blundell in the Department of Biochemistry at the University of Cambridge. Dr Nookala is working on … Continue reading →... Read more »
Nookala RK, Hussain S, & Pellegrini L. (2007) Insights into Fanconi Anaemia from the structure of human FANCE. Nucleic acids research, 35(5), 1638-48. PMID: 17308347
A. baumannii does not mess around. As opportunistic pathogens go it’s pretty out there. An aerobic, gram negative, almost entirely antibiotic resistant (largely through passive mechanisms) bacterium that’s developing such a terrible reputation that it has picked up the nickname ‘Iraqibacter’, but that’s mostly because of the high proportion of A. baumannii infections in returned American troops.... Read more »
Mussi, M., Gaddy, J., Cabruja, M., Arivett, B., Viale, A., Rasia, R., & Actis, L. (2010) The Opportunistic Human Pathogen Acinetobacter baumannii Senses and Responds to Light. Journal of Bacteriology, 192(24), 6336-6345. DOI: 10.1128/JB.00917-10
Reddy, T., Chopra, T., Marchaim, D., Pogue, J., Alangaden, G., Salimnia, H., Boikov, D., Navon-Venezia, S., Akins, R., Selman, P.... (2010) Trends in Antimicrobial Resistance of Acinetobacter baumannii Isolates from a Metropolitan Detroit Health System. Antimicrobial Agents and Chemotherapy, 54(5), 2235-2238. DOI: 10.1128/AAC.01665-09
Dijkshoorn, L., Nemec, A., & Seifert, H. (2007) An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nature Reviews Microbiology, 5(12), 939-951. DOI: 10.1038/nrmicro1789
I think I know why science does not understand the female orgasm. It is because science excels when it breaks free of context, history, human complexities and anthropology, but when a topic requires one to grasp context, history, human complexities and anthropology, then science, especially the hard sciences, can fall short. Also, the nature of the female orgasm is a comparative question, but human sexuality is highly (but not entirely) derived; It is difficult to make a sensible graph or tabl........ Read more »
Zietsch, B., & Santtila, P. (2011) Genetic analysis of orgasmic function in twins and siblings does not support the by-product theory of female orgasm. Animal Behaviour. DOI: 10.1016/j.anbehav.2011.08.002
Here’s an epigenetics first.
It turns out that intermolecular signaling in epigenetics — all that ubiquination, methylation, and so forth — doesn’t always end at DNA or histones, where those two components go on just to regulate genes (or to encourage more modification of themselves and each other). Nope, John Latham and colleagues at the University of Texas M.D. Anderson Cancer Center reported in Cell last week that there’s at least one case — in yeast &md........ Read more »
Latham, J., Chosed, R., Wang, S., & Dent, S. (2011) Chromatin Signaling to Kinetochores: Transregulation of Dam1 Methylation by Histone H2B Ubiquitination. Cell, 146(5), 709-719. DOI: 10.1016/j.cell.2011.07.025
Despite their impressive preservation, the Gila Cliff Dwellings have gotten surprisingly little attention in the archaeological literature. This is apparently because they were so thoroughly ransacked by pothunters early on that there wasn’t much left intact for archaeologists to study, and possibly also because the early establishment of Gila Cliff Dwellings National Monument in 1907 [...]... Read more »
How precise does feedback need to be in order to support behaviour change? Most of us prefer exact information and are adverse to ambiguity (1), but absolute values may not be as successful for supporting behaviour change as one might … Continue reading →... Read more »
Mishra H, Mishra A, & Shiv B. (2011) In praise of vagueness: malleability of vague information as a performance booster. Psychological science, 22(6), 733-8. PMID: 21515738
One of the highlighted Konservat-Lagerstätten in my Rise of Animals post is Chengjiang (a.k.a. the Maotianshan Shales). While Burgess has the historical significance, in terms of importance and potential, Chengjiang is arguably more important (see Shu, 2008). Chengjiang fossils are not the easiest to see, although they are admittedly abundant, at 40000+ specimens so far. [...]... Read more »
Zhu, M., Babcock, L., & Steiner, M. (2005) Fossilization modes in the Chengjiang Lagerstätte (Cambrian of China): testing the roles of organic preservation and diagenetic alteration in exceptional preservation. Palaeogeography, Palaeoclimatology, Palaeoecology, 220(1-2), 31-46. DOI: 10.1016/j.palaeo.2003.03.001
Steiner, M., Zhu, M., Zhao, Y., & Erdtmann, B. (2005) Lower Cambrian Burgess Shale-type fossil associations of South China. Palaeogeography, Palaeoclimatology, Palaeoecology, 220(1-2), 129-152. DOI: 10.1016/j.palaeo.2003.06.001
Last night I was eating dinner at Rubio's (side note: "Baja Fresh," Rubio's slogan is a little confusing considering that their fish tacos are made with Alaskan pollock, just an observation) while surfing the web using my smartphone. What I found was shocking: an article released by the Science Magazine, states that dutch social psychologist Diedrik Stapel has "admitted to using faked data" and "will not be asked to return" to Tilburg University where he is........ Read more »
Division of labor is a major part of understanding gender and class roles in historic populations. Without text, archaeologists depend on material and human remains for the answers. The physical stress (or lack thereof) from daily activities can leave markers … Continue reading →... Read more »
P. HAVELKOVA, S. VILLOTTE, P. VELEMINSKY, L. POLACEK AND M. DOBISIKOVA. (2011) Enthesopathies and Activity Patterns in the Early Medieval Great Moravian Population: Evidence of Division of Labor. International Journal of Osteoarchaeology, 487-504. info:/
In February 1942, the city of Singapore was lost to the Japanese army during the Malaya campaign of World War II. The Fall of Singapore is considered to be one of the greatest British military disasters, with over 100,000 Allied troops consisting of British, Australian, American and Dutch soldiers captured. Several thousands of these men were sent to the Thai-Burma border to finish construction of the Burma Railway, known as the "Death Railway". Several medical surveys of these former ........ Read more »
Prendki V, Fenaux P, Durand R, Thellier M, & Bouchaud O. (2011) Strongyloidiasis in man 75 years after initial exposure. Emerging infectious diseases, 17(5), 931-2. PMID: 21529417
Imagine a system where we intentionally ignore the usual horribly inaccurate trauma triage criteria, such as MOI (Mechanism Of Injury). And these are not even the usual criteria, because this is in a system with criteria already modifieded to avoid a lot of overtriage. :-)... Read more »
Teleost fish genome sequences have been absolutely essential to our understanding of vertebrate genome evolution, and to vertebrate evolution in general. Last month I welcomed the addition of the Atlantic cod genome to the sequenced fish genomes, and highlighted some of the main findings of the first analysis of the whole genome sequence. The preliminary genome database is now available for browsing at the Pre!Ensembl database.
After I had written that post, I had some notes left over becaus........ Read more »
Star, B., Nederbragt, A., Jentoft, S., Grimholt, U., Malmstrøm, M., Gregers, T., Rounge, T., Paulsen, J., Solbakken, M., Sharma, A.... (2011) The genome sequence of Atlantic cod reveals a unique immune system. Nature. DOI: 10.1038/nature10342
Judging by its starlight and gas content (as seen in the image above), Eris looks to be a near match for our own Milky Way galaxy — except that it exists only as a simulation inside a supercomputer...... Read more »
Javiera Guedes, Simone Callegari, Piero Madau, & Lucio Mayer. (2011) Forming Realistic Late-Type Spirals in a LCDM Universe: The Eris Simulation. Astrophysical Journal. arXiv: 1103.6030v2
by Persuasion Strategies in Persuasive Litigator
Your case has finally gone to the jury, and the panel is now ensconced in the jury room. What are they doing in there? Are they carefully and logically arguing the merits of your case, considering all sides until the truth wins out? If you have ever watched a closed-circuit feed of mock jury deliberations, or talked in detail with actual jurors after a verdict, you know the answer is, "No, not really doing that." What they are likely doing instead is using argument instrumentally, as a tool ........ Read more »
Mercier H, & Sperber D. (2011) Why do humans reason? Arguments for an argumentative theory. The Behavioral and brain sciences, 34(2), 57. PMID: 21447233
A few weeks ago I was discussing possible relevant papers for the Twitter Journal Club (Hashtag #TwitJC), a succesful initiative on Twitter, that I have discussed previously here and here [7,8]. I proposed an article, that appeared behind a paywall. Annemarie Cunningham (@amcunningham) immediately ran the idea down, stressing that open-access (OA) is a pre-requisite for the TwitJC [...]... Read more »
Björk, B., Welling, P., Laakso, M., Majlender, P., Hedlund, T., & Guðnason, G. (2010) Open Access to the Scientific Journal Literature: Situation 2009. PLoS ONE, 5(6). DOI: 10.1371/journal.pone.0011273
Matsubayashi, M., Kurata, K., Sakai, Y., Morioka, T., Kato, S., Mine, S., & Ueda, S. (2009) Status of open access in the biomedical field in 2005. Journal of the Medical Library Association : JMLA, 97(1), 4-11. DOI: 10.3163/1536-5050.97.1.002
Murali NS, Murali HR, Auethavekiat P, Erwin PJ, Mandrekar JN, Manek NJ, & Ghosh AK. (2004) Impact of FUTON and NAA bias on visibility of research. Mayo Clinic proceedings. Mayo Clinic, 79(8), 1001-6. PMID: 15301326
Carney PA, Poor DA, Schifferdecker KE, Gephart DS, Brooks WB, & Nierenberg DW. (2004) Computer use among community-based primary care physician preceptors. Academic medicine : journal of the Association of American Medical Colleges, 79(6), 580-90. PMID: 15165980
Krieger, M., Richter, R., & Austin, T. (2008) An exploratory analysis of PubMed's free full-text limit on citation retrieval for clinical questions. Journal of the Medical Library Association : JMLA, 96(4), 351-355. DOI: 10.3163/1536-5050.96.4.010
Daily work-related energy expenditure over the last half-century in the U.S. has decreased by over 100 calories. This may well explain the increase in body weights we’ve seen, according to a 2011 article in PLoS ONE.
I sorta hate to open this can o’ worms, but it’s important. As a population, are we fat because we eat too much [...]... Read more »
Church, T., Thomas, D., Tudor-Locke, C., Katzmarzyk, P., Earnest, C., Rodarte, R., Martin, C., Blair, S., & Bouchard, C. (2011) Trends over 5 Decades in U.S. Occupation-Related Physical Activity and Their Associations with Obesity. PLoS ONE, 6(5). DOI: 10.1371/journal.pone.0019657
During a pivotal scene in West Side Story, the Jets and the Sharks meet to prepare to rumble. As the gangs assembled each side likely tried to assess their opponent’s strength. This ability to assess numerical advantage is highly advantageous in any species where conflict between groups is common.
Spotted hyenas (Crocuta crocuta) live in large fission-fussion clans where smaller groups often forage separately (Figure 1). The composition and size of these subgroups varies over time ........ Read more »
Benson-Amram, S., Heinen, V., Dryer, S., & Holekamp, K. (2011) Numerical assessment and individual call discrimination by wild spotted hyaenas, Crocuta crocuta. Animal Behaviour. DOI: 10.1016/j.anbehav.2011.07.004
Researchers have long known about regeneration of injured muscles, and have debated about the exact source of the muscle stem cells that perform this amazing feat. A group of papers in a recent issue of Development shine a stem cell spotlight on satellite cells. Following injury, skeletal muscles are regenerated by muscle stem cells, but [...]... Read more »
Lepper, C., Partridge, T., & Fan, C. (2011) An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration. Development, 138(17), 3639-3646. DOI: 10.1242/dev.067595
More evidence that acacia trees had a role to play in the evolution of langauge.... Read more »
Sean Geraint. (2011) Language Evolution and the Acacia Tree. Speculative Grammarian, Vol CLXII(4). info:/
A interesting history lesson & discussion on the 100 year old debate - are viruses alive?... Read more »
Moreira D, & López-García P. (2009) Ten reasons to exclude viruses from the tree of life. Nature reviews. Microbiology, 7(4), 306-11. PMID: 19270719
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