Argyll Robertson pupils (“AR pupils”) are bilateral small pupils that constrict when the patient focuses on a near object (they “accommodate”), but do not constrict when exposed to bright light (they do not “react” to light). This condition is colloquially … Continue reading →... Read more »
Timoney PJ, & Breathnach CS. (2010) Douglas Argyll Robertson (1837-1909) and his pupil. Irish journal of medical science, 179(1), 119-21. PMID: 20069387
by in Beaker
Researchers have been working for decades to develop nanoparticles that deliver cancer drugs directly to tumors, minimizing the toxic side effects of chemotherapy. However, even with the best nanoparticles, only small amounts of the treatment actually reach the tumor. Scientists at MIT, Sanford-Burnham and the University of California, San Diego (UCSD) may have found a [...]... Read more »
von Maltzahn, G., Park, J., Lin, K., Singh, N., Schwöppe, C., Mesters, R., Berdel, W., Ruoslahti, E., Sailor, M., & Bhatia, S. (2011) Nanoparticles that communicate in vivo to amplify tumour targeting. Nature Materials, 10(7), 545-552. DOI: 10.1038/nmat3049
Vilazodone was approved by the Food and Drug Administration in the U.S. earlier this year, but is just now becoming available in pharmacies for prescription use. The drug is marketed in the U.S. under the trade name Viibyd. It is novel in that it the only antidepressant that combines two mechanisms that can increase serotonin in the brain cortex: selective serotonin reuptake inhibition and partial agonism of the 5HT1A receptor. There are multiple selective serotonin reuptake in........ Read more »
Rickels K, Athanasiou M, Robinson DS, Gibertini M, Whalen H, & Reed CR. (2009) Evidence for efficacy and tolerability of vilazodone in the treatment of major depressive disorder: a randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry, 70(3), 326-33. PMID: 19284933
Khan A, Cutler AJ, Kajdasz DK, Gallipoli S, Athanasiou M, Robinson DS, Whalen H, & Reed CR. (2011) A randomized, double-blind, placebo-controlled, 8-week study of vilazodone, a serotonergic agent for the treatment of major depressive disorder. The Journal of clinical psychiatry, 72(4), 441-7. PMID: 21527122
If your organisation puts time and effort into implementing best practise HR methods, such as ability testing, it must be reassuring to to know it all pays off in the end. Or does it? A recent study involving US financial organisations casts doubt on this belief.Oksana Drogan and George Yancey were interested in six recruitment technologies generally considered as 'best practice': job analysis to see what a candidate needs to perform well; monitoring the effectiveness of recruitment sources; us........ Read more »
Drogan, O., & Yancey, G. (2011) Financial Utility of Best Employee Selection Practices at Organizational Level of Performance. The Psychologist-Manager Journal, 14(1), 52-69. DOI: 10.1080/10887156.2011.546194
We often talk, often rather vaguely, about instincts and how they shape our behavior (my instinctive reaction was…, etc.). Predator-prey interactions are one place where instincts are real, and really matter. A cat that doesn’t realize that a little scuttling squeaky thing is also a good meal probably won’t be welcome in the barn of [...]... Read more »
Ferrero DM, Lemon JK, Fluegge D, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, & Liberles SD. (2011) Detection and avoidance of a carnivore odor by prey. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21690383
Speaking of protein folding, here's something interesting. One of the most enduring views of protein folding from the last decade is that of an "energy funnel". The funnel was invented by the UCSD chemist Peter Wolynes in the 90s (the original paper is highly readable) and essentially depicts a plot of the configurational enthalpy (or effective energy) of the protein on the Y axis vs the configurational entropy on the X axis. In real situations this plot is multidimensional.The funnel suggests ........ Read more »
Here is what the authors of a recently published research paper from the esteemed journal Pediatrics have to say about the children watching television in the evening prior to turning in (and especially if the content is violent in nature): Conclusions: Violent content and evening media use were associated with increased sleep problems. However, no such [...]
Related posts:Varenicline: Cardio Vascular Adverse Effects
... Read more »
Garrison, M., Liekweg, K., & Christakis, D. (2011) Media Use and Child Sleep: The Impact of Content, Timing, and Environment. PEDIATRICS. DOI: 10.1542/peds.2010-3304
Despite all advances in gender equality, mothers overwhelmingly remain responsible for putting food on the family table.
Thus, any attempt at changing eating behaviours requires a sound understanding of the factors that determine mothers’ food choices for their families.
This issue is the topic of a study by Joyce Slater and colleagues from the University of Manitoba, [...]... Read more »
Slater J, Sevenhuysen G, Edginton B, & O'neil J. (2011) 'Trying to make it all come together': structuration and employed mothers' experience of family food provisioning in Canada. Health promotion international. PMID: 21693474
Already some time ago I wrote about Systematic Review, a literature analysis approach that should lead to a well founded overview of a specific research field. Since I left out the history and some insights last time I wanted to extend on my last article here. Continue reading "Follow Up: Systematic Review"
... Read more »
Tranfield, D., Denyer, D., & Smart, P. (2003) Towards a Methodology for Developing Evidence-Informed Management Knowledge by Means of Systematic Review. British Journal of Management, 14(3), 207-222. DOI: 10.1111/1467-8551.00375
by Rita Handrich in The Jury Room
Here’s some research that flies in the face of the common wisdom “what is pretty is good”. Most of us have seen (or heard about) the research that says physically attractive people tend to make better initial impressions on others. It seems that there is some fine print that goes with that adage, and you [...]
Related posts:I never knew Hitler had three testicles…
“I can see it from both sides”
... Read more »
Agthe M, Spörrle M, & Maner JK. (2011) Does being attractive always help? Positive and negative effects of attractiveness on social decision making. Personality , 37(8), 1042-54. PMID: 21636731
This will be the first in a series of posts looking at the technical and practical aspects of studying ancient pathogens, or paleomicrobiology. First let’s look at why its worth spending time, money and a lot of creativity on old germs. There are many reasons why directly studying ancient microbes is worthwhile. From a historical [...]... Read more »
Drancourt, M., & Raoult, D. (2005) Palaeomicrobiology: current issues and perspectives. Nature Reviews Microbiology, 3(1), 23-35. DOI: 10.1038/nrmicro1063
Furuse Y, Suzuki A, & Oshitani H. (2010) Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries. Virology journal, 52. PMID: 20202190
Nelson, M., Dinardo, A., Hochberg, J., & Armelagos, G. (2010) Brief communication: Mass spectroscopic characterization of tetracycline in the skeletal remains of an ancient population from Sudanese Nubia 350-550 CE. American Journal of Physical Anthropology. DOI: 10.1002/ajpa.21340
Too often we will look at just the rare, but well publicized error. We ignore all of the otherwise overwhelming accuracy. We are frequently far less accurate at assessment than those we condemn.
If we do not measure what we are doing, we probably will be wildly inaccurate in our estimation of our performance.
... Read more »
Pickhardt PJ, Lawrence EM, Pooler BD, & Bruce RJ. (2011) Diagnostic performance of multidetector computed tomography for suspected acute appendicitis. Annals of internal medicine, 154(12), 789-96. PMID: 21690593
An interesting and refreshing paper from Simon Baron-Cohen's autism group from Cambridge. The results themselves are pretty boring - they found that people with autism have normal vision.But the story behind it is rather spicy.Back in 2009, a Cambridge group - different authors, but led by "SBC", published a report claiming that people with autism have exceptionally acute vision. Their average visual acuity was claimed to be 2.8On this scale, 1.0 is defined as normal, and a sharp-eyed young adul........ Read more »
Tavassoli T, Latham K, Bach M, Dakin SC, & Baron-Cohen S. (2011) Psychophysical measures of visual acuity in autism spectrum conditions. Vision research. PMID: 21704058
Each culture has its agreed-upon list of taboo words and it doesn't matter how many times these words are repeated, they still seem to retain their power to shock. Scan a human brain, swear at it, and you'll see its emotional centres jangle away.
Recent research has shown that this emotional impact can have an analgesic effect, and there's other evidence that strategically deployed swear words can make a speech more memorable. But it's not all positive. A new study suggests that swear words hav........ Read more »
Robbins, M., Focella, E., Kasle, S., López, A., Weihs, K., & Mehl, M. (2011) Naturalistically observed swearing, emotional support, and depressive symptoms in women coping with illness. Health Psychology. DOI: 10.1037/a0023431
Today Sci is going to blog a paper that she has been meaning to blog for a long time. It's one of those papers that people who do certain kinds of science snuggle with when they go to sleep at night. (Sci and this paper) But the real reason that Sci loves this paper is [...]... Read more »
The Basketmaker III period (ca. AD 500 to 750) is a very important time for understanding the prehistoric Southwest. Maize agriculture had been introduced earlier, although exactly how early is still a matter of debate, and it was definitely well-established by the immediately preceding Basketmaker II period, but Basketmaker III saw the introduction of beans, [...]... Read more »
Wills, W., & Windes, T. (1989) Evidence for Population Aggregation and Dispersal during the Basketmaker III Period in Chaco Canyon, New Mexico. American Antiquity, 54(2), 347. DOI: 10.2307/281711
TweetReduction in pain and disability with a graded sensorimotor retraining program in chronic back pain Our team recently returned home from Darwin, where we all attended the Australian Pain Society’s Annual Scientific Meeting. We all presented some of our work up there and had a lot of fun while we were at it. I presented [...]... Read more »
van Tulder MW, Koes B, & Malmivaara A. (2006) Outcome of non-invasive treatment modalities on back pain: an evidence-based review. European spine journal. PMID: 16320031
For PDFs of this entire talk series, click here! [17.62MB rar file with 6 PDFs] This talk is split into two major parts: the first will look at the general fossil record of insects, and the second will introduce the flowering plants and their interactions with insects. Due to the constructive feedback received in the [...]... Read more »
Compton, S., Ball, A., Collinson, M., Hayes, P., Rasnitsyn, A., & Ross, A. (2010) Ancient fig wasps indicate at least 34 Myr of stasis in their mutualism with fig trees. Biology Letters, 6(6), 838-842. DOI: 10.1098/rsbl.2010.0389
Rust, J., Singh, H., Rana, R., McCann, T., Singh, L., Anderson, K., Sarkar, N., Nascimbene, P., Stebner, F., Thomas, J.... (2010) Biogeographic and evolutionary implications of a diverse paleobiota in amber from the early Eocene of India. Proceedings of the National Academy of Sciences, 107(43), 18360-18365. DOI: 10.1073/pnas.1007407107
Lidgard, S., & Crane, P. (1988) Quantitative analyses of the early angiosperm radiation. Nature, 331(6154), 344-346. DOI: 10.1038/331344a0
Friedhelm Eichmann. (2003) Aus dem Leben im Bernsteinwald. Arbeitskreis Paläontologie Hannover, 31(4), 89-94. info:/
An amusing semi-anthropological study was published in JAMA by Ludwig and Levine in 1965. It was based on extensive interviews with 27 "postnarcotic drug addict inpatients" who were treated at a hospital in Lexington, Kentucky. The specific drugs of interest included peyote (from the peyotl cactus plant), mescaline, LSD, and psilocybin. The current availability of each drug, most popular methods of intake, slang terms, psychoactive properties, and subcultural norms were discussed. Hallucinogens ........ Read more »
Stuck in a bad relationship are you? Join the club. Many members of the animal kingdom are ‘doing it’ with mediocre mates on a daily basis for a variety of reasons including the lack of ability to find someone better, forced copulations, social protocols and much more. But have you ever considered that hooking up [...]... Read more »
Pryke, S., Rollins, L., Buttemer, W., & Griffith, S. (2011) Maternal stress to partner quality is linked to adaptive offspring sex ratio adjustment. Behavioral Ecology, 22(4), 717-722. DOI: 10.1093/beheco/arr040
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