Want to rediscover an “extinct” mammal? Start by looking for a critter that researchers believe was done in by habitat loss within the last 100 years. Your odds of bringing it back from the dead aren’t too bad, concludes a provocative new study. It also suggests that conservation biologists stop wasting their time and money […] Read More »... Read more »
Fisher, D., & Blomberg, S. (2010) Correlates of rediscovery and the detectability of extinction in mammals. Proceedings of the Royal Society B: Biological Sciences. DOI: 10.1098/rspb.2010.1579
Do you drink coffee on a regular basis? I do. And what does drinking coffee have to do with acute ischemic stroke? In a study published in Neurology, Mostofsky and colleagues investigated the relationship between drinking caffeinated coffee and the risk of acute ischemic stroke in the next hour. Using a case-crossover design, each subject served as his/her own control. All the subjects were patients with a confirmed diagnosis of ischemic stroke. Coffee consumption information one hour before the........ Read more »
Mostofsky E, Schlaug G, Mukamal KJ, Rosamond WD, & Mittleman MA. (2010) Coffee and acute ischemic stroke onset: The Stroke Onset Study. Neurology. PMID: 20881275
I have previously posted a review of the brain imaging applications Brain Tutor and 3D Brain. My original review of the two applications for the iPhone and iPod Touch is located here and a review of the applications for the iPad are located here.The original iPad review noted that the iPad versions of both applications were essentially the iPhone version with the common 2x modification that essential doubles the size of the image to accommodate the larger screen with the iPad. There ........ Read more »
Estevez ME, Lindgren KA, & Bergethon PR. (2010) A novel three-dimensional tool for teaching human neuroanatomy. Anatomical sciences education. PMID: 20939033
Parents take note: if you want your kids to grow bigger brains, think twice about letting schools cut recess or skimp on physical education.
Animal and human studies have long shown that exercise increases neurogenesis, especially in memory- and learning-related areas of the brain. More recently, research on human adolescents has not only confirmed these findings, but highlighted the importance of physical activity for children.... Read more »
van Praag, H. (1999) Running enhances neurogenesis, learning, and long-term potentiation in mice. Proceedings of the National Academy of Sciences, 96(23), 13427-13431. DOI: 10.1073/pnas.96.23.13427
Praag, H. (2008) Neurogenesis and Exercise: Past and Future Directions. NeuroMolecular Medicine, 10(2), 128-140. DOI: 10.1007/s12017-008-8028-z
Chaddock, L., Erickson, K., Prakash, R., VanPatter, M., Voss, M., Pontifex, M., Raine, L., Hillman, C., & Kramer, A. (2010) Basal Ganglia Volume Is Associated with Aerobic Fitness in Preadolescent Children. Developmental Neuroscience, 32(3), 249-256. DOI: 10.1159/000316648
Chaddock, L., Erickson, K., Prakash, R., Kim, J., Voss, M., VanPatter, M., Pontifex, M., Raine, L., Konkel, A., & Hillman, C. (2010) A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Research, 172-183. DOI: 10.1016/j.brainres.2010.08.049
Åberg, E., Hofstetter, C., Olson, L., & Brené, S. (2005) Moderate ethanol consumption increases hippocampal cell proliferation and neurogenesis in the adult mouse. The International Journal of Neuropsychopharmacology, 8(04), 557. DOI: 10.1017/S1461145705005286
van Praag, H., Lucero, M., Yeo, G., Stecker, K., Heivand, N., Zhao, C., Yip, E., Afanador, M., Schroeter, H., Hammerstone, J.... (2007) Plant-Derived Flavanol (-)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice. Journal of Neuroscience, 27(22), 5869-5878. DOI: 10.1523/JNEUROSCI.0914-07.2007
Jiang, W. (2005) Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. Journal of Clinical Investigation, 115(11), 3104-3116. DOI: 10.1172/JCI25509
DOWNER, E., & CAMPBELL, V. (2009) Phytocannabinoids, CNS cells and development: A dead issue?. Drug and Alcohol Review, 29(1), 91-98. DOI: 10.1111/j.1465-3362.2009.00102.x
If successful, virtual screening (VS) promises to become an efficient way to find new pharmaceutical hits, competitive with high-throughput screening (HTS). Briefly, virtual screening screens libraries of millions of compounds to find new and diverse hits, either based on similarity to a known active or by complementarity to a protein binding site. The former protocol is called ligand-based VS (LBVS) and the latter is called structure-based VS (SBVS). In a typical VS campaign, either LBVS or SBV........ Read more »
Ripphausen, P., Nisius, B., Peltason, L., & Bajorath, J. (2010) Quo Vadis, Virtual Screening? A Comprehensive Survey of Prospective Applications. Journal of Medicinal Chemistry, 2147483647. DOI: 10.1021/jm101020z
One of the biggest dinosaur stories of 2009 was the discovery of a pint-sized tyrant called Raptorex. Described by a team of paleontologists led by Paul Sereno and dated to about 126 million years ago, the dinosaur showed that many definitive tyrannosaur characteristics—such a puny forearms—evolved when the predators were still small. But a story [...]... Read more »
Sereno, P., Tan, L., Brusatte, S., Kriegstein, H., Zhao, X., & Cloward, K. (2009) Tyrannosaurid Skeletal Design First Evolved at Small Body Size. Science, 326(5951), 418-422. DOI: 10.1126/science.1177428
The recent, brief foray into Shoebill territory made now a sensible time to use a few other Shoebill-based images I have here in the Tet Zoo archives. That, and I haven't been able to finish anything more substantive due to other commitments. We begin with a lateral view of a skull I once photographed - sorry about the crazy colours, once again my fantastic photographic skills have done me proud (this image is a scan of a piece of special paper featuring the image... I think it's called a phot........ Read more »
Mayr, G. (2003) The phylogenetic affinities of the Shoebill (Balaeniceps rex). Journal of Ornithology, 144(2), 157-175. DOI: 10.1007/BF02465644
Which makes you happier—thinking about time or money? A new study published in Psychological Science finds that people who are made to think about time plan to spend more of ... Read more »
Mogilner, C. (2010) The pursuit of happiness: time, money, and social connection. Psychological science : a journal of the Association for Psychological Science/ APS. PMID: 20732902
Many of you know that as a post-doc in Uri Alon’s lab, Galit Lahav caused a small revolution in our understanding of how the p53 network responds to DNA damage. By looking at single cells instead of populations, she showed that individual cells responding to the damage caused by gamma-irradiation show a series of stereotyped [...]... Read more »
Loewer A, Batchelor E, Gaglia G, & Lahav G. (2010) Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell, 142(1), 89-100. PMID: 20598361
Thanks to Ben Goldacre and Vaughan Bell, I learned this morning of an interesting paper in British Medical Journal that analyzed substantial unpublished data from Pfizer on their norephinephrine reuptake inhibitor antidepressant, reboxetine. Sold in Europe as a pair of enantiomers under the trade name Edronax, reboxetine’s US application was rejected by the FDA in [...]... Read more »
Wieseler, B., McGauran, N., & Kaiser, T. (2010) Finding studies on reboxetine: a tale of hide and seek. BMJ, 341(oct12 1). DOI: 10.1136/bmj.c4942
For what may appear rather unimaginative, obesity researchers seem to like the acronym APPLE(S) for their studies.
Thus, some readers may be aware that there is an ongoing APPLE School project led by the University of Alberta, which looks at school interventions to prevent childhood obesity.
In a paper just published in BMC Health Services Research, we [...]... Read more »
Padwal RS, Majumdar SR, Klarenbach SW, Birch DW, Karmali S, McCargar L, Fassbender K, & Sharma AM. (2010) The Alberta population-based prospective evaluation of the quality of life outcomes and economic impact of bariatric surgery (APPLES) study: background, design and rationale. BMC health services research, 10(1), 284. PMID: 20932316
How many different roles do you play in your career? Is thinking about roles rather than traits a better way to explore careers?... Read more »
Attentive readers of this blog will recall an interesting experiment run by Richard Lankau of UC Davis and others a couple of years back which looked at how genetic diversity can help maintain species diversity in a model ecosystem. There’s now a new paper out by Dr Lankau which investigates in more detail the mechanism [...]... Read more »
Lankau, R., Wheeler, E., Bennett, A., & Strauss, S. (2010) Plant-soil feedbacks contribute to an intransitive competitive network that promotes both genetic and species diversity. Journal of Ecology. DOI: 10.1111/j.1365-2745.2010.01736.x
From Millennium – Journal of International Studies The Criminal Tribunal for the Former Yugoslavia (ICTY) has acted as a prototype for international criminal justice in the aftermath of violent conflict and stated that ‘those who perpetrate horrific war crimes, genocide, and crimes against humanity will not go unpunished’. It poses the question if such differentiation [...]... Read more »
A year has passed since the first cases of Influenza A H1N1 in Mexico, we had over 18000 deaths confirmed by lab diagnosis and reported to WHO. Surely an underestimate of the total number of cases.
The average mortality was of 0.5% of the confirmed cases, close to the seasonal flu. The mortality values varied a [...]... Read more »
Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza, Bautista E, Chotpitayasunondh T, Gao Z, Harper SA, Shaw M, Uyeki TM, Zaki SR, Hayden FG, Hui DS.... (2010) Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. The New England journal of medicine, 362(18), 1708-19. PMID: 20445182
Previously, I wrote about the use of neuroscience in the courtroom as a defense for criminal actions. I asserted that these arguments hold water only insofar as they can demonstrate a clear causal connection between the brain injury and the criminal behavior, and that it was not possible for the defendant to control himself in the presence of such a brain injury.Although I am a card-carrying pinko, I am enjoying the new book by Gene Heyman, Addiction: A Disorder of Choice. (A longer review post ........ Read more »
Job V, Dweck CS, & Walton GM. (2010) Ego Depletion--Is It All in Your Head?: Implicit Theories About Willpower Affect Self-Regulation. Psychological science : a journal of the American Psychological Society / APS. PMID: 20876879
In a fascinating new article in PLOS One (open access), Daniel Nettle asks why we see social gradients in preventative health behaviors:
People of lower socioeconomic position have been found to smoke more, exercise less, have poorer diets, comply less well with therapy, use medical services less, adopt fewer safety measures, ignore health advice more, and [...]... Read more »
Nettle, D. (2010) Why Are There Social Gradients in Preventative Health Behavior? A Perspective from Behavioral Ecology. PLoS ONE, 5(10). DOI: 10.1371/journal.pone.0013371
EXECUTIVE SUMMARY: A small, exploratory British study of preschoolers with either autism or Down syndrome and typically developing toddlers looked at how each group of children acted toward their reflections in a mirror. They looked for trends, both group trends (i.e., how do autistic children differ from their non-autistic developmental peers, represented in different ways by the Down syndrome group and the younger typically developing group, whose chronological age matched the developmental ag........ Read more »
Reddy, V., Williams, E., Costantini, C., & Lan, B. (2010) Engaging with the self: Mirror behaviour in autism, Down syndrome and typical development. Autism, 14(5), 531-546. DOI: 10.1177/1362361310370397
Masatoshi Kataoka (National Institute of Advanced Industrial Science and Technology, Japan) and coworkers have developed technology for fast, cheap, reliable, and sensitive malaria diagnosis. This news feature was written on October 13, 2010.... Read more »
Yatsushiro, S., Yamamura, S., Yamaguchi, Y., Shinohara, Y., Tamiya, E., Horii, T., Baba, Y., & Kataoka, M. (2010) Rapid and Highly Sensitive Detection of Malaria-Infected Erythrocytes Using a Cell Microarray Chip. PLoS ONE, 5(10). DOI: 10.1371/journal.pone.0013179
A ‘lite’ review of an attempt to improve motif screening of genomes using additional data. Considering local minima of histone acetylation in a context of high histone acetylation may be one way forward.
A number of years ago at a biotechnology sector after-talk drinks I found myself trying to convince a CEO that often the better [...]... Read more »
Ramsey, S., Knijnenburg, T., Kennedy, K., Zak, D., Gilchrist, M., Gold, E., Johnson, C., Lampano, A., Litvak, V., Navarro, G.... (2010) Genome-wide histone acetylation data improve prediction of mammalian transcription factor binding sites. Bioinformatics, 26(17), 2071-2075. DOI: 10.1093/bioinformatics/btq405
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