This weeks journal club was on Cryptococcus neoformans and an odd way it may get of out macrophage some of the time, at least in vitro, maybe. The paper in question is:
The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by Arp2/3 Complex-Mediated Actin Polymerisation by Simon A. Johnston, Robin C. May. PLoS Pathogens 6(8) e1001041.
This work follows up a really cool observation published by t........ Read more »
Johnston SA, & May RC. (2010) The human fungal pathogen Cryptococcus neoformans escapes macrophages by a phagosome emptying mechanism that is inhibited by Arp2/3 complex-mediated actin polymerisation. PLoS pathogens, 6(8). PMID: 20714349
I recently had the opportunity to visit the fabled heart of the USDA-ARS empire: Beltsville.
I heard all about the tornado that knocked down all the campus trees, smashed in the greenhouses and threw doors down hallways a few years ago, visited their food sensory lab (a controlled environment where fruit samples are passed through a wall to waiting taste testers), and saw greenhouses packed full of cacao (where research on one of my favorite fungi, Crinipellis perniciosa, is co-f........ Read more »
Lightbourn, G., Griesbach, R., Novotny, J., Clevidence, B., Rao, D., & Stommel, J. (2008) Effects of Anthocyanin and Carotenoid Combinations on Foliage and Immature Fruit Color of Capsicum annuum L. Journal of Heredity, 99(2), 105-111. DOI: 10.1093/jhered/esm108
Stommel, J.R., & Griesbch, R.J. (2008) Inheritance of Fruit, Foliar, and Plant Habit Attributes in Capsicum. J. Amer. Soc. Hort. Sci., 113(3), 396-407. info:/
Tanaka Y, Brugliera F, Kalc G, Senior M, Dyson B, Nakamura N, Katsumoto Y, & Chandler S. (2010) Flower color modification by engineering of the flavonoid biosynthetic pathway: practical perspectives. Bioscience, biotechnology, and biochemistry, 74(9), 1760-9. PMID: 20834175
As writers, we're always trying to find words that perfectly capture our meaning. "I broke the cookie jar" has a different feel than "The cookie jar broke." But does it really matter? Would the average reader really notice the difference? A recent study suggests that subtle wording changes can have real psychological effects.
Psychologist from Stanford University were interested in the distinction between agentive (a.k.a. transitive) or nonagentive (a.k.a. nontransitive) verbs. For exampl........ Read more »
Fausey CM, & Boroditsky L. (2010) Subtle linguistic cues influence perceived blame and financial liability. Psychonomic bulletin , 17(5), 644-50. PMID: 21037161
We don't usually comment on stuff from the main palliative care journals, but the Journal of Palliative Medicine published a study that supplements the NEJM trial on early palliative care in metastatic non-small lung cancer. (See our initial reactions to the NEJM study here, here, and here.) The present study examines the content and length of time spent during the initial outpatient consultation that took place during the trial.
In the study, palliativ........ Read more »
Jacobsen, J., Jackson, V., Dahlin, C., Greer, J., Perez-Cruz, P., Billings, J., Pirl, W., & Temel, J. (2011) Components of Early Outpatient Palliative Care Consultation in Patients with Metastatic Nonsmall Cell Lung Cancer. Journal of Palliative Medicine, 2147483647. DOI: 10.1089/jpm.2010.0382
The fields of immunology, microbiology, nutrition, epigenetics and metabolism are rapidly converging utilising a systems biology methodology to explain our intimate relationships with our microbial cohabitants. For over 30 years data has been building to scientifically support the hypothesis that intestinal cohabitants operate in a collective manner with macro and micro food intakes to shape and define our immune systems from an early age. The result is a collective impact bound by mutual cooper........ Read more »
Rook, G. (2009) Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis. Immunology, 126(1), 3-11. DOI: 10.1111/j.1365-2567.2008.03007.x
Heijtz RD, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, & Pettersson S. (2011) Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences of the United States of America, 108(7), 3047-52. PMID: 21282636
Recent news about deforestation in the Amazon has been pretty positive: Deforestation has stabilized since the turn of the century, and Brazil, it seems, is on track to meet its stated goals for reducing deforestation and associated greenhouse gas emissions.
Still, the long-term story is one of significant deforestation, primarily to make room for agriculture. Whether agricultural and biofuels expansion dramatically affects the carbon and biodiversity of the world’s forests will largely d........ Read more »
Gibbs, H., Ruesch, A., Achard, F., Clayton, M., Holmgren, P., Ramankutty, N., & Foley, J. (2010) Tropical forests were the primary sources of new agricultural land in the 1980s and 1990s. Proceedings of the National Academy of Sciences, 107(38), 16732-16737. DOI: 10.1073/pnas.0910275107
How do you distill the past 40 years addiction research into ten essential messages? Prof Doug Sellman attempted this last year in a paper in the journal Addiction. Do you agree? ... Read more »
Sellman D. (2010) The 10 most important things known about addiction. Addiction (Abingdon, England), 105(1), 6-13. PMID: 19712126
by Vincent Racaniello in virology blog
A second virophage has been identified. The name does not signify a virus that infects another virus – it means virus eater. The story of virophages begins with the giant mimivirus, originally isolated from a cooling tower in the United Kingdom. It is the largest known virus, with a capsid 750 nanometers in diameter and [...]... Read more »
Fischer MG, & Suttle CA. (2011) A Virophage at the Origin of Large DNA Transposons. Science (New York, N.Y.). PMID: 21385722
Conflicts often fracture along religious lines - the Balkans, Israel/Palestine, Northern Ireland to name just a few of the best known. But it's hard to say that religion is the cause of the problem. There are always other factors, like ethnic differences, disputes over land rights and
So what's going on here? Is religion really the cause of conflict, or is it just an innocent bystander?
In a recent analysis of survey data from 30 European countries Malina Voicu, a sociologist at the Universit........ Read more »
Voicu, M. (2011) Effect of Nationalism on Religiosity in 30 European Countries. European Sociological Review. DOI: 10.1093/esr/jcq067
All couples struggle with incompatibilities within their relationship. But for some, the tension is acute and the arguments exhausting and repetitive. How can couples best deal with their differences without losing hope about the future of their relationship? Focusing on changing the problem usually results in defensiveness and only short-term changes. Practicing acceptance may be the key to see couples back to calm connection.... Read more »
Cordova, J., Jacobson, N., & Christensen, A. (1998) ACCEPTANCE VERSUS CHANGE INTERVENTIONS IN BEHAVIORAL COUPLE THERAPY: IMPACT ON COUPLES' IN-SESSION COMMUNICATION. Journal of Marital and Family Therapy, 24(4), 437-455. DOI: 10.1111/j.1752-0606.1998.tb01099.x
South, S., Doss, B., & Christensen, A. (2010) Through the Eyes of the Beholder: The Mediating Role of Relationship Acceptance in the Impact of Partner Behavior. Family Relations, 59(5), 611-622. DOI: 10.1111/j.1741-3729.2010.00627.x
Researchers have identified a more specified, reciprocal relationship between the occurrence of sleep deprivation and the activation of the neuroinflammatory response. ... Read more »
Wisor JP, Schmidt MA, & Clegern WC. (2011) Evidence for neuroinflammatory and microglial changes in the cerebral response to sleep loss. Sleep, 34(3), 261-72. PMID: 21358843
Clinicians and individuals with depression understand the tendency for depression to be associated with over-interpretation of negative cues in the environment. Depression seems to heighten perception of negative environmental cues including interpersonal (or social) cues. The cognitive behavioral model of depression emphasizes the cognitive triad—a negative bias (view) of the self, the environment and the future.Functional magnetic resonance imaging is providing a model to s........ Read more »
Victor TA, Furey ML, Fromm SJ, Ohman A, & Drevets WC. (2010) Relationship between amygdala responses to masked faces and mood state and treatment in major depressive disorder. Archives of general psychiatry, 67(11), 1128-38. PMID: 21041614
I had my annual viewing of Susan Boyle on Britain’s got talent this morning. Then I came across this amazing demonstration of what photoshop can do. Is it possible that if you think you look a particular way, your body changes the way it works to match that?... Read more »
Wansink, B. (2005) Shape of glass and amount of alcohol poured: comparative study of effect of practice and concentration. BMJ, 331(7531), 1512-1514. DOI: 10.1136/bmj.331.7531.1512
Brian Wansink and Koert van Ittersum. (2006) The Visual Illusions of Food: Why Plates, Bowls, and Spoons Can Bias Consumption Volum. The FASEB Journal. info:/
Moseley GL, Olthof N, Venema A, Don S, Wijers M, Gallace A, & Spence C. (2008) Psychologically induced cooling of a specific body part caused by the illusory ownership of an artificial counterpart. Proceedings of the National Academy of Sciences of the United States of America, 105(35), 13169-73. PMID: 18725630
Moseley GL, Parsons TJ, & Spence C. (2008) Visual distortion of a limb modulates the pain and swelling evoked by movement. Current biology : CB, 18(22). PMID: 19036329
For those of you that may not be able to guess it from reading my blog – here’s a little factiod: I love, rather LOVE, biology. I’m often daydreaming about various organisms or landscapes – thinking about what it would be like to investigate certain phenomena. It would be nice [...]... Read more »
Zhu, B., Pan, K., & Wang, G. (2011) Effects of host starvation on the symbiotic dinoflagellates from the sea anemone Stichodactyla mertensii. Marine Ecology, 32(1), 15-23. DOI: 10.1111/j.1439-0485.2010.00405.x
Portnova, D., Mokievsky, V., & Soltwedel, T. (2011) Nematode species distribution patterns at the Håkon Mosby Mud Volcano (Norwegian Sea). Marine Ecology, 32(1), 24-41. DOI: 10.1111/j.1439-0485.2010.00403.x
Lazar, B., Gračan, R., Katić, J., Zavodnik, D., Jaklin, A., & Tvrtković, N. (2011) Loggerhead sea turtles (Caretta caretta) as bioturbators in neritic habitats: an insight through the analysis of benthic molluscs in the diet. Marine Ecology, 32(1), 65-74. DOI: 10.1111/j.1439-0485.2010.00402.x
I share an office with an Emeritus Professor of Orthopaedic Surgery. He snorted at me one day, and showed me the stats from our national joint register database where I saw that while the main reason given for revision of a total hip joint was dislocation, and pain was the sixth most common reason given; … Read more... Read more »
Jeffery, A., Wylde, V., Blom, A., & Horwood, J. (2011) “It's there and I'm stuck with it”: Patients' experiences of chronic pain following total knee replacement surgery. Arthritis Care , 63(2), 286-292. DOI: 10.1002/acr.20360
A genetic mistake that arose thousands of years ago spares rare HIV-infected individuals the ravages of AIDS. Researchers at Penn’s School of Medicine are in the midst of translating the language of ancient genetic mistakes into today’s cures.... Read more »
DORANZ, B. (1996) A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the ?-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors. Cell, 85(7), 1149-1158. DOI: 10.1016/S0092-8674(00)81314-8
Perez, E., Wang, J., Miller, J., Jouvenot, Y., Kim, K., Liu, O., Wang, N., Lee, G., Bartsevich, V., Lee, Y.... (2008) Establishment of HIV-1 resistance in CD4 T cells by genome editing using zinc-finger nucleases. Nature Biotechnology, 26(7), 808-816. DOI: 10.1038/nbt1410
2011 may be the year where the last known officially acknowledged stocks of the deadly smallpox virus, variola are destroyed - a virus that claimed over 500 million lives in the 20th century alone. The extensive collection of 'live' virus and DNA stocks totalling over 500 isolates/strains, which are held between the US Centres for Disease Control and the Russian State Research Centre of Virology and Biotechnology may be ordered to be eliminated following World Health Organisation (WHO) recommend........ Read more »
Gubser C, & Smith GL. (2002) The sequence of camelpox virus shows it is most closely related to variola virus, the cause of smallpox. The Journal of general virology, 83(Pt 4), 855-72. PMID: 11907336
Li, Y., Carroll, D., Gardner, S., Walsh, M., Vitalis, E., & Damon, I. (2007) From the Cover: On the origin of smallpox: Correlating variola phylogenics with historical smallpox records. Proceedings of the National Academy of Sciences, 104(40), 15787-15792. DOI: 10.1073/pnas.0609268104
Raymond S. Weinstein. (2011) Should Remaining Stockpiles of Smallpox Virus (Variola) Be Destroyed?. Emerg Infect Dis, 17(Apr). info:/10.3201/eid1704.101865
Rimoin AW, Mulembakani PM, Johnston SC, Lloyd Smith JO, Kisalu NK, Kinkela TL, Blumberg S, Thomassen HA, Pike BL, Fair JN.... (2010) Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proceedings of the National Academy of Sciences of the United States of America, 107(37), 16262-7. PMID: 20805472
You might think that a smartphone is a smartphone the world over or that perceptions of tablet PCs are the same from nation to nation. Internationally, speaking, isn’t a laptop still a laptop regardless of location? A new study by researchers in the US and India suggests otherwise. The authors of the study suggest that [...]Post from: David Bradley's Sciencetext Tech TalkTechnology with attitude
... Read more »
Kallol Bagchi, Purnendu Mandal, & Arunabha Mukhopadhyay. (2011) Attitude towards technology development: a cross-cultural study of India and the USA. Int. J. Information Systems and Change Management, 5(1), 3-21. info:/
by Lorna Powell in Elements Science
Lorna Powell tunes into new research that suggests our genes could influence our enjoyment of music.
Related posts:Lung cancer gene means risk for non-smokers too
Whose gene is it anyway?
Smoking can be good for you
... Read more »
Ukkola-Vuoti, L., Oikkonen, J., Onkamo, P., Karma, K., Raijas, P., & Järvelä, I. (2011) Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music. Journal of Human Genetics. DOI: 10.1038/jhg.2011.13
Deutsch, D., Henthorn, T., Marvin, E., & Xu, H. (2006) Absolute pitch among American and Chinese conservatory students: Prevalence differences, and evidence for a speech-related critical period. The Journal of the Acoustical Society of America, 119(2), 719. DOI: 10.1121/1.2151799
do_sud_thumb("http://neurobonkers.com/wp-content/uploads/2011/03/computer-doctor.jpg","One Nanostep for Technology, One... Read more »
Khodayari-Rostamabad A, Reilly JP, Hasey G, Debruin H, & Maccrimmon D. (2010) Diagnosis of psychiatric disorders using EEG data and employing a statistical decision model. Conference proceedings : .. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 4006-9. PMID: 21097280
Khodayari-Rostamabad, A., Hasey, G., MacCrimmon, D., Reilly, J., & Bruin, H. (2010) A pilot study to determine whether machine learning methodologies using pre-treatment electroencephalography can predict the symptomatic response to clozapine therapy. Clinical Neurophysiology, 121(12), 1998-2006. DOI: 10.1016/j.clinph.2010.05.009
Charles DeBattista, Gustavo Kinrys, Daniel Hoffman, Corey Goldstein, John Zajecka, James Kocsis, Martin Teicher, Steven Potkin, Adrian Preda, Gurmeet Multani, Len Brandt, Mark Schiller, Dan Iosifescu, Maurizio Fava. (2011) The use of referenced-EEG (rEEG) in assisting medication selection for the treatment of depression . Psychiatric Research, 15(12), 64-75. DOI: The use of referenced-EEG (rEEG) in assisting medication selection for the treatment of depression
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.