Is autism more common in Silicon Valley?A new study from Simon Baron-Cohen and colleagues asked pretty much this question, although rather than California, they looked at Eindhoven in Holland. Eindhoven is the tech hub of the Netherlands:This region contains the Eindhoven University of Technology, as well as the High Tech Campus Eindhoven, where IT and technology companies such as Philips, ASML, IBM and ATOS Origin are based... 30% of jobs in Eindhoven are now in technology or ICT, in Haarlem an........ Read more »
Roelfsema MT, Hoekstra RA, Allison C, Wheelwright S, Brayne C, Matthews FE, & Baron-Cohen S. (2011) Are Autism Spectrum Conditions More Prevalent in an Information-Technology Region? A School-Based Study of Three Regions in the Netherlands. Journal of autism and developmental disorders. PMID: 21681590
Risks and benefits of a gun in the home From American Journal of Lifestyle Medicine Despite the fact that nearly one-third of American households have a firearm, studies show that having a gun in the home poses a household a greater health risk than a potential benefit. This study examined scientific research on both sides [...]... Read more »
More people are surviving cancer than ever before. Thanks to decades of research, survival from cancer has doubled in the last 40 years, giving thousands of people more time with their loved ones. But this progress simply wouldn’t have been possible without animal research. At Cancer Research UK, research using animals is an unavoidable part [...]... Read more »
Chinwalla, A., Cook, L., Delehaunty, K., Fewell, G., Fulton, L., Fulton, R., Graves, T., Hillier, L., Mardis, E., McPherson, J.... (2002) Initial sequencing and comparative analysis of the mouse genome. Nature, 420(6915), 520-562. DOI: 10.1038/nature01262
KÖHLER, G., & MILSTEIN, C. (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 256(5517), 495-497. DOI: 10.1038/256495a0
Gambacorti-Passerini C, Antolini L, Mahon FX, Guilhot F, Deininger M, Fava C, Nagler A, Della Casa CM, Morra E, Abruzzese E.... (2011) Multicenter independent assessment of outcomes in chronic myeloid leukemia patients treated with imatinib. Journal of the National Cancer Institute, 103(7), 553-61. PMID: 21422402
Druker, B., Tamura, S., Buchdunger, E., Ohno, S., Segal, G., Fanning, S., Zimmermann, J., & Lydon, N. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells. Nature Medicine, 2(5), 561-566. DOI: 10.1038/nm0596-561
Kerbl DC, McDougall EM, Clayman RV, & Mucksavage P. (2011) A history and evolution of laparoscopic nephrectomy: perspectives from the past and future directions in the surgical management of renal tumors. The Journal of urology, 185(3), 1150-4. PMID: 21255799
The Blue Brain Project at Lausanne, led by Henry Markram, is to my mind, the most interesting and promising meeting of computer science and neurobiology. They recently published a paper (see citation) on the connectivity in the newborn visual cortex. They showed that neurons in small groups were interconnected independent of experience and that the [...]... Read more »
Perin, R., Berger, T., & Markram, H. (2011) A synaptic organizing principle for cortical neuronal groups. Proceedings of the National Academy of Sciences, 108(13), 5419-5424. DOI: 10.1073/pnas.1016051108
Pottery is the most important type of artifact for archaeology in the Southwest. This is because the agricultural societies of the prehistoric Southwest made huge numbers of pots and often decorated them in distinctive ways that differed both from place to place and over time, often within quite short periods. With the precision available from [...]... Read more »
We usually think of farmers as sturdy, Midwestern types who raise their ruddy-cheeked children on a balanced diet of eggs, potatoes, and chores. A study from researchers at Emory University, though, suggests that our farming ancestors weren't the picture of health. When humans transitioned from hunting and gathering to farming and living in cities, the authors say, they became malnourished and more prone to disease. Oh, and they were shorter.Scientists use height as a rough yardstick of a popula........ Read more »
Mummert, A., Esche, E., Robinson, J., & Armelagos, G. (2011) Stature and robusticity during the agricultural transition: Evidence from the bioarchaeological record. Economics , 9(3), 284-301. DOI: 10.1016/j.ehb.2011.03.004
Earlier today WhySharksMatter and I had a little light-hearted smack talk about new-school (stable isotopes) vs. old-school (gastric lavage or straight-up dissection) methods of measuring the diet of sharks. These are the things you could be privy to if you were following me on that newfangled Twitter thing (at “press time” I only have 113 followers so there’s still room to get in on the ground floor). This coincided with/provided procrastination during one of my occasional l........ Read more »
Link, J., & Ford, M. (2006) Widespread and persistent increase of Ctenophora in the continental shelf ecosystem off NE USA. Marine Ecology Progress Series, 153-159. DOI: 10.3354/meps320153
Markaida, U., & Sosa-Nishizaki, O. (2010) Food and feeding habits of the blue shark Prionace glauca caught off Ensenada, Baja California, Mexico, with a review on its feeding. Journal of the Marine Biological Association of the United Kingdom, 90(05), 977-994. DOI: 10.1017/S0025315409991597
As I have mentioned before on this blog, the use of tools like CS-ROSETTA holds the promise of determining protein structures using only the chemical shifts of its backbone atoms. In addition to potentially making NOEs and RDCs redundant, this technology allows biologists to determine the conformations of minor members of the structural ensemble, which are very difficult to obtain using conventional approaches in population-dominated techniques like NMR and X-ray crystallography. There are two l........ Read more »
Hansen, D., Neudecker, P., Vallurupalli, P., Mulder, F., & Kay, L. (2010) Determination of Leu Side-Chain Conformations in Excited Protein States by NMR Relaxation Dispersion. Journal of the American Chemical Society, 132(1), 42-43. DOI: 10.1021/ja909294n
Hansen, D.F., Neudecker, P., & Kay, L.E. (2010) Determination of isoleucine side-chain conformations in ground and excited states of proteins from chemical shifts. Journal of the American Chemical Society, 7589-7591. DOI: 10.1021/ja102090z
Hansen, D.F., & Kay, L.E. (2011) Determining valine side-chain rotamer conformations in proteins from methyl 13C chemical shifts: application to the 360 kDa half-proteasome. Journal of the American Chemical Society, 133(21), 8272-8281. DOI: 10.1021/ja2014532
For one of the most impressive seagoing predators of all time, Kronosaurus queenslandicus did not receive a very auspicious introduction in the scientific literature. Today the creature’s name immediately conjures up the image of a massive marine reptile with a cavernous maw arrayed with big, conical teeth, but in 1924, when Kronosaurus received its formal [...]... Read more »
Kear, B. (2003) Cretaceous marine reptiles of Australia: a review of taxonomy and distribution. Cretaceous Research, 24(3), 277-303. DOI: 10.1016/S0195-6671(03)00046-6
So this week we’re also behind a paywall, I think. Someday I will have time to actually go looking for Peer Reviewed Monday articles that meet a set of standards, but right now we’re still in the “something I read in real life this week” phase. And this one was interesting – so far, when [...]... Read more »
Nicolaidou, I., Kyza, E., Terzian, F., Hadjichambis, A., & Kafouris, D. (2011) A framework for scaffolding students' assessment of the credibility of evidence. Journal of Research in Science Teaching. DOI: 10.1002/tea.20420
In the past few months, I’ve received the following e-mail (or some similar version) several times. Generally, the scene is set in Texas (Coleman), but recently the location was switched to Georgia (Ohoopee River, Vidalia, or Lyons).
“We have killed 57 rattlesnakes on two separate ranches this year. 24 @South bend & 33 @ Murray , since mid May. Not one has buzzed! We provoked one fair sized boy ... Read more »
Means, D., & Travis, J. (2007) Declines in Ravine-inhabiting Dusky Salamanders of the Southeastern US Coastal Plain. Southeastern Naturalist, 6(1), 83-96. DOI: 10.1656/1528-7092(2007)6[83:DIRDSO]2.0.CO;2
Jolley, D., Ditchkoff, S., Sparklin, B., Hanson, L., Mitchell, M., & Grand, J. (2010) Estimate of herpetofauna depredation by a population of wild pigs. Journal of Mammalogy, 91(2), 519-524. DOI: 10.1644/09-MAMM-A-129.1
Place, A., & Abramson, C. (2008) Habituation of the Rattle Response in Western Diamondback Rattlesnakes, Crotalus atrox. Copeia, 2008(4), 835-843. DOI: 10.1643/CE-06-246
Information, images and videos of Glaucus Atlanticus, a tiny but beautiful sea slug found in oceans all over the world. It is commonly known as sea swallow, blue glaucus, blue sea slug, blue sea dragon and blue ocean slug.... Read more »
Carol M. Lalli, W. Gilmer. (1989) Pelagic snails: the biology of holoplanktonic gastropod mollusks. Choice Reviews Online, 27(01), 27-27. DOI: 10.5860/CHOICE.27-0306
MILLER, M. (1974) Aeolid nudibranchs (Gastropoda: Opisthobranchia) of the family Glaucidae from New Zealand waters. Zoological Journal of the Linnean Society, 54(1), 31-61. DOI: 10.1111/j.1096-3642.1974.tb00792.x
Social hierarchies are quite complicated. In the animal world hierarchies are wildly different based on social contexts, species, and environmental factors. For some animals, such as bull elephant seals, hierarchies are unstable—individuals spend a relatively short times at the top of the food chain—and what these alpha males get in terms of mating preferences, they pay dearly for in terms of physical fighting, aggressive confrontation, and threats from other male rivals. In unstable hierarc........ Read more »
Sapolsky, R. (2005) The Influence of Social Hierarchy on Primate Health. Science, 308(5722), 648-652. DOI: 10.1126/science.1106477
Adler, N., Boyce, T., Chesney, M., Cohen, S., & et al, . (1994) Socioeconomic status and health: The challenge of the gradient. American Psychologist, 49(1), 15-24. DOI: 10.1037//0003-066X.49.1.15
This article presents a comprehensive practice oriented framework for managing supply chain disruptions by Sunil Chopra and ManMohan S. Sodhi. The article has been published in the MIT Sloan Management Review in 2004. The framework covers everything from risk analysis to the selection of the risk mitigation strategy.
Chopra and Sodhi find nine categories for risk in the supply chain context. In figure 1 they contrast the risks with the corresponding risk drivers.
Figur........ Read more »
Chopra, S., & Sodhi, M.S. (2004) Managing Risk To Avoid Supply-Chain Breakdown. MIT Sloan Management Review, 46(1), 53-61. info:/
There's something they don't tell you about freelance writing. It's about all the fails: the many, many projects that get pitched, worked on and made into proper presentations that then get sent to book fairs, interested companies and so on, but ultimately explode on the launch pad, or die a slow, lingering death. I don't know if it's that I'm especially unlucky, or if it's that I've pitched an unusually high number of books, or if it's that I've genuinely worked on a high number of projects tha........ Read more »
Norberg, R. (1977) Occurrence and Independent Evolution of Bilateral Ear Asymmetry in Owls and Implications on Owl Taxonomy. Philosophical Transactions of the Royal Society B: Biological Sciences, 280(973), 375-408. DOI: 10.1098/rstb.1977.0116
If going on a diet or starting an exercise program resulted in persistent weight loss, we would not have an obesity epidemic.
Unfortunately, as anyone who has tried this knows, maintaining a significant degree of weight loss requires daily dedication, motivation and a limitless supply of will power - nothing short of developing a compulsive obsession.
As [...]... Read more »
Maclean PS, Bergouignan A, Cornier MA, & Jackman MR. (2011) Biology's Response to Dieting: the Impetus for Weight Regain. American journal of physiology. Regulatory, integrative and comparative physiology. PMID: 21677272
The 3D spatial arrangement of DNA within the nucleus is tightly controlled and has great functional significance. Each chromosome has been shown to occupy a defined nuclear territory and the expression of genes is often closely linked to where they are located, with similar expression levels seen for genes with similar locations. It has also been shown that disrupting localisation affects gene regulation.
... Read more »
Splinter E, de Wit E, Nora EP, Klous P, van de Werken HJ, Zhu Y, Kaaij LJ, van Ijcken W, Gribnau J, Heard E.... (2011) The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA. Genes . PMID: 21690198
Since 2000, there has been a massive flow of funding from the West into health care in developing African countries. Some of this has come from governmental sources in response to G8 initiatives such as the 2000 Millenium Fund and a significant amount has come from charitable organizations. One of the largest of these, the Bill [...]... Read more »
Kickbusch, I. (2004) From charity to rights: proposal for five action areas of global health. Journal of Epidemiology , 58(8), 630-631. DOI: 10.1136/jech.2004.021121
Muntaner C, Sridharan S, Solar O, & Benach J. (2009) Against unjust global distribution of power and money: the report of the WHO commission on the social determinants of health: global inequality and the future of public health policy. Journal of public health policy, 30(2), 163-75. PMID: 19597448
Last week’s post on FGFR1 mutations in squamous cell lung cancer and the new EGFR/ALK combination agent, AP26113 (Ariad) drew a lot of attention from readers, with many writing in for more details or correctly suggesting an update in squamous … Continue reading →
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Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou SH, Dezube BJ, Jänne PA, Costa DB.... (2010) Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. The New England journal of medicine, 363(18), 1693-703. PMID: 20979469
Wallowing in the bath, immersed in soothing warm water, the benefits are more than sensuous, they're social too. That's according to John Bargh and Idit Shalev, researchers at Yale University, whose new research shows that physical warmth can compensate for social isolation. Indeed, their study suggests that people subconsciously self-comfort against loneliness through the use of warm baths and showers.
Among 51 undergrads, those who reported being more lonely also tended to bath or shower more........ Read more »
J Bargh, & I Shalev. (2011) The substitutability of physical and social warmth in daily life. Emotion. DOI: 10.1037/a0023527
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