Post List

  • December 9, 2010
  • 05:34 PM

ADHD and High School Academics

by William Yates, M.D. in Brain Posts

Assessing the impact of a diagnosis of ADHD on school performance is a research challenge.  Many children and adolescents have a concurrent psychiatric disorder that can also impair learning.  Concurrent mental disorders found at higher rates for children with ADHD include (but are not limited to):Oppositional defiant disorderConduct disorderAnxiety disorderAutism spectrum disorderReading disorder or other learning disorderSo when designing research experiments to examine the academic ........ Read more »

Kent KM, Pelham WE Jr, Molina BS, Sibley MH, Waschbusch DA, Yu J, Gnagy EM, Biswas A, Babinski DE, & Karch KM. (2010) The Academic Experience of Male High School Students with ADHD. Journal of abnormal child psychology. PMID: 21103923  

  • December 9, 2010
  • 05:17 PM

Will Calgary’s new mayor succeed where Obama has failed?

by Christopher Leo in Christopher Leo

Calgary's new mayor, Naheed Nenshi, like Barack Obama, staged an upset victory with the help of social networking. Will he, unlike Obama, succeed in changing the political game? Continue reading →... Read more »

  • December 9, 2010
  • 04:49 PM

Zoledronic acid did not improve disease free survival in early breast cancer

by Sally Church in Pharma Strategy Blog

Wow, every now and then, something unexpected turns up and makes you stop, listen and most importantly, think.  This was the headline from an American Association of Clinical Research (AACR) news release that I received from the San Antonio Breast … Continue reading →... Read more »

Gnant, M., Mlineritsch, B., Schippinger, W., Luschin-Ebengreuth, G., Pöstlberger, S., Menzel, C., Jakesz, R., Seifert, M., Hubalek, M., Bjelic-Radisic, V.... (2009) Endocrine Therapy plus Zoledronic Acid in Premenopausal Breast Cancer. New England Journal of Medicine, 360(7), 679-691. DOI: 10.1056/NEJMoa0806285  

  • December 9, 2010
  • 04:27 PM

Pregnant and high: new treatments?

by PalMD in White Coat Underground

Many years ago a woman came to OB triage at my hospital.  She was about 28 weeks pregnant and feeling horrible.   As the nurses hooked her up to monitors and started an IV, she clutched a pink, kidney-shaped emesis basin, her boyfriend holding her hair back and away.  A few minutes later, she called [...]... Read more »

Jones, H., Kaltenbach, K., Heil, S., Stine, S., Coyle, M., Arria, A., O'Grady, K., Selby, P., Martin, P., & Fischer, G. (2010) Neonatal Abstinence Syndrome after Methadone or Buprenorphine Exposure. New England Journal of Medicine, 363(24), 2320-2331. DOI: 10.1056/NEJMoa1005359  

  • December 9, 2010
  • 03:32 PM

Fish Have Feelings (And They Can Be Seen In Their DNA)

by Christie Wilcox in Observations of a Nerd

Most animals reproduce sexually. This means that every individual has to find another individual to mate with - and they have to convince that other that they're worthy of the privilege. More often than not when it comes to picking that special someone, it's the girls that get to be choosy. Females spend a lot more energy per offspring than males from the get-go due to the size of our eggs (let alone most child rearing responsibilities), so as a gender, females want to make sure they don't waste........ Read more »

Desjardins, J., Klausner, J., & Fernald, R. (2010) Female genomic response to mate information. Proceedings of the National Academy of Sciences, 107(49), 21176-21180. DOI: 10.1073/pnas.1010442107  

  • December 9, 2010
  • 03:24 PM

Guest post - Microbes and Madness

by Lab Rat in Lab Rat

This guest post comes from my fiancé who is a Psychiatrist. I've been very excited about this post for a while, because unlike me, he is a published author who has written a book on Consciousness and the philosophy of mind.Microbes and MadnessAt first glance, it would be reasonable to assume that my profession and that of the author of this fabulous blog are poles apart. However, everything in nature has a connection, and so it is not surprising to discover a fascinating area where psychiatry a........ Read more »

Pfister D, Siegemund M, Dell-Kuster S, Smielewski P, Rüegg S, Strebel SP, Marsch SC, Pargger H, & Steiner LA. (2008) Cerebral perfusion in sepsis-associated delirium. Critical care (London, England), 12(3). PMID: 18457586  

  • December 9, 2010
  • 01:58 PM

A “Yes We Can” Approach to Overcoming Racism

by APS Daily Observations in Daily Observations

If you’re trying to put an end to racism, it’s not enough to get people to understand that racism is still a problem. You also have to make them feel ... Read more »

Stewart, T.L., Latu, I.M., Branscombe, N.R., & Denney, H.T. (2010) Yes we can!: prejudice reduction through seeing (inequality) and believing (in social change). Psychological science : a journal of the Association for Psychological Science/ APS, 21(11). PMID: 20889931  

  • December 9, 2010
  • 01:25 PM

Supply chain risk – it’s all in your head?

by Jan Husdal in

Enhancing supply chain resilience with flexibility and redundancy is one way to counter supply chain disruptions. But do the chosen resilience measures actually play a moderating role in reducing the frequency of supply chain disruptions? This article paints an interesting picture of how supply chain professionals view risk, which risk they perceive and what they do in reaction to these risks.... Read more »

Zsidisin, George, & Wagner, Stephan. (2010) Do Perceptions Become Reality? The Moderating Role of Supply Chain Resiliency on Disruption Occurrence . Journal of Business Logistics, 31(2), 1-20. info:other/

  • December 9, 2010
  • 01:04 PM

No Anomalous Enhancement of Nano-fluid Thermal Conductivity

by Arunn in nOnoScience (a.k.a. Unruled Notebook)

Nano was a buzz word a decade back in the USA. The buck was on anything prefixed with nano. Some useful technology did burgeon, identified now as nano-technology. Solar power, electronics and biotechnology were impacted with nano-engineered materials, capacitors and nano-probes and drug delivery methods. Chemistry and material science research in nano prospered with carbon [...]... Read more »

Buongiorno, J., Venerus, D., Prabhat, N., McKrell, T., Townsend, J., Christianson, R., Tolmachev, Y., Keblinski, P., Hu, L., Alvarado, J.... (2009) A benchmark study on the thermal conductivity of nanofluids. Journal of Applied Physics, 106(9), 94312. DOI: 10.1063/1.3245330  

  • December 9, 2010
  • 12:41 PM

Kissing the mistletoe goodbye?

by Sarah Stephen in Our Gossamer Planet

Kissing under the boughs of mistletoe is an oft-observed Christmas tradition, especially in the UK and the US. But, according to the UK’s National Trust, the years are fast approaching by when we may be kissing the UK mistletoe goodbye.The parasitic European Mistletoe, Viscum album, thrives on fruit trees such as the domestic apple tree and also other hosts such as lime, poplar, and hawthorn. Its heartland is the counties of Somerset, Gloucestershire, Herefordshire, and Worcestershire. How........ Read more »

  • December 9, 2010
  • 12:37 PM

New Mouse Model for Muscular Dystrophy

by Sanford- Burnham in Beaker

Roughly 50,000 people in the United States are affected by some type of muscular dystrophy, a condition characterized by debilitating muscle loss. Duchenne muscular dystrophy (DMD), the most common form of the disease, is caused by a mutation in the dystrophin gene. Without dystrophin, the interior muscle fiber frame can’t properly connect to the surrounding [...]... Read more »

Sacco A, Mourkioti F, Tran R, Choi J, Llewellyn M, Kraft P, Shkreli M, Delp S, Pomerantz JH, Artandi SE.... (2010) Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice. Cell. info:/10.1016/j.cell.2010.11.039

  • December 9, 2010
  • 12:16 PM

The neuroscientific study of hallucinogens

by Bradley Voytek in Oscillatory Thoughts

Recently, an important and landmark paper was published in PLoS ONE (hooray open access!) titled, "Investigating the Mechanisms of Hallucinogen-Induced Visions Using 3,4-Methylenedioxyamphetamine (MDA): A Randomized Controlled Trial in Humans". It sounds daunting, but trust me, it's a very cool, approachable study.Now, in the spirit of full-disclosure, the lead author Dr. Matthew Baggott (hereafter referred to as "Matt"), is a friend of mine from grad school and he's been kind enough to grant me........ Read more »

Voytek B, Berman SM, Hassid BD, Simon SL, Mandelkern MA, Brody AL, Monterosso J, Ling W, & London ED. (2005) Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusers. Synapse (New York, N.Y.), 57(2), 113-5. PMID: 15906384  

Berman SM, Voytek B, Mandelkern MA, Hassid BD, Isaacson A, Monterosso J, Miotto K, Ling W, & London ED. (2008) Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse. Molecular psychiatry, 13(9), 897-908. PMID: 17938635  

  • December 9, 2010
  • 11:59 AM

Risk of lung cancer after treatment for breast cancer

by Sally Church in Pharma Strategy Blog

There was an interesting paper published recently in The Lancet Oncology, which looked at the increased risk of developing lung cancer after women had experienced prior breast cancer (see ref below).  Over the years, there has been much debate about … Continue reading →... Read more »

Lorigan, P., Califano, R., Faivre-Finn, C., Howell, A., & Thatcher, N. (2010) Lung cancer after treatment for breast cancer. The Lancet Oncology, 11(12), 1184-1192. DOI: 10.1016/S1470-2045(10)70056-5  

  • December 9, 2010
  • 10:45 AM

The snowshoe hare-coyote-Dall's sheep cycle?

by TwoYaks in Gene Flow

When we teach our students predator-prey relationships, we tend to tell them a very basic story that have come from a few very good studies. It's not that all we have are simple models, but but we like to build up the basics before we dive into the complexities. Because when you get down to the complexities, a lot of counter-intuitive things happen which don't follow "common-sense" relationships.... Read more »

  • December 9, 2010
  • 09:19 AM

Foiling Fungal Forgery with French Fingerprinting Forensics

by avi_wener in The European Biotechnologist

The black truffle is a fungus that grows almost exclusively in Europe and has been termed “the diamond of the kitchen” by 18th-century French gastronome Brillat-Savarin (source: Wikipedia). Production has considerably diminished in the past century, and in accordance with the law of supply and demand, the price of the truffle has skyrocketed to approximately [...]... Read more »

Martin F, Kohler A, Murat C, Balestrini R, Coutinho PM, Jaillon O, Montanini B, Morin E, Noel B, Percudani R.... (2010) Périgord black truffle genome uncovers evolutionary origins and mechanisms of symbiosis. Nature, 464(7291), 1033-8. PMID: 20348908  

  • December 9, 2010
  • 07:30 AM

Good Idea, Bad Execution: Dosing Errors, A Preventable Harm

by Scott in Science-Based Pharmacy

Crossposted at Science-Based Medicine, today’s post expands on a prior SBP post. Our desire to practice in a science-based way can face many hurdles, and can even be thwarted at the last possible moment – in the form of dosing errors. The workup may have been comprehensive, the diagnosis could be correct, the most clinically [...]... Read more »

Yin HS, Mendelsohn AL, Wolf MS, Parker RM, Fierman A, van Schaick L, Bazan IS, Kline MD, & Dreyer BP. (2010) Parents' medication administration errors: role of dosing instruments and health literacy. Archives of pediatrics , 164(2), 181-6. PMID: 20124148  

  • December 9, 2010
  • 07:00 AM

Dying to Work Overtime

by Shaheen Lakhan in Brain Blogger

President Ronald Reagan once joked that hard work never killed anyone, but why take the chance? According to a new study, he may have been correct in avoiding burning the proverbial midnight oil. A study published in the European Heart Journal reports that working overtime is an independent risk factor for incident cardiovascular disease. Researchers [...]... Read more »

Lallukka T, Martikainen P, Reunanen A, Roos E, Sarlio-Lähteenkorva S, & Lahelma E. (2006) Associations between working conditions and angina pectoris symptoms among employed women. Psychosomatic medicine, 68(2), 348-54. PMID: 16554403  

Lallukka T, Sarlio-Lähteenkorva S, Roos E, Laaksonen M, Rahkonen O, & Lahelma E. (2004) Working conditions and health behaviours among employed women and men: the Helsinki Health Study. Preventive medicine, 38(1), 48-56. PMID: 14672641  

Schulte PA, Wagner GR, Ostry A, Blanciforti LA, Cutlip RG, Krajnak KM, Luster M, Munson AE, O'Callaghan JP, Parks CG.... (2007) Work, obesity, and occupational safety and health. American journal of public health, 97(3), 428-36. PMID: 17267711  

Steptoe A, Cropley M, & Joekes K. (1999) Job strain, blood pressure and response to uncontrollable stress. Journal of hypertension, 17(2), 193-200. PMID: 10067788  

Virtanen M, Ferrie JE, Singh-Manoux A, Shipley MJ, Vahtera J, Marmot MG, & Kivimäki M. (2010) Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study. European heart journal, 31(14), 1737-44. PMID: 20460389  

  • December 9, 2010
  • 07:00 AM

Good Idea, Bad Execution: Dosing Errors, A Preventable Harm

by Scott Gavura in Science-Based Medicine

We spend a lot time at SBM discussing different elements of the art and science of medicine, and how we believe that practice can be improve. Yet our science-based intentions can be thwarted at the last possible moment – in the form of dosing errors. The workup may have been comprehensive, the diagnosis could be [...]... Read more »

Yin HS, Mendelsohn AL, Wolf MS, Parker RM, Fierman A, van Schaick L, Bazan IS, Kline MD, & Dreyer BP. (2010) Parents' medication administration errors: role of dosing instruments and health literacy. Archives of pediatrics , 164(2), 181-6. PMID: 20124148  

  • December 9, 2010
  • 07:00 AM

Sedentary Physiology Part 4 – How Does Sitting Increase Health Risk?

by Travis Saunders, MSc, CEP in Obesity Panacea / CC BY 2.0

Welcome to our 5-part series delving into the fascinating research being performed in the emerging field of sedentary physiology.  In Part 1 we discussed the basics of sedentary physiology, in Part 2 we discussed the relationship between total sedentary time and negative health outcomes, and in Part 3 we examined how interruptions in sedentary time may be protective health benefits.  Today we look at the mechanisms underlying these relat........ Read more »

  • December 9, 2010
  • 07:00 AM

December 9, 2010

by Erin Campbell in HighMag Blog

Some of the most striking and informative images aren’t of cells or organisms, but are computer-generated representations of what is going on in cells or organisms. These computer-generated images come from the use of two-photon microscopy, a powerful technique that allows for imaging of tissue that’s buried deep in a living organism.... Read more »

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