So this week seems to be turning out to be cooperation week. We talked about cooperative behavior of the proteins that make up the cytoskeleton on Monday, cooperation in breeding behavior in birds on Wednesday, and now it’s time to talk about cooperative behavior in bacteria. If only I’d planned it in advance. Ah well; [...]... Read more »
An unusually gripping genetics paper from Biological Psychiatry: Pagnamenta et al.The authors discuss a family where two out of the three children were diagnosed with autism. In 2009, they detected a previously unknown copy number variant mutation in the two affected brothers: a 594 kb deletion knocking out two genes, called DOCK4 and IMMP2L.Yet this mutation was also carried by their non-autistic mother and sister, suggesting that it wasn't responsible for the autism. The mother's side of the f........ Read more »
Pagnamenta, A., Bacchelli, E., de Jonge, M., Mirza, G., Scerri, T., Minopoli, F., Chiocchetti, A., Ludwig, K., Hoffmann, P., & Paracchini, S. (2010) Characterization of a Family with Rare Deletions in CNTNAP5 and DOCK4 Suggests Novel Risk Loci for Autism and Dyslexia. Biological Psychiatry, 68(4), 320-328. DOI: 10.1016/j.biopsych.2010.02.002
Have you been in a situation where you are the first to detect a cardiac murmur in a patient? If you are hearing it in a busy, loud Emergency Department, I find that it's at least a grade III. Should you order an echocardiogram for further outpatient evaluation? It depends on the grade and characteristic of the murmur, in addition to the patient's symptoms. For instance, all diastolic murmurs require an echo. There is a useful ACC/AHA algorithm which helps you decide.Thanks to Amy Kinard, an Eme........ Read more »
, ., Bonow, R., Carabello, B., Chatterjee, K., de Leon, A., Faxon, D., Freed, M., Gaasch, W., Lytle, B., Nishimura, R.... (2008) 2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to. Circulation, 118(15). DOI: 10.1161/CIRCULATIONAHA.108.190748
Evolutionary Anthropology has a nice paper summarizing the history of domestic cattle, based on the latest molecular marker data. Unusually, the authors at least attempt a flowing account of the origin and spread of a domesticated species, and even more unusually actually achieve it in places. Alas, the details of haplogroups and mtDNA vs Y-chromosome [...]... Read more »
Ajmone-Marsan, P., Garcia, J., & Lenstra, J. (2010) On the origin of cattle: How aurochs became cattle and colonized the world. Evolutionary Anthropology: Issues, News, and Reviews, 19(4), 148-157. DOI: 10.1002/evan.20267
Reading the following passage might lead you to exclaim: “What an incredible storyteller J.R.R. Tolkien was!” or more likely, “What a visionary evolutionary biologist J.R.R. Tolkien was!” depending on how you interpret it of course. “He was Gollum—as dark as darkness, except for two big round pale eyes in his thin face. He had a [...]... Read more »
Yoshizawa M, Gorički S, Soares D, & Jeffery WR. (2010) Evolution of a Behavioral Shift Mediated by Superficial Neuromasts Helps Cavefish Find Food in Darkness. Current biology : CB. PMID: 20705469
[Wherein our hero examines the influence of colour on competitiveness for an upcoming tournament. Repost] I’ll need to provide a little context: For the last 10 or 11 years I have studies Taekwon-Do. No, no, not the stuff you see in the Olympics – but a real martial art, you know [where they use their hands [...]... Read more »
Frank, M., & Gilovich, T. (1988) The dark side of self- and social perception: Black uniforms and aggression in professional sports. Journal of Personality and Social Psychology, 54(1), 74-85. DOI: 10.1037/0022-35220.127.116.11
Hill, R., & Barton, R. (2005) Psychology: Red enhances human performance in contests. Nature, 435(7040), 293-293. DOI: 10.1038/435293a
It was a rare bit of good news. India’s Forest Ministry recently announced that the nation’s forests had expanded by nearly 5% over the last decade – an impressive gain in a country that had lost 80% of its native trees. But three researchers are now challenging that survey, saying it masked continuing forest losses […] Read More »... Read more »
Puyravaud, J., Davidar, P., & Laurance, W. (2010) POLICY PERSPECTIVE: Cryptic destruction of India's native forests. Conservation Letters. DOI: 10.1111/j.1755-263X.2010.00141.x
Most Nutritional Therapists are comfortable in the concept and application of concentrated essential fatty acids especially fish oils as a means of altering abnormal inflammatory pathways in the body. Some EFA’s are perceived to be anti-inflammatory and others pro-inflammatory. Whilst the simplistic dichotomy of interpretation (Omega 3 Anti/Omega 6 Pro) has kept many a student [...]... Read more »
Oh da Y, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, & Olefsky JM. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell, 142(5), 687-98. PMID: 20813258
Schenk, S., Saberi, M., & Olefsky, J. (2008) Insulin sensitivity: modulation by nutrients and inflammation. Journal of Clinical Investigation, 118(9), 2992-3002. DOI: 10.1172/JCI34260
Ford, E. (2002) Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey. JAMA: The Journal of the American Medical Association, 287(3), 356-359. DOI: 10.1001/jama.287.3.356
This definition of supply risk views the supply chain from end to end, acknowledging that what you purchase as a supply, in the the end will wind up in some customer's hand, to which you may be liable, if your product or service is faulty [ ... ]... Read more »
A new study identifies a likely cause of rapid degeneration in some Alzheimer's patients. The results of this study may lead to improved treatment.
But first, let's look at the method used in this study, because that may be almost as important as a development. And for this, we will use a sports analogy. Read the rest of this post... | Read the comments on this post...... Read more »
Cruchaga, Carlos, Kauwe, John, Mayo, Kevin, Spiegel, Noah, Bertelsen, Sarah, & Et.Al. (2010) SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer’s Disease . PLoS Genetics, 6(9). info:/
Subliminal priming is a cool psychological trick that can change the way you think or the things you do without you even being aware of it. So, for example, you do a word puzzle that includes religious words, and chances are you'll behave more honestly later.
Which brings us to the Golden Rule. This is one of those basic components of human morality that pops up in pretty much every culture - the British Humanist Society even produces a poster with 20 different versions from around the world. T........ Read more »
Vilaythong T., O., Lindner, N., & Nosek, B. (2010) “Do Unto Others”: Effects of Priming the Golden Rule on Buddhists’ and Christians’ Attitudes Toward Gay People. Journal for the Scientific Study of Religion, 49(3), 494-506. DOI: 10.1111/j.1468-5906.2010.01524.x
by John M Grohol PsyD in World of Psychology - Psych Central
We’ve all been there — sitting in a public place, and feeling like that person over there, talking on their cell phone, is so annoying. Why are they so annoying? What makes a cell phone conversation that you overhear so distracting?
Four researchers, led by Lauren Emberson (2010) from Cornell University, set to find out.
Previous research has shown that we don’t seem to be as distracted when listening to a full dialogue between two people as when we are listening to a “h........ Read more »
Emberson LL, Lupyan G, Goldstein MH, & Spivey MJ. (2010) Overheard Cell-Phone Conversations: When Less Speech Is More Distracting. Psychological science : a journal of the American Psychological Society / APS. PMID: 20817912
The tumor suppressor p53 is one of the cell’s very best friends. Just how good a friend it is becomes apparent when, just like in other relationships, this particular relationship turns sour. p53 is the “master guardian angel” of the genome and constitutes the most frequent genetic alteration in cancer. More than 50% of human tumors contain a mutation in the p53 gene. With this kind of glowing track record, p53 would be a prime target for drugs.It turns out that discovering drugs for p53 i........ Read more »
Basse, N., Kaar, J., Settanni, G., Joerger, A., Rutherford, T., & Fersht, A. (2010) Toward the Rational Design of p53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chemistry , 17(1), 46-56. DOI: 10.1016/j.chembiol.2009.12.011
Objective 1: Develop the least publicly accessible title for a blog post about seadragons, mate selection, and evolution
Objective 1 Status: complete
Objective 2: Draw in whatever readers push passed the unwieldy title with an unconventional narrative structure.
Objective 2 Status: complete
Objective 3: Hook the reader with a fascinating, though brief, background on seahorses, seadragons, and pipefish.
Female [...]... Read more »
Wilson, N., & Rouse, G. (2010) Convergent camouflage and the non-monophyly of ‘seadragons’ (Syngnathidae: Teleostei): suggestions for a revised taxonomy of syngnathids. Zoologica Scripta. DOI: 10.1111/j.1463-6409.2010.00449.x
I found a new paper in my reader this morning from the crew who published the first description and taxonomic statements about Darwinius massillae, Phillip Gingerich and his colleagues. This paper is a reply to Williams et al. (2010), which … Continue reading →... Read more »
Gingerich, P., Franzen, J., Habersetzer, J., Hurum, J., & Smith, B. (2010) Darwinius masillae is a Haplorhine — Reply to Williams et al. (2010). Journal of Human Evolution. DOI: 10.1016/j.jhevol.2010.07.013
Williams, B., Kay, R., Christopher Kirk, E., & Ross, C. (2010) Darwinius masillae is a strepsirrhine—a reply to Franzen et al. (2009). Journal of Human Evolution. DOI: 10.1016/j.jhevol.2010.01.003
Seiffert, E., Perry, J., Simons, E., & Boyer, D. (2009) Convergent evolution of anthropoid-like adaptations in Eocene adapiform primates. Nature, 461(7267), 1118-1121. DOI: 10.1038/nature08429
by Mary in OpenHelix
This week I was working on finishing up some training materials on the ENCODE data. We’ve talked about this before, and we’ve had some materials out already to support the ENCODE project, since we have a contract with the folks at UCSC to do some training on it. (The new materials should be out later [...]... Read more »
Schnoes, A., Brown, S., Dodevski, I., & Babbitt, P. (2009) Annotation Error in Public Databases: Misannotation of Molecular Function in Enzyme Superfamilies. PLoS Computational Biology, 5(12). DOI: 10.1371/journal.pcbi.1000605
Rosenbloom, K., Dreszer, T., Pheasant, M., Barber, G., Meyer, L., Pohl, A., Raney, B., Wang, T., Hinrichs, A., Zweig, A.... (2009) ENCODE whole-genome data in the UCSC Genome Browser. Nucleic Acids Research, 38(Database). DOI: 10.1093/nar/gkp961
Harold Garner (Virginia Bioinformatics Institute, United States) and coworkers have improved upon the eTBLAST tool for uncovering plagiarism in the technical science literature. This news feature was written on September 16, 2010.... Read more »
Sun, Z., Errami, M., Long, T., Renard, C., Choradia, N., & Garner, H. (2010) Systematic Characterizations of Text Similarity in Full Text Biomedical Publications. PLoS ONE, 5(9). DOI: 10.1371/journal.pone.0012704
Storage room, garage, attic, boxes, under the bed, dorm room... Whatever we choose to call it it, we all have our secret stashes of mess. Imagine the last time you were forced to confront your secret mess pile (if you are anything like me, this is still in short-term memory) to find your blue shirt amongst the heaps of cell phone chargers, clothes, and other notebooks. A few days later, you have to re-confront the mass to find a few AA batteries. Do you have any chance?... Read more »
Just before the American Society of Hematology (ASH) meeting last December, I posted an overview of the JAK2 pathway and pipeline inhibitors in development. Things have changed a bit since then, with TargeGen's inhibitor, TG101348, being licensed by sanofi-aventis and...... Read more »
Vannucchi, A. (2010) From Palliation to Targeted Therapy in Myelofibrosis. New England Journal of Medicine, 363(12), 1180-1182. DOI: 10.1056/NEJMe1005856
Verstovsek, S., Kantarjian, H., Mesa, R., Pardanani, A., Cortes-Franco, J., Thomas, D., Estrov, Z., Fridman, J., Bradley, E., Erickson-Viitanen, S.... (2010) Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis. New England Journal of Medicine, 363(12), 1117-1127. DOI: 10.1056/NEJMoa1002028
Anderson (2010) discovers that cheating men crave ‘emotional monogamy’ with their partners and to have their physical desires fulfilled through multiple, additional sexual contacts. Many such men claim to love their partners even more because they cheat on them.
... Read more »
Anderson, E. (2010) 'At Least With Cheating There is an Attempt at Monogamy': Cheating and Monogamism Among Undergraduate Heterosexual Men. Journal of Social and Personal Relationships. info:/
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