Post List

  • August 15, 2011
  • 07:00 AM

August 15, 2011

by Erin Campbell in HighMag Blog

You may live in many places throughout your life, but you have only one hometown. No matter what, your core is deeply affected by where you grew up (for me, that core is made of a fondness for fries covered with gravy, impassioned shouts of Bruuuuuce, and traumatic experiences with a teasing comb and hairspray…yes, that’s New Jersey). Just like us, a tumor is affected by its origin…its growth, malignancy, and responsiveness to treatment are all dependent on where the cancer cells came fr........ Read more »

Liu, C., Sage, J., Miller, M., Verhaak, R., Hippenmeyer, S., Vogel, H., Foreman, O., Bronson, R., Nishiyama, A., Luo, L.... (2011) Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma. Cell, 146(2), 209-221. DOI: 10.1016/j.cell.2011.06.014  

  • August 15, 2011
  • 06:00 AM

The worm turns – a new amino acid

by Suzanne Elvidge in Genome Engineering

There are 20 amino acids found in nature, but scientists have engineered a nematode worm to create a 21st – an entirely artificial amino acid.... Read more »

Greiss S, & Chin JW. (2011) Expanding the Genetic Code of an Animal. Journal of the American Chemical Society. PMID: 21819153  

  • August 15, 2011
  • 04:42 AM

Wikipedia: I Fought the Lore and the Lore Won

by Duncan Hull in O'Really?

Fighting the lore of wikipedia is an increasingly futile battle but there are people who resist using and improving the online encyclopedia. The remarkable thing is that some of this resistance comes from the scientific and academic communities, two groups of people who are supposedly concerned with the dissemination of knowledge. Wikipedia is the lore With [...]... Read more »

Neil L. Waters. (2007) Why you can't cite Wikipedia in my class. Communications of the ACM, 15-17. DOI: 10.1145/1284621.1284635  

Patricia L. Dooley. (2010) Wikipedia and the two-faced professoriate. WikiSym '10 Proceedings of the 6th International Symposium on Wikis and Open Collaboration. DOI: 10.1145/1832772.1832803  

Logan DW, Sandal M, Gardner PP, Manske M, & Bateman A. (2010) Ten simple rules for editing Wikipedia. PLoS computational biology, 6(9). PMID: 20941386  

  • August 15, 2011
  • 03:22 AM

A Ghostwriter Speaks

by Neuroskeptic in Neuroskeptic

PLoS ONE offers the confessions of a former medical ghostwriter: Being the Ghost in the Machine.

The article (which is open access and short, so well worth a read) explains how Linda Logdberg became a medical writer; what excited her about the job; what she actually did; and what made her eventually give it up.

Ghostwriting of course has a bad press at the moment and it's recently been banned by some leading research centres. Ghostwriting certainly is concerning, because of what it implies ab........ Read more »

  • August 15, 2011
  • 01:36 AM

Internet Addiction Treatment, A Systematic Review

by Dr Shock in Dr Shock MD PhD

Buffer In previous posts I already expressed my doubt about this phenomenon: Internet Addiction. The biggest problem with studies defining a new syndrome is usually that they don’t use validated diagnostic tools but mostly some severity scale. Internet Addiction is not clearly defined in the recent scientific publications and research. Some researchers have adapted substance use [...]

No related posts.... Read more »

  • August 15, 2011
  • 12:13 AM

Combination of Product and Supply Chain Design

by Daniel Dumke in SCRM Blog - Supply Chain Risk Management

In research the decisions on the product and the corresponding supply chain are usually separated. This happens for a variety of reasons, one may be the reduction of problem complexity, another that the research focus is on a brown field approach where the products are seen as given.... Read more »

  • August 15, 2011
  • 12:13 AM

Scent of a Woman

by Krystal D'Costa in Anthropology in Practice

At seventeen I discovered the perfume that would become my signature scent. It’s a warm, rich, inviting fragrance[i] that reminds me (and hopefully others) of a rose garden in full bloom. Despite this fullness, it’s light enough to wear all day and it’s been in the background of many of my life experiences. It announces [...]

... Read more »

  • August 14, 2011
  • 10:47 PM

One way traffic

by Vivek Venkataraman in sciencebyte

Realization of an optical diode... Read more »

Feng, L., Ayache, M., Huang, J., Xu, Y., Lu, M., Chen, Y., Fainman, Y., & Scherer, A. (2011) Nonreciprocal Light Propagation in a Silicon Photonic Circuit. Science, 333(6043), 729-733. DOI: 10.1126/science.1206038  

  • August 14, 2011
  • 10:46 PM

Kim's the name

by Vivek Venkataraman in sciencebyte

Statistical study of the distribution of Korean family names... Read more »

Baek, S., Minnhagen, P., & Kim, B. (2011) The ten thousand Kims. New Journal of Physics, 13(7), 73036. DOI: 10.1088/1367-2630/13/7/073036  

  • August 14, 2011
  • 10:44 PM

Immune Activation/Inflammation and HIV Disease: an expanded summary of the IAS 2011 symposium

by Jennifer Ring in Antiviral Immunity

A summary of the IAS Immune Activation/Inflammation and HIV Disease Symposium... Read more »

Brenchley, J., Price, D., Schacker, T., Asher, T., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D.... (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Medicine, 12(12), 1365-1371. DOI: 10.1038/nm1511  

Chang, J., & Altfeld, M. (2008) TLR-mediated immune activation in HIV. Blood, 113(2), 269-270. DOI: 10.1182/blood-2008-10-184598  

J Buzón, M., Massanella, M., Llibre, J., Esteve, A., Dahl, V., Puertas, M., Gatell, J., Domingo, P., Paredes, R., Sharkey, M.... (2010) HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects. Nature Medicine, 16(4), 460-465. DOI: 10.1038/nm.2111  

Mehandru S, Poles MA, Tenner-Racz K, Jean-Pierre P, Manuelli V, Lopez P, Shet A, Low A, Mohri H, Boden D.... (2006) Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection. PLoS medicine, 3(12). PMID: 17147468  

Kelley CF, Kitchen CM, Hunt PW, Rodriguez B, Hecht FM, Kitahata M, Crane HM, Willig J, Mugavero M, Saag M.... (2009) Incomplete peripheral CD4 cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 48(6), 787-94. PMID: 19193107  

Schacker, T., Brenchley, J., Beilman, G., Reilly, C., Pambuccian, S., Taylor, J., Skarda, D., Larson, M., Douek, D., & Haase, A. (2006) Lymphatic Tissue Fibrosis Is Associated with Reduced Numbers of Naive CD4 T Cells in Human Immunodeficiency Virus Type 1 Infection. Clinical and Vaccine Immunology, 13(5), 556-560. DOI: 10.1128/CVI.13.5.556-560.2006  

Zeng M, Smith AJ, Wietgrefe SW, Southern PJ, Schacker TW, Reilly CS, Estes JD, Burton GF, Silvestri G, Lifson JD.... (2011) Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. The Journal of clinical investigation, 121(3), 998-1008. PMID: 21393864  

Ouchi N, Parker JL, Lugus JJ, & Walsh K. (2011) Adipokines in inflammation and metabolic disease. Nature reviews. Immunology, 11(2), 85-97. PMID: 21252989  

Sereti I, Anthony KB, Martinez-Wilson H, Lempicki R, Adelsberger J, Metcalf JA, Hallahan CW, Follmann D, Davey RT, Kovacs JA.... (2004) IL-2-induced CD4 T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation. Blood, 104(3), 775-80. PMID: 15090457  

Abrams D. (2009) Interleukin-2 Therapy in Patients with HIV Infection. New England Journal of Medicine, 361(16), 1548-1559. DOI: 10.1056/NEJMoa0903175  

  • August 14, 2011
  • 09:00 PM

Hold the Starch?

by Aurametrix team in Irritable Bowel Blog

Starch is that stuff that stiffens your shirts. It's also what most people eat for fuel. Wheat, rice, corn, oats, potatoes are all very starchy foods. Many popular diet plans call starch a second-rate food that should be avoided at all costs. No-starch and low starch diets are favored by irritable bowel communities, while former Weight Watchers, Jenny Craig and Atkins enthusiasts love the new Carb Lovers Diet praising starch. Yet, there may be something good about starch even for those with........ Read more »

  • August 14, 2011
  • 08:00 PM

This Ain’t Yo Momma’s Muktuk: Fermented Seal Flipper, Botulism, Being Cold & Other Joys of Artic Living

by Rebecca Kreston in BODY HORRORS

Several cases of botulism in Alaskan Natives have occurred as a result of changing Alaskan Native methods of fermenting meat. Traditional food preparation and storage techniques of burying meat underground to ferment have since been modified by the introduction of Western conveniences; Tupperware containers and sealable plastic bags are now being used to create a meaty, anaerobic environment that C. botulinum is happy to vacation in. ... Read more »

  • August 14, 2011
  • 05:51 PM

Please Pass the Salt

by Cath in Basal Science (BS) Clarified

Do you feel like your grandfather adds more salt to his soup each time you see him? Turns out this is actually one of the physiological effects of aging. In fact, Stevens et al. [1] reported that the elder required twice as much salt as the young before detecting it in their tomato soup.... Read more »

  • August 14, 2011
  • 05:50 PM

The Wikipedia Gender Gap, Part III

by Hadas Shema in Information Culture

In part I and part II, we discussed several of the gender gaps in Wikipedia. In this part, we'll talk about reverted edits, blocking, and their association with female and male editors. .
Blocking The hypothesis here was that "Female editors are less likely to be blocked." However, there wasn't a statistically significant difference in the percentage of females blocked (4.39%) and males blocked (4.52%). Surprisingly, females were significantly more likely to be blocked indefinitely (3.85% and 3........ Read more »

Lam, S., Uduwage, A., Dong, Z., Sen, S., Musicant, D. R., Terveen, L., & Terveen, J. (2011) WP:Clubhouse? An Exploration of Wikipedia’s Gender Imbalance. WikiSym’11, October 3–5, Mountain View, California. info:/

  • August 14, 2011
  • 05:02 PM

What is a Mass Extinction?

by Marc in Teaching Biology

One of the main background themes in my history of life series was that extinctions will always happen – they’re a natural part of the biosphere’s evolution. But I never really explained what a mass extinction is. For example, the case of mayflies, who emerge as sexually mature adults simultaneously and live between a few [...]... Read more »

Bambach, R. (2006) PHANEROZOIC BIODIVERSITY MASS EXTINCTIONS. Annual Review of Earth and Planetary Sciences, 34(1), 127-155. DOI: 10.1146/  

  • August 14, 2011
  • 02:35 PM

Save your skin, but bend your bones?

by NerdyOne in Try Nerdy

Now that I’m back from visiting amusement parks in Orlando, FL, I think it’s as good a time as any to reveal a little secret of mine: I don’t wear sunscreen. (“Not even in Florida?!”) Not even in Florida. In August.

I want to be really emphatic in saying that I am NOT advocating for people to go without sunscreen. You have to do what works for you. I was raised in sunny places and I almost never get sunburns, and now that I live in New England I’m much more........ Read more »

Lowdon J. (2011) Rickets: concerns over the worldwide increase. The journal of family health care, 21(2), 25-9. PMID: 21678784  

  • August 14, 2011
  • 01:48 PM

Be Kind to Cattle

by Paul Norris in AnimalWise

In a more ideal world, cattle would be free to lead lives consistent with their ancestry as nomadic grazers covering wide ranges. Of course, this isn’t a perfect world, particularly for the cows and other farmyard animals … Continue reading →... Read more »

  • August 14, 2011
  • 01:39 PM

Molecular evolution of RSH proteins, lookouts and messengers of stress signals

by Gemma Atkinson in Protein evolution and other musings

A few days ago (the day before my 30th birthday actually), my most recent paper, along with Vasili Hauryliuk and Tanel Tenson, "The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life" was published with PloS ONE. Hurrah!The RSH proteins comprise a superfamily of enzymes that synthesize and/or hydrolyze the alarmone ppGpp. ppGpp is a nucleotide that acts as an alarm signal, activating the “stringent” response........ Read more »

Gemma C. Atkinson, Tanel Tenson, & Vasili Hauryliuk. (2011) The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life. PLoS ONE, 6(8). info:/

  • August 14, 2011
  • 11:30 AM

Neury Thursday: Little Exercise, Big [Neuroprotective] Effects

by Allison in Dormivigilia

Researchers at Boulder examined the neuroprotective benefits of exercise on infection- and aging-induced neuroinflammation, neural degenerative, and learning impairments. A win-win for physiological and behavioral systems. ... Read more »

Barrientos RM, Frank MG, Crysdale NY, Chapman TR, Ahrendsen JT, Day HE, Campeau S, Watkins LR, Patterson SL, & Maier SF. (2011) Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(32), 11578-86. PMID: 21832188  

  • August 14, 2011
  • 09:22 AM

On neural correlates and causation

by Jon Brock in Cracking the Enigma

The advent of neuroimaging techniques such as magnetic resonance imaging (MRI) has revolutionized autism research. We can now look into the brain and see the "neural correlates" of autism. But, as with any form of correlation, identifying a neural correlate doesn't necessarily mean that we have identified a neural cause.

A case in point. Earlier this week I stumbled across a press release doing the rounds of the internet, proclaiming that "Brain imaging research reveals why autistic indiv........ Read more »

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