This is the second instalment of “Proud & Majestic” but another title fit better and it stands proudly and majestically on it’s own. In this post, I want to tell you a story. Indeed, it is one of the best stories because it is true (and artistic licence is obvious and mine and mine alone). [...]... Read more »
Yeakel, J., Patterson, B., Fox-Dobbs, K., Okumura, M., Cerling, T., Moore, J., Koch, P., & Dominy, N. (2009) From the Cover: Cooperation and individuality among man-eating lions. Proceedings of the National Academy of Sciences, 106(45), 19040-19043. DOI: 10.1073/pnas.0905309106
Packer, C., Ikanda, D., Kissui, B., & Kushnir, H. (2005) Conservation biology: Lion attacks on humans in Tanzania. Nature, 436(7053), 927-928. DOI: 10.1038/436927a
Our bodies are made of millions upon millions of tiny cells. One of the biggest challenges for researchers studying cancer is to find out what individual cells are doing as they change from a healthy state to a cancerous one. But many lab techniques only give an overview of a large population of cells, either [...]... Read more »
Connelly, J., Gautrot, J., Trappmann, B., Tan, D., Donati, G., Huck, W., & Watt, F. (2010) Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nature Cell Biology. DOI: 10.1038/ncb2074
How do evaluate medical students and residents, who are rotating through your Emergency Department? Do you have a structured framework for assessing their competencies?Have you heard of the RIME method of evaluating learners on their clinical rotation? Dr. Lou Pangaro (Vice Chair for Educational Programs in the Dept of Medicine at the Uniformed Services University) published a landmark article in 1999 on his simple yet effective approach in evaluating medical students and residents. I had the pl........ Read more »
Pangaro, L. (1999) A new vocabulary and other innovations for improving descriptive in-training evaluations. Academic Medicine, 74(11), 1203-7. DOI: 10.1097/00001888-199911000-00012
I would have had the headline read, "Exercising exercise's confirmation bias" but figured that wouldn't be as grabby.From the only publishable because the world has such a huge crush on exercise impacting on weight file comes the, Effect of change in physical activity on body fatness over a 10-y period in the Doetinchem Cohort Study published ahead of print in the American Journal of Clinical Nutrition.The study is just one of many in a long string of studies that fail to show any dramatic benef........ Read more »
May, A., Bueno-de-Mesquita, H., Boshuizen, H., Spijkerman, A., Peeters, P., & Verschuren, W. (2010) Effect of change in physical activity on body fatness over a 10-y period in the Doetinchem Cohort Study. American Journal of Clinical Nutrition. DOI: 10.3945/ajcn.2010.29404
The hungrier an animal becomes, the more risks it's prepared to take in the search for food. Now, for the first time, Mkael Symmonds and colleagues have shown that our animal instinct to maintain a balanced metabolic state influences our decision-making in other contexts, including finance.
Nineteen male participants performed the same gambling task on three occasions, a week apart: either after a fourteen hour fast; immediately after eating a standard two-thousand calorie meal; or one hour aft........ Read more »
Symmonds, M., Emmanuel, J., Drew, M., Batterham, R., & Dolan, R. (2010) Metabolic State Alters Economic Decision Making under Risk in Humans. PLoS ONE, 5(6). DOI: 10.1371/journal.pone.0011090
Translation: A Mediterranean-style dietary pattern protected against onset of metabolic syndrome (as defined by National Cholesterol Education Program Adult Treatment Panel III) in the Framingham Heart Study Offspring Cohort. Made you look! Don’t you just love acronyms? Lately it seems you gotta have a clever acronym for your scientific study or it won’t get published or remembered. [...]... Read more »
Rumawas, M., Meigs, J., Dwyer, J., McKeown, N., & Jacques, P. (2009) Mediterranean-style dietary pattern, reduced risk of metabolic syndrome traits, and incidence in the Framingham Offspring Cohort. American Journal of Clinical Nutrition, 90(6), 1608-1614. DOI: 10.3945/ajcn.2009.27908
Here’s a mini run-down of the woo-logic that is to follow, straight from the self-proclaimed soyologist, Jim Rutz:
Soy is very popular today.
When soy is consumed, estrogen rises within your system.
Elevated estrogen levels feminize you.
Gay men are feminine.
Pregnant women who eat a surplus of soy are feminizing their male fetuses.
Male babies who admit to being gay later in life that are born from soy-eating mamas need to realize that it was from the soy.
The rise of homosexuality is du........ Read more »
Brodie HK, Gartrell N, Doering C, & Rhue T. (1974) Plasma testosterone levels in heterosexual and homosexual men. The American journal of psychiatry, 131(1), 82-3. PMID: 4808435
Outreach and education are two areas that stand to gain from developments in semantic astronomy and an increased scientific presence on the web. Big changes have already taken place, driven by a community eager to connect and communicate about the research we do every day. As part of a panel at the AstroInformatics 2010 conference [...]... Read more »
Victoria Stodden. (2010) Open science: policy implications for the evolving phenomenon of user-led scientific innovation. JCOM, 9(1). info:/
In day two, Evolution 2010 is already feeling a mite overwhelming. I started the morning in the SSE symposium on speciation and the origin of dimorphism, then spent the rest of the day bouncing from talk to talk and preparing for my own presentation, which is tomorrow at 9:30. I'm going to bed early tonight, I think.
There's a new daily wrap-up podcast over at Evolution, Development, and Genomics, and, if you haven't been following the conference on Twitter, check hashtag #evol2010 or this list........ Read more »
Butler, M., & King, A. (2004) Phylogenetic comparative analysis: a modeling approach for adaptive evolution. The American Naturalist, 164(6), 683-95. DOI: 10.1086/426002
A new paper published online this week in the Journal of Cerebral Blood Flow & Metabolism this week discusses the infamous problem of circular analysis in fMRI research. The paper is aptly titled “Everything you never wanted to know about circular analysis, but were afraid to ask,” and is authored by several well-known biostatisticians and [...]... Read more »
Kriegeskorte N, Lindquist MA, Nichols TE, Poldrack RA, & Vul E. (2010) Everything you never wanted to know about circular analysis, but were afraid to ask. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. PMID: 20571517
This is a paper in which Sci has a certain amount of personal investment. You see, Sci has a family member who suffers from rheumatoid arthritis. And when I say suffer, I mean she suffers terribly. Rheumatoid arthritis is an autoimmune disease where you own body attacks the lining of the membranes between your joints. The result is painful swelling and stiffness (arthritis) which usually affects the smaller joints first (like your fingers) and which can severely impair your quality of life. ........ Read more »
Kimio Nasu, Hitoshi Kohsaka, Yoshinori Nonomura, Yoshio Terada, Hiroshi Ito, Katsuiku Hirokawa, and Nobuyuki Miyasaka. (2000) Adenoviral Transfer of Cyclin-Dependent Kinase Inhibitor Genes Suppresses Collagen-Induced Arthritis in Mice. Journal of Immunology, 7246-7252. info:/
The association between creativity and mental illness is sort of a cliché – but that doesn't mean there's nothing to it. Standard examples given include Vincent van Gogh, Robert Lowell, and John Nash.There has been a rather large amount of research into the connection, and a large number of biographical accounts of famous creative people who also suffered from mental illness. But the neurobiological details are emerging only slowly. After all, our understanding of the biological roo........ Read more »
de Manzano, �., Cervenka, S., Karabanov, A., Farde, L., & Ullén, F. (2010) Thinking Outside a Less Intact Box: Thalamic Dopamine D2 Receptor Densities Are Negatively Related to Psychometric Creativity in Healthy Individuals. PLoS ONE, 5(5). DOI: 10.1371/journal.pone.0010670
Hard, empirical, irrefutable evidence compiled via biopsies, genetic and molecular tests are beginning to show that offshore stem cell "clinics" are delivering anything but cures in people.... Read more »
Thirabanjasak, D., Tantiwongse, K., & Thorner, P. (2010) Angiomyeloproliferative Lesions Following Autologous Stem Cell Therapy. Journal of the American Society of Nephrology, 21(7), 1218-1222. DOI: 10.1681/ASN.2009111156
Amariglio N, Hirshberg A, Scheithauer BW, Cohen Y, Loewenthal R, Trakhtenbrot L, Paz N, Koren-Michowitz M, Waldman D, Leider-Trejo L.... (2009) Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS medicine, 6(2). PMID: 19226183
Americans eat two to three times the recommended amount of salt every day. Part of the problem may lie not in our foods, but in our genes.... Read more »
Chang WI, Chung JW, Kim YK, Chung SC, & Kho HS. (2006) The relationship between phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) taster status and taste thresholds for sucrose and quinine. Archives of oral biology, 51(5), 427-32. PMID: 16297856
Hayes JE, Sullivan BS, & Duffy VB. (2010) Explaining variability in sodium intake through oral sensory phenotype, salt sensation and liking. Physiology , 100(4), 369-80. PMID: 20380843
Ever since I first looked at this NYT visualization by Amanda Cox, I’ve always wanted to reproduce this in R. This is a plot that stacks multiple time series onto one another, with the width of the river/ribbon/hourglass representing the strength at each time. The NYT article used box office revenue as the width of the river. It’s also an interactive web app. thanks to some help from graphic designers.... Read more »
Havre, S., Hetzler, E., Whitney, P., & Nowell, L. (2002) ThemeRiver: visualizing thematic changes in large document collections. IEEE Transactions on Visualization and Computer Graphics, 8(1), 9-20. DOI: 10.1109/2945.981848
Humans, like all other primates, are obsessed by their peer group of colleagues and acquaintances. And that's for good reason because, for primates, being excluded from the group can be lethal.
So what do you do if you find yourself being ostracised? Well, for humans at least, one option is to turn to religion. Religion, after all, provides a ready-made community for those who conform to the group ideology – and even for those who don't, religion offers a virtual world of supernatural buddies........ Read more »
Aydin, N., Fischer, P., & Frey, D. (2010) Turning to God in the Face of Ostracism: Effects of Social Exclusion on Religiousness. Personality and Social Psychology Bulletin, 36(6), 742-753. DOI: 10.1177/0146167210367491
I know, it’s Monday and such cheer about work should be reserved for people with no life – but helping people return to work has been and still is one of my favourite parts of pain management. A pity that work rehabilitation has become somewhat far removed from pain management as it is practiced in … Read more... Read more »
Ammendolia, C., Cassidy, D., Steensta, I., Soklaridis, S., Boyle, E., Eng, S., Howard, H., Bhupinder, B., & Côté, P. (2009) Designing a workplace return-to-work program for occupational low back pain: an intervention mapping approach. BMC Musculoskeletal Disorders, 10(1), 65. DOI: 10.1186/1471-2474-10-65
It seems like years ago now, well, it is years ago now, that I did this study with The Walking Cortex (TWC, Paul Hodges). This was one of my PhD studies. I think it is quite a groovy study. We gave supposedly normal healthy volunteers painful electric shocks, through electrodes placed over the back of [...]... Read more »
Moseley GL, Nicholas MK, & Hodges PW. (2004) Does anticipation of back pain predispose to back trouble?. Brain : a journal of neurology, 127(Pt 10), 2339-47. PMID: 15282214
Ching CT, Chow DH, Yao FY, & Holmes AD. (2003) The effect of cyclic compression on the mechanical properties of the inter-vertebral disc: an in vivo study in a rat tail model. Clinical biomechanics (Bristol, Avon), 18(3), 182-9. PMID: 12620780
Cholewicki J, & McGill SM. (1994) EMG assisted optimization: a hybrid approach for estimating muscle forces in an indeterminate biomechanical model. Journal of biomechanics, 27(10), 1287-9. PMID: 7962016
Flor, H., & Turk, D. (1989) Psychophysiology of chronic pain: Do chronic pain patients exhibit symptom-specific psychophysiological responses?. Psychological Bulletin, 105(2), 215-259. DOI: 10.1037//0033-2909.105.2.215
Flor H, Birbaumer N, Schulte W, & Roos R. (1991) Stress-related electromyographic responses in patients with chronic temporomandibular pain. Pain, 46(2), 145-52. PMID: 1836258
Flor H, Birbaumer N, Schugens MM, & Lutzenberger W. (1992) Symptom-specific psychophysiological responses in chronic pain patients. Psychophysiology, 29(4), 452-60. PMID: 1410176
Gardner-Morse MG, & Stokes IA. (1998) The effects of abdominal muscle coactivation on lumbar spine stability. Spine, 23(1), 86. PMID: 9460158
Graven-Nielsen T, Svensson P, & Arendt-Nielsen L. (1997) Effects of experimental muscle pain on muscle activity and co-ordination during static and dynamic motor function. Electroencephalography and clinical neurophysiology, 105(2), 156-64. PMID: 9152211
Hodges PW. (2001) Changes in motor planning of feedforward postural responses of the trunk muscles in low back pain. Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale, 141(2), 261-6. PMID: 11713638
Hodges PW, & Richardson CA. (1999) Transversus abdominis and the superficial abdominal muscles are controlled independently in a postural task. Neuroscience letters, 265(2), 91-4. PMID: 10327176
Hodges P, Kaigle Holm A, Holm S, Ekström L, Cresswell A, Hansson T, & Thorstensson A. (2003) Intervertebral stiffness of the spine is increased by evoked contraction of transversus abdominis and the diaphragm: in vivo porcine studies. Spine, 28(23), 2594-601. PMID: 14652476
Hodges PW, Moseley GL, Gabrielsson A, & Gandevia SC. (2003) Experimental muscle pain changes feedforward postural responses of the trunk muscles. Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale, 151(2), 262-71. PMID: 12783146
Keefe FJ, Bradley LA, & Crisson JE. (1990) Behavioral assessment of low back pain: identification of pain behavior subgroups. Pain, 40(2), 153-60. PMID: 2137905
Lethem J, Slade PD, Troup JD, & Bentley G. (1983) Outline of a Fear-Avoidance Model of exaggerated pain perception--I. Behaviour research and therapy, 21(4), 401-8. PMID: 6626110
Moseley GL, Nicholas MK, & Hodges PW. (2004) Pain differs from non-painful attention-demanding or stressful tasks in its effect on postural control patterns of trunk muscles. Experimental brain research., 156(1), 64-71. PMID: 14689133
Slade PD, Troup JD, Lethem J, & Bentley G. (1983) The Fear-Avoidance Model of exaggerated pain perception--II. Behaviour research and therapy, 21(4), 409-16. PMID: 6626111
Vlaeyen, J. (1995) Fear of movement/(re)injury in chronic low back pain and its relation to behavioral performance. Pain, 62(3), 363-372. DOI: 10.1016/0304-3959(94)00279-N
Zedka M, Prochazka A, Knight B, Gillard D, & Gauthier M. (1999) Voluntary and reflex control of human back muscles during induced pain. The Journal of physiology, 591-604. PMID: 10523425
Even at the most extreme edges of the flow of stuff out of the volcano Pompeii, at the far edge of the mud and ash that came from the volcano's explosion, the heat was sufficient to instantly kill everyone, even those inside their homes.
And that is how the people at Pompeii, who's remains were found trapped and partly preserved within ghostly body-shaped tombs within that pyroclastic flow, died. They did not suffocate. They did not get blown apart by force. They did not die of gas poisoning........ Read more »
Mastrolorenzo, G., Petrone, P., Pappalardo, L., & Guarino, F. (2010) Lethal Thermal Impact at Periphery of Pyroclastic Surges: Evidences at Pompeii. PLoS ONE, 5(6). DOI: 10.1371/journal.pone.0011127
Aschner and Ceccatelli (2010) review the relevant data for thimerosal as a cause of autism. They conclude there is "no reliable data indicating that administration of vaccines containing thimerosal is a primary cause ofautism. However, one cannot rule out the possibility that the individual gene profile and/or gene–environmentinteractions may play a role in modulating the response to acquired risk by modifying the individual susceptibility."Aschner and Ceccatelli first discuss a........ Read more »
Aschner, M., & Ceccatelli, S. (2009) Are Neuropathological Conditions Relevant to Ethylmercury Exposure?. Neurotoxicity Research, 18(1), 59-68. DOI: 10.1007/s12640-009-9113-2
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