You may live in many places throughout your life, but you have only one hometown. No matter what, your core is deeply affected by where you grew up (for me, that core is made of a fondness for fries covered with gravy, impassioned shouts of Bruuuuuce, and traumatic experiences with a teasing comb and hairspray…yes, that’s New Jersey). Just like us, a tumor is affected by its origin…its growth, malignancy, and responsiveness to treatment are all dependent on where the cancer cells came fr........ Read more »
Liu, C., Sage, J., Miller, M., Verhaak, R., Hippenmeyer, S., Vogel, H., Foreman, O., Bronson, R., Nishiyama, A., Luo, L.... (2011) Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma. Cell, 146(2), 209-221. DOI: 10.1016/j.cell.2011.06.014
There are 20 amino acids found in nature, but scientists have engineered a nematode worm to create a 21st – an entirely artificial amino acid.... Read more »
Fighting the lore of wikipedia is an increasingly futile battle but there are people who resist using and improving the online encyclopedia. The remarkable thing is that some of this resistance comes from the scientific and academic communities, two groups of people who are supposedly concerned with the dissemination of knowledge. Wikipedia is the lore With [...]... Read more »
Alexander L. Bond. (2011) Why ornithologists should embrace and contribute to Wikipedia. Ibis, 153(3), 640-641. DOI: 10.1111/j.1474-919X.2011.01135.x
PLoS ONE offers the confessions of a former medical ghostwriter: Being the Ghost in the Machine.
The article (which is open access and short, so well worth a read) explains how Linda Logdberg became a medical writer; what excited her about the job; what she actually did; and what made her eventually give it up.
Ghostwriting of course has a bad press at the moment and it's recently been banned by some leading research centres. Ghostwriting certainly is concerning, because of what it implies ab........ Read more »
Logdberg, L. (2011) Being the Ghost in the Machine: A Medical Ghostwriter's Personal View. PLoS Medicine, 8(8). DOI: 10.1371/journal.pmed.1001071
Buffer In previous posts I already expressed my doubt about this phenomenon: Internet Addiction. The biggest problem with studies defining a new syndrome is usually that they don’t use validated diagnostic tools but mostly some severity scale. Internet Addiction is not clearly defined in the recent scientific publications and research. Some researchers have adapted substance use [...]
No related posts.... Read more »
King, D., Delfabbro, P., Griffiths, M., & Gradisar, M. (2011) Assessing clinical trials of Internet addiction treatment: A systematic review and CONSORT evaluation. Clinical Psychology Review, 31(7), 1110-1116. DOI: 10.1016/j.cpr.2011.06.009
In research the decisions on the product and the corresponding supply chain are usually separated. This happens for a variety of reasons, one may be the reduction of problem complexity, another that the research focus is on a brown field approach where the products are seen as given.... Read more »
Lamothe, J., Hadjhamou, K., & Aldanondo, M. (2006) An optimization model for selecting a product family and designing its supply chain. European Journal of Operational Research, 169(3), 1030-1047. DOI: 10.1016/j.ejor.2005.02.007
At seventeen I discovered the perfume that would become my signature scent. It’s a warm, rich, inviting fragrance[i] that reminds me (and hopefully others) of a rose garden in full bloom. Despite this fullness, it’s light enough to wear all day and it’s been in the background of many of my life experiences. It announces [...]
... Read more »
Brun, J. (2000) The Production of Perfumes in Antiquity: The Cases of Delos and Paestum. American Journal of Archaeology, 104(2), 277. DOI: 10.2307/507452
Holland, R., Hendriks, M., & Aarts, H. (2005) Smells Like Clean Spirit: Nonconscious Effects of Scent on Cognition and Behavior. Psychological Science, 16(9), 689-693. DOI: 10.1111/j.1467-9280.2005.01597.x
Warrenburg, S. (2005) Effects of Fragrance on Emotions: Moods and Physiology. Chemical Senses, 30(Supplement 1). DOI: 10.1093/chemse/bjh208
Realization of an optical diode... Read more »
Feng, L., Ayache, M., Huang, J., Xu, Y., Lu, M., Chen, Y., Fainman, Y., & Scherer, A. (2011) Nonreciprocal Light Propagation in a Silicon Photonic Circuit. Science, 333(6043), 729-733. DOI: 10.1126/science.1206038
Statistical study of the distribution of Korean family names... Read more »
A summary of the IAS Immune Activation/Inflammation and HIV Disease Symposium... Read more »
Effros RB, Allsopp R, Chiu CP, Hausner MA, Hirji K, Wang L, Harley CB, Villeponteau B, West MD, & Giorgi JV. (1996) Shortened telomeres in the expanded CD28-CD8 cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS (London, England), 10(8). PMID: 8828735
Giorgi, J., Hultin, L., McKeating, J., Johnson, T., Owens, B., Jacobson, L., Shih, R., Lewis, J., Wiley, D., Phair, J.... (1999) Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor Usage. The Journal of Infectious Diseases, 179(4), 859-870. DOI: 10.1086/314660
Brenchley, J., Price, D., Schacker, T., Asher, T., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D.... (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Medicine, 12(12), 1365-1371. DOI: 10.1038/nm1511
Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM.... (2011) A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4 T cell response. The Journal of infectious diseases, 203(7), 960-8. PMID: 21402547
J Buzón, M., Massanella, M., Llibre, J., Esteve, A., Dahl, V., Puertas, M., Gatell, J., Domingo, P., Paredes, R., Sharkey, M.... (2010) HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects. Nature Medicine, 16(4), 460-465. DOI: 10.1038/nm.2111
Sylwester, A. (2005) Broadly targeted human cytomegalovirus-specific CD4 and CD8 T cells dominate the memory compartments of exposed subjects. Journal of Experimental Medicine, 202(5), 673-685. DOI: 10.1084/jem.20050882
Naeger DM, Martin JN, Sinclair E, Hunt PW, Bangsberg DR, Hecht F, Hsue P, McCune JM, & Deeks SG. (2010) Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease. PloS one, 5(1). PMID: 20126452
Mehandru S, Poles MA, Tenner-Racz K, Jean-Pierre P, Manuelli V, Lopez P, Shet A, Low A, Mohri H, Boden D.... (2006) Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection. PLoS medicine, 3(12). PMID: 17147468
Schacker TW, Reilly C, Beilman GJ, Taylor J, Skarda D, Krason D, Larson M, & Haase AT. (2005) Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count. AIDS (London, England), 19(18), 2169-71. PMID: 16284469
Kelley CF, Kitchen CM, Hunt PW, Rodriguez B, Hecht FM, Kitahata M, Crane HM, Willig J, Mugavero M, Saag M.... (2009) Incomplete peripheral CD4 cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 48(6), 787-94. PMID: 19193107
Gandhi RT, Spritzler J, Chan E, Asmuth DM, Rodriguez B, Merigan TC, Hirsch MS, Shafer RW, Robbins GK, Pollard RB.... (2006) Effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1-positive subjects: results from ACTG 384. Journal of acquired immune deficiency syndromes (1999), 42(4), 426-34. PMID: 16810109
Schacker, T., Brenchley, J., Beilman, G., Reilly, C., Pambuccian, S., Taylor, J., Skarda, D., Larson, M., Douek, D., & Haase, A. (2006) Lymphatic Tissue Fibrosis Is Associated with Reduced Numbers of Naive CD4 T Cells in Human Immunodeficiency Virus Type 1 Infection. Clinical and Vaccine Immunology, 13(5), 556-560. DOI: 10.1128/CVI.13.5.556-560.2006
Zeng M, Smith AJ, Wietgrefe SW, Southern PJ, Schacker TW, Reilly CS, Estes JD, Burton GF, Silvestri G, Lifson JD.... (2011) Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. The Journal of clinical investigation, 121(3), 998-1008. PMID: 21393864
Hansson, G., & Libby, P. (2006) The immune response in atherosclerosis: a double-edged sword. Nature Reviews Immunology, 6(7), 508-519. DOI: 10.1038/nri1882
Tilg, H., & Hotamisligil, G. (2006) Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance. Gastroenterology, 131(3), 934-945. DOI: 10.1053/j.gastro.2006.05.054
Sereti I, Anthony KB, Martinez-Wilson H, Lempicki R, Adelsberger J, Metcalf JA, Hallahan CW, Follmann D, Davey RT, Kovacs JA.... (2004) IL-2-induced CD4 T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation. Blood, 104(3), 775-80. PMID: 15090457
Abrams D. (2009) Interleukin-2 Therapy in Patients with HIV Infection. New England Journal of Medicine, 361(16), 1548-1559. DOI: 10.1056/NEJMoa0903175
Starch is that stuff that stiffens your shirts. It's also what most people eat for fuel. Wheat, rice, corn, oats, potatoes are all very starchy foods. Many popular diet plans call starch a second-rate food that should be avoided at all costs. No-starch and low starch diets are favored by irritable bowel communities, while former Weight Watchers, Jenny Craig and Atkins enthusiasts love the new Carb Lovers Diet praising starch. Yet, there may be something good about starch even for those with........ Read more »
Bird AR, Conlon MA, Christophersen CT, & Topping DL. (2010) Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics. Beneficial microbes, 1(4), 423-31. PMID: 21831780
Several cases of botulism in Alaskan Natives have occurred as a result of changing Alaskan Native methods of fermenting meat. Traditional food preparation and storage techniques of burying meat underground to ferment have since been modified by the introduction of Western conveniences; Tupperware containers and sealable plastic bags are now being used to create a meaty, anaerobic environment that C. botulinum is happy to vacation in. ... Read more »
McLaughlin JB. (2003) Outbreak of Botulism Type E Associated With Eating a Beached Whale--Western Alaska, July 2002. JAMA: The Journal of the American Medical Association, 289(7), 836-838. DOI: 10.1001/jama.289.7.836
Do you feel like your grandfather adds more salt to his soup each time you see him? Turns out this is actually one of the physiological effects of aging. In fact, Stevens et al.  reported that the elder required twice as much salt as the young before detecting it in their tomato soup.... Read more »
Wysocki CJ, & Pelchat ML. (1993) The effects of aging on the human sense of smell and its relationship to food choice. Critical reviews in food science and nutrition, 33(1), 63-82. PMID: 8424856
In part I and part II, we discussed several of the gender gaps in Wikipedia. In this part, we'll talk about reverted edits, blocking, and their association with female and male editors. .
Blocking The hypothesis here was that "Female editors are less likely to be blocked." However, there wasn't a statistically significant difference in the percentage of females blocked (4.39%) and males blocked (4.52%). Surprisingly, females were significantly more likely to be blocked indefinitely (3.85% and 3........ Read more »
Lam, S., Uduwage, A., Dong, Z., Sen, S., Musicant, D. R., Terveen, L., & Terveen, J. (2011) WP:Clubhouse? An Exploration of Wikipedia’s Gender Imbalance. WikiSym’11, October 3–5, Mountain View, California. info:/
One of the main background themes in my history of life series was that extinctions will always happen – they’re a natural part of the biosphere’s evolution. But I never really explained what a mass extinction is. For example, the case of mayflies, who emerge as sexually mature adults simultaneously and live between a few [...]... Read more »
Now that I’m back from visiting amusement parks in Orlando, FL, I think it’s as good a time as any to reveal a little secret of mine: I don’t wear sunscreen. (“Not even in Florida?!”) Not even in Florida. In August.
I want to be really emphatic in saying that I am NOT advocating for people to go without sunscreen. You have to do what works for you. I was raised in sunny places and I almost never get sunburns, and now that I live in New England I’m much more........ Read more »
In a more ideal world, cattle would be free to lead lives consistent with their ancestry as nomadic grazers covering wide ranges. Of course, this isn’t a perfect world, particularly for the cows and other farmyard animals … Continue reading →... Read more »
Bertenshaw, C., & Rowlinson, P. (2009) Exploring Stock Managers' Perceptions of the Human–Animal Relationship on Dairy Farms and an Association with Milk Production. Anthrozoos: A Multidisciplinary Journal of The Interactions of People , 22(1), 59-69. DOI: 10.2752/175303708X390473
A few days ago (the day before my 30th birthday actually), my most recent paper, along with Vasili Hauryliuk and Tanel Tenson, "The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life" was published with PloS ONE. Hurrah!The RSH proteins comprise a superfamily of enzymes that synthesize and/or hydrolyze the alarmone ppGpp. ppGpp is a nucleotide that acts as an alarm signal, activating the “stringent” response........ Read more »
Gemma C. Atkinson, Tanel Tenson, & Vasili Hauryliuk. (2011) The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life. PLoS ONE, 6(8). info:/
Researchers at Boulder examined the neuroprotective benefits of exercise on infection- and aging-induced neuroinflammation, neural degenerative, and learning impairments. A win-win for physiological and behavioral systems. ... Read more »
Barrientos RM, Frank MG, Crysdale NY, Chapman TR, Ahrendsen JT, Day HE, Campeau S, Watkins LR, Patterson SL, & Maier SF. (2011) Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(32), 11578-86. PMID: 21832188
The advent of neuroimaging techniques such as magnetic resonance imaging (MRI) has revolutionized autism research. We can now look into the brain and see the "neural correlates" of autism. But, as with any form of correlation, identifying a neural correlate doesn't necessarily mean that we have identified a neural cause.
A case in point. Earlier this week I stumbled across a press release doing the rounds of the internet, proclaiming that "Brain imaging research reveals why autistic indiv........ Read more »
Mizuno A, Liu Y, Williams DL, Keller TA, Minshew NJ, & Just MA. (2011) The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism. Brain : a journal of neurology. PMID: 21733887
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