Man chasing rabbit
(From “Fliegende Blätter”, Munich, 1889)
Everyone knows about rabbits in Australia. Introduced in the mid-1800s, they multiplied ridiculously and are their way across the country, leaving barren devastation behind them.
Myxomavirus, a poxvirus that originated in South America, was introduced in the early 1950s and temporarily controlled the rabbit population, cutting their numbers [...]... Read more »
Kerr, P., Kitchen, A., & Holmes, E. (2009) Origin and Phylodynamics of Rabbit Hemorrhagic Disease Virus. Journal of Virology, 83(23), 12129-12138. DOI: 10.1128/JVI.01523-09
Uri Alon, a PI in the Weizmann Institute in Rehovot, Israel, recently published an article in Molecular Cell where he discusses how to build a motivated research group.
Motivation in a research group is very important as that is the way that work actually gets done. Its not enough to go uninspired through the motions and conduct experiments because if it doesn’t work out – what is going to push you to keep trying? I personally have spoken to many involved in research asking what i........ Read more »
People hold strong feelings about the meanings of irony and sarcasm. Just look at the reaction to Alanis Morissette's global hit 'ironic' - despite commercial success, the apparent misunderstanding of irony conveyed by the song provoked a chorus of derision (at least everyone agreed that this state of affairs was ironic). So I'd say it's with some courage that Melanie Glenwright and Penny Pexman have chosen to investigate the tricky issue of when exactly children learn the distinction between sa........ Read more »
Glenwright M, & Pexman PM. (2010) Development of children's ability to distinguish sarcasm and verbal irony*. Journal of child language, 37(2), 429-51. PMID: 19523264
Cosmology has, for a decade, had its "standard model", which largely explains most of the cosmological phenomena that astronomers are able to observe. Except for a relatively small number of things that don't seem to make sense in the model. Prominent among the latter are dwarf galaxies – by one definition, galaxies having less than 10% of the total mass of the Milky Way.The standard model of cosmology is known officially as the Λ-cold-dark-matter model – ΛCDM. (This th........ Read more »
Governato, F., Brook, C., Mayer, L., Brooks, A., Rhee, G., Wadsley, J., Jonsson, P., Willman, B., Stinson, G., Quinn, T.... (2010) Bulgeless dwarf galaxies and dark matter cores from supernova-driven outflows. Nature, 463(7278), 203-206. DOI: 10.1038/nature08640
This article discussed in this post, isn’t recent but the conclusion is very nuanced which isn’t always the case with publications especially in news media about social networking and kids or adolescents. Seems that politicians are advocating measures to restrict social networking for children in order to prevent assumed online sexual exploitation and Internet harassment.
Related posts:Searching Dating Sites Reduces Decision Quality Dating sites as well as social netw........ Read more »
Ybarra, M., & Mitchell, K. (2008) How Risky Are Social Networking Sites? A Comparison of Places Online Where Youth Sexual Solicitation and Harassment Occurs. PEDIATRICS, 121(2). DOI: 10.1542/peds.2007-0693
by Drew Rosielle MD in Pallimed: a Hospice & Palliative Medicine Blog
A few analyses from the Coping With Cancer Study have been published recently, all in the Journal of Clinical Oncology. We've published extensively about the CWCS (see here for more). Briefly, it was a prospective, US multi-institutional study of several hundred advanced cancer patients (& their family caregivers) which measured at baseline, among many things, characteristics of patient coping, communication with clinicians, and care preferences. Patients were followed through death, and ........ Read more »
Loggers, E., Maciejewski, P., Paulk, E., DeSanto-Madeya, S., Nilsson, M., Viswanath, K., Wright, A., Balboni, T., Temel, J., Stieglitz, H.... (2009) Racial Differences in Predictors of Intensive End-of-Life Care in Patients With Advanced Cancer. Journal of Clinical Oncology, 27(33), 5559-5564. DOI: 10.1200/JCO.2009.22.4733
Mack, J., Weeks, J., Wright, A., Block, S., & Prigerson, H. (2010) End-of-Life Discussions, Goal Attainment, and Distress at the End of Life: Predictors and Outcomes of Receipt of Care Consistent With Preferences. Journal of Clinical Oncology. DOI: 10.1200/JCO.2009.25.4672
Balboni, T., Paulk, M., Balboni, M., Phelps, A., Loggers, E., Wright, A., Block, S., Lewis, E., Peteet, J., & Prigerson, H. (2009) Provision of Spiritual Care to Patients With Advanced Cancer: Associations With Medical Care and Quality of Life Near Death. Journal of Clinical Oncology, 28(3), 445-452. DOI: 10.1200/JCO.2009.24.8005
by Drew Rosielle MD in Pallimed: a Hospice & Palliative Medicine Blog
NEJM has an editorial discussing withholding information from patients. It's a practical, casual discussion of 1) the fact that in real life we withhold information from patients all the time (e.g. don't go into all the details as they can be confusing, overwhelming, or superfluous), and 2) the fact that we decide all the time to withhold certain major pieces information out of a desire to protect the patient emotionally. It's the latter that is the real issue (e.g. not talking with a leuke........ Read more »
Epstein RM, Korones DN, & Quill TE. (2010) Withholding information from patients--when less is more. The New England journal of medicine, 362(5), 380-1. PMID: 20130252
Last year, I wrote about a scientific controversy over the structure of the influenza M2 proton channel, particularly over the protein's binding site for adamantane type anti-flu drugs. The Schnell/Chou model, based on solution NMR, had the drug binding to the outside of the channel, within the membrane (at a 4:1 drug:protein ratio). On the other hand, the Stouffer/DeGrado model had the drug binding inside the channel (1:1 ratio), based on X-ray crystallography studies.
A new study was recently........ Read more »
Cady, S., Schmidt-Rohr, K., Wang, J., Soto, C., DeGrado, W., & Hong, M. (2010) Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature, 463(7281), 689-692. DOI: 10.1038/nature08722
In the deliberations over humanity and its perceived uniqueness, a link is frequently made between our ability to support a rich, diverse culture and the origin of complex human behaviour. Yet what is often overlooked in our view of these two, clearly connected phenomena is the thread that weaves them together: the ability to coordinate [...]... Read more »
Chater, N. . (2009) Language Acquisition Meets Language Evolution. Cognitive Science. info:/10.1111/j.1551-6709.2009.01049.x
Laland KN, Odling-Smee J, & Myles S. (2010) How culture shaped the human genome: bringing genetics and the human sciences together. Nature reviews. Genetics, 11(2), 137-48. PMID: 20084086
Lycett, S., & Norton, C. (2010) A demographic model for Palaeolithic technological evolution: The case of East Asia and the Movius Line. Quaternary International, 211(1-2), 55-65. DOI: 10.1016/j.quaint.2008.12.001
Diabetes drug being tested for addiction.
It’s a mouthful: peroxisome proliferator activated receptor gamma (PPAR-gamma).
Peroxisomes are specialized subunits inside cells that help metabolize various substances, including fatty acids and certain toxins. A blockbuster member of this drug family—Avandia—is a much disputed but immensely lucrative diabetes medicine that may cause heart failure.
(Partial Agonist Ppar Gamma Cocrystal)--------->
PPAR gamma agonists belong to a class ........ Read more »
Maeda, T., Kiguchi, N., Fukazawa, Y., Yamamoto, A., Ozaki, M., & Kishioka, S. (2006) Peroxisome Proliferator-Activated Receptor Gamma Activation Relieves Expression of Behavioral Sensitization to Methamphetamine in Mice. Neuropsychopharmacology, 32(5), 1133-1140. DOI: 10.1038/sj.npp.1301213
Just about every article I read on women’s preferences for sexual dimorphism in men points out that the data are consistent with the good genes hypothesis. There are a couple of technical variations of this hypothesis, but they all are based on the reasonably well-established connection between testosterone and impeded immune system functioning. The idea [...]... Read more »
Johnston, V. (2001) Male facial attractiveness: evidence for hormone-mediated adaptive design. Evolution and Human Behavior, 22(4), 251-267. DOI: 10.1016/S1090-5138(01)00066-6
Wilcox, A. (2004) On the frequency of intercourse around ovulation: evidence for biological influences. Human Reproduction, 19(7), 1539-1543. DOI: 10.1093/humrep/deh305
One really cool aspect of using a software program like Recognise, is that you can keep tabs on whether or not patients actually do what we ask them to do. This is an important issue because any treatment that involves home exercises or training depends on people doing it! Historically, clinicians have used a training [...]... Read more »
Moseley GL. (2006) Do training diaries affect and reflect adherence to home programs?. Arthritis and rheumatism, 55(4), 662-4. PMID: 16874790
Today’s guest post is from a pharmacist who blogs under the pseudonym Avicenna, who looks at the evidence supporting the use of Coenzyme Q10 to treat statin-related muscle pain.
My pharmacy stocks plenty of natural health products (NHPs) and ensuring they can be used safely is challenging, given the limited information available on safety, quality, [...]... Read more »
MARCOFF, L., & THOMPSON, P. (2007) The Role of Coenzyme Q10 in Statin-Associated MyopathyA Systematic Review. Journal of the American College of Cardiology, 49(23), 2231-2237. DOI: 10.1016/j.jacc.2007.02.049
CASO, G., KELLY, P., MCNURLAN, M., & LAWSON, W. (2007) Effect of Coenzyme Q10 on Myopathic Symptoms in Patients Treated With Statins. The American Journal of Cardiology, 99(10), 1409-1412. DOI: 10.1016/j.amjcard.2006.12.063
I just came back up from our cellar, where I was looking through a couple of cardboard boxes that I hadn’t opened since we moved from Colorado. The boxes are full of research papers on benthic foraminifera, left over from my days of doing science. I ventured down there because a researcher from Sweden wants to have a reprint of one of my papers, and I don’t have an electronic file of it (I will after this).
Turns out the paper wasn’t in either of the two boxes, but in ........ Read more »
Tuck, I. (1995) Unidentified burrow surface trace from the clyde sea area. Netherlands Journal of Sea Research, 34(4), 331-335. DOI: 10.1016/0077-7579(95)90042-X
Many neuroscientists think of the thalamus – a compact structure lying right in the centre of the brain – simply as a relay station, where sensory information from the periphery converges and is then passed on to the cortex. The cortex is thought to be the site of perception and cognition, with different cortical areas specialized to subserve different functions. Communication between cortical areas can be mediated by axonal tracts running in the white matter of the cortex. This leads ........ Read more »
Theyel, B., Llano, D., & Sherman, S. (2009) The corticothalamocortical circuit drives higher-order cortex in the mouse. Nature Neuroscience, 13(1), 84-88. DOI: 10.1038/nn.2449
For a couple of years now, the focus of researchers on factors that identify ‘high risk’ of ongoing disability has turned from patients and onto providers. I’ve written before that health provider’s own beliefs about pain, particularly pain-related anxiety and avoidance, can change the advice they give. This can lead to less ‘reassurance’ about [...]... Read more »
Shaw WS, Pransky G, Winters T, Tveito TH, Larson SM, & Roter DL. (2009) Does the presence of psychosocial "yellow flags" alter patient-provider communication for work-related, acute low back pain?. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, 51(9), 1032-40. PMID: 19687758
Photo by D Sharon Pruitt
There's more evidence that many children have a mental health disorder and not enough get help. The first representative survey of children in the United States found that 13% of children ages 8 to 15 had at least one psychiatric disorders during one year. The data comes from the National Health and Nutrition Examination Survey (NHANES), a collaboration between the National Institute of Mental Health (NIMH) and the National Center for Health Statistics of the Centers f........ Read more »
Merikangas, K., He, J., Brody, D., Fisher, P., Bourdon, K., & Koretz, D. (2009) Prevalence and Treatment of Mental Disorders Among US Children in the 2001-2004 NHANES. PEDIATRICS, 125(1), 75-81. DOI: 10.1542/peds.2008-2598
It appears that we humans had taken oceans for granted for too long. A widely known fact is that most of what we discard makes its way to oceans. Oceans are sinks for all things including 1/3 of the carbon dioxide that has been released in the last 200 years. This has resulted in the acidification of the oceans. The science behind is that carbonic acid is formed when carbon dioxide dissolves in sea water. This raises the hydrogen ion concentration and bicarbonate ions, but limits carbonate ions......... Read more »
Shi D, Xu Y, Hopkinson BM, & Morel FM. (2010) Effect of ocean acidification on iron availability to marine phytoplankton. Science (New York, N.Y.), 327(5966), 676-9. PMID: 20075213
Fabry, V. (2008) OCEAN SCIENCE: Marine Calcifiers in a High-CO2 Ocean. Science, 320(5879), 1020-1022. DOI: 10.1126/science.1157130
Babyak (2000) examined the use of physical activity as a treatment for depression. Participants classified as clinically depressed were given, aerobic exercise, drugs or both as treatment. The exercise only group recovered as well as the other groups but had a lower relapse rate, perhaps caused by the participants feeling that they had a more active role in their treatment. The exercise group also a side effect of the participants getting fitter! There are many other studies associating par........ Read more »
Babyak M, Blumenthal JA, Herman S, Khatri P, Doraiswamy M, Moore K, Craighead WE, Baldewicz TT, & Krishnan KR. (2000) Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosomatic medicine, 62(5), 633-8. PMID: 11020092
A review of Thursday's Guze Symposium on disentangling the genetics of alcoholism, sponsored by the Washington University of St. Louis School of Medicine in honor of Samuel Guze, a pioneer in the field of alcohol abuse and alcoholism.... Read more »
Crabbe, J., Phillips, T., Harris, R., Arends, M., & Koob, G. (2006) Alcohol-related genes: contributions from studies with genetically engineered mice. Addiction Biology, 11(3-4), 195-269. DOI: 10.1111/j.1369-1600.2006.00038.x
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