The question of how new protein functions arise in evolution via duplication has a certain “chicken and egg” flavor to it. It’s clear that genes with new functions do often arise after older genes undergo a duplication event, but which comes first, the new function or the duplication? For a long time it seemed obvious [...]... Read more »
Deng C, Cheng CH, Ye H, He X, & Chen L. (2010) Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21115821
Why have I left it so long between the last posting and this one? Partly, of course, there was the Christmas break. Too many things to do (and besides, who is going to read this blog in preference to spending precious festive time with their loved ones?). Oh, and then there was that workshop on [...]... Read more »
Choi, J., & Moran, S. (2009) Why Not Procrastinate? Development and Validation of a New Active Procrastination Scale. The Journal of Social Psychology, 149(2), 195-212. DOI: 10.3200/SOCP.149.2.195-212
Steel, P. (2007) The nature of procrastination: A meta-analytic and theoretical review of quintessential self-regulatory failure. Psychological Bulletin, 133(1), 65-94. DOI: 10.1037/0033-2909.133.1.65
Wohl, M., Pychyl, T., & Bennett, S. (2010) I forgive myself, now I can study: How self-forgiveness for procrastinating can reduce future procrastination. Personality and Individual Differences, 48(7), 803-808. DOI: 10.1016/j.paid.2010.01.029
Last year I had the pleasure of temporarily leading our psychiatry department. It was a difficult but in the end rewarding job. That’s probably why a recent publication in Healthcare Executive drew my attention: The 10 most common myths about leadership.
Leadership and management are the same dynamic.Leadership is more about vision, culture and values within [...]
No related posts.... Read more »
When serial killers go unseen: The case of Trevor Joseph Hardy From Crime, Media and Culture UK headlines last week highlighted news regarding the denied plea of the ‘Yorkshire Ripper’ and confirmation he will spend all his life behind bars. This serial killer always sparks huge public interest. The article examines the differences in the [...]... Read more »
Wilson, D., Tolputt, H., Howe, N., & Kemp, D. (2010) When serial killers go unseen: The case of Trevor Joseph Hardy. Crime, Media, Culture, 6(2), 153-167. DOI: 10.1177/1741659010369952
Mitsukurina owstoni is a weird and scary species of shark, commonly known as the goblin shark.
It is very distinct from other sharks and has many unique and unshark-like traits, like its pink color! .
The species is often described as a "living fossil", thanks to its prehistoric appearance and its ancient lineage.... Read more »
Parsons, G., Ingram, G., & Havard, R. (2002) FIRST RECORD OF THE GOBLIN SHARK MITSUKURINA OWSTONI, JORDAN (FAMILY MITSUKURINIDAE) IN THE GULF OF MEXICO. Southeastern Naturalist, 1(2), 189-192. DOI: 10.1656/1528-7092(2002)001[0189:FROTGS]2.0.CO;2
Duffy, C. (1997) Further records of the goblin shark, (Lamniformes: Mitsukurinidae), from New Zealand . New Zealand Journal of Zoology, 24(2), 167-171. DOI: 10.1080/03014223.1997.9518111
Rincon, G., Vaske, T., & Gadig, O. (2012) Record of the goblin shark Mitsukurina owstoni (Chondrichthyes: Lamniformes: Mitsukurinidae) from the south-western Atlantic. Marine Biodiversity Records. DOI: 10.1017/S1755267211000923
Yano, K., Miya, M., Aizawa, M., & Noichi, T. (2007) Some aspects of the biology of the goblin shark, Mitsukurina owstoni, collected from the Tokyo Submarine Canyon and adjacent waters, Japan. Ichthyological Research, 54(4), 388-398. DOI: 10.1007/s10228-007-0414-2
Caira, J., & Runkle, L. (1993) Two new tapeworms from the goblin shark Mitsukurina owstoni off Australia. Systematic Parasitology, 26(2), 81-90. DOI: 10.1007/BF00009215
Today I watched a pair of Blue Tits paying a lot of attention to the inflorescences of Mahonia in the local park, coming back to them again and again. What were they doing? If you hear nectar feeding in birds you would most likely think on hummingbirds and the tropics. However, several bird groups feed on nectar in addition to hummingbirds, honeyeaters and sunbirds. In Australia, they are actually the main flower pollinators. Although nectar feeding behaviour is far less widespread, it does happ........ Read more »
Ford, H. (1985) Nectarivory and Pollination by Birds in Southern Australia and Europe. Oikos, 44(1), 127. DOI: 10.2307/3544053
Búrquez, A. (1989) Blue Tits, Parus caeruleus, as Pollinators of the Crown Imperial, Fritillaria Imperialis, in Britain. Oikos, 55(3), 335. DOI: 10.2307/3565592
Fitzpatrick, S. (1994) Nectar-feeding by suburban Blue Tits: contribution to the diet in spring. Bird Study, 41(2), 136-145. DOI: 10.1080/00063659409477210
By Steve Kamper I’m a physiotherapist, as physios (and we’re not alone here) we love to poke and prod our patients with our fingers and ask if it hurts. Anatomical training and experience tells us exactly which part we are poking and the knowing nod of the head followed by a somber and considered ‘aah [...]... Read more »
Siegenthaler A, Eichenberger U, Schmidlin K, Arendt-Nielsen L, & Curatolo M. (2010) What does local tenderness say about the origin of pain? An investigation of cervical zygapophysial joint pain. Anesthesia and analgesia, 110(3), 923-7. PMID: 20185669
Last year, University of Washington oceanographer Seelye Martin and his colleagues reported the discovery of an iceberg graveyard: a previously unreported underwater shoal near the Antarctic coast on which large icebergs occasionally run aground and break apart. One notable victim was B-15A, a Rhode Island-size iceberg that was the largest remnant of a far larger, 1000-foot [...]... Read more »
Martin, S., Drucker, R., Aster, R., Davey, F., Okal, E., Scambos, T., & MacAyeal, D. (2010) Kinematic and seismic analysis of giant tabular iceberg breakup at Cape Adare, Antarctica. Journal of Geophysical Research, 115(B6). DOI: 10.1029/2009JB006700
Did you know that salmon rely on their sense of smell (olfaction) for nearly every aspect of their lives, from locating food to avoiding predators? ... Read more »
Arthur Hasler, & Warren Wisby. (1951) Discrimination of Stream Odors by Fishes and Its Relation to Parent Stream Behavior. The American Naturalist, 85(823), 223. DOI: 10.1086/281672
W.J. Wisby, & A.D. Hasler. (1954) Effect of olfactory occlusion on migrating silver salmon (O. kisutch). Journal of the Fisheries Research Board of Canada, 472-478. info:/
Yamamoto, Y., Hino, H., & Ueda, H. (2010) Olfactory Imprinting of Amino Acids in Lacustrine Sockeye Salmon. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008633
Tierney, K., Sampson, J., Ross, P., Sekela, M., & Kennedy, C. (2008) Salmon Olfaction is Impaired by an Environmentally Realistic Pesticide Mixture. Environmental Science , 42(13), 4996-5001. DOI: 10.1021/es800240u
Sandahl, J., Baldwin, D., Jenkins, J., & Scholz, N. (2004) Odor-evoked field potentials as indicators of sublethal neurotoxicity in juvenile coho salmon (Oncorhynchus kisutch) exposed to copper, chlorpyrifos, or esfenvalerate. Canadian Journal of Fisheries and Aquatic Sciences, 61(3), 404-413. DOI: 10.1139/f04-011
The easiest answer to the title question is “cause side effects”. A more important theoretical and practical aspect of this question is: Do antidepressants have a general property experienced by everyone or are their effects only seen in the presence of depression? Antidepressant drugs have research support for a variety of non-depression indications including: chronic pain, fibromyalgia, migraine prophylaxis, irritable bowel syndrome and pathological crying and laughing.&nb........ Read more »
Serretti A, Calati R, Goracci A, Di Simplicio M, Castrogiovanni P, & De Ronchi D. (2010) Antidepressants in healthy subjects: what are the psychotropic/psychological effects?. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 20(7), 433-53. PMID: 20079613
In order to perform its function, protein should be properly folded. Therefore stability of this proteins’ native state is crucial for its function. Denatured protein can be toxic the cell and requires specialised machinery to degrade it, thus compromising cells fitness. Having a denatured protein is not equal to just not having a functional one, it is equal to not having a functional one and hiving some costly junk.Since stability is so crucial for proteins function, it must leave its trace i........ Read more »
Fu H, Grimsley G, Scholtz JM, & Pace CN. (2010) Increasing protein stability: importance of DeltaC(p) and the denatured state. Protein science : a publication of the Protein Society, 19(5), 1044-52. PMID: 20340133
Franzosa EA, & Xia Y. (2009) Structural determinants of protein evolution are context-sensitive at the residue level. Molecular biology and evolution, 26(10), 2387-95. PMID: 19597162
Drummond DA, & Wilke CO. (2008) Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution. Cell, 134(2), 341-52. PMID: 18662548
Geiler-Samerotte KA, Dion MF, Budnik BA, Wang SM, Hartl DL, & Drummond DA. (2011) Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast. Proceedings of the National Academy of Sciences of the United States of America, 108(2), 680-5. PMID: 21187411
Loladze VV, Ermolenko DN, & Makhatadze GI. (2001) Heat capacity changes upon burial of polar and nonpolar groups in proteins. Protein science : a publication of the Protein Society, 10(7), 1343-52. PMID: 11420436
DePristo MA, Weinreich DM, & Hartl DL. (2005) Missense meanderings in sequence space: a biophysical view of protein evolution. Nature reviews. Genetics, 6(9), 678-87. PMID: 16074985
PI3-kinase inhibition is becoming quite a hot topic in cancer research – for those of you interested in learning about the compounds in this area, you can find out more from previous posts here and here as background information before … Continue reading →... Read more »
Donev, I., Wang, W., Yamada, T., Li, Q., Takeuchi, S., Matsumoto, K., Yamori, T., Nishioka, Y., Sone, S., & Yano, S. (2011) Transient PI3K Inhibition Induces Apoptosis and Overcomes HGF-mediated Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer. Clinical Cancer Research. DOI: 10.1158/1078-0432.CCR-10-1993
Kobayashi, S., Boggon, T., Dayaram, T., Jänne, P., Kocher, O., Meyerson, M., Johnson, B., Eck, M., Tenen, D., & Halmos, B. (2005) Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib . New England Journal of Medicine, 352(8), 786-792. DOI: 10.1056/NEJMoa044238
Engelman, J., Zejnullahu, K., Mitsudomi, T., Song, Y., Hyland, C., Park, J., Lindeman, N., Gale, C., Zhao, X., Christensen, J.... (2007) MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling. Science, 316(5827), 1039-1043. DOI: 10.1126/science.1141478
Yano, S., Wang, W., Li, Q., Matsumoto, K., Sakurama, H., Nakamura, T., Ogino, H., Kakiuchi, S., Hanibuchi, M., Nishioka, Y.... (2008) Hepatocyte Growth Factor Induces Gefitinib Resistance of Lung Adenocarcinoma with Epidermal Growth Factor Receptor-Activating Mutations. Cancer Research, 68(22), 9479-9487. DOI: 10.1158/0008-5472.CAN-08-1643
Turke, A., Zejnullahu, K., Wu, Y., Song, Y., Dias-Santagata, D., Lifshits, E., Toschi, L., Rogers, A., Mok, T., & Sequist, L. (2010) Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC. Cancer Cell, 17(1), 77-88. DOI: 10.1016/j.ccr.2009.11.022
Kasahara, K., Arao, T., Sakai, K., Matsumoto, K., Sakai, A., Kimura, H., Sone, T., Horiike, A., Nishio, M., Ohira, T.... (2010) Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Adenocarcinoma. Clinical Cancer Research, 16(18), 4616-4624. DOI: 10.1158/1078-0432.CCR-10-0383
Okamoto, W., Okamoto, I., Tanaka, K., Hatashita, E., Yamada, Y., Kuwata, K., Yamaguchi, H., Arao, T., Nishio, K., Fukuoka, M.... (2010) TAK-701, a Humanized Monoclonal Antibody to Hepatocyte Growth Factor, Reverses Gefitinib Resistance Induced by Tumor-Derived HGF in Non-Small Cell Lung Cancer with an EGFR Mutation. Molecular Cancer Therapeutics, 9(10), 2785-2792. DOI: 10.1158/1535-7163.MCT-10-0481
Engelman, J., Zejnullahu, K., Gale, C., Lifshits, E., Gonzales, A., Shimamura, T., Zhao, F., Vincent, P., Naumov, G., Bradner, J.... (2007) PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib. Cancer Research, 67(24), 11924-11932. DOI: 10.1158/0008-5472.CAN-07-1885
A troubling fact about language is that words can be used in more than one way. For instance, I can throw a ball, I can throw a party, and I can throw a party that is also a ball.
These cats are having a ball.
The Causative Alternation
Sometimes the relationship between different uses of a word is completely arbitrary. If there's any relationship between the different meanings of ball, most people don't know it. But sometimes there are straightforward, predictable relationships. For instance, ........ Read more »
Gropen, J., Pinker, S., Hollander, M., Goldberg, R., & Wilson, R. (1989) The Learnability and Acquisition of the Dative Alternation in English. Language, 65(2), 203. DOI: 10.2307/415332
Ben Ambridge, Julian M. Pine, & Caroline F. Rowland. (2011) Children use verb semantics to retreat from overgeneralization errors. Cognitive Linguistics. info:/
What are the major obstacles to a successful merger? Today I'll have a look at the 2003 article by Langabeer and Seifert. The authors argue that supply chain integration plays a major role before, during and after the merger.
Why is the Supply Chain Key?
The authors start by making the case for the supply chain as one of the major drivers of financial performance in a company. After analyzing quantitative data from 400 mergers during a ten-year period, exploring relationships between merge........ Read more »
Langabeer, J., & Seifert, D. (2003) Supply Chain Integration: The Key to Merger Success. Supply Chain Management Review. info:/
From both a medical and a scientific viewpoint, the evolution of viruses is extremely important to us; viral adaptation to their ever changing environment is responsible for major morbidity and mortality worldwide so maybe studying this may allow us to predict virus evolution in the future and may help prevent pandemics occuring? We kind of [...]... Read more »
Kitchen A, Shackelton LA, & Holmes EC. (2011) Family level phylogenies reveal modes of macroevolution in RNA viruses. Proceedings of the National Academy of Sciences of the United States of America, 108(1), 238-43. PMID: 21173251
The question of ‘human nature’ is a fraught one for many anthropologists, especially those of us who pay special attention to human variation, Darwinian theory, and dynamic approaches to diversity in developmental questions.
The very concept ‘human nature’ can be the theoretical equivalent of the double-bind question, ‘So can you confirm that you no longer are a Creationist?’ Even conceding to respond to the question places us in a position where we wind up between the Scylla of th........ Read more »
For men working together, stress plus coffee could be toxic
If a meeting becomes stressful, does it help, or make things worse, if team members drink lots of coffee? A study by Lindsay St. Claire and colleagues that set out to answer this question has uncovered an unexpected sex difference. For two men collaborating or negotiating under stressful circumstances, caffeine consumption was bad news, undermining their performance and confidence. By contrast, for pairs of women, drinking caffeine of........ Read more »
St. Claire, L., Hayward, R., & Rogers, P. (2010) Interactive Effects of Caffeine Consumption and Stressful Circumstances on Components of Stress: Caffeine Makes Men Less, But Women More Effective as Partners Under Stress. Journal of Applied Social Psychology, 40(12), 3106-3129. DOI: 10.1111/j.1559-1816.2010.00693.x
We found a great post this past weekend on fastcompany.com which we thought we’d share with you. Author David Zax describes an interactive video game designed by researchers in the bioengineering department of Stanford University that uses living cells as part of the game mechanics. These “Biotic Games” are played much like any arcade classic [...]... Read more »
by Rita Handrich in The Jury Room
Martin Luther King, Jr. committed adultery. So did Eliot Spitzer. And although CNN’s David Gergen insists he did not compare Eliot Spitzer with Martin Luther King, Jr., we know of some researchers who did. Effron & Monin (2010) wondered what made the difference in how we decide to punish some people for bad behavior let others [...]
Related posts:Eliot Spitzer, Uncivil Behavior & Possibilities of Redemption
Apology redux: Doing it right (and doing it wrong)
... Read more »
Effron DA, & Monin B. (2010) Letting people off the hook: when do good deeds excuse transgressions?. Personality and social psychology bulletin, 36(12), 1618-34. PMID: 20978222
Today’s image is from a paper describing a new microscopy method that allows the best of both worlds – fluorescent AND electron microscopy. The images in this paper are fantastic, but I especially can’t wait to see what images are down the road using this new method. ........ Read more »
Kukulski, W., Schorb, M., Welsch, S., Picco, A., Kaksonen, M., & Briggs, J. (2011) Correlated fluorescence and 3D electron microscopy with high sensitivity and spatial precision. originally published in The Journal of Cell Biology, 192(1), 111-119. DOI: 10.1083/jcb.201009037
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