Some pretty cool links for your weekend:
Jurassic Park beer:
Fossil Fuels Brewing Co. makes beer with an Eocene-era yeast, formerly encased in a 45 million year old chunk of amber! Incredible, but apparently true. Viable Bacillus spores were discovered first in 25-40 million year old amber by Raul Cano (these spores are so tough you can't kill them with an autoclave). He then founded a startup (Ambergene) with the hopes of discovering ancient antibiotics (this was back during the natural ........ Read more »
Ratcliff, W., Hawthorne, P., Travisano, M., & Denison, R. (2009) When Stress Predicts a Shrinking Gene Pool, Trading Early Reproduction for Longevity Can Increase Fitness, Even with Lower Fecundity. PLoS ONE, 4(6). DOI: 10.1371/journal.pone.0006055
Cano, R., & Borucki, M. (1995) Revival and identification of bacterial spores in 25- to 40-million-year-old Dominican amber. Science, 268(5213), 1060-1064. DOI: 10.1126/science.7538699
Autoimmune diseases are troubling, and often frustrating and painful for health care practitioners and patients. As far as I know, celiac disease is the only autoimmune disorder with a specific and identified trigger: the protein gluten. It has also been pointed out that the incidence of Celiac Disease, the formal name for gluten-triggered autoimmune reactions in the bowel, appears to have been increasing. Some have claimed that humans are not adapted to consumption of plant proteins like glu........ Read more »
Elliott, DE and Weinstock JV. (2009) Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths . Progress in Inflammation Research, 149-178. DOI: 10.1007/978-3-7643-8903-1_9
Pinier M, Fuhrmann G, Verdu E, & Leroux JC. (2010) Prevention measures and exploratory pharmacological treatments of celiac disease. The American journal of gastroenterology, 105(12), 2551. PMID: 20877349
López-Serrano P, Pérez-Calle JL, Pérez-Fernández MT, Fernández-Font JM, Boixeda de Miguel D, & Fernández-Rodríguez CM. (2010) Environmental risk factors in inflammatory bowel diseases. Investigating the hygiene hypothesis: a Spanish case-control study. Scandinavian journal of gastroenterology, 45(12), 1464-71. PMID: 20704469
I hope all of you had a warm and happy holiday season! I’ve missed you! It...... Read more »
Lu, J., Unwin, D., Deeming, D., Jin, X., Liu, Y., & Ji, Q. (2011) An Egg-Adult Association, Gender, and Reproduction in Pterosaurs. Science, 331(6015), 321-324. DOI: 10.1126/science.1197323
There's a lot of talk, much of it rather speculative, about "neuroethics" nowadays.But there's one all too real ethical dilemma, a direct consequence of modern neuroscience, that gets very little attention. This is the problem of incidental findings on MRI scans.An "incidental finding" is when you scan someone's brain for research purposes, and, unexpectedly, notice that something looks wrong with it. This is surprisingly common: estimates range from 2–8% of the general population. It will hap........ Read more »
Cramer SC, Wu J, Hanson JA, Nouri S, Karnani D, Chuang TM, & Le V. (2011) A system for addressing incidental findings in neuroimaging research. NeuroImage. PMID: 21224007
Thomas Metzinger wrote an outline of his book, ‘Being No One’, which puts his theory of consciousness in a very brief, compact form. He puts forward a list of constraints that any system must have to be conscious. The first three constrains gives a simple form of consciousness which he then elaborates with further constrains. [...]... Read more »
Thomas Metzinger. (2005) Precis of - Being No One. Psyche - An Interdisciplinary Journal of Research on Consciousness, 11(5). info:/
PVC may have played a big part in our evolution... But, no I'm not talking about polyvinyl chloride (sorry to dissapoint!), I'm talking about the Planctomycetes, Verrucomicrobia, Chlamydiae (PVC) bacterial superphylum. And I'm talking waaaay back, when the Chlamydiae were much more innocent and hadn't got into that whole sexually transmitted disease scene.In a Science article, Devos and Reynaud discuss the possibility that that The PVC bugs, which appear to be a monophyletic group forming their ........ Read more »
Fuerst JA, & Webb RI. (1991) Membrane-bounded nucleoid in the eubacterium Gemmatata obscuriglobus. Proceedings of the National Academy of Sciences of the United States of America, 88(18), 8184-8. PMID: 11607213
Lonhienne, T., Sagulenko, E., Webb, R., Lee, K., Franke, J., Devos, D., Nouwens, A., Carroll, B., & Fuerst, J. (2010) From the Cover: Endocytosis-like protein uptake in the bacterium Gemmata obscuriglobus. Proceedings of the National Academy of Sciences, 107(29), 12883-12888. DOI: 10.1073/pnas.1001085107
The book manuscript I’m currently working on for Hampton Press involves an updated section on social media. When I started my dissertation research in 2003, websites were all the rage – and the only rage. Now, organizations of all types … Continue reading →... Read more »
Thackeray, R., & Hunter, M. (2010) Empowering Youth: Use of Technology in Advocacy to Affect Social Change. Journal of Computer-Mediated Communication, 15(4), 575-591. DOI: 10.1111/j.1083-6101.2009.01503.x
Insomnia is something all of us struggle with from time to time. Not being able to get off to sleep is perhaps one of the most frustrating and loathsome things in the world (second only to an itchy back).
Many of us resort to herbal or medical remedies. If you had to choose one, which would you go for? Did you realise though that the colour of your remedy has an effect!? Read on to find out why blue is best…... Read more »
Moerman DE, & Jonas WB. (2002) Deconstructing the placebo effect and finding the meaning response. Annals of internal medicine, 136(6), 471-6. PMID: 11900500
Today, we’re going back to my old frienemy, the arXiv blog. Even though I tend to beat up on it quite a bit, the preprint archive does have some interesting papers, even if the only interesting part about them is shredding them for a skeptical post. Then again, this sort of constant criticism of scientific [...]... Read more »
reposted from: http://info.cancerresearchuk.org/news/archive/cancernews/2011-01-19-Smoking-to-blame-for-majority-of-gender-gap-in-deaths-?rss=truecrabsallover highlights, key points, comments / links.Wednesday 19 January 2011Smoking accounts for up to 60 per cent of the gender gap in death rates across Europe, according to a new study by scientists at the MRC/CSO Social and Public Health Sciences Unit in Glasgow.The study authors set out to investigate death ra........ Read more »
McCartney, G., Mahmood, L., Leyland, A., Batty, G., & Hunt, K. (2011) Contribution of smoking-related and alcohol-related deaths to the gender gap in mortality: evidence from 30 European countries. Tobacco Control. DOI: 10.1136/tc.2010.037929
The shadow of symmetry haunts physics. Symmetry is invoked to understand nature concisely, but broken symmetry is invoked to understand nature completely. Physics is filled with examples of shattered symmetries: there is more matter than antimatter, neutrinos only come in the left handed spin flavor, and quantum processes break symmetries constantly, but nature also violates symmetry in chemistry and biology in a very clever manner. Chemistry and biology are subjects I do no normally touch ........ Read more »
Robert N. Compton, Richard M. Pagni, & Volume 48, 2002, Pages 219-261. (2002) The chirality of biomolecules. Advances In Atomic, Molecular, and Optical Physics, 219-261. info:/
So, in the previous installment, we introduced the "Loudest Voice Prevails" principle, which describes the evolutionarily stable pattern of gene expression at an imprinted locus where there is an intragenomic conflict over the total level of gene expression. Basically, the allele that favors lower expression becomes transcriptionally silenced. Expression from the other allele (the "louder" voice) evolves to the level that maximizes its inclusive fitness. In this sense, the active allele at an im........ Read more »
Kondoh, M., & Higashi, M. (2000) Reproductive Isolation Mechanism Resulting from Resolution of Intragenomic Conflict. The American Naturalist, 156(5), 511-518. DOI: 10.1086/303409
by Kambiz Kamrani in Anthropology.net
I got some archaeobotany for you to start your weekend off right with — a new open access study in PNAS announces a genome wide association of 8,000 years of grape domestication, spanning the Eastern Caucasus to Western Europe. Lead … Continue reading →... Read more »
Myles, S., Boyko, A., Owens, C., Brown, P., Grassi, F., Aradhya, M., Prins, B., Reynolds, A., Chia, J., Ware, D.... (2011) Genetic structure and domestication history of the grape. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1009363108
Sometimes I'm going to write about rare cancers or blood diseases and sometimes I’m going to write about bad breath. That’s just the way I roll.
Halitosis literally means “condition of the breath” and has many causes and just as many home remedies. Original therapies (and by original I mean 1550 BC) like heavily herb infused wines didn’t remove the bad breath but like mints and other modern treatments they just attempted to cover the bad smell with something more pleasant.
Halitos........ Read more »
Suarez FL, Furne JK, Springfield J, & Levitt MD. (2000) Morning breath odor: influence of treatments on sulfur gases. Journal of dental research, 79(10), 1773-7. PMID: 11077993
Wow, the new year is off to a great start in GPCR structural biology: Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, & Kobilka BK (2011). Structure of a [...]... Read more »
Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS.... (2011) Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature, 469(7329), 175-80. PMID: 21228869
Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK.... (2011) Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature, 469(7329), 236-40. PMID: 21228876
Warne T, Moukhametzianov R, Baker JG, Nehmé R, Edwards PC, Leslie AG, Schertler GF, & Tate CG. (2011) The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor. Nature, 469(7329), 241-4. PMID: 21228877
Gene variants make anti-craving drugs a hit-or-miss affair.
Rather than taking on another broad hunt for the genes controlling the expression of alcoholism, noted addiction researcher Dr. Bankole Johnson and co-workers at the Department of Psychiatry and Neurobehavioral Sciences at the University of Virginia took a different tack. The researchers focused, instead, on investigating whether genetic variations among alcoholics might affect their responses to a specific anti-craving medication.
T........ Read more »
Johnson, B., Ait-Daoud, N., Seneviratne, C., Roache, J., Javors, M., Wang, X., Liu, L., Penberthy, J., DiClemente, C., & Li, M. (2011) Pharmacogenetic Approach at the Serotonin Transporter Gene as a Method of Reducing the Severity of Alcohol Drinking. American Journal of Psychiatry. DOI: 10.1176/appi.ajp.2010.10050755
dbSNP is NCBI’s catalog of DNA variation. While the SNP in the name implies a focus on Single Nucleotide Polymorphisms, dbSNP is far more comprehensive and includes length variants, mutations, and a plethora of annotations that characterize over 75...
[[ This is a content summary only. Visit my website for full links, other content, and more! ]]... Read more »
Sherry ST, Ward M, & Sirotkin K. (1999) dbSNP-database for single nucleotide polymorphisms and other classes of minor genetic variation. Genome research, 9(8), 677-9. PMID: 10447503
As I approach my third trimester, I’m becoming a bit of an omega-3 fiend. The unsaturated fatty acids have not only been tied to lower heart disease risk in adults, but they have also been shown to boost fetal brain development, especially when consumed in the final few months of pregnancy. Given that I’m not much of a cold water fish fan—the thought of chewing a mouthful of sardines makes me want to gag—I’ve been looking into how else to get them, and what I’ve uncov........ Read more »
PSOTA, T., GEBAUER, S., & KRISETHERTON, P. (2006) Dietary Omega-3 Fatty Acid Intake and Cardiovascular Risk. The American Journal of Cardiology, 98(4), 3-18. DOI: 10.1016/j.amjcard.2005.12.022
JACOBSON, J., JACOBSON, S., MUCKLE, G., KAPLANESTRIN, M., AYOTTE, P., & DEWAILLY, E. (2008) Beneficial Effects of a Polyunsaturated Fatty Acid on Infant Development: Evidence from the Inuit of Arctic Quebec. The Journal of Pediatrics, 152(3), 356-3640. DOI: 10.1016/j.jpeds.2007.07.008
The Government announced this week the list... Read more »
As a preface to a post about 2011 research by many of the same scientists, this post discusses previous work on music and the emotion that led to the recently published dopamine study.... Read more »
Salimpoor, V., Benovoy, M., Longo, G., Cooperstock, J., & Zatorre, R. (2009) The Rewarding Aspects of Music Listening Are Related to Degree of Emotional Arousal. PLoS ONE, 4(10). DOI: 10.1371/journal.pone.0007487
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