For as long as I have been in pain research (and long before I ever even thought about pain research) the topic of mechanically-gated ion channels has been a huge deal. The reasons are simple: 1) We obtain information about … Continue reading →... Read more »
Coste, B., Mathur, J., Schmidt, M., Earley, T., Ranade, S., Petrus, M., Dubin, A., & Patapoutian, A. (2010) Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels. Science. DOI: 10.1126/science.1193270
by Peter Janiszewski, Ph.D. in Obesity Panacea
So what have we learned thus far?
1. About a third of obese individuals fail to exhibit the metabolic complications commonly attributed to excess weight.
2. These same individuals also seem to be at the same relative risk of diabetes and cardiovascular disease as equally healthy, but lean individuals.
3. Nevertheless, despite being metabolically healthy, some evidence suggests that excess weight may put such obese individuals at risk for early mortality due to other, non-metabolic, factors.
4. T........ Read more »
Janiszewski, P., & Ross, R. (2010) Effects of Weight Loss Among Metabolically Healthy Obese Men and Women. Diabetes Care, 33(9), 1957-1959. DOI: 10.2337/dc10-0547
This was a follow up to a nationwide survey of GPs in Scotland completed in 2000. They used a similar questionnaire to the original study and sent it to a random sample of one in four Scottish GPs (n=1065). After a poor initial response they sent an abbreviated questionnaire on the key areas from the [...]... Read more »
Matheson C, Porteous T, van Teijlingen E, & Bond C. (2010) Management of drug misuse: an 8-year follow-up survey of Scottish GPs. The British journal of general practice : the journal of the Royal College of General Practitioners, 60(576), 517-20. PMID: 20594442
Glucosamine and chondroitin do not work in alleviating the pain of osteoarthritis (of hip or knee), other than perhaps as an expensive placebo that sufferers who do gain some relief daren’t stop paying for. A new meta analysis of 10 trials amounting to 3803 patients has been carried out. On a 10 cm visual analogue [...]... Read more »
Wandel, S., Juni, P., Tendal, B., Nuesch, E., Villiger, P., Welton, N., Reichenbach, S., & Trelle, S. (2010) Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ, 341(sep16 2). DOI: 10.1136/bmj.c4675
Predation is a key driver of biological systems over both ecological and evolutionary timescales. Thus, to understand our role as Homo sapiens within this evolutionary framework we must look to the animal kingdom to find our place. This is important for anyone following an evolutionary eating plan as it gives our species an ecological context, which we can consider when making choices about our lifestyle and diet. In the latest edition of Behavioral Ecology, Shultz & Finlayson utilised a range o........ Read more »
Shultz, S., & Finlayson, L. (2010) Large body and small brain and group sizes are associated with predator preferences for mammalian prey. Behavioral Ecology, 21(5), 1073-1079. DOI: 10.1093/beheco/arq108
Just how special is the human brain? Compared to other mammals, the thing that stands out most is the size of the cerebral cortex – the thick sheet of cells on the outside of the brain, which is so expanded in humans that it has to be folded in on itself in order to fit inside the skull. The cortex is the seat of higher brain functions, the bit of the brain we see with, hear with, think with. In particular, one of its main functions is association – bringing sensory information together ........ Read more »
Tomer R, Denes AS, Tessmar-Raible K, & Arendt D. (2010) Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium. Cell, 142(5), 800-9. PMID: 20813265
Isotope geochemistry is useful for so many things that its application to fetal and maternal health can be overlooked. However, this does not diminish the value of isotopic studies to this field. Consider, for example, the groundbreaking ‘Russian Bride’* experiments of Gulson et al. Determining calcium loss and lead exposure in pregnant women is not easy. Most of the bodies calcium is stored ... Read more »
GULSON, B., MIZON, K., KORSCH, M., PALMER, J., & DONNELLY, J. (2003) Mobilization of lead from human bone tissue during pregnancy and lactation—a summary of long-term research. The Science of The Total Environment, 303(1-2), 79-104. DOI: 10.1016/S0048-9697(02)00355-8
Earlier this week I expressed some concern for a new health campaign by Hershey and the American Dietetic Association. The campaign website is now launched as of Wednesday. Among my initial concerns that the number of people that will be … Continue reading →... Read more »
Provencher V, Polivy J, & Herman CP. (2009) Perceived healthiness of food. If it's healthy, you can eat more!. Appetite, 52(2), 340-4. PMID: 19071169
Polivy J, Coleman J, & Herman CP. (2005) The effect of deprivation on food cravings and eating behavior in restrained and unrestrained eaters. The International journal of eating disorders, 38(4), 301-9. PMID: 16261600
Ferriday D, & Brunstrom JM. (2008) How does food-cue exposure lead to larger meal sizes?. The British journal of nutrition, 100(6), 1325-32. PMID: 18466651
Freeland-Graves, J. (2002) Position of The American Dietetic Association Total Diet Approach to Communicating Food And Nutrition Information. Journal of the American Dietetic Association, 102(1), 100-108. DOI: 10.1016/S0002-8223(02)90030-1
Dufour MC. (2001) If you drink alcoholic beverages do so in moderation: what does this mean?. The Journal of nutrition, 131(2S-1). PMID: 11160585
Egan BM, Laken MA, Donovan JL, & Woolson RF. (2010) Does dark chocolate have a role in the prevention and management of hypertension?: commentary on the evidence. Hypertension, 55(6), 1289-95. PMID: 20404213
After presenting to the FDA Advisory Committee on Sibutramine on Wednesday, I had to hurry off to join the faculty of the 2nd SCOPE Summer School on the Management of the Obese Patient, in Cambridge, UK.
Fortunately, I was able to follow most of yesterday’s FDA advisory meeting on the 5-HT2c antagonist lorcaserin (Lorqess), another obesity [...]... Read more »
Smith SR, Weissman NJ, Anderson CM, Sanchez M, Chuang E, Stubbe S, Bays H, Shanahan WR, & Behavioral Modification and Lorcaserin for Overweight and Obesity Management (BLOOM) Study Group. (2010) Multicenter, placebo-controlled trial of lorcaserin for weight management. The New England journal of medicine, 363(3), 245-56. PMID: 20647200
Photo from Encyclopaedia Britannica.
Light. It’s all around and is the foundation of much of planet. Plants on land or in the shallow seas use the power of light to catalyze a cascade of interactions that ultimately result in the foundation of our planet. Even in the deep sea the products of light find their way [...]... Read more »
Branham, M., & Wenzel, J. (2003) The origin of photic behavior and the evolution of sexual communication in fireflies (Coleoptera: Lampyridae). Cladistics, 19(1), 1-22. DOI: 10.1111/j.1096-0031.2003.tb00404.x
J.E. Lloyd. (1997) Firefly mating ecology, selection and evolution. In: Choe, J.C., Crespi, B.J. (Eds.), Evolution of Mating Systems in Insects and Arachnids. Cambridge University Press, London, 184-192. DOI: 10.1017/CBO9780511721946.011
Stanger-Hall, K., Lloyd, J., & Hillis, D. (2007) Phylogeny of North American fireflies (Coleoptera: Lampyridae): Implications for the evolution of light signals. Molecular Phylogenetics and Evolution, 45(1), 33-49. DOI: 10.1016/j.ympev.2007.05.013
Woods WA Jr, Hendrickson H, Mason J, & Lewis SM. (2007) Energy and predation costs of firefly courtship signals. The American naturalist, 170(5), 702-8. PMID: 17926292
So this week seems to be turning out to be cooperation week. We talked about cooperative behavior of the proteins that make up the cytoskeleton on Monday, cooperation in breeding behavior in birds on Wednesday, and now it’s time to talk about cooperative behavior in bacteria. If only I’d planned it in advance. Ah well; [...]... Read more »
An unusually gripping genetics paper from Biological Psychiatry: Pagnamenta et al.The authors discuss a family where two out of the three children were diagnosed with autism. In 2009, they detected a previously unknown copy number variant mutation in the two affected brothers: a 594 kb deletion knocking out two genes, called DOCK4 and IMMP2L.Yet this mutation was also carried by their non-autistic mother and sister, suggesting that it wasn't responsible for the autism. The mother's side of the f........ Read more »
Pagnamenta, A., Bacchelli, E., de Jonge, M., Mirza, G., Scerri, T., Minopoli, F., Chiocchetti, A., Ludwig, K., Hoffmann, P., & Paracchini, S. (2010) Characterization of a Family with Rare Deletions in CNTNAP5 and DOCK4 Suggests Novel Risk Loci for Autism and Dyslexia. Biological Psychiatry, 68(4), 320-328. DOI: 10.1016/j.biopsych.2010.02.002
Have you been in a situation where you are the first to detect a cardiac murmur in a patient? If you are hearing it in a busy, loud Emergency Department, I find that it's at least a grade III. Should you order an echocardiogram for further outpatient evaluation? It depends on the grade and characteristic of the murmur, in addition to the patient's symptoms. For instance, all diastolic murmurs require an echo. There is a useful ACC/AHA algorithm which helps you decide.Thanks to Amy Kinard, an Eme........ Read more »
, ., Bonow, R., Carabello, B., Chatterjee, K., de Leon, A., Faxon, D., Freed, M., Gaasch, W., Lytle, B., Nishimura, R.... (2008) 2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to. Circulation, 118(15). DOI: 10.1161/CIRCULATIONAHA.108.190748
Evolutionary Anthropology has a nice paper summarizing the history of domestic cattle, based on the latest molecular marker data. Unusually, the authors at least attempt a flowing account of the origin and spread of a domesticated species, and even more unusually actually achieve it in places. Alas, the details of haplogroups and mtDNA vs Y-chromosome [...]... Read more »
Ajmone-Marsan, P., Garcia, J., & Lenstra, J. (2010) On the origin of cattle: How aurochs became cattle and colonized the world. Evolutionary Anthropology: Issues, News, and Reviews, 19(4), 148-157. DOI: 10.1002/evan.20267
Reading the following passage might lead you to exclaim: “What an incredible storyteller J.R.R. Tolkien was!” or more likely, “What a visionary evolutionary biologist J.R.R. Tolkien was!” depending on how you interpret it of course. “He was Gollum—as dark as darkness, except for two big round pale eyes in his thin face. He had a [...]... Read more »
Yoshizawa M, Gorički S, Soares D, & Jeffery WR. (2010) Evolution of a Behavioral Shift Mediated by Superficial Neuromasts Helps Cavefish Find Food in Darkness. Current biology : CB. PMID: 20705469
[Wherein our hero examines the influence of colour on competitiveness for an upcoming tournament. Repost] I’ll need to provide a little context: For the last 10 or 11 years I have studies Taekwon-Do. No, no, not the stuff you see in the Olympics – but a real martial art, you know [where they use their hands [...]... Read more »
Frank, M., & Gilovich, T. (1988) The dark side of self- and social perception: Black uniforms and aggression in professional sports. Journal of Personality and Social Psychology, 54(1), 74-85. DOI: 10.1037/0022-35184.108.40.206
Hill, R., & Barton, R. (2005) Psychology: Red enhances human performance in contests. Nature, 435(7040), 293-293. DOI: 10.1038/435293a
It was a rare bit of good news. India’s Forest Ministry recently announced that the nation’s forests had expanded by nearly 5% over the last decade – an impressive gain in a country that had lost 80% of its native trees. But three researchers are now challenging that survey, saying it masked continuing forest losses […] Read More »... Read more »
Puyravaud, J., Davidar, P., & Laurance, W. (2010) POLICY PERSPECTIVE: Cryptic destruction of India's native forests. Conservation Letters. DOI: 10.1111/j.1755-263X.2010.00141.x
Most Nutritional Therapists are comfortable in the concept and application of concentrated essential fatty acids especially fish oils as a means of altering abnormal inflammatory pathways in the body. Some EFA’s are perceived to be anti-inflammatory and others pro-inflammatory. Whilst the simplistic dichotomy of interpretation (Omega 3 Anti/Omega 6 Pro) has kept many a student [...]... Read more »
Oh da Y, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, & Olefsky JM. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell, 142(5), 687-98. PMID: 20813258
Schenk, S., Saberi, M., & Olefsky, J. (2008) Insulin sensitivity: modulation by nutrients and inflammation. Journal of Clinical Investigation, 118(9), 2992-3002. DOI: 10.1172/JCI34260
Ford, E. (2002) Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey. JAMA: The Journal of the American Medical Association, 287(3), 356-359. DOI: 10.1001/jama.287.3.356
This definition of supply risk views the supply chain from end to end, acknowledging that what you purchase as a supply, in the the end will wind up in some customer's hand, to which you may be liable, if your product or service is faulty [ ... ]... Read more »
A new study identifies a likely cause of rapid degeneration in some Alzheimer's patients. The results of this study may lead to improved treatment.
But first, let's look at the method used in this study, because that may be almost as important as a development. And for this, we will use a sports analogy. Read the rest of this post... | Read the comments on this post...... Read more »
Cruchaga, Carlos, Kauwe, John, Mayo, Kevin, Spiegel, Noah, Bertelsen, Sarah, & Et.Al. (2010) SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer’s Disease . PLoS Genetics, 6(9). info:/
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.