Post List

  • February 26, 2009
  • 09:38 PM

Competing prediction rules for DVT

by Robert Badgett in ClinDx

I appreciate the AMUSE group's efforts at creating a less subjective prediction rule for DVT and look forward to a direct comparison of the current versions of both rules.... Read more »

Büller HR, Ten Cate-Hoek AJ, Hoes AW, Joore MA, Moons KG, Oudega R, Prins MH, Stoffers HE, Toll DB, van der Velde EF.... (2009) Safely ruling out deep venous thrombosis in primary care. Annals of internal medicine, 150(4), 229-35. PMID: 19221374  

  • February 26, 2009
  • 09:00 PM

A point mutation remodels a binding interface

by Michael Clarkson in Conformational Flux

Decades of studies involving extensive mutagenesis of proteins and protein domains have impressed on us the idea that the folded tertiary structures of proteins are fairly resilient. While a particular mutation may abolish function by directly ablating a key chemical group, it is rare for a single mutation, or even a group of several mutations, to significantly change the overall conformation of a folded polypeptide chain. When a major change does result, it often takes the form of complete dena........ Read more »

  • February 26, 2009
  • 06:13 PM

TRB: Objects in the Minds of Men and Monkeys

by Michael in dlPFC

Neuroscience research using monkeys promises to balance the precision of direct investigation into neuronal activity with the relevance of increasingly complex behaviors approaching human cognition.  Despite our captivation with fMRI, it cannot match the scientific rigor of single-cell recordings, which, for obvious reasons, can only be performed on humans in very rare circumstances (such as [...]... Read more »

  • February 26, 2009
  • 04:18 PM

Erasing Fear with Propranolol

by Shaheen Lakhan in Brain Blogger

Emotional memories last forever. Evolutionarily speaking, it is advantageous to remember the important events in life. However, some memories become harmful or maladaptive, such as in post-traumatic stress disorder, phobias, and some addictions. Psychologists and psychiatrists have tried for more than a century to erase these detrimental memories through pharmacological, psychological, and behavioral treatments, with [...]... Read more »

  • February 26, 2009
  • 03:49 PM

What to do when you review?

by Lab Lemming in Lounge of the Lab Lemming

Peer review is one of those exercises that is vitally important to the promulgation of scientific knowledge. It is also one for which we get absolutely no training. and if that is not bad enough, it is cloaked in unnecessary secrecy and anonymity. The way it works is this:In between irate meetings, technical emergencies, slipping deadlines, and normal workload, you get an unsolicited email... Read more »

  • February 26, 2009
  • 03:45 PM

What is a visual expert?

by Dave Munger in Cognitive Daily

Last week, we presented research by Miranda Scolari's team about visual expertise and visual short-term memory. Their conclusion: "experts" don't have a larger visual memory capacity than non-experts, they just have the ability to process more details. Scolari's team was working under the assumption that all humans (or at least all the students in their experiment) are face-recognition experts.

It's true: we're amazingly good at recognizing faces we've seen before. Think how much easier it is........ Read more »

Kim M. Curby, Kuba Glazek, & Isabel Gauthier. (2009) A visual short-term memory advantage for objects of expertise. Journal of Experimental Psychology: Human Perception and Performance, 35(1), 94-107. DOI: 10.1037/0096-1523.35.1.94  

  • February 26, 2009
  • 03:45 PM

Why be good? Imitation and migration might explain it

by Tom Rees in Epiphenom

Just before Christmas, the American Humanist Association ran bus ads with the slogan 'Just be good for goodness sake'.Yeah right.From an evolutionary standpoint, pure selfless altruism - doing something that costs you but only benefits someone else - doesn't make sense. Altruism is usually explained by kinship, or because it enhances reputation, or because it avoids punishment. People are good because they get something out of it.But what about anonymous encounters? Say if I were to meet in a da........ Read more »

  • February 26, 2009
  • 01:59 PM

Tracking flu through online search queries.

by Janet D. Stemwedel in Adventures in Ethics and Science (Sb)

This morning, I was made aware (by my better half) of the existence of Google Flu Trends. This is a project by Google to use search terms to create a model of flu activity across the United States. Indeed, the results have been good enough that they were reported in a Letter in Nature [1] back in November 2008 (but with a correction published online 19 February 2009). From that letter: Read the rest of this post... | Read the comments on this post...... Read more »

Jeremy Ginsberg, Matthew H. Mohebbi, Rajan S. Patel, Lynnette Brammer, Mark S. Smolinski, & Larry Brilliant. (2008) Detecting influenza epidemics using search engine query data. Nature, 457(7232), 1012-1014. DOI: 10.1038/nature07634  

  • February 26, 2009
  • 12:23 PM

Large Area, Few-Layer Graphene Films on Arbitrary Substrates by Chemical Vapor Deposition

by Rob W. in Graphene Literature Reviews

Alfonso Reina, Xiaoting Jia, John Ho, Daniel Nezich, Hyungbin Son, Vladimir Bulovic, Mildred S. Dresselhaus, Jing Kong (2009). Large Area, Few-Layer Graphene Films on Arbitrary Substrates by Chemical Vapor Deposition Nano Letters, 9 (1), 30-35 DOI: 10.1021/nl801827vA very nice CVD paper where the graphene is transferred to a device friendly substrate (SiO2). The authors used chemical vapor deposition (CVD, also discussed here) on a polycrystalline nickel film, pumping hydrogen and methane gases........ Read more »

Alfonso Reina, Xiaoting Jia, John Ho, Daniel Nezich, Hyungbin Son, Vladimir Bulovic, Mildred S. Dresselhaus, & Jing Kong. (2009) Large Area, Few-Layer Graphene Films on Arbitrary Substrates by Chemical Vapor Deposition. Nano Letters, 9(1), 30-35. DOI: 10.1021/nl801827v  

  • February 26, 2009
  • 11:00 AM

Perhaps I should start asking Acacia trees for relationship advice?

by Cheshire in Cheshire

Acacia trees and ants have an interesting mutualistic relationship which is frequently used as a textbook example of a mutualism. The trees offer the ants hollow thorns in which to live and food to eat, and the ants protect the tree from herbivores, both insects and large mammals as well as vines which would overcrowd [...]... Read more »

  • February 26, 2009
  • 10:57 AM

Micro RNAs and cancer

by Cancer Research UK in Cancer Research UK - Science Update

Predicting the future is a tricky business, and spotting trends in the world of science is no exception. And because of the slow and careful nature of research, exciting new fields of interest take years to emerge, rather than springing up overnight.

One relatively new – and certainly exciting – area of cancer research is the [...]... Read more »

Jun Lu, Gad Getz, Eric A. Miska, Ezequiel Alvarez-Saavedra, Justin Lamb, David Peck, Alejandro Sweet-Cordero, Benjamin L. Ebert, Raymond H. Mak, Adolfo A. Ferrando.... (2005) MicroRNA expression profiles classify human cancers. Nature, 435(7043), 834-838. DOI: 10.1038/nature03702  

Amanda Dixon-McIver, Phil East, Charles A. Mein, Jean-Baptiste Cazier, Gael Molloy, Tracy Chaplin, T. Andrew Lister, Bryan D. Young, & Silvana Debernardi. (2008) Distinctive Patterns of MicroRNA Expression Associated with Karyotype in Acute Myeloid Leukaemia. PLoS ONE, 3(5). DOI: 10.1371/journal.pone.0002141  

Charles H. Lawrie, Shira Gal, Heather M. Dunlop, Beena Pushkaran, Amanda P. Liggins, Karen Pulford, Alison H. Banham, Francesco Pezzella, Jacqueline Boultwood, James S. Wainscoat.... (2008) Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. British Journal of Haematology, 141(5), 672-675. DOI: 10.1111/j.1365-2141.2008.07077.x  

Kathryn A. O'Donnell, Erik A. Wentzel, Karen I. Zeller, Chi V. Dang, & Joshua T. Mendell. (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature, 435(7043), 839-843. DOI: 10.1038/nature03677  

Raquel Díaz, Javier Silva, José M. García, Yolanda Lorenzo, Vanesa García, Cristina Peña, Rufo Rodríguez, Concepción Muñoz, Fernando García, Félix Bonilla.... (2008) Deregulated expression of miR-106a predicts survival in human colon cancer patients. Genes, Chromosomes and Cancer, 47(9), 794-802. DOI: 10.1002/gcc.20580  

Jan Krützfeldt, Nikolaus Rajewsky, Ravi Braich, Kallanthottathil G. Rajeev, Thomas Tuschl, Muthiah Manoharan, & Markus Stoffel. (2005) Silencing of microRNAs in vivo with ‘antagomirs’. Nature, 438(7068), 685-689. DOI: 10.1038/nature04303  

  • February 26, 2009
  • 10:07 AM

Taking a closer look at child sexual abuse

by Danny McCaslin in The Phrenologist's Notebook

Each year, approximately 150,000-200,000 children are sexually abused, 70-80% of those cases involve a family member or a friend of the family that the child knows, including older children. It’s an appalling proposition to anyone who wants to work in the treatment of mental disorders. The people that we are supposed to trust, the “in [...]... Read more »

Frazier, K.N., West-Olatunji, C.A., St Juste, S., Goodman, R.D. (2009) Transgenerational Trauma and Child Sexual Abuse: Reconceptualizing Cases Involving Young Survivors of CSA. Journal of Mental Health Counseling, 31(1), 22-33.

  • February 26, 2009
  • 09:00 AM

Dreaming of inactivated poliovirus vaccine

by vrr in virology blog

The World Health Organization’s global polio eradication effort uses the live, attenuated poliovirus vaccines developed by Albert Sabin. When the eradication program was announced in 1988, the goal was to eliminate global poliomyelitis, then cease immunization with poliovirus at some point in the future. In 2002 an outbreak of polio in the Dominican Republic sent [...]... Read more »

  • February 26, 2009
  • 08:30 AM

Tricking wasps

by Zen Faulkes in NeuroDojo

Orchids are lovely flowers and if you think they’re just a bit sexy, you're not alone. In fact, for some wasps, they’re very sexy. As sexy as any female wasp.It’s well known that flowers use many methods to attract insect pollinators. Many flowers have nectar. Some smell horrible, and are pollinated by flies and other insects that tend to feed off dead things. And some look like female insects, and deposit pollen on males when they come into investigate. What this paper by Anne Gaskett and........ Read more »

A. C. Gaskett, C. G. Winnick, & M. E. Herberstein. (2008) Orchid Sexual Deceit Provokes Ejaculation. The American Naturalist, 171(6). DOI: 10.1086/587532  

  • February 26, 2009
  • 05:20 AM


by Adam Yates in Dracovenator

Photo (Octavio Mateus) and reconstruction (from the paper) of the new stegosaur Miragaia longicollum.Once again I'm late to the party. Miragaia longicollum is the newly published, long-necked sauropod mimicing stegosaur from the Late Jurassic of Portugal that was featured in loads of blogs yesterday. Attendees of the SVP annual meeting may have actually caught the reconstruction of Miragaia way back in 2007, in Austin. Even though it was only up on screen for a short time, the crazy long neck wa........ Read more »

  • February 26, 2009
  • 03:30 AM

Cooperation from selfishness?

by Jeremy Yoder in Denim and Tweed

This week's PNAS has another (open access!) paper taking a crack at the problem of how cooperation can evolve. The authors create a world where cooperation arises spontaneously in a population of selfish individuals by modeling a fundamental human drive: the desire for a good neighborhood.

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Photo by Jeff Bauche.Helbing and Yu set up........ Read more »

  • February 26, 2009
  • 02:00 AM

‘Payment by outcome’ in pain management

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

Today I was informed that a major purchaser of pain management services was preparing to ‘move to payment by outcome’.  What does that mean?

Well, over the past few weeks and months I’ve been thinking about what the major influences are on health care practice.  Is it ‘the evidence’? Is it patient need?  Is it patient [...]... Read more »

R. Mannion, & H. T O Davies. (2008) Payment for performance in health care. BMJ, 336(7639), 306-308. DOI: 10.1136/bmj.39463.454815.94  

  • February 26, 2009
  • 12:03 AM

Life in the clouds?

by Invader Xan in Supernova Condensate

As a lot of people will know by now, the human race is officially going back to Jupiter and its moons. It’s currently scheduled to get there by about 2026. I’m seriously looking forward to it, myself. There’s an awful lot about our friendly neighbourhood giant that we still don’t really understand. In honour of this, I decided to take a look at a classic paper written by Carl Sagan and Edwin Salpeter on the fascinating possibility of life and potential ecologies on a hulk........ Read more »

  • February 26, 2009
  • 12:00 AM

Eyes are not centered optical systems...

by Pablo Artal in Optics confidential

The different optical components of the eye, the cornea and the crystalline lens are not properly aligned with the area of the retina (the fovea) providing the highest spatial resolution. Some information on this issue and a description of a new instrument to measure eye misalgnment is presented...... Read more »

J. Tabernero, A. Benito, V. Nourrit, and P. Artal. (2006) Instrument for measuring the misalignments of ocular surfaces. Optics Express, 10945-10956.

  • February 25, 2009
  • 11:22 PM

DARTS a valuable concise method to evaluate health information online

by Dr Shock in Dr Shock MD PhD

The web is often used to find medical information. An increasing number of individuals, companies and other stakeholders have their own websites. The content of these websites is largely unregulated and the enquirer has no way of telling whether the information is reliable. This makes it impossible to make an informed decision. The information found [...]... Read more »

Ulla Närhi, Marika Pohjanoksa-Mäntylä, Anna Karjalainen, Johanna K. Saari, Hannes Wahlroos, Marja S. Airaksinen, & Simon J. Bell. (2008) The DARTS tool for assessing online medicines information. Pharmacy World , 30(6), 898-906. DOI: 10.1007/s11096-008-9249-9  

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