High-throughput screening (HTS) is now a mainstay of drug discovery and usually the starting point for most drug discovery projects. Industry usually has a lot of resources invested in HTS and therefore needs to be aware of false positives and false negatives that could hamper useful results and lead one down an erroneous path.Among the many factors responsible for false positives in HTS, one of the most startling and important factors recently unearthed is the non-specific and potent inhibition........ Read more »
Ferreira, R., Bryant, C., Ang, K., McKerrow, J., Shoichet, B., & Renslo, A. (2009) Divergent Modes of Enzyme Inhibition in a Homologous Structure−Activity Series. Journal of Medicinal Chemistry, 2147483647. DOI: 10.1021/jm9009229
I'm sure you all know by now that restricting the amino acid methionine in the diet provides many of the health and longevity benefits of calorie restriction - in mice, at least. This is only the case for methionine, not any of the other essential amino acids that must be obtained through diet, and the resulting changes in biochemistry are not exactly the same as calorie restriction. This suggests that, for example, the loss of visceral fat associated with calorie restriction also plays an impor........ Read more »
Gomez, J., Caro, P., Sanchez, I., Naudi, A., Jove, M., Portero-Otin, M., Lopez-Torres, M., Pamplona, R., & Barja, G. (2009) Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart. Journal of Bioenergetics and Biomembranes. DOI: 10.1007/s10863-009-9229-3
Seda Dural et.al. (2008) used eye tracking combined with attractiveness ratings to explore the effect of altering waist-hip ratio and body fat levels in figures generated from 3D modeling software.
The stimuli were presented individually to 50 males and 50 females aged 18-22 (probably Turkish college students) on an LCD screen for viewing and rated for [...]... Read more »
Dural, Seda, Cetinkaya, Hakan, Gulbetekin, Evrim. (2008) The role of waist-to-hip ratio in evaluation of female physical attractiveness: Eye-tracker data. Kadinin fiziksel cekiciliinin deerlendirilmesinde bel-kalca-oraninin rolu: Goz-izleme sistemi verileri. Turk Psikoloji Dergisi, 75-88. info:/
Child abuse of any sort is difficult to understand, but the homicide of infants by caretakers is beyond most people's imagination. A new study sheds some light on who commits these acts.
... Read more »
What is it? Open Notebook means “no insider information” You lab notebook is on a wiki, out there for everyone to see. Negative results & all. You share your research process with the world as you go along. There are many shades to this process: you may share some of your data, edit it, [...]... Read more »
Hoffmann, R. (2008) A wiki for the life sciences where authorship matters. Nature Genetics, 40(9), 1047-1051. DOI: 10.1038/ng.f.217
Sagotsky, J., Zhang, L., Wang, Z., Martin, S., & Deisboeck, T. (2008) Life Sciences and the web: a new era for collaboration. Molecular Systems Biology. DOI: 10.1038/msb.2008.39
by Vincent Racaniello in virology blog
A few weeks ago I asked readers to find the errors in the following statement concerning an experimental influenza vaccine produced by Protein Sciences which involves synthesis of the viral HA protein in insect cells.
They warned that the virus could mutate during the southern hemisphere’s flu season before returning north in a more lethal form in [...]... Read more »
Ross, T., Mahmood, K., Crevar, C., Schneider-Ohrum, K., Heaton, P., & Bright, R. (2009) A Trivalent Virus-Like Particle Vaccine Elicits Protective Immune Responses against Seasonal Influenza Strains in Mice and Ferrets. PLoS ONE, 4(6). DOI: 10.1371/journal.pone.0006032
Advocates for evidence based care feel our ears perk up when we hear about a new Cochrane systematic review. Cochrane Review = Evidence! Right? Indeed, systematic reviews represent the top of the “evidence pyramid” and Cochrane systematic reviews are the gold standard for their rigor and transparency. A Cochrane review can even conclusively settle important [...]... Read more »
Ohlsson A, & Shah VS. (2009) Intrapartum antibiotics for known maternal Group B streptococcal colonization. Cochrane database of systematic reviews (Online). PMID: 19588432
Our weekly compilation of science news for the week of July 26, 2009.... Read more »
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A., Benoist, C., Shoelson, S.... (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nature Medicine. DOI: 10.1038/nm.2002
Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J., Gygi, S., & Spiegelman, B. (2009) Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex. Nature. DOI: 10.1038/nature08262
Orso, G., Pendin, D., Liu, S., Tosetto, J., Moss, T., Faust, J., Micaroni, M., Egorova, A., Martinuzzi, A., McNew, J.... (2009) Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin. Nature. DOI: 10.1038/nature08280
Page, R., Ambady, S., Holmes, W., Vilner, L., Kole, D., Kashpur, O., Huntress, V., Vojtic, I., Whitton, H., & Dominko, T. (2009) Induction of Stem Cell Gene Expression in Adult Human Fibroblasts without Transgenes. Cloning and Stem Cells, 2147483647. DOI: 10.1089/clo.2009.0015
Gentleman, E., Swain, R., Evans, N., Boonrungsiman, S., Jell, G., Ball, M., Shean, T., Oyen, M., Porter, A., & Stevens, M. (2009) Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation. Nature Materials. DOI: 10.1038/nmat2505
Child abuse of any sort is difficult to understand, but the homicide of infants by caretakers is beyond most people's imagination. A new study sheds some light on who commits these acts.Fujiwara, T., Barber, C., Schaechter, J., & Hemenway, D. (2009). Characteristics of Infant Homicides: Findings From a U.S. Multisite Reporting System PEDIATRICS, 124 (2) DOI: 10.1542/peds.2008-3675The study reports on 72 cases drawn from the National Violent Injury Statistics System. The system was developed to p........ Read more »
So if you purchase organically grown food (crops and meat) because you think they are more nutritious, then you might be disappointed to learn that there is no evidence that it is.In a huge survey of the literature on organic food from the last 50 years, the overall message is that no difference in nutritional value is to be found between organically and conventionally grown foods.  (By the ... Read more »
Dangour, A., Dodhia, S., Hayter, A., Allen, E., Lock, K., & Uauy, R. (2009) Nutritional quality of organic foods: a systematic review. American Journal of Clinical Nutrition. DOI: 10.3945/ajcn.2009.28041
Pettersson, I., & Berg, C. (2007) ENVIRONMENTALLY RELEVANT CONCENTRATIONS OF ETHYNYLESTRADIOL CAUSE FEMALE-BIASED SEX RATIOS IN XENOPUS TROPICALIS AND RANA TEMPORARIA. Environmental Toxicology and Chemistry, 26(5), 1005. DOI: 10.1897/06-464R.1
I am painfully aware of the risk we run here at the Agricultural Biodiversity Weblog of becoming single-issue bores. To a hammer, everything is a nail. And if your thing is agrobiodiversity, you’ll naturally be tempted to think that every problem can be solved by the judicious application of an agrobiodiversity thwack. How refreshing [...]... Read more »
Giller, K., Witter, E., Corbeels, M., & Tittonell, P. (2009) Conservation agriculture and smallholder farming in Africa: The heretics’ view. Field Crops Research. DOI: 10.1016/j.fcr.2009.06.017
We'll start off today's post with a quick refresher on the present state of knowledge regarding antioxidants and life span in laboratory animals. Antioxidants are compounds that neutralize oxidants, such as the reactive oxygen species produced by your mitochondria that are implicated in the damage of aging. In theory, neutralizing those damaging oxidants before they can cause harm to your cellular machinery will lead to a lesser accumulation of cellular and tissue damage over time, and thus a sl........ Read more »
Jang, Y., Perez, V., Song, W., Lustgarten, M., Salmon, A., Mele, J., Qi, W., Liu, Y., Liang, H., Chaudhuri, A.... (2009) Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. DOI: 10.1093/gerona/glp100
Everything You Know About Counterinsurgency History Is (possibly) Wrong!I find it refreshing to hear an historian analyze ideas about counterinsurgency (COIN), if only to break the monotony of listening to COIN practitioners and doctrineers analyzing history. A new article by Professor Jonathan Gumz from USMA West Point makes the point.Gumz begins by noting that a flood of new scholarship on COIN has emerged - particularly in military journals - over the past six years. Articles typically inc........ Read more »
Gumz, J. (2009) Reframing the Historical Problematic of Insurgency: How the Professional Military Literature Created a New History and Missed the Past. Journal of Strategic Studies, 32(4), 553-588. DOI: 10.1080/01402390902986972
Implicit attitudes and associations can tell us a lot about a person. It's a way to find out if they might have a racial or gender bias, and recently there has even been some work suggesting that an implicit association test can tell us whether someone is lying -- it's called the autobiographical Implicit Association Test (aIAT). Here's how it works:
Suppose you're an American soldier and you want to know if an Afghan you've captured is really a member of the Taliban, despite his assurances tha........ Read more »
Verschuere, B., Prati, V., & Houwer, J. (2009) Cheating the Lie Detector: Faking in the Autobiographical Implicit Association Test. Psychological Science, 20(4), 410-413. DOI: 10.1111/j.1467-9280.2009.02308.x
And in science this can be the biggest barrier to moving forward. If we can't show an event happening how do we know it is happening at all? Since the 1950's a large gap between what we can see under microscopes and what we can see when we crystallize things (i.e. DNA) has existed. The gap has historically been in the range of tens to hundreds of nanometers leaving many macromolecular events taking place inside every living cell on earth in a black box; inaccessible to the human eye and ther........ Read more »
Lee, J., Hong, B., Kim, W., Min, S., Kim, Y., Jouravlev, M., Bose, R., Kim, K., Hwang, I., Kaufman, L.... (2009) Near-field focusing and magnification through self-assembled nanoscale spherical lenses. Nature, 460(7254), 498-501. DOI: 10.1038/nature08173
JOHAN MERTENS, LYNDA BELADJAL, ANGELICA ALCANTARA, LIESJE FOUGNIES, DOMINIQUE VAN DER STRAETEN and JAMES S. CLEGG (2008). Survival of dried eukaryotes (anhydrobiotes) after exposure to very high temperatures Biological Journal of the Linnean Society, 93, 15-22 pdfEver since Antonie van Leeuwenhoek demonstrated the appearance of animalcules* in cultures made with previously dry dust more than 300 years ago, biologists have been getting kicks out of pushing the limits of the survivability o........ Read more »
JOHAN MERTENS, LYNDA BELADJAL, ANGELICA ALCANTARA, LIESJE FOUGNIES, DOMINIQUE VAN DER STRAETEN and JAMES S. CLEGG. (2008) Survival of dried eukaryotes (anhydrobiotes) after exposure to very high temperatures. Biological Journal of the Linnean Society, 15-22. DOI: http://www3.interscience.wiley.com/journal/119394141/abstract
I came across an interesting post in ScienceDaily – Consumer Behavior yesterday about how people draw inferences from seemingly neutral packaging features. The referenced article is by two Canadian researchers:
David Hammond and Carla Parkinson (2009). The impact of cigarette package design on perceptions of risk J Public Health (July 27, 2009)
The ScienceDaily post describes the [...]... Read more »
Hammond D, & Parkinson C. (2009) The impact of cigarette package design on perceptions of risk. Journal of public health (Oxford, England). PMID: 19636066
Color-coded diagram of a small bone bed containing at least twelve individuals of the Permian synapsid Suminia. From Frobisch and Reisz (2009)
When I hear the phrase "early human relative" I cannot help but think of an ape-like creature. Something like Sahelanthropus fits the bill nicely; it may not be a hominin but it is still a close relative from around the time that the first hominins evolved. That is why I was a bit puzzled to see MSNBC.com parroting a story written by the Discovery Chann........ Read more »
Jörg Fröbisch and Robert R. Reisz. (2009) The Late Permian herbivore Suminia and the early evolution of arboreality in terrestrial vertebrate ecosystems. Proceedings of the Royal Society B. DOI: 10.1098/rspb.2009.0911
by Jon Voisey in Angry Astronomer
The past few years, much public attention has been brought to the outskirts of our solar system by the demotion of Pluto. Love it or hate it, suddenly the Kupier Belt is getting a lot more attention than it used to. Sometimes, people even know the names of some of the objects in it. But that's only the bigguns like Quaoar and Sedna. There's many others out there, and one that gets little attention is Haumea.Haumea is only 1/3 the mass of Pluto, but is notable because of its unusual shape: It's e........ Read more »
As I have previously discussed, while erectile dysfunction can have a detrimental impact on quality of life, it also appears to foreshadow future cardiovascular disease risk (i.e. heart attack). Indeed, it is reported that men who seek medical attention for cardiovascular disease symptoms often report that their penis stopped working long before they had any signs of heart problems.
A new study, published ahead of print in the Journal of Sexual Medicine, reports for the first time that the pr........ Read more »
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