A large-scale, multi-dimensional analysis of the genomic characteristics of glioblastoma, the most common primary brain tumor in adults, provides new insights into the roles of several genes and defines core biological pathways altered in tumor development . The new Cancer Genome Atlas study, published in the September 4th advanced online edition of the journal Nature, [...]... Read more »
Roger McLendon, Allan Friedman, Darrell Bigner, Erwin G. Van Meir, Daniel J. Brat, Gena Mastrogianakis, Jeffrey J. Olson, Tom Mikkelsen, Norman Lehman, Ken Aldape.... (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. DOI: 10.1038/nature07385
It’s common knowledge that an example is more powerful than words. After all, aren’t parents routinely admonished for telling their children to do one thing while clearly breaking that same rule themselves? For parents and non-parents alike, saying one thing while doing something else greatly diminishes the influence of the words. Maybe that explains why [...]... Read more »
J. H. Tanne. (2008) Efforts to reduce US trainees' hours were ineffective, study says. BMJ, 337(aug05 2). DOI: 10.1136/bmj.a1140
A review of Efrosini Kalyva (2008). Comparison of Eating Attitudes between Adolescent Girls with and without Asperger Syndrome: Daughters’ and Mothers’ Reports Journal of Autism and Developmental Disorders DOI: 10.1007/s10803-008-0648-5The marked gender difference in the rate of autism spectrum diagnoses has resulted in a major gender disparity in research. That is, the overwhelming majority of studies on autism are conducted with boys, and studies examining mostly girls are very rare. The s........ Read more »
Efrosini Kalyva. (2008) Comparison of Eating Attitudes between Adolescent Girls with and without Asperger Syndrome: Daughters’ and Mothers’ Reports. Journal of Autism and Developmental Disorders. DOI: 10.1007/s10803-008-0648-5
Have you ever found yourself staring into a half-filled cup of water at a straw--wondering what kind of kooky laws light obeys that can result in this shattered view? Maybe not, but I bet Xiquan Cui and colleagues at...... Read more »
X. Cui, L. M. Lee, X. Heng, W. Zhong, P. W. Sternberg, D. Psaltis, & C. Yang. (2008) Lensless high-resolution on-chip optofluidic microscopes for Caenorhabditis elegans and cell imaging. Proceedings of the National Academy of Sciences, 105(31), 10670-10675. DOI: 10.1073/pnas.0804612105
Dr. Chad Orzel, a physics professor and blogger on ScienceBlogs.com, recently posted an interesting post, Dorky Poll: Non-Abelian Sciences, wherein Orzel pondered the difference between physical chemistry and chemical physics. Of course the standard reply: "If you publish in the...... Read more »
Lots of neat-o scientific discoveries were stumbled on by two or more people at about the same time. Sir Isaac Newton and Gottfried Wilhelm Leibniz both invented calculus. The first patent for an integrated circuit was given to Robert Noyce...... Read more »
Hesaam Esfandyarpour, Bo Zheng, R Pease, & Ronald Davis. (2008) Structural optimization for heat detection of DNA thermosequencing platform using finite element analysis. Biomicrofluidics, 2(2), 24102. DOI: 10.1063/1.2901138
High Dose Transdermal Buprenorphine for Pain - Alex DeLuca, Pain Relief Network, 2008-09-22
Journal article referenced:
Carlos Barutell, Alberto Camba, José-Ramón González-Escalada, Manuel Rodríguez (2008). High Dose Transdermal Buprenorphine for Moderate to Severe Pain in Spanish Pain Centres-A Retrospective Multicenter Safety and Efficacy Study Pain Practice, 8 (5), 355-361
TD Buprenorphine for Everything and Ever........ Read more »
Carlos Barutell, Alberto Camba, José-Ramón González-Escalada, & Manuel Rodríguez. (2008) High Dose Transdermal Buprenorphine for Moderate to Severe Pain in Spanish Pain Centres-A Retrospective Multicenter Safety and Efficacy Study. Pain Practice, 8(5), 355-361. DOI: 10.1111/j.1533-2500.2008.00205.x
What can online businesses learn from their web logs? According to Xueping Li of the Intelligent Information and Systems Laboratory, at the University of Tennessee, Knoxville, and colleagues, analyzing the information you can gather about the traffic to your website, whether…... Read more »
Xueping Li, Laigang Song, and Alberto Garcia-Diaz. (2008) Adaptive web presence and evolution through web log analysis . IInt. J. Electronic Customer Relationship Management , 2(3), 195-214.
"I always knew our Karen would do well"... these words, so typical of a proud mother, have taken on profound significance following a new study by Eirini Flouri and Denise Hawkes at the Institute of Education in London. Their research shows that a mother's expectations about about her daughter's future educational attainment may actually affect that child's future success at work, as well as her sense of control in life.Flouri and Hawkes used data collected from 1,520 men and 1,765 women as part........ Read more »
Eirini Flouri, & Denise Hawkes. (2008) Ambitious mothers - successful daughters: Mothers' early expectations for children's education and children's earnings and sense of control in adult life. British Journal of Educational Psychology, 78(3), 411-433. DOI: 10.1348/000709907X251280
Deep brain stimulation has shown promise in the treatment of treatment resistant depression(TRD) in some small series and case reports. The definition of TRD is still a matter of debate. There isn’t one clear classification scheme of TRD. TRD shouldn’t be mixed up with pseudoresistant depression . The recent research with deep brain stimulation showed [...]... Read more »
Jason S. Hauptman, Antonio A. F. DeSalles, Randall Espinoza, Mark Sedrak, & Warren Ishida. (2008) Potential surgical targets for deep brain stimulation in treatment-resistant depression. Neurosurgical FOCUS, 25(1). DOI: 10.3171/FOC/2008/25/7/E3
why do leaves turn red in the fall? It's all down to chemistry. Red pigments known as anthocyanins form in leaves from many plant and tree species at the same time as the green photosynthetic apparatus is dismantled by the plant. New research in PNAS this week explains abscission - the how and when of leaf fall.... Read more »
S. K. Cho, C. T. Larue, D. Chevalier, H. Wang, T.-L. Jinn, S. Zhang, & J. C. Walker. (2008) Regulation of floral organ abscission in Arabidopsis thaliana. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0805539105
The 1918 influenza pandemic that killed between 20 million and 100 million people world-wide was unusual in a lot of ways. One of the most extraordinary things about it was not just the high mortality rate, but the mortality pattern. Normally influenza kills the very old and the very young; but the 1918 [...]... Read more »
Laurel Yong-Hwa Lee, Do Lien Anh Ha, Cameron Simmons, Menno D. de Jong, Nguyen Van Vinh Chau, Reto Schumacher, Yan Chun Peng, Andrew J. McMichael, Jeremy J. Farrar, Geoffrey L. Smith.... (2008) Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. Journal of Clinical Investigation. DOI: 10.1172/JCI32460
Preparing my paper for Elisad on the strengths, weaknesses, opportunities and threats of Web 2.0, I’m grateful to the Blogging Section of SLA-IT and resource shelf respectively for highlighting articles on how to generate and limit User Generated Content.
As governmental organisations or NGOs, Alcohol and Other Drug (AOD) information providers have a real need to [...]... Read more »
Margaret Sica-Browm, & Jeffrey Beall. (2008) Library 2.0 and the problem of hate speech. Electronic Journal of Academic and Special Librarianship, 9(2). DOI/
Recent studies are making it increasingly apparent that cancer is really many different diseases – hundreds actually – in the sense that there are hundreds of distinct problems at a molecular level that can result in the symptoms of cancer in a large variety of tissue types. It is necessary to regard all these problems as distinct diseases, because different techniques will be necessary to deal effectively with each one. One of the things we are now understanding is that it is not si........ Read more »
Arkaitz Carracedo, Li Ma, Julie Teruya-Feldstein, Federico Rojo, Leonardo Salmena, Andrea Alimonti, Ainara Egia, Atsuo T. Sasaki, George Thomas, Sara C. Kozma.... (2008) Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. Journal of Clinical Investigation. DOI: 10.1172/JCI34739
tags: political views, politics, physiology, threat response, psychology, philosophyfight or flight, nature versus nurture
Most Americans have been actively engaged in the frustrating sport of arguing about politics, which often leads to the common refrain; "You just don't get it!" So this made me wonder why people who seem to have similar life experiences can end up with such dramatically different personal philosophies -- philosophies that ultimately affect their political views and voting be........ Read more »
D. R. Oxley, K. B. Smith, J. R. Alford, M. V. Hibbing, J. L. Miller, M. Scalora, P. K. Hatemi, & J. R. Hibbing. (2008) Political Attitudes Vary with Physiological Traits. Science, 321(5896), 1667-1670. DOI: 10.1126/science.1157627
My mom and step-dad live in a rather rough part of Miami and recently their house was robbed. It's actually an interesting story. A policeman happened to be driving by the house and noticed a car in the front yard. That's actually not very odd to see someone parked in their front yard in Miami, but whatever the policeman saw, it didn't look right. Well, his instinct turned out to be correct and he was able to thwart the robbery. The thief's took off running and search dogs and helicopters w........ Read more »
J FORGAS, & R EAST. (2008) On being happy and gullible: Mood effects on skepticism and the detection of deception☆. Journal of Experimental Social Psychology, 44(5), 1362-1367. DOI: 10.1016/j.jesp.2008.04.010
The decades that make up a typical human lifespan can seem like vast stretches of time to us. But to the forces of evolution, they are mere temporary blips. Common wisdom has it that evolution occurs over geological timescales - thousands and millions of years. As such, evolutionary biology takes a lot of criticism for being a 'descriptive science', being less open than other fields to that fundamental aspect of science - experimentation. Though there are exceptions, those who study evolution mu........ Read more »
J. B. Losos, T. W. Schoener, R. B. Langerhans, & D. A. Spiller. (2006) Rapid Temporal Reversal in Predator-Driven Natural Selection. Science, 314(5802), 1111-1111. DOI: 10.1126/science.1133584
Dermatologists are busily investigating that with which they are concerned - skin. The epidermis: a sensory tissue, by Boulais and Misery, is a 2008 paper providing an overview of information that has accumulated to date. Abstract:"The skin is an efficient barrier which protects our bodies from the external environment but it is also an important site for the perception of various stimuli. Sensory neurones of the peripheral nervous system send many primary afferent fibres to the skin. They pass ........ Read more »
Bayblab posted on this news story:
The body of an aristocrat who died nearly 90 years ago has been exhumed in the hope that it will help scientists combat a future flu pandemic.
Didn’t they already do roughly the same thing back in 2005?
Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus
Tumpey et al. Science [...]... Read more »
T. M. Tumpey, Christopher F. Basler, Patricia V. Aguilar, Hui Zeng, Alicia Solórzano, David E. Swayne, Nancy J. Cox, Jacqueline M. Katz, Jeffery K. Taubenberger, Peter Palese.... (2005) Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus. Science, 310(5745), 77-80. DOI: 10.1126/science.1119392
We tend to think of vicarious liability as a modern product of a society we believe is becoming more and more litigious. However, continuing my reading around case studies and their historical use, I’ve come across a portrait of how blame and fear of blame was heaped upon medical personnel delivering babies in 17th century [...]... Read more »
Lianne McTavish. (2006) Blame and vindication in the Early Modern birthing chamber. Medical History, 447-464. DOI/PMC1592634
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