I’ve become increasingly interested in the practice of paleoecology of late, trying to find and gather bits and pieces when I have time. This study from Molecular Ecology came to me, which, based on the probability that you can assign probabilities to cosmic events, I’m going to carefully and tentatively (and gentlemanly) attribute to Providence, or Wiley Interscience press releases.In the Yukon, there are several distinct caribou herds that inhabit and move within certain, definable regions........ Read more »
KUHN, T., MCFARLANE, K., GROVES, P., MOOERS, A., & SHAPIRO, B. (2010) Modern and ancient DNA reveal recent partial replacement of caribou in the southwest Yukon. Molecular Ecology. DOI: 10.1111/j.1365-294X.2010.04565.x
In the latest issue of J. Med. Chem., researchers from Roche in Basel have a nice analysis of intramolecular hydrogen bonds in druglike molecules. An internal hydrogen bond can intuitively confer an important property on a drug; it can make the drug more lipophilic by shielding the hydrogen bonding groups from solvent and render it more lipophilic. Thus, intramolecular h-bonding has emerged as a useful strategy in improving membrane permeability.The authors look at both the CSD and the PDB and d........ Read more »
Kuhn, B., Mohr, P., & Stahl, M. (2010) Intramolecular Hydrogen Bonding in Medicinal Chemistry. Journal of Medicinal Chemistry, 2147483647. DOI: 10.1021/jm100087s
Scientists have provided a rather grim prognosis for global health: the recent increase in nutrient enrichment due to human activities, such as nitrogen pollution through fossil fuel combustion, is likely contributing to several varieties of infectious diseases in humans and wildlife.
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Johnson, P., Townsend, A., Cleveland, C., Glibert, P., Howarth, R., McKenzie, V., Rejmankova, E., & Ward, M. (2010) Linking environmental nutrient enrichment and disease emergence in humans and wildlife. Ecological Applications, 20(1), 16-29. DOI: 10.1890/08-0633.1
by Nestor Lopez-Duran PhD in Child-Psych
I spent most of my Sunday afternoon reviewing and editing reports of child neuropsychological evaluations. Most of them were for children who came to our clinic for a comprehensive ADHD diagnostic evaluation. At the end of these reports we always include a large number of individualized recommendations for home and school accommodations and interventions. Within [...]... Read more »
Epstein, J., Langberg, J., Lichtenstein, P., Altaye, M., Brinkman, W., House, K., & Stark, L. (2010) Attention-Deficit/Hyperactivity Disorder Outcomes for Children Treated in Community-Based Pediatric Settings. Archives of Pediatrics and Adolescent Medicine, 164(2), 160-165. DOI: 10.1001/archpediatrics.2009.263
The introduction of so-called Flagged Revisions on the infamous online information repository, Wikipedia, do not go far enough to allow the site to mature into an accurate and wholly verifiable Internet resource. Instead, the adoption of more traditional values is the only way forward, argue Australian information experts.
Wikipedia is a user-produced online encyclopedia and, since [...]Post from: David Bradley's Sciencetext Tech TalkHow to fix Wikipedia
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Lichtenstein, S., & Parker, C. (2009) Wikipedia model for collective intelligence: a review of information quality. International Journal of Knowledge and Learning, 5(3/4), 254. DOI: 10.1504/IJKL.2009.031199
A new study wades into the contentious debate about whether land protection negatively affects the housing supply for local communities.
Pro-development advocates have argued that land conservation removes properties from the pool of potential residential housing and therefore drives up home prices. Some studies have found empirical support for this argument.
However new research from scientists at Stanford University and the Nature Conservancy finds that conservation efforts in the suburb........ Read more »
Denning, C., Mcdonald, R., & Christensen, J. (2010) Did land protection in Silicon Valley reduce the housing stock?. Biological Conservation. DOI: 10.1016/j.biocon.2010.01.025
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Godfray, H., Beddington, J., Crute, I., Haddad, L., Lawrence, D., Muir, J., Pretty, J., Robinson, S., Thomas, S., & Toulmin, C. (2010) Food Security: The Challenge of Feeding 9 Billion People. Science, 327(5967), 812-818. DOI: 10.1126/science.1185383
Over the past few years, deep brain stimulation (DBS) has emerged as a promising treatment for severe psychiatric disorders that haven't responded to conventional approaches. A new paper from the University of Florida reports on a trial of DBS in obsessive-compulsive disorder (OCD), and unlike most DBS studies, it was placebo-controlled: Deep Brain Stimulation for Intractable Obsessive Compulsive Disorder.Six patients were implanted with electrodes in the "ventral capsule/ventral striatum" (VC/V........ Read more »
Goodman, W., Foote, K., Greenberg, B., Ricciuti, N., Bauer, R., Ward, H., Shapira, N., Wu, S., Hill, C., & Rasmussen, S. (2010) Deep Brain Stimulation for Intractable Obsessive Compulsive Disorder: Pilot Study Using a Blinded, Staggered-Onset Design. Biological Psychiatry, 67(6), 535-542. DOI: 10.1016/j.biopsych.2009.11.028
Most of us don’t think much about yellow fever nowadays. There are still a couple hundred thousand cases, and some 30,000 deaths, each year, but almost none are in the first world. Out of sight, out of mind.
But this indifference is new. Until the beginning of the 20th century, yellow fever ran rampant, and [...]... Read more »
C. Finlay. (1881) El mosquito hipoteticamente considerado como agente de trasmislon de la flebre amarllla. An. de la Real Academia de ciencias med. de la Habana, 147-169. info:/
What should we do when perfectly good habitat exists but certain species of wildlife decide to avoid it anyway? Researchers from the University of Oklahoma grapple with this potential mismatch between wildlife perception and habitat quality - a phenomenon they call the "Perceptual Trap."... Read more »
A pharmacist in the Gibson Desert wanted to take part in the recent mass homeopathic overdose protest organized by the 10:23 movement. Unbeknown to him, the cleaning lady had been around and accidentally mixed up the homeopathic pills with slow release verapamil. After gulping down a couple of handfuls of pills, the pharmacist's heightened gustatory awareness alerted him to the presence of verapamil in the tablets. Although he remains asymptomatic, he has a feeling that something bad might hap........ Read more »
Nickson CP, & Little M. (2009) Early use of high-dose insulin euglycaemic therapy for verapamil toxicity. The Medical journal of Australia, 191(6), 350-2. PMID: 19769561
Astronomers have long known that there is a rather close relationship between the intrinsic luminosity of a spiral galaxy and the rotational velocity of stars (around the galactic center) in the outer portions of the galaxy. This relationship even has a name: the Tully-Fisher relation.It has also been known that small, nearby dwarf galaxies, which are irregular in shape, are not nearly as bright as they "should" be, according to the Tully-Fisher relation, given the measured average velocities of........ Read more »
Can confidence ever be a bad thing? What if it happens to be confidence in your own self-doubt? In a pair of mind-bending experiments Aaron Wichman and colleagues show that doubt layered on doubt doesn't lead to more doubt but rather to increased confidence, as the initial self-doubt is undermined. The researchers say their findings have clinical implications - for instance, by turning a belief that one is definitely going to fail into a belief that one might fail, a therapist could help inspire........ Read more »
A recent study in the Annals of Internal Medicine found that a simple tailored treatment for high cholesterol provides more benefit per person treated and prevented significantly more coronary artery disease morbidity and death than the currently recommended treat-to-target approaches.... Read more »
Hayward RA, Krumholz HM, Zulman DM, Timbie JW, & Vijan S. (2010) Optimizing statin treatment for primary prevention of coronary artery disease. Annals of internal medicine, 152(2), 69-77. PMID: 20083825
by Moselio Schaechter in Small Things Considered
by Elio Binary fission is a most impressive invention. In one fell swoop, it ensures that progeny cells are born alike and endowed with the same potential for growth and survival. Simple as it sounds, it must have taken considerable evolutionary contortions to make it function so well throughout the living world. But there are cells that have adopted an...... Read more »
Liu, B., Larsson, L., Caballero, A., Hao, X., Öling, D., Grantham, J., & Nyström, T. (2010) The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates. Cell, 140(2), 257-267. DOI: 10.1016/j.cell.2009.12.031
One of the causes of age-related degeneration and disease is the buildup of amyloid clumps and other forms of aggregated metabolic byproducts. A brief outline: As we get older, many different types of errant and unwanted proteins, the chemical byproducts of metabolism, build up and accumulate between our cells. Collectively these are known as forms of amyloid, a term that might be familiar to you in connection with Alzheimer's disease, but there are many other types of amyloid beyond that implic........ Read more »
Murray AN, Solomon JP, Balch WE, & Kelly JW. (2010) Discovery and characterization of a mammalian amyloid disaggregation activity. Protein science : a publication of the Protein Society. PMID: 20162625
by Cody Cobb in Biofortified
As a molecular biologist, most of my work is done on a bench at or below room temperature. I can count on one hand the number of times I’ve been to a research field because I have more than two fingers. I’ve never taken a course in ecology, and I’ve rarely dealt with full, intact [...]... Read more »
Snow, A., Pilson, D., Rieseberg, L., Paulsen, M., Pleskac, N., Reagon, M., Wolf, D., & Selbo, S. (2003) A Bt TRANSGENE REDUCES HERBIVORY AND ENHANCES FECUNDITY IN WILD SUNFLOWERS. Ecological Applications, 13(2), 279-286. DOI: 10.1890/1051-0761(2003)013[0279:ABTRHA]2.0.CO;2
Babyak (2000) examined the use of physical activity as a treatment for depression. Participants classified as clinically depressed were given, aerobic exercise, drugs or both as treatment. The exercise only group recovered as well as the other groups but had a lower relapse rate, perhaps caused by the participants feeling that they had a more active role in their treatment. The exercise group also a side effect of the participants getting fitter! There are many other studies associating par........ Read more »
Babyak M, Blumenthal JA, Herman S, Khatri P, Doraiswamy M, Moore K, Craighead WE, Baldewicz TT, & Krishnan KR. (2000) Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosomatic medicine, 62(5), 633-8. PMID: 11020092
Researchers in Delhi at the National Institute of Plant Genome Research have developed a tomato that has a shelf-life of 45 days. A. Datta and S. Chakraborty with co-workers report in the paper published in the Proceedings of the National Academy of Sciences that they identified the ripening-specifics enzymes and silenced those genes through RNA interference.
India [...]... Read more »
Meli, V., Ghosh, S., Prabha, T., Chakraborty, N., Chakraborty, S., & Datta, A. (2010) Enhancement of fruit shelf life by suppressing N-glycan processing enzymes. Proceedings of the National Academy of Sciences, 107(6), 2413-2418. DOI: 10.1073/pnas.0909329107
The influence of the motor system on speech perception has been getting tons of high profile attention lately and "sensorimotor theories" of speech perception are gaining popularity. For an interesting example of the such a theory, check out Jean-Luc Schwartz et al.'s, The Perception-for-Action-Control Theory (PACT): A perceptuo-motor theory of speech perception. It is all well-and-good to understand the contribution of motor information to speech perception, but let's not forget that there is........ Read more »
Shahin, A., Bishop, C., & Miller, L. (2009) Neural mechanisms for illusory filling-in of degraded speech. NeuroImage, 44(3), 1133-1143. DOI: 10.1016/j.neuroimage.2008.09.045
Myers EB, & Blumstein SE. (2008) The neural bases of the lexical effect: an fMRI investigation. Cerebral cortex (New York, N.Y. : 1991), 18(2), 278-88. PMID: 17504782
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