Discusses changes to the Triassic Period in the newly published geological timescale.... Read more »
The working of Stefan’s diathermometer to measure the thermal conductivity was explained earlier. Here we recount how the diathermometer helped also in the prediction of the T to the fourth power law of electromagnetic radiation purely by experimental means. It was an instance of scientific advancement, where the experimental outcome preceded the theoretical support. We [...]... Read more »
Crepeau, J. (2007) Josef Stefan: His life and legacy in the thermal sciences. Experimental Thermal and Fluid Science, 31(7), 795-803. DOI: 10.1016/j.expthermflusci.2006.08.005
In this week's issue of PLoS Biology, an essay describes the perfect means for controlling malaria-carrying mosquitoes: an "evolution-proof insecticide." By taking advantage of the life history traits of both mosquitoes and the malaria parasite, Read et al. argue it should be possible to create an insecticide that will cut malaria transmission without selecting for resistance in the mosquitoes.
Malaria remains a major public health problem in much of the world - according the World Health Organ........ Read more »
McMeniman, C., Lane, R., Cass, B., Fong, A., Sidhu, M., Wang, Y., & O'Neill, S. (2009) Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti. Science, 323(5910), 141-144. DOI: 10.1126/science.1165326
Read, A., Lynch, P., & Thomas, M. (2009) How to make evolution-proof insecticides for malaria control. PLoS Biology, 7(4). DOI: 10.1371/journal.pbio.1000058
Ah, the lovely Journal of Medical Hypotheses. I went to it last week for a post on ear wax, and what should be the article right before it, but a post on erectile dysfunction. I think this journal's impact factor is underrated. It certainly makes an impact on ME.
Anyway, as I'm sure you are all aware from the multitude of commercials out there for Viagra, Levitra, Cialis, and other such drugs that are making companies a LOT of money, erectile dysfunction (ED) is a bit of a problem in modern ........ Read more »
Ahmadian, S., & Fakhree, M. (2009) Earwax (cerumen) might be formulated into a safe and biodegradable insect repellent. Medical Hypotheses, 72(3), 370-371. DOI: 10.1016/j.mehy.2008.09.036
As the faux conservative pundit Stephen Colbert warned President Bush, reality has a bias to the left. And interestingly enough, so does all life on Earth. We’ve know that all amino acids, the essential components for any terrestrial organism, have left-handed chiralities. Or to translate from science-speak, their molecules wind to the left. This is [...]... Read more »
Glavin, D., & Dworkin, J. (2009) Enrichment of the amino acid L-isovaline by aqueous alteration on CI and CM meteorite parent bodies. Proceedings of the National Academy of Sciences, 106(14), 5487-5492. DOI: 10.1073/pnas.0811618106
Religion and mental health seems to be a double-edged sword. Religion features in a lot of psychotic delusions, but there's also a lot of evidence linking religious belief to better mental health. There's some new research which suggests that part of the problem in teasing out the relationships is that it's not belief itself, but rather the type of god that you believe in, that matters.The data came from a 2004 US survey on religion and health, which included measures of what people thought abou........ Read more »
Flannelly, K., Galek, K., Ellison, C., & Koenig, H. (2009) Beliefs about God, Psychiatric Symptoms, and Evolutionary Psychiatry. Journal of Religion and Health. DOI: 10.1007/s10943-009-9244-z
Flannelly, K., & Galek, K. (2009) Religion, Evolution, and Mental Health: Attachment Theory and ETAS Theory. Journal of Religion and Health. DOI: 10.1007/s10943-009-9247-9
Background: TH17 discussed previously here; previous brief run-down of T-cell development here.TH17 cells are an inflammatory T-cell subtype implicated in acute adaptive immune response as well as chronic autoimmune diseases. We have known for a while now how to create TH17 cells in a dish: just as TGFb and IL-6 (a general T-cell proliferation cytokine such as IL-2 wouldn't hurt either). However, we haven't been very clear on how exactly those kind of conditions would arise in vivo. TGFb is a........ Read more »
Torchinsky, M., Garaude, J., Martin, A., & Blander, J. (2009) Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation. Nature, 458(7234), 78-82. DOI: 10.1038/nature07781
by Drew Rosielle MD in Pallimed: a Hospice & Palliative Medicine Blog
Lancet has the results of a multi-national randomized controlled trial of balloon kyphoplasty for vertebral compression fractures. This was an industry-funded trial of ~300 patients with 1-3 acute or subacute (less than 3 months old - mean was 6 weeks old), painful (4/10 or greater) VCFs who were randomized to KP or medical management/routine supportive care (meds, braces, therapy, etc.). They followed patients for 12 months, although the primary outcome was changes in the SF-36 quality of lif........ Read more »
Wardlaw, D., Cummings, S., Van Meirhaeghe, J., Bastian, L., Tillman, J., Ranstam, J., Eastell, R., Shabe, P., Talmadge, K., & Boonen, S. (2009) Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. The Lancet, 373(9668), 1016-1024. DOI: 10.1016/S0140-6736(09)60010-6
It seems obvious that the value of some potentially rewarding endeavor should reflect not just the size of the reward but also the amount of effort involved in realizing it. But how do we make that decision? In business, this can be an external computation: some analyst will sit down in front of Excel and [...]... Read more »
Croxson, P., Walton, M., O'Reilly, J., Behrens, T., & Rushworth, M. (2009) Effort-Based Cost-Benefit Valuation and the Human Brain. Journal of Neuroscience, 29(14), 4531-4541. DOI: 10.1523/JNEUROSCI.4515-08.2009
I am now ready to post-doc. I am also now ready to post-dock, that is, engage in activities beyond docking. Sorry, I could not resist cracking that terrible joke. It's been a long journey and I have enjoyed every most moments of it. Thanks to everyone in the chemistry blogworld who regaled, informed, provoked and entertained on this blog. I am now ready to move on to the freakingly chilly Northeast. Location not disclosed for now, but maybe later.Speaking of docking, here is a nice paper from th........ Read more »
Chen, Y., & Shoichet, B. (2009) Molecular docking and ligand specificity in fragment-based inhibitor discovery. Nature Chemical Biology. DOI: 10.1038/nchembio.155
A Korean team report the generation of a RFP-transgenic beagle. Dogs exhibits 224 genetic diseases similar to those found in humans making them one of the closest known models for various human hereditary diseases. However, experimentation with animal -which should be at the service of the whole mankind - raises strong and acute ethical challenges, particularly if the experimental model is a pet. Although still prototypical, the concept of "reporter animal" arguments toward a new use of a........ Read more »
Hong, S., Kim, M., Jang, G., Oh, H., Park, J., Kang, J., Koo, O., Kim, T., Kwon, M., Koo, B.... (2009) Generation of red fluorescent protein transgenic dogs. genesis. DOI: 10.1002/dvg.20504
Hierarchical clustering of breast carcinomas1
Something that’s puzzled me for years is why the same kinds of tumors tend to have the same kinds of immune evasion mechanisms. And I’m not going to give an answer, just trying to share the confusion a little.
What I mean is this:
It has been demonstrated that human tumors of distinct [...]... Read more »
Seliger, B. (2008) Molecular mechanisms of MHC class I abnormalities and APM components in human tumors. Cancer Immunology, Immunotherapy, 57(11), 1719-1726. DOI: 10.1007/s00262-008-0515-4
Photo by Mike Baird.As I have discussed before, I believe that incorporating physical activity into daily life is one of the easiest ways for people to increase their physical activity levels, and improve their metabolic health. Although structured physical activity (e.g. working out in the gym) is great for some people, it is definitely not for everyone, myself included. What's more, recent evidence suggests that some individuals may compensate for structured physical activity by actually red........ Read more »
Vanhecke, T., Franklin, B., Miller, W., deJong, A., Coleman, C., & McCullough, P. (2009) Cardiorespiratory Fitness and Sedentary Lifestyle in the Morbidly Obese. Clinical Cardiology, 32(3), 121-124. DOI: 10.1002/clc.20458
by Nestor L. Lopez-Duran PhD in Child-Psych
Is having multiple childcare arrangements during early childhood associated with increased behavioral problems in toddlers?A review of Morrissey, T. (2009). Multiple Child-Care Arrangements and Young Children’s Behavioral Outcomes Child Development, 80 (1), 59-76 DOI: 10.1111/j.1467-8624.2008.01246.xIn the last issue of the journal Child Development, Dr. Taryn Morrissey conducts a comprehensive
Read the full post at www.child-psych.org
Read the full post at www.child-psych.org
Read the ful........ Read more »
Morrissey, T. (2009) Multiple Child-Care Arrangements and Young Children’s Behavioral Outcomes. Child Development, 80(1), 59-76. DOI: 10.1111/j.1467-8624.2008.01246.x
Should your boss be allowed to read your text messages, your emails, your tweets? The answer to that question is not, legally speaking, quite so clear cut as you might hope. After all, if you’re texting (SMS) or tweeting on company time, using a company computer or cell phone, then you might be breaking your [...]Post from: David Bradley's Sciencetext Tips and Tricks
Private Texts Not So Confidential... Read more »
Gregory C. Mosier. (2009) Text messages: privacy in employee communications in the USA. Int. J. Private Law, 2(3), 260-266.
One interesting question this study raises is an evolutionary one. Could we have evolved antibodies that bind two completely different epitopes? When we use antibodies in the lab, we tend to screen against those that are promiscuous: bind more than one epitope. But maybe such antibodies do exist?... Read more »
Bostrom, J., Yu, S., Kan, D., Appleton, B., Lee, C., Billeci, K., Man, W., Peale, F., Ross, S., Wiesmann, C.... (2009) Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site. Science, 323(5921), 1610-1614. DOI: 10.1126/science.1165480
Chocolate milk after intensive prolonged exercise helps recovery much better than a carbohydrate replacement drink or a fluid replacement drink. After my 10 kilometer run on Sunday I’ll have some chocolate milk.
This was tested in a study in which during recovery from prolonged exercise (cycling) the participants ingested chocolate milk, carbohydrate replacement drink or a [...]... Read more »
Thomas, K., Morris, P., & Stevenson, E. (2009) Improved endurance capacity following chocolate milk consumption compared with 2 commercially available sport drinks. Applied Physiology, Nutrition, and Metabolism, 34(1), 78-82. DOI: 10.1139/H08-137
Now I’m a big fan of alternative biochemistry theories in the search for extraterrestrial life. It seems logical to think that given the size of the universe and the number of possible environments out there, life might have found more than one way to organise itself. However, thanks to some clever thermodynamics, it looks quite likely that at least some alien life out there might not be so “alien” after all…... Read more »
Paul G. Higgs, Ralph E. Pudritz. (2009) A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code. Astrobiology (accepted). DOI: 0904.0402v1
For the last 50 years or more, ballet dancers performing The Sleeping Beauty at the Royal Opera House in Covent Garden have been raising their legs progressively higher. This trend, identified by Elena Daprati and colleagues, provides a wonderful example of how aesthetic form evolves over time, reflecting a mix of changing audience taste and artistic creativity.Deprati's team collected photographic and video archive material from performances of a single piece of choreography - the "Rose Adagio"........ Read more »
Daprati, E., Iosa, M., & Haggard, P. (2009) A Dance to the Music of Time: Aesthetically-Relevant Changes in Body Posture in Performing Art. PLoS ONE, 4(3). DOI: 10.1371/journal.pone.0005023
Having somewhat recently realized that I don't want to have the awesomely statuesque physique of a stick figure for the rest of my life, I began working out (before and after picture below). I still have no idea how to use most of the equipment in the gym and I'm not going to ask Pikkuveli (="little brother") how to use it just because he has ~130kg of muscle to my paltry ~60kg (we're also the same height: ~2.07m). But I am willing to ask where muscles come from.So I hit up Current Opinion in ........ Read more »
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