Post List

  • November 14, 2009
  • 12:25 PM

Prions activate neuronal cholesterogenic gene expression

by Brian Appleby in CJD Blogger

Herman Schatzl, who recently received an endowed chair at the University of Wyoming, and colleagues published an article in The Journal of Biological Chemistry early this year on the effects of prion proteins on the expression of cholesterol-associated genes.  The experiment was an in vitro study using cultured neurons that were infected with the 22L prion strain.  They examined gene expression of genes involved in the cholesterol pathway in neurons and supportive cells. The authors........ Read more »

Bach C, Gilch S, Rost R, Greenwood AD, Horsch M, Hajj GN, Brodesser S, Facius A, Schädler S, Sandhoff K.... (2009) Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells. The Journal of biological chemistry, 284(45), 31260-9. PMID: 19748890  

  • November 14, 2009
  • 11:21 AM

More on Medical Marijuana

by Neuroskeptic in Neuroskeptic

Previously I wrote about a small study finding that smoked marijuana helps with HIV-related pain. In the last month, two more clinical trials of medical marijuana - or rather, marijuana-based drugs - for pain have come out.First, the good news. Johnson et al tested a mouth spray containing the two major psychoactive chemicals in marijuana, THC and CBD. Their patients were all suffering from terminal cancer, which believe it or not, is quite painful. Almost all of the subjects were already taking........ Read more »

  • November 14, 2009
  • 11:02 AM

Cancer – To Screen or Not to Screen?

by Shaheen Lakhan in Brain Blogger

I once treated a patient who was in her 90s. She was less than 5 feet tall and had never weighed more than 90 pounds. But, she was tough as nails and had lived a great life. I came to advocate for her when the internist at the skilled nursing facility in which she lived [...]... Read more »

Esserman, L., Shieh, Y., & Thompson, I. (2009) Rethinking Screening for Breast Cancer and Prostate Cancer. JAMA: The Journal of the American Medical Association, 302(15), 1685-1692. DOI: 10.1001/jama.2009.1498  

Greenwald P. (2007) A favorable view: progress in cancer prevention and screening. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 3-17. PMID: 17302181  

  • November 14, 2009
  • 10:23 AM

Dead Zones, Conservation and Commercial Fishing

by Johnny in Ecographica

...project will undoubtedly have implications for both the science of ecology and in that of conservation. Shrimping is a major industry in the United States, and as such the participating fishermen and other commercial industries hold considerable economic and political clout. I’m reminded of the warnings from biologists that were unheeded and initially overthrown by rule-makers during the collapse of the Northern Cod Fishery…
... Read more »

  • November 13, 2009
  • 09:50 PM

Methods Blogging: The Prostate Cancer Prevention Trial

by Ryan in Evidence-Based Public Health

It's somewhat defeating to acknowledge, but a large part of the strength (and beauty) of this study lies in its simplicity. Placebo-controlled, double-blinded, randomized; these are the things biostatisticians dream of. Luckily, I'm not one; but I can still appreciate it.... Read more »

Gerald L. Andriole, M.D., E. David Crawford, M.D., Robert L. Grubb, III, M.D., Saundra S. Buys, M.D., David Chia, Ph.D., Timothy R. Church, Ph.D., Mona N. Fouad, M.D., Edward P. Gelmann, M.D., Paul A. Kvale, M.D., Douglas J. Reding, M.D., Joel L. Weissfel. (2009) Mortality Results from a Randomized Prostate-Cancer Screening Trial. New England Journal of Medicine, 360(17), 1797-1797. DOI: 10.1056/NEJMx090012  

  • November 13, 2009
  • 07:04 PM

Rare Diagnostic Case of the Month: Notalgia Paresthetica

by Dr. Wayne Button in Sport Injuries and Wellness

Learn about this rare cause of interscapular pain.... Read more »

  • November 13, 2009
  • 04:37 PM

Virtual Counterinsurgency

by Randy Borum in Science of Global Security & Armed Conflict

What seems to give the West the most trouble in counterinsurgency (COIN) is not killing bad guys, but preventing new flocks of bad guys from continuously emerging. There is often talk of “draining the swamps” and “stemming the tide,” but violent extremism continues to spread – though in some circles more easily than others. The US and Western allies seem to understand – at some level – that the informational element of the battlespace reaches beyond traditional propaganda. They........ Read more »

  • November 13, 2009
  • 04:27 PM

Looking Back

by teofilo in Follow the Energy

The study of energy production and consumption is based heavily on models and projections from those models.  There are a lot of models out there, and they differ from each other to varying degrees based on the assumptions they make.  One criticism people often make of these models is that there is too seldom any [...]... Read more »

  • November 13, 2009
  • 01:59 PM

Mumps redux

by PalMD in White Coat Underground

The resurgence of vaccine-preventable diseases is a fascinating, if unwanted, phenomenon. Pertussis, measles, and now mumps are cropping up after long periods of quiescence. Mumps has been generally very well-controlled since the adoption of wide-spread vaccination, with no nation-wide outbreaks, but there have been a number of regional outbreaks, most notably in 2006 and now again in 2009. Since the widespread use of two-dose vaccines, mumps cases in the US have dropped by more than 99%.

In........ Read more »

  • November 13, 2009
  • 01:09 PM

Settling Scores

by Journal Watch Online in Journal Watch Online

U.S. shows many more record high temperatures than lows

... Read more »

Meehl, G., Tebaldi, C., Walton, G., Easterling, D., & McDaniel, L. (2009) The relative increase of record high maximum temperatures compared to record low minimum temperatures in the U.S. Geophysical Research Letters. info:/10.1029/2009GL040736

  • November 13, 2009
  • 11:53 AM

New research – stapled proteins

by Avril in Understanding Cancer

There are several news reports out today about a new way of turning off cancer causing proteins. These reports are based on a study in the journal Nature called “Direct Inhibition of the NOTCH transcription factor complex“, you will need to pay to read the article in it’s full technical detail, but there are several [...]... Read more »

Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, & Bradner JE. (2009) Direct inhibition of the NOTCH transcription factor complex. Nature, 462(7270), 182-8. PMID: 19907488  

  • November 13, 2009
  • 11:10 AM

Dyslexia and the Cocktail Party effect

by Mo in Neurophilosophy

IMAGINE sitting in a noisy restaurant, across the table from a friend, and having a conversation with them as you eat your meal. To communicate effectively in this situation, you have to extract the relevant information from the noise in the background, as well as from other voices. To do so, your brain somehow "tags" the predictable, repeating elements of the target signal, such as the pitch of your friend's voice, and segregates them from other signals in the surroundings, which fluctuate rand........ Read more »

  • November 13, 2009
  • 10:25 AM

Wetland Plant of the Week #32

by Johnny in Ecographica

Asterales, the order to which the Asteraceae family belongs, has origins in the Cretaceous period about 100 million years ago and probably experienced diversification during the Oligocene and Miocene. In regards to their evolutionary past, recent research by Tom Viaene (et al) examined the variability of stamen and petal morphologies within the basal asterid families. Through comparisons of the genes that coded for these floral structures, he determined that the early members of the asterid grou........ Read more »

Viaene, T., Vekemans, D., Irish, V., Geeraerts, A., Huysmans, S., Janssens, S., Smets, E., & Geuten, K. (2009) Pistillata--Duplications as a Mode for Floral Diversification in (Basal) Asterids. Molecular Biology and Evolution, 26(11), 2627-2645. DOI: 10.1093/molbev/msp181  

  • November 13, 2009
  • 09:00 AM

Eating speed and calorie control: Weight of the evidence

by Colby in

Recently, a paper by Kokkinos et al. (1) was published on an experiment finding different postprandial Peptide YY and Glucagon-Like Peptide-1 concentration responses with varying eating speed.  This immediately prompted such media headlines as: “Eating Slowly May Help Weight Control,” “Cut Calories by Eating Slowly,” “Eating Slowly Can Help with Weight Loss,” and “Eating Quickly [...]... Read more »

Kokkinos A, le Roux CW, Alexiadou K, Tentolouris N, Vincent RP, Kyriaki D, Perrea D, Ghatei MA, Bloom SR, & Katsilambros N. (2009) Eating Slowly Increases the Postprandial Response of the Anorexigenic Gut Hormones, Peptide YY and Glucagon-Like Peptide-1. The Journal of clinical endocrinology and metabolism. PMID: 19875483  

Gaul, D., Craighead, E., & Mahoney, M. (1975) Relationship between eating rates and obesity. Journal of Consulting and Clinical Psychology, 43(2), 123-125. DOI: 10.1037/h0076522  

Marston AR, London P, Cohen N, & Cooper LM. (1977) In vivo observation of the eating behavior of obese and nonobese subjects. Journal of consulting and clinical psychology, 45(2), 335-6. PMID: 850018  

Andrade AM, Greene GW, & Melanson KJ. (2008) Eating slowly led to decreases in energy intake within meals in healthy women. Journal of the American Dietetic Association, 108(7), 1186-91. PMID: 18589027  

  • November 13, 2009
  • 08:00 AM

Recovery of albatross may depend on removing paint

by Rob Goldstein in Conservation Maven

Scientists estimate that lead paint chips from deteriorating buildings on the Midway Atoll are killing thousands of Laysan albatross juveniles every year. The poor chicks eat the paint chips, which cause toxic effects such as droopwing.

The research team led by Myra Finkelstein developed a demographic model to calculate the benefit that removing the lead paint would have for conserving the species. Their findings published in the journal Animal Conservation run counter to conventional thinkin........ Read more »

  • November 13, 2009
  • 08:00 AM

Genetically engineered heavy metal fans

by sciencebase in Sciencebase Science Blog

The wastewater released from industry often contains high levels of toxic heavy metals, which can kill organisms, damage ecosystems, and accumulate in the foodchain. Electroplating, lead smelting, mining, and countless other processes produce enormous volumes of such wastewater.
In a perfect world, remediation would be powered by a renewable energy supply, there would be no solid [...]Genetically engineered heavy metal fans is a post from: Sciencebase Science Blog
... Read more »

Bhupinder Dhir. (2010) Use of aquatic plants in removing heavy metals from wastewater. Int. J. Environmental Engineering, 2(1/2/3), 185-201. info:/

  • November 13, 2009
  • 07:00 AM

Mobile malware epidemic on the way

by David Bradley in Sciencetext

A mobile malware epidemic could render phone networks useless within two to three years, if public awareness of the issue and network security experts don’t take control out of the hands of hackers.

If you’re intelligent enough to be reading the Sciencetext blog, then it’s unlikely that you’re going to be taken in by an email [...]Post from: David Bradley's Sciencetext Tech TalkMobile malware epidemic on the way
... Read more »

Juil C. Martin, Legand L. Burge III, Joseph I. Gill, Alicia N. Washington, & Marcus Alfred. (2010) Modelling the spread of mobile malware. Int. J. Computer Aided Engineering and Technology, 2(1), 3-14. info:/

  • November 13, 2009
  • 06:29 AM

Confused About Abdominal Bloating? - No More!

by Michael Ash in Nutri-Link Ltd - Clinical Education

Michael Ash BSc(Hons).DO. ND. FDipION reviews the current understanding behind bloating and distension.

The unpleasant symptoms of bloating and abdominal distension are common and bothersome, affecting up to 96% of patients with functional gastrointestinal disorders (such as IBS) and an estimated 30% of the general population. Clear pathophysiologic explanations have been lacking and available treatment options can appear contradictory and ineffective. Treatments will be explored in a follow ........ Read more »

Houghton LA, & Whorwell PJ. (2005) Towards a better understanding of abdominal bloating and distension in functional gastrointestinal disorders. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 17(4), 500-11. PMID: 16078938  

Cremon C, Gargano L, Morselli-Labate AM, Santini D, Cogliandro RF, De Giorgio R, Stanghellini V, Corinaldesi R, & Barbara G. (2009) Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms. The American journal of gastroenterology, 104(2), 392-400. PMID: 19174797  

  • November 13, 2009
  • 06:00 AM

At Your Service….

by Elements Team in Elements

Part I: The Role of Animals in Public Health

By: Rosemary Stephen, Elements: Environmental Health Intelligence

Pets are very important in the lives of people around the world. Many of us feel we cannot live without our pets; I know I feel that way. I still remember the first cat we ever owned. We got him from [...]... Read more »

Rosemary Stephen. (2009) At Your Service.. Elements: Environmental Health Intelligence. info:/

  • November 13, 2009
  • 06:00 AM

At Your Service…. Part I

by Elements Team in Elements

Part I: The Role of Animals in Public Health

By: Rosemary Stephen, Elements: Environmental Health Intelligence

Pets are very important in the lives of people around the world. Many of us feel we cannot live without our pets; I know I feel that way. I still remember the first cat we ever owned. We got him from [...]... Read more »

Rosemary Stephen. (2009) At Your Service.. Elements: Environmental Health Intelligence. info:/

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