Ebola virus has impressed me as creepy ever since I read "... Read more »
Jonathan S. Towner, Tara K. Sealy, Marina L. Khristova, César G. Albariño, Sean Conlan, Serena A. Reeder, Phenix-Lan Quan, W. Ian Lipkin, Robert Downing, Jordan W. Tappero.... (2008) Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda. PLoS Pathogens, 4(11). DOI: 10.1371/journal.ppat.1000212
J. S. Towner. (2006) Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in Angola. Journal of Virology, 80(13), 6497-6516. DOI: 10.1128/JVI.00069-06
Edouard Machery at the Experiments in Philosophy blog writes about a study he conducted with Zalla that found that people with Aspergers syndrome were deficient when it came to identifying purely instrumental desires and the actions resulting from them as intentional actions. but to understand all that we have to understand the concept of purely instrumental desire. This is best done with the free-cup and extra-dollar cases that Machery has constructed to illustrat........ Read more »
EDOUARD MACHERY. (2008) The Folk Concept of Intentional Action: Philosophical and Experimental Issues. Mind , 23(2), 165-189. DOI: 10.1111/j.1468-0017.2007.00336.x
Pacing is one of those words: almost every person who has been through a pain management programme of any sort will roll their eyes and groan ‘pacing’ when asked about one of their least favourite strategies.
I have long disliked the word because of the mixed ways in which therapists (and patients) interpret what it actually [...]... Read more »
J GILL, & C BROWN. (2008) A structured review of the evidence for pacing as a chronic pain intervention. European Journal of Pain. DOI: 10.1016/j.ejpain.2008.03.011
Think of a copper tea kettle (I'm cold, tea is warm...). When you think about it, where is it? It's in a kitchen, right? Possibly on a stove. It's definitely in a context where you would expect it to be. Now take that tea kettle, and put it in your mind somewhere like...a desert. Surrounded by sand and sky. Now you're not thinking of tea anymore. But doesn't the copper gleam a little better? It might be out of context, but the tea kettle looks really...pretty!
Ok, maybe you don't fol........ Read more »
Ulrich Kirk. (2008) The Neural Basis of Object-Context Relationships on Aesthetic Judgment. PLoS ONE, 3(11). DOI: 10.1371/journal.pone.0003754
Secure ward managers may be able to reduce patient aggression by carefully monitoring the sex ratio of the staff relative to the patients. That's according to Susan Knowles and colleagues who've found that mental health patients held on a medium secure ward were more likely to exhibit physical or verbal aggression to staff of the same sex as themselves.The researchers analysed incident report records kept between 2004 and 2006 by two male-only and two female-only wards at a medium secure unit in........ Read more »
Susan Knowles, Sarah Coyne, & Stephen Brown. (2008) Sex differences in aggressive incidents towards staff in secure services. Journal of Forensic Psychiatry , 19(4), 620-631. DOI: 10.1080/14789940801962130
OK, so that's not how this new study is being headlined elsewhere (e.g. Religious Feelings Associated with Women's Lengthier Survival). But that's essentially what it has shown. Here's what they did (see below for a reference to the paper).... Read more »
Eliezer Schnall, Sylvia Wassertheil-Smoller, Charles Swencionis, Vance Zemon, Lesley Tinker, Mary Jo O'Sullivan, Linda Van Horn, & Mimi Goodwin. (2008) The relationship between religion and cardiovascular outcomes and all-cause mortality in the women's health initiative observational study. Psychology , 1-15. DOI: 10.1080/08870440802311322
D MOCHON, M NORTON, & D ARIELY. (2008) Getting off the hedonic treadmill, one step at a time: The impact of regular religious practice and exercise on well-being. Journal of Economic Psychology, 29(5), 632-642. DOI: 10.1016/j.joep.2007.10.004
Discussion of two new papers on 454 sequencing and microbial diversity... Read more »
Huse, S., Dethlefsen, L., Huber, J., Welch, D., Relman, D., & Sogin, M. (2008) Exploring Microbial Diversity and Taxonomy Using SSU rRNA Hypervariable Tag Sequencing. PLoS Genetics, 4(11). DOI: 10.1371/journal.pgen.1000255
Dethlefsen, L., Huse, S., Sogin, M., & Relman, D. (2008) The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing. PLoS Biology, 6(11). DOI: 10.1371/journal.pbio.0060280
Google is significantly more efficient in searching for specific medical information than other search engines such as Yahoo!, Ask.com and Wikipedia. Moreover, general search engines guide users to websites likely to contain information on a topic of interest with greater efficiency than directly accessing an individual website (eg, Wikipedia, MDconsult and others).
Physicians are concerned about [...]... Read more »
P JOHNSON, J CHEN, J ENG, M MAKARY, & E FISHMAN. (2008) A Comparison of World Wide Web Resources for Identifying Medical Information. Academic Radiology, 15(9), 1165-1172. DOI: 10.1016/j.acra.2008.02.010
Bacterial quorum sensing is not a new phenomenon by any means. Although the term has only recently come into the existence, the concept has been around for decades.In 1964,Tomasz and Hotchkiss, out of Rockefeller, demonstrated the presence of a macromolecule responsible for induction of competence in pneumococcus when the cells reached a specific growth point in mid to late log phase.This concept has been vastly expanded upon and the ramifications of such diffusible communication molecules are v........ Read more »
Bacterial quorum sensing is not a new phenomenon by any means. Although the term has only recently come into the existence, the concept has been around for decades.
In 1964,Tomasz and Hotchkiss, out of Rockefeller, demonstrated the presence of a macromolecule responsible for induction of competence in pneumococcus when the cells reached a specific growth point in mid to late log phase.
This concept has been vastly expanded upon and the ramifications of such diffusible communication molecules........ Read more »
Genome survey sequencing (1.9X coverage) was generated for Moniliophthora perniciosa, the cause of witches' broom disease on cacao plants. The sequence for this basidiomycete plant pathogen was published in BMC Genomics this week. The authors report a higher number of ROS metabolism and P450 genes. Evaluating whether these copy number differences are significantly different from other basidiomycete fungi and are lineage specific expansions will help determine if these families played a role in ........ Read more »
Jorge MC Mondego, Marcelo F Carazzolle, Gustavo GL Costa, Eduardo F Formighieri, Lucas P Parizzi, Johana Rincones, Carolina Cotomacci, Dirce M Carraro, Anderson F Cunha, Helaine Carrer.... (2008) A genome survey of Moniliophthora perniciosa gives new insights into Witches' Broom Disease of cacao. BMC Genomics, 9(1), 548. DOI: 10.1186/1471-2164-9-548
The genome of the extinct woolley mammoth (Mammuthus primigenius) has been sequenced, and reported in Nature. This confirms that elephant genomes are large, like the elephants themselves. It confirms previously proposed relationships amongst the elephants (see phylogeny below) and refines the known phylogeny. Interpopulation differences among mammoths were also demonstrated.
Here's the phylogeny:
Comparison of phylogenies of elephants and hominoids. "We show estimated divergence times, th........ Read more »
Webb Miller, Daniela I. Drautz, Aakrosh Ratan, Barbara Pusey, Ji Qi, Arthur M. Lesk, Lynn P. Tomsho, Michael D. Packard, Fangqing Zhao, Andrei Sher.... (2008) Sequencing the nuclear genome of the extinct woolly mammoth. Nature, 456(7220), 387-390. DOI: 10.1038/nature07446
It used to be accepted as fact that boys are naturally better than girls in math. With time, what was taken as a fact has become an assumption that boys are more inclined to do math than girls. With even more passage of time, studies are shedding light that the differences in achievement between boys [...]... Read more »
David Lubinski, Camilla P. Benbow, Rose Mary Webb, & April Bleske-Rechek. (2006) Tracking Exceptional Human Capital Over Two Decades. Psychological Science, 17(3), 194-199. DOI: 10.1111/j.1467-9280.2006.01685.x
Graves of children and adults were found in Eulau, Germany that were about 4,600 years old. This group of people is considered to be part what is called the Corded Ware Culture which flourished during the Copper Age.The people buried at this site seem to have died a violent death. Some had crushed skulls while others exhibited defense wounds on their forearms. There have been similar mass graves found (such as Talheim, Germany) where the victims were murdered and then just thrown into mass g........ Read more »
W. Haak, G. Brandt, H. N. de Jong, C. Meyer, R. Ganslmeier, V. Heyd, C. Hawkesworth, A. W. G. Pike, H. Meller, & K. W. Alt. (2008) Ancient DNA, Strontium isotopes, and osteological analyses shed light on social and kinship organization of the Later Stone Age. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0807592105
A new genetic technology has been developed at Harvard HHMI that allow tracking the stability of individual proteins within a complex (omics) mixture. Sherry Yen and colleagues, introduced in Science magazine the Global Protein Stability (GPS), a parallel multiplexing strategy to simultaneously measure the half-lives of thousands of proteins in mammalian cells. Of course, the core is based on two fluorescent reporters (DsRed and EGFP), so we can provocatively name it reportergenomics. How does i........ Read more »
H.-C. S. Yen, Q. Xu, D. M. Chou, Z. Zhao, & S. J. Elledge. (2008) Global Protein Stability Profiling in Mammalian Cells. Science, 322(5903), 918-923. DOI: 10.1126/science.1160489
Results of clinical trials can sometimes not only change our understanding of the condition studied, but may also affect the way we practice medicine. The Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) is such a study.... Read more »
P. M Ridker, E. Danielson, F. A.H. Fonseca, J. Genest, A. M. Gotto, J. J.P. Kastelein, W. Koenig, P. Libby, A. J. Lorenzatti, J. G. MacFadyen.... (2008) Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein. New England Journal of Medicine, 359(21), 2195-2207. DOI: 10.1056/NEJMoa0807646
M. A. Hlatky. (2008) Expanding the Orbit of Primary Prevention -- Moving beyond JUPITER. New England Journal of Medicine, 359(21), 2280-2282. DOI: 10.1056/NEJMe0808320
N. Donner-Banzhoff, & A. Sonnichsen. (2008) Statins and primary prevention of cardiovascular events. BMJ, 337(nov14 2). DOI: 10.1136/bmj.a2576
A wonderful paper on the subject of heat. Not a recent publication but a fascinating one nonetheless!... Read more »
Benjamin Count of Rumford. (1798) An Inquiry concerning the Source of the Heat Which is Excited by Friction. Philosophical Transactions of the Royal Society of London, 80-102. DOI: http://www.jstor.org/stable/106970
A protist is a single celled eukaryotic organism, and they are usually pretty small. You can often see them, though! Before you put that sample of pond water under the microscope, take a close look: Many protists are at the boundary of visibility for humans.
Then, there are the giant protists, grape size, living on the bottom of the sea where they roll around in the mud. It has been known for some time that there are giant deep sea protazoans that are not mobile. Here, though, is a bit o........ Read more »
M MATZ, T FRANK, N MARSHALL, E WIDDER, & S JOHNSEN. (2008) Giant Deep-Sea Protist Produces Bilaterian-like Traces. Current Biology. DOI: 10.1016/j.cub.2008.10.028
This interesting paper investigates whether there is a relationship between polyandry and selfish genetic elements, in the fruit fly Drosophila pseudoobscura. Polyandry - where females have multiple mating partners - is widespread in animals, but despite its frequency, little is known of the costs and benefits of this reproductive strategy ( [...]... Read more »
T. A. R. Price, D. J. Hodgson, Z. Lewis, G. D. D. Hurst, & N. Wedell. (2008) Selfish Genetic Elements Promote Polyandry in a Fly. Science, 322(5905), 1241-1243. DOI: 10.1126/science.1163766
Upon first read, a new study about the contribution of "black carbon" to the global carbon cycle, and therefore to climate change, suggests things might not be as bad as now commonly thought. But first reads, especially by those who don't have a graduate degree specializing in exactly the field in question, can be misleading. And "Australian climate-carbon cycle feedback reduced by soil black carbon," which appears in the latest Nature Geoscience, is a case in point. Read the rest of this post.......... Read more »
Johannes Lehmann, Jan Skjemstad, Saran Sohi, John Carter, Michele Barson, Pete Falloon, Kevin Coleman, Peter Woodbury, & Evelyn Krull. (2008) Australian climate–carbon cycle feedback reduced by soil black carbon. Nature Geoscience. DOI: 10.1038/ngeo358
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