A study published in the New England Journal of Medicine describes an autoinflammatory syndrome associated with mutations in the gene encoding STING. Dubbed SAVI, for STING-associated vasculopathy with onset in infancy, the disease is characterized by systemic inflammation, severe cutaneous … Continue reading →... Read more »
Liu, Y., Jesus, A., Marrero, B., Yang, D., Ramsey, S., Sanchez, G., Tenbrock, K., Wittkowski, H., Jones, O., Kuehn, H.... (2014) Activated STING in a Vascular and Pulmonary Syndrome. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1312625
One of the more common (though often frustrating) questions we get in archaeology is “Why are you doing historic archaeology? We already know what happened”. To some extent, for eras […]... Read more »
Bigman, D. (2013) Mapping social relationships: geophysical survey of a nineteenth-century American slave cemetery. Archaeological and Anthropological Sciences, 6(1), 17-30. DOI: 10.1007/s12520-013-0119-6
“Hey al im on my way 2wrk but i totes 4got 2bring ur ipod sori il hav 2 bring it nxt tym ur workin. Hav a nice day xo”
Gives you the cramps? Maybe you should read this article.... Read more »
Grace, A., Kemp, N., Martin, F., & Parrila, R. (2013) Undergraduates' attitudes to text messaging language use and intrusions of textisms into formal writing. New Media . DOI: 10.1177/1461444813516832
Thompson, C., Gray, K., & Kim, H. (2014) How social are social media technologies (SMTs)? A linguistic analysis of university students' experiences of using SMTs for learning. The Internet and Higher Education, 31-40. DOI: 10.1016/j.iheduc.2013.12.001
In the beginning, there was no sex. That’s because in the beginning, there was no Barry White. A playful look at examples of homosexuality in nature.... Read more »
Rice WR, Friberg U, & Gavrilets S. (2012) Homosexuality as a consequence of epigenetically canalized sexual development. The Quarterly review of biology, 87(4), 343-68. PMID: 23397798
Although it might seem a good idea to work with other people to remember important information, the evidence suggests that this typically isn't so. Individual recall is most efficient whereas social remembering comes with drawbacks, tripping up our flow and inhibiting memories. But this evidence mostly comes from asking people to collaborate with a stranger. What happens when you know each other really, really well?Celia Harris and colleagues at Macquarie University recently reviewed their previ........ Read more »
Harris, C., Barnier, A., Sutton, J., & Keil, P. (2014) Couples as socially distributed cognitive systems: Remembering in everyday social and material contexts. Memory Studies, 7(3), 285-297. DOI: 10.1177/1750698014530619
A brief entry today and yet another blog post that starts with a quote (sorry)... "The offspring exposed to VPA [valproic acid] prenatally demonstrated a significant decrease in the number of play initiations/attacks and this was reversed with the KD [ketogenic diet]".Gloucester Old Spot @ Wikipedia That finding reported in the paper by Ahn and colleagues  continues my interest in all-things related to prenatal VPA exposure and the reported effects on some offspring (........ Read more »
Ahn Y, Narous M, Tobias R, Rho JM, & Mychasiuk R. (2014) The Ketogenic Diet Modifies Social and Metabolic Alterations Identified in the Prenatal Valproic Acid Model of Autism Spectrum Disorder. Developmental neuroscience. PMID: 25011527
Miguel Ramalho-Santos, PhDA new stem-cell discovery might one day lead to a more streamlined process for obtaining stem cells, which in turn could be used in the development of replacement tissue for failing body parts, according to UC San Francisco scientists who reported the findings in the current edition of Cell.The research builds on a strategy that involves reprogramming adult cells back to an embryonic state in which they again have the potential to become any type of cell.The efficiency ........ Read more »
Qin, H., Diaz, A., Blouin, L., Lebbink, R., Patena, W., Tanbun, P., LeProust, E., McManus, M., Song, J., & Ramalho-Santos, M. (2014) Systematic Identification of Barriers to Human iPSC Generation. Cell, 158(2), 449-461. DOI: 10.1016/j.cell.2014.05.040
Attention deficit hyperactivity disorder (ADHD), characterized by inattention, hyperactivity, and impulsivity, is a common childhood disorder. ADHD can often persist into adolescence and adulthood. The prevalence of ADHD is thought to be between 6-7% among children and adolescents and ~5% among adults (Willcutt, 2012).
Increasingly, evidence from multiple studies has pointed to comorbidity between ADHD and eating disorders (EDs). For example, one study found that young females with ADHD we........ Read more »
Bleck, J., DeBate, R., & Olivardia, R. (2014) The Comorbidity of ADHD and Eating Disorders in a Nationally Representative Sample. The Journal of Behavioral Health Services . DOI: 10.1007/s11414-014-9422-y
A new study from Colombia sees Blastocystis as a quasi-ubiquitous organism.... Read more »
Londoño-Franco AL, Loaiza-Herrera J, Lora-Suárez FM, & Gómez-Marín JE. (2014) [Blastocystis sp . frequency and sources among children from 0 to 5 years of age attending public day care centers in Calarcá, Colombia]. Biomedica : revista del Instituto Nacional de Salud, 34(2), 218-27. PMID: 24967927
Klimeš V, Gentekaki E, Roger AJ, & Eliáš M. (2014) A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons. Genome biology and evolution. PMID: 25015079
Lukeš J, Kuchta R, Scholz T, & Pomajbíková K. (2014) (Self-) infections with parasites: re-interpretations for the present. Trends in parasitology. PMID: 25033775
Tomasini N, Lauthier JJ, Ayala FJ, Tibayrenc M, & Diosque P. (2014) How often do they have sex? A comparative analysis of the population structure of seven eukaryotic microbial pathogens. PloS one, 9(7). PMID: 25054834
Okay, not quite all of them. But it looks like Misha Ahrens and Jeremy Freeman are going to continue their reign of terror, imaging the whole zebrafish brain as if it’s no big deal. Yeah they’ve got almost every neuron of a vertebrate, so what? Besides figuring out that not shooting light at the eyes might […]... Read more »
Freeman, J., Vladimirov, N., Kawashima, T., Mu, Y., Sofroniew, N., Bennett, D., Rosen, J., Yang, C., Looger, L., & Ahrens, M. (2014) Mapping brain activity at scale with cluster computing. Nature Methods. DOI: 10.1038/nmeth.3041
Vladimirov, N., Mu, Y., Kawashima, T., Bennett, D., Yang, C., Looger, L., Keller, P., Freeman, J., & Ahrens, M. (2014) Light-sheet functional imaging in fictively behaving zebrafish. Nature Methods. DOI: 10.1038/nmeth.3040
Well this might seem weird, but today is world hepatitis day. I guess I should qualify weird with the fact that it’s only weird because no one really knows. What […]... Read more »
Lawitz, E., Sulkowski, M., Ghalib, R., Rodriguez-Torres, M., Younossi, Z., Corregidor, A., DeJesus, E., Pearlman, B., Rabinovitz, M., Gitlin, N.... (2014) Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study. The Lancet. DOI: 10.1016/S0140-6736(14)61036-9
C. Ronald KahnIn 2012, Japanese biologist Shinya Yamanaka won a Nobel Prize for discovering the so-called induced pluripotent stem cells" (iPSCs), cells derived from normal adult cells that have the ability to differentiate into almost any other kind of cells. Now, researchers at Joslin Diabetes Center say they have created the first iPSCs line that offers a human model for insulin resistance, a key driver of type 2 diabetes. "This is one of the very first studies of human iPSC models ........ Read more »
Iovino S, Burkart AM, Kriauciunas K, Warren L, Hughes KJ, Molla M, Lee YK, Patti ME, & Kahn CR. (2014) Genetic Insulin Resistance is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells. Diabetes. PMID: 25059784
Looking at computers with eyeglasses strains your eyes, so scientists are making computers that help your eyes out.... Read more »
How well can psychotherapists and their clients judge from personal experience whether therapy has been effective? Not well at all, according to a paper by Scott Lilienfeld and his colleagues. The fear is that this can lead to the continued practice of ineffective, or even harmful, treatments.The authors point out that, like the rest of us, clinicians are subject to four main biases that skew their ability to infer the effectiveness of their psychotherapeutic treatments. This includes the mistak........ Read more »
Lilienfeld, S., Ritschel, L., Lynn, S., Cautin, R., & Latzman, R. (2014) Why Ineffective Psychotherapies Appear to Work: A Taxonomy of Causes of Spurious Therapeutic Effectiveness. Perspectives on Psychological Science, 9(4), 355-387. DOI: 10.1177/1745691614535216
Emphasis mine: A substantial proportion of donors reported a moderate-to-severe level of pain intensity (> 4 on a 0-10 scale) at rest and at movement on day one (42%, 74%) and day two (33%, 32%). Persistent post-surgical pain was reported by 31% of donors at the six-month follow-up and by 27% of donors at …
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The post Chronic Pain in Live Liver Donors appeared first on Living Donors Are People Too.
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Holtzman S, Clarke HA, McCluskey SA, Turcotte K, Grant D, & Katz J. (2014) Acute and chronic post-surgical pain after live liver donation: Incidence and predictors. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. PMID: 25045167
Most of us now subscribe to the idea that plastic bags are bad for the environment. Hence, droves of people turn up at their local supermarket with a sturdy jute bag in tow. Now, there’s evidence that the items that … Continue reading →... Read more »
Nerin C, Ubeda JL, Alfaro P, Dahmani Y, Aznar M, Canellas E, & Ausejo R. (2014) Compounds from multilayer plastic bags cause reproductive failures in artificial insemination. Scientific reports, 4913. PMID: 24810330
Researchers at the Lawrence Livermore National Laboratory and Rice University have created a theoretical model that predicts how carbon components will perform as anodes in lithium-ion batteries.... Read more »
Liu, Y., Wang, Y., Yakobson, B., & Wood, B. (2014) Assessing Carbon-Based Anodes for Lithium-Ion Batteries: A Universal Description of Charge-Transfer Binding. Physical Review Letters, 113(2). DOI: 10.1103/PhysRevLett.113.028304
Do I still believe in evidence based orthodontics? Every now and then a paper comes along that makes me stop and think about how I practice and what I have taught over the past thirty years. Professor Trisha Greenhalgh and colleagues published one of these papers in the British Medical Journal several weeks ago. I […]
The post Do I still believe in evidence based orthodontics? appeared first on Kevin O'Brien's Orthodontic Blog.
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Acknowledging that some topics have the ability to furrow brows when it comes to autism research, mercury and autism is becoming something of a frequent talking point on this blog as a function of a whole slew of articles appearing in the peer-reviewed domain. If I were to [very tentatively] summarise the collected literature so far, it would be to say something like:Mosaic of mercury @ Wikipedia (i) there is quite a bit more research to be done on some sources of mercury being 'l........ Read more »
Yau VM, Green PG, Alaimo CP, Yoshida CK, Lutsky M, Windham GC, Delorenze G, Kharrazi M, Grether JK, & Croen LA. (2014) Prenatal and neonatal peripheral blood mercury levels and autism spectrum disorders. Environmental research, 294-303. PMID: 24981828
Technology has been racing forward at an ever increasing rate. Unfortunately, anyone who owns a smartphone will tell you that the battery life doesn’t match the advancements. That is probably […]... Read more »
Liu N, Lu Z, Zhao J, McDowell MT, Lee HW, Zhao W, & Cui Y. (2014) A pomegranate-inspired nanoscale design for large-volume-change lithium battery anodes. Nature nanotechnology, 9(3), 187-92. PMID: 24531496
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