Lots of recent evidence is demonstrating that lingual taste buds are just the tip of the iceberg. Taste receptors have been identified in parts of the respiratory, gastrointestinal, renal, and nervous systems. Taste receptor functions in non-gustatory tissues are related to feeding and hunger, nutrient sensing, and protective responses.
Studies have shown that the pancreas has umami and sweet receptors that work in insulin release. The gut has receptors for fat, umami, sweet and bitter. The........ Read more »
Sundaresan S, Shahid R, Riehl TE, Chandra R, Nassir F, Stenson WF, Liddle RA, & Abumrad NA. (2013) CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(3), 1191-202. PMID: 23233532
Kyriazis GA, Soundarapandian MM, & Tyrberg B. (2012) Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proceedings of the National Academy of Sciences of the United States of America, 109(8). PMID: 22315413
Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, Deberardinis RJ, Cobb MH. (2012) The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol Cell., 47(6), 851-862. DOI: 10.1016/j.molcel.2012.08.001
Dehkordi O, Rose JE, Fatemi M, Allard JS, Balan KV, Young JK, Fatima S, Millis RM, & Jayam-Trouth A. (2012) Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem. Brain research, 1-10. PMID: 22836012
Astronomers have reported the discovery of one of the most distant galaxies, dubbed Abell2744 Y1.
Astronomy and Astrophysics Letters
Redshift and previous findings:
Redshift refers to a shift in the spectrum of a celestial body toward longer wavelengths, or toward the red end of the spectrum, caused by its motion away from the Earth.
Previously, scientists reported a galaxy dubbed MACS1149-JD1 at a redshift of about 10, i.e. the galax........ Read more »
N. Laporte, A. Streblyanska, B. Clement, I. Pérez-Fournon, D. Schaerer, H. Atek, F. Boone, J.-P. Kneib, E. Egami, P. Martínez-Navajas, R. Marques-Chaves, R. Pelló, J. Richard. (2014) The first Frontier Fields cluster: 4.5mum excess in a z-8 galaxy candidate in Abell 2744 . Astronomy . DOI: 10.1051/0004-6361/201323179
Satellite technology reveals for the first time the diving behaviour of the mysterious reef manta ray.... Read more »
Braun CD, Skomal GB, Thorrold SR, & Berumen ML. (2014) Diving behavior of the reef manta ray links coral reefs with adjacent deep pelagic habitats. PLoS ONE, 9(2). PMID: 24516605
Scientists identify gene linking brain structure to intelligence
... Read more »
Desrivières S, Lourdusamy A, Tao C, Toro R, Jia T, Loth E, Medina LM, Kepa A, Fernandes A, Ruggeri B.... (2014) Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. Molecular psychiatry. PMID: 24514566
There are some research models whose names seem silly, or at least named for a Taylor Swift song. Oddly enough, there is a large body of research on those who are “habitually sensitive toward victimization” and it turns out they tend to be uncooperative and immoral in “socially uncertain situations”. Apparently, the suspicion and mistrust […]
Empathy: Paving the road to preferential treatment with good intentions
Shooting the messenger: The intergroup sensitivity ef........ Read more »
Gollwitzer, M., Rothmund, T., & Süssenbach, P. (2013) The sensitivity to mean intentions (SeMI) model: Basic assumptions, recent findings, and potential avenues for future research. Social and Personality Psychology Compass, 415-426. DOI: 10.1111/spc3.12041
White matter fiber architecture of the brain. Human Connectome Project.A new study by researchers at the University of California, Berkeley has shown that chronic stress generates long-term changes in the brain that may explain why people suffering chronic stress are prone to mental problems such as anxiety and mood disorders later in life.The findings could lead to new therapies to reduce the risk of developing mental illness after stressful events.It's long known that people with stress-re........ Read more »
Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty AC, Krishnamurthy A.... (2014) Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Molecular psychiatry. PMID: 24514565
A new method that couples microfluidics and super-resolution microscopy to image live bacteria at unsurpassed spatial and temporal resolutions has been developed. Uniquely, this technology considerably improves cell stability, allows for long time-lapse imaging and completely eliminates chromatic aberrations.
HFSP Career Development Award holder Marcelo Nollmann and Young Investigator Grant holder Tam Mignot and colleagues
Awardees Articles February 11, 2014 Human Frontier Science Program... Read more »
Diego I. Cattoni, Jean-Bernard Fiche, Alessandro Valeri, Tâm Mignot, Marcelo Nöllmann. (2013) Super-Resolution Imaging of Bacteria in a Microfluidics Device. PLOS ONE. DOI: 10.1371/journal.pone.0076268
Research Bloggingについてまとめた論文を紹介するとともに，Research Bloggingがどのような仕組みであるかを説明し，日本でも需要があり得るサービスであることを指摘．... Read more »
Fausto S, Machado FA, Bento LF, Iamarino A, Nahas TR, & Munger DS. (2012) Research blogging: indexing and registering the change in science 2.0. PloS one, 7(12). PMID: 23251358
Many athletes especially football players suffer exertional heat stroke each year To reduce the prevalence of exertional heat stroke, clinicians should be well educated on, and implement active exertional heat stroke management strategies such as moving the athletes into air conditioning, cold water immersion, and monitoring body temperature.... Read more »
Kerr ZY, Marshall SW, Comstock RD, & Casa DJ. (2014) Exertional heat stroke management strategies in United States high school football. The American Journal of Sports Medicine, 42(1), 70-7. PMID: 24013346
Aberrations in the enzymes that modify ubiquitin moieties have been observed to cause a myriad of diseases, including cancer. Therefore a better understanding of these enzymes and their substrates will lead to the identification of prospective druggable targets. Here we discuss the role of ubiquitin modifying enzymes in the canonical TGF-β pathway highlighting the ubiquitin regulating enzymes, which may potentially be targeted by small molecule inhibitors.
... Read more »
Prasanna Vasudevan Iyengar, Pieter Johan Adam Eichhorn*. (2013) (DE) -Ubiquitination in The TGF-ß Pathway. Journal of Cancer Research and Therapeutic Oncology, 1(1), 1-6. info:other/1:102
Unfortunately, I’ve been too busy to attend to Inspiring Science this week. Rather than putting out a rushed post, I …Continue reading »... Read more »
Fisher DO, Dickman CR, Jones ME, & Blomberg SP. (2013) Sperm competition drives the evolution of suicidal reproduction in mammals. Proceedings of the National Academy of Sciences of the United States of America, 110(44), 17910-4. PMID: 24101455
So: "The findings of this review suggest that the etiology of ASD [autism spectrum disorder] may involve, at least in a subset of children, complex interactions between genetic factors and certain environmental toxicants that may act synergistically or in parallel during critical periods of neurodevelopment, in a manner that increases the likelihood of developing ASD".That's the conclusion reached by a huge review paper by Dan Rossignol and colleagues* (open-access). I'm going to say no mor........ Read more »
D A Rossignol, S J Genuis, & R E Frye. (2014) Environmental toxicants and autism spectrum disorders: a systematic review. Translational Psychiatry. DOI: 10.1038/tp.2014.4
The recent study "Silent Listeners: The Evolution of Privacy and Disclosure on Facebook" conducted by researchers at Carnegie Mellon University monitored the public disclosure (information visible to all) and private disclosure (information visible to Facebook friends) of personal data by more than 5,000 Facebook users during the time period 2005-2011. ... Read more »
Fred Stutzman, Ralph Grossy, & Alessandro Acquistiz. (2012) Silent Listeners: The Evolution of Privacy and Disclosure on Facebook. Journal of Privacy and Confidentiality. info:/
Children who live near overhead power lines in early life do not have a greater risk of developing childhood leukemia, researchers from the Childhood Cancer Research Group at the University of Oxford have found.... Read more »
Bunch K.J., Keegan T.J., Swanson J., Vincent T.J., & Murphy M.F. (2014) Residential distance at birth from overhead high-voltage powerlines: childhood cancer risk in Britain 1962-2008. British Journal of Cancer. PMID: 24504371
It’s not the reason you’d guess. They make perfectly pleasant-smelling neighbors. Yet skunks and other animals that use projectile stink as a weapon are apparently destined by evolution to be loners—not because of who they are, but because of who preys on them. Ted Stankowich, who studies the intersection of evolution, animal behavior and ecology […]The post Why Stinky Animals Live Alone appeared first on Inkfish.... Read more »
Stankowich T, Haverkamp PJ, & Caro T. (2014) ECOLOGICAL DRIVERS OF ANTIPREDATOR DEFENSES IN CARNIVORES. Evolution; international journal of organic evolution. PMID: 24433406
Cross-section through the bone marrow of a mouse lacking the Ikaros protein.Credit: Research Institute of Molecular PathologyMeinrad Busslinger and his research team at the Institute of Molecular Pathology (IMP) investigate the differentiation of stem cells to mature B cells. They now present for the first time molecular details on the role of the Ikaros gene during early B cell development.A defect in Ikaros function causes an early block in B-lymphopoiesis and prevents the development of matu........ Read more »
Tanja A Schwickert, Hiromi Tagoh, Sinan Gültekin, Aleksandar Dakic, Elin Axelsson, Martina Minnich, Anja Ebert, Barbara Werner, Mareike Roth, Luisa Cimmino, Ross A Dickins, Johannes Zuber, Markus Jaritz, Meinrad Busslinger. (2013) Stage-specific control of early B cell development by the transcription factor Ikaros. Nature Immunology. DOI: 10.1038/ni.2828
The beneficial effects of exercise on the brain has received significant research attention in children and older adults.Fewer research studies target young and middle aged adults.William Killgore and colleagues recently addressed this population in a study published in Scientific Reports.They preformed a cross-sectional correlation study of brain structure and self-reported exercise habits.Sixty one men and women between the ages of 18 and 45 years of age were recruited for the study.Subjects w........ Read more »
Killgore WD, Olson EA, & Weber M. (2013) Physical exercise habits correlate with gray matter volume of the hippocampus in healthy adult humans. Scientific reports, 3457. PMID: 24336512
Researchers found that dairy product intake is associated with a lower risk of type 2 diabetes. They not only examined the risk of diabetes in relation to consumption of total dairy products, but also distinguished between different dairy products.... Read more »
O'Connor LM, Lentjes MA, Luben RN, Khaw KT, Wareham NJ, & Forouhi NG. (2014) Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary. Diabetologia. PMID: 24510203
NASA spacecraft revolving around and studying Mars have found the strongest indications of water flows on Mars while studying seasonal features.
Geophysical Research Letters
In a study by NASA’s Mars Opportunity Rover, it has been observed that water was present on Mars about four billion years ago that was probably supportive of life (DOI: 10.1126/science.1248097)
Now scientists have found some indications of water on Mars in cer........ Read more »
R. E. Arvidson et al. (2014) Ancient Aqueous Environments at Endeavour Crater, Mars. Science. DOI: 10.1126/science.1248097
How does a man feel if another man opens a door for him? The researchers Megan McCarty and Janice Kelly conducted a field study to find out.Male research assistants waited near two university building entrances and looked out for men and women approaching. On some trials the research assistant went through a door adjacent to the arriving person (so that the person had to open the door for themselves). On other trials, the research assistant leaped into action, held open the door for the approach........ Read more »
Megan McCarty, & Janice R. Kelly. (2014) When door holding harms: gender and the consequences of non-normative help. Social Influence. DOI: 10.1080/15534510.2013.869252
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