Last week the US National Cancer Institute announced a phase II clinical trial to test everolimus, a derivative of rapamycin, in BHD patients with renal cell carcinoma (RCC). The trial is also open to sporadic chromophobe RCC (chRCC) patients. Approximately 85% of BHD-RCC is either chRCC or a chromophobe-oncocytoma hybrid (Pavlovich et al., 2002), but there are no effective treatments available for this RCC subtype. Instead BHD patients undergo partial nephrectomies to excise tumours – whi........ Read more »
Benusiglio PR, Giraud S, Deveaux S, Méjean A, Correas JM, Joly D, Timsit MO, Ferlicot S, Verkarre V, Abadie C.... (2014) Renal cell tumour characteristics in patients with the Birt-Hogg-Dubé cancer susceptibility syndrome: a retrospective, multicentre study. Orphanet journal of rare diseases, 163. PMID: 25519458
I should perhaps begin this slightly longer than usual post by reiterating my well-trodden caveat on this blog about not giving anything that looks, sounds or smells like medical or clinical advice during my musings. This is a blog [mainly] about peer-reviewed science, nothing more. Added to that, I'm not your Dr Ross and you are not my patient.So... I've been seeing quite a bit about Gc-MAF (Gc Macrophage Activating Factor) in the news recently. The various headlines about autism and Gc-MAF (se........ Read more »
Inui T, Kubo K, Kuchiike D, Uto Y, Nishikata T, Sakamoto N, & Mette M. (2015) Oral Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue Syndrome: Three Case Reports. Anticancer research, 35(8), 4545-9. PMID: 26168499
MedicalResearch.com Interview with: Alan Cheng, MD, FACC, FAHA, FHRS Associate Professor of Medicine and Pediatrics Director, Arrhythmia Device Service Johns Hopkins University School of Medicine Baltimore, MD Medical Research: What is the background for this study? What are the main … Continue reading →
The post How To Handle ICD If Patient’s Heart Function Improves? appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Alan Cheng, MD, FACC, FAHA, FHRS. (2015) How To Handle ICD If Patient's Heart Function Improves?. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Gwendolyn P. Quinn, Ph.D. Moffitt Cancer Center University of South Florida MedicalResearch: What is the background for this study? What are the main findings? Dr. Quinn: Our research group has been conducting studies of the LGBTQ community … Continue reading →
The post 7 Cancers May Occur More Frequently In LGBTQ Community appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Gwendolyn P. Quinn, Ph.D. (2015) 7 Cancers May Occur More Frequently In LGBTQ Community. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Karla M. Gonye, MBA President, sphingotec LLC Cambridge, Massachusetts MedicalResearch: What is the background for this study? Response: Met- and Leu-Enkephalin: are endogenous pentapeptides of the family of opioid peptides known as opiod-growth factors (OGF) Enkephalins have … Continue reading →
The post Plasma Biomarker May Be Independent Risk Predictor of Breast Cancer In Women Without Family History appeared first on MedicalResearch.com Medical........ Read more »
Karla M. Gonye, MBA. (2015) Plasma Biomarker May Be Independent Risk Predictor of Breast Cancer In Women Without Family History. MedicalResearch.com. info:/
Serious question: has the peer review system at the PLOS journals been doing a less-than-stellar job when it comes to evaluating complementary and alternative medicine (CAM) research for publication? If the answer is 'yes', why? Or if 'no', how does a paper like this go through PLOS ONE without some serious revisions?... Read more »
Zhao, X., Hu, H., Li, J., Shang, H., Zheng, H., Niu, J., Shi, X., & Wang, S. (2015) Is Acupuncture Effective for Hypertension? A Systematic Review and Meta-Analysis. PLOS ONE, 10(7). DOI: 10.1371/journal.pone.0127019
MedicalResearch.com Interview with: Alexander C. Tsai, MD, PhD Center for Global Health Massachusetts General Hospital, Boston Harvard Center for Population and Development Studies Cambridge, Massachusetts Medical Research: What is the background for this study? What are the main findings? Dr. Tsai: Suicide … Continue reading →
The post Socially Isolated Women Have Greater Risk of Suicide appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Alexander C. Tsai, MD, PhD. (2015) Association Between Social Integration and Suicide Among Women in the United States. MedicalResearch.com. info:/
Five men with complete motor paralysis were able to voluntarily generate step-like movements thanks to a new strategy that non-invasively delivers electrical stimulation to their spinal cords. The strategy, called transcutaneous stimulation, delivers electrical current to the spinal cord by way of electrodes strategically placed on the skin of the lower back.... Read more »
Gerasimenko, Y., Lu, D., Modaber, M., Zdunowski, S., Gad, P., Sayenko, D., Morikawa, E., Haakana, P., Ferguson, A., Roy, R.... (2015) Noninvasive Reactivation of Motor Descending Control after Paralysis. Journal of Neurotrauma, 2147483647. DOI: 10.1089/neu.2015.4008
Cupriavidus metallidurans (roughly translated: lover of copper, enduring metal) is a bacterium of the class Betaproteobacteria known for its ability to withstand high concentrations of numerous metals that would be toxic to most other living things. These metals, which include Ag, Au, Bi, Cd, Co, Cr, Cs, Cu, Hg, Ni, Pb, Sr, Tl, U, and Zn, tend to cause problems for bacterial cells by binding to DNA or proteins, which can disrupt important stuff like obtaining energy or reproducing.The bacterium ........ Read more »
Phillips G, Reith F, Qualls C, Ali AM, Spilde M, & Appenzeller O. (2010) Bacterial deposition of gold on hair: Archeological, forensic and toxicological implications. PloS One, 5(2). PMID: 20174476
Wiesemann N, Mohr J, Grosse C, Herzberg M, Hause G, Reith F, & Nies DH. (2013) Influence of copper resistance determinants on gold transformation by Cupriavidus metallidurans strain CH34. Journal of Bacteriology, 195(10), 2298-308. PMID: 23475973
Over the course of my PhD work (published here, and most recently here), I have found evidence for evolved differences in phenotype (in other words, in their morphology, development, phenology, stress responses) between native and invasive populations of diffuse knapweed. … Continue reading →... Read more »
Joshi, J., & Vrieling, K. (2005) The enemy release and EICA hypothesis revisited: incorporating the fundamental difference between specialist and generalist herbivores. Ecology Letters, 8(7), 704-714. DOI: 10.1111/j.1461-0248.2005.00769.x
Petitpierre B, Kueffer C, Broennimann O, Randin C, Daehler C, & Guisan A. (2012) Climatic niche shifts are rare among terrestrial plant invaders. Science (New York, N.Y.), 335(6074), 1344-8. PMID: 22422981
Turner, K., Fréville, H., & Rieseberg, L. (2015) Adaptive plasticity and niche expansion in an invasive thistle. Ecology and Evolution. DOI: 10.1002/ece3.1599
De novo mutations — sequence variants that are present in a child but absent from both parents — are an important source of human genetic variation. I think it’s reasonable to say that most of the 3-4 million variants in any individual’s genome arose, once upon a time, as de novo mutations in his or her ancestors. […]... Read more »
Francioli LC, Polak PP, Koren A, Menelaou A, Chun S, Renkens I, Genome of the Netherlands Consortium, van Duijn CM, Swertz M, Wijmenga C.... (2015) Genome-wide patterns and properties of de novo mutations in humans. Nature genetics, 47(7), 822-6. PMID: 25985141
By guest blogger Jordan Gaines LewisFor over 15 years now, I’ve faithfully kept a diary. Every night, from age 11 until my senior year of university, I snuggled into my bedsheets and rehashed the day’s events before nodding off to sleep. Even though I’m more likely to scribble down my thoughts just once or twice a week nowadays, I’ve found that writing in a diary before bed is a fun way to capture my memories – no matter how frivolous – to enjoy again years down the road.Now a new st........ Read more »
Szőllősi, �., Keresztes, A., Conway, M., & Racsmány, M. (2015) A diary after dinner: How the time of event recording influences later accessibility of diary events. The Quarterly Journal of Experimental Psychology, 1-6. DOI: 10.1080/17470218.2015.1058403
A quote to begin today's post:"Across each population with different kinds of ascertainment, there was a consistent and statistically significant increased prevalence of IBD [inflammatory bowel disease] in patients with ASD [autism spectrum disorder] than their respective controls and nationally reported rates for pediatric IBD."That was the conclusion reached in the paper published by Finale Doshi-Velez and colleagues  including one very notable name on the authorship list, Is........ Read more »
Doshi-Velez F, Avillach P, Palmer N, Bousvaros A, Ge Y, Fox K, Steinberg G, Spettell C, Juster I, & Kohane I. (2015) Prevalence of Inflammatory Bowel Disease Among Patients with Autism Spectrum Disorders. Inflammatory bowel diseases. PMID: 26218138
MedicalResearch.com Interview with: Dr. Monika Pogorzelska-Maziarz PhD MPH Thomas Jefferson University, Jefferson School of Nursing Philadelphia, PA 19107 Medical Research: What is the background for this study? What are the main findings? Dr. Pogorzelska-Maziarz: Sharps disposal containers are ubiquitous in healthcare … Continue reading →
The post Single Use Sharps Recycling Many Reduce C. diff Infections appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Dr. Monika Pogorzelska-Maziarz PhD MPH. (2015) Single Use Sharps Recycling Many Reduce C. diff Infections. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Raveendhara R Bannuru MD, PhD, FAGE Director, Center for Treatment Comparison and Integrative Analysis (CTCIA) Asst Professor of Medicine, Tufts University School of Medicine Special & Scientific Staff, Center for Arthritis and Rheumatic Diseases Tufts Medical Center … Continue reading →
The post Topical and Injected Placebos More Effective Than Pills appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Raveendhara R Bannuru MD, PhD, FAGE. (2015) Topical and Injected Placebos More Effective Than Pills. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Jared Fox, PhD CDC Office of the Associate Director for Policy Medical Research: What is the background for this study? What are the main findings? Dr. Fox: Increasing the number of people who get preventive care is … Continue reading →
The post Patients With Health Insurance Receive Up To Triple Amount Of Preventive Care appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Jared Fox, PhD. (2015) Patients With Health Insurance Receive Up To Triple Amount Of Preventive Care. MedicalResearch.com. info:/
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell. The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.... Read more »
Orelle, C., Carlson, E., Szal, T., Florin, T., Jewett, M., & Mankin, A. (2015) Protein synthesis by ribosomes with tethered subunits. Nature. DOI: 10.1038/nature14862
Cancer Research UK scientists have for the first time identified that there are five distinct types of prostate cancer and found a way to distinguish between them, according to a landmark study. The findings could have important implications for how doctors treat prostate cancer in the future, by identifying tumours that are more likely to grow and spread aggressively through the body.... Read more »
Ross-Adams, H., Lamb, A., Dunning, M., Halim, S., Lindberg, J., Massie, C., Egevad, L., Russell, R., Ramos-Montoya, A., Vowler, S.... (2015) Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study. EBioMedicine. DOI: 10.1016/j.ebiom.2015.07.017
MedicalResearch.com Interview with: Conrad Earnest, PhD, FACSM Texas A&M University College Station, TX Medical Research: What is the background for this study? Dr. Earnest: The study presented here is a thesis project performed by Robbyne Smith and Sammy Licence, under … Continue reading →
The post Walking While Texting Can Be Dangerous To Your Health appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Conrad Earnest, PhD, FACSM. (2015) Walking While Texting Can Be Dangerous To Your Health. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Karla M. Gonye, MBA President, Sphingotec LLC Cambridge, Massachusetts MedicalResearch: What is the background for this study? Response: In experimental studies, Neurotensin and neurotensin expression was highly associated to breast cancer tissue Dupouy et al (2009) investigated … Continue reading →
The post Elevated Neurotensin Level May Predict Breast Cancer in Women appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Karla M. Gonye, MBA. (2015) Elevated Neurotensin Level May Predict Breast Cancer in Women. MedicalResearch.com. info:/
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.