Evolution reveals why the human body deteriorates with age... Read more »
Jungers, W. (1988) Relative joint size and hominoid locomotor adaptations with implications for the evolution of hominid bipedalism. Journal of Human Evolution, 17(1-2), 247-265. DOI: 10.1016/0047-2484(88)90056-5
Jurmain R. (2000) Degenerative joint disease in African great apes: an evolutionary perspective. Journal of human evolution, 39(2), 185-203. PMID: 10968928
Ward, C. (2002) Interpreting the posture and locomotion ofAustralopithecus afarensis: Where do we stand?. American Journal of Physical Anthropology, 119(S35), 185-215. DOI: 10.1002/ajpa.10185
A small magnetic device might transform breast cancer surgeries... Read more »
Rahusen, F., Bremers, A., Fabry, H., Taets van Amerongen, A., Boom, R., & Meijer, S. (2002) Ultrasound-guided lumpectomy of nonpalpable breast cancer versus wire-guided resection: A randomized clinical trial. Annals of Surgical Oncology, 9(10), 994-998. DOI: 10.1007/BF02574518
Anderson, R., Kimmick, G., McCoy, T., Hopkins, J., Levine, E., Miller, G., Ribisl, P., & Mihalko, S. (2011) A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial. Journal of Cancer Survivorship, 6(2), 172-181. DOI: 10.1007/s11764-011-0208-4
Medina-Franco, H., Abarca-Pérez, L., García-Alvarez, M., Ulloa-Gómez, J., Romero-Trejo, C., & Sepúlveda-Méndez, J. (2008) Radioguided occult lesion localization (ROLL) versus wire-guided lumpectomy for non-palpable breast lesions: A randomized prospective evaluation. Journal of Surgical Oncology, 97(2), 108-111. DOI: 10.1002/jso.20880
Lovrics, P., Cornacchi, S., Vora, R., Goldsmith, C., & Kahnamoui, K. (2011) Systematic review of radioguided surgery for non-palpable breast cancer. European Journal of Surgical Oncology (EJSO), 37(5), 388-397. DOI: 10.1016/j.ejso.2011.01.018
Postma, E., Koffijberg, H., Verkooijen, H., Witkamp, A., van den Bosch, M., & van Hillegersberg, R. (2013) Cost-Effectiveness of Radioguided Occult Lesion Localization (ROLL) Versus Wire-Guided Localization (WGL) in Breast Conserving Surgery for Nonpalpable Breast Cancer: Results from a Randomized Controlled Multicenter Trial. Annals of Surgical Oncology, 20(7), 2219-2226. DOI: 10.1245/s10434-013-2888-7
Ahmed, M., & Douek, M. (2013) A systematic review and meta-analysis of intra-operative ultrasound versus wire-guided localization in the surgical management of non-palpable breast cancers. European Journal of Surgical Oncology (EJSO), 39(11). DOI: 10.1016/j.ejso.2013.07.212
When we think of crime scene forensics, it’s easy to view it as the objective end of criminal investigation. Witnesses waffle, suspects slide around from the truth, and jurors can be misled by emotive evidence. but the physical evidence simply is what it is. Yet forensic work requires human judgment, and opens the door for human error: for example, a tendency to evaluate evidence differently depending on background information. Now a new study in Law and Human Behaviour suggests that investiga........ Read more »
Smalarz, L., Madon, S., Yang, Y., Guyll, M., & Buck, S. (2016) The Perfect Match: Do Criminal Stereotypes Bias Forensic Evidence Analysis?. Law and Human Behavior. DOI: 10.1037/lhb0000190
We've seen that live Borrelia burgdorferi persists (in unculturable form) when infected mice are treated with antibiotics. What we don't know is whether they persist in humans with post-treatment Lyme disease syndrome (PTLDS), which refers to the lingering long-term symptoms experienced by a minority of Lyme disease patients who have been treated with the standard course of antibiotics.In theory, one could simply determine whether B. burgdorferi can be detected in bits of tissue or blood e........ Read more »
Marques A, Telford SR 3rd, Turk SP, Chung E, Williams C, Dardick K, Krause PJ, Brandeburg C, Crowder CD, Carolan HE.... (2014) Xenodiagnosis to detect Borrelia burgdorferi infection: a first-in-human study. Clinical Infectious Diseases, 58(7), 937-45. PMID: 24523212
Bockenstedt LK, & Radolf JD. (2014) Xenodiagnosis for posttreatment Lyme disease syndrome: resolving the conundrum or adding to it?. Clinical Infectious Diseases, 58(7), 946-8. PMID: 24523213
"Children with ADHD [attention-deficit hyperactivity disorder] and ASD [autism spectrum disorder] had low levels of EPA [eicosapentaenoic acid], DHA [docosahexaenoic acid] and AA [arachidonic acid] and high ratio of n-6/n-3 PUFAs [polyunsaturated fatty acid] and these correlated significantly with symptoms. Future research should further investigate abnormal fatty acid metabolism in these disorders."So said the research publication by Natalie Par........ Read more »
Parletta N, Niyonsenga T, & Duff J. (2016) Omega-3 and Omega-6 Polyunsaturated Fatty Acid Levels and Correlations with Symptoms in Children with Attention Deficit Hyperactivity Disorder, Autistic Spectrum Disorder and Typically Developing Controls. PloS one, 11(5). PMID: 27232999
The May entry of "This Month in Blastocystis Research" focusses especially on the increasing interest in Blastocystis in a gut microbiota context. ... Read more »
Audebert C, Even G, Cian A, Blastocystis Investigation Group, Loywick A, Merlin S, Viscogliosi E, & Chabé M. (2016) Colonization with the enteric protozoa Blastocystis is associated with increased diversity of human gut bacterial microbiota. Scientific reports, 25255. PMID: 27147260
Andersen LO, Bonde I, Nielsen HB, & Stensvold CR. (2015) A retrospective metagenomics approach to studying Blastocystis. FEMS microbiology ecology, 91(7). PMID: 26130823
O'Brien Andersen L, Karim AB, Roager HM, Vigsnæs LK, Krogfelt KA, Licht TR, & Stensvold CR. (2016) Associations between common intestinal parasites and bacteria in humans as revealed by qPCR. European journal of clinical microbiology . PMID: 27230509
Ramírez JD, Sánchez A, Hernández C, Flórez C, Bernal MC, Giraldo JC, Reyes P, López MC, García L, Cooper PJ.... (2016) Geographic distribution of human Blastocystis subtypes in South America. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 32-5. PMID: 27034056
The antibiotic arms race is on, while we are rushing to find new antibiotics, bacteria are working on finding ways around them. With that in mind, a new experimental antibiotic developed by a team of scientists successfully treats the deadly MRSA infection and restores the efficacy of a commonly prescribed antibiotic that has become ineffective against MRSA.
... Read more »
Kaul M, Mark L, Zhang Y, Parhi AK, Lyu YL, Pawlak J, Saravolatz S, Saravolatz LD, Weinstein MP, LaVoie EJ.... (2015) TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 59(8), 4845-55. PMID: 26033735
Quality is an ill-defined concept with regard to scholarly literature. Some aspects of quality can be assessed reasonably objectively, and immediately, such as the quality of presentation. But some cannot be readily determined, and need time and ‘digestion’ by the scholarly community, such as the scientific quality of an article. And then there is the quality of a journal’s service to authors, of particular importance for open access publishing that is supported by Article Processing Charg........ Read more »
This post describes what Autoimmune diseases are. Part II will describe the potential of anti-cancer therapies as treatments for Autoimmune disease.... Read more »
Remember Walter Mitty? He was a fictional character who escaped his dull day-to-day existence by constructing elaborate daydreams wherein he was the hero rather than a wallflower. Well, apparently Walter was not so unusual. There are people who spend as much as 60% of their time lost in daydreams. These are people who realize their […]
Can you trust the results of forensic evaluations on legal sanity?
Legal decisions that tick jurors off
Will your genetic defense for that........ Read more »
Bigelsen J, Lehrfeld JM, Jopp DS, & Somer E. (2016) Maladaptive daydreaming: Evidence for an under-researched mental health disorder. Consciousness and Cognition, 254-66. PMID: 27082138
Given my own research interest in the use of specific dietary modifications as possible intervention tools for some aspects of some autism (see here) I was more than interested to read the results published by Faezeh Ghalichi and colleagues  following their randomised-controlled trial of a gluten-free diet (GFD) including some 80 children diagnosed with an autism spectrum disorder (ASD).As part of an area of much discussion, debate and also heated argument down the years, the author........ Read more »
Ghalichi F, Ghaemmaghami J, Malek A, & Ostadrahimi A. (2016) Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial. World journal of pediatrics : WJP. PMID: 27286693
Human skin emits light (albeit the glow is extremely weak) and a wide variety of small molecules that may be sometimes "sniffed" by dogs or even other humans. These chemicals tell a story about our health and wellness, things we eat and drink, touch and breathe. Mosquitoes use such emissions to assess our "attractiveness" from indicators such as Indoles (unpleasantly smelling but healthy "inner soil" biomarker) or carbon dioxide (amount of which correlates with the size of the person........ Read more »
Andreoni G, Standoli CE, & Perego P. (2016) Defining Requirements and Related Methods for Designing Sensorized Garments. Sensors (Basel, Switzerland), 16(6). PMID: 27240361
Gao W, Emaminejad S, Nyein HY, Challa S, Chen K, Peck A, Fahad HM, Ota H, Shiraki H, Kiriya D.... (2016) Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature, 529(7587), 509-14. PMID: 26819044
Imani S, Bandodkar AJ, Mohan AM, Kumar R, Yu S, Wang J, & Mercier PP. (2016) A wearable chemical-electrophysiological hybrid biosensing system for real-time health and fitness monitoring. Nature communications, 11650. PMID: 27212140
Lee H, Choi TK, Lee YB, Cho HR, Ghaffari R, Wang L, Choi HJ, Chung TD, Lu N, Hyeon T.... (2016) A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy. Nature nanotechnology, 11(6), 566-72. PMID: 26999482
Panneer Selvam A, Muthukumar S, Kamakoti V, & Prasad S. (2016) A wearable biochemical sensor for monitoring alcohol consumption lifestyle through Ethyl glucuronide (EtG) detection in human sweat. Scientific reports, 23111. PMID: 26996103
Is copper deficiency contributing to the obesity epidemic? Though small amounts of copper are essential to health - oysters, liver, beans and nuts are good sources - copper's role in metabolism has been unclear: Some studies found that it boosted fat burning, others that it depressed it.
... Read more »
I discuss an upcoming article on how natural selection and sexual selection affect the courtship behavior of the common chameleon.... Read more »
Keren-Rotem, T., Levy, N., Wolf, L., Bouskila, A., & Geffen, E. (2016) Male preference for sexual signalling over crypsis is associated with alternative mating tactics. Animal Behaviour, 43-49. info:/http://dx.doi.org/10.1016/j.anbehav.2016.04.021
"The brain is a three dimensional object." It would seem that this is one of the least controversial facts about the brain, something we can all agree on. But now, in a curious new paper, researchers Arturo Tozzi and James F. Peters suggest that the brain might have an extra dimension: Towards a fourth spatial dimension of brain activity
From topology, a strong concept comes into play in understanding brain functions, namely, the 4D space of a ‘‘hypersphere’s torus’’, undetectable by........ Read more »
Tozzi A, & Peters JF. (2016) Towards a fourth spatial dimension of brain activity. Cognitive neurodynamics, 10(3), 189-99. PMID: 27275375
I don't want to keep you today. Just long enough to draw your attention to the paper by Jones and colleagues  regarding "ongoing efforts toward identification of early biological markers specific to subphenotypes of ASD [autism spectrum disorder]."The potential biomarkers in question this time around were the cytokines/chemokines - those various signalling molecules that seem to have more than a few connections to important processes like inflammation - and how their profile ("mid-gestat........ Read more »
Jones KL, Croen LA, Yoshida CK, Heuer L, Hansen R, Zerbo O, DeLorenze GN, Kharrazi M, Yolken R, Ashwood P.... (2016) Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation. Molecular psychiatry. PMID: 27217154
Scientists have developed a powerful tool for exploring and determining the inherent biological differences between individuals, which overcomes a major hurdle for personalized medicine.
... Read more »
Rapport between a client and therapist is important for therapy to be successful, and part of that is agreeing about the aims of the exercise. You’d think this would include the therapist and client agreeing about the specific nature of the client’s psychological problems. In fact, a new study in Psychotherapy Research finds disagreement isn't harmful to therapy and can even be beneficial.Rolf Holmqvist and his colleagues recruited 846 therapy clients as they started a course of therapy at a........ Read more »
Holmqvist, R., Philips, B., & Mellor-Clark, J. (2015) Client and therapist agreement about the client's problems—Associations with treatment alliance and outcome. Psychotherapy Research, 26(4), 399-409. DOI: 10.1080/10503307.2015.1013160
Yellow haemorraghic fever (YF) is caused by Yellow Fever Virus (YFV), a prototype Flavivirus and as such as related to Japanese Encephalitis Virus (JEV), Dengue Virus (DENV) and Zika Virus (ZIKV). Similar to DENV and ZIKV, YFV is transmitted by Aedes agypti both in Africa and South America and clinical manifestations range from asymptomatic infections to multi organ failure and subsequent death.Here the current outbreak in Angola is discussed. ... Read more »
Wasserman S, Tambyah PA, & Lim PL. (2016) Yellow fever cases in Asia: primed for an epidemic. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. PMID: 27156836
Barrett AD. (2016) Yellow Fever in Angola and Beyond - The Problem of Vaccine Supply and Demand. The New England journal of medicine. PMID: 27276108
Amanna IJ, & Slifka MK. (2016) Questions regarding the safety and duration of immunity following live yellow fever vaccination. Expert review of vaccines. PMID: 27267203
Tilak R, Ray S, Tilak VW, & Mukherji S. (2016) Dengue, chikungunya … and the missing entity - Zika fever: A new emerging threat. Medical journal, Armed Forces India, 72(2), 157-63. PMID: 27257326
Carrington CV, & Auguste AJ. (2013) Evolutionary and ecological factors underlying the tempo and distribution of yellow fever virus activity. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 198-210. PMID: 22981999
Cathey, J., & Marr, J. (2014) Yellow fever, Asia and the East African slave trade. Transactions of the Royal Society of Tropical Medicine and Hygiene, 108(8), 519-519. DOI: 10.1093/trstmh/tru081
Bryant, J., Holmes, E., & Barrett, A. (2007) Out of Africa: A Molecular Perspective on the Introduction of Yellow Fever Virus into the Americas. PLoS Pathogens, 3(5). DOI: 10.1371/journal.ppat.0030075
Tabachnick, W. (1991) Evolutionary Genetics and Arthropod-borne Disease: The Yellow Fever Mosquito. American Entomologist, 37(1), 14-26. DOI: 10.1093/ae/37.1.14
Theiler M, & Anderson CR. (1975) The relative resistance of dengue-immune monkeys to yellow fever virus. The American journal of tropical medicine and hygiene, 24(1), 115-7. PMID: 1111351
Agampodi, S., & Wickramage, K. (2013) Is There a Risk of Yellow Fever Virus Transmission in South Asian Countries with Hyperendemic Dengue?. BioMed Research International, 1-9. DOI: 10.1155/2013/905043
Xiao SY, Guzman H, da Rosa AP, Zhu HB, & Tesh RB. (2003) Alteration of clinical outcome and histopathology of yellow fever virus infection in a hamster model by previous infection with heterologous flaviviruses. The American journal of tropical medicine and hygiene, 68(6), 695-703. PMID: 12887029
"Not tonight, honey," says the female burying beetle, chewing up a mouthful of mouse carcass before spitting it into the mouth of a begging larva.
For the first few days of their babies' lives, burying beetles co-parent. They devote themselves to keeping their squirming larvae alive. That means mating and laying more eggs would be a waste of energy. And to make sure males get that message, females emit a pheromone that turns them off.
"It is quite surprising," says University of Ulm be... Read more »
Engel KC, Stökl J, Schweizer R, Vogel H, Ayasse M, Ruther J, & Steiger S. (2016) A hormone-related female anti-aphrodisiac signals temporary infertility and causes sexual abstinence to synchronize parental care. Nature communications, 11035. PMID: 27002429
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