A method to look at chromosome structure in single cells reveals what the X chromosomes looks like and how it varies from cell to cell.... Read more »
Nagano T, Lubling Y, Stevens TJ, Schoenfelder S, Yaffe E, Dean W, Laue ED, Tanay A, & Fraser P. (2013) Single-cell Hi-C reveals cell-to-cell variability in chromosome structure. Nature, 502(7469), 59-64. PMID: 24067610
This study found no difference in body fat percentage between those with disordered eating and those without. However, sports that emphasized leanness (such as swimming) had higher scores on disordered eating inventories than athletes in sports with weight classes. There was a relationship between male athletes with higher levels of body fat and body image dissatisfaction.
... Read more »
Goltz FR, Stenzel LM, & Schneider CD. (2013) Disordered eating behaviors and body image in male athletes. Revista Brasileira de Psiquiatria (Sao Paulo, Brazil : 1999), 35(3), 237-42. PMID: 24142083
Researchers have found that the cells of the depressed people age rapidly i.e. they grow rapidly than the cells in normal people.
Telomeres are the cell structures that are present at the ends of chromosomes to protect the DNA from any damage. These structures get shortened with time as the cell divides showing the signs of aging.
In the present study, researchers compared the length o........ Read more »
J E Verhoeven, D Révész, E S Epel, J Lin, O M Wolkowitz, B W J H Penninx. (2013) Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. Molecular Psychiatry. DOI: 10.1038/mp.2013.151
Researchers at the New York Stem Cell Foundation (NYSCF) Research Institute and Columbia University Medical Center (CUMC) have used induced pluripotent stem cells created from the skin of patients with a rare form of diabetes (Wolfram syndrome) to elucidate an important biochemical pathway for beta-cell failure in diabetes.During the study, the NYSCF team first produced induced pluripotent stem (iPCs) cells from skin samples from individuals with Wolfram syndrome. They then derived insulin-produ........ Read more »
Linshan Shang, Haiqing Hua, Kylie Foo, Hector Martinez, Kazuhisa Watanabe, Matthew Zimmer, David J Kahler, Matthew Freeby, Wendy Chung, Charles Leduc, Robin Goland, Rudolph L. Leibel, and Dieter Egli. (2013) Beta cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes. info:/
Is the ability to empathize uniquely human? This question has long been pondered by philosophers and animal behaviorists alike. Empathy depends in part on the ability to recognize the wants and hopes of others. A new study by researchers at the University of Cambridge suggests that we may not be alone with this ability. A male Eurasian jay feeds his female mate. Photo provided by Ljerka Ostojić.Ljerka Ostojić, Rachael Shaw, Lucy Cheke, and Nicky Clayton conducted a series of studies on Eurasia........ Read more »
Ostojić, L., Shaw, R.C., Cheke, L.G., & Clayton, N.S. (2013) Evidence suggesting that desire-state attribution may govern food sharing in Eurasian jays. PNAS, 110(10), 4123-4128. DOI: 10.1073/pnas.1209926110
Telomere Depression and Aging If you read the news you may have noticed articles on depression and telomere length. There is no reason to think you are screwed and getThe post Telomeres may shorten with depression but there are things you can do to protect them. appeared first on WODMasters.... Read more »
Phillips AC, Robertson T, Carroll D, Der G, Shiels PG, McGlynn L, & Benzeval M. (2013) Do symptoms of depression predict telomere length? Evidence from the west of Scotland twenty-07 study. Psychosomatic medicine, 75(3), 288-96. PMID: 23513237
Boccardi V, Esposito A, Rizzo MR, Marfella R, Barbieri M, & Paolisso G. (2013) Mediterranean diet, telomere maintenance and health status among elderly. PloS one, 8(4). PMID: 23646142
Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, Marlin R, Frenda SJ, Magbanua MJ, Daubenmier J.... (2013) Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. The lancet oncology, 14(11), 1112-20. PMID: 24051140
Kim JH, Ko JH, Lee DC, Lim I, & Bang H. (2012) Habitual physical exercise has beneficial effects on telomere length in postmenopausal women. Menopause (New York, N.Y.), 19(10), 1109-15. PMID: 22668817
by sschroeder in Daily Observations
Many of us might remember our parents insisting that we get a good night’s sleep before a big exam or test, with the argument that being well rested would help […]... Read more »
Deliens, G., Gilson, M., Schmitz, R., . (2013) Sleep unbinds memories from their emotional context. Cortex, 49(8), 2221-2228. DOI: 10.1016/j.cortex.2012.11.014
Methane hydrates are a potential energy source—only the already known methane hydrate reservoirs in the U.S. are expected to contain 6,700 trillion cubic feet of natural gas—more than the largest conventional natural gas fields. They, however, are also a potential source of global warming if massive amounts of methane were released during an earthquake or by rising ocean temperatures. A pair of methane-eating microbes may play a key role in this process.... Read more »
Glass J.B., Yu H., Steele J.A., Dawson K.S., Sun S., Chourey K., Pan C., Hettich R.L., & Orphan V.J. (2013) Geochemical, metagenomic and metaproteomic insights into trace metal utilization by methane-oxidizing microbial consortia in sulfidic marine sediments. Environmental Microbiology. PMID: 24148160
This is the second in a series of three posts examining the role of preterm birth in later child and adult brain disorders.In a previous post, I reviewed a recent study showing evidence on increased risk for anxiety disorder, ADHD and autism in preterm birth children by age 7 years of age.In this post I want to review and comment on a large French study of outcome in a cohort of very preterm children.Marrett and colleagues summarized the key elements in the design of their research:Sample: All p........ Read more »
Marret S, Marchand-Martin L, Picaud JC, Hascoët JM, Arnaud C, Rozé JC, Truffert P, Larroque B, Kaminski M, Ancel PY.... (2013) Brain injury in very preterm children and neurosensory and cognitive disabilities during childhood: the EPIPAGE cohort study. PloS one, 8(5). PMID: 23658763
PhD student Kirk Kristofferson acknowledged that each “Like” or “Share” push us further away from meaningful support. For each of these actions, most people feel that their mission is “accomplished”. “Our research shows that if people are able to declare support for a charity publicly in social media it can actually make them less likely to donate to the cause later on.” Kristofferson reinforces.... Read more »
Saxton, Gregory D. and Wang, Lili,. (2013) The Social Network Effect: The Determinants of Giving through Social Media . Nonprofit and Voluntary Sector Quarterly. DOI: 10.1177/0899764013485159
Researchers have found that nostalgic feelings (about the past) can help in increasing positivity about the future.
Personality and Social Psychology Bulletin
It is a mixed feeling of happiness, sadness, and longing when recalling a person, place, or event from the past, or the past in general.
“Nostalgia is experienced frequently and virtually by everyone and we know that it can maintain psychological comfort. For ex........ Read more »
Welcome to Part 2 of my journey to the movie theater. This will make sense if you haven’t read Part 1, but to enjoy the full impact of this visite du cinéma, I suggest you read both. If ya just don’t wanna then here’s a summary: (1) movie tickets are expensive, (2) as far as I can tell, nobody has really done a direct study of why, (3) economists try to explain why all movies cost the same through their “uniform pricing for differentiated goods” theory, (4) as it turns out, variable o........ Read more »
B. Wansink, & S.B. Park. (2001) At the movies: how external cues and perceived taste impact consumption volume. Food Quality and Preference, 69-74. DOI: 10.1016/S0950-3293(00)00031-8
B. Wansink, & J. Kim. (2005) Bad Popcorn in Big Buckets: Portion Size Can Influence Intake as Much as Taste. Journal of Nutrition Education and Behavior, 37(5), 242-245. DOI: 10.1016/S1499-4046(06)60278-9
D. Marchiori, O. Corneille, & O. Klein. (2012) Container size influences snack food intake independently of portion size. Appetite, 814-817. DOI: 10.1016/j.appet.2012.01.015
S. Topolinski, S. Lindner, & A. Freudenberg. (2013) Popcorn in the cinema: Oral interference sabotages advertising effects. Journal of Consumer Psychology. DOI: 10.1016/j.jcps.2013.09.008
Recently we announced our newest training materials on GenoCAD. The introductory tutorial provides a great foundation for understanding the features that are available and how it could help you in the lab. But for those folks who want to take their design skills further–now you can use the GenoCAD Advanced Topics materials to do so. […]... Read more »
Wilson ML., Hertzberg R., Adam L., & Peccoud J. (2011) A step-by-step introduction to rule-based design of synthetic genetic constructs using GenoCAD. Methods Enzymol. DOI: 10.1016/B978-0-12-385120-8.00008-5
Wilson M. L., Okumoto S., Adam L., & Peccoud J. (2013) Development of a domain-specific genetic language to design Chlamydomonas reinhardtii expression vectors. Bioinformatics. DOI: 10.1093/bioinformatics/btt646
In evolutionary theory, a fitness landscape is a map where fitness is a function of either the genotype or the phenotype. The genotype is some description of the genetic make-up of an organism. This can be the DNA or a list of the mutations/alleles, and are discrete variables. ... Read more »
Jasper Franke, Alexander Klözer, J. Arjan G. M. de Visser, & Joachim Krug. (2011) Evolutionary accessibility of mutational pathways. PLoS Computational Biology 7 (8) e1002134 (2011). arXiv: 1103.2479v2
Weissman DB, Desai MM, Fisher DS, & Feldman MW. (2009) The rate at which asexual populations cross fitness valleys. Theoretical population biology, 75(4), 286-300. PMID: 19285994
Østman B, Hintze A, & Adami C. (2012) Impact of epistasis and pleiotropy on evolutionary adaptation. Proceedings. Biological sciences / The Royal Society, 279(1727), 247-56. PMID: 21697174
Basic social skills of African elephants remain impaired decades after surviving devastating experiences. ... Read more »
Shannon G, Slotow R, Durant SM, Sayialel KN, Poole J, Moss C, & McComb K. (2013) Effects of social disruption in elephants persist decades after culling. Frontiers in Zoology, 62. PMID: 24152378
You can hardly turn on the television or radio these days and not hear a discussion about rising gas prices. When most people set out to buy a new car it’s no doubt that fuel efficiency is one of the … Continue reading →... Read more »
Doebbe Anja, Rupprecht Jens, Beckmann Julia, Mussgnug Jan H., Hallmann Armin, Hankamer Ben, & Kruse Olaf. (2007) Functional integration of the HUP1 hexose symporter gene into the genome of C. reinhardtii: Impacts on biological H2 production. Journal of Biotechnology, 131(1), 27-33. DOI: 10.1016/j.jbiotec.2007.05.017
Kruse O. (2005) Improved Photobiological H2 Production in Engineered Green Algal Cells. Journal of Biological Chemistry, 280(40), 34170-34177. DOI: 10.1074/jbc.M503840200
Hankamer Ben, Lehr Florian, Rupprecht Jens, Mussgnug Jan H., Posten Clemens, & Kruse Olaf. (2007) Photosynthetic biomass and H production by green algae: from bioengineering to bioreactor scale-up . Physiologia Plantarum, 131(1), 10-21. DOI: 10.1111/j.1399-3054.2007.00924.x
In the process of domestication, it seems that dogs have become especially attuned to human communication. Does this mean they can cooperate with a human to solve a problem? And what if they need to cooperate with another dog instead? A study in press by Ostojić and Clayton investigates.Photo: Jim Parkin / ShutterstockThe study is based on a “string task” in which two dogs (or a dog and a human) have to pull each end of a string in order to gain access to food that is otherwise out........ Read more »
Ostojic, L, & Clayton, N.S. (2013) Behavioural coordination of dogs in a cooperative problem-solving task with a conspecific and a human partner. Animal Cognition. DOI: 10.1007/s10071-013-0676-1
We are taught and we teach that DNA codes fro the amino acid sequence of specific proteins. But the truth is that often times, the sequence of the mRNA ends of different than that coded by the DNA. In addition to mRNA processing, there is also RNA editing, which can add, subtract, or change the base sequence in a transcript.
New research is showing just how extensive RNA editing is and the powerful role it plays in cellular expression. A new algorithm has been introduced to better predict R........ Read more »
Paz-Yaacov N, Levanon EY, Nevo E, Kinar Y, Harmelin A, Jacob-Hirsch J, Amariglio N, Eisenberg E, & Rechavi G. (2010) Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates. Proceedings of the National Academy of Sciences of the United States of America, 107(27), 12174-9. PMID: 20566853
Takahashi T, Otsuguro K, Ohta T, & Ito S. (2010) Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats. British journal of pharmacology, 161(8), 1806-16. PMID: 20735412
Lenz H, & Knoop V. (2013) PREPACT 2.0: Predicting C-to-U and U-to-C RNA Editing in Organelle Genome Sequences with Multiple References and Curated RNA Editing Annotation. Bioinformatics and biology insights, 1-19. PMID: 23362369
Poulsen HE, Nadal LL, Broedbaek K, Nielsen PE, & Weimann A. (2013) Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid. Biochimica et biophysica acta. PMID: 23791936
Wang P, Fisher D, Rao A, & Giese RW. (2012) Nontargeted nucleotide analysis based on benzoylhistamine labeling-MALDI-TOF/TOF-MS: discovery of putative 6-oxo-thymine in DNA. Analytical chemistry, 84(8), 3811-9. PMID: 22409256
by amikulak in Daily Observations
In order to be able to make sound health decisions, patients need to understand the risks and the benefits that come with medical treatments, screenings, and lifestyle choices. But many […]... Read more »
The southern beeches used to classified in one genus (Nothofagus) and one family (Nothofagaceae). A new paper argues convincingly that the genus should be divided into four genera.... Read more »
Heenan, P.B.; Smissen, R.D. (2013) Revised circumscription of Nothofagus and recognition of the segregate genera Fuscospora, Lophozonia, and Trisyngyne (Nothofagaceae). Phytotaxa. DOI: 10.11646/phytotaxa.146.1.1
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