Neurological disorders typically involve memory issues. Most of the problems are attributed to plaques that build up in the brain (which are typically prions), yet some causes are unknown. New research however sheds some light on at least one cause of memory problems. As it turns out brain inflammation can rapidly disrupt our ability to retrieve complex memories of similar but distinct experiences.... Read more »
Czerniawski J, & Guzowski JF. (2014) Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(37), 12470-80. PMID: 25209285
"Overall, the present findings suggest that metabolic and hormonal disturbances such as effects on insulin and growth hormone may represent a vulnerability factor to develop mental disorders". That was the conclusion reported by van Beveren and colleagues  (open-access) looking at "disruption of insulin and growth factor signaling pathways as an increased risk factor for schizophrenia"."Years ago you served my father in the Clone Wars"Drawing on data derived from participants taking part in&n........ Read more »
van Beveren NJ, Schwarz E, Noll R, Guest PC, Meijer C, de Haan L, & Bahn S. (2014) Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia. Translational psychiatry. PMID: 25158005
Completed Scrabble (left) and crossword grids (image from Toma et al 2014).Every year, hundreds of word lovers arrive from across the US to compete in the American Crossword Puzzle tournament. They solve clues (e.g. "caught some Z's") and place the answers (e.g. "sleep") in a grid. Meanwhile, a separate group of wordsmiths gather regularly to compete at Scrabble, the game that involves forming words out of letter tiles and finding a suitable place for them on the board.Both sets of players have ........ Read more »
Toma, M., Halpern, D., & Berger, D. (2014) Cognitive Abilities of Elite Nationally Ranked SCRABBLE and Crossword Experts. Applied Cognitive Psychology. DOI: 10.1002/acp.3059
Get caught up quick on the hottest science news from this week!... Read more »
Denoeud, F., Carretero-Paulet, L., Dereeper, A., Droc, G., Guyot, R., Pietrella, M., Zheng, C., Alberti, A., Anthony, F., Aprea, G.... (2014) The coffee genome provides insight into the convergent evolution of caffeine biosynthesis. Science, 345(6201), 1181-1184. DOI: 10.1126/science.1255274
Long, C., McAnally, J., Shelton, J., Mireault, A., Bassel-Duby, R., & Olson, E. (2014) Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science, 345(6201), 1184-1188. DOI: 10.1126/science.1254445
Scientists have opened a new window in science by finding that an effective magnetic field can exist for light.
Magnetic field refers to the line of forces that are present around the permanent magnet or a moving charged particle. This field can change the path of charged particles such as electrons. Usually, magnetic field has no effect on neutral particles such as photons, which are present in light. However, the present stu........ Read more »
Tzuang, L., Fang, K., Nussenzveig, P., Fan, S., & Lipson, M. (2014) Non-reciprocal phase shift induced by an effective magnetic flux for light. Nature Photonics, 8(9), 701-705. DOI: 10.1038/nphoton.2014.177
A cancer survivor is defined as anyone who is living with cancer, or whose cancer has gone into remission. Traditionally cancer care has concentrated on diagnosing and treating the disease, and comparatively little support has been given to patients once … Continue reading →... Read more »
Moretto P, Jewett MA, Basiuk J, Maskens D, & Canil CM. (2014) Kidney cancer survivorship survey of urologists and survivors: The gap in perceptions of care, but agreement on needs. Canadian Urological Association journal , 8(5-6), 190-4. PMID: 25024789
The study of the brain has been very neuron centered. Glial cells outnumber neuron by about 10 to 1 in the cortex and are known to be important to brain function but it is not clear just what they do other than some housekeeping tasks and shepherding neurons to their final locations during development. Astrocyte […]... Read more »
Lee, H., Ghetti, A., Pinto-Duarte, A., Wang, X., Dziewczapolski, G., Galimi, F., Huitron-Resendiz, S., Pina-Crespo, J., Roberts, A., Verma, I.... (2014) Astrocytes contribute to gamma oscillations and recognition memory. Proceedings of the National Academy of Sciences, 111(32). DOI: 10.1073/pnas.1410893111
One of the exciting things in reading philosophy, its history in particular, is experiencing the tension between different schools of thought. This excitement turns to beauty if a clear synthesis emerges to reconcile the conflicting ideas. In the middle to late 18th century, as the Age of Enlightenment was giving way to the Romantic era, […]... Read more »
Post, E.L. (1936) Finite combinatory processes -- formulation 1. Journal of Symbolic Logic, 1(3), 103-105. info:/
"Barefoot Running and Hip Kinematics: Good News for the Knee?"; what about "Bad News for the Ankle"?... Read more »
McCarthy C, Fleming N, Donne B, & Blanksby B. (2014) Barefoot Running and Hip Kinematics: Good News for the Knee?. Medicine and science in sports and exercise. PMID: 25207927
As your therapist likely tells you, understanding where you came from is key to accepting where you are now. Take that therapist’s task and multiply it by several million—you now understand the tough job ahead of developmental biologists trying to track cell lineages in complex organisms. Today’s colorful image is from a paper describing a new computational framework for reconstructing cell lineages. The successful tracking of cell position, division, and movement in a developing or........ Read more »
Amat, F., Lemon, W., Mossing, D., McDole, K., Wan, Y., Branson, K., Myers, E., & Keller, P. (2014) Fast, accurate reconstruction of cell lineages from large-scale fluorescence microscopy data. Nature Methods, 11(9), 951-958. DOI: 10.1038/nmeth.3036
Whilst the nature of the RTC and the role of the CoV non-structural proteins as well the potential role of these proteins in the ER stress response have been discussed in detail before, the role of p6 has been not been discussed. p6 not only induces the formation of membranous vesicles but also recruits nsp-8 to nsp-5, the main viral RNA Polymerase, and induces a ER stress response.
Also the role of SARS-orf9b in the induction of mitophagy is discussed.... Read more »
Zhong Y, Tan YW, & Liu DX. (2012) Recent progress in studies of arterivirus- and coronavirus-host interactions. Viruses, 4(6), 980-1010. PMID: 22816036
Shi CS, Qi HY, Boularan C, Huang NN, Abu-Asab M, Shelhamer JH, & Kehrl JH. (2014) SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome. Journal of immunology (Baltimore, Md. : 1950), 193(6), 3080-9. PMID: 25135833
Tangudu C, Olivares H, Netland J, Perlman S, & Gallagher T. (2007) Severe acute respiratory syndrome coronavirus protein 6 accelerates murine coronavirus infections. Journal of virology, 81(3), 1220-9. PMID: 17108045
Hussain S, & Gallagher T. (2010) SARS-coronavirus protein 6 conformations required to impede protein import into the nucleus. Virus research, 153(2), 299-304. PMID: 20800627
Otera H, Ishihara N, & Mihara K. (2013) New insights into the function and regulation of mitochondrial fission. Biochimica et biophysica acta, 1833(5), 1256-68. PMID: 23434681
Kumar P, Gunalan V, Liu B, Chow VT, Druce J, Birch C, Catton M, Fielding BC, Tan YJ, & Lal SK. (2007) The nonstructural protein 8 (nsp8) of the SARS coronavirus interacts with its ORF6 accessory protein. Virology, 366(2), 293-303. PMID: 17532020
Ye Z, Wong CK, Li P, & Xie Y. (2008) A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosis. Biochimica et biophysica acta, 1780(12), 1383-7. PMID: 18708124
Subissi L, Imbert I, Ferron F, Collet A, Coutard B, Decroly E, & Canard B. (2014) SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets. Antiviral research, 122-30. PMID: 24269475
Fung TS, Liao Y, & Liu DX. (2014) The ER stress sensor IRE1α protects cells from apoptosis induced by coronavirus infectious bronchitis virus. Journal of virology. PMID: 25142592
Guo W, Ding J, Zhang A, Dai W, Liu S, Diao Z, Wang L, Han X, & Liu W. (2014) The inhibitory effect of quercetin on asymmetric dimethylarginine-induced apoptosis is mediated by the endoplasmic reticulum stress pathway in glomerular endothelial cells. International journal of molecular sciences, 15(1), 484-503. PMID: 24451129
Cruz JL, Sola I, Becares M, Alberca B, Plana J, Enjuanes L, & Zuñiga S. (2011) Coronavirus gene 7 counteracts host defenses and modulates virus virulence. PLoS pathogens, 7(6). PMID: 21695242
Neuman BW, Angelini MM, & Buchmeier MJ. (2014) Does form meet function in the coronavirus replicative organelle?. Trends in microbiology. PMID: 25037114
Angelini MM, Akhlaghpour M, Neuman BW, & Buchmeier MJ. (2013) Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles. mBio, 4(4). PMID: 23943763
Subissi L, Posthuma CC, Collet A, Zevenhoven-Dobbe JC, Gorbalenya AE, Decroly E, Snijder EJ, Canard B, & Imbert I. (2014) One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities. Proceedings of the National Academy of Sciences of the United States of America. PMID: 25197083
Moshynskyy I, Viswanathan S, Vasilenko N, Lobanov V, Petric M, Babiuk LA, & Zakhartchouk AN. (2007) Intracellular localization of the SARS coronavirus protein 9b: evidence of active export from the nucleus. Virus research, 127(1), 116-21. PMID: 17448558
Anyone who has seen pictures or models of the human brain (like the one above) is aware that the outside layer, or cortex, of the brain is folded in an intricate pattern of “hills”, called gyri, and “valleys”, called sulci which give the brain it’s distinctive look. It turns out that the patterns of cortical folding are largely consistent across healthy humans, broadly speaking. However, disturbances in cortical folding patterns suggest deeper disturbances in brain structure and functi........ Read more »
Nanda P, Tandon N, Mathew IT, Giakoumatos CI, Abhishekh HA, Clementz BA, Pearlson GD, Sweeney J, Tamminga CA, & Keshavan MS. (2014) Local gyrification index in probands with psychotic disorders and their first-degree relatives. Biological psychiatry, 76(6), 447-55. PMID: 24369266
Our sense of where our bodies begin and end usually feels consistent and reliable. However psychologists have been having fun for decades, exposing just how malleable the body concept can be.You may have heard of the "rubber hand illusion" (video). By visibly stroking a rubber hand in time with stroking a participant's hidden real hand, you can induce for them the feeling of sensation in the rubber hand.The rubber hand illusion is thought to occur because the brain tends to bind together informa........ Read more »
I had been waiting y'know. Waiting a while for the paper by Sally Rogers and colleagues  to finally appear quite a few days after the media headlines about 'reducing', 'reversing' and even 'eliminating' the signs and symptoms of autism in early infancy had appeared. Personally, I prefer the New Scientist headline: 'Early autism intervention speeds infant development' given the text of the paper. I should perhaps also add the words 'for some' to that sentence as you will hopefully see...I........ Read more »
S. J. Rogers, L. Vismara, A. L. Wagner, C. McCormick, G. Young, & S. Ozonoff. (2014) Autism Treatment in the First Year of Life: A Pilot Study of Infant Start, a Parent-Implemented Intervention for Symptomatic Infants. Journal of Autism and Developmental Disorders. info:/10.1007/s10803-014-2202-y
You may have seen headlines over the past week proclaiming that handsome men have lower-quality sperm. If this made you panic because you happen to be a great-looking guy, you can stop. (If you’re an un-handsome man who’s been gloating—sorry.) This scientific study did say a few interesting things about Spaniards, Colombians, and cheekbones. But […]The post Stop Worrying, Good-Looking Dudes: Your Sperm Is Fine appeared first on Inkfish.... Read more »
Soler C, Kekäläinen J, Núñez M, Sancho M, Alvarez JG, Núñez J, Yaber I, & Gutiérrez R. (2014) Male facial attractiveness and masculinity may provide sex- and culture-independent cues to semen quality. Journal of evolutionary biology, 27(9), 1930-8. PMID: 25056484
Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here […]... Read more »
Luo Hao, Lin Yan, Gao Feng, Zhang Chun-Ting, & Zhang Ren. (2013) DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements. Nucleic acids research. PMID: 24243843
"These results demonstrate that n-3 PUFAs dietary supplementation, although not a panacea, has a considerable therapeutic value for FXS [Fragile X syndrome] and potentially for ASD [autism spectrum disorder], suggesting a major mediating role of neuroinflammatory mechanisms".A view @ Wikipedia That was the conclusion reached by Susanna Pietropaolo and colleagues  who "evaluated the impact of n-3 PUFA dietary supplementation in a mouse model of fragile X syndrome ........ Read more »
Pietropaolo S, Goubran MG, Joffre C, Aubert A, Lemaire-Mayo V, Crusio WE, & Layé S. (2014) Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice. Psychoneuroendocrinology, 119-129. PMID: 25080404
Patellofemoral Joint Stress during Running with Alterations in Foot Strike Pattern... Read more »
Nathan Vannatta C, & Kernozek TW. (2014) Patellofemoral Joint Stress during Running with Alterations in Foot Strike Pattern. Medicine and science in sports and exercise. PMID: 25202853
We like to give treatments that produce results that we can see and logically attribute to the treatments we gave.
We like to give IV (IntaVenous) furosemide (Lasix – frusemide in Commonwealth countries) for CHF (Congestive Heart Failure).
1. The patient had CHF.
2. I gave IV furosemide.
3. The patient produced urine.... Read more »
Figueras J, & Weil MH. (1978) Blood volume prior to and following treatment of acute cardiogenic pulmonary edema. Circulation, 57(2), 349-55. PMID: 618625
Francis GS, Siegel RM, Goldsmith SR, Olivari MT, Levine TB, & Cohn JN. (1985) Acute vasoconstrictor response to intravenous furosemide in patients with chronic congestive heart failure. Activation of the neurohumoral axis. Annals of internal medicine, 103(1), 1-6. PMID: 2860833
Hoffman JR, & Reynolds S. (1987) Comparison of nitroglycerin, morphine and furosemide in treatment of presumed pre-hospital pulmonary edema. Chest, 92(4), 586-93. PMID: 3115687
Sometimes, the employer is even in a bigger need than the job seeker. And the most used instrument which can bring these two together is a resume.... Read more »
Mark Wilson. (2012) How To Redesign Your Resume For A Recruiter’s 6-Second Attention Span. fastcodesign.com. info:/
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