Well we took a bit of a break these past couple of weeks, but we are back for the new year! Welcome to the Prophage blog 2017! The year has actually been off to a good start, with a lot of interesting papers being published this January. This week I want to kick things off by covering a very cool 2017 study by Erez et al that described an new and interesting mechanism by which bacteriophages communicate using...... Read more »
Erez, Z., Steinberger-Levy, I., Shamir, M., Doron, S., Stokar-Avihail, A., Peleg, Y., Melamed, S., Leavitt, A., Savidor, A., Albeck, S.... (2017) Communication between viruses guides lysis–lysogeny decisions. Nature, 541(7638), 488-493. DOI: 10.1038/nature21049
RCT of traditional running shoes vs minimalist running shoes... Read more »
Fuller, J., Thewlis, D., Buckley, J., Brown, N., Hamill, J., & Tsiros, M. (2017) Body Mass and Weekly Training Distance Influence the Pain and Injuries Experienced by Runners Using Minimalist Shoes. The American Journal of Sports Medicine, 2147483647. DOI: 10.1177/0363546516682497
President Trump this week repeated an assertion he made shortly after his election: that millions of ballots cast illegally by undocumented immigrants cost him the popular vote. If true, this would suggest the wholesale corruption of American democracy.
Not to worry: As far as anyone knows, the president’s assertion is akin to saying that millions of unicorns also voted illegally.
- In a
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Preller, K., Herdener, M., Pokorny, T., Planzer, A., Kraehenmann, R., Stämpfli, P., Liechti, M., Seifritz, E., & Vollenweider, F. (2017) The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation. Current Biology. DOI: 10.1016/j.cub.2016.12.030
Wacker, D., Wang, S., McCorvy, J., Betz, R., Venkatakrishnan, A., Levit, A., Lansu, K., Schools, Z., Che, T., Nichols, D.... (2017) Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell, 168(3), 377-2147483647. DOI: 10.1016/j.cell.2016.12.033
Continuing the theme of blogging outside of the core material typically included on this site, I couldn't resist a mention of the 'head-to-head' debate talked about in the article by Matthew Kurien and colleagues  published in the British Medical Journal (BMJ).As per the title of this post, the name of the game was gluten-free products being available on prescription here in Blighty, and in particular, the prescribing of gluten-free products to patients diagnosed with coeliac disease. Th........ Read more »
Kurien M, Sleet S, Sanders DS, & Cave J. (2017) Should gluten-free foods be available on prescription?. BMJ (Clinical research ed.). PMID: 28073799
When we're feeling very tired, we sometimes remark that we're "half-asleep". But is this more than just a figure of speech? A new paper suggests that parts of our brain may actually 'fall asleep' even while we're still awake.
According to researchers Jeremy D. Slater and colleagues of the University of Texas, "local sleep" occurs throughout the human brain, with each brain region passing into and out of a sleep-like state over time. What's more, local sleep becomes more and more common in... Read more »
Slater JD, Chelaru MI, Hansen BJ, Beaman C, Kalamangalam G, Tandon N, & Dragoi V. (2017) Focal Changes to Human Electrocorticography With Drowsiness: A Novel Measure of Local Sleep. The Journal of Neuropsychiatry and Clinical Neurosciences. PMID: 28121257
uring the current Zika Virus (ZIKV) outbreaks in the Americas, an increased number of cognitive malformations including but not limited to microcephaly in foetuses and neonates of mothers who had been infected with ZIKV during pregnancy, lead to the conclusion that ZIKV might be neuroteratogenic, a hypothesis that has been supported by findings that various ZIKV strains –including isolates from Asia such ZIKV SZ 01, ZIKV FSS13025 and H/PF/2013 as well as isolates from the Americas such as........ Read more »
van den Pol AN, Mao G, Yang Y, Ornaghi S, & Davis JN. (2017) Zika virus targeting in the developing brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. PMID: 28123079
Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell, 19(5), 593-598. PMID: 27545505
Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870
Garcez PP, Nascimento JM, de Vasconcelos JM, Madeiro da Costa R, Delvecchio R, Trindade P, Loiola EC, Higa LM, Cassoli JS, Vitória G.... (2017) Zika virus disrupts molecular fingerprinting of human neurospheres. Scientific reports, 40780. PMID: 28112162
Gabriel, E., Ramani, A., Karow, U., Gottardo, M., Natarajan, K., Gooi, L., Goranci-Buzhala, G., Krut, O., Peters, F., Nikolic, M.... (2017) Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell. DOI: 10.1016/j.stem.2016.12.005
Ghouzzi VE, Bianchi FT, Molineris I, Mounce BC, Berto GE, Rak M, Lebon S, Aubry L, Tocco C, Gai M.... (2017) ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53. Cell death , 8(1). PMID: 28102842
Caldon CE, & Musgrove EA. (2010) Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer. Cell division, 2. PMID: 20180967
Gromley A, Jurczyk A, Sillibourne J, Halilovic E, Mogensen M, Groisman I, Blomberg M, & Doxsey S. (2003) A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. The Journal of cell biology, 161(3), 535-45. PMID: 12732615
Shimada M, Matsuzaki F, Kato A, Kobayashi J, Matsumoto T, & Komatsu K. (2016) Induction of Excess Centrosomes in Neural Progenitor Cells during the Development of Radiation-Induced Microcephaly. PloS one, 11(7). PMID: 27367050
Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK.... (2016) 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. The Journal of cell biology, 214(2), 155-66. PMID: 27432897
Liu H, Gong M, French BA, Liao G, Li J, Tillman B, & French SW. (2015) Aberrant modulation of the BRCA1 and G1/S cell cycle pathways in alcoholic hepatitis patients with Mallory Denk Bodies revealed by RNA sequencing. Oncotarget, 6(40), 42491-503. PMID: 26623723
Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM.... (2016) Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Scientific reports, 39775. PMID: 28008958
But we still don’t recommend it in polite company (aka, the courtroom)! An international team of researchers (from the Netherlands, Hong Kong, the United States and the United Kingdom) have just published an article examining two perspectives on profanity and honesty. The researchers say that, on one hand, profanity is considered a violation of social […]... Read more »
Feldman, G., Lian, H., Kosinski, M., & Stillwell, D. (2017) Frankly, We Do Give a Damn: The relationship between profanity and honesty. Social Psychological and Personality Science, 2147483647. DOI: 10.1177/1948550616681055
VHL genetic alterations do not affect the production of HIF-α in clear-cell renal cell carcinoma (ccRCC). However, their effects on tuberous sclerosis proteins (TSC1/2) and heat shock protein 90 (Hsp90) expression are currently unknown. In a recent study, Damjanovic et al. (2016) evaluated the impact of VHL genetic alterations and HIF-α production on the expression of TSC proteins and Hsp90 in 47 sporadic ccRCCs and corresponding normal tissues.... Read more »
Damjanovic SS, Ilic BB, Beleslin Cokic BB, Antic JA, Bankovic JZ, Milicevic IT, Rodic GS, Ilic DS, Todorovic VN, Puskas N.... (2016) Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1α production in sporadic clear-cell renal cell carcinoma. Experimental and molecular pathology, 101(3), 323-331. PMID: 27845047
by Piter Kehoma Boll Today’s Friday Fellow lives in our houses and our gardens, among our food and our crops. And every time we notice it, we get upset, because it means that something we were supposed to eat is … Continue reading →... Read more »
Hernández-Lauzardo, A., Bautista-Baños, S., Velázquez-del Valle, M., Méndez-Montealvo, M., Sánchez-Rivera, M., & Bello-Pérez, L. (2008) Antifungal effects of chitosan with different molecular weights on in vitro development of Rhizopus stolonifer (Ehrenb.:Fr.) Vuill. Carbohydrate Polymers, 73(4), 541-547. DOI: 10.1016/j.carbpol.2007.12.020
"The results of this systematic review show that low vitamin D levels might contribute to the development of dementia."Whilst slightly off-topic when it comes to the core research material typically included on this blog, I did want to bring to your attention the systematic review and meta-analysis results published by Isolde Sommer and colleagues  (open-access) for your perusal. Although unable to "identify a single study investigating the association between sunlight exposure and demen........ Read more »
Sommer I, Griebler U, Kien C, Auer S, Klerings I, Hammer R, Holzer P, & Gartlehner G. (2017) Vitamin D deficiency as a risk factor for dementia: a systematic review and meta-analysis. BMC geriatrics, 17(1), 16. PMID: 28086755
Researchers at the Federal University of Pelotas (UFPel) in Pelotas, Rio Grande do Sul, Brazil, tested the methods of measuring growth rates of Criollo foals and showed that body height and chest circumference can be assessed by means of nonlinear models simultaneously in males and females. … Read More →... Read more »
Pimentel, A., Rodrigues, W., Martins, C., Montanez, N., Boligon, A., & Souza, J. (2017) Gender on the growth of Criollo foals from birth to three years of age. Ciência Rural, 47(1). DOI: 10.1590/0103-8478cr20150989
An 800-year-old ceremonial complex near the famous cliff dwellings of Mesa Verde was built using the same basic geometry found in ancient monuments from Greece to Egypt, a new study has found.
... Read more »
Sherry Towers. (2016) Advanced geometrical constructs in a Pueblo ceremonial site, c 1200 CE. Journal of Archaeological Science: Reports. arXiv: 1605.09494v2
"This paper provides an overview of the benefits and drawbacks of the current clinical pathway that places primacy on a diagnostic assessment for triggering the commencement of therapy. The paper then presents an alternative clinical pathway - the identification and provision of therapy to infants at risk of ASD [autism spectrum disorder] - and provides a critical review of current evidence supporting this model."So said the 'lecture paper' by Andrew Whitehouse  and, as per the titl........ Read more »
Whitehouse AJ. (2017) Elizabeth Usher Memorial Lecture: Rethinking the clinical pathway for autism spectrum disorder and challenging the status quo. International journal of speech-language pathology, 1-10. PMID: 28084105
Abrupt changes in the biological clock or circadian rhythm are noted to contribute to significant cognitive and psychomotor impairments.One practical area for this effect to potentially be important is in the area of sports performance.Alex Song and colleagues recently completed an interesting study of major league baseball (MLB) performance related to team travel patterns.The major leagues are divided into regional divisions (western, central and eastern) to minimize length of travel to and fro........ Read more »
Song A, Severini T, & Allada R. (2017) How jet lag impairs Major League Baseball performance. Proceedings of the National Academy of Sciences of the United States of America. PMID: 28115724
Horse ‘licking and chewing’: is it a sign of learning, submission or stress?Guest post by Georgina (Gina) Bishopp (Hartpury College, UK). A little while ago I was having a lesson on my horse when my instructor beamed up at me and exclaimed, “There you go, she is licking and chewing – she’s really listening to you now, keep going!” and with excitement I continued on eagerly with the exercise we were practising. It wasn’t until the exhilaration of the moment had waned did I thin........ Read more »
Goodwin, D. (2010) The importance of ethology in understanding the behaviour of the horse. Equine Veterinary Journal, 31(S28), 15-19. DOI: 10.1111/j.2042-3306.1999.tb05150.x
Warren-Smith AK, & McGreevy PD. (2008) Preliminary investigations into the ethological relevance of round-pen (round-yard) training of horses. Journal of applied animal welfare science : JAAWS, 11(3), 285-98. PMID: 18569224
I've talked about 'fecal microbial transplants' a.k.a the poo(p) transplant before on this blog (see here). That previous entry was about the more typical (and potentially life-saving) use of a poo transplant - where stool from one person is extracted, 'repackaged' and transferred to another person - albeit with caveats in terms of possible long-term side-effects. Now it appears that poo transplants are being investigated with something rather more central to the typical cont........ Read more »
Kang, D., Adams, J., Gregory, A., Borody, T., Chittick, L., Fasano, A., Khoruts, A., Geis, E., Maldonado, J., McDonough-Means, S.... (2017) Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome, 5(1). DOI: 10.1186/s40168-016-0225-7
Epigenetic regulation is thought to be one of the most important mechanisms contributing to the development and clinical course of chronic immunological diseases like allergies and asthma. DNA methylation has been extensively studied in this context, which has not been a case of histone modifications such as histone acetylation or methylation.
Early epigenetic studies from our lab conducted in mouse models demonstrated a role for histone acetylation in mediating bacteria-induced protection ag........ Read more »
Harb H, Alashkar Alhamwe B, Garn H, Renz H, & Potaczek DP. (2016) Recent developments in epigenetics of pediatric asthma. Current opinion in pediatrics, 28(6), 754-763. PMID: 27662207
Harb, H., Amarasekera, M., Ashley, S., Tulic, M., Pfefferle, P., Potaczek, D., Martino, D., Kesper, D., Prescott, S., & Renz, H. (2016) Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation. International Archives of Allergy and Immunology, 168(3), 173-181. DOI: 10.1159/000442158
Harb, H., Raedler, D., Ballenberger, N., Böck, A., Kesper, D., Renz, H., & Schaub, B. (2015) Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation. Journal of Allergy and Clinical Immunology, 136(1), 200-202. DOI: 10.1016/j.jaci.2015.01.027
Stefanowicz, D., Lee, J., Lee, K., Shaheen, F., Koo, H., Booth, S., Knight, D., & Hackett, T. (2015) Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects. Respiratory Research, 16(1). DOI: 10.1186/s12931-015-0254-y
by Rita Handrich in The Jury Room
We read so much for this blog (and just out of general curiosity) that we often find these small bits of information which don’t justify an entire blog post but that we want to share with you because they are just too good to ignore. Here’s another one of those combination posts that you simply […]... Read more »
Kaye LK, Malone SA, & Wall HJ. (2016) Emojis: Insights, Affordances, and Possibilities for Psychological Science. Trends in Cognitive Sciences. PMID: 28108281
One in 4 American Football players at the NFL Combine with a history of knee surgery have knee osteoarthritis despite being only 20 to 26 years of age.... Read more »
Smith MV, Nepple JJ, Wright RW, Matava MJ, & Brophy RH. (2016) Knee Osteoarthritis Is Associated With Previous Meniscus and Anterior Cruciate Ligament Surgery Among Elite College American Football Athletes. Sports health. PMID: 27940573
Of the various autism science journals out there in peer-reviewed (La-La!) land, one journal in particular is really starting to grow on me: [The] Review Journal of Autism and Developmental Disorders.I like this journal because it is basically systematic review and meta-analysis heaven when it comes to the quite voluminous autism research literature and seems to publish some real gems (see here for example).Another paper from this journal caught my eye recently by Maggie Butchart and colleagues ........ Read more »
Butchart, M., Long, J., Brown, M., McMillan, A., Bain, J., & Karatzias, T. (2017) Autism and Visual Impairment: a Review of the Literature. Review Journal of Autism and Developmental Disorders. DOI: 10.1007/s40489-016-0101-1
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