Post List

  • August 17, 2016
  • 05:01 AM
  • 108 views

76% of youths with autism meet ADHD diagnostic criteria? No, more like 59%

by Paul Whiteley in Questioning Answers

"In a population of children diagnosed with ASD [autism spectrum disorder], the rate of ADHD [attention-deficit hyperactivity disorder] + ASD was 42% and the rate of ADHD + ASD + ID [intellectual disability] was 17%, resulting in a 59% total comorbidity rate of ADHD and ASD."That was one of the important findings reported by Tara Stevens and colleagues [1] who using data from the Survey of Pathways to Diagnosis and Services (Pathways), a US initiative that has previ........ Read more »

  • August 17, 2016
  • 04:30 AM
  • 107 views

Integrating Injury Prevention in Schools!

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

An injury prevention warm-up two to three times a week in a junior high school physical education class decreased injuries and improved overall fitness.... Read more »

  • August 16, 2016
  • 05:01 PM
  • 129 views

A dog's dilemma: Do canines prefer praise or food?

by Dr. Jekyll in Lunatic Laboratories

A new study suggests that given the choice, many dogs prefer praise from their owners over food. The study is one of the first to combine brain-imaging data with behavioral experiments to explore canine reward preferences.

... Read more »

Cook, P., Prichard, A., Spivak, M., & Berns, G. (2016) Awake Canine fMRI Predicts Dogs’ Preference for Praise Versus Food. Social Cognitive and Affective Neuroscience. DOI: 10.1093/scan/nsw102  

  • August 16, 2016
  • 01:57 PM
  • 98 views

Science Without Open Data Isn't Science

by Neuroskeptic in Neuroskeptic_Discover

A new position paper published in the New England Journal of Medicine (NEJM) has generated a lot of controversy among some scientists: Toward Fairness in Data Sharing.

It's not hard to see why: the piece criticizes the concept of data sharing in the context of clinical trials. Data sharing is the much-discussed idea that researchers should make their raw data available to anyone who wants to access it. While the NEJM piece is specifically framed as a rebuttal to this recent pro-data sharing N... Read more »

International Consortium of Investigators for Fairness in Trial Data Sharing. (2016) Toward Fairness in Data Sharing. The New England journal of medicine, 375(5), 405-7. PMID: 27518658  

  • August 16, 2016
  • 10:43 AM
  • 109 views

The Angry Silence

by AG McCluskey in Zongo's Cancer Diaries

The experience of cancer patients has changed in many ways over the last 30 years. One massive improvement is that patients can talk about their diseases more freely.

And this may not just make them feel better, it might help to make them better too.......... Read more »

MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/

  • August 16, 2016
  • 04:36 AM
  • 146 views

Group A Streptococcal infections and paediatric neuropsychiatric disorders: Taiwan style

by Paul Whiteley in Questioning Answers

There they go again. Taiwan and their 'big data' publishing, yet again, some rather interesting population-based research trends derived from data from the National Health Insurance Research Database (NHIRD).This time around it is the paper by Han-Cheng Wang and colleagues [1] and the hypothesis to evaluate the "association between group A streptococcal (GAS) infections and the risks of developing tic disorders, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disord........ Read more »

  • August 15, 2016
  • 02:44 PM
  • 159 views

Prostitution has gone online -- and pimps are thriving

by Dr. Jekyll in Lunatic Laboratories

With the sale of sex shifting online, today's pimps are avoiding police detection by using underground websites, social media, mobile apps and even by hiding their ads on mainstream sites such as Craigslist and Backpage. In a first-of-its-kind study, criminologists interviewed 71 pimps in Atlanta and Chicago to determine how their marketing decisions are influenced by police enforcement of online prostitution.

... Read more »

  • August 15, 2016
  • 04:09 AM
  • 140 views

Offending behaviour and ADHD

by Paul Whiteley in Questioning Answers

"Although some associations between ADHD [attention-deficit hyperactivity disorder] and offending may be accounted for by co-morbidity with substance use disorders, early onset of offending and repeated violent offending appear to be directly related to ADHD."That was the conclusion reached by Jan Román-Ithier and colleagues [1] reporting on their study designed to "examine correlates of childhood ADHD symptoms among prisoners." Based on a sample adult prison population (N=1179) where........ Read more »

  • August 14, 2016
  • 05:40 PM
  • 148 views

Exercise can tackle symptoms of schizophrenia

by Dr. Jekyll in Lunatic Laboratories

Aerobic exercise can significantly help people coping with the long-term mental health condition schizophrenia, according to a new study. Through combining data from 10 independent clinical trials with a total of 385 patients with schizophrenia, Joseph Firth found that around 12 weeks of aerobic exercise training can significant improve patients' brain functioning.

... Read more »

  • August 13, 2016
  • 02:43 PM
  • 172 views

Intestinal flora effects drug response

by Dr. Jekyll in Lunatic Laboratories

Intestinal flora has multiple influences on human health, but researchers have revealed that it is also likely to have an effect on the body's response to drugs. Recent research suggests that changes in the intestinal flora, caused by antibacterial and antibiotic drugs or individual differences between people, may have an effect on a person's response to drugs including side effects. The research focused on the changes in proteins due to the condition of intestinal flora that affect th........ Read more »

  • August 13, 2016
  • 03:26 AM
  • 190 views

Inflammation is part of Gulf War Syndrome

by Paul Whiteley in Questioning Answers

Although mostly trying to avoid any politics-talk on this blog I am going to make some reference to it in this post set in the context of the Persian Gulf War otherwise known at the First Iraq War.The recent publication of the Chilcot report describing the case for the UK's involvement in the 2003 Iraq War (the second Iraq War) has further lit up an already illuminating year in British politics, by perhaps adding fuel to the notion that 'finishing the job' might have been an ........ Read more »

Johnson GJ, Slater BC, Leis LA, Rector TS, & Bach RR. (2016) Blood Biomarkers of Chronic Inflammation in Gulf War Illness. PloS one, 11(6). PMID: 27352030  

  • August 12, 2016
  • 03:37 PM
  • 236 views

Sugar addiction: Discovery of a brain sugar switch

by Dr. Jekyll in Lunatic Laboratories

Researchers have discovered that our brain actively takes sugar from the blood. Prior to this, researchers around the world had assumed that this was a purely passive process. An international team reports that transportation of sugar into the brain is regulated by so-called glial cells that react to hormones such as insulin or leptin; previously it was thought that this was only possible for neurons.

... Read more »

García-Cáceres, C., Quarta, C., Varela, L., Gao, Y., Gruber, T., Legutko, B., Jastroch, M., Johansson, P., Ninkovic, J., Yi, C.... (2016) Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell, 166(4), 867-880. DOI: 10.1016/j.cell.2016.07.028  

  • August 12, 2016
  • 07:00 AM
  • 37 views

Friday Fellow: Jataí Bee

by Piter Boll in Earthling Nature

by Piter Kehoma Boll Certainly the most widespread, adaptable and well-known honey-producing bee is Apis melifera, commonly known as honeybee for obvious reasons. But there are a lot of other honey makers all over the world. Today I’m going to present … Continue reading →... Read more »

  • August 12, 2016
  • 06:52 AM
  • 205 views

Discovering a glaring error in a research paper – a personal account

by Richard Kunert in Brain's Idea

New York Magazine has published a great article about how grad student Steven Ludeke tried to correct mistakes in the research of Pete Hatemi and Brad Verhulst. Overall, Ludeke summarises his experience as ‘not recommendable’. Back in my undergraduate years I spotted an error in an article by David DeMatteo and did little to correct it. […]... Read more »

  • August 12, 2016
  • 05:10 AM
  • 154 views

Simulation study suggests that mutations induce conformational changes in FLCN - possible cause of Birt-Hogg-Dubé syndrome

by Joana Guedes in BHD Research Blog

Germline mutations of the folliculin gene are normally responsible for Birt–Hogg–Dubé (BHD) syndrome. The 3D structure of the C-terminal domain of folliculin (FLCN), folliculin-CT, has been previously determined (Nookala et al., 2012). FLCN is a tumor suppressor and a guanine nucleotide exchange factor (GEF) for Rab35. GEF activity of FLCN towards its GTPase might be essential for cellular processes. Most of the reported FLCN mutations lead to the BHD phenotype (Lim et al., 20........ Read more »

  • August 12, 2016
  • 04:22 AM
  • 190 views

Anti-psychotics for non-psychotic issues

by Paul Whiteley in Questioning Answers

A bit of a lazy post for you today with lots of quotes based on the findings reported by Ragnar Nesvåg and colleagues [1] asking some important questions about 'off-label' use of antipsychotics.Drawing on population-based data from Norway concerning "which substances, and for which mental disorder diagnoses, antipsychotic drugs were prescribed to 0–18-year-old boys and girls" the conclusions drawn make for some interesting reading.So: "In total, 0.18% of Norwegian children and adolescent........ Read more »

Nesvåg, R., Hartz, I., Bramness, J., Hjellvik, V., Handal, M., & Skurtveit, S. (2016) Mental disorder diagnoses among children and adolescents who use antipsychotic drugs. European Neuropsychopharmacology. DOI: 10.1016/j.euroneuro.2016.07.001  

  • August 11, 2016
  • 08:30 PM
  • 169 views

Acupuncture vs intravenous morphine in the management of acute pain in the ED

by Rogue Medic in Rogue Medic

Should we have people providing "fake" acupuncture in the Emergency Department?

If so, how should we do this?

Since it is not the acupuncture, but the patient's reaction to the "ceremony of the placebo" that appears to be providing the pain relief, how many different ways might we vary the "treatment" to improve the placebo effect?... Read more »

Grissa, M., Baccouche, H., Boubaker, H., Beltaief, K., Bzeouich, N., Fredj, N., Msolli, M., Boukef, R., Bouida, W., & Nouira, S. (2016) Acupuncture vs intravenous morphine in the management of acute pain in the ED. The American Journal of Emergency Medicine. DOI: 10.1016/j.ajem.2016.07.028  

Espay, A., Norris, M., Eliassen, J., Dwivedi, A., Smith, M., Banks, C., Allendorfer, J., Lang, A., Fleck, D., Linke, M.... (2015) Placebo effect of medication cost in Parkinson disease: A randomized double-blind study. Neurology, 84(8), 794-802. DOI: 10.1212/WNL.0000000000001282  

Ee, C., Xue, C., Chondros, P., Myers, S., French, S., Teede, H., & Pirotta, M. (2016) Acupuncture for Menopausal Hot Flashes. Annals of Internal Medicine, 164(3), 146. DOI: 10.7326/M15-1380  

Cherkin, D., Sherman, K., Avins, A., Erro, J., Ichikawa, L., Barlow, W., Delaney, K., Hawkes, R., Hamilton, L., Pressman, A.... (2009) A Randomized Trial Comparing Acupuncture, Simulated Acupuncture, and Usual Care for Chronic Low Back Pain. Archives of Internal Medicine, 169(9), 858. DOI: 10.1001/archinternmed.2009.65  

Goldman, R., Stason, W., Park, S., Kim, R., Schnyer, R., Davis, R., Legedza, A., & Kaptchuk, T. (2008) Acupuncture for Treatment of Persistent Arm Pain Due to Repetitive Use. The Clinical Journal of Pain, 24(3), 211-218. DOI: 10.1097/AJP.0b013e31815ec20f  

  • August 11, 2016
  • 02:04 PM
  • 177 views

Targeting the gut-brain connection can impact immunity

by Dr. Jekyll in Lunatic Laboratories

There's a reason it's called a gut feeling. The brain and the gut are connected by intricate neural networks that signal hunger and satiety, love and fear, even safety and danger. These networks employ myriad chemical signals that include dopamine, a powerful neurotransmitter most famous for its role in reward and addiction.

... Read more »

Xiou Cao, & Alejandro Aballay. (2016) Neural inhibition of dopaminergic signaling enhances immunity in a cell non-autonomous manner. Current Biology. info:/http://dx.doi.org/10.1016/j.cub.2016.06.036

  • August 11, 2016
  • 08:41 AM
  • 210 views

Who made the Piltdown man? Inside one of science’s most (in)famous hoaxes

by gdw in FictionalFieldwork

There was always that nagging feeling of not being accepted, of whispers behind his back. They pretended to be open-minded, but in reality not belonging to the group of professionals was reason enough to dismiss his work and findings. In their eyes, he was just a solicitor. A hobbyist. He was tolerated, but their derision […]... Read more »

De Groote, I., Flink, L., Abbas, R., Bello, S., Burgia, L., Buck, L., Dean, C., Freyne, A., Higham, T., Jones, C.... (2016) New genetic and morphological evidence suggests a single hoaxer created ‘Piltdown man’. Royal Society Open Science, 3(8), 160328. DOI: 10.1098/rsos.160328  

  • August 11, 2016
  • 04:35 AM
  • 195 views

Induced labour and autism (again)

by Paul Whiteley in Questioning Answers

"In this nationwide sample of live births we observed no association between induction of labor and offspring ASD [autism spectrum disorder] within sibling comparison. Our findings suggest that concern for ASD should not factor into the clinical decision about whether to induce labor."So said the findings reported by Anna Sara Oberg and colleagues [1] supposedly providing some reassurance to mums-to-be and other groups around the likelihood of offspring autism when birth or l........ Read more »

Oberg, A., D’Onofrio, B., Rickert, M., Hernandez-Diaz, S., Ecker, J., Almqvist, C., Larsson, H., Lichtenstein, P., & Bateman, B. (2016) Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders. JAMA Pediatrics. DOI: 10.1001/jamapediatrics.2016.0965  

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