67 posts · 59,718 views
the Node is a community blog for and by developmental biologists.
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- March 7, 2013
- 09:22 AM
- 141 views
Stripes and Stem Cells
by Erin Campbell in the Node
You didn’t stop developing once you were born (or hatched). Our infant selves barely resemble ourselves as adults, thankfully, and stem cells play an important role in this continued development. A recent paper describes the identification of a stem cell niche that generates the melanophores that are responsible for the color patterning in adult zebrafish. [...]... Read more »
Dooley, C., Mongera, A., Walderich, B., & Nusslein-Volhard, C. (2013) On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. Development, 140(5), 1003-1013. DOI: 10.1242/dev.087007
- February 15, 2013
- 10:47 AM
- 188 views
Stem cell decisions and the cell cycle
by Erin Campbell in the Node
A lot of things cycle in life, even down to the cellular level. In the developing central nervous system, regulators of the cell cycle play important roles in maintaining the balance between stem cell self-renewal and differentiation. A recent paper in the journal Development describes a cell cycle regulator in stem and progenitor cells in [...]... Read more »
Liang, H., Xiao, G., Yin, H., Hippenmeyer, S., Horowitz, J., & Ghashghaei, H. (2013) Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development, 140(3), 552-561. DOI: 10.1242/dev.085621
- February 7, 2013
- 11:36 AM
- 50 views
Review: Electric shock
Last year, Matter launched, after a successful Kickstarter campaign, as a magazine that publishes only long, well-written articles related to “science, technology and the ideas shaping our future”. Each issue is one article, which costs $0.99 to access. (On my iPad, they ‘re categorized as books, and are each about 40 pages long, which I [...]... Read more »
Tseng AiSun, & Levin Michael. (2013) Cracking the bioelectric code: Probing endogenous ionic controls of pattern formation. Communicative , 6(1). DOI: 10.4161/cib.22595
Tseng A.-S., Beane W. S., Lemire J. M., Masi A., & Levin M. (2010) Induction of Vertebrate Regeneration by a Transient Sodium Current. Journal of Neuroscience, 30(39), 13192-13200. DOI: 10.1523/JNEUROSCI.3315-10.2010
Beane W. S., Morokuma J., Lemire J. M., & Levin M. (2013) Bioelectric signaling regulates head and organ size during planarian regeneration. Development, 140(2), 313-322. DOI: 10.1242/dev.086900
Pai V. P., Aw S., Shomrat T., Lemire J. M., & Levin M. (2012) Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis. Development, 139(2), 313-323. DOI: 10.1242/dev.073759
- January 14, 2013
- 05:02 PM
- 128 views
Hope for Huntington’s
by Erin Campbell in the Node
Every time a biologist drives pluripotent cells to differentiate into a specialized cell type, patients of all sorts of diseases, disorders, and injuries allow their hope to grow. A research group recently reported how to drive differentiation of human pluripotent stem cells into medium-sized spiny neurons, the neurons that are some of the first to [...]... Read more »
Carri, A., Onorati, M., Lelos, M., Castiglioni, V., Faedo, A., Menon, R., Camnasio, S., Vuono, R., Spaiardi, P., Talpo, F.... (2012) Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32 medium-sized spiny neurons. Development, 140(2), 301-312. DOI: 10.1242/dev.084608
- December 12, 2012
- 04:17 PM
- 167 views
Don’t get rid of the middleman
by Erin Campbell in the Node
There are a lot of situations in life where the “middleman” is unnecessary and costly. In cells, that middleman is necessary and fascinating at the same time. The sequence of DNA to middleman mRNA to protein provides our cells with countless ways to regulate complex events, including those surrounding stem cell divisions. When stem cells [...]... Read more »
Eun, S., Stoiber, P., Wright, H., McMurdie, K., Choi, C., Gan, Q., Lim, C., & Chen, X. (2012) MicroRNAs downregulate Bag of marbles to ensure proper terminal differentiation in the Drosophila male germline. Development, 140(1), 23-30. DOI: 10.1242/dev.086397
- October 26, 2012
- 04:50 PM
- 135 views
The embryonic cell lineage of C. elegans, revisited and revisualized
by Andrew Chisholm in the Node
On my desk sits a tattered photocopy of one of the pinnacles of modern developmental biology, the “embryonic lineage” paper by John Sulston, et al. (1983). In this paper, Sulston et al. completed a project begun in the late 19th century, namely to trace the complete genealogy of all cells in a nematode embryo. C. [...]... Read more »
Giurumescu C. A., Kang S., Planchon T. A., Betzig E., Bloomekatz J., Yelon D., Cosman P., & Chisholm A. D. (2012) Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos. Development, 139(22), 4279. DOI: 10.1242/dev.086256
- October 10, 2012
- 03:49 PM
- 142 views
Worms teach about germline stem cells
by Erin Campbell in the Node
To me, the stem cells within a germline are a perfect storm of fascination. Stem cells are, of course, intriguing in their ability to self-renew and differentiate, and a germline is intriguing in its ability to generate gametes. Add stem cells and germlines together, and you have amazing biology in front of you…and more biology [...]... Read more »
Ekaterina Voronina, Alexandre Paix, & Geraldine Seydoux. (2012) The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells. Development, 139(20), 3732-3740. DOI: 10.1242/dev.083980
- August 21, 2012
- 05:52 AM
- 269 views
Virtual nanoscopy
Let’s take a very close look at the inside of a fish! A recent paper in the Journal of Cell Biology describes a technique for generating large, composite, images from electron microscopy data. Frank Faas, Raimond Ravelli, and colleagues at the Leiden University Medical Center developed a method to computationally collect and align EM images. [...]... Read more »
Faas FG, Avramut MC, M van den Berg B, Mommaas AM, Koster AJ, & Ravelli RB. (2012) Virtual nanoscopy: Generation of ultra-large high resolution electron microscopy maps. The Journal of cell biology, 198(3), 457-69. PMID: 22869601
- August 13, 2012
- 09:43 PM
- 191 views
A stem cell needs REST
by Erin Campbell in the Node
Decisions, decisions. Stem cells face the task to self-renew or differentiate, a decision made out of the combination and coordination of numerous regulators. With the activation or suppression of transcriptional activators and the activation or suppression of repressors, it’s easy to see how understanding this process is anything BUT easy. Today’s images are from a [...]... Read more »
Covey MV, Streb JW, Spektor R, & Ballas N. (2012) REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells. Development (Cambridge, England), 139(16), 2878-90. PMID: 22791895
- August 13, 2012
- 03:24 PM
- 303 views
Colouring the Mouse Embryo
by wongmi22 in the Node
48 anatomical structures of the presented mouse embryo atlas are shown in 3D. Here is the backdrop for our recent paper in Development, “A novel 3D mouse embryo atlas based on micro-CT”. With the human genome project complete, the sequence and the location of each gene in the genome is understood. However, the understanding of [...]... Read more »
Wong MD, Dorr AE, Walls JR, Lerch JP, & Henkelman RM. (2012) A novel 3D mouse embryo atlas based on micro-CT. Development (Cambridge, England), 139(17), 3248-56. PMID: 22872090
- August 1, 2012
- 12:07 PM
- 347 views
What’s in the culture medium in IVF labs?
British researchers working with human embryos for IVF have been wondering about the effects of components of the culture medium they use. In the UK, culture media used for IVF and fertility research are regulated by the Medicines and Healthcare Regulatory Agency (MHRA) and at European level. Regulation ensures that all researchers and clinicians in [...]... Read more »
Harper J, Magli MC, Lundin K, Barratt CL, & Brison D. (2012) When and how should new technology be introduced into the IVF laboratory?. Human reproduction (Oxford, England), 27(2), 303-13. PMID: 22166806
Dumoulin JC, Land JA, Van Montfoort AP, Nelissen EC, Coonen E, Derhaag JG, Schreurs IL, Dunselman GA, Kester AD, Geraedts JP.... (2010) Effect of in vitro culture of human embryos on birthweight of newborns. Human reproduction (Oxford, England), 25(3), 605-12. PMID: 20085915
- July 30, 2012
- 09:29 PM
- 180 views
Uncovering the unexpected: New visions from the 3’ end of squint
by Shimin Lim in the Node
Here I share the background story on my graduate work that was recently published in Development, “Dorsal activity of maternal squint is mediated by a non-coding function of the RNA”: I first joined Karuna Sampath’s group at Temasek Life Sciences Laboratory in 2005 during my undergraduate days. It was an exciting year in the lab [...]... Read more »
Shimin Lim, Pooja Kumari, Patrick Gilligan, Helen Ngoc Bao Quach, Sinnakaruppan Mathavan, & Karuna Sampath. (2012) Dorsal activity of maternal squint is mediated by a non-coding function of the RNA . Development, 139(16). info:/10.1242/dev.077081
- July 27, 2012
- 04:05 AM
- 211 views
Piecing together the squint puzzle
by Karuna in the Node
Here is the backdrop for our recent paper in Development, “Dorsal activity of maternal squint is mediated by a non-coding function of the RNA”: This work follows up a previous publication from my laboratory where we showed that knock-down of maternal squint (sqt) or ablation of sqt-containing cells led to loss of dorsal structures in [...]... Read more »
Shimin Lim, Pooja Kumari, Patrick Gilligan, Helen Ngoc Bao Quach, Sinnakaruppan Mathavan, & Karuna Sampath. (2012) Dorsal activity of maternal squint is mediated by a non-coding function of the RNA . Development, 139(16). info:/10.1242/dev.077081
- July 10, 2012
- 05:07 PM
- 352 views
Moderation is key
by Erin Campbell in the Node
Mae West was no biologist when she told us all that “Too much of a good thing can be wonderful.” I shudder to think how little development would take place if any one cell type was produced in large amounts. Thankfully, stem cells and those involved in tissue regeneration understand the importance of moderation. Today’s [...]... Read more »
Li S, Wang Y, Zhang Y, Lu MM, Demayo FJ, Dekker JD, Tucker PW, & Morrisey EE. (2012) Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development (Cambridge, England), 139(14), 2500-9. PMID: 22675208
- June 13, 2012
- 03:00 PM
- 332 views
Affordable Fluorescence
by Paul O'Neill in the Node
Report on technological breakthrough from the Wakayama lab. Could lower costs and increase access to fluorescent microscopy. ... Read more »
Yamagata K, Iwamoto D, Terashita Y, Li C, Wakayama S, Hayashi-Takanaka Y, Kimura H, Saeki K, & Wakayama T. (2012) Fluorescence cell imaging and manipulation using conventional halogen lamp microscopy. PloS one, 7(2). PMID: 22347500
- May 10, 2012
- 04:02 PM
- 492 views
Smart signaling in the developing brain
by Erin Campbell in the Node
The WNT pathway functions in so many processes during development that it is easy to be jealous of its multi-tasking abilities. A recent paper in Development describes the role of WNT signaling in neural stem cell proliferation. WNT signaling plays an important role in neural development, axon guidance, cell polarity, and stem cell biology. WNT [...]... Read more »
Pei, Y., Brun, S., Markant, S., Lento, W., Gibson, P., Taketo, M., Giovannini, M., Gilbertson, R., & Wechsler-Reya, R. (2012) WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development, 139(10), 1724-1733. DOI: 10.1242/dev.050104
- April 27, 2012
- 04:09 AM
- 362 views
Interview with Beddington Medal winner Boyan Bonev
Each year, the British Society for Developmental Biology awards the Beddington Medal for the best PhD thesis in developmental biology. At the 2012 BSDB meeting, this award went to Boyan Bonev, who completed his PhD in Nancy Papalopulu’s lab at the University of Manchester. At the conference, Boyan gave a talk about his PhD work, [...]... Read more »
Bonev, B., Pisco, A., & Papalopulu, N. (2011) MicroRNA-9 Reveals Regional Diversity of Neural Progenitors along the Anterior-Posterior Axis. Developmental Cell, 20(1), 19-32. DOI: 10.1016/j.devcel.2010.11.018
Dajas-Bailador, F., Bonev, B., Garcez, P., Stanley, P., Guillemot, F., & Papalopulu, N. (2012) microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons. Nature Neuroscience, 15(5), 697-699. DOI: 10.1038/nn.3082
- April 12, 2012
- 02:23 PM
- 494 views
Stem cells at home
by Erin Campbell in the Node
We depend on our own comfort zones to keep us grounded, and stem cells are no different. A recent paper in Development describes how the adhesion that keeps a stem cell in its niche is regulated. A stem cell’s niche is important in maintaining its long-term undifferentiated state. A great model of stem cell niche [...]... Read more »
Srinivasan, S., Mahowald, A., & Fuller, M. (2012) The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche. Development, 139(8), 1381-1390. DOI: 10.1242/dev.070052
- April 3, 2012
- 12:57 AM
- 582 views
Photo-Morpholinos
by Philip Washbourne in the Node
In the study of the roles of genes during development, one problem that is often faced by researchers examining ‘late’ roles of genes is one of obscuration by temporal pleiotropy. That is: gene mutations and gene knock-down obscure late roles in development, because early phenotypes, such as cell death or malformed embryos, make it impossible [...]... Read more »
Alexandra Tallafuss, Dan Gibson, Paul Morcos, Yongfu Li, Steve Seredick, Judith Eisen, & Philip Washbourne. (2012) Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish. Development, 139(9), 1691-1699. info:/10.1242/dev.075390
- March 8, 2012
- 11:33 AM
- 572 views
Differences between mammals begin early in development
by Erin Campbell in the Node
The progress of stem cell research depends on the ability to grow stem cells in culture. Embryonic stem (ES) cells from some organisms, such as humans, have proven difficult to culture. While it is known that there are differences in early development between even closely-related species, understanding where these differences begin will help biologists understand [...]... Read more »
Kuijk, E., van Tol, L., Van de Velde, H., Wubbolts, R., Welling, M., Geijsen, N., & Roelen, B. (2012) The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos. Development, 139(5), 871-882. DOI: 10.1242/dev.071688
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