10 posts · 7,205 views
JUNIORPROF is a blog about making it as a young scientist in a tenure track position at an R1 Medical School. Its also about pharmacology, neuroscience and pain research
JUNIORPROF
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- October 21, 2010
- 09:47 AM
- 641 views
A pain drug discovery success story: anti-NGF therapy for osteoarthritis
by JUNIORPROF in JUNIORPROF
With all the recent layoffs in Pharma, coupled with the axing of many analgesic drug development programs within these institutions, its nice to finally see a success (albeit of potentially short longevity — more on that later). The treatment is … Continue reading →... Read more »
Lane, N., Schnitzer, T., Birbara, C., Mokhtarani, M., Shelton, D., Smith, M., & Brown, M. (2010) Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee. New England Journal of Medicine, 363(16), 1521-1531. DOI: 10.1056/NEJMoa0901510
- September 30, 2010
- 10:03 AM
- 619 views
A new mechanism of action for Selective Serotonin Reuptake Inhibitors (SSRIs)?: Pharm 551A, Baudry et al., 2010
by JUNIORPROF in JUNIORPROF
This is the last paper for the first section of the class and, as such, it serves as a transition from basic drug discovery work to the next section of the class, the pharmacology of gene expression. The paper, MiR-16 … Continue reading →... Read more »
Baudry, A., Mouillet-Richard, S., Schneider, B., Launay, J., & Kellermann, O. (2010) MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants. Science, 329(5998), 1537-1541. DOI: 10.1126/science.1193692
- September 28, 2010
- 09:56 AM
- 577 views
Targeting GPCR – Gbeta/gamma with small molecules, Pharm 551A: Bonacci et al., 2006
by JUNIORPROF in JUNIORPROF
Our understanding of G protein-coupled receptors (GPCRs) has been greatly aided by their relative tractability in terms of pharmacological targeting. These receptors are fairly easy to express in cells and their signaling pathways are amenable to high throughput screening (HTS) … Continue reading →... Read more »
Bonacci, T. (2006) Differential Targeting of G -Subunit Signaling with Small Molecules. Science, 312(5772), 443-446. DOI: 10.1126/science.1120378
- September 21, 2010
- 03:41 PM
- 788 views
Agonist-directed trafficking of receptor stimulus, Pharm 551A: Berg et al., 1998
by JUNIORPROF in JUNIORPROF
After doing a whole bunch of cutting-edge papers for the class its time to go back in time a bit (like 1998 is ancient but anyways) and do an oldie-but-goodie. This particular paper, “Effector Pathway-Dependent Relative Efficacy at Serotonin Type … Continue reading →... Read more »
Berg KA, Maayani S, Goldfarb J, Scaramellini C, Leff P, & Clarke WP. (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Molecular pharmacology, 54(1), 94-104. PMID: 9658194
- September 17, 2010
- 09:56 AM
- 662 views
First step toward the holy grail of pain research? Molecular identity of a mechanically gated ion channel, Coste et al., 2010 Science
by JUNIORPROF in JUNIORPROF
For as long as I have been in pain research (and long before I ever even thought about pain research) the topic of mechanically-gated ion channels has been a huge deal. The reasons are simple: 1) We obtain information about … Continue reading →... Read more »
Coste, B., Mathur, J., Schmidt, M., Earley, T., Ranade, S., Petrus, M., Dubin, A., & Patapoutian, A. (2010) Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels. Science. DOI: 10.1126/science.1193270
- September 16, 2010
- 10:29 AM
- 716 views
Identifying novel inhibitors for uncharacterized enzymes, Pharm 551A: Bachovchin et al., 2009
by JUNIORPROF in JUNIORPROF
Today is our last paper on high throughput screening (HTS) techniques. We’re back to discovering drugs on this one but the premise is quite different for this particular screen. Whereas other papers we’ve done so far have involved finding novel … Continue reading →... Read more »
Bachovchin, D., Brown, S., Rosen, H., & Cravatt, B. (2009) Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nature biotechnology, 27(4), 387-394. DOI: 10.1038/nbt.1531
- September 14, 2010
- 10:30 AM
- 853 views
Identifying tumor suppressor genes through an in vivo RNA interference screen, Pharm 551A: Bric et al., 2009
by JUNIORPROF in JUNIORPROF
On the agenda for today is another paper about screening (one more to go after this one): Bric et al., (2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model [PMC]. This … Continue reading →... Read more »
Bric, A., Miething, C., Bialucha, C., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M., & Hicks, J. (2009) Functional Identification of Tumor-Suppressor Genes through an In Vivo RNA Interference Screen in a Mouse Lymphoma Model. Cancer Cell, 16(4), 324-335. DOI: 10.1016/j.ccr.2009.08.015
- September 14, 2010
- 09:11 AM
- 693 views
Predicting new molecular targets for known drugs, Pharm 551A: Keiser et al., 2009
by JUNIORPROF in JUNIORPROF
On the agenda today is a fascinating paper titled: predicting new molecular targets for known drugs, Keiser et al., Nature 2009 [PMC]. This is one of my favorite papers of the past two years. I have to admit that it … Continue reading →... Read more »
Keiser, M., Setola, V., Irwin, J., Laggner, C., Abbas, A., Hufeisen, S., Jensen, N., Kuijer, M., Matos, R., Tran, T.... (2009) Predicting new molecular targets for known drugs. Nature, 462(7270), 175-181. DOI: 10.1038/nature08506
- September 14, 2010
- 09:10 AM
- 763 views
Quantifying biogenic bias in screening libraries, Pharm 551A: Hert et al. 2009
by JUNIORPROF in JUNIORPROF
Today’s paper [PMC] is Hert et al., (2009) Quantifying biogenic bias in screening libraries. At issue for todays class is a discussion about one of the first steps in drug discovery, compound library selection and generation. The authors of this … Continue reading →... Read more »
Hert, J., Irwin, J., Laggner, C., Keiser, M., & Shoichet, B. (2009) Quantifying biogenic bias in screening libraries. Nature Chemical Biology, 5(7), 479-483. DOI: 10.1038/nchembio.180
- September 14, 2010
- 09:09 AM
- 893 views
Rapid behavior-based identification of neuroactive small molecules in the zebrafish, Pharm 551A: Kokel et al., 2010
by JUNIORPROF in JUNIORPROF
Today’s paper is a continuation of our discussion on screening compounds for drug discovery: Kokel et al, 2010 Rapid behavior-based identification of neuroactive small molecules in the zebrafish, Nature Chemical Biology [PMC]. Having just returned from the IASP meeting in … Continue reading →... Read more »
Kokel, D., Bryan, J., Laggner, C., White, R., Cheung, C., Mateus, R., Healey, D., Kim, S., Werdich, A., Haggarty, S.... (2010) Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nature Chemical Biology, 6(3), 231-237. DOI: 10.1038/nchembio.307
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