10 posts · 7,205 views
JUNIORPROF is a blog about making it as a young scientist in a tenure track position at an R1 Medical School. Its also about pharmacology, neuroscience and pain research
With all the recent layoffs in Pharma, coupled with the axing of many analgesic drug development programs within these institutions, its nice to finally see a success (albeit of potentially short longevity — more on that later). The treatment is … Continue reading →... Read more »
Lane, N., Schnitzer, T., Birbara, C., Mokhtarani, M., Shelton, D., Smith, M., & Brown, M. (2010) Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee. New England Journal of Medicine, 363(16), 1521-1531. DOI: 10.1056/NEJMoa0901510
This is the last paper for the first section of the class and, as such, it serves as a transition from basic drug discovery work to the next section of the class, the pharmacology of gene expression. The paper, MiR-16 … Continue reading →... Read more »
Baudry, A., Mouillet-Richard, S., Schneider, B., Launay, J., & Kellermann, O. (2010) MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants. Science, 329(5998), 1537-1541. DOI: 10.1126/science.1193692
Our understanding of G protein-coupled receptors (GPCRs) has been greatly aided by their relative tractability in terms of pharmacological targeting. These receptors are fairly easy to express in cells and their signaling pathways are amenable to high throughput screening (HTS) … Continue reading →... Read more »
Bonacci, T. (2006) Differential Targeting of G -Subunit Signaling with Small Molecules. Science, 312(5772), 443-446. DOI: 10.1126/science.1120378
After doing a whole bunch of cutting-edge papers for the class its time to go back in time a bit (like 1998 is ancient but anyways) and do an oldie-but-goodie. This particular paper, “Effector Pathway-Dependent Relative Efficacy at Serotonin Type … Continue reading →... Read more »
Berg KA, Maayani S, Goldfarb J, Scaramellini C, Leff P, & Clarke WP. (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Molecular pharmacology, 54(1), 94-104. PMID: 9658194
For as long as I have been in pain research (and long before I ever even thought about pain research) the topic of mechanically-gated ion channels has been a huge deal. The reasons are simple: 1) We obtain information about … Continue reading →... Read more »
Coste, B., Mathur, J., Schmidt, M., Earley, T., Ranade, S., Petrus, M., Dubin, A., & Patapoutian, A. (2010) Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels. Science. DOI: 10.1126/science.1193270
Today is our last paper on high throughput screening (HTS) techniques. We’re back to discovering drugs on this one but the premise is quite different for this particular screen. Whereas other papers we’ve done so far have involved finding novel … Continue reading →... Read more »
Bachovchin, D., Brown, S., Rosen, H., & Cravatt, B. (2009) Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nature biotechnology, 27(4), 387-394. DOI: 10.1038/nbt.1531
On the agenda for today is another paper about screening (one more to go after this one): Bric et al., (2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model [PMC]. This … Continue reading →... Read more »
Bric, A., Miething, C., Bialucha, C., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M., & Hicks, J. (2009) Functional Identification of Tumor-Suppressor Genes through an In Vivo RNA Interference Screen in a Mouse Lymphoma Model. Cancer Cell, 16(4), 324-335. DOI: 10.1016/j.ccr.2009.08.015
On the agenda today is a fascinating paper titled: predicting new molecular targets for known drugs, Keiser et al., Nature 2009 [PMC]. This is one of my favorite papers of the past two years. I have to admit that it … Continue reading →... Read more »
Today’s paper [PMC] is Hert et al., (2009) Quantifying biogenic bias in screening libraries. At issue for todays class is a discussion about one of the first steps in drug discovery, compound library selection and generation. The authors of this … Continue reading →... Read more »
Today’s paper is a continuation of our discussion on screening compounds for drug discovery: Kokel et al, 2010 Rapid behavior-based identification of neuroactive small molecules in the zebrafish, Nature Chemical Biology [PMC]. Having just returned from the IASP meeting in … Continue reading →... Read more »
Kokel, D., Bryan, J., Laggner, C., White, R., Cheung, C., Mateus, R., Healey, D., Kim, S., Werdich, A., Haggarty, S.... (2010) Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nature Chemical Biology, 6(3), 231-237. DOI: 10.1038/nchembio.307
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.