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A researcher's blog on neuroscience, psychiatry, and psychology. An attempt to fill the space between science journalism and journal articles.
5-hydroxy-methyl CpGs (5-hmCs) were first discovered in 2009 and shown to be enriched in the brain, but remain a mysterious epigenetic mark, despite intriguing functional findings such as: environmental enrichment’s reduction of it, MeCP2′s preference for 5mc over 5hmc, and it’s possible role as an intermediate in demethylation. This new technique will aid their characterization by allowing absolute quantification and base-resolution localization of the marks. The technique als........ Read more »
Yu M, Hon GC, Szulwach KE, Song CX, Zhang L, Kim A, Li X, Dai Q, Shen Y, Park B.... (2012) Base-resolution analysis of 5-hydroxymethylcytosine in the Mammalian genome. Cell, 149(6), 1368-80. PMID: 22608086
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