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Autism research and other musings

Paul Whiteley
1,230 posts

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  • August 14, 2012
  • 09:17 PM

Propionic acid and autism

by Paul Whiteley in Questioning Answers

Another post, another organic acid (!) but please don't click away just yet as I attempt once again not to blind you with science. The topic of the day today is propionic acid (PPA) otherwise known as propanoic acid and the very tentative suggestions of some link to autism. Search on-line for propionic acid and you're quite likely to get lots of industrial chemical information about it including a materials safety data sheet (MSDS) (here) implying that this stuff is toxic, combust........ Read more »

  • August 13, 2012
  • 06:37 AM

No single SNP associated with autism?

by Paul Whiteley in Questioning Answers

A quote to begin this relatively short post:"Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level."One of the conclusions reached in this article by Richard Anney and colleagues* (full-text). SNPs (single nucleotide polymorphism(s) are the tiny rearrangements in our genetic code which have all but replaced the older research fashion of one gene - one condition from times gone by. The theory ........ Read more »

Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bölte S, Bolton PF, Bourgeron T.... (2012) Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Human molecular genetics. PMID: 22843504  

  • August 10, 2012
  • 10:38 AM

Folate and autism: more questions than answers

by Paul Whiteley in Questioning Answers

Athenian sunset @ Paul WhiteleyI don't know if you could tell but my previous few blog posts were a sort of stand-in whilst I took a few days off. Not exactly repeats of favourite soap operas or anything like that, but more like watching some pre-recorded non-league football (soccer) compared to the Premiership live. Suffice to say that I'm back now and ready to press on with some 'proper' posts.Whilst away I've been thinking quite a bit about the paper from Rebecca Schmidt and colleagues* ........ Read more »

  • July 19, 2012
  • 05:33 AM

Mouse modeling, immune function and autism

by Paul Whiteley in Questioning Answers

Contrary to the title of this post and any images that it may conjure up of mice parading down a runway in this season's 'hottest looks' whilst pouting to the clicks and flashes of multiple cameras, I'm back to mouse models and autism again(!) and an interesting piece of research by Hsiao and colleagues*.I am kinda standing on the shoulders of giants with this paper given that it comes from the laboratory of Paul Patterson who has already run with a short description about it on his blog (see he........ Read more »

Hsiao EY, McBride SW, Chow J, Mazmanian SK, & Patterson PH. (2012) Modeling an autism risk factor in mice leads to permanent immune dysregulation. Proceedings of the National Academy of Sciences of the United States of America. PMID: 22802640  

  • July 18, 2012
  • 05:39 AM

Anxious children and autism traits?

by Paul Whiteley in Questioning Answers

I'm always been quite intrigued by studies examining the various behaviours linked to autism presenting in other conditions not necessarily linked to autism as a discrete entity. The various studies done on eating disorders* spring to mind as quite a good example.This type of research - when it shows some positive correlation - kinda reiterates that when we talk about autism, we aren't so much talking about a single homogeneous condition, but perhaps rather a range of conditions which share some........ Read more »

van Steensel FJ, Bögels SM, & Wood JJ. (2012) Autism Spectrum Traits in Children with Anxiety Disorders. Journal of autism and developmental disorders. PMID: 22733297  

  • July 13, 2012
  • 08:37 AM

Brain glutathione redox status, Brussels sprouts and autism?

by Paul Whiteley in Questioning Answers

Sprouts, sprouts, sprouts @ WikipediaGlutathione in relation to autism spectrum conditions is a bit of a favourite topic of mine. I've talked about glutathione a few times on this blog (here and here) and how the various reports on a reduced level of functioning of this fantastic part of our antioxidant system seem to show more than a passing connection to cases of autism. That and the fact that consumption of a favourite foodstuff of mine, the Brussels sprout, might have quite a positive influe........ Read more »

  • July 12, 2012
  • 08:20 AM

Autism and the family tree

by Paul Whiteley in Questioning Answers

A blog post discussing the suggestion that a family history of schizophrenia and/or bipolar disorder may be a risk factor for autism... Read more »

  • February 15, 2012
  • 02:19 PM

The glutamate:glutamine ratio and autism

by Paul Whiteley in Questioning Answers

On the issue of the glutamate-glutamine ratio in cases of autism... Read more »

  • February 13, 2012
  • 11:11 AM

High lactate levels reported in about 1 in 5 children with ASD

by Paul Whiteley in Questioning Answers

Elevated lactate levels seem to be a feature of some cases of autism... Read more »

Oliveira, G., Diogo, L., Grazina, M., Garcia, P., Psych, A., Marques, C., Miguel, T., Borges, L., Vicente, A., & Oliveira, C. (2007) Mitochondrial dysfunction in autism spectrum disorders: a population-based study. Developmental Medicine , 47(3), 185-189. DOI: 10.1111/j.1469-8749.2005.tb01113.x  

  • January 10, 2012
  • 10:33 PM

Autism and Sutterella

by Paul Whiteley in Questioning Answers

The first report on the identification of Sutterella spp following analysis of gut bacteria from children with autism... Read more »

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