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EpiBeat is an epigenetics resource and community for you to stay up-to-date and join the conversation on the rapidly expanding field of epigenetics. Here, you can read and discuss summaries of some of our favorite new epigenetic publications, each presented succinctly so you can keep current with the literature without having to read every paper in detail. It’s a simple way to keep with the beat in epigenetics! We also make it easy to learn more about epigenetics, get tips & tricks from the industry, ask questions about your research and get answers from other scientists. EpiBeat was created for scientists by scientists and is hosted by Zymo Research, The Epigenetics Company.

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  • March 15, 2017
  • 08:30 AM
  • 124 views

CHL1 Hypermethylation in Breast Cancer

by Esperanza Martín Sánchez in EpiBeat

Breast cancer (BC) is the most common cancer among women and one of the leading causes of cancer-related deaths worldwide (1-3). It is a clinically heterogeneous disease, with at least 5 different subtypes (4) and quite variable prognosis, even within a subtype. In spite of early detection programmes, unfortunately 20-30% of early stage cases will eventually experience recurrence and develop distant metastasis. However, currently, there is no acceptable method for monitoring patients who are lik........ Read more »

Martín-Sánchez E, Mendaza S, Ulazia-Garmendia A, Monreal-Santesteban I, Blanco-Luquin I, Córdoba A, Vicente-García F, Pérez-Janices N, Escors D, Megías D.... (2017) CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer. Oncotarget. PMID: 28178655  

Stefansson OA, Moran S, Gomez A, Sayols S, Arribas-Jorba C, Sandoval J, Hilmarsdottir H, Olafsdottir E, Tryggvadottir L, Jonasson JG.... (2015) A DNA methylation-based definition of biologically distinct breast cancer subtypes. Molecular oncology, 9(3), 555-68. PMID: 25468711  

He LH, Ma Q, Shi YH, Ge J, Zhao HM, Li SF, & Tong ZS. (2013) CHL1 is involved in human breast tumorigenesis and progression. Biochemical and biophysical research communications, 438(2), 433-8. PMID: 23906755  

Smith RA, Andrews K, Brooks D, DeSantis CE, Fedewa SA, Lortet-Tieulent J, Manassaram-Baptiste D, Brawley OW, & Wender RC. (2016) Cancer screening in the United States, 2016: A review of current American Cancer Society guidelines and current issues in cancer screening. CA: a cancer journal for clinicians, 66(2), 96-114. PMID: 26797525  

Feng W, Shen L, Wen S, Rosen DG, Jelinek J, Hu X, Huan S, Huang M, Liu J, Sahin AA.... (2007) Correlation between CpG methylation profiles and hormone receptor status in breast cancers. Breast cancer research : BCR, 9(4). PMID: 17764565  

Karsli-Ceppioglu S, Dagdemir A, Judes G, Ngollo M, Penault-Llorca F, Pajon A, Bignon YJ, & Bernard-Gallon D. (2014) Epigenetic mechanisms of breast cancer: an update of the current knowledge. Epigenomics, 6(6), 651-64. PMID: 25531258  

Widschwendter M, Siegmund KD, Müller HM, Fiegl H, Marth C, Müller-Holzner E, Jones PA, & Laird PW. (2004) Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer research, 64(11), 3807-13. PMID: 15172987  

Senchenko VN, Krasnov GS, Dmitriev AA, Kudryavtseva AV, Anedchenko EA, Braga EA, Pronina IV, Kondratieva TT, Ivanov SV, Zabarovsky ER.... (2011) Differential expression of CHL1 gene during development of major human cancers. PloS one, 6(3). PMID: 21408220  

  • March 8, 2017
  • 08:30 AM
  • 137 views

Epigenetic Predisposition to Radiation Fibrosis

by Christoph Weigel in EpiBeat

Radiotherapy is a highly efficient treatment for many cancers including breast cancer. Intraoperative radiotherapy (IORT), a relatively new type of radiation therapy, has proven successful as a curative treatment for early cancer stages. However, in spite of great improvements in dose delivery and imaging technology, unwanted exposure of healthy tissue to radiation cannot be fully avoided. The resulting late-onset toxicity due to the exposure of health tissue currently limits the usefulness of r........ Read more »

Weigel C, Veldwijk MR, Oakes CC, Seibold P, Slynko A, Liesenfeld DB, Rabionet M, Hanke SA, Wenz F, Sperk E.... (2016) Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. Nature communications, 10893. PMID: 26964756  

  • March 1, 2017
  • 08:00 AM
  • 109 views

Transient Imprinting of Genes in the Human Placenta

by Marta Sanchez Delgado in EpiBeat

When the fertilization occurs, the maternal and paternal pronuclei have thousands of opposite methylated regions. Most of this germline methylation are resolved during the postfertilization epigenetic reprogramming by active mechanism for the sperm-derived methylated regions and depending on DNA replication for the oocyte-derived ones. There is a subset of regions that are known to avoid this demethylation: the imprinted differentially methylated regions (DMRs). The imprinted DMRs are in general........ Read more »

Sanchez-Delgado M, Court F, Vidal E, Medrano J, Monteagudo-Sánchez A, Martin-Trujillo A, Tayama C, Iglesias-Platas I, Kondova I, Bontrop R.... (2016) Human Oocyte-Derived Methylation Differences Persist in the Placenta Revealing Widespread Transient Imprinting. PLoS genetics, 12(11). PMID: 27835649  

Smallwood SA, & Kelsey G. (2012) De novo DNA methylation: a germ cell perspective. Trends in genetics : TIG, 28(1), 33-42. PMID: 22019337  

Smith ZD, Chan MM, Humm KC, Karnik R, Mekhoubad S, Regev A, Eggan K, & Meissner A. (2014) DNA methylation dynamics of the human preimplantation embryo. Nature, 511(7511), 611-5. PMID: 25079558  

Barbaux S, Gascoin-Lachambre G, Buffat C, Monnier P, Mondon F, Tonanny MB, Pinard A, Auer J, Bessières B, Barlier A.... (2012) A genome-wide approach reveals novel imprinted genes expressed in the human placenta. Epigenetics, 7(9), 1079-90. PMID: 22894909  

Hanna CW, Peñaherrera MS, Saadeh H, Andrews S, McFadden DE, Kelsey G, & Robinson WP. (2016) Pervasive polymorphic imprinted methylation in the human placenta. Genome research, 26(6), 756-67. PMID: 26769960  

  • January 25, 2017
  • 08:00 AM
  • 208 views

Asthma & Histone Acetylation: an important epigenetic mechanism in allergic diseases

by Daniel Potaczek in EpiBeat

Epigenetic regulation is thought to be one of the most important mechanisms contributing to the development and clinical course of chronic immunological diseases like allergies and asthma. DNA methylation has been extensively studied in this context, which has not been a case of histone modifications such as histone acetylation or methylation.

Early epigenetic studies from our lab conducted in mouse models demonstrated a role for histone acetylation in mediating bacteria-induced protection ag........ Read more »

Harb H, Alashkar Alhamwe B, Garn H, Renz H, & Potaczek DP. (2016) Recent developments in epigenetics of pediatric asthma. Current opinion in pediatrics, 28(6), 754-763. PMID: 27662207  

Harb, H., Amarasekera, M., Ashley, S., Tulic, M., Pfefferle, P., Potaczek, D., Martino, D., Kesper, D., Prescott, S., & Renz, H. (2016) Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation. International Archives of Allergy and Immunology, 168(3), 173-181. DOI: 10.1159/000442158  

Harb, H., Raedler, D., Ballenberger, N., Böck, A., Kesper, D., Renz, H., & Schaub, B. (2015) Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation. Journal of Allergy and Clinical Immunology, 136(1), 200-202. DOI: 10.1016/j.jaci.2015.01.027  

Stefanowicz, D., Lee, J., Lee, K., Shaheen, F., Koo, H., Booth, S., Knight, D., & Hackett, T. (2015) Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects. Respiratory Research, 16(1). DOI: 10.1186/s12931-015-0254-y  

Harb, H., & Renz, H. (2015) Update on epigenetics in allergic disease. Journal of Allergy and Clinical Immunology, 135(1), 15-24. DOI: 10.1016/j.jaci.2014.11.009  

  • January 11, 2017
  • 08:00 AM
  • 334 views

DNA Methylation in the Placenta: accelerated aging in pregnancy complications

by Tina Bianco-Miotto in EpiBeat

The placenta is a unique organ as it is an extra-embryonic tissue primarily regulated by the fetal genome and shared between mother and fetus. However, it is a transient organ that is only needed throughout pregnancy and gestation and then is discarded after delivery. The essential role of the placenta in pregnancy is unquestionable but, surprisingly, as highlighted by the NIH NICHD Human Placenta Project (https://www.nichd.nih.gov/research/HPP/Pages/default.aspx), it is the human organ we know ........ Read more »

Bianco-Miotto T, Mayne BT, Buckberry S, Breen J, Rodriguez Lopez CM, & Roberts CT. (2016) Recent progress towards understanding the role of DNA methylation in human placental development. Reproduction (Cambridge, England), 152(1). PMID: 27026712  

Ehrlich M, Gama-Sosa MA, Huang LH, Midgett RM, Kuo KC, McCune RA, & Gehrke C. (1982) Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic acids research, 10(8), 2709-21. PMID: 7079182  

Fuke C, Shimabukuro M, Petronis A, Sugimoto J, Oda T, Miura K, Miyazaki T, Ogura C, Okazaki Y, & Jinno Y. (2004) Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study. Annals of human genetics, 68(Pt 3), 196-204. PMID: 15180700  

Schroeder DI, Blair JD, Lott P, Yu HO, Hong D, Crary F, Ashwood P, Walker C, Korf I, Robinson WP.... (2013) The human placenta methylome. Proceedings of the National Academy of Sciences of the United States of America, 110(15), 6037-42. PMID: 23530188  

Robinson WP, & Price EM. (2015) The human placental methylome. Cold Spring Harbor perspectives in medicine, 5(5). PMID: 25722473  

Marioni RE, Shah S, McRae AF, Chen BH, Colicino E, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR.... (2015) DNA methylation age of blood predicts all-cause mortality in later life. Genome biology, 25. PMID: 25633388  

  • December 7, 2016
  • 08:00 AM
  • 374 views

MicroRNA expression is regulated by DNA methylation: a complex cascade of gene regulation events

by Barbara Banelli in EpiBeat

MicroRNAs (miRNAs) are non-coding RNAs, roughly 22 nucleotides in size that are central and negative regulators of gene expression. They exert their functions through base-pairing with the 3’UTR of mRNAs and block expression at the transcriptional and post-transcriptional levels, depending on the perfect or imperfect match in sequences between miRNAs and their target genes. miRNAs are central nodes in a variety of biological processes like cell proliferation, apoptosis, migration and dif........ Read more »

Parodi F, Carosio R, Ragusa M, Di Pietro C, Maugeri M, Barbagallo D, Sallustio F, Allemanni G, Pistillo MP, Casciano I.... (2016) Epigenetic dysregulation in neuroblastoma: A tale of miRNAs and DNA methylation. Biochimica et biophysica acta, 1859(12), 1502-1514. PMID: 27751904  

  • November 30, 2016
  • 07:00 AM
  • 323 views

A Better Model System for Ovarian Cancer: Patient-derived tumor xenografts (PDXs) are suitable for epigenetic methylome-based cancer research

by Tushar Tomar in EpiBeat

Ovarian cancer is the most lethal gynecologic malignancy. After epigenomic analysis of patient tumors, aberrant DNA methylation patterns are universally observed in the most abundant histological subtype of ovarian cancer, high-grade serous ovarian cancer (HGSOC). These epigenetic modifications like DNA methylation are known to frequently affect gene regulation involved in cancer-related processes. Since epigenetic alterations are reversible in nature, these changes have emerged as attractive ta........ Read more »

Alkema NG, Wisman GB, van der Zee AG, van Vugt MA, & de Jong S. (2016) Studying platinum sensitivity and resistance in high-grade serous ovarian cancer: Different models for different questions. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 55-69. PMID: 26830315  

Hidalgo M, Amant F, Biankin AV, Budinská E, Byrne AT, Caldas C, Clarke RB, de Jong S, Jonkers J, Mælandsmo GM.... (2014) Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer discovery, 4(9), 998-1013. PMID: 25185190  

  • November 23, 2016
  • 07:00 AM
  • 349 views

Hypertriacylglycerolaemia: Genetic and epigenetic factors jointly regulate circulating triacylglycerol levels

by Iris Oliva Rodriguez in EpiBeat

Apolipoprotein A5 gene (APOA5) is one of the genes implicated in contributing to a predisposition for hypertriacylglycerolaemia (HTG), a complex polygenic pathology that is highly influenced by environment. Hypertriacylglycerolaemia is characterized by having high circulating triacylglycerol levels and is a significant risk factor for cardiovascular disease and atherosclerosis. This genetic predisposition has an inherited component (based on polymorphisms) as well as an acquired component regu........ Read more »

Oliva, I., Guardiola, M., Vallve, J., Ibarretxe, D., Plana, N., Masana, L., Monk, D., & Ribalta, J. (2016) APOA5 genetic and epigenetic variability jointly regulate circulating triacylglycerol levels. Clinical Science, 130(22), 2053-2059. DOI: 10.1042/CS20160433  

  • November 17, 2016
  • 11:00 AM
  • 359 views

DNA damage and repair permanently change the chromatin and DNA: Mechanisms of DNA methylation polymorphism

by Enrico Avvedimento in EpiBeat

DNA methylation is a biological clock that ticks with age, and numerous studies have been able to construct age-prediction models based on methylation status. However in somatic cells, DNA methylation is highly polymorphic – though this is not always appreciated in genome wide studies because coverage is often limited and variants below 10% usually escape detection. In an effort to clarify the origin of somatic DNA methylation heterogeneity and the impact it has on chromatin domains and ge........ Read more »

Cuozzo, C., Porcellini, A., Angrisano, T., Morano, A., Lee, B., Pardo, A., Messina, S., Iuliano, R., Fusco, A., Santillo, M.... (2007) DNA Damage, Homology-Directed Repair, and DNA Methylation. PLoS Genetics, 3(7). DOI: 10.1371/journal.pgen.0030110  

Morano, A., Angrisano, T., Russo, G., Landi, R., Pezone, A., Bartollino, S., Zuchegna, C., Babbio, F., Bonapace, I., Allen, B.... (2013) Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene. Nucleic Acids Research, 42(2), 804-821. DOI: 10.1093/nar/gkt920  

Landan, G., Cohen, N., Mukamel, Z., Bar, A., Molchadsky, A., Brosh, R., Horn-Saban, S., Zalcenstein, D., Goldfinger, N., Zundelevich, A.... (2012) Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues. Nature Genetics, 44(11), 1207-1214. DOI: 10.1038/ng.2442  

  • November 2, 2016
  • 08:00 AM
  • 208 views

Estrogen, Memory, & Aging: DNA methylation of the ERα promoter contributes to transcriptional differences in age across the hippocampus

by Lara Ianov in EpiBeat

Estradiol (E2) influences a number of processes that are important for maintaining healthy brain function, including memory. The ability of E2 to protect the brain and enhance or maintain memory function depends on the interaction of E2 with different estrogen receptors.1 In particular, the expression of estrogen receptor alpha (ERα) has been linked to synaptic plasticity, inflammation, and neuroprotection.2-5 Thus, it may be important that expression of ERα in the hippocampus, a bra........ Read more »

Bean LA, Ianov L, & Foster TC. (2014) Estrogen receptors, the hippocampus, and memory. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 20(5), 534-45. PMID: 24510074  

Adams MM, Fink SE, Shah RA, Janssen WG, Hayashi S, Milner TA, McEwen BS, & Morrison JH. (2002) Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(9), 3608-14. PMID: 11978836  

Benedusi V, Meda C, Della Torre S, Monteleone G, Vegeto E, & Maggi A. (2012) A lack of ovarian function increases neuroinflammation in aged mice. Endocrinology, 153(6), 2777-88. PMID: 22492304  

Merchenthaler I, Dellovade TL, & Shughrue PJ. (2003) Neuroprotection by estrogen in animal models of global and focal ischemia. Annals of the New York Academy of Sciences, 89-100. PMID: 14993043  

Zhang QG, Raz L, Wang R, Han D, De Sevilla L, Yang F, Vadlamudi RK, & Brann DW. (2009) Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(44), 13823-36. PMID: 19889994  

Bean LA, Kumar A, Rani A, Guidi M, Rosario AM, Cruz PE, Golde TE, & Foster TC. (2015) Re-Opening the Critical Window for Estrogen Therapy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(49), 16077-93. PMID: 26658861  

Han X, Aenlle KK, Bean LA, Rani A, Semple-Rowland SL, Kumar A, & Foster TC. (2013) Role of estrogen receptor α and β in preserving hippocampal function during aging. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(6), 2671-83. PMID: 23392694  

  • September 28, 2016
  • 11:10 AM
  • 388 views

When the writing is wrong: PRMT5 histone arginine methylation promotes invasivity and metastasis in a range of human cancers

by David Schecter in EpiBeat

Cancer metastasis occurs when cancer cells leave a primary tumor and invade other tissues. Generally, this leads to a poor prognosis for patients. Underlying epigenetic mechanisms of tumor progression are poorly understood but are of great interest for developing new approaches of treatment in the clinic. Cancer etiology is highly correlated with alterations in the histone code1-5 and protein methyltransferases are frequently dysregulated in cancer, implicating them as compelling novel targets f........ Read more »

Stopa N, Krebs JE, & Shechter D. (2015) The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond. Cellular and molecular life sciences : CMLS, 72(11), 2041-59. PMID: 25662273  

Sebova K, & Fridrichova I. (2010) Epigenetic tools in potential anticancer therapy. Anti-cancer drugs, 21(6), 565-77. PMID: 20436342  

Yang, Y., & Bedford, M. (2012) Protein arginine methyltransferases and cancer. Nature Reviews Cancer, 13(1), 37-50. DOI: 10.1038/nrc3409  

Greenblatt SM, Liu F, & Nimer SD. (2016) Arginine methyltransferases in normal and malignant hematopoiesis. Experimental hematology, 44(6), 435-41. PMID: 27026282  

Chan-Penebre E, Kuplast KG, Majer CR, Boriack-Sjodin PA, Wigle TJ, Johnston LD, Rioux N, Munchhof MJ, Jin L, Jacques SL.... (2015) A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nature chemical biology, 11(6), 432-7. PMID: 25915199  

Liu F, Cheng G, Hamard PJ, Greenblatt S, Wang L, Man N, Perna F, Xu H, Tadi M, Luciani L.... (2015) Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. The Journal of clinical investigation, 125(9), 3532-44. PMID: 26258414  

Ikushima H, & Miyazono K. (2010) TGFbeta signalling: a complex web in cancer progression. Nature reviews. Cancer, 10(6), 415-24. PMID: 20495575  

Lamouille, S., Xu, J., & Derynck, R. (2014) Molecular mechanisms of epithelial–mesenchymal transition. Nature Reviews Molecular Cell Biology, 15(3), 178-196. DOI: 10.1038/nrm3758  

  • September 14, 2016
  • 08:00 AM
  • 461 views

5-Formlycytosine (5fC): A new base?

by Eliza Bacon in EpiBeat

DNA methylation and hydroxymethylation are well-established key players in gene regulation. Although many would agree that 5hmC also plays a critical role, there is still some debate over whether it serves a functional role, or is merely an artifact of DNA de-methylation. Even still, other intermediates of de-methylation are actively being investigated. In a recent paper by Iuilaro et al. 2016, a group of scientists argue that 5-formlycytosine (5fC), an intermediate of DNA de-methylation, is a s........ Read more »

Iurlaro M, McInroy GR, Burgess HE, Dean W, Raiber EA, Bachman M, Beraldi D, Balasubramanian S, & Reik W. (2016) In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine. Genome biology, 17(1), 141. PMID: 27356509  

  • August 24, 2016
  • 07:30 AM
  • 519 views

Epigenetics of Early Pregnancy Loss: Hypomethylation and Genetic Instability May Contribute to Decreased Implantation Potential of Monosomy Blastocysts

by Blair McCallie in EpiBeat

Aneuploidy is the leading cause of miscarriage, stillbirth, and congenital birth defects and occurs as a result of errors during meiotic or mitotic cell division.1 As a woman ages, the probability of an aneuploid conception significantly rises, to roughly 50% by the age of 40.2 Only a fraction of full aneuploidies, primarily trisomies, will develop past the first trimester. This is in contrast to monosomies that almost never implant or result in an ongoing pregnancy. DNA methylation is an epi........ Read more »

  • July 27, 2016
  • 09:30 AM
  • 573 views

HPV Human Papillomavirus Leads to Dysregulation of Immune Responses Through Epigenetic Mechanisms

by Louis Cicchini in EpiBeat

Human papillomaviruses (HPV) are a diverse group of small double-stranded DNA viruses with specific mucosal or cutaneous tropisms. It is estimated that up to 80% of sexually active individuals will become infected with HPV sometime in their lifetime, making HPV the most prevalent sexually transmitted infection. HPVs can be further divided into high- and low-risk genotypes, based on their oncogenic potential. High-risk HPVs are implicated as causal in nearly 100% of cervical cancers, approximatel........ Read more »

Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A.... (2011) The mutational landscape of head and neck squamous cell carcinoma. Science (New York, N.Y.), 333(6046), 1157-60. PMID: 21798893  

Burgers WA, Blanchon L, Pradhan S, de Launoit Y, Kouzarides T, & Fuks F. (2007) Viral oncoproteins target the DNA methyltransferases. Oncogene, 26(11), 1650-5. PMID: 16983344  

Schlecht NF, Kulaga S, Robitaille J, Ferreira S, Santos M, Miyamura RA, Duarte-Franco E, Rohan TE, Ferenczy A, Villa LL.... (2001) Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. JAMA, 286(24), 3106-14. PMID: 11754676  

  • July 20, 2016
  • 08:30 AM
  • 560 views

The “neighborhood effect” in chromatin biology: TET proteins-mediated DNA demethylation reconfigures the “histone code” at CpG islands

by Li Tan in EpiBeat

A nucleosome is constituted by positively charged histone proteins and negatively charged DNA. Methylation as well as other covalent modifications on DNA and histones ( together also called epigenetic modifications or marks) play important roles in the regulation of chromatin structure and function. TET (Ten-Eleven Translocation) proteins were identified as 5mC oxidases which not only generate new 5mC oxidative derivates (5hmC, 5caC and 5fC) but also initiate active or passive DNA demethylation1........ Read more »

Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L.... (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (New York, N.Y.), 324(5929), 930-5. PMID: 19372391  

He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L.... (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (New York, N.Y.), 333(6047), 1303-7. PMID: 21817016  

Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, & Zhang Y. (2011) Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (New York, N.Y.), 333(6047), 1300-3. PMID: 21778364  

Easwaran H, Johnstone SE, Van Neste L, Ohm J, Mosbruger T, Wang Q, Aryee MJ, Joyce P, Ahuja N, Weisenberger D.... (2012) A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome research, 22(5), 837-49. PMID: 22391556  

Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q.... (2012) Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell, 150(6), 1135-46. PMID: 22980977  

  • July 13, 2016
  • 07:30 AM
  • 581 views

Plenty of Fish in the Sea but Only Two Kinds of Brains: Epigenetic Sex differences in Zebrafish Brain

by Aniruddha Chatterjee in EpiBeat

Phenotypic differences between males and females of a species are referred to as sexual dimorphism. Sexual dimorphism manifests not only in morphological traits, but also in physiological and behavioural traits. In organisms that do not have sex chromosomes, males and females are both derived from a nearly identical genome. Such is the case in zebrafish. Despite being such an important model for biological research, the mechanism of sex determination still remains a mystery. Many believe environ........ Read more »

Chatterjee A, Ozaki Y, Stockwell PA, Horsfield JA, Morison IM, & Nakagawa S. (2013) Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing. Epigenetics, 8(9), 979-89. PMID: 23975027  

Chatterjee A, Stockwell PA, Horsfield JA, Morison IM, & Nakagawa S. (2014) Base-resolution DNA methylation landscape of zebrafish brain and liver. Genomics data, 342-4. PMID: 26484126  

Gagnidze K, Weil ZM, & Pfaff DW. (2010) Histone modifications proposed to regulate sexual differentiation of brain and behavior. BioEssays : news and reviews in molecular, cellular and developmental biology, 32(11), 932-9. PMID: 20836091  

  • July 6, 2016
  • 07:30 AM
  • 585 views

Ancestral alcohol consumption may influence your drinking behavior and responses to stress

by Gregg E. Homanics in EpiBeat

Mice born to alcohol exposed fathers were resistant to stress-induced drinking. Read more on today's EpiBeat!... Read more »

  • October 29, 2014
  • 12:00 PM
  • 816 views

Dopamine signaling leads to loss of polycomb repression and aberrant gene activation in experimental parkinsonism

by EpiBeat in EpiBeat

Parkinson’s disease (PD) is the second most frequent neurodegenerative disease, affecting 1-2% of the population over 55 years of age. The main pathological feature of PD is the progressive death of neurons located in the midbrain that produce the neurotransmitter dopamine.  These neurons modulate the activity of a collection of ...
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Birkmayer W, & Hornykiewicz O. (1998) The effect of l-3,4-dihydroxyphenylalanine (. Parkinsonism , 4(2), 59-60. PMID: 18591089  

Feyder M, Södersten E, Santini E, Vialou V, LaPlant Q, Watts EL, Spigolon G, Hansen K, Caboche J, Nestler EJ.... (2014) A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression. Biological psychiatry. PMID: 25193242  

Santini E, Valjent E, Usiello A, Carta M, Borgkvist A, Girault JA, Hervé D, Greengard P, & Fisone G. (2007) Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(26), 6995-7005. PMID: 17596448  

Di Croce, L., & Helin, K. (2013) Transcriptional regulation by Polycomb group proteins. Nature Structural , 20(10), 1147-1155. DOI: 10.1038/nsmb.2669  

  • October 22, 2014
  • 12:00 PM
  • 811 views

Imprinting, epigenetic markers and assisted reproductive technologies (ARTs)

by EpiBeat in EpiBeat

Epigenetics refers to changes in gene regulation that are do not related to changes in the primary sequence of DNA. It can be reversible and heritable throughout cell division, and its regulation is characterized by several modifications, such as DNA methylation and post-translational changes in the histone proteins. In addition, ...
The post Imprinting, epigenetic markers and assisted reproductive technologies (ARTs) appeared first on EpiBeat.
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Carvalho JO, Michalczechen-Lacerda VA, Sartori R, Rodrigues FC, Bravim O, Franco MM, & Dode MA. (2012) The methylation patterns of the IGF2 and IGF2R genes in bovine spermatozoa are not affected by flow-cytometric sex sorting. Molecular reproduction and development, 79(2), 77-84. PMID: 22128039  

  • October 15, 2014
  • 11:00 AM
  • 818 views

Artificial Transcription Factors – A new class of epigenetic drug

by EpiBeat in EpiBeat

Aberrant epigenetic status resulting in dysregulation of gene expression is a hallmark of many cancers and other diseases. In the last decade, countless time and energy has been spent in efforts to develop drugs targeting DNA methylation and histone modifications. To date however, none of these epigenetic drugs are sequence ...
The post Artificial Transcription Factors – A new class of epigenetic drug appeared first on EpiBeat.
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