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EpiBeat is an epigenetics resource and community for you to stay up-to-date and join the conversation on the rapidly expanding field of epigenetics. Here, you can read and discuss summaries of some of our favorite new epigenetic publications, each presented succinctly so you can keep current with the literature without having to read every paper in detail. It’s a simple way to keep with the beat in epigenetics! We also make it easy to learn more about epigenetics, get tips & tricks from the industry, ask questions about your research and get answers from other scientists. EpiBeat was created for scientists by scientists and is hosted by Zymo Research, The Epigenetics Company.
Cancer metastasis occurs when cancer cells leave a primary tumor and invade other tissues. Generally, this leads to a poor prognosis for patients. Underlying epigenetic mechanisms of tumor progression are poorly understood but are of great interest for developing new approaches of treatment in the clinic. Cancer etiology is highly correlated with alterations in the histone code1-5 and protein methyltransferases are frequently dysregulated in cancer, implicating them as compelling novel targets f........ Read more »
Chen H, Lorton B, Gupta V, & Shechter D. (2016) A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression. Oncogene. PMID: 27270440
Chi P, Allis CD, & Wang GG. (2010) Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nature reviews. Cancer, 10(7), 457-69. PMID: 20574448
Stopa N, Krebs JE, & Shechter D. (2015) The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond. Cellular and molecular life sciences : CMLS, 72(11), 2041-59. PMID: 25662273
Cha B, & Jho EH. (2012) Protein arginine methyltransferases (PRMTs) as therapeutic targets. Expert opinion on therapeutic targets, 16(7), 651-64. PMID: 22621686
Yang XJ, & Seto E. (2008) Lysine acetylation: codified crosstalk with other posttranslational modifications. Molecular cell, 31(4), 449-61. PMID: 18722172
Greenblatt SM, Liu F, & Nimer SD. (2016) Arginine methyltransferases in normal and malignant hematopoiesis. Experimental hematology, 44(6), 435-41. PMID: 27026282
Wilczek C, Chitta R, Woo E, Shabanowitz J, Chait BT, Hunt DF, & Shechter D. (2011) Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs. The Journal of biological chemistry, 286(49), 42221-31. PMID: 22009756
Ho MC, Wilczek C, Bonanno JB, Xing L, Seznec J, Matsui T, Carter LG, Onikubo T, Kumar PR, Chan MK.... (2013) Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity. PloS one, 8(2). PMID: 23451136
Burgos ES, Wilczek C, Onikubo T, Bonanno JB, Jansong J, Reimer U, & Shechter D. (2015) Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase. The Journal of biological chemistry, 290(15), 9674-89. PMID: 25713080
Chan-Penebre E, Kuplast KG, Majer CR, Boriack-Sjodin PA, Wigle TJ, Johnston LD, Rioux N, Munchhof MJ, Jin L, Jacques SL.... (2015) A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nature chemical biology, 11(6), 432-7. PMID: 25915199
Liu F, Cheng G, Hamard PJ, Greenblatt S, Wang L, Man N, Perna F, Xu H, Tadi M, Luciani L.... (2015) Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. The Journal of clinical investigation, 125(9), 3532-44. PMID: 26258414
Ikushima H, & Miyazono K. (2010) TGFbeta signalling: a complex web in cancer progression. Nature reviews. Cancer, 10(6), 415-24. PMID: 20495575
Lamouille, S., Xu, J., & Derynck, R. (2014) Molecular mechanisms of epithelial–mesenchymal transition. Nature Reviews Molecular Cell Biology, 15(3), 178-196. DOI: 10.1038/nrm3758
DNA methylation and hydroxymethylation are well-established key players in gene regulation. Although many would agree that 5hmC also plays a critical role, there is still some debate over whether it serves a functional role, or is merely an artifact of DNA de-methylation. Even still, other intermediates of de-methylation are actively being investigated. In a recent paper by Iuilaro et al. 2016, a group of scientists argue that 5-formlycytosine (5fC), an intermediate of DNA de-methylation, is a s........ Read more »
Iurlaro M, McInroy GR, Burgess HE, Dean W, Raiber EA, Bachman M, Beraldi D, Balasubramanian S, & Reik W. (2016) In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine. Genome biology, 17(1), 141. PMID: 27356509
Aneuploidy is the leading cause of miscarriage, stillbirth, and congenital birth defects and occurs as a result of errors during meiotic or mitotic cell division.1 As a woman ages, the probability of an aneuploid conception significantly rises, to roughly 50% by the age of 40.2 Only a fraction of full aneuploidies, primarily trisomies, will develop past the first trimester. This is in contrast to monosomies that almost never implant or result in an ongoing pregnancy. DNA methylation is an epi........ Read more »
McCallie BR, Parks JC, Patton AL, Griffin DK, Schoolcraft WB, & Katz-Jaffe MG. (2016) Hypomethylation and Genetic Instability in Monosomy Blastocysts May Contribute to Decreased Implantation Potential. PloS one, 11(7). PMID: 27434648
Hassold T, Hall H, & Hunt P. (2007) The origin of human aneuploidy: where we have been, where we are going. Human molecular genetics. PMID: 17911163
Grewal, S. (2003) Heterochromatin and Epigenetic Control of Gene Expression. Science, 301(5634), 798-802. DOI: 10.1126/science.1086887
Messerschmidt DM, Knowles BB, & Solter D. (2014) DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos. Genes , 28(8), 812-28. PMID: 24736841
Kahlem, P. (2004) Transcript Level Alterations Reflect Gene Dosage Effects Across Multiple Tissues in a Mouse Model of Down Syndrome. Genome Research, 14(7), 1258-1267. DOI: 10.1101/gr.1951304
Human papillomaviruses (HPV) are a diverse group of small double-stranded DNA viruses with specific mucosal or cutaneous tropisms. It is estimated that up to 80% of sexually active individuals will become infected with HPV sometime in their lifetime, making HPV the most prevalent sexually transmitted infection. HPVs can be further divided into high- and low-risk genotypes, based on their oncogenic potential. High-risk HPVs are implicated as causal in nearly 100% of cervical cancers, approximatel........ Read more »
Cicchini L, Westrich JA, Xu T, Vermeer DW, Berger JN, Clambey ET, Lee D, Song JI, Lambert PF, Greer RO.... (2016) Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14. mBio, 7(3). PMID: 27143385
Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A.... (2011) The mutational landscape of head and neck squamous cell carcinoma. Science (New York, N.Y.), 333(6046), 1157-60. PMID: 21798893
Anayannis NV, Schlecht NF, & Belbin TJ. (2015) Epigenetic Mechanisms of Human Papillomavirus-Associated Head and Neck Cancer. Archives of pathology , 139(11), 1373-8. PMID: 25978766
Cancer Genome Atlas Network. (2015) Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature, 517(7536), 576-82. PMID: 25631445
Burgers WA, Blanchon L, Pradhan S, de Launoit Y, Kouzarides T, & Fuks F. (2007) Viral oncoproteins target the DNA methyltransferases. Oncogene, 26(11), 1650-5. PMID: 16983344
Schlecht NF, Kulaga S, Robitaille J, Ferreira S, Santos M, Miyamura RA, Duarte-Franco E, Rohan TE, Ferenczy A, Villa LL.... (2001) Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. JAMA, 286(24), 3106-14. PMID: 11754676
A nucleosome is constituted by positively charged histone proteins and negatively charged DNA. Methylation as well as other covalent modifications on DNA and histones ( together also called epigenetic modifications or marks) play important roles in the regulation of chromatin structure and function. TET (Ten-Eleven Translocation) proteins were identified as 5mC oxidases which not only generate new 5mC oxidative derivates (5hmC, 5caC and 5fC) but also initiate active or passive DNA demethylation1........ Read more »
Kong L, Tan L, Lv R, Shi Z, Xiong L, Wu F, Rabidou K, Smith M, He C, Zhang L.... (2016) A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands. Nucleic acids research. PMID: 27288448
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L.... (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (New York, N.Y.), 324(5929), 930-5. PMID: 19372391
He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L.... (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (New York, N.Y.), 333(6047), 1303-7. PMID: 21817016
Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, & Zhang Y. (2011) Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (New York, N.Y.), 333(6047), 1300-3. PMID: 21778364
Zhang, H., Zhang, X., Clark, E., Mulcahey, M., Huang, S., & Shi, Y. (2010) TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine. Cell Research, 20(12), 1390-1393. DOI: 10.1038/cr.2010.156
Ehrlich M. (2002) DNA methylation in cancer: too much, but also too little. Oncogene, 21(35), 5400-13. PMID: 12154403
Cedar H, & Bergman Y. (2009) Linking DNA methylation and histone modification: patterns and paradigms. Nature reviews. Genetics, 10(5), 295-304. PMID: 19308066
Easwaran H, Johnstone SE, Van Neste L, Ohm J, Mosbruger T, Wang Q, Aryee MJ, Joyce P, Ahuja N, Weisenberger D.... (2012) A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome research, 22(5), 837-49. PMID: 22391556
Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q.... (2012) Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell, 150(6), 1135-46. PMID: 22980977
Tan L, & Shi YG. (2012) Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development (Cambridge, England), 139(11), 1895-902. PMID: 22569552
Phenotypic differences between males and females of a species are referred to as sexual dimorphism. Sexual dimorphism manifests not only in morphological traits, but also in physiological and behavioural traits. In organisms that do not have sex chromosomes, males and females are both derived from a nearly identical genome. Such is the case in zebrafish. Despite being such an important model for biological research, the mechanism of sex determination still remains a mystery. Many believe environ........ Read more »
Chatterjee, A., Lagisz, M., Rodger, E., Zhen, L., Stockwell, P., Duncan, E., Horsfield, J., Jeyakani, J., Mathavan, S., Ozaki, Y.... (2016) Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended ‘male sex drive’ hypothesis. Gene. DOI: 10.1016/j.gene.2016.05.042
Connallon T, & Knowles LL. (2005) Intergenomic conflict revealed by patterns of sex-biased gene expression. Trends in genetics : TIG, 21(9), 495-9. PMID: 16039005
Ellegren, H., & Parsch, J. (2007) The evolution of sex-biased genes and sex-biased gene expression. Nature Reviews Genetics, 8(9), 689-698. DOI: 10.1038/nrg2167
Chatterjee A, Ozaki Y, Stockwell PA, Horsfield JA, Morison IM, & Nakagawa S. (2013) Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing. Epigenetics, 8(9), 979-89. PMID: 23975027
Chatterjee A, Stockwell PA, Horsfield JA, Morison IM, & Nakagawa S. (2014) Base-resolution DNA methylation landscape of zebrafish brain and liver. Genomics data, 342-4. PMID: 26484126
Chatterjee A, Leichter AL, Fan V, Tsai P, Purcell RV, Sullivan MJ, & Eccles MR. (2015) Erratum: A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients. Scientific reports, 13505. PMID: 26328756
Gagnidze K, Weil ZM, & Pfaff DW. (2010) Histone modifications proposed to regulate sexual differentiation of brain and behavior. BioEssays : news and reviews in molecular, cellular and developmental biology, 32(11), 932-9. PMID: 20836091
Mice born to alcohol exposed fathers were resistant to stress-induced drinking. Read more on today's EpiBeat!... Read more »
Rompala GR, Finegersh A, & Homanics GE. (2016) Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice. Alcohol (Fayetteville, N.Y.), 19-25. PMID: 27286933
Parkinson’s disease (PD) is the second most frequent neurodegenerative disease, affecting 1-2% of the population over 55 years of age. The main pathological feature of PD is the progressive death of neurons located in the midbrain that produce the neurotransmitter dopamine. These neurons modulate the activity of a collection of ...
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Södersten E, Feyder M, Lerdrup M, Gomes AL, Kryh H, Spigolon G, Caboche J, Fisone G, & Hansen K. (2014) Dopamine signaling leads to loss of polycomb repression and aberrant gene activation in experimental parkinsonism. PLoS genetics, 10(9). PMID: 25254549
Obeso, J., Olanow, C., & Nutt, J. (2000) Levodopa motor complications in Parkinson's disease. Trends in Neurosciences. DOI: 10.1016/S1471-1931(00)00031-8
Feyder M, Bonito-Oliva A, & Fisone G. (2011) L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission. Frontiers in behavioral neuroscience, 71. PMID: 22028687
Feyder M, Södersten E, Santini E, Vialou V, LaPlant Q, Watts EL, Spigolon G, Hansen K, Caboche J, Nestler EJ.... (2014) A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression. Biological psychiatry. PMID: 25193242
Santini E, Valjent E, Usiello A, Carta M, Borgkvist A, Girault JA, Hervé D, Greengard P, & Fisone G. (2007) Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(26), 6995-7005. PMID: 17596448
Di Croce, L., & Helin, K. (2013) Transcriptional regulation by Polycomb group proteins. Nature Structural , 20(10), 1147-1155. DOI: 10.1038/nsmb.2669
Gehani SS, Agrawal-Singh S, Dietrich N, Christophersen NS, Helin K, & Hansen K. (2010) Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Molecular cell, 39(6), 886-900. PMID: 20864036
Epigenetics refers to changes in gene regulation that are do not related to changes in the primary sequence of DNA. It can be reversible and heritable throughout cell division, and its regulation is characterized by several modifications, such as DNA methylation and post-translational changes in the histone proteins. In addition, ...
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Franco MM, Prickett AR, & Oakey RJ. (2014) The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting, Development, and Reproduction. Biology of reproduction. PMID: 25297545
Franco MM, Fagundes NS, Michalczechen-Lacerda VA, Caixeta ES, de Castro Rodrigues F, Machado GM, Ferreira AR, & Dode MA. (2014) Characterisation of the methylation pattern in the intragenic CpG island of the IGF2 gene in Bos taurus indicus cumulus cells during in vitro maturation. Journal of assisted reproduction and genetics, 31(1), 115-20. PMID: 24174298
Carvalho JO, Michalczechen-Lacerda VA, Sartori R, Rodrigues FC, Bravim O, Franco MM, & Dode MA. (2012) The methylation patterns of the IGF2 and IGF2R genes in bovine spermatozoa are not affected by flow-cytometric sex sorting. Molecular reproduction and development, 79(2), 77-84. PMID: 22128039
Fagundes NS, Michalczechen-Lacerda VA, Caixeta ES, Machado GM, Rodrigues FC, Melo EO, Dode MA, & Franco MM. (2011) Methylation status in the intragenic differentially methylated region of the IGF2 locus in Bos taurus indicus oocytes with different developmental competencies. Molecular human reproduction, 17(2), 85-91. PMID: 20833870
Aberrant epigenetic status resulting in dysregulation of gene expression is a hallmark of many cancers and other diseases. In the last decade, countless time and energy has been spent in efforts to develop drugs targeting DNA methylation and histone modifications. To date however, none of these epigenetic drugs are sequence ...
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Grimmer MR, Stolzenburg S, Ford E, Lister R, Blancafort P, & Farnham PJ. (2014) Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation. Nucleic acids research, 42(16), 10856-68. PMID: 25122745
More than 35% of the U.S. population is considered clinically obese (body mass index of > 30), while 68% of the U.S. is considered overweight (body mass index of > 25) 1. Obesity is known to have adverse health effects, impacting the risk and prognosis for a number of diseases, ...
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Ogden CL, Carroll MD, Kit BK, & Flegal KM. (2014) Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA, 311(8), 806-14. PMID: 24570244
Hu FB. (2011) Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes care, 34(6), 1249-57. PMID: 21617109
McCormick DP, Sarpong K, Jordan L, Ray LA, & Jain S. (2010) Infant obesity: are we ready to make this diagnosis?. The Journal of pediatrics, 157(1), 15-9. PMID: 20338575
Klimentidis, Y., Beasley, T., Lin, H., Murati, G., Glass, G., Guyton, M., Newton, W., Jorgensen, M., Heymsfield, S., Kemnitz, J.... (2010) Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemics. Proceedings of the Royal Society B: Biological Sciences, 278(1712), 1626-1632. DOI: 10.1098/rspb.2010.1890
Milagro FI, Mansego ML, De Miguel C, & Martínez JA. (2013) Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives. Molecular aspects of medicine, 34(4), 782-812. PMID: 22771541
Prior LJ, & Armitage JA. (2009) Neonatal overfeeding leads to developmental programming of adult obesity: you are what you ate. The Journal of physiology, 587(Pt 11), 2419. PMID: 19483248
Grün F, & Blumberg B. (2007) Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis. Reviews in endocrine , 8(2), 161-71. PMID: 17657605
Grün F, & Blumberg B. (2006) Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology, 147(6 Suppl). PMID: 16690801
Janesick A, & Blumberg B. (2011) Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity. Birth defects research. Part C, Embryo today : reviews, 93(1), 34-50. PMID: 21425440
Snedeker SM, & Hay AG. (2012) Do interactions between gut ecology and environmental chemicals contribute to obesity and diabetes?. Environmental health perspectives, 120(3), 332-9. PMID: 22042266
Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, Aubert ML, & Hüppi PS. (2009) Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environmental health perspectives, 117(10), 1549-55. PMID: 20019905
Chamorro-García R, Sahu M, Abbey RJ, Laude J, Pham N, & Blumberg B. (2013) Transgenerational inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis elicited by prenatal exposure to the obesogen tributyltin in mice. Environmental health perspectives, 121(3), 359-66. PMID: 23322813
Manikkam M, Tracey R, Guerrero-Bosagna C, & Skinner MK. (2013) Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. PloS one, 8(1). PMID: 23359474
Grün F, Watanabe H, Zamanian Z, Maeda L, Arima K, Cubacha R, Gardiner DM, Kanno J, Iguchi T, & Blumberg B. (2006) Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Molecular endocrinology (Baltimore, Md.), 20(9), 2141-55. PMID: 16613991
Skinner MK, Manikkam M, Tracey R, Guerrero-Bosagna C, Haque M, & Nilsson EE. (2013) Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity. BMC medicine, 228. PMID: 24228800
Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, Rodford J, Slater-Jefferies JL, Garratt E, Crozier SR.... (2011) Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes, 60(5), 1528-34. PMID: 21471513
Herskind AM, McGue M, Iachine IA, Holm N, Sørensen TI, Harvald B, & Vaupel JW. (1996) Untangling genetic influences on smoking, body mass index and longevity: a multivariate study of 2464 Danish twins followed for 28 years. Human genetics, 98(4), 467-75. PMID: 8792824
Schuster-Böckler, B., & Lehner, B. (2012) Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature, 488(7412), 504-507. DOI: 10.1038/nature11273
Atherosclerosis is an inflammatory disease of the arterial walls, and is the major cause of heart attack and stroke. Atherosclerosis is localized to curves and branches in the vasculature where disturbed blood flow (d-flow) is able to alter gene expression and induce endothelial cell (EC) dysfunction. Our lab’s work focuses on the mechanism by which ...
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Dunn J, Qiu H, Kim S, Jjingo D, Hoffman R, Kim CW, Jang I, Son DJ, Kim D, Pan C.... (2014) Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. The Journal of clinical investigation. PMID: 24865430
Nam D, Ni CW, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison D, Giddens D, & Jo H. (2009) Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. American journal of physiology. Heart and circulatory physiology, 297(4). PMID: 19684185
Ni CW, Qiu H, Rezvan A, Kwon K, Nam D, Son DJ, Visvader JE, & Jo H. (2010) Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow. Blood, 116(15). PMID: 20551377
Gerhard A. Coetzee, Wange Lu, Peggy Farnham USC Genome-wide association studies (GWAS) have revealed numerous single-nucleotide polymorphisms (SNPs) where allelic frequencies differ between cases and controls of many complex diseases (NHGRI GWA Catalog). In the last decade 6,696 genetic associations of 598 traits have been reported in 16,770 papers (up to 2013). Despite these impressive ...
The post SNP-SNP here, SNP-SNP there, everywhere a SNP-SNP, old McDonald had a GWAS…… appeared first o........ Read more »
Hazelett DJ, Rhie SK, Gaddis M, Yan C, Lakeland DL, Coetzee SG, Ellipse/GAME-ON consortium, Practical consortium, Henderson BE, Noushmehr H.... (2014) Comprehensive functional annotation of 77 prostate cancer risk loci. PLoS genetics, 10(1). PMID: 24497837
Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S.... (2013) Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature genetics, 45(4), 385. PMID: 23535732
Coetzee SG, Rhie SK, Berman BP, Coetzee GA, & Noushmehr H. (2012) FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs. Nucleic acids research, 40(18). PMID: 22684628
The mitochondria, often referred to as the “power-house” of the cell, provide a platform for energy production through glucose metabolism. As a bi-product of this, they also are the major producer of reactive oxidative species. Mitochondria also play other important physiological roles, such as calcium homeostasis and aid in the regulation of cell death through ...
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Chestnut BA, Chang Q, Price A, Lesuisse C, Wong M, & Martin LJ. (2011) Epigenetic regulation of motor neuron cell death through DNA methylation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(46), 16619-36. PMID: 22090490
Manev H, Dzitoyeva S, & Chen H. (2012) Mitochondrial DNA: A Blind Spot in Neuroepigenetics. Biomolecular concepts, 3(2), 107-115. PMID: 22639700
Shock LS, Thakkar PV, Peterson EJ, Moran RG, & Taylor SM. (2011) DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 108(9), 3630-5. PMID: 21321201
Wong M, Gertz B, Chestnut BA, & Martin LJ. (2013) Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS. Frontiers in cellular neuroscience, 279. PMID: 24399935
Tamoxifen and aromatase inhibitors (AIs) are both treatment options for patients with breast tumors that express estrogen receptor (ER) α and that require estrogen for growth. Tamoxifen competes with estrogen in binding to the ER, but does not activate the receptor. In comparison, AIs lower estrogen levels in the body by blocking the conversion of ...The post The Battle for HOXC10 in the War Against Breast Cancer appeared first on EpiBeat.... Read more »
Pathiraja TN, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ.... (2014) Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer. Science translational medicine, 6(229). PMID: 24670685
The discovery of induced pluripotent stem cells (iPSCs) and the creation of clinically relevant cell types derived from them, have been great leaps toward the implementation of stem cell based therapies and disease models. But in recent years, concerns have risen about iPSCs “remembering” their original cell types and favoring differentiation towards their origins. This ...The post iPSC Epigenetic Memory: One more Roadblock for Regenerative Medicine? appeared first on EpiBeat.... Read more »
Roessler R, Smallwood SA, Veenvliet JV, Pechlivanoglou P, Peng SP, Chakrabarty K, Groot-Koerkamp MJ, Pasterkamp RJ, Wesseling E, Kelsey G.... (2014) Detailed Analysis of the Genetic and Epigenetic Signatures of iPSC-Derived Mesodiencephalic Dopaminergic Neurons. Stem cell reports, 2(4), 520-33. PMID: 24749075
There is now mounting evidence that diet and other environmental factors can have widespread and long-lasting influences on a developing fetus. Historically, folic acid supplementation is recommended to pregnant mothers as a means to prevent developmental disorders and birth defects. However, there is still no clear understanding how such supplementation may influence a developing child’s ...The post Maternal Diet Affects DNA Methylation Patterns in Offspring appeared first on EpiBeat.... Read more »
Barua S, Kuizon S, Chadman KK, Flory MJ, Brown WT, & Junaid MA. (2014) Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid. Epigenetics , 7(1), 3. PMID: 24484737
The prevalence of Autism Spectrum Disorder (ASD) has increased by roughly 30% since 2012. The CDC recently reported that one in 68 children in the United States is affected by ASD, compared to one in 88 just two years ago. This enhanced occurrence could be attributed to advancements in the detection and diagnosis, increased awareness, ...The post April is Autism Awareness Month: Increased levels of 5-hmC may influence gene regulation in Autism Spectrum Disorder appeared first on EpiBeat.... Read more »
Zhubi A, Chen Y, Dong E, Cook EH, Guidotti A, & Grayson DR. (2014) Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Translational psychiatry. PMID: 24448211
Breast cancer is one of the most common cancers worldwide in females. Researchers from the University of California, Los Angeles (UCLA) found that PIAS1 is linked to breast tumorigenesis. PIAS1 is a transcriptional repressor that has SUMO (small ubiquitin-like modifier) E3 ligase activity. Recently, it had been explored that PIAS1 facilitates a novel epigenetic mechanism ...The post NEW LINK FOUND BETWEEN BREAST CANCER AND EPIGENETICS appeared first on EpiBeat.... Read more »
Liu B, Tahk S, Yee KM, Yang R, Yang Y, Mackie R, Hsu C, Chernishof V, O'Brien N, Jin Y.... (2014) PIAS1 Regulates Breast Tumorigenesis through Selective Epigenetic Gene Silencing. PloS one, 9(2). PMID: 24586797
Cigarette smoking leads to some of the most preventable causes of death and illness in the world. The Centers for Disease Control (CDC) in the United States has reported that there are approximately 440,000 deaths due to smoking each year, and an additional 49,000 deaths due to secondhand smoke. Roughly 600 chemicals are found in ...The post Cigarette Smoking and Epigenetics: DNA Methylation Differences Between Ethnic Groups appeared first on EpiBeat.... Read more »
Elliott HR, Tillin T, McArdle WL, Ho K, Duggirala A, Frayling TM, Davey Smith G, Hughes AD, Chaturvedi N, & Relton CL. (2014) Differences in smoking associated DNA methylation patterns in South Asians and Europeans. Clinical epigenetics, 6(1), 4. PMID: 24485148
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