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Born in West Virginia in 1980, The Neurocritic embarked upon a roadtrip across America at the age of thirteen with his mother. She abandoned him when they reached San Francisco and The Neurocritic descended into a spiral of drug abuse and prostitution. At fifteen, The Neurocritic's psychiatrist encouraged him to start writing as a form of therapy.
Obsessive compulsive disorder (OCD) is a mental illness characterized by unwanted and intrusive thoughts, feelings, or ideas (obsessions), and ritualized behaviors (compulsions) the individual feels driven to perform in order to alleviate the disturbing nature of the obsessions. It is a major anxiety disorder classified in Axis I of the DSM-IV, which can be disabling to those who suffer with it.The specific symptoms of OCD can include fear of contamination (from germs and physical contact with........ Read more »
Koçak, O., Özpolat, A., Atbaşoğlu, C., & Çiçek, M. (2011) Cognitive control of a simple mental image in patients with obsessive–compulsive disorder. Brain and Cognition. DOI: 10.1016/j.bandc.2011.03.020
A study on electrophysiological recordings from single neurons in the dorsolateral prefrontal cortex of two monkeys trained to perform a visual target discrimination task (Lennert & Martinez-Trujillo, 2011) has supposedly given new hope to patients with a diverse array of neurological and psychiatric conditions, according to a press release:Filters That Reduce ‘brain Clutter’ IdentifiedScienceDaily (Apr. 19, 2011) — Until now, it has been assumed that people with conditions like ADHD, ........ Read more »
Lennert, T., & Martinez-Trujillo, J. (2011) Strength of Response Suppression to Distracter Stimuli Determines Attentional-Filtering Performance in Primate Prefrontal Neurons. Neuron, 70(1), 141-152. DOI: 10.1016/j.neuron.2011.02.041
What is restless legs syndrome?Restless legs syndrome (RLS) is a neurological disorder characterized by throbbing, pulling, creeping, or other unpleasant sensations in the legs and an uncontrollable, and sometimes overwhelming, urge to move them. Symptoms occur primarily at night when a person is relaxing or at rest and can increase in severity during the night. Moving the legs relieves the discomfort. Often called paresthesias (abnormal sensations) or dysesthesias (unpleasant abnormal sensation........ Read more »
Marin, L., Felicio, A., & Prado, G. (2011) Sexual intercourse and masturbation: Potential relief factors for restless legs syndrome?. Sleep Medicine, 12(4), 422. DOI: 10.1016/j.sleep.2011.01.001
This sums up the basic conclusion of a new study on political orientation and brain structure by Ryota Kanai, Tom Feilden, Colin Firth and Geraint Rees in the journal Current Biology. Yes, that Colin Firth...Colin Firth's Speech during the 2011 Academy Awards. Firth won Best Actor for The King's Speech.Why are Colin Firth and Tom Feilden, both listed with BBC Radio 4 affiliations, authors on this paper? Let's go back to Tuesday, 28 December 2010 and two pieces that appeared on the BBC website.Po........ Read more »
Ryota Kanai, Tom Feilden, Colin Firth, Geraint Rees. (2011) Political Orientations Are Correlated with Brain Structure in Young Adults. Current Biology. info:/10.1016/j.cub.2011.03.017
From Rolling Stone MagazineAn excerpt from Simon-Baron Cohen's new book, Zero Degrees of Empathy: a New Theory of Human Cruelty, appeared as The science of empathy in the Guardian. Overall, the writing revealed him to be unempathetic in some respects, particularly with regard to people with borderline personality disorder1 (BPD):Unempathic acts are simply the tail end of a bell curve, found in every population on the planet. If we want to replace the term "evil" with the term "empathy", we h........ Read more »
Fertuck, E., Jekal, A., Song, I., Wyman, B., Morris, M., Wilson, S., Brodsky, B., & Stanley, B. (2009) Enhanced ‘Reading the Mind in the Eyes’ in borderline personality disorder compared to healthy controls. Psychological Medicine, 39(12), 1979. DOI: 10.1017/S003329170900600X
Harari, H., Shamay-Tsoory, S., Ravid, M., & Levkovitz, Y. (2010) Double dissociation between cognitive and affective empathy in borderline personality disorder. Psychiatry Research, 175(3), 277-279. DOI: 10.1016/j.psychres.2009.03.002
An article from January is making the rounds again. One in nextgov's exposé-like series on America's Broken Warriors, it highlighted the fact that 20% of U.S. active duty troops are on psychotropic medications. While this may not be a good thing, the article was filled with erroneous information about specific psych meds and general scare-mongering from antipsychiatry "experts" pitching their books. Let's take a look.Military's drug policy threatens troops' health, doctors sayBy Bob Brewin 01/1........ Read more »
Holmes MK, Erickson K, Luckenbaugh DA, Drevets WC, Bain EE, Cannon DM, Snow J, Sahakian BJ, Manji HK, & Zarate CA Jr. (2008) A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression. Bipolar disorders, 10(7), 806-15. PMID: 19032712
Incecik F, Akoglu E, Sangün O, Melek I, & Duman T. (2007) Effects of valproic acid on hearing in epileptic patients. International journal of pediatric otorhinolaryngology, 71(4), 611-4. PMID: 17270285
Thompson PJ, & Trimble MR. (1981) Sodium valproate and cognitive functioning in normal volunteers. British journal of clinical pharmacology, 12(6), 819-24. PMID: 6803819
Fun With Behavior Therapy from the 70s, Part 2In our next installment of food-based behavior therapies to treat phobias in adults, we have a case report of combined exposure/M&M treatment (Kroll, 1975). First is a description of the client's fear of dogs:The client was a 22-yr-old female graduate student with a strong fear and avoidance of dogs. She had been told by her parents that a large brown dog had knocked her over when she was a child, but she did not remember the incident nor did she........ Read more »
Kroll, H. (1975) Rapid treatment of dog phobia by a feeding procedure. Journal of Behavior Therapy and Experimental Psychiatry, 6(4), 325-326. DOI: 10.1016/0005-7916(75)90071-3
Fun With Behavior Therapy from the 70s, Part 1In 1973, Bryntwick and Solyom published a paper on a new method of behavior therapy for elevator phobia, which involved depriving their clients of food and water for 24 hours. The rationale for their unorthodox approach was as follows:Fear habits in the animal laboratory have been diminished by first depriving the subject of food and then rewarding him with it in the fear provoking situation (Masserman, 1943; Wolpe, 1958). To apply this technique to ........ Read more »
Rosen, G. (1974) A critical comment on the use of food deprivation in the “Brief treatment of elevator phobia”. Journal of Behavior Therapy and Experimental Psychiatry, 5(3-4), 313. DOI: 10.1016/0005-7916(74)90087-1
Semantic dementia is a neurodegenerative disorder in the general class of frontotemporal lobar degeneration. Atrophy occurs bilaterally in the anterior temporal lobes, with the left hemisphere affected to a greater extent (Lambon Ralph & Patterson, 2008). Patients gradually lose semantic memory abilities (e.g., memory for word meanings and conceptual knowledge). Alterations in personality, interests, and tastes can be observed in some patients. A unique case study documented an increasing i........ Read more »
ROMANTIC LOVE WAS INVENTED TO MANIPULATE WOMEN-Jenny Holzer, TruismsDoes romantic love manipulate women into providing free domestic labor and sexual favors for men? Some feminist views of romantic love [and the institution of marriage] portray it as controlling and oppressive (Burns, 2000):‘STOP HUMAN SACRIFICE. END MARRIAGE NOW.’ ‘IT STARTS WHEN YOU SINK IN HIS ARMS AND ENDS WITH YOUR ARMS IN HIS SINK.’ From a feminist perspective, romantic love was, and is, seen to obscure or disguis........ Read more »
Xu, X., Aron, A., Brown, L., Cao, G., Feng, T., & Weng, X. (2011) Reward and motivation systems: A brain mapping study of early-stage intense romantic love in Chinese participants. Human Brain Mapping, 32(2), 249-257. DOI: 10.1002/hbm.21017
Zeki, S., & Romaya, J. (2010) The Brain Reaction to Viewing Faces of Opposite- and Same-Sex Romantic Partners. PLoS ONE, 5(12). DOI: 10.1371/journal.pone.0015802
Fig. 2D (Acevedo et al., 2011). Image and scatter plot illustrating greater response to the Partner (vs. a highly familiar acquaintance) in the region of the posterior hippocampus is associated with higher sexual frequency.Now there's an unexpected correlation suitable for Valentine's Day. How romantic! Actually, it is romantic because the neuroimaging study by Acevedo et al. (2011) is entitled "Neural correlates of long-term intense romantic love." How do you quantify long-term intense romantic........ Read more »
Acevedo BP, Aron A, Fisher HE, & Brown LL. (2011) Neural correlates of long-term intense romantic love. Social cognitive and affective neuroscience. PMID: 21208991
In the November 2010 issue of Perspectives in Psychological Sciences, a Special Section on "Neuroimaging: Voodoo, New Phrenology, or Scientific Breakthrough?" (Diener, 2010) looks back at the infamous paper by Vul et al. (2009) and forward into the future. In one of the articles, an extended analogy is made between modern neuroimaging and the phrenology of yore (Poldrack, 2010):Imagine that fMRI had been invented in the 1860s rather than the 1990s. Instead of being based on modern cognitive p........ Read more »
Poldrack, R. (2010) Mapping Mental Function to Brain Structure: How Can Cognitive Neuroimaging Succeed?. Perspectives on Psychological Science, 5(6), 753-761. DOI: 10.1177/1745691610388777
Diagram showing principal systems of association fibers in the human brain. The superior longitudinal fasciculus (SLF) is labeled at the center top (marked by purple arrows).New Scientist covered two journal articles by Rametti and colleagues (2010, 2011), a group of Spanish researchers and clinicians affiliated with Unidad Trastorno Identidad de Género [Gender Identity Disorder Unit]. Using the diffusion tensor imaging (DTI) method, they initially wanted to identify any sex differences in the ........ Read more »
Rametti, G., Carrillo, B., Gómez-Gil, E., Junque, C., Segovia, S., Gomez, �., & Guillamon, A. (2011) White matter microstructure in female to male transsexuals before cross-sex hormonal treatment. A diffusion tensor imaging study. Journal of Psychiatric Research, 45(2), 199-204. DOI: 10.1016/j.jpsychires.2010.05.006
Rametti, G., Carrillo, B., Gómez-Gil, E., Junque, C., Zubiarre-Elorza, L., Segovia, S., Gomez, �., & Guillamon, A. (2010) The microstructure of white matter in male to female transsexuals before cross-sex hormonal treatment. A DTI study. Journal of Psychiatric Research. DOI: 10.1016/j.jpsychires.2010.11.007
Bottom image adapted from Fig. 2 of Schumann et al. (2010). Neuroanatomy of the human amygdala postmortem. Nissl-stained section of amygdala nuclei.The amygdala is a subcortical structure located within the medial temporal lobes. It consists of a number of different nuclei, or collections of neurons delineated by commonalities in morphology and connectivity. The amygdala is best known for major roles in fear conditioning (Paré et al., 2004) and responding to emotional stimuli more generally (Ph........ Read more »
Freelance medical and science writer Rob Stepney noticed the rapid growth of "x" and "z"-named products included in the British National Formulary (BNF). So for the Christmas 2010 issue of BMJ (Stepney, 2010), he investigated this phenomenon:Of 1436 products added to the BNF between 1986 and 2005, more than a fifth had names that began with z or x or contained a prominent x or z within them. In 1986, only 19 branded drugs began with one of these letters. Over the next two decades, the numbe........ Read more »
Crucifixion, by Francis Bacon (1933).Crucifixion (1933) (oil on canvas) was subsequently purchased by Sir Michael Sadler (who, other than friends or relations, was the first to buy a painting), and who also commissioned a second version, Crucifixion (1933) (chalk, gouache and pencil), and sent Bacon an x-ray photograph of his own skull, with a request that he paint a portrait from it. Bacon duly incorporated the x-ray directly into The Crucifixion (1933).A paper by an interdisciplinary team of S........ Read more »
Marinkovic, S., Stošic-Opincal, T., Štrbac, M., Tomic, I., Tomic, O., & Djordjevic, D. (2010) Neuroradiology and Art: A Review and Personal Contribution. The Tohoku Journal of Experimental Medicine, 222(4), 297-302. DOI: 10.1620/tjem.222.297
Case Report: novel treatment initiated by the patient to treat her symptoms of ocular neuromyotonia, or spontaneous spasms of the extraocular muscles.
As part of the Christmas 2010 issue of BMJ, Weston et al. (2010) reported the case of a 68 yr old woman with intermittent diplopia, or double vision. A cataract on her left eye was removed, which improved her vision.... Read more »
The Seductive Allure of Neuroscience ExplanationsThe previous post, Voodoo Correlations: Two Years Later, was a retrospective on the neuroimaging methods paper that was widely discussed in the blogosphere before it was considered "officially" published (Vul et al., 2009). The article, a controversial critique of the statistical analyses used by fMRI investigators in social neuroscience, made its initial appearance on Ed Vul's website once it was accepted by Perspectives in Psychological Sciences........ Read more »
Neurokitchen Design is the latest fad among the rich and famous, according to a poorly researched article in the Wall Street Journal:A Kitchen to Comfort Your SoulCombining psychology and neuroscience, Johnny Grey is an interior designer with a special recipeBy TARA LOADER WILKINSON'You can tell a lot about a person from their kitchen," says Johnny Grey, an award-winning interior designer specializing in "happy kitchens," a design philosophy that focuses on bringing emotional, physical and psy........ Read more »
Trout, J. (2008) Seduction without cause: uncovering explanatory neurophilia. Trends in Cognitive Sciences, 12(8), 281-282. DOI: 10.1016/j.tics.2008.05.004
Fig 1A (modified from Blauwblomme et al., 2010). Top: coronal and lateral representation of the stereotaxic implantation scheme. Bottom: reflex seizure showing ictal onset in the right insula and secondary spreading in the hippocampus.Reflex epilepsy is a rare neurological condition in which seizures are triggered by a specific type of sensory input (Xue & Ritaccio, 2006). The most common reflex seizures are induced by light, but other reported triggers have included reading, Mah-Jong, mus........ Read more »
Blauwblomme, T., Kahane, P., Minotti, L., Grouiller, F., Krainik, A., Vercueil, L., Chabardes, S., Hoffmann, D., & David, O. (2010) Multimodal imaging reveals the role of activity in eating-reflex seizures. Journal of Neurology, Neurosurgery . DOI: 10.1136/jnnp.2010.212696
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