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新之艺
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- September 13, 2009
- 01:37 PM
- 444 views
跳动的多样性
by Xinwei Han in 新之艺
长散在核重复序列(LINE,Long interspersed element)本身就是一种很令人惊奇的序列。根据wikipedia, 人类基因组中有大约900000个拷贝，占全基因组的21%。但如此众多的序列对真核生物的生存却没有重要的作用，事实上LINE是一种反转录转座子，它们在基因组中跳来跳去，更像是寄生在基因组中的病毒。 可以想见，LINE如果插入到coding sequences或regulatory sequences中，会引起失活突变. 大多数情........ Read more »
Coufal, N., Garcia-Perez, J., Peng, G., Yeo, G., Mu, Y., Lovci, M., Morell, M., O’Shea, K., Moran, J., & Gage, F. (2009) L1 retrotransposition in human neural progenitor cells. Nature, 460(7259), 1127-1131. DOI: 10.1038/nature08248
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