9 posts · 1,048 views
Researching the function of neurogenesis in the adult brain. Trying my best to communicate it...
Functional Neurogenesis
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- August 31, 2010
- 12:22 AM
- 33 views
Someone finally dissects the role new neurons play in fear conditioning
by Jason Snyder in Functional Neurogenesis
Based on a true story – how progress is made in the field of adult neurogenesis*
A group of scientists reduce neurogenesis and report a memory deficit.
A second group repeats the experiment, with only a few minor differences in protocol, and fails to find a memory deficit.
A third group, using the same species as the first [...]... Read more »
Drew MR, Denny CA, & Hen R. (2010) Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning. Behavioral neuroscience, 124(4), 446-54. PMID: 20695644
- August 23, 2010
- 10:45 AM
- 49 views
Do new neurons go through a critical period and then retire, never to be used again?
by Jason Snyder in Functional Neurogenesis
And here we have the latest, craziest hypothesis of granule cell function. Crazy not because the authors have lost their minds but because the story of the dentate gyrus, where adult neurogenesis occurs, is becoming more peculiar every day. The underlying premise of this paper by Alme et al. (which we will examine later) is [...]... Read more »
Alme, C., Buzzetti, R., Marrone, D., Leutgeb, J., Chawla, M., Schaner, M., Bohanick, J., Khoboko, T., Leutgeb, S., Moser, E.... (2010) Hippocampal granule cells opt for early retirement. Hippocampus. DOI: 10.1002/hipo.20810
- May 12, 2010
- 03:30 AM
- 117 views
What IS the dentate gyrus doing to CA3?
by Jason Snyder in Functional Neurogenesis
A fundamental property of the hippocampus is its ability to rapidly encode memories while simultaneously keeping them distinct. Recording from hippocampal neurons one can clearly see that different populations of neurons are active as a rat explores two environments. This is thought to be one mechanism by which information is kept distinct in the brain.
For [...]... Read more »
Leutgeb JK, Leutgeb S, Moser MB, & Moser EI. (2007) Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science, 315(5814), 961-6. PMID: 17303747
- May 3, 2010
- 03:39 AM
- 126 views
Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons
by Jason Snyder in Functional Neurogenesis
Dendrites are the extensions of neurons that receive incoming information. Neurons have primary dendrites that further split off into secondary and tertiary dendritic branches. On each of these branches are thousands of synaptic connections with axons of neurons carrying incoming information. The result is a dendritic tree that is capable of receiving and integrating a wide array [...]... Read more »
Tronel S, Fabre A, Charrier V, Oliet SH, Gage FH, & Abrous DN. (2010) Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America, 107(17), 7963-8. PMID: 20375283
- April 15, 2010
- 01:10 PM
- 173 views
Increased neurogenesis is not (necessarily) the opposite of reduced neurogenesis
by Jason Snyder in Functional Neurogenesis
Two recent papers have attracted a lot of media attention because they draw direct links between adult neurogenesis and behavioral disorders: Noonan et al. showed that rats lacking adult neurogenesis (stopped with irradiation) are more susceptible to cocaine addiction. Jin et al. showed that mice lacking adult neurogenesis (using a transgenic model) suffer greater infarct [...]... Read more »
Noonan MA, Bulin SE, Fuller DC, & Eisch AJ. (2010) Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(1), 304-15. PMID: 20053911
Jin K, Wang X, Xie L, Mao XO, & Greenberg DA. (2010) Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID: 20385829
- March 22, 2010
- 04:17 PM
- 142 views
The first example of functional neurogenesis?
by Jason Snyder in Functional Neurogenesis
I recently became re-acquainted with the neurogenesis literature while writing the last post, re-finding data in papers whose gist, but not details, I had remembered. I reached out a little bit, asking others if I had forgot any studies and indeed I had, including this study by Okano, Pfaff and Gibbs from 1993.
I’ve been [...]... Read more »
Okano HJ, Pfaff DW, & Gibbs RB. (1993) RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(7), 2930-8. PMID: 8331381
- February 4, 2010
- 04:06 PM
- 207 views
Adult neurogenesis in humans: Murine Features of Neurogenesis in the Human Hippocampus
by Jason Snyder in Functional Neurogenesis
Studies of adult neurogenesis often begin with the following sentence: “Adult neurogenesis occurs in all mammals examined, including humans.” More detail-oriented papers might say, “Adult neurogenesis occurs in all mammals examined, including humans…but not bats.” Here, the similarities between bats and humans become more evident than one might expect: it could be an equally long [...]... Read more »
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R., Horvat, V., Volk, B., & Kempermann, G. (2010) Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008809
- January 25, 2010
- 01:22 PM
- 90 views
Decade in review #1: the neurogenesis-depression hypothesis
by Jason Snyder in Functional Neurogenesis
A major theme in the field of adult neurogenesis is the neurogenesis-depression hypothesis, the idea that newborn neurons are protective against depression. ... Read more »
Malberg JE, Eisch AJ, Nestler EJ, & Duman RS. (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(24), 9104-10. PMID: 11124987
Santarelli, L. (2003) Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants. Science, 301(5634), 805-809. DOI: 10.1126/science.1083328
- December 22, 2009
- 11:42 AM
- 111 views
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory
by Jason Snyder in Functional Neurogenesis
A review of the Cell paper by Kitamura, Inokuchi and colleagues on the role of adult-born neurons in systems consolidation of memory.... Read more »
Kitamura T, Saitoh Y, Takashima N, Murayama A, Niibori Y, Ageta H, Sekiguchi M, Sugiyama H, & Inokuchi K. (2009) Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell, 139(4), 814-27. PMID: 19914173
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