11 posts · 12,120 views
I am a computational biologist working as a Research Associate at Imperial College London. I did my Ph.D. at the Universty of Tokyo with Hirohisa Kishino, and I have an M.Sc. in Biotechnology and a B.Sc. in Molecular Sciences completed at the University of Sao Paulo, Brasil. I also worked in Spain for five years as a postdoc in the Phylogenomics Lab of David Posada.
When we have sequence alignments regarding several genes from a group of taxa, we usually want to extract the phylogenetic information common to all of them. However, in many cases such phylogenomic analyses depend on selecting one sequence from each species per gene family (=alignment), or excluding paralogs, or partitioning these paralogous sequences into loci, or utilizing only gene families without apparent paralogs. If we want to analyse all our data at once, without excluding sequences or ........ Read more »
de Oliveira Martins Leonardo, Mallo Diego, & Posada David. (2014) A Bayesian Supertree Model for Genome-Wide Species Tree Reconstruction. Systematic Biology. DOI: http://dx.doi.org/10.1093/sysbio/syu082
Just to complement my answer to a blog post, where I maintain that the Nearest-Neighbor Interchange (NNI) distance is not equivalent to the Robinson-Foulds (RF) distance, a simple example:Where we can see that trees T1 and T2 differ only in the location of nodes A and B -- on these trees, we can naturally think of the nodes A, B, 1,..., 6 as representing leaves, but they might also be large subtrees.The RF distance is the number of edges (=branches) that are unique to each tree (that's why it's ........ Read more »
Our commentary on Douglas Theobald's test from Universal Common Ancestry (UCA) just went online. The original idea was to make a user-friendly review of his analysis described in "A formal test of the theory of universal common ancestry", but after a long e-mail exchange between Douglas and us -- actually between him and David, I didn't say much -- we decided to expand the article to include some remaining points of skepticism and spell out the basic problem with his approach.His work His test f........ Read more »
Leonardo de Oliveira Martins, David Posada. (2012) Proving universal common ancestry with similar sequences. Trends in Evolutionary Biology, 14(1). info:/10.4081/eb.2012.e5
Theobald, D. (2010) A formal test of the theory of universal common ancestry. Nature, 465(7295), 219-222. DOI: 10.1038/nature09014
After running a Bayesian phylogenetic analysis we are usually left with a large collection of trees, that came from the posterior distribution of the model given our data. Then if we want to work with a single tree - that is, to have a point estimate of this posterior distribution of trees - the most usual ways are to calculate the consensus tree or to select the most frequent tree. There are other ways, but let's fix on those by now.We might not be aware of it, but when we choose for one or ano........ Read more »
I just came back from SMBE2010, where I presented a poster about our recombination detection software and had the chance to see awesome research other people are doing. The poster can be downloaded here (1.MB in pdf format) and I’m distributing it under the Creative Commons License. Given the great feedback I got from other [...]... Read more »
de Oliveira Martins, L., Leal, É., & Kishino, H. (2008) Phylogenetic Detection of Recombination with a Bayesian Prior on the Distance between Trees. PLoS ONE, 3(7). DOI: 10.1371/journal.pone.0002651
Oliveira Martins, L., & Kishino, H. (2009) Distribution of distances between topologies and its effect on detection of phylogenetic recombination. Annals of the Institute of Statistical Mathematics, 62(1), 145-159. DOI: 10.1007/s10463-009-0259-8
Despite I’m very charitable when testing my own programs, I’m not so nice when asked to scrutinize other people’s work. That’s why I was happy to see the announcement about the ALTER web server being published at Nucleic Acids Research (open access!). I am not involved in the project, but I was in the very [...]... Read more »
Glez-Pena, D., Gomez-Blanco, D., Reboiro-Jato, M., Fdez-Riverola, F., & Posada, D. (2010) ALTER: program-oriented conversion of DNA and protein alignments. Nucleic Acids Research. DOI: 10.1093/nar/gkq321
No primeiro post, vimos que os primeiros neandertais apareceram cerca de 400 mil anos atrás, que estavam restritos à Europa e à Ásia Ocidental, e que desapareceram há cerca de 30 mil anos. Humanos modernos também se originaram na África e foram se expandindo ao redor do globo, a partir de uns 80 mil anos atrás. Continuando então a leitura sobre o neandertal, vejamos agora o artigo mais comentado (e o comentário na revista).A a........ Read more »
Dos dois artigos descrevendo o genoma do neandertal, um que me pareceu ter recebido menos atenção foi um em colaboração com o laboratório de Cold Spring Harbor. Nele os autores descrevem a técnica de captura por hibridização em microarray, que permite "filtrar" regiões do genoma de interesse. As regiões interessantes são seqüencias de DNA que codificam para proteínas, e especificamente regiõ........ Read more »
Burbano, H., Hodges, E., Green, R., Briggs, A., Krause, J., Meyer, M., Good, J., Maricic, T., Johnson, P., Xuan, Z.... (2010) Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture. Science, 328(5979), 723-725. DOI: 10.1126/science.1188046
A descoberta científica da semana, sem dúvida, foi o sequenciamento do genoma do neandertal. Para mim, talvez seja a descoberta do ano (e olha que este ano temos muitas novidades). Não apenas temos o genoma (quase) completo de um animal extinto, mas também é o animal mais próximo ao humano moderno (o Homo sapiens sapiens). O "nome completo" do homem de Neandertal é Homo neanderthalensis ou Homo sapiens neanderthalensis, e já d&aac........ Read more »
Recently a paper about the software MANTiS called my attention, and I’ve been trying to write about it for a while. This announcement at the EvolDir list seemed like the perfect opportunity. I must warn you though that I’ve never used the software and I don’t have any intimacy with the underlying databases, but the [...]... Read more »
Milinkovitch, M., Helaers, R., & Tzika, A. (2009) Historical Constraints on Vertebrate Genome Evolution. Genome Biology and Evolution, 13-18. DOI: 10.1093/gbe/evp052
Tzika, A., Helaers, R., Van de Peer, Y., & Milinkovitch, M. (2007) MANTIS: a phylogenetic framework for multi-species genome comparisons. Bioinformatics, 24(2), 151-157. DOI: 10.1093/bioinformatics/btm567
In recent years there has been an explosion of parallel algorithms for solving bioinformatics problems, namely phylogenetic reconstruction and sequence alignment. These algorithms follow the growth of new hardware solutions like Field-Programmable Gate Arrays (integrated circuits capable of performing simple instructions in parallel), Cell microprocessors (like the one inside Playstation 3), Graphics Processing Units (nvidia [...]... Read more »
Galvez, S., Diaz, D., Hernandez, P., Esteban, F., Caballero, J., & Dorado, G. (2010) Next-generation bioinformatics: using many-core processor architecture to develop a web service for sequence alignment. Bioinformatics, 26(5), 683-686. DOI: 10.1093/bioinformatics/btq017
Manavski, S., & Valle, G. (2008) CUDA compatible GPU cards as efficient hardware accelerators for Smith-Waterman sequence alignment. BMC Bioinformatics, 9(Suppl 2). DOI: 10.1186/1471-2105-9-S2-S10
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