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the Node
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- February 7, 2013
- 11:36 AM
- 50 views
Review: Electric shock
Last year, Matter launched, after a successful Kickstarter campaign, as a magazine that publishes only long, well-written articles related to “science, technology and the ideas shaping our future”. Each issue is one article, which costs $0.99 to access. (On my iPad, they ‘re categorized as books, and are each about 40 pages long, which I [...]... Read more »
Tseng AiSun, & Levin Michael. (2013) Cracking the bioelectric code: Probing endogenous ionic controls of pattern formation. Communicative , 6(1). DOI: 10.4161/cib.22595
Tseng A.-S., Beane W. S., Lemire J. M., Masi A., & Levin M. (2010) Induction of Vertebrate Regeneration by a Transient Sodium Current. Journal of Neuroscience, 30(39), 13192-13200. DOI: 10.1523/JNEUROSCI.3315-10.2010
Beane W. S., Morokuma J., Lemire J. M., & Levin M. (2013) Bioelectric signaling regulates head and organ size during planarian regeneration. Development, 140(2), 313-322. DOI: 10.1242/dev.086900
Pai V. P., Aw S., Shomrat T., Lemire J. M., & Levin M. (2012) Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis. Development, 139(2), 313-323. DOI: 10.1242/dev.073759
- August 21, 2012
- 05:52 AM
- 269 views
Virtual nanoscopy
Let’s take a very close look at the inside of a fish! A recent paper in the Journal of Cell Biology describes a technique for generating large, composite, images from electron microscopy data. Frank Faas, Raimond Ravelli, and colleagues at the Leiden University Medical Center developed a method to computationally collect and align EM images. [...]... Read more »
Faas FG, Avramut MC, M van den Berg B, Mommaas AM, Koster AJ, & Ravelli RB. (2012) Virtual nanoscopy: Generation of ultra-large high resolution electron microscopy maps. The Journal of cell biology, 198(3), 457-69. PMID: 22869601
- August 1, 2012
- 12:07 PM
- 350 views
What’s in the culture medium in IVF labs?
British researchers working with human embryos for IVF have been wondering about the effects of components of the culture medium they use. In the UK, culture media used for IVF and fertility research are regulated by the Medicines and Healthcare Regulatory Agency (MHRA) and at European level. Regulation ensures that all researchers and clinicians in [...]... Read more »
Harper J, Magli MC, Lundin K, Barratt CL, & Brison D. (2012) When and how should new technology be introduced into the IVF laboratory?. Human reproduction (Oxford, England), 27(2), 303-13. PMID: 22166806
Dumoulin JC, Land JA, Van Montfoort AP, Nelissen EC, Coonen E, Derhaag JG, Schreurs IL, Dunselman GA, Kester AD, Geraedts JP.... (2010) Effect of in vitro culture of human embryos on birthweight of newborns. Human reproduction (Oxford, England), 25(3), 605-12. PMID: 20085915
- April 27, 2012
- 04:09 AM
- 363 views
Interview with Beddington Medal winner Boyan Bonev
Each year, the British Society for Developmental Biology awards the Beddington Medal for the best PhD thesis in developmental biology. At the 2012 BSDB meeting, this award went to Boyan Bonev, who completed his PhD in Nancy Papalopulu’s lab at the University of Manchester. At the conference, Boyan gave a talk about his PhD work, [...]... Read more »
Bonev, B., Pisco, A., & Papalopulu, N. (2011) MicroRNA-9 Reveals Regional Diversity of Neural Progenitors along the Anterior-Posterior Axis. Developmental Cell, 20(1), 19-32. DOI: 10.1016/j.devcel.2010.11.018
Dajas-Bailador, F., Bonev, B., Garcez, P., Stanley, P., Guillemot, F., & Papalopulu, N. (2012) microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons. Nature Neuroscience, 15(5), 697-699. DOI: 10.1038/nn.3082
- December 20, 2011
- 07:07 AM
- 880 views
Eye-ing the body electric
How do you make an eye? One early trigger for eye formation in Xenopus, as a new Development paper from Michael Levin’s lab shows, is a small change in bioelectric signals. In fact, that trigger alone is enough to induce eye development in other parts of the body. In an experiment that measured regions of [...]... Read more »
Pai, V., Aw, S., Shomrat, T., Lemire, J., & Levin, M. (2011) Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis. Development. DOI: 10.1242/dev.073759
- October 3, 2011
- 07:30 AM
- 1,169 views
Today’s Nobel Prize is not immune to developmental biology
This year’s Nobel Prize in Physiology or Medicine has just been announced, and the winners are Bruce Beutler (The Scripps Research Institute), Jules Hoffmann (University of Strasbourg) and Ralph Steinman (Rockefeller University), for their research on the immune system. Steinman discovered dendritic cells, while Beutler and Hoffmann studied the genetics behind immunity. At first glance, [...]... Read more »
LEMAITRE, B., NICOLAS, E., MICHAUT, L., REICHHART, J., & HOFFMANN, J. (1996) The Dorsoventral Regulatory Gene Cassette Controls the Potent Antifungal Response in Drosophila Adults. Cell, 86(6), 973-983. DOI: 10.1016/S0092-8674(00)80172-5
Siggs, O., Arnold, C., Huber, C., Pirie, E., Xia, Y., Lin, P., Nemazee, D., & Beutler, B. (2011) The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nature Immunology, 12(5), 434-440. DOI: 10.1038/ni.2012
- June 9, 2011
- 07:37 AM
- 1,014 views
Embryonic development informs adult heart repair
After a heart attack, heart muscle is irreparably damaged, but a paper in Nature now reports that adult mouse hearts have a source of progenitor cells that can form new muscle cells after heart injury. A few years ago, studies showed that embryonic epicardial progenitor cells contribute to the cardiomyocyte lineage in developing mouse hearts. [...]... Read more »
Nicola Smart, Sveva Bollini, Karina N. Dubé, Joaquim M. Vieira, Bin Zhou, Sean Davidson, Derek Yellon, Johannes Riegler, Anthony N. Price, Mark F. Lythgoe.... (2011) De novo cardiomyocytes from within the activated adult heart after injury. Nature. info:/10.1038/nature10188
Nicola Smart, Catherine A. Risebro, Athalie A. D. Melville, Kelvin Moses, Robert J. Schwartz, Kenneth R. Chien, & Paul R. Riley. (2007) Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 177-182. info:/10.1038/nature05383
Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X.... (2008) A myocardial lineage derives from Tbx18 epicardial cells. Nature, 454(7200), 104-8. PMID: 18480752
Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR.... (2008) Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature, 454(7200), 109-13. PMID: 18568026
- May 11, 2011
- 06:00 AM
- 1,044 views
Interview with Beddington Medal winner Carlos Carmona-Fontaine
Each year, the British Society for Developmental Biology awards the Beddington Medal for the best PhD thesis in developmental biology. At the 2011 BSDB meeting, this award went to Carlos Carmona-Fontaine, who completed his PhD in Roberto Mayor’s lab at UCL. Now a postdoc at Sloan-Kettering Institute in New York, Carlos returned to the UK [...]... Read more »
Carmona-Fontaine, C., Matthews, H., Kuriyama, S., Moreno, M., Dunn, G., Parsons, M., Stern, C., & Mayor, R. (2008) Contact inhibition of locomotion in vivo controls neural crest directional migration. Nature, 456(7224), 957-961. DOI: 10.1038/nature07441
Bazazi, S., Buhl, J., Hale, J., Anstey, M., Sword, G., Simpson, S., & Couzin, I. (2008) Collective Motion and Cannibalism in Locust Migratory Bands. Current Biology, 18(10), 735-739. DOI: 10.1016/j.cub.2008.04.035
- April 7, 2011
- 06:40 AM
- 1,422 views
A new view on eye development
How do you make an eye? In the developing embryo, this process begins with the formation of the optic vesicle from the neural tube. This optic vesicle then invaginates to form an optic cup, which in turn develops into the outer pigmented layer of the retina and the inner neurosensory layer. Normally, this all takes [...]... Read more »
Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., & Sasai, Y. (2011) Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature, 472(7341), 51-56. DOI: 10.1038/nature09941
- March 31, 2011
- 07:06 AM
- 1,501 views
Marion Silies wins GfE thesis award
Every two years, the German society for developmental biology (Gesellschaft für Entwicklungsbiologie - GfE) hands out an award for the best PhD thesis of the previous two years. At their society meeting last week, this award went to Marion Silies, for her PhD thesis on glial cell migration. I met up with Marion after her [...]... Read more »
Silies M, & Klämbt C. (2010) APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS. Nature neuroscience, 13(11), 1357-64. PMID: 20890296
- January 6, 2011
- 09:50 AM
- 967 views
modENCODE
The modENCODE project (model organism encyclopedia of DNA elements) is a collaborative effort to identify all sequence-based functional elements of Drosophila and C. elegans. The project has now produced almost a thousand data sets with information about transcription, epigenetics, replication and gene regulation across different developmental stages and multiple cell lines.
Just before the holidays, [...]... Read more »
The modENCODE Consortium, ., Roy, S., Ernst, J., Kharchenko, P., Kheradpour, P., Negre, N., Eaton, M., Landolin, J., Bristow, C., Ma, L.... (2010) Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE. Science, 330(6012), 1787-1797. DOI: 10.1126/science.1198374
- September 27, 2010
- 12:19 PM
- 1,210 views
Pleiades Promoter Project
A recent paper in PNAS describes the development of MiniPromoters: human DNA promoters of less than 4 kb, designed to drive gene expression in specific areas of the brain. The initiative is called the Pleiades Promoter Project, and so far they have confirmed brain-region specific activity in knockin mice for 27 of their MiniPromoters. The [...]... Read more »
Portales-Casamar, E., Swanson, D., Liu, L., Leeuw, C., Banks, K., Ho Sui, S., Fulton, D., Ali, J., Amirabbasi, M., Arenillas, D.... (2010) A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proceedings of the National Academy of Sciences, 107(38), 16589-16594. DOI: 10.1073/pnas.1009158107
- September 2, 2010
- 12:01 PM
- 1,660 views
Evolution of cerebral cortex traced back to Precambrian era
In a paper published today in Cell, Detlev Arendt, Raju Tomer and colleagues reveal evidence that the cerebral cortex evolved much earlier than previously believed. Using a new technique to detect and image simultaneously expressed genes in a compact brain area, they discovered that the gene expression patterns in the olfactory processing region (mushroom bodies) [...]... Read more »
Raju Tomer, Alexandru S. Denes, Kristin Tessmar-Raible, & Detlev Arendt. (2010) Profiling by Image Registration Reveals Common Origin of Annelid Mushroom Bodies and Vertebrate Pallium. Cell, 142(5), 800-809. info:/10.1016/j.cell.2010.07.043
- September 1, 2010
- 10:17 AM
- 1,445 views
Phenologs and unlikely models
“You’re probably wondering why I’m here”, were the first words of Edward Marcotte’s talk at the SDB meeting last month. After all, he was about to speak about systems biology in a session on organogenesis. What followed was not only a new way to identify genes involved in developmental processes, but also a perfect example [...]... Read more »
Kriston L. McGary, Tae Joo Park, John O. Woods, Hye Ji Cha, John B. Wallingford, & Edward M. Marcotte. (2010) Systematic discovery of nonobvious human disease models through orthologous phenotypes. PNAS. DOI: 10.1073/pnas.0910200107
- August 2, 2010
- 04:17 AM
- 1,933 views
The Intestinal Crypt
It’s not often that the introductory part of a research talk is beautiful as well as informative, but Hans Clevers achieves both by using this video about the intestinal crypt in his presentations. (Click either screenshot to see the video)
The video shows how stem cells at the base of the intestinal crypt produce the epithelial [...]... Read more »
Barker, N., van Es, J., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P.... (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 449(7165), 1003-1007. DOI: 10.1038/nature06196
Barker, N., Ridgway, R., van Es, J., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A., Sansom, O., & Clevers, H. (2008) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature, 457(7229), 608-611. DOI: 10.1038/nature07602
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