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That's Basic Science
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Microbe Diaries at the CII
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by Nsikan Akpan in That's Basic Science
Follow-up to my story in Scientific American: ""Fiscal cliff" threatens to impede biomedical discoveries:... Read more »
Wadman M. (2012) NIH tackles major workforce issues. Nature, 492(7428), 167. PMID: 23235855
by Nsikan Akpan in That's Basic Science
New techniques for growing cold viruses could be the key to finding a vaccine.... Read more »
Bochkov YA, Palmenberg AC, Lee WM, Rathe JA, Amineva SP, Sun X, Pasic TR, Jarjour NN, Liggett SB, & Gern JE. (2011) Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nature medicine, 17(5), 627-32. PMID: 21483405
Hao W, Bernard K, Patel N, Ulbrandt N, Feng H, Svabek C, Wilson S, Stracener C, Wang K, Suzich J.... (2012) Infection and propagation of human rhinovirus C in human airway epithelial cells. Journal of virology, 86(24), 13524-32. PMID: 23035218
by Nsikan Akpan in That's Basic Science
Japanese scientists show how the neurotransmitter serotonin factors into the ability to wait, while researchers from the UK tell us why blocking serotonin in the liver improves wound healing after an injury.... Read more »
Miyazaki KW, Miyazaki K, & Doya K. (2012) Activation of dorsal raphe serotonin neurons is necessary for waiting for delayed rewards. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(31), 10451-7. PMID: 22855794
by Nsikan Akpan in That's Basic Science
A special llama antibody used as a powerful inhibitor for HIV. ... Read more »
Forsman A, Beirnaert E, Aasa-Chapman MM, Hoorelbeke B, Hijazi K, Koh W, Tack V, Szynol A, Kelly C, McKnight A.... (2008) Llama antibody fragments with cross-subtype human immunodeficiency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120. Journal of virology, 82(24), 12069-81. PMID: 18842738
McCoy LE, Quigley AF, Strokappe NM, Bulmer-Thomas B, Seaman MS, Mortier D, Rutten L, Chander N, Edwards CJ, Ketteler R.... (2012) Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization. The Journal of experimental medicine, 209(6), 1091-103. PMID: 22641382
Strokappe N, Szynol A, Aasa-Chapman M, Gorlani A, Forsman Quigley A, Hulsik DL, Chen L, Weiss R, de Haard H, & Verrips T. (2012) Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C. PloS one, 7(3). PMID: 22438910
by Nsikan Akpan in That's Basic Science
MIT/Harvard study finds that liver toxins spread from cell-to-cell via gap junctions. ... Read more »
Patel, S., Milwid, J., King, K., Bohr, S., Iracheta-Velle, A., Li, M., Vitalo, A., Parekkadan, B., Jindal, R., & Yarmush, M. (2012) Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure. Nature Biotechnology, 30(2), 179-183. DOI: 10.1038/nbt.2089
by Center for Infection & Immunity in Microbe Diaries at the CII
Update on Neurotropic Infections.
Formatted link:
http://cii.columbia.edu/blog.htm?cid=6RxtQJ
Twitter @cii722... Read more »
Major EO, & Nath A. (2012) Neurological infections: risks of globalisation and new drugs. Lancet neurology, 11(1), 14-5. PMID: 22172615
by Nsikan Akpan in That's Basic Science
Via my new Nature Network blog, a breathalyzer for Parkinson's disease based on carbon nanotube technology.... Read more »
Tisch, U., Aluf, Y., Ionescu, R., Nakhleh, M., Bassal, R., Axelrod, N., Robertman, D., Tessler, Y., Finberg, J., & Haick, H. (2011) Detection of Asymptomatic Nigrostriatal Dopaminergic Lesion in Rats by Exhaled Air Analysis Using Carbon Nanotube Sensors. ACS Chemical Neuroscience, 2147483647. DOI: 10.1021/cn200093r
by Nsikan Akpan in That's Basic Science
A microscopic camera for mapping atherosclerotic plaques.... Read more »
Yoo, H., Kim, J., Shishkov, M., Namati, E., Morse, T., Shubochkin, R., McCarthy, J., Ntziachristos, V., Bouma, B., Jaffer, F.... (2011) Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo. Nature Medicine, 17(12), 1680-1684. DOI: 10.1038/nm.2555
by Nsikan Akpan in That's Basic Science
Emergence of a new prion species in Switzerland implicated in mad cow disease.
(Apologies to those who tried to read this post from 4:30p - 6pm on 12/19. Had some Blogger issues.)... Read more »
Seuberlich T, Gsponer M, Drögemüller C, Polak MP, McCutcheon S, Heim D, et al. (2011) Novel prion protein in BSE-affected cattle, Switzerland. Emerging Infectious Diseases. info:/10.3201/eid1801.111225
by Nsikan Akpan in That's Basic Science
Highlights from the forthcoming tech fest SIGGRAPH Asia 2011
1) An Iphone app that writes your autobiography from internet posts
2) A Cartography graphics tool for cardiologists
3) A Renaissance collage generator.
Plus a video of some great rendering software innovations.... Read more »
Zhu, B., Iwata, M., Haraguchi, R., Ashihara, T., Umetani, N., Igarashi, T., & Nakazawa, K. (2011) Sketch-based Dynamic Illustration of Fluid Systems. ACM Transactions on Graphics, 30(6), 1. DOI: 10.1145/2070781.2024168
Huang, H., Zhang, L., & Zhang, H. (2011) Arcimboldo-like collage using internet images. ACM Transactions on Graphics, 30(6), 1. DOI: 10.1145/2070781.2024189
by Nsikan Akpan in That's Basic Science
The journey to a chlamydia vaccine has been rough, but might now be over ... Read more »
Kari, L., Whitmire, W., Olivares-Zavaleta, N., Goheen, M., Taylor, L., Carlson, J., Sturdevant, G., Lu, C., Bakios, L., Randall, L.... (2011) A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates. Journal of Experimental Medicine, 208(11), 2217-2223. DOI: 10.1084/jem.20111266
Rockey, D. (2011) Unraveling the basic biology and clinical significance of the chlamydial plasmid. Journal of Experimental Medicine, 208(11), 2159-2162. DOI: 10.1084/jem.20112088
O'Connell CM, Ingalls RR, Andrews CW Jr, Scurlock AM, & Darville T. (2007) Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease. Journal of immunology (Baltimore, Md. : 1950), 179(6), 4027-34. PMID: 17785841
O'Connell CM, AbdelRahman YM, Green E, Darville HK, Saira K, Smith B, Darville T, Scurlock AM, Meyer CR, & Belland RJ. (2011) Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum. Infection and immunity, 79(3), 1044-56. PMID: 21199910
by Nsikan Akpan in That's Basic Science
Mouse lemurs develop a disease that is strikingly similar to Alzheimer’s disease.
Advantages over current AD models:
- Short lifespan (6 – 8 yrs)
- Mimics sporadic AD
... Read more »
Languille, S., Blanc, S., Blin, O., Canale, C., Dal-Pan, A., Devau, G., Dhenain, M., Dorieux, O., Epelbaum, J., Gomez, D.... (2011) The grey mouse lemur: A non-human primate model for ageing studies. Ageing Research Reviews. DOI: 10.1016/j.arr.2011.07.001
Bons, N., Rieger, F., Prudhomme, D., Fisher, A., & Krause, K. (2006) Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease?. Genes, Brain and Behavior, 5(2), 120-130. DOI: 10.1111/j.1601-183X.2005.00149.x
by Nsikan Akpan in That's Basic Science
SfN11 video of lecture with start cues. ... Read more »
Stark CE, Okado Y, & Loftus EF. (2010) Imaging the reconstruction of true and false memories using sensory reactivation and the misinformation paradigms. Learning , 17(10), 485-8. PMID: 20861170
Gao, Y., Raine, A., Venables, P., Dawson, M., & Mednick, S. (2009) Association of Poor Childhood Fear Conditioning and Adult Crime. American Journal of Psychiatry, 167(1), 56-60. DOI: 10.1176/appi.ajp.2009.09040499
by Nsikan Akpan in That's Basic Science
Novel findings from rodent models of juvenile abuse and infant cocaine addiction... Read more »
Sadri-Vakili G, Kumaresan V, Schmidt HD, Famous KR, Chawla P, Vassoler FM, Overland RP, Xia E, Bass CE, Terwilliger EF.... (2010) Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(35), 11735-44. PMID: 20810894
by Nsikan Akpan in That's Basic Science
The influence of neuroscience on legal proceedings - a symposium at the Society of Neuroscience conference. ... Read more »
Stark CE, Okado Y, & Loftus EF. (2010) Imaging the reconstruction of true and false memories using sensory reactivation and the misinformation paradigms. Learning , 17(10), 485-8. PMID: 20861170
Gao, Y., Raine, A., Venables, P., Dawson, M., & Mednick, S. (2009) Association of Poor Childhood Fear Conditioning and Adult Crime. American Journal of Psychiatry, 167(1), 56-60. DOI: 10.1176/appi.ajp.2009.09040499
by Nsikan Akpan in That's Basic Science
Scientists discover a new facet of Ebola viral entry and a compound to stop it. ... Read more »
Carette, J., Raaben, M., Wong, A., Herbert, A., Obernosterer, G., Mulherkar, N., Kuehne, A., Kranzusch, P., Griffin, A., Ruthel, G.... (2011) Ebola virus entry requires the cholesterol transporter Niemann–Pick C1. Nature, 477(7364), 340-343. DOI: 10.1038/nature10348
Côté, M., Misasi, J., Ren, T., Bruchez, A., Lee, K., Filone, C., Hensley, L., Li, Q., Ory, D., Chandran, K.... (2011) Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection. Nature, 477(7364), 344-348. DOI: 10.1038/nature10380
by Nsikan Akpan in That's Basic Science
A neuroimaging study tries to define when pain perception crops up in infants.... Read more »
Fabrizi, L., Slater, R., Worley, A., Meek, J., Boyd, S., Olhede, S., & Fitzgerald, M. (2011) A Shift in Sensory Processing that Enables the Developing Human Brain to Discriminate Touch from Pain. Current Biology, 21(18), 1552-1558. DOI: 10.1016/j.cub.2011.08.010
Lee, S. (2005) Fetal Pain: A Systematic Multidisciplinary Review of the Evidence. JAMA: The Journal of the American Medical Association, 294(8), 947-954. DOI: 10.1001/jama.294.8.947
by Nsikan Akpan in That's Basic Science
The scientific mind behind "Contagion"... Read more »
Lipkin, W. (2010) Microbe Hunting. Microbiology and Molecular Biology Reviews, 74(3), 363-377. DOI: 10.1128/MMBR.00007-10
by Nsikan Akpan in That's Basic Science
A new method for suturing blood vessels... Read more »
Chang, E., Galvez, M., Glotzbach, J., Hamou, C., El-ftesi, S., Rappleye, C., Sommer, K., Rajadas, J., Abilez, O., Fuller, G.... (2011) Vascular anastomosis using controlled phase transitions in poloxamer gels. Nature Medicine. DOI: 10.1038/nm.2424
by Nsikan Akpan in That's Basic Science
Live imaging of synapse firing.... Read more »
Chen, X., Leischner, U., Rochefort, N., Nelken, I., & Konnerth, A. (2011) Functional mapping of single spines in cortical neurons in vivo. Nature, 475(7357), 501-505. DOI: 10.1038/nature10193
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