Shaheen Lakhan

435 posts · 751,317 views

Brain Blogger covers topics from multidimensional biopsychosocial perspectives. It reviews the latest news and stories related to neuroscience, psychiatry, and neurology. It serves as a focal point for attracting new minds beyond the science of the mind-and-brain and into the biopsychosocial model.

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  • June 17, 2011
  • 08:00 AM

Brain Growth in Autism

by Shaheen Lakhan in Brain Blogger

Brain overgrowth has been noted among children with autism spectrum disorder (ASD). Now, a new imaging study suggests that the accelerated brain growth appears before 2 years of life, offering new avenues for early identification and intervention of ASD. Investigators conducted a longitudinal magnetic resonance imaging (MRI) study of 59 children with ASD and 38 [...]... Read more »

Courchesne E, Carper R, & Akshoomoff N. (2003) Evidence of brain overgrowth in the first year of life in autism. JAMA : the journal of the American Medical Association, 290(3), 337-44. PMID: 12865374  

Courchesne E, Redcay E, & Kennedy DP. (2004) The autistic brain: birth through adulthood. Current opinion in neurology, 17(4), 489-96. PMID: 15247547  

Hazlett HC, Poe MD, Gerig G, Styner M, Chappell C, Smith RG, Vachet C, & Piven J. (2011) Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years. Archives of general psychiatry, 68(5), 467-76. PMID: 21536976  

  • June 14, 2011
  • 08:00 AM

Genetic Link to Depression Identified

by Shaheen Lakhan in Brain Blogger

Many studies have shown a heritable component to depressive disorders, but a specific cause has not been identified. Recently, scientists in two separate studies located a specific chromosomal region that is associated with depression. Both studies were recently published in the American Journal of Psychiatry. One study was led by a team at Washington University [...]... Read more »

Breen G, Webb BT, Butler AW, van den Oord EJ, Tozzi F, Craddock N, Gill M, Korszun A, Maier W, Middleton L.... (2011) A Genome-Wide Significant Linkage for Severe Depression on Chromosome 3: The Depression Network Study. The American journal of psychiatry. PMID: 21572164  

Lewis CM, Ng MY, Butler AW, Cohen-Woods S, Uher R, Pirlo K, Weale ME, Schosser A, Paredes UM, Rivera M.... (2010) Genome-wide association study of major recurrent depression in the U.K. population. The American journal of psychiatry, 167(8), 949-57. PMID: 20516156  

Pergadia ML, Glowinski AL, Wray NR, Agrawal A, Saccone SF, Loukola A, Broms U, Korhonen T, Penninx BW, Grant JD.... (2011) A 3p26-3p25 Genetic Linkage Finding for DSM-IV Major Depression in Heavy Smoking Families. The American journal of psychiatry. PMID: 21572167  

Shi J, Potash JB, Knowles JA, Weissman MM, Coryell W, Scheftner WA, Lawson WB, DePaulo JR Jr, Gejman PV, Sanders AR.... (2011) Genome-wide association study of recurrent early-onset major depressive disorder. Molecular psychiatry, 16(2), 193-201. PMID: 20125088  

Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR, Ripke S, Macintyre DJ, McGhee KA, Maclean AW.... (2010) Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Molecular psychiatry. PMID: 21042317  

  • June 11, 2011
  • 08:00 AM

Ambien, Sonata, and Lunesta – The Morning After

by Shaheen Lakhan in Brain Blogger

The latest generation of sleep hypnotics — Ambien (zolpidem), Sonata (zaleplon), and Lunesta (zopiclone) — have introduced new terms into the American lexicon. We now speak of people “sleep-driving” under the influence of these medications, for instance. The official guide that comes with Lunesta, to take one example, warns of the side effects this way: [...]... Read more »

  • June 8, 2011
  • 08:00 AM

Health Care Market Equilibrium in a Changing Environment

by Shaheen Lakhan in Brain Blogger

Strategic market planning has always been a challenge in the rapidly changing health care industry. Both internal factors of unpredictability and external market threats create waves of instability in the health care market industry. For health care consumers, this often means fluctuating health care costs and unpredictable care availability. For health care providers, this means [...]... Read more »

  • June 5, 2011
  • 08:00 AM

Domestic Violence – Understanding is Getting More Nuanced

by Shaheen Lakhan in Brain Blogger

A few years ago I brain blogged about domestic violence (DV), focusing on how ideology, politics, and stereotypes were interfering with an effective social response. It got a big response, almost entirely supportive. At that time, the tide was turning because of lawsuits and a preponderance of research that were beginning to overwhelm the dominance [...]... Read more »

  • June 2, 2011
  • 08:00 AM

Hold It! Stop Making Impulsive Decisions

by Shaheen Lakhan in Brain Blogger

To pee or not to pee? A new study published in Psychological Science says you may want to make important life decisions before finding that restroom. The study, conducted by a team in the Netherlands, evaluated how having a full bladder affected the ability to make decisions that required self-control. First, volunteers in the study [...]... Read more »

Job V, Dweck CS, & Walton GM. (2010) Ego depletion--is it all in your head? implicit theories about willpower affect self-regulation. Psychological science : a journal of the American Psychological Society / APS, 21(11), 1686-93. PMID: 20876879  

Tuk MA, Trampe D, & Warlop L. (2011) Inhibitory spillover: increased urination urgency facilitates impulse control in unrelated domains. Psychological science : a journal of the American Psychological Society / APS, 22(5), 627-33. PMID: 21467548  

  • May 30, 2011
  • 08:00 AM

Electroconvulsive Therapy in Pediatric Psychiatry

by Shaheen Lakhan in Brain Blogger

Electroconvulsive therapy (ECT) is a controversial practice of dealing with mental disorders and one that has attracted its fair share of detractors. Despite the fact that it was first used as long ago as 1938, it still carries with it a stigma that some find difficult to overlook. One might believe this method is one [...]... Read more »

Croarkin, P., McCaffrey, P., McClintock, S., Rodez, C., & Husain, M. (2009) Electroconvulsive Therapy in Child and Adolescent Psychiatry. Current Psychiatry Reviews, 5(4), 298-305. DOI: 10.2174/157340009789542141  

Greenberg RM, & Kellner CH. (2005) Electroconvulsive therapy: a selected review. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 13(4), 268-81. PMID: 15845752  

Wachtel LE, Griffin MM, Dhossche DM, & Reti IM. (2010) Brief report: Electroconvulsive therapy for malignant catatonia in an autistic adolescent. Autism : the international journal of research and practice, 14(4), 349-58. PMID: 20591959  

  • May 24, 2011
  • 08:00 AM

Adventures in the Study of Altruism

by Shaheen Lakhan in Brain Blogger

Altruism is a perplexing human trait. It is a form of behavior wherein one individual assists another without an expectation of reward and sometimes even in the face of causing oneself harm. Altruism might be considered one of those traits that distinguishes human beings from animals as it appears to be almost unique to the [...]... Read more »

Moll J, Krueger F, Zahn R, Pardini M, de Oliveira-Souza R, & Grafman J. (2006) Human fronto-mesolimbic networks guide decisions about charitable donation. Proceedings of the National Academy of Sciences of the United States of America, 103(42), 15623-8. PMID: 17030808  

Rilling JK, & Sanfey AG. (2011) The neuroscience of social decision-making. Annual review of psychology, 23-48. PMID: 20822437  

  • May 18, 2011
  • 08:00 AM

When Dieting Interferes with Dieting

by Shaheen Lakhan in Brain Blogger

The good news is that a tendency to binge on diet-destroyers is likely to be a matter of genes. The bad news is that our brain, body and external environment can fire up this tendency making some of us more likely to binge eat than others. Dietary restraint or just plain dieting involves a conscious [...]... Read more »

Racine SE, Burt SA, Iacono WG, McGue M, & Klump KL. (2011) Dietary restraint moderates genetic risk for binge eating. Journal of abnormal psychology, 120(1), 119-28. PMID: 21171725  

  • May 15, 2011
  • 08:00 AM

Pass the Salt – Risks Linked to Low Salt Diet?

by Shaheen Lakhan in Brain Blogger

In light of the fact that approximately 90% of all Americans will develop high blood pressure during their lifetime, the American Heart Association recommends a daily intake of no more than 1,500 milligrams of sodium to reduce the risk of high blood pressure, heart attacks, stroke, and kidney disease. However, results published in the Journal [...]... Read more »

Stolarz-Skrzypek K, Kuznetsova T, Thijs L, Tikhonoff V, Seidlerová J, Richart T, Jin Y, Olszanecka A, Malyutina S, Casiglia E.... (2011) Fatal and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion. JAMA : the journal of the American Medical Association, 305(17), 1777-85. PMID: 21540421  

Morrison AC, & Ness RB. (2011) Sodium intake and cardiovascular disease. Annual review of public health, 71-90. PMID: 21219163  

Centers for Disease Control and Prevention (CDC). (2010) Sodium intake among adults - United States, 2005-2006. MMWR. Morbidity and mortality weekly report, 59(24), 746-9. PMID: 20577156  

Krzesinski JM. (2009) [Sodium and arterial hypertension --one hundred years of controversies]. Bulletin et memoires de l'Academie royale de medecine de Belgique, 164(3-4), 143. PMID: 20120089  

Mattes RD, & Donnelly D. (1991) Relative contributions of dietary sodium sources. Journal of the American College of Nutrition, 10(4), 383-93. PMID: 1910064  

  • May 9, 2011
  • 08:00 AM

Maternal Relationship Reduces Violence and Improves Intelligence

by Shaheen Lakhan in Brain Blogger

There is no substitute for a good mother, and a mother’s influence is one of the most powerful forces in the lives of young children. Now, research shows that a healthy, playful relationship between a child and a mother leads to adult children with higher intelligence and less involvement in violence. Beginning in the 1980s, [...]... Read more »

  • May 3, 2011
  • 08:00 AM

Alzheimer’s Disease and Insulin Resistance

by Shaheen Lakhan in Brain Blogger

For years, researchers have noted a connection between conditions of impaired insulin use and regulation, such as obesity and type 2 diabetes, and Alzheimer’s Disease (AD), but the mechanism of association has not been well-defined. Now, researchers report that proteins that influence the development and progression of AD are suppressed by insulin, encouraging new treatment [...]... Read more »

Naderali EK, Ratcliffe SH, & Dale MC. (2009) Obesity and Alzheimer's disease: a link between body weight and cognitive function in old age. American journal of Alzheimer's disease and other dementias, 24(6), 445-9. PMID: 19801534  

Rönnemaa E, Zethelius B, Sundelöf J, Sundström J, Degerman-Gunnarsson M, Berne C, Lannfelt L, & Kilander L. (2008) Impaired insulin secretion increases the risk of Alzheimer disease. Neurology, 71(14), 1065-71. PMID: 18401020  

  • April 30, 2011
  • 08:33 AM

Reading between the Blogs

by Shaheen Lakhan in Brain Blogger

Blogger Lorelle VanFossen got it right when she wrote, “Your blog is your unedited version of yourself.” Personal blogs not only reveal bloggers’ opinions on assorted motley topics such as fashion, politics, TV shows, food, pop culture, subculture, whatnots, but also expose the bloggers’ psyche. Psychologists have long suspected links between language and personality, but [...]... Read more »

  • April 27, 2011
  • 08:00 AM

Self-Injury and the Internet

by Shaheen Lakhan in Brain Blogger

Deliberate nonsuicidal self-injury is the intentional harming of one’s own body, and may include cutting, burning, scratching, minor overdosing, banging, or hitting. New research finds that images and live-action videos depicting self-injury permeate the internet. The images are accessible to youth at risk for this dangerous behavior, and reinforce, glamorize, and provoke self-destructive behavior. The [...]... Read more »

Borzekowski DL, Schenk S, Wilson JL, & Peebles R. (2010) e-Ana and e-Mia: A content analysis of pro-eating disorder Web sites. American journal of public health, 100(8), 1526-34. PMID: 20558807  

Jett S, LaPorte DJ, & Wanchisn J. (2010) Impact of exposure to pro-eating disorder websites on eating behaviour in college women. European eating disorders review : the journal of the Eating Disorders Association, 18(5), 410-6. PMID: 20572210  

Klonsky ED, & Muehlenkamp JJ. (2007) Self-injury: a research review for the practitioner. Journal of clinical psychology, 63(11), 1045-56. PMID: 17932985  

Lewis SP, Heath NL, St Denis JM, & Noble R. (2011) The scope of nonsuicidal self-injury on YouTube. Pediatrics, 127(3). PMID: 21339269  

Nixon MK, Cloutier P, & Jansson SM. (2008) Nonsuicidal self-harm in youth: a population-based survey. CMAJ : Canadian Medical Association journal , 178(3), 306-12. PMID: 18227450  

Tuisku V, Pelkonen M, Kiviruusu O, Karlsson L, Ruuttu T, & Marttunen M. (2009) Factors associated with deliberate self-harm behaviour among depressed adolescent outpatients. Journal of adolescence, 32(5), 1125-36. PMID: 19307015  

  • April 24, 2011
  • 08:00 AM

Standardized Labels to Improve Low Health Literacy

by Shaheen Lakhan in Brain Blogger

Low health literacy contributes to medication errors, noncompliance, low quality of life, and poor health outcomes. With an aging population on a never-ending stream of prescription and over-the-counter medications, the risk of confusion and misunderstanding of drug regimens is substantial. A new study published in Archives of Internal Medicine reports that most patients cannot even [...]... Read more »

Osborn CY, Paasche-Orlow MK, Bailey SC, & Wolf MS. (2011) The mechanisms linking health literacy to behavior and health status. American journal of health behavior, 35(1), 118-28. PMID: 20950164  

Wolf MS, Curtis LM, Waite K, Bailey SC, Hedlund LA, Davis TC, Shrank WH, Parker RM, & Wood AJ. (2011) Helping patients simplify and safely use complex prescription regimens. Archives of internal medicine, 171(4), 300-5. PMID: 21357804  

Wolf MS, Davis TC, Bass PF, Curtis LM, Lindquist LA, Webb JA, Bocchini MV, Bailey SC, & Parker RM. (2010) Improving prescription drug warnings to promote patient comprehension. Archives of internal medicine, 170(1), 50-6. PMID: 20065199  

Wolf MS, Davis TC, Curtis LM, Webb JA, Bailey SC, Shrank WH, Lindquist L, Ruo B, Bocchini MV, Parker RM.... (2011) Effect of standardized, patient-centered label instructions to improve comprehension of prescription drug use. Medical care, 49(1), 96-100. PMID: 21150800  

  • April 21, 2011
  • 08:00 AM

Headache Treatment – Alternative or Illicit?

by Shaheen Lakhan in Brain Blogger

Headache disorders can be painful and debilitating conditions. Ranging from infrequent tension-type headaches to cluster headaches to migraines, headaches affect nearly every individual at one time or another. Pain – particularly of the neck and back – accompany many headaches. Traditional pharmacological treatment begins with acetaminophen (Tylenol), but this is not effective for all headache [...]... Read more »

Biondi DM. (2005) Noninvasive treatments for headache. Expert review of neurotherapeutics, 5(3), 355-62. PMID: 15938668  

Leone M, Franzini A, Cecchini AP, Mea E, Broggi G, & Bussone G. (2009) Cluster headache: pharmacological treatment and neurostimulation. Nature clinical practice. Neurology, 5(3), 153-62. PMID: 19262591  

Sewell RA. (2009) Response of cluster headache to kudzu. Headache, 49(1), 98-105. PMID: 19125878  

Sewell RA, Halpern JH, & Pope HG Jr. (2006) Response of cluster headache to psilocybin and LSD. Neurology, 66(12), 1920-2. PMID: 16801660  

  • April 18, 2011
  • 08:00 AM

Mass Murderer Psychology – The Patterns of Horror

by Shaheen Lakhan in Brain Blogger

My first reaction on learning about the Realengo school shootings in Rio de Janeiro was to feel tremendous, almost physical pain at trying to imagine what could possess a man to shoot little children at random. After writing about how I felt and the implications of the event, I came across the murderer’s letter on [...]... Read more »

Meloy JR, Hempel AG, Mohandie K, Shiva AA, & Gray BT. (2001) Offender and offense characteristics of a nonrandom sample of adolescent mass murderers. Journal of the American Academy of Child and Adolescent Psychiatry, 40(6), 719-28. PMID: 11392351  

Myers, W. (2004) Serial murder by children and adolescents. Behavioral Sciences , 22(3), 357-374. DOI: 10.1002/bsl.590  

  • April 15, 2011
  • 08:00 AM

FDA Supports Compounding of Off-Label Drug to Prevent Preterm Labor

by Shaheen Lakhan in Brain Blogger

Recently, the U.S. Food and Drug Administration (FDA) approved the new drug Makena (17-hydroxyprogesterone caproate) for the prevention of preterm labor. This is the first FDA-approved drug for this indication, but the active ingredient in the drug has been a standard of care for preventing preterm labor for nearly a decade. Until now, it has [...]... Read more »

ACOG Committee on Practice Bulletins--Obstetrics. (2003) ACOG practice bulletin. Management of preterm labor. Number 43, May 2003. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 82(1), 127-35. PMID: 12834934  

Petrini JR, Callaghan WM, Klebanoff M, Green NS, Lackritz EM, Howse JL, Schwarz RH, & Damus K. (2005) Estimated effect of 17 alpha-hydroxyprogesterone caproate on preterm birth in the United States. Obstetrics and gynecology, 105(2), 267-72. PMID: 15684150  

  • April 12, 2011
  • 08:00 AM

Suicide Gene Identified

by Shaheen Lakhan in Brain Blogger

Suicidal behavior is a leading cause of death and disability in the United States. Suicide is influenced by a variety of factors, including psychological, social, moral, political, and economic influences. Heredity has also been linked to suicidal thoughts and actions. Now, new evidence suggests that suicide attempt is linked to a specific gene. In 2007, [...]... Read more »

Crosby AE, Ortega L, Stevens MR, & Centers for Disease Control and Prevention (CDC). (2011) Suicides - United States, 1999-2007. MMWR. Surveillance summaries : Morbidity and mortality weekly report. Surveillance summaries / CDC, 56-9. PMID: 21430622  

Cui H, Supriyanto I, Sasada T, Shiroiwa K, Fukutake M, Shirakawa O, Asano M, Ueno Y, Nagasaki Y, & Hishimoto A. (2011) Association study of EP1 gene polymorphisms with suicide completers in the Japanese population. Progress in neuro-psychopharmacology . PMID: 21447366  

Mahon PB, Stütz AM, Seifuddin F, Huo Y, Goes FS, Jancic D, Judy JT, Depaulo JR Jr, Gershon ES, McMahon FJ.... (2010) Case-control association study of TGOLN2 in attempted suicide. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 153B(5), 1016-23. PMID: 20468057  

Perlis RH, Huang J, Purcell S, Fava M, Rush AJ, Sullivan PF, Hamilton SP, McMahon FJ, Schulze TG, Potash JB.... (2010) Genome-wide association study of suicide attempts in mood disorder patients. The American journal of psychiatry, 167(12), 1499-507. PMID: 21041247  

Serafini G, Pompili M, Innamorati M, Giordano G, Tatarelli R, Lester D, Girardi P, & Dwivedi Y. (2011) Glycosides, depression and suicidal behaviour: the role of glycoside-linked proteins. Molecules (Basel, Switzerland), 16(3), 2688-713. PMID: 21441870  

Willour VL, Seifuddin F, Mahon PB, Jancic D, Pirooznia M, Steele J, Schweizer B, Goes FS, Mondimore FM, Mackinnon DF.... (2011) A genome-wide association study of attempted suicide. Molecular psychiatry. PMID: 21423239  

Willour VL, Zandi PP, Badner JA, Steele J, Miao K, Lopez V, MacKinnon DF, Mondimore FM, Schweizer B, McInnis MG.... (2007) Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12. Biological psychiatry, 61(5), 725-7. PMID: 17046723  

  • April 6, 2011
  • 08:00 AM

Colic and Probiotics – A Cure for the Crying?

by Shaheen Lakhan in Brain Blogger

Colic is a syndrome that appears in up to 20% of infants. It is generally defined by a set of criteria in which a baby between the ages of 2 weeks and 16 weeks cries inconsolably for at least 3 hours a day for at least 3 days a week, lasting at least 3 weeks. [...]... Read more »

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