Vivek Misra

30 posts · 19,183 views

The UberBrain
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  • August 11, 2014
  • 09:38 AM
  • 105 views

Lithium For Aging Brain

by Vivek Misra in The UberBrain

Recent studies investigating Lithium, a drug commonly used for the treatment of mood disorders in humans, found its robust neurotrophic and neuroprotective effects which can help us exploring new novel, exciting, and promising targets. The molecular mechanism underlying lithium’s mood stabilizing effect is not yet unraveled. Suggested hypotheses include inositol-depletion via inhibition of inositol- monophosphatase and neuroprotection, via inhibition of GSK-3. Chronic lithium treatment inc........ Read more »

Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, & Manji HK. (2000) Enhancement of hippocampal neurogenesis by lithium. Journal of neurochemistry, 75(4), 1729-34. PMID: 10987856  

O'Brien WT, Harper AD, Jové F, Woodgett JR, Maretto S, Piccolo S, & Klein PS. (2004) Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(30), 6791-8. PMID: 15282284  

Berggren U, Tallstedt L, Ahlenius S, & Engel J. (1978) The effect of lithium on amphetamine-induced locomotor stimulation. Psychopharmacology, 59(1), 41-5. PMID: 100811  

Agam G, Bersudsky Y, Berry GT, Moechars D, Lavi-Avnon Y, & Belmaker RH. (2009) Knockout mice in understanding the mechanism of action of lithium. Biochemical Society transactions, 37(Pt 5), 1121-5. PMID: 19754464  

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS.... (2014) REST and stress resistance in ageing and Alzheimer's disease. Nature, 507(7493), 448-54. PMID: 24670762  

  • May 1, 2014
  • 01:22 PM
  • 274 views

Understanding Traumatic Brain Injury

by Vivek Misra in The UberBrain

Traumatic Brain Injury (TBI) is brain injury resulting from the application of an external physical force to the brain, including acceleration/deceleration and/or blast-related forces , that produce immediately apparent physiological disruption of brain function and/or structure, usually evidenced by an alteration of mental state and/or sensorimotor impairments, that result in at least transient functional disability. This definition of TBI excludes brain injuries due to perinatal trauma, hypoxi........ Read more »

Roozenbeek B, Maas AI, & Menon DK. (2013) Changing patterns in the epidemiology of traumatic brain injury. Nature reviews. Neurology, 9(4), 231-6. PMID: 23443846  

Silver JM, McAllister TW, & Arciniegas DB. (2009) Depression and cognitive complaints following mild traumatic brain injury. The American journal of psychiatry, 166(6), 653-61. PMID: 19487401  

Coronado VG, Xu L, Basavaraju SV, McGuire LC, Wald MM, Faul MD, Guzman BR, Hemphill JD, & Centers for Disease Control and Prevention (CDC). (2011) Surveillance for traumatic brain injury-related deaths--United States, 1997-2007. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002), 60(5), 1-32. PMID: 21544045  

  • April 18, 2014
  • 01:07 PM
  • 239 views

Overcomming Social Phobia with CBT and Pharmacotherapy

by Vivek Misra in The UberBrain

photo credit: ParadigmMalibu.comSocial phobia, a type of anxiety disorder, is characterized by persistent fear of one or more social or performance situations in which the person is exposed to unfamiliar people or to possible scrutiny by others (1). The individual fears that he or she will act in a way (or show anxiety symptoms) that will be embarrassing and humiliating.  Exposure to the feared situation almost invariably provokes anxiety, which may take the form of a situationally bou........ Read more »

Domschke K, Stevens S, Beck B, Baffa A, Hohoff C, Deckert J, & Gerlach AL. (2009) Blushing propensity in social anxiety disorder: influence of serotonin transporter gene variation. Journal of neural transmission (Vienna, Austria : 1996), 116(6), 663-6. PMID: 18629430  

Nahshoni E, Gur S, Marom S, Levin JB, Weizman A, & Hermesh H. (2004) QT dispersion in patients with social phobia. Journal of affective disorders, 78(1), 21-6. PMID: 14672793  

  • January 6, 2014
  • 04:48 PM
  • 256 views

Assistive Robots - Enhancing Quality of Life among People with Dementia

by Vivek Misra in The UberBrain

After obsessing over Captain Data and movies like iRobots, we always want to explore the possibility of having an Android in our home who help us in day-to-day work? Well robots maybe years away to do the housework, but they’re already helping out with senior citizens in nursing homes. PaPeRo: CharlieIn an exclusive event organized by Department of Foreign Affairs and Trade, Australian Consulate-General, today I had an opportunity to meet two such social robots Charlie and Sofie, designed........ Read more »

  • November 14, 2013
  • 01:53 PM
  • 429 views

Music Therapy: Hit Among Patients, Flopped on Tests

by Vivek Misra in The UberBrain

Power of Music by Louis Gallait.credits: wiki commonsApollo is the ancient Greek god of music and of medicine. Aesculapius was said to cure diseases of the mind by using song and music, and music therapy was used in Egyptian temples. But can be this actually be therapeutic in modern era?Music therapy is now being used in medical hospitals, cancer centers, schools, alcohol and drug recovery programs, psychiatric hospitals, and rehabilitation centers. It is thought of as a systematic int........ Read more »

  • September 26, 2013
  • 04:28 PM
  • 398 views

I Declare "No Conflict - No Interest" - Myth or Fact in Research

by Vivek Misra in The UberBrain

A conflict of interest (COI) occurs when an individual or organization is involved in multiple interests, one of which could possibly corrupt the motivation for an act in another.  Technology Incubators / Academic ties between physicians or medical researchers and pharmaceutical, medical device, and biotechnology companies can benefit society - most notably by promoting the discovery and development of new medications and medical devices that improve individual and public health. However so........ Read more »

Campbell EG, Weissman JS, Ehringhaus S, Rao SR, Moy B, Feibelmann S, & Goold SD. (2007) Institutional academic industry relationships. JAMA : the journal of the American Medical Association, 298(15), 1779-86. PMID: 17940234  

Campbell EG, Rao SR, DesRoches CM, Iezzoni LI, Vogeli C, Bolcic-Jankovic D, & Miralles PD. (2010) Physician professionalism and changes in physician-industry relationships from 2004 to 2009. Archives of internal medicine, 170(20), 1820-6. PMID: 21059976  

Brockway LM, Furcht LT, & FASEB. (2006) Conflicts of interest in biomedical research--the FASEB guidelines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20(14), 2435-8. PMID: 17142792  

  • August 10, 2013
  • 10:26 AM
  • 509 views

Beware of The Dementor's Kiss - Neuroinfection

by Vivek Misra in The UberBrain

Kissing is the second most common form of physical intimacy among United States adolescents (after holding hands), and that about 85% of 15 to 16-year-old adolescents in the US have experienced it. Kissing another person's lips has become a common expression of affection in many cultures worldwide. Being stereotype, its our nature to classify each and everything thing around us. So as “Kissing” into First Kiss, Last Kiss, Best Kiss and Worst Kiss and so on.  Well, I am not going to talk........ Read more »

Halpern CT, Joyner K, Udry JR, & Suchindran C. (2000) Smart teens don't have sex (or kiss much either). The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 26(3), 213-25. PMID: 10706169  

  • July 12, 2013
  • 01:53 AM
  • 528 views

How does the Brain Work ?

by Vivek Misra in The UberBrain

Following is the summary of First Neurokrish Lecture, which I have attended on 5th July 2013 Dr. French delivering the lecture.Photo: A Raja Chidamabaram | The Indian ExpressFree Will, Moral Action and Consciousness - can we explain these with our present knowledge of brain and mind ? Was the key question during the first Neurokrish Lecture.While delivering the Neurokrish Lecture 2013 titled "How does Brain Work", Dr. Chris French, a senior neurologist and epileptologist at the Royal Melbourne H........ Read more »

  • May 20, 2013
  • 01:23 PM
  • 458 views

Epilepsy Service Organization in Countries with Limited Resources

by Vivek Misra in The UberBrain

tumblr: bellapaige88On average, 9.5/1000 population has epilepsy in Low and Middle Income Countries (LAMIC). A research which has resulted in the global campaign against epilepsy has shown, the gap between treatment need and the treatment provision worldwide is approximately 70% [1]. This large ‘treatment gap’, i.e., lack of appropriate treatment for a large number of patients with epilepsy, due to a number of causes including inability to identify cases, inability to deliver adequate treatm........ Read more »

  • May 10, 2013
  • 02:41 AM
  • 494 views

Mitochondrial Disease – A Neurological Perspective

by Vivek Misra in The UberBrain

Defects of mitochondrial function have been identified in several neurodegenerative diseases. These include abnormalities induced by mutations of mitochondrial DNA (mtDNA) those caused by mutation of nuclear genes encoding mitochondrial proteins, and in some cases, exposure to mitochondrial toxins.MtDNA mutation are associated with a variety of progressive encephalomyopathies inn which there is evidence of neurodegeneration. These include  Kearns-Sayre syndrome myopathy, encephalopathy, lac........ Read more »

  • May 7, 2013
  • 12:19 PM
  • 623 views

"Insight" in Neuropsychiatric Disorders

by Vivek Misra in The UberBrain

photo:  jagaro.netLack of awareness of illness, poor insight or ‘denial’ are regarded as fundamental problems in neurology and psychiatry. The ‘object’ of the awareness differs in different conditions. For example a stroke patient may deny their hemiplegia (anosognosia) – a deficit which is visible and objective; a person with Alzheimer’s disease may be unaware of memory problems – which though measurable, are not readily apparent to the observer. Finally, a schizophrenic........ Read more »

Pijnenborg GH, van Donkersgoed RJ, David AS, & Aleman A. (2013) Changes in insight during treatment for psychotic disorders: a meta-analysis. Schizophrenia research, 144(1-3), 109-17. PMID: 23305612  

  • April 24, 2013
  • 02:58 AM
  • 466 views

Recent Trauma and Acute Infection Linked with Stroke In Children

by Vivek Misra in The UberBrain

Research has demonstrated that experiencing head or neck trauma or minor acute infections such as influenza can increase risk for stroke among adults. Inflammation in the CNS or in the periphery may be a risk factor for the initial development of cerebral ischemia. Fullerton (University of California, San Francisco, USA) and colleagues hypothesized that trauma and acute infections are independently associated with childhood arterial ischemic stroke (AIS). Researchers carried out a case........ Read more »

Emsley, H., & Tyrrell, P. (2002) Inflammation and Infection in Clinical Stroke. Journal of Cerebral Blood Flow , 1399-1419. DOI: 10.1097/00004647-200212000-00001  

Qureshi, A., Janssen, R., Karon, J., Weissman, J., Akbar, M., Safdar, K., & Frankel, M. (1997) Human Immunodeficiency Virus Infection and Stroke in Young Patients. Archives of Neurology, 54(9), 1150-1153. DOI: 10.1001/archneur.1997.00550210078016  

  • April 15, 2013
  • 03:27 PM
  • 377 views

Brain-to-Brain Interface - Share Information via Internet

by Vivek Misra in The UberBrain

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  • March 13, 2013
  • 02:40 AM
  • 1,019 views

Brain Lateralization - Logical Left vs Creative Right

by Vivek Misra in The UberBrain

Broad generalizations are often made in popular psychology about one side or the other having characteristic labels, such as "logical" for the left side or "creative" for the right. These labels need to be treated carefully; although a lateral dominance is measurable, both hemispheres contribute to both kinds of processes.In psychology and neurobiology, the theory is based on what is known as the lateralization of brain function. So does one side of the brain really control specific functions? A........ Read more »

George MS, Parekh PI, Rosinsky N, Ketter TA, Kimbrell TA, Heilman KM, Herscovitch P, & Post RM. (1996) Understanding emotional prosody activates right hemisphere regions. Archives of neurology, 53(7), 665-70. PMID: 8929174  

Dehaene, S., Piazza, M., Pinel, P., & Cohen, L. (2003) THREE PARIETAL CIRCUITS FOR NUMBER PROCESSING. Cognitive Neuropsychology, 20(3-6), 487-506. DOI: 10.1080/02643290244000239  

  • February 24, 2013
  • 05:23 PM
  • 561 views

Drugs, Dopamine and Drosophila: A Fly Model for ADHD?

by Vivek Misra in The UberBrain

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  • January 11, 2013
  • 10:31 AM
  • 454 views

“Gantenerumab” could pave way for Alzheimer's treatment

by Vivek Misra in The UberBrain

An experimental drug being developed by Roche Holding AG removed amyloid plaques from the brains of Alzheimer's disease patients in a small early-stage study, according to data published in the Archives of Neurology, Oct 10.Many researchers suspect the build-up of such plaques may be a cause of the memory robbing disease, although that theory has yet to be definitively proved.The next step will be to investigate whether removal of brain amyloid translates into clinical benefit for patients at do........ Read more »

Ostrowitzki, S., Deptula, D., Thurfjell, L., Barkhof, F., Bohrmann, B., Brooks, D., Klunk, W., Ashford, E., Yoo, K., Xu, Z.... (2011) Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab. Archives of Neurology, 69(2), 198-207. DOI: 10.1001/archneurol.2011.1538  

  • January 11, 2013
  • 10:14 AM
  • 575 views

"Alarm clock" gene explains wake-up function of biological clock

by Vivek Misra in The UberBrain

Tring Tring.....Wake Up...Its Morning...Mr. V :  I didn't set an alarm !!! whose this ???Ever wondered why you wake up in the morning—even when the alarm clock isn't making jarring noises? Researchers at the Salk Institute for Biological Studies have identified a new component of the biological clock, a gene responsible for starting the clock from its restful state every morning.The biological clock ramps up our metabolism early each day, initiating important physiological functions ........ Read more »

DiTacchio, L., Le, H., Vollmers, C., Hatori, M., Witcher, M., Secombe, J., & Panda, S. (2011) Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock. Science, 333(6051), 1881-1885. DOI: 10.1126/science.1206022  

  • January 11, 2013
  • 06:52 AM
  • 671 views

Is it the Type of Pencil or Really my Handwriting is Illegible !!!

by Vivek Misra in The UberBrain

It is quite obvious for a 4th grader to pass the buck for his/her bad handwriting. Recently, I came across some "real research articles" published in indexed journals addressing the same.Research indicates, it should be the type of pencil which should be blamed for legibility and speed in various writing task which include cursive writing, 10-min copy task, etc or maybe not !!!Conclusion 1: Results indicate that although the students in this study wrote more legibly on the short task t........ Read more »

Koziatek SM, & Powell NJ. (2003) Pencil grips, legibility, and speed of fourth-graders' writing in cursive. The American journal of occupational therapy : official publication of the American Occupational Therapy Association, 57(3), 284-8. PMID: 12785666  

Dennis JL, & Swinth Y. (2001) Pencil grasp and children's handwriting legibility during different-length writing tasks. The American journal of occupational therapy : official publication of the American Occupational Therapy Association, 55(2), 175-83. PMID: 11761133  

  • September 26, 2012
  • 03:51 AM
  • 741 views

HIV and Cognition: Indian Perspective

by Vivek Misra in The UberBrain

Dementia, as we all knows about it as an aging problem, which strikes the elderly people in society. When we look upon the Indian population, we can say that we are very young as 50% of our population is under forty years of age. As compared to developed countries, we have low prevalence and incidence rate of dementia.When we look upon neuro-infection and dementia, we find four major classes of neuro-infection related to dementia.1. Chronic Meningitis – Neurotuberculosis, fungal dementia, cryp........ Read more »

Hemelaar J, Gouws E, Ghys PD, Osmanov S, & WHO-UNAIDS Network for HIV Isolation and Characterisation. (2011) Global trends in molecular epidemiology of HIV-1 during 2000-2007. AIDS (London, England), 25(5), 679-89. PMID: 21297424  

Satishchandra P, Nalini A, Gourie-Devi M, Khanna N, Santosh V, Ravi V, Desai A, Chandramuki A, Jayakumar PN, & Shankar SK. (2000) Profile of neurologic disorders associated with HIV/AIDS from Bangalore, south India (1989-96). The Indian journal of medical research, 14-23. PMID: 10793489  

Gupta JD, Satishchandra P, Gopukumar K, Wilkie F, Waldrop-Valverde D, Ellis R, Ownby R, Subbakrishna DK, Desai A, Kamat A.... (2007) Neuropsychological deficits in human immunodeficiency virus type 1 clade C-seropositive adults from South India. Journal of neurovirology, 13(3), 195-202. PMID: 17613709  

Ranga U, Shankarappa R, Siddappa NB, Ramakrishna L, Nagendran R, Mahalingam M, Mahadevan A, Jayasuryan N, Satishchandra P, Shankar SK.... (2004) Tat protein of human immunodeficiency virus type 1 subtype C strains is a defective chemokine. Journal of virology, 78(5), 2586-90. PMID: 14963162  

  • September 4, 2012
  • 04:18 PM
  • 1,062 views

Neurocysticercosis - A Challenge for Developing Countries

by Vivek Misra in The UberBrain

Taenia solium. by Dr Frank GaillardCysticercosis of Brain or Neurocysticercosis is most common parasitic infection of the brain or central nervous system worldwide and the most common cause of adult onset epilepsy. The cause of human cysticercosis is the larval form of Taenia solium (pork tapeworm).Neurocysticercosis is more common in developing countries and is endemic in Mexico and Latin America, sub-Saharan Africa, India, and East Asia. According to WHO data there are 2,000,000 cases of the d........ Read more »

Sotelo J, & Del Brutto OH. (2000) Brain cysticercosis. Archives of medical research, 31(1), 3-14. PMID: 10767474  

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