1147 posts · 598,587 views
Autism research, research blogging and health science stuff (picture is accurate)
Contrary to the title of this post and any images that it may conjure up of mice parading down a runway in this season's 'hottest looks' whilst pouting to the clicks and flashes of multiple cameras, I'm back to mouse models and autism again(!) and an interesting piece of research by Hsiao and colleagues*.I am kinda standing on the shoulders of giants with this paper given that it comes from the laboratory of Paul Patterson who has already run with a short description about it on his blog (see he........ Read more »
Hsiao EY, McBride SW, Chow J, Mazmanian SK, & Patterson PH. (2012) Modeling an autism risk factor in mice leads to permanent immune dysregulation. Proceedings of the National Academy of Sciences of the United States of America. PMID: 22802640
I'm always been quite intrigued by studies examining the various behaviours linked to autism presenting in other conditions not necessarily linked to autism as a discrete entity. The various studies done on eating disorders* spring to mind as quite a good example.This type of research - when it shows some positive correlation - kinda reiterates that when we talk about autism, we aren't so much talking about a single homogeneous condition, but perhaps rather a range of conditions which share some........ Read more »
van Steensel FJ, Bögels SM, & Wood JJ. (2012) Autism Spectrum Traits in Children with Anxiety Disorders. Journal of autism and developmental disorders. PMID: 22733297
Sprouts, sprouts, sprouts @ WikipediaGlutathione in relation to autism spectrum conditions is a bit of a favourite topic of mine. I've talked about glutathione a few times on this blog (here and here) and how the various reports on a reduced level of functioning of this fantastic part of our antioxidant system seem to show more than a passing connection to cases of autism. That and the fact that consumption of a favourite foodstuff of mine, the Brussels sprout, might have quite a positive influe........ Read more »
Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE, & James SJ. (2012) Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Translational Psychiatry. PMID: 22781167
A blog post discussing the suggestion that a family history of schizophrenia and/or bipolar disorder may be a risk factor for autism... Read more »
Sullivan PF. et al. (2012) Family history of schizophrenia and bipolar disorder as risk factors for autism. Archives of General Psychiatry. DOI: 10.1001/archgenpsychiatry.2012.730
On the issue of the glutamate-glutamine ratio in cases of autism... Read more »
Abu Shmais GA, Al-Ayadhi LY, Al-Dbass AM, & El-Ansary AK. (2012) Mechanism of nitrogen metabolism-related parameters and enzyme activities in the pathophysiology of autism. Journal of neurodevelopmental disorders, 4(1), 4. PMID: 22958401
Elevated lactate levels seem to be a feature of some cases of autism... Read more »
Oliveira, G., Diogo, L., Grazina, M., Garcia, P., Psych, A., Marques, C., Miguel, T., Borges, L., Vicente, A., & Oliveira, C. (2007) Mitochondrial dysfunction in autism spectrum disorders: a population-based study. Developmental Medicine , 47(3), 185-189. DOI: 10.1111/j.1469-8749.2005.tb01113.x
The first report on the identification of Sutterella spp following analysis of gut bacteria from children with autism... Read more »
Williams BL, Hornig M, Parekh T, & Lipkin WI. (2012) Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. mBio, 3(1). PMID: 22233678
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