Ovarian cancer is the most lethal gynecologic malignancy. After epigenomic analysis of patient tumors, aberrant DNA methylation patterns are universally observed in the most abundant histological subtype of ovarian cancer, high-grade serous ovarian cancer (HGSOC). These epigenetic modifications like DNA methylation are known to frequently affect gene regulation involved in cancer-related processes. Since epigenetic alterations are reversible in nature, these changes have emerged as attractive ta........ Read more »
Tomar T, de Jong S, Alkema NG, Hoekman RL, Meersma GJ, Klip HG, van der Zee AG, & Wisman GB. (2016) Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways. Genome medicine, 8(1), 107. PMID: 27765068
Alkema NG, Wisman GB, van der Zee AG, van Vugt MA, & de Jong S. (2016) Studying platinum sensitivity and resistance in high-grade serous ovarian cancer: Different models for different questions. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 55-69. PMID: 26830315
Hidalgo M, Amant F, Biankin AV, Budinská E, Byrne AT, Caldas C, Clarke RB, de Jong S, Jonkers J, Mælandsmo GM.... (2014) Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer discovery, 4(9), 998-1013. PMID: 25185190
Alkema NG, Tomar T, Duiker EW, Jan Meersma G, Klip H, van der Zee AG, Wisman GB, & de Jong S. (2015) Biobanking of patient and patient-derived xenograft ovarian tumour tissue: efficient preservation with low and high fetal calf serum based methods. Scientific reports, 14495. PMID: 26440065
Apolipoprotein A5 gene (APOA5) is one of the genes implicated in contributing to a predisposition for hypertriacylglycerolaemia (HTG), a complex polygenic pathology that is highly influenced by environment. Hypertriacylglycerolaemia is characterized by having high circulating triacylglycerol levels and is a significant risk factor for cardiovascular disease and atherosclerosis. This genetic predisposition has an inherited component (based on polymorphisms) as well as an acquired component regu........ Read more »
Oliva, I., Guardiola, M., Vallve, J., Ibarretxe, D., Plana, N., Masana, L., Monk, D., & Ribalta, J. (2016) APOA5 genetic and epigenetic variability jointly regulate circulating triacylglycerol levels. Clinical Science, 130(22), 2053-2059. DOI: 10.1042/CS20160433
DNA methylation is a biological clock that ticks with age, and numerous studies have been able to construct age-prediction models based on methylation status. However in somatic cells, DNA methylation is highly polymorphic – though this is not always appreciated in genome wide studies because coverage is often limited and variants below 10% usually escape detection. In an effort to clarify the origin of somatic DNA methylation heterogeneity and the impact it has on chromatin domains and ge........ Read more »
Russo, G., Landi, R., Pezone, A., Morano, A., Zuchegna, C., Romano, A., Muller, M., Gottesman, M., Porcellini, A., & Avvedimento, E. (2016) DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism. Scientific Reports, 33222. DOI: 10.1038/srep33222
Cuozzo, C., Porcellini, A., Angrisano, T., Morano, A., Lee, B., Pardo, A., Messina, S., Iuliano, R., Fusco, A., Santillo, M.... (2007) DNA Damage, Homology-Directed Repair, and DNA Methylation. PLoS Genetics, 3(7). DOI: 10.1371/journal.pgen.0030110
Morano, A., Angrisano, T., Russo, G., Landi, R., Pezone, A., Bartollino, S., Zuchegna, C., Babbio, F., Bonapace, I., Allen, B.... (2013) Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene. Nucleic Acids Research, 42(2), 804-821. DOI: 10.1093/nar/gkt920
Landan, G., Cohen, N., Mukamel, Z., Bar, A., Molchadsky, A., Brosh, R., Horn-Saban, S., Zalcenstein, D., Goldfinger, N., Zundelevich, A.... (2012) Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues. Nature Genetics, 44(11), 1207-1214. DOI: 10.1038/ng.2442
Estradiol (E2) influences a number of processes that are important for maintaining healthy brain function, including memory. The ability of E2 to protect the brain and enhance or maintain memory function depends on the interaction of E2 with different estrogen receptors.1 In particular, the expression of estrogen receptor alpha (ERα) has been linked to synaptic plasticity, inflammation, and neuroprotection.2-5 Thus, it may be important that expression of ERα in the hippocampus, a bra........ Read more »
Ianov L, Kumar A, & Foster TC. (2016) Epigenetic regulation of estrogen receptor α contributes to age-related differences in transcription across the hippocampal regions CA1 and CA3. Neurobiology of aging, 79-85. PMID: 27776265
Bean LA, Ianov L, & Foster TC. (2014) Estrogen receptors, the hippocampus, and memory. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 20(5), 534-45. PMID: 24510074
Adams MM, Fink SE, Shah RA, Janssen WG, Hayashi S, Milner TA, McEwen BS, & Morrison JH. (2002) Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(9), 3608-14. PMID: 11978836
Benedusi V, Meda C, Della Torre S, Monteleone G, Vegeto E, & Maggi A. (2012) A lack of ovarian function increases neuroinflammation in aged mice. Endocrinology, 153(6), 2777-88. PMID: 22492304
Merchenthaler I, Dellovade TL, & Shughrue PJ. (2003) Neuroprotection by estrogen in animal models of global and focal ischemia. Annals of the New York Academy of Sciences, 89-100. PMID: 14993043
Zhang QG, Raz L, Wang R, Han D, De Sevilla L, Yang F, Vadlamudi RK, & Brann DW. (2009) Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(44), 13823-36. PMID: 19889994
Bean LA, Kumar A, Rani A, Guidi M, Rosario AM, Cruz PE, Golde TE, & Foster TC. (2015) Re-Opening the Critical Window for Estrogen Therapy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(49), 16077-93. PMID: 26658861
Zhang QG, Han D, Wang RM, Dong Y, Yang F, Vadlamudi RK, & Brann DW. (2011) C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America, 108(35). PMID: 21808025
Han X, Aenlle KK, Bean LA, Rani A, Semple-Rowland SL, Kumar A, & Foster TC. (2013) Role of estrogen receptor α and β in preserving hippocampal function during aging. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(6), 2671-83. PMID: 23392694
Cancer metastasis occurs when cancer cells leave a primary tumor and invade other tissues. Generally, this leads to a poor prognosis for patients. Underlying epigenetic mechanisms of tumor progression are poorly understood but are of great interest for developing new approaches of treatment in the clinic. Cancer etiology is highly correlated with alterations in the histone code1-5 and protein methyltransferases are frequently dysregulated in cancer, implicating them as compelling novel targets f........ Read more »
Chen H, Lorton B, Gupta V, & Shechter D. (2016) A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression. Oncogene. PMID: 27270440
Chi P, Allis CD, & Wang GG. (2010) Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nature reviews. Cancer, 10(7), 457-69. PMID: 20574448
Stopa N, Krebs JE, & Shechter D. (2015) The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond. Cellular and molecular life sciences : CMLS, 72(11), 2041-59. PMID: 25662273
Cha B, & Jho EH. (2012) Protein arginine methyltransferases (PRMTs) as therapeutic targets. Expert opinion on therapeutic targets, 16(7), 651-64. PMID: 22621686
Yang XJ, & Seto E. (2008) Lysine acetylation: codified crosstalk with other posttranslational modifications. Molecular cell, 31(4), 449-61. PMID: 18722172
Greenblatt SM, Liu F, & Nimer SD. (2016) Arginine methyltransferases in normal and malignant hematopoiesis. Experimental hematology, 44(6), 435-41. PMID: 27026282
Wilczek C, Chitta R, Woo E, Shabanowitz J, Chait BT, Hunt DF, & Shechter D. (2011) Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs. The Journal of biological chemistry, 286(49), 42221-31. PMID: 22009756
Ho MC, Wilczek C, Bonanno JB, Xing L, Seznec J, Matsui T, Carter LG, Onikubo T, Kumar PR, Chan MK.... (2013) Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity. PloS one, 8(2). PMID: 23451136
Burgos ES, Wilczek C, Onikubo T, Bonanno JB, Jansong J, Reimer U, & Shechter D. (2015) Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase. The Journal of biological chemistry, 290(15), 9674-89. PMID: 25713080
Chan-Penebre E, Kuplast KG, Majer CR, Boriack-Sjodin PA, Wigle TJ, Johnston LD, Rioux N, Munchhof MJ, Jin L, Jacques SL.... (2015) A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nature chemical biology, 11(6), 432-7. PMID: 25915199
Liu F, Cheng G, Hamard PJ, Greenblatt S, Wang L, Man N, Perna F, Xu H, Tadi M, Luciani L.... (2015) Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. The Journal of clinical investigation, 125(9), 3532-44. PMID: 26258414
Ikushima H, & Miyazono K. (2010) TGFbeta signalling: a complex web in cancer progression. Nature reviews. Cancer, 10(6), 415-24. PMID: 20495575
Lamouille, S., Xu, J., & Derynck, R. (2014) Molecular mechanisms of epithelial–mesenchymal transition. Nature Reviews Molecular Cell Biology, 15(3), 178-196. DOI: 10.1038/nrm3758
DNA methylation and hydroxymethylation are well-established key players in gene regulation. Although many would agree that 5hmC also plays a critical role, there is still some debate over whether it serves a functional role, or is merely an artifact of DNA de-methylation. Even still, other intermediates of de-methylation are actively being investigated. In a recent paper by Iuilaro et al. 2016, a group of scientists argue that 5-formlycytosine (5fC), an intermediate of DNA de-methylation, is a s........ Read more »
Iurlaro M, McInroy GR, Burgess HE, Dean W, Raiber EA, Bachman M, Beraldi D, Balasubramanian S, & Reik W. (2016) In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine. Genome biology, 17(1), 141. PMID: 27356509
Aneuploidy is the leading cause of miscarriage, stillbirth, and congenital birth defects and occurs as a result of errors during meiotic or mitotic cell division.1 As a woman ages, the probability of an aneuploid conception significantly rises, to roughly 50% by the age of 40.2 Only a fraction of full aneuploidies, primarily trisomies, will develop past the first trimester. This is in contrast to monosomies that almost never implant or result in an ongoing pregnancy. DNA methylation is an epi........ Read more »
McCallie BR, Parks JC, Patton AL, Griffin DK, Schoolcraft WB, & Katz-Jaffe MG. (2016) Hypomethylation and Genetic Instability in Monosomy Blastocysts May Contribute to Decreased Implantation Potential. PloS one, 11(7). PMID: 27434648
Hassold T, Hall H, & Hunt P. (2007) The origin of human aneuploidy: where we have been, where we are going. Human molecular genetics. PMID: 17911163
Grewal, S. (2003) Heterochromatin and Epigenetic Control of Gene Expression. Science, 301(5634), 798-802. DOI: 10.1126/science.1086887
Messerschmidt DM, Knowles BB, & Solter D. (2014) DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos. Genes , 28(8), 812-28. PMID: 24736841
Kahlem, P. (2004) Transcript Level Alterations Reflect Gene Dosage Effects Across Multiple Tissues in a Mouse Model of Down Syndrome. Genome Research, 14(7), 1258-1267. DOI: 10.1101/gr.1951304
Human papillomaviruses (HPV) are a diverse group of small double-stranded DNA viruses with specific mucosal or cutaneous tropisms. It is estimated that up to 80% of sexually active individuals will become infected with HPV sometime in their lifetime, making HPV the most prevalent sexually transmitted infection. HPVs can be further divided into high- and low-risk genotypes, based on their oncogenic potential. High-risk HPVs are implicated as causal in nearly 100% of cervical cancers, approximatel........ Read more »
Cicchini L, Westrich JA, Xu T, Vermeer DW, Berger JN, Clambey ET, Lee D, Song JI, Lambert PF, Greer RO.... (2016) Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14. mBio, 7(3). PMID: 27143385
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Anayannis NV, Schlecht NF, & Belbin TJ. (2015) Epigenetic Mechanisms of Human Papillomavirus-Associated Head and Neck Cancer. Archives of pathology , 139(11), 1373-8. PMID: 25978766
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A nucleosome is constituted by positively charged histone proteins and negatively charged DNA. Methylation as well as other covalent modifications on DNA and histones ( together also called epigenetic modifications or marks) play important roles in the regulation of chromatin structure and function. TET (Ten-Eleven Translocation) proteins were identified as 5mC oxidases which not only generate new 5mC oxidative derivates (5hmC, 5caC and 5fC) but also initiate active or passive DNA demethylation1........ Read more »
Kong L, Tan L, Lv R, Shi Z, Xiong L, Wu F, Rabidou K, Smith M, He C, Zhang L.... (2016) A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands. Nucleic acids research. PMID: 27288448
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L.... (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (New York, N.Y.), 324(5929), 930-5. PMID: 19372391
He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L.... (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (New York, N.Y.), 333(6047), 1303-7. PMID: 21817016
Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, & Zhang Y. (2011) Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (New York, N.Y.), 333(6047), 1300-3. PMID: 21778364
Zhang, H., Zhang, X., Clark, E., Mulcahey, M., Huang, S., & Shi, Y. (2010) TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine. Cell Research, 20(12), 1390-1393. DOI: 10.1038/cr.2010.156
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Easwaran H, Johnstone SE, Van Neste L, Ohm J, Mosbruger T, Wang Q, Aryee MJ, Joyce P, Ahuja N, Weisenberger D.... (2012) A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome research, 22(5), 837-49. PMID: 22391556
Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q.... (2012) Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell, 150(6), 1135-46. PMID: 22980977
Tan L, & Shi YG. (2012) Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development (Cambridge, England), 139(11), 1895-902. PMID: 22569552
Phenotypic differences between males and females of a species are referred to as sexual dimorphism. Sexual dimorphism manifests not only in morphological traits, but also in physiological and behavioural traits. In organisms that do not have sex chromosomes, males and females are both derived from a nearly identical genome. Such is the case in zebrafish. Despite being such an important model for biological research, the mechanism of sex determination still remains a mystery. Many believe environ........ Read more »
Chatterjee, A., Lagisz, M., Rodger, E., Zhen, L., Stockwell, P., Duncan, E., Horsfield, J., Jeyakani, J., Mathavan, S., Ozaki, Y.... (2016) Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended ‘male sex drive’ hypothesis. Gene. DOI: 10.1016/j.gene.2016.05.042
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Chatterjee A, Stockwell PA, Horsfield JA, Morison IM, & Nakagawa S. (2014) Base-resolution DNA methylation landscape of zebrafish brain and liver. Genomics data, 342-4. PMID: 26484126
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Mice born to alcohol exposed fathers were resistant to stress-induced drinking. Read more on today's EpiBeat!... Read more »
Rompala GR, Finegersh A, & Homanics GE. (2016) Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice. Alcohol (Fayetteville, N.Y.), 19-25. PMID: 27286933
Parkinson’s disease (PD) is the second most frequent neurodegenerative disease, affecting 1-2% of the population over 55 years of age. The main pathological feature of PD is the progressive death of neurons located in the midbrain that produce the neurotransmitter dopamine. These neurons modulate the activity of a collection of ...
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Södersten E, Feyder M, Lerdrup M, Gomes AL, Kryh H, Spigolon G, Caboche J, Fisone G, & Hansen K. (2014) Dopamine signaling leads to loss of polycomb repression and aberrant gene activation in experimental parkinsonism. PLoS genetics, 10(9). PMID: 25254549
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Feyder M, Södersten E, Santini E, Vialou V, LaPlant Q, Watts EL, Spigolon G, Hansen K, Caboche J, Nestler EJ.... (2014) A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression. Biological psychiatry. PMID: 25193242
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Epigenetics refers to changes in gene regulation that are do not related to changes in the primary sequence of DNA. It can be reversible and heritable throughout cell division, and its regulation is characterized by several modifications, such as DNA methylation and post-translational changes in the histone proteins. In addition, ...
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Franco MM, Prickett AR, & Oakey RJ. (2014) The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting, Development, and Reproduction. Biology of reproduction. PMID: 25297545
Franco MM, Fagundes NS, Michalczechen-Lacerda VA, Caixeta ES, de Castro Rodrigues F, Machado GM, Ferreira AR, & Dode MA. (2014) Characterisation of the methylation pattern in the intragenic CpG island of the IGF2 gene in Bos taurus indicus cumulus cells during in vitro maturation. Journal of assisted reproduction and genetics, 31(1), 115-20. PMID: 24174298
Carvalho JO, Michalczechen-Lacerda VA, Sartori R, Rodrigues FC, Bravim O, Franco MM, & Dode MA. (2012) The methylation patterns of the IGF2 and IGF2R genes in bovine spermatozoa are not affected by flow-cytometric sex sorting. Molecular reproduction and development, 79(2), 77-84. PMID: 22128039
Fagundes NS, Michalczechen-Lacerda VA, Caixeta ES, Machado GM, Rodrigues FC, Melo EO, Dode MA, & Franco MM. (2011) Methylation status in the intragenic differentially methylated region of the IGF2 locus in Bos taurus indicus oocytes with different developmental competencies. Molecular human reproduction, 17(2), 85-91. PMID: 20833870
Aberrant epigenetic status resulting in dysregulation of gene expression is a hallmark of many cancers and other diseases. In the last decade, countless time and energy has been spent in efforts to develop drugs targeting DNA methylation and histone modifications. To date however, none of these epigenetic drugs are sequence ...
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Grimmer MR, Stolzenburg S, Ford E, Lister R, Blancafort P, & Farnham PJ. (2014) Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation. Nucleic acids research, 42(16), 10856-68. PMID: 25122745
More than 35% of the U.S. population is considered clinically obese (body mass index of > 30), while 68% of the U.S. is considered overweight (body mass index of > 25) 1. Obesity is known to have adverse health effects, impacting the risk and prognosis for a number of diseases, ...
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Ogden CL, Carroll MD, Kit BK, & Flegal KM. (2014) Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA, 311(8), 806-14. PMID: 24570244
Hu FB. (2011) Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes care, 34(6), 1249-57. PMID: 21617109
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Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, Rodford J, Slater-Jefferies JL, Garratt E, Crozier SR.... (2011) Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes, 60(5), 1528-34. PMID: 21471513
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Schuster-Böckler, B., & Lehner, B. (2012) Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature, 488(7412), 504-507. DOI: 10.1038/nature11273
Atherosclerosis is an inflammatory disease of the arterial walls, and is the major cause of heart attack and stroke. Atherosclerosis is localized to curves and branches in the vasculature where disturbed blood flow (d-flow) is able to alter gene expression and induce endothelial cell (EC) dysfunction. Our lab’s work focuses on the mechanism by which ...
The post Endothelial DNA Methylation Goes With the Flow appeared first on EpiBeat.
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Dunn J, Qiu H, Kim S, Jjingo D, Hoffman R, Kim CW, Jang I, Son DJ, Kim D, Pan C.... (2014) Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. The Journal of clinical investigation. PMID: 24865430
Nam D, Ni CW, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison D, Giddens D, & Jo H. (2009) Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. American journal of physiology. Heart and circulatory physiology, 297(4). PMID: 19684185
Ni CW, Qiu H, Rezvan A, Kwon K, Nam D, Son DJ, Visvader JE, & Jo H. (2010) Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow. Blood, 116(15). PMID: 20551377
Gerhard A. Coetzee, Wange Lu, Peggy Farnham USC Genome-wide association studies (GWAS) have revealed numerous single-nucleotide polymorphisms (SNPs) where allelic frequencies differ between cases and controls of many complex diseases (NHGRI GWA Catalog). In the last decade 6,696 genetic associations of 598 traits have been reported in 16,770 papers (up to 2013). Despite these impressive ...
The post SNP-SNP here, SNP-SNP there, everywhere a SNP-SNP, old McDonald had a GWAS…… appeared first o........ Read more »
Hazelett DJ, Rhie SK, Gaddis M, Yan C, Lakeland DL, Coetzee SG, Ellipse/GAME-ON consortium, Practical consortium, Henderson BE, Noushmehr H.... (2014) Comprehensive functional annotation of 77 prostate cancer risk loci. PLoS genetics, 10(1). PMID: 24497837
Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S.... (2013) Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature genetics, 45(4), 385. PMID: 23535732
Coetzee SG, Rhie SK, Berman BP, Coetzee GA, & Noushmehr H. (2012) FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs. Nucleic acids research, 40(18). PMID: 22684628
The mitochondria, often referred to as the “power-house” of the cell, provide a platform for energy production through glucose metabolism. As a bi-product of this, they also are the major producer of reactive oxidative species. Mitochondria also play other important physiological roles, such as calcium homeostasis and aid in the regulation of cell death through ...
The post The Mitochondrial Epigenetic Revolution: A New Avenue for Potential Research appeared first on EpiBeat.
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Chestnut BA, Chang Q, Price A, Lesuisse C, Wong M, & Martin LJ. (2011) Epigenetic regulation of motor neuron cell death through DNA methylation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(46), 16619-36. PMID: 22090490
Manev H, Dzitoyeva S, & Chen H. (2012) Mitochondrial DNA: A Blind Spot in Neuroepigenetics. Biomolecular concepts, 3(2), 107-115. PMID: 22639700
Shock LS, Thakkar PV, Peterson EJ, Moran RG, & Taylor SM. (2011) DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 108(9), 3630-5. PMID: 21321201
Wong M, Gertz B, Chestnut BA, & Martin LJ. (2013) Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS. Frontiers in cellular neuroscience, 279. PMID: 24399935
Tamoxifen and aromatase inhibitors (AIs) are both treatment options for patients with breast tumors that express estrogen receptor (ER) α and that require estrogen for growth. Tamoxifen competes with estrogen in binding to the ER, but does not activate the receptor. In comparison, AIs lower estrogen levels in the body by blocking the conversion of ...The post The Battle for HOXC10 in the War Against Breast Cancer appeared first on EpiBeat.... Read more »
Pathiraja TN, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ.... (2014) Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer. Science translational medicine, 6(229). PMID: 24670685
The discovery of induced pluripotent stem cells (iPSCs) and the creation of clinically relevant cell types derived from them, have been great leaps toward the implementation of stem cell based therapies and disease models. But in recent years, concerns have risen about iPSCs “remembering” their original cell types and favoring differentiation towards their origins. This ...The post iPSC Epigenetic Memory: One more Roadblock for Regenerative Medicine? appeared first on EpiBeat.... Read more »
Roessler R, Smallwood SA, Veenvliet JV, Pechlivanoglou P, Peng SP, Chakrabarty K, Groot-Koerkamp MJ, Pasterkamp RJ, Wesseling E, Kelsey G.... (2014) Detailed Analysis of the Genetic and Epigenetic Signatures of iPSC-Derived Mesodiencephalic Dopaminergic Neurons. Stem cell reports, 2(4), 520-33. PMID: 24749075
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