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Biólogo e estudade de doutorado em Evolução do vírus HIV na USP. Community leader do ScienceBlogs Brasil e editor do Research Blogging em português.
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- June 24, 2009
- 03:46 PM
- 1,133 views
The miracle of the falling cat
by Atila in Brazillion Thoughts
A cat fell from the 26th floor in New York. What happened to the kitten? Nothing.Source.
The name of the cat is Lucky. Of course, with a name like that, it was no surprise that a miracle saved him. According to the owner:
"That's the thing about Lucky Miraculous," HOSTETLER told "GMA." "He has been [lucky] since we got him." Source
NOT!
If the cat was really lucky, would it fall from the window? Does every miracle requires something bad happening before?Actually, the cat would be more lucky ........ Read more »
Diamond, J. (1988) Why cats have nine lives. Nature, 332(6165), 586-587. DOI: 10.1038/332586a0
- June 8, 2009
- 11:25 PM
- 965 views
Pulgões e o poder dos clones
by Atila in Rainha Vermelha
Devido ao parentesco gerado pela clonagem, o suicídio é uma estratégia eficiente de defesa entre pulgões.... Read more »
Kutsukake, M., Shibao, H., Uematsu, K., & Fukatsu, T. (2009) Scab formation and wound healing of plant tissue by soldier aphid. Proceedings of the Royal Society B: Biological Sciences, 276(1662), 1555-1563. DOI: 10.1098/rspb.2008.1628
Kazana, E., Pope, T., Tibbles, L., Bridges, M., Pickett, J., Bones, A., Powell, G., & Rossiter, J. (2007) The cabbage aphid: a walking mustard oil bomb. Proceedings of the Royal Society B: Biological Sciences, 274(1623), 2271-2277. DOI: 10.1098/rspb.2007.0237
- September 10, 2009
- 09:21 PM
- 851 views
Molecule of the month presents: Hemagglutinin and Neuramidase
by Atila Iamarino in Influenza A (H1N1) Blog – English
Molecule of the month is an initiative of the RCSB PDB (A Resource for Studying Biological Macromolecules – Protein Data Bank) a protein structure bank. Every month, David Goodsell chooses an interesting structure and describes it, besides illustrating it very well. The illustrations are made available in a high resolution image that may be downloaded.
Goodsell [...]... Read more »
Wiley, D., & Skehel, J. (1987) The Structure and Function of the Hemagglutinin Membrane Glycoprotein of Influenza Virus. Annual Review of Biochemistry, 56(1), 365-394. DOI: 10.1146/annurev.bi.56.070187.002053
Skehel, J., & Wiley, D. (2000) RECEPTOR BINDING AND MEMBRANE FUSION IN VIRUS ENTRY: The Influenza Hemagglutinin. Annual Review of Biochemistry, 69(1), 531-569. DOI: 10.1146/annurev.biochem.69.1.531
Colman, P., Varghese, J., & Laver, W. (1983) Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature, 303(5912), 41-44. DOI: 10.1038/303041a0
- June 4, 2009
- 07:26 AM
- 843 views
Sobre besouros chifrudos
by Atila in Rainha Vermelha
Os lindos resultados da batalha por sexo e o surgimento dos chifres dos besouros.... Read more »
Emlen, D., Corley Lavine, L., & Ewen-Campen, B. (2007) Colloquium Papers: On the origin and evolutionary diversification of beetle horns. Proceedings of the National Academy of Sciences, 104(suppl_1), 8661-8668. DOI: 10.1073/pnas.0701209104
Moczek, A., & Rose, D. (2009) From the Cover: Differential recruitment of limb patterning genes during development and diversification of beetle horns. Proceedings of the National Academy of Sciences, 106(22), 8992-8997. DOI: 10.1073/pnas.0809668106
- June 21, 2009
- 04:30 PM
- 815 views
Deforestation does not lead to development
by Atila in Brazillion Thoughts
Science magazine has published a paper that is extremely important for the Brazilian Amazon. Brazilian researchers (IMAZON), in collaboration with researchers from other nations, evaluated the impact of the deforestation in the social and economic development in the affected Amazonian towns. The paper starts with some pretty impressive numbers: this country has 40% of the remaining tropical forests in the world. However, between 1998 and 2008, we took our forest down at a rate of 1,8 million ha/........ Read more »
Rodrigues, A., Ewers, R., Parry, L., Souza, C., Verissimo, A., & Balmford, A. (2009) Boom-and-Bust Development Patterns Across the Amazon Deforestation Frontier. Science, 324(5933), 1435-1437. DOI: 10.1126/science.1174002
- June 15, 2009
- 10:06 PM
- 795 views
Varíola, uma das maiores pandemias da história
by Atila in Rainha Vermelha
A varíola tem sintomas parecidos com o da gripe, que em cerca de 12 dias evoluem para vômitos, náuseas e, no fim, infecção generalizada da pele, onde causa bolhas ou pústulas, que deixam grandes cicatrizes chamadas bexigas. Daí o nome, varius em latim significa manchado. Mata de 20 a 60% dos infectados e, na maioria dos casos, deixa os sobreviventes marcados para o resto da vida.Ela é causada por um vírus transmissível pelo ar. O vírus da varíola é um vírus de DNA, um dos maiores v........ Read more »
Nicolau Barquet, & Pere Domingo. (1997) Smallpox: The Triumph over the Most Terrible of the Ministers of Death. Ann Intern Med, 127(8), 635-642. DOI: http://www.annals.org/cgi/content/abstract/127/8_Part_1/635
- September 8, 2009
- 10:46 AM
- 792 views
Why do we fear influenza 2 – the virus
by Atila Iamarino in Influenza A (H1N1) Blog – English
In the previous text, I addressed why it is difficult to develop antivirals, here we will understand the characteristics of the influenza virus that worries us.
Where do viruses come from and what makes them more or less dangerous?
The virus that infects us may already be with us during our evolutive history, [...]... Read more »
Wolfe, N., Dunavan, C., & Diamond, J. (2007) Origins of major human infectious diseases. Nature, 447(7142), 279-283. DOI: 10.1038/nature05775
Carrat, F., Vergu, E., Ferguson, N., Lemaitre, M., Cauchemez, S., Leach, S., & Valleron, A. (2008) Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies. American Journal of Epidemiology, 167(7), 775-785. DOI: 10.1093/aje/kwm375
- October 21, 2009
- 10:01 PM
- 788 views
Antiviral and resistance: sialidase inhibitors
by Atila Iamarino in Influenza A (H1N1) Blog – English
From adamantine therapeutics failures, interest in developing new drugs against the flu virus had come up. Hence, appeared oseltamivir and zanamivir, neuraminidase inhibitors, the first class of planned drugs against Influenza. Here, the path taken for their production was reverse of that of amantadine. Instead of testing the drug and finding out later how [...]... Read more »
von Itzstein, M., Wu, W., Kok, G., Pegg, M., Dyason, J., Jin, B., Phan, T., Smythe, M., White, H., Oliver, S.... (1993) Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature, 363(6428), 418-423. DOI: 10.1038/363418a0
Hata, K., Koseki, K., Yamaguchi, K., Moriya, S., Suzuki, Y., Yingsakmongkon, S., Hirai, G., Sodeoka, M., von Itzstein, M., & Miyagi, T. (2008) Limited Inhibitory Effects of Oseltamivir and Zanamivir on Human Sialidases. Antimicrobial Agents and Chemotherapy, 52(10), 3484-3491. DOI: 10.1128/AAC.00344-08
De Clercq, E. (2006) Antiviral agents active against influenza A viruses. Nature Reviews Drug Discovery, 5(12), 1015-1025. DOI: 10.1038/nrd2175
Collins, P., Haire, L., Lin, Y., Liu, J., Russell, R., Walker, P., Skehel, J., Martin, S., Hay, A., & Gamblin, S. (2008) Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature, 453(7199), 1258-1261. DOI: 10.1038/nature06956
Hurt, A., Holien, J., Parker, M., Kelso, A., & Barr, I. (2009) Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation. Journal of Virology, 83(20), 10366-10373. DOI: 10.1128/JVI.01200-09
, . (2009) Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans. New England Journal of Medicine, 360(25), 2605-2615. DOI: 10.1056/NEJMoa0903810
Soundararajan, V., Tharakaraman, K., Raman, R., Raguram, S., Shriver, Z., Sasisekharan, V., & Sasisekharan, R. (2009) Extrapolating from sequence—the 2009 H1N1 'swine' influenza virus. Nature Biotechnology, 27(6), 510-513. DOI: 10.1038/nbt0609-510
- May 19, 2009
- 12:21 AM
- 783 views
De onde vêm as doenças infecciosas
by Atila in Rainha Vermelha
Como adquirimos grande parte de nossas doenças infecciosas de primatas e animais de criação ao longo de nossa evolução.... Read more »
Wolfe, N., Dunavan, C., & Diamond, J. (2007) Origins of major human infectious diseases. Nature, 447(7142), 279-283. DOI: 10.1038/nature05775
- May 12, 2009
- 04:48 PM
- 777 views
Sobre macacos pelados
by Atila in Rainha Vermelha
Parasitas possivelmente foram o motivo por trás da nossa perda de pêlos, durante a evolução da linhagem humana. E eles nos mostram também quando passamos a nos vestir.... Read more »
Rantala, M. (2007) Evolution of nakedness in Homo sapiens. Journal of Zoology, 273(1), 1-7. DOI: 10.1111/j.1469-7998.2007.00295.x
Kittler, R., Kayser, M., & Stoneking, M. (2003) Molecular Evolution of Pediculus humanus and the Origin of Clothing. Current Biology, 13(16), 1414-1417. DOI: 10.1016/S0960-9822(03)00507-4
- October 26, 2009
- 02:17 PM
- 739 views
Para o lado errado: A síndrome de Kartagener
by Atila in Rainha Vermelha
Conforme os muitos comentários, e todos certos, a relação entre todos aqueles sintomas está na Síndrome de Kartagener! Meus parabéns, a galera me destruiu.
Epitélio do brônquio com células ciliares. Fonte: Wikimedia.A Síndrome de Kartagener é uma doença genética realmente curiosa.
Recessiva, ela só ocorre nos que herdam ambos os alelos (de pai e de
mãe) com a característica, geralmente um defeito na proteína dineína. E por que seus portadores tem menos olfato,
menos audição........ Read more »
Zariwala, M., Knowles, M., & Omran, H. (2007) Genetic Defects in Ciliary Structure and Function. Annual Review of Physiology, 69(1), 423-450. DOI: 10.1146/annurev.physiol.69.040705.141301
Nonaka, S., Yoshiba, S., Watanabe, D., Ikeuchi, S., Goto, T., Marshall, W., & Hamada, H. (2005) De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia. PLoS Biology, 3(8). DOI: 10.1371/journal.pbio.0030268
- August 11, 2009
- 09:42 PM
- 711 views
Whatever she wants - sexual selection
by Atila in Brazillion Thoughts
This post was translated by Igor Santos from the original published by Atila at the Brazilian blog Rainha Vermelha.==================================================================
Sexual selection is not the freshest of news. Darwin's grandfather Erasmus had already commented on it. [1]
But a very pertinent question is why it occurs, or at least, what is selected. After all, why does a female finds a male sexy?Two hypotheses could explain that. Fisher proposed the sexy gene hypothesis. He ........ Read more »
Ryan, M., Fox, J., Wilczynski, W., & Rand, A. (1990) Sexual selection for sensory exploitation in the frog Physalaemus pustulosus. Nature, 343(6253), 66-67. DOI: 10.1038/343066a0
Ryan, M. (1998) Sexual Selection, Receiver Biases, and the Evolution of Sex Differences. Science, 281(5385), 1999-2003. DOI: 10.1126/science.281.5385.1999
- September 6, 2010
- 06:28 AM
- 705 views
Novos genes? Ok. Uma organela? Pra já. Como um vírus pode trazer novas funções
by Atila in Rainha Vermelha
A lesma-do-mar Elysia chlorotica é famosa por sua associação com cloroplastos roubados da algas que come. Muitas lesmas deste gênero são capazes de preservar os cloroplastos das algas das quais se alimentam e mantê-los em células especializadas que contiuam recebendo luz solar e fazendo fotossíntese, agora para a nova hospedeira. Um processo chamado de cleptoplastia, ou roubo de organela.
A Elysia chlorotica é especial em relação ao roubo de cloroplastos por ser capaz de mantê-lo........ Read more »
Rohwer F, & Thurber RV. (2009) Viruses manipulate the marine environment. Nature, 459(7244), 207-12. PMID: 19444207
- August 12, 2009
- 12:31 AM
- 703 views
Abrindo caminho para nadar
by Atila in Rainha Vermelha
Helicobacter pylori. Fonte.Helicobacter pylori é aquela bactéria nada gentil que vive nos nossos
estômagos e dá uma ajudinha em uma úlcera ocasional. Além da capacidade
impressionante de sobreviver em um ambiente com pH 2, a bolsa de
esterilização que é o nosso estômago, ela ainda consegue se mover
através do muco estomacal, que é bem espesso. Se pensava que
os 4 a 6 flagelos dela - aqueles longos prolongamentos - fossem responsáveis
pela façanha, mas tem mais envolvido. Quando n........ Read more »
Jonathan P. Cellia, Bradley S. Turnerb, Nezam H. Afdhalb, Sarah Keatesb, Ionita Ghiranb, Ciaran P. Kellyb, Randy H. Ewoldtc, Gareth H. McKinleyc, Peter Sod, Shyamsunder Erramillia.... (2009) Helicobacter pylori moves through mucus by reducing mucin viscoelasticity . PNAS. info:/10.1073/pnas.0903438106
- July 28, 2009
- 10:40 PM
- 699 views
Honesto que mente ou desonesto que se controla?
by Atila in Rainha Vermelha
Uma questão bem pertinente sobre honestidade. Em uma situação onde você pode levar vantagem sendo desonesto, o que acontece, você tende a mentir mas se contém ou você tende a ser honesto e faz uma forcinha para mentir?
Segundo House et al., pessoas sempre mentem, mas qual é o ponto
de partida? Nosso cérebro precisa se controlar ativamente para mentir ou para não
mentir? Pesquisar esse tipo de resposta sempre é complicado, uma vez
que quando você vira para o voluntário e fala: "M........ Read more »
Greene, J., & Paxton, J. (2009) Patterns of neural activity associated with honest and dishonest moral decisions. Proceedings of the National Academy of Sciences, 106(30), 12506-12511. DOI: 10.1073/pnas.0900152106
- September 9, 2009
- 11:16 PM
- 678 views
Prior immunity and flu
by Atila Iamarino in Influenza A (H1N1) Blog – English
I received a comment from Paulo Amaral with amazing questions, leading me to advance this post. As follows, you can find the questions and the answer explaining what is relevant:
Would the annual vaccination against flu be liable for the low number of reports in elders?
What is the efficacy of the vaccine produced by mettles of [...]... Read more »
Smith, G., Bahl, J., Vijaykrishna, D., Zhang, J., Poon, L., Chen, H., Webster, R., Peiris, J., & Guan, Y. (2009) From the Cover: Dating the emergence of pandemic influenza viruses. Proceedings of the National Academy of Sciences, 106(28), 11709-11712. DOI: 10.1073/pnas.0904991106
Morens, D., Taubenberger, J., & Fauci, A. (2009) The Persistent Legacy of the 1918 Influenza Virus. New England Journal of Medicine, 361(3), 225-229. DOI: 10.1056/NEJMp0904819
Palese, P., Tumpey, T., & Garcia-Sastre, A. (2006) What Can We Learn from Reconstructing the Extinct 1918 Pandemic Influenza Virus?. Immunity, 24(2), 121-124. DOI: 10.1016/j.immuni.2006.01.007
Yu, X., Tsibane, T., McGraw, P., House, F., Keefer, C., Hicar, M., Tumpey, T., Pappas, C., Perrone, L., Martinez, O.... (2008) Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. Nature, 455(7212), 532-536. DOI: 10.1038/nature07231
Centers for Disease Control and Prevention (CDC). (2009) Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR. Morbidity and mortality weekly report, 58(19), 521-4. PMID: 19478718
- July 21, 2009
- 09:37 PM
- 668 views
Fazendo o gosto dela - Seleção sexual
by Atila in Rainha Vermelha
Este texto é complementar ao meu outro post no Papo de Homem*. Lá trato da evolução do cafajeste, como a seleção sexual pode deixar o mais forte de lado e favorecer homens que tenham filhos fora do relacionamento, e um exemplo de alguém muito bem sucedido nessa empreitada. Aqui trato de como a preferência de fêmeas na seleção sexual pode surgir.
*Assim que o texto sair lá, atualizo aqui com o linkA seleção sexual não é uma grande novidade, o próprio avô de Darwin, Erasmus, já........ Read more »
Ryan, M., Fox, J., Wilczynski, W., & Rand, A. (1990) Sexual selection for sensory exploitation in the frog Physalaemus pustulosus. Nature, 343(6253), 66-67. DOI: 10.1038/343066a0
Ryan, M. (1998) Sexual Selection, Receiver Biases, and the Evolution of Sex Differences. Science, 281(5385), 1999-2003. DOI: 10.1126/science.281.5385.1999
- September 14, 2009
- 05:10 PM
- 666 views
Recordando: Plantas carnívoras
by Atila in Rainha Vermelha
Pretendo fazer vários posts sobre plantas carnívoras, e para começar [update: fiquei só nesse mesmo] , veremos a Dionaea muscipula, chamada por Darwin de "uma das plantas mais maravilhosas do mundo" e também conhecida como Vênus Papa-moscas ou aquela planta da boquinha.
As carnívoras têm muito mais em comum com outras plantas do que se pode imaginar. Elas também realizam fotossíntese, captando CO2 do ar e sais minerais do solo. Então elas são carnívoras por quê? O solo onde ficam c........ Read more »
Forterre, Y., Skotheim, J., Dumais, J., & Mahadevan, L. (2005) How the Venus flytrap snaps. Nature, 433(7024), 421-425. DOI: 10.1038/nature03185
- August 27, 2009
- 09:44 PM
- 659 views
Why we fear Influenza 1 – the antivirals
by Atila Iamarino in Influenza A (H1N1) Blog – English
First of all, to start this blog, and discuss the H1N1 and the flu in general, I decided to start with texts considering the other side of the Influenza. Let’s see what is going on with the virus and the decisions taken towards the virus.
With viruses such as [...]... Read more »
De Clercq, E. (2002) STRATEGIES IN THE DESIGN OF ANTIVIRAL DRUGS. Nature Reviews Drug Discovery, 1(1), 13-25. DOI: 10.1038/nrd703
- September 20, 2009
- 07:25 PM
- 652 views
How do we name Influenza A?
by Atila Iamarino in Influenza A (H1N1) Blog – English
Where do the name H1N1 and all the other names come from? What determines the number of H and N?
Established by WHO in1980 [1], the nomenclature of Influenza A consists of: type of host, in case the virus has not been isolated from humans; geographical region of origin; number of lineage; year of isolation and; [...]... Read more »
no authors. (1980) A revision of the system of nomenclature for influenza viruses: a WHO memorandum. Bulletin of the World Health Organization, 58(4), 585-91. PMID: 6969132
Subbarao, K. (1998) Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness. Science, 279(5349), 393-396. DOI: 10.1126/science.279.5349.393
Fouchier, R., Munster, V., Wallensten, A., Bestebroer, T., Herfst, S., Smith, D., Rimmelzwaan, G., Olsen, B., & Osterhaus, A. (2005) Characterization of a Novel Influenza A Virus Hemagglutinin Subtype (H16) Obtained from Black-Headed Gulls. Journal of Virology, 79(5), 2814-2822. DOI: 10.1128/JVI.79.5.2814-2822.2005
Liu, S., Ji, K., Chen, J., Tai, D., Jiang, W., Hou, G., Chen, J., Li, J., & Huang, B. (2009) Panorama Phylogenetic Diversity and Distribution of Type A Influenza Virus. PLoS ONE, 4(3). DOI: 10.1371/journal.pone.0005022
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