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Biólogo e estudade de doutorado em Evolução do vírus HIV na USP. Community leader do ScienceBlogs Brasil e editor do Research Blogging em português.
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Influenza A (H1N1) Blog – Português
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Gripe por A (H1N1) Blog
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- June 22, 2010
- 12:20 AM
- 254 views
Cerdos son portadores del Influenza
by Atila Iamarino in Gripe por A (H1N1) Blog
¿Por qué los más viejos fueron los menos afectados por la nueva gripe?
©be_khe
Los ancianos, principalmente aquellos con más de 65 años, o sea, los nacidos antes de 1944, constituyen parte de la población menos afectada por la gripe h1n1. Fue sugerido y posteriormente confirmado por el CDC que se trata de inmunidad previa al virus. [...]... Read more »
Manicassamy, B., Medina, R., Hai, R., Tsibane, T., Stertz, S., Nistal-Villán, E., Palese, P., Basler, C., & García-Sastre, A. (2010) Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines. PLoS Pathogens, 6(1). DOI: 10.1371/journal.ppat.1000745
- June 22, 2010
- 12:20 AM
- 444 views
Pigs are reservoirs of Influenza
by Atila Iamarino in Influenza A (H1N1) Blog – English
Why were the older people less affected by the new flu?
©be_khe
The elderly, especially those older than 65 years, that is, born before 1944, constitute the part of the population less affected by H1N1. It was suggested and later confirmed by CDC that it is about the prior immunity to the virus. These people probably have [...]... Read more »
Manicassamy, B., Medina, R., Hai, R., Tsibane, T., Stertz, S., Nistal-Villán, E., Palese, P., Basler, C., & García-Sastre, A. (2010) Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines. PLoS Pathogens, 6(1). DOI: 10.1371/journal.ppat.1000745
- June 20, 2010
- 10:12 PM
- 252 views
Influenza A H1N1: o estado corrente
by Atila Iamarino in Influenza A (H1N1) Blog – Português
Passado mais de um ano desde os primeiros casos de Influenza A H1N1 no México, tivemos mais de 18000 mortes com diagnóstico confirmado em laboratório e reportado à OMS. Com certeza uma sub-estimativa do número total de casos.
Dos casos confirmados, a mortalidade média foi de 0,5%, próxima da gripe sazonal. Os valores de mortalidade variaram bastante de [...]... Read more »
Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza, Bautista E, Chotpitayasunondh T, Gao Z, Harper SA, Shaw M, Uyeki TM, Zaki SR, Hayden FG, Hui DS.... (2010) Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. The New England journal of medicine, 362(18), 1708-19. PMID: 20445182
- June 20, 2010
- 08:06 PM
- 313 views
Transmisión de la Influenza Aviaria limitada a la nariz fría
by Atila Iamarino in Gripe por A (H1N1) Blog
Una de las grandes dudas sobre el Influenza Aviaria es por que el no es transmitido de manera eficiente entre humanos. Así, queda claro cuan probable es que el virus pueda transponer esta barrera y surja una linaje más eficiente. El H5N1 por ejemplo hasta ahora fue transmitido principalmente para criadores y personas con contacto [...]... Read more »
Scull MA, Gillim-Ross L, Santos C, Roberts KL, Bordonali E, Subbarao K, Barclay WS, & Pickles RJ. (2009) Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways. PLoS pathogens, 5(5). PMID: 19436701
- June 20, 2010
- 08:06 PM
- 394 views
Transmission of Avian Influenza restricted by cold nose
by Atila Iamarino in Influenza A (H1N1) Blog – English
One of the greater uncertanties about Avian Influenza is why it is not efficiently transmitted among humans. Thus, it is clear how likely it is that the virus is able to cross this barrier and a more efficient line appears. For example, until now the H5N1 was transmitted mainly to breeders and people in very [...]... Read more »
Scull MA, Gillim-Ross L, Santos C, Roberts KL, Bordonali E, Subbarao K, Barclay WS, & Pickles RJ. (2009) Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways. PLoS pathogens, 5(5). PMID: 19436701
- June 18, 2010
- 05:30 AM
- 426 views
Vírus da gripe suína muda em porcos na China
by Atila in Rainha Vermelha
©be_khe
Aproveitando que há um certo tempo não reclamo de uma notícia, vou combinar minha interpretação de um artigo recém publicado na Science e uma crítica à reportagem do iG (em itálico as partes que quero destacar):
Chineses apresentam nova genética da gripe suína
Pesquisadores identificaram mutações em oito genes do H1N1 que podem, eventualmente, contaminar seres humanos
[...]
Durante o monitoramento de porcos em um matad........ Read more »
Vijaykrishna, D., Poon, L., Zhu, H., Ma, S., Li, O., Cheung, C., Smith, G., Peiris, J., & Guan, Y. (2010) Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine. Science, 328(5985), 1529-1529. DOI: 10.1126/science.1189132
- June 13, 2010
- 07:45 PM
- 572 views
A universal flu vaccine
by Atila Iamarino in Influenza A (H1N1) Blog – English
Will we have a universal Influenza vaccine someday? Will we find something that eliminates the need of developing a new vaccine every year and ensuring that great part of the population receives it?
The annual development of flu vaccines is a very expensive way of avoiding this disease even if it is the most efficient way. [...]... Read more »
Sui, J., Hwang, W., Perez, S., Wei, G., Aird, D., Chen, L., Santelli, E., Stec, B., Cadwell, G., Ali, M.... (2009) Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nature Structural , 16(3), 265-273. DOI: 10.1038/nsmb.1566
Wang, T., & Palese, P. (2009) Universal epitopes of influenza virus hemagglutinins?. Nature Structural , 16(3), 233-234. DOI: 10.1038/nsmb.1574
- June 13, 2010
- 07:42 PM
- 284 views
Una vacuna universal contra la gripe
by Atila Iamarino in Gripe por A (H1N1) Blog
¿Algún día tendremos una vacuna universal contra el Influenza? ¿Algo que acabe con la necesidad de todos los años tener que desarrollar una nueva vacuna y garantizar que una gran parte de la población la reciba?
Desarrollar vacunas anuales contra la gripe es una manera muy costosa de evitar esta enfermedad, por más que sea la [...]... Read more »
Sui, J., Hwang, W., Perez, S., Wei, G., Aird, D., Chen, L., Santelli, E., Stec, B., Cadwell, G., Ali, M.... (2009) Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nature Structural , 16(3), 265-273. DOI: 10.1038/nsmb.1566
Wang, T., & Palese, P. (2009) Universal epitopes of influenza virus hemagglutinins?. Nature Structural , 16(3), 233-234. DOI: 10.1038/nsmb.1574
- June 6, 2010
- 07:42 PM
- 418 views
H5N1, the bird flu: the virus
by Atila Iamarino in Influenza A (H1N1) Blog – English
In the last text, it was discussed the capacity of H5N1 of infecting a number of hosts and causing very harsh symptoms, causing deaths in over 50% of the recorded human cases. Despite this, its transmission from person to person seems to be well limited. Now we will see its characteristics that contribute to this.
As [...]... Read more »
van Riel, D. (2006) H5N1 Virus Attachment to Lower Respiratory Tract. Science, 312(5772), 399-399. DOI: 10.1126/science.1125548
Zambon, M. (2007) Lessons from the 1918 influenza. Nature Biotechnology, 25(4), 433-434. DOI: 10.1038/nbt0407-433
Steinhauer, D. (1999) Role of Hemagglutinin Cleavage for the Pathogenicity of Influenza Virus. Virology, 258(1), 1-20. DOI: 10.1006/viro.1999.9716
Stech, O., Veits, J., Weber, S., Deckers, D., Schroer, D., Vahlenkamp, T., Breithaupt, A., Teifke, J., Mettenleiter, T., & Stech, J. (2009) Acquisition of a Polybasic Hemagglutinin Cleavage Site by a Low-Pathogenic Avian Influenza Virus Is Not Sufficient for Immediate Transformation into a Highly Pathogenic Strain. Journal of Virology, 83(11), 5864-5868. DOI: 10.1128/JVI.02649-08
- June 6, 2010
- 07:39 PM
- 228 views
H5N1, la gripe aviaria: El virus
by Atila Iamarino in Gripe por A (H1N1) Blog
En el texto anterior, se discutió la capacidad del H5N1 de infectar una serie de hospederos y causar síntomas muy severos, causando muertes en más de de 50% de los casos humanos registrados. A pesar de eso, su transmisión de persona para persona parece ser muy limitada. Ahora veremos cuales características suyas contribuyen para ello.
Conforme [...]... Read more »
van Riel, D. (2006) H5N1 Virus Attachment to Lower Respiratory Tract. Science, 312(5772), 399-399. DOI: 10.1126/science.1125548
Zambon, M. (2007) Lessons from the 1918 influenza. Nature Biotechnology, 25(4), 433-434. DOI: 10.1038/nbt0407-433
Steinhauer, D. (1999) Role of Hemagglutinin Cleavage for the Pathogenicity of Influenza Virus. Virology, 258(1), 1-20. DOI: 10.1006/viro.1999.9716
Stech, O., Veits, J., Weber, S., Deckers, D., Schroer, D., Vahlenkamp, T., Breithaupt, A., Teifke, J., Mettenleiter, T., & Stech, J. (2009) Acquisition of a Polybasic Hemagglutinin Cleavage Site by a Low-Pathogenic Avian Influenza Virus Is Not Sufficient for Immediate Transformation into a Highly Pathogenic Strain. Journal of Virology, 83(11), 5864-5868. DOI: 10.1128/JVI.02649-08
- June 1, 2010
- 02:04 AM
- 206 views
Influenza pandémica: el papel de las aves de corral
by Atila Iamarino in Gripe por A (H1N1) Blog
Nunca en la historia humana hemos criado tantos puercos y gallinas como actualmente. La creciente demanda por carne, en especial en países en desarrollo como China, ejerce una gran presión por el aumento de la cantidad de carne en el comercio. Así, cada vez más aves silvestres son cazadas y cada vez más aves domésticas [...]... Read more »
Dugan, V., Chen, R., Spiro, D., Sengamalay, N., Zaborsky, J., Ghedin, E., Nolting, J., Swayne, D., Runstadler, J., Happ, G.... (2008) The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds. PLoS Pathogens, 4(5). DOI: 10.1371/journal.ppat.1000076
Guan, Y. (1999) Molecular characterization of H9N2 influenza viruses: Were they the donors of the "internal" genes of H5N1 viruses in Hong Kong?. Proceedings of the National Academy of Sciences, 96(16), 9363-9367. DOI: 10.1073/pnas.96.16.9363
- June 1, 2010
- 02:04 AM
- 353 views
Pandemic Influenza: the role of poultry birds
by Atila Iamarino in Influenza A (H1N1) Blog – English
Never in history of mankind have we reared as many pigs and chickens as now. The growing demand for meat, especially in developing countries like China, exerts a great pressure in the increase of the quantity of meat in commerce. Therefore, more wild birds are being caught and more domestic birds are being bred. The [...]... Read more »
Dugan, V., Chen, R., Spiro, D., Sengamalay, N., Zaborsky, J., Ghedin, E., Nolting, J., Swayne, D., Runstadler, J., Happ, G.... (2008) The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds. PLoS Pathogens, 4(5). DOI: 10.1371/journal.ppat.1000076
Guan, Y. (1999) Molecular characterization of H9N2 influenza viruses: Were they the donors of the "internal" genes of H5N1 viruses in Hong Kong?. Proceedings of the National Academy of Sciences, 96(16), 9363-9367. DOI: 10.1073/pnas.96.16.9363
- May 28, 2010
- 04:04 AM
- 410 views
Temos de fato um Designer acima da evolução
by Atila in Rainha Vermelha
©Thea.trical •
Sim, meus caros. Durante estes longos dias de debate sobre Design Inteligente peregrinei pelo vasto terreno do PubMed. E após várias horas sem comer, sofrendo de delírios, um arbusto em chamas falou comigo um artigo me trouxe a luz. Encontrei o grande Criador. Sinceramente, encontrei vários artigos que mostram o que o DI defende, um Designer.
Ele, que é capaz de causar um evento de macroevolução diferenciando espécies que posteriormente sofrem microevoluçã........ Read more »
Suttle, C. (2005) Viruses in the sea. Nature, 437(7057), 356-361. DOI: 10.1038/nature04160
Sharon, I., Alperovitch, A., Rohwer, F., Haynes, M., Glaser, F., Atamna-Ismaeel, N., Pinter, R., Partensky, F., Koonin, E., Wolf, Y.... (2009) Photosystem I gene cassettes are present in marine virus genomes. Nature, 461(7261), 258-262. DOI: 10.1038/nature08284
La Scola, B., Desnues, C., Pagnier, I., Robert, C., Barrassi, L., Fournous, G., Merchat, M., Suzan-Monti, M., Forterre, P., Koonin, E.... (2008) The virophage as a unique parasite of the giant mimivirus. Nature, 455(7209), 100-104. DOI: 10.1038/nature07218
- May 24, 2010
- 09:43 AM
- 262 views
Porcos são repositórios de Influenza
by Atila Iamarino in Influenza A (H1N1) Blog – Português
Por que pessoas mais velhas foram as menos atingidas pela nova gripe?
©be_khe
Idosos, principalmente aqueles com mais de 65 anos, ou seja, os nascidos antes de 1944, constituem a parcela da população menos afetada pelo h1n1. Foi sugerido e posteriormente confirmado pelo CDC que trata-se de imunidade prévia ao vírus. Provavelmente, estas pessoas já haviam [...]... Read more »
Manicassamy, B., Medina, R., Hai, R., Tsibane, T., Stertz, S., Nistal-Villán, E., Palese, P., Basler, C., & García-Sastre, A. (2010) Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines. PLoS Pathogens, 6(1). DOI: 10.1371/journal.ppat.1000745
- May 12, 2010
- 05:51 AM
- 403 views
Contaminated Vaccines
by Atila Iamarino in Influenza A (H1N1) Blog – English
Although H1N1 is circulating around us at least a little bit before 1918, we passed almost 20 years free of it. In 1957, a line of influenza virus received three genes of an avian virus, among them new HA and NA, and started to be called H2N2. With these new proteins, it did not meet [...]... Read more »
Zimmer, S., & Burke, D. (2009) Historical Perspective -- Emergence of Influenza A (H1N1) Viruses. New England Journal of Medicine, 361(3), 279-285. DOI: 10.1056/NEJMra0904322
Scholtissek, C., von Hoyningen, V., & Rott, R. (1978) Genetic relatedness between the new 1977 epidemic strains (H1N1) of influenza and human influenza strains isolated between 1947 and 1957 (H1N1). Virology, 89(2), 613-617. DOI: 10.1016/0042-6822(78)90203-9
Kendal, A., Noble, G., Skehel, J., & Dowdle, W. (1978) Antigenic similarity of influenza A(H1N1) viruses from epidemics in 1977–1978 to “Scandinavian” strains isolated in epidemics of 1950–1951. Virology, 89(2), 632-636. DOI: 10.1016/0042-6822(78)90207-6
- May 12, 2010
- 05:51 AM
- 248 views
Vacunas contaminadas
by Atila Iamarino in Gripe por A (H1N1) Blog
A pesar de que el H1N1 circula entre nosotros desde por lo menos un poco antes de 1918, estuvimos libre de él por casi 20 años. En 1957, una linaje de Influenza recibió tres genes de un virus aviario, entre ellos nuevas HA y NA, y pasó a ser llamado de H2N2. Con estas nuevas [...]... Read more »
Zimmer, S., & Burke, D. (2009) Historical Perspective -- Emergence of Influenza A (H1N1) Viruses. New England Journal of Medicine, 361(3), 279-285. DOI: 10.1056/NEJMra0904322
Scholtissek, C., von Hoyningen, V., & Rott, R. (1978) Genetic relatedness between the new 1977 epidemic strains (H1N1) of influenza and human influenza strains isolated between 1947 and 1957 (H1N1). Virology, 89(2), 613-617. DOI: 10.1016/0042-6822(78)90203-9
Kendal, A., Noble, G., Skehel, J., & Dowdle, W. (1978) Antigenic similarity of influenza A(H1N1) viruses from epidemics in 1977–1978 to “Scandinavian” strains isolated in epidemics of 1950–1951. Virology, 89(2), 632-636. DOI: 10.1016/0042-6822(78)90207-6
- May 6, 2010
- 10:47 PM
- 436 views
Yes, nós temos complexo irredutível
by Atila in Rainha Vermelha
Sou obrigado a reconhecer que a biologia possui sim muita complexidade irredutível. ©Sergei Golyshev O criacionismo sempre foi uma crença baseada nas falhas da biologia. Por muito tempo, um dos principais argumentos que utilizavam para justificar um criador era a ausência de formas intermediárias. Como os seres humanos não foram criados por um ser maior, se não encontramos os passos que podem ter conduzido o caminho? Mas, conforme fomos estudando o meio natu........ Read more »
Yan, K., Fang, G., Bhardwaj, N., Alexander, R., & Gerstein, M. (2010) Comparing genomes to computer operating systems in terms of the topology and evolution of their regulatory control networks. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0914771107
- April 17, 2010
- 12:17 AM
- 494 views
Vacina contra diarréia contaminada
by Atila in Rainha Vermelha
Vacinas são realmente puras, e se não são, quais os tipos de contaminantes? Circovírus suíno 1 em imagem de microscopia. Fonte. Existem dois tipos principais de vacina: a inativada, que é feita de pedaços do patógeno (vírus ou bactéria que queremos combater) que não são capazes de causar infecção, como a vacina da gripe (tanto sazonal quanto do último H1N1); e a atenuada, que é feita cultivando o patógeno em um outro animal e selecionando variantes que quase não causam sintoma........ Read more »
Victoria, J., Wang, C., Jones, M., Jaing, C., McLoughlin, K., Gardner, S., & Delwart, E. (2010) Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virus. Journal of Virology. DOI: 10.1128/JVI.02690-09
- February 28, 2010
- 07:06 PM
- 384 views
H5N1, the bird flu: the hosts
by Atila Iamarino in Influenza A (H1N1) Blog – English
In 1997, a lineage of H5N1 bird flu was transmitted to a child in Hong Kong who died of respiratory problems. This was the first of a number of recorded cases of transmission of this virus from poultry to humans.
Since then, the world follows the circulation of this virus with concern. Although we associate it [...]... Read more »
Beigel JH, Farrar J, Han AM, Hayden FG, Hyer R, de Jong MD, Lochindarat S, Nguyen TK, Nguyen TH, Tran TH.... (2005) Avian influenza A (H5N1) infection in humans. The New England journal of medicine, 353(13), 1374-85. PMID: 16192482
Chen, H. (2006) Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control. Proceedings of the National Academy of Sciences, 103(8), 2845-2850. DOI: 10.1073/pnas.0511120103
- February 28, 2010
- 07:06 PM
- 231 views
H5N1, la gripe aviaria: los hospederos
by Atila Iamarino in Gripe por A (H1N1) Blog
En 1997, una línea de Influenza H5N1 aviaria fue transmitida para un niño en Hong Kong que falleció con problemas respiratorios. Este fue el primer de sucesivos casos registrados de transmisión de este virus de aves de crianza para humanos.
Desde entonces, el mundo acompaña preocupado la circulación de este virus. Aunque asociemos a casos graves [...]... Read more »
Beigel JH, Farrar J, Han AM, Hayden FG, Hyer R, de Jong MD, Lochindarat S, Nguyen TK, Nguyen TH, Tran TH.... (2005) Avian influenza A (H5N1) infection in humans. The New England journal of medicine, 353(13), 1374-85. PMID: 16192482
Chen, H. (2006) Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control. Proceedings of the National Academy of Sciences, 103(8), 2845-2850. DOI: 10.1073/pnas.0511120103
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