MedicalResearch.com Interview with: Igho Onakpoya MD MSc Clarendon Scholar University of Oxford Centre for Evidence-Based Medicine Nuffield Department of Primary Care Health Sciences Oxford UK MedicalResearch: What is the background for this study? What are the main findings? Dr. Onakpoya: Several … Continue reading →
The post Evidence of Value of Orphan Drugs Inconsistent appeared first on MedicalResearch.com Medical Research Interviews and News.
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Igho Onakpoya MD MSc, & Clarendon Scholar. (2015) Evidence of Value of Orphan Drugs Inconsistent. medicalresearch.com. info:/
Research from Columbia University Medical Center (CUMC) has uncovered further evidence of a system in the brain that persistently maintains memories for long periods of time. And paradoxically, it works in the same way as mechanisms that cause mad cow disease, kuru, and other degenerative brain diseases.... Read more »
Fioriti, L., Myers, C., Huang, Y., Li, X., Stephan, J., Trifilieff, P., Colnaghi, L., Kosmidis, S., Drisaldi, B., Pavlopoulos, E.... (2015) The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3. Neuron, 86(6), 1433-1448. DOI: 10.1016/j.neuron.2015.05.021
Drisaldi, B., Colnaghi, L., Fioriti, L., Rao, N., Myers, C., Snyder, A., Metzger, D., Tarasoff, J., Konstantinov, E., Fraser, P.... (2015) SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3. Cell Reports, 11(11), 1694-1702. DOI: 10.1016/j.celrep.2015.04.061
Stephan, J., Fioriti, L., Lamba, N., Colnaghi, L., Karl, K., Derkatch, I., & Kandel, E. (2015) The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton. Cell Reports, 11(11), 1772-1785. DOI: 10.1016/j.celrep.2015.04.060
Fiumara, F., Rajasethupathy, P., Antonov, I., Kosmidis, S., Sossin, W., & Kandel, E. (2015) MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream Targets. Cell Reports, 11(12), 1866-1875. DOI: 10.1016/j.celrep.2015.05.034
Mudambi (2008) notes that “value-added is becoming increasingly concentrated at the upstream and downstream ends of the value chain” and that “activities at both ends of the value chain are intensive in their application of knowledge and creativity”. Value-added along the value chain is, thus, represented by a “smiling curve”. Mudambi, R. (2008). Location, Control […]... Read more »
Mudambi, R. (2008) Location, Control and Innovation in Knowledge-intensive Industries. Journal of Economic Geography, 8(5), 699-725. DOI: 10.1093/jeg/lbn024
I must thank Leah Hardy (@LeahFHardy) for bringing to my attention the paper by Qinglong Shang and colleagues  (open-access available here) reporting that: "Ad36 [Human adenovirus 36] infection is associated with an increased risk of obesity development."Based on a meta-analysis of the available research literature examining whether Ad-36 - "a nonenveloped icosahedral virus comprised of double-stranded DNA and is one of 56 serotypes in 7 subgroups of human adenoviruses" - might........ Read more »
Shang Q, Wang H, Song Y, Wei L, Lavebratt C, Zhang F, & Gu H. (2014) Serological data analyses show that adenovirus 36 infection is associated with obesity: a meta-analysis involving 5739 subjects. Obesity (Silver Spring, Md.), 22(3), 895-900. PMID: 23804409
Rapid eye movement or REM sleep actively converts waking experiences into lasting memories and abilities in young brains reports a new study. The finding broadens the understanding of children’s sleep needs and calls into question the increasing use of REM-disrupting medications such as stimulants and antidepressants.
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Michelle C. Dumoulin Bridi, Sara J. Aton, Julie Seibt, Leslie Renouard, Tammi Coleman1, & Marcos G. Frank. (2015) Rapid eye movement sleep promotes cortical plasticity in the developing brain. Science Advances. info:/10.1126/sciadv.1500105
The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. A group of researchers discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases.... Read more »
Nikolay A. Pestov, Nadezhda S. Gerasimova, Olga I. Kulaeva, & Vasily M. Studitsky. (2015) Structure of transcribed chromatin is a sensor of DNA damage. Science Advances. info:/10.1126/sciadv.1500021
When you smile at a party, your facial expression is emotionally consistent with the happy context and as a consequence other guests will in future be more likely to remember that they've seen your face before, and where you were when they saw you. That's according to a team of Italian researchers led by Stefania Righi who have explored how memory for a face is affected by the emotion shown on that face and the congruence between that emotional expression and its surrounding context.The research........ Read more »
Righi, S., Gronchi, G., Marzi, T., Rebai, M., & Viggiano, M. (2015) You are that smiling guy I met at the party! Socially positive signals foster memory for identities and contexts. Acta Psychologica, 1-7. DOI: 10.1016/j.actpsy.2015.05.001
MedicalResearch.com Interview with: Prof. Patrick L Kinney Ph.D. Professor of Environmental Health Sciences and Director, Columbia Climate and Health Program Mailman School of Public Health Columbia University, New York, NY Medical Research: What is the background for this study? Dr. Kinney: … Continue reading →
The post Warming Climate May Not Reduce Winter Mortality appeared first on MedicalResearch.com Medical Research Interviews and News.
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Prof. Patrick L Kinney Ph.D., & Professor of Environmental Health Sciences. (2015) Warming Climate May Not Reduce Winter Mortality. MedicalResearch.com. info:/
Can we learn without being aware of what we're learning? Many psychologists say that 'unconscious', or implicit, learning exists.
But in a new paper, London-based psychologists Vadillo, Konstantinidis, and Shanks call the evidence for this into question.
Vadillo et al. focus on one particular example of implicit learning, the contextual cueing paradigm. This involves a series of stimulus patterns, each consisting of a number of "L" shapes and one "T" shape in various orientations. For ... Read more »
Vadillo MA, Konstantinidis E, & Shanks DR. (2015) Underpowered samples, false negatives, and unconscious learning. Psychonomic bulletin . PMID: 26122896
MedicalResearch.com Interview with: Dr. F. Xavier Pi–Sunyer MD Division of Endocrinology and Obesity Research Center Columbia University, New York Medical Research: What is the background for this study? What are the main findings? Dr. Pi-Sunye: In a large randomized trial, … Continue reading →
The post Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients appeared first on MedicalResearch.com Medical Research Interviews and News.
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Dr. F. Xavier Pi-Sunyer MD, & Division of Endocrinology and Obesity Research Center. (2015) Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates George Washington University Medical Research: What is the background for this study? What are the main findings? Response: Many factors are associated with lower testosterone levels and … Continue reading →
The post Low Testosterone Linked To Obesity and Depression In Men appeared first on MedicalResearch.com Medical Research Interviews and News.
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Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates. (2015) Low Testosterone Linked To Obesity and Depression In Men. MedicalResearch.com. info:/
When you look at a kangaroo or a wallaby, it's obvious the animal is well built for bouncing around the outback. What may be less obvious is that its arms are built for fighting—if it's male, that is. Males of these species have disproportionately long arm bones. And the more brawling a species does, the more exaggerated the difference between the beefy-armed males and their normal-limbed mates.
To understand this evolutionary quirk, we'll need to review the rules of fighting in wallabie........ Read more »
Richards, H., Grueter, C., & Milne, N. (2015) Strong arm tactics: sexual dimorphism in macropodid limb proportions. Journal of Zoology. DOI: 10.1111/jzo.12264
Animal models can be useful for understanding disease pathology and as preclinical models for drug testing. As BHD patients develop renal cell carcinomas (RCCs) of varied histologies, associated with a loss of FLCN, BHD animal models could be used to study of a wide range of renal cancer subtypes. Current BHD mouse models include kidney-specific Flcn-knockouts (Chen et al., 2008, Baba et al., 2008) and ubiquitous knockouts (Hasumi et al., 2009, Hartman et al., 2009, Hudon et al., 2010). The form........ Read more »
Chen J, Huang D, Rubera I, Futami K, Wang P, Zickert P, Khoo SK, Dykema K, Zhao P, Petillo D.... (2015) Disruption of tubular Flcn expression as a mouse model for renal tumor induction. Kidney international. PMID: 26083655
Adding some ‘worry time’ to your day could work better than pills.... Read more »
Koffel EA, Koffel JB, & Gehrman PR. (2015) A meta-analysis of group cognitive behavioral therapy for insomnia. Sleep medicine reviews, 6-16. PMID: 24931811
Sivertsen B, Omvik S, Pallesen S, Bjorvatn B, Havik OE, Kvale G, Nielsen GH, & Nordhus IH. (2006) Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA, 295(24), 2851-8. PMID: 16804151
A new research article shows that the ventral striatum includes a representation of the value attributed to potential choices in a gambling task, and of the decision eventually reached.... Read more »
Strait, C., Sleezer, B., & Hayden, B. (2015) Signatures of Value Comparison in Ventral Striatum Neurons. PLOS Biology, 13(6). DOI: 10.1371/journal.pbio.1002173
I was really rather happy to see the "preliminary evidence" reported by Rebecca Schmidt and colleagues  when it came to examining whether selected vitamin D metabolic gene variants might show linkage to autism spectrum disorder (ASD) based on data derived from the CHARGE initiative.For quite a while now I've discussed the various peer-reviewed science on the topic of vitamin D deficiency / insufficiency with autism in mind on this blog (see here and see here for example). Specifically, h........ Read more »
Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, & Tassone F. (2015) Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early human development, 91(8), 483-489. PMID: 26073892
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Foot Strike Pattern and Injury Rates... Read more »
Warr BJ, Fellin RE, Sauer SG, Goss DL, Frykman PN, & Seay JF. (2015) Characterization of Foot-Strike Patterns: Lack of an Association With Injuries or Performance in Soldiers. Military medicine, 180(7), 830-4. PMID: 26126256
MedicalResearch.com Interview with: Dr. Bahman Guyuron MD Cleveland and Lyndhurst, Ohio From the Department of Plastic Surgery, University Hospital Case Medical Center; and the American Migraine Center Medical Research: What is the background for this study? Dr. Guyuron: Through several … Continue reading →
The post Study Compares Two Surgical Techniques To Relieve Migraine Headaches appeared first on MedicalResearch.com Medical Research Interviews and News.
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Dr. Bahman Guyuron MD, & Cleveland and Lyndhurst. (2015) Study Compares Two Surgical Techniques To Relieve Migraine Headaches. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Chao Cheng, Ph.D. Assistant Professor Department of Genetics Institute for Quantitative Biomedical Sciences Geisel School of Medicine at Dartmouth Hanover NH, 03755 Medical Research: What is the background for this study? Dr. Cheng: Bladder cancer is a … Continue reading →
The post Biomarker Predicts Bladder Cancer Response To Treatment appeared first on MedicalResearch.com Medical Research Interviews and News.
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Chao Cheng, Ph.D., & Assistant Professor. (2015) Biomarker Predicts Bladder Cancer Response To Treatment. MedicalResearch.com. info:/
Physicists at the University of Sussex have found a way of using everyday technology found in kitchen microwaves and mobile telephones to bring quantum physics closer to helping solve enormous scientific problems that the most powerful of today’s supercomputers cannot even begin to embark upon.... Read more »
Weidt, S., Randall, J., Webster, S., Standing, E., Rodriguez, A., Webb, A., Lekitsch, B., & Hensinger, W. (2015) Ground-State Cooling of a Trapped Ion Using Long-Wavelength Radiation. Physical Review Letters, 115(1). DOI: 10.1103/PhysRevLett.115.013002
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