7 posts · 3,336 views
I want to discuss oversights and errors that I see in life sciences papers that somehow escape peer review. Hopefully, in a climate where there is a such surge of journals and the more established journals and publishers are getting harder to access, either at the time of submission of a manuscript or at the time of pointing out holes in the peer review process, an online critique of these papers can serve to point out the flaws in the system AND to accomplish what the original peer review could not.
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- May 31, 2012
- 12:05 PM
- 231 views
Alcoholic extracts of Aloe vera for diabetic rats
by SS in Scientific scrutiny
This 2008 paper describes the antidiabetic activity of an Aloe vera gel extract with histological data to show the changes in STZ-induced diabetic rats. This critique of the paper highlights the use of important data like extract doses (2004 J.Med. Food paper by Rajasekaran et al.), expected results, key hypotheses from earlier papers and the omission of important details such as the preparation of the different extracts of which the test extract was chosen as the best one. I couldn'........ Read more »
Noor Ayesha , Gunasekaran S, Manickam A. Soosai, & Vijayalakshmi M. A. . (2008) Antidiabetic activity of Aloe vera and histology of organs in streptozotocin-induced diabetic rats. Current Science, 94(8), 1078. DOI: http://cs-test.ias.ac.in/cs/Downloads/article_42590.pdf
- May 20, 2012
- 11:01 AM
- 524 views
Solution to ScFv to refolding
by SS in Scientific scrutiny
A comparison of two papers describing the separation of anti-TNF alpha ScFv from the soluble and insoluble fractions of the same bacterial supernatant.... Read more »
Sushma Krishnan, Vijayalakshmi Mookambeswaran A., Krishnan Venkataraman, & Satheeshkumar Padikara Kutty. (2011) Cloning, expression, purification and characterization of a single chain variable fragment specific to tumor necrosis factor alpha in Escherichia coli. Journal of Biotechnology, 156(4), 244. DOI: 10.1016/j.jbiotec.2011.06.039
Sushma Krishnan, Bilgimol Chuvappumkal Joseph, Vijayalakshmi Mookambeswaran A., & Satheeshkumar Padikara Kutty. (2012) Recovery of active anti TNF-α ScFv through matrix-assisted refolding of bacterial inclusion bodies using CIM monolithic support. Journal of Chromatography B, 93. DOI: 10.1016/j.jchromb.2012.02.011
- May 19, 2012
- 06:19 AM
- 599 views
Metal affects (enzyme) activity
by SS in Scientific scrutiny
A discussion of why attention should be paid to the choice of metal ions in metal ion chromatography.... Read more »
Kandukuri Sai Srikar, Noor Ayesha, Ranjini S. Shiva, & Vijayalakshmi M.A. (2012) Purification and characterization of catalase from sprouted black gram (Vigna mungo) seeds. Journal of Chromatography B, 54. DOI: 10.1016/j.jchromb.2012.01.029
Ajila, C., & Prasada Rao, U. (2009) Purification and characterization of black gram (Vigna mungo) husk peroxidase. Journal of Molecular Catalysis B: Enzymatic, 60(1-2), 36-44. DOI: 10.1016/j.molcatb.2009.03.014
- May 17, 2012
- 09:42 AM
- 466 views
The acid test for antibody function?
by SS in Scientific scrutiny
A discussion of various chromatographic conditions versus their purification outcomes, and a focus on acidic conditions for antibody purification. ... Read more »
Dhivya, A., Kumar, B., Prasanna, R., Jayaprakash, N., & Vijayalakshmi, M. (2010) Purification of Monoclonal Antibodies from Cell-Culture Supernatant by Use of Anion-Exchange Convective Interaction Media (CIM) Monolithic Columns. Chromatographia, 72(11-12), 1183-1188. DOI: 10.1365/s10337-010-1787-3
- May 17, 2012
- 08:48 AM
- 529 views
Autoimmune hydrolytic antibodies
by SS in Scientific scrutiny
A discussion of the chromatographic procedures done to purify antibodies from sera of rheumatoid arthritis patients and the study design described. ... Read more »
Kamalanathan AS, Goulvestre C, Weill B, & Vijayalakshmi MA. (2010) Proteolysis activity of IgM antibodies from rheumatoid arthritis patients' sera: evidence of atypical catalytic site. Journal of molecular recognition : JMR, 23(6), 577-82. PMID: 21031477
Kamalanathan A. S., & Vijayalakshmi M. A. (2009) Molecular studies of rheumatoid factor using pseudobioaffinity membrane chromatography. Journal of Molecular Recognition, 22(2), 153. DOI: 10.1002/jmr.921
- May 16, 2012
- 08:40 AM
- 446 views
Mixed opinions, disturbed flow
by SS in Scientific scrutiny
Analysis of the flaws in study design for the comparison of different sorbents in their interactions with antibodies. ... Read more »
Ranjini S. Shiva, Bimal Devla, Dhivya A.P., & Vijayalakshmi M.A. (2010) Study of the mechanism of interaction of antibody (IgG) on two mixed mode sorbents. Journal of Chromatography B, 878(15-16), 1037. DOI: 10.1016/j.jchromb.2010.03.005
- May 10, 2012
- 11:34 PM
- 541 views
Seeing the error in science
by SS in Scientific scrutiny
A look at how busy/careless the journal publishers/editors/reviewers can get when they cannot check figures, errors bars etc. ... Read more »
B. Chandrasekhar Reddy,, Ayesha Noor,, N.C. Sarada,, & M.A. Vijayalakshmi. (2011) Antioxidant properties of Cordyline terminalis (L.) Kunth and Myristica fragrans Houtt. encapsulated separately into casein beads. Current Science , 101(3), 416-420. info:/
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