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Brain Posts
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- June 17, 2013
- 12:03 PM
- 67 views
Brain Insula Signals Response to Depression Treatment
by William Yates, M.D. in Brain Posts
In a previous post, I reviewed a research summary of the potential for brain imaging to be a clinical tool in the diagnosis of brain disorders in the mood disorders domain.One of the key points in that review is the value of finding brain biomarkers for response to specific treatments.To follow up on this point, a recent research study has been published that proposes the brain insular cortex region may be key to determining specific treatment response in major depressive disorder.Helen Mayberg ........ Read more »
McGrath CL, Kelley ME, Holtzheimer PE, Dunlop BW, Craighead WE, Franco AR, Craddock RC, & Mayberg HS. (2013) Toward a Neuroimaging Treatment Selection Biomarker for Major Depressive Disorder. JAMA psychiatry (Chicago, Ill.), 1-9. PMID: 23760393
- June 12, 2013
- 11:25 AM
- 82 views
Brain Imaging for Diagnosis of Mood Disorders
by William Yates, M.D. in Brain Posts
Brain imaging holds promise for improving the accuracy of diagnosis in brain disorders falling under the psychiatric domain.No reliable and valid brain imaging techniques currently exist for the diagnosis of depression or bipolar disorder. However, research progress has been rapid.Jonathan Savitz from the Laureate Institute for Brain Research and colleagues at Harvard University and Johnson and Johnson Research and Development recently summarized the current state of knowledge in........ Read more »
Savitz JB, Rauch SL, & Drevets WC. (2013) Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play. Molecular psychiatry, 18(5), 528-39. PMID: 23546169
- June 11, 2013
- 10:54 AM
- 31 views
Sleep Effects of Orexin Receptor Drugs in Insomnia
by William Yates, M.D. in Brain Posts
In a previous post, I reviewed a recently clinical trial studying the effect of an orexin receptor blocking agent in the treatment of insomnia.Orexin appears to be a neurochemical involved in arousability and motor activity. Preliminary studies suggest the orexin receptor may provide a novel target for hypnotics in the treatment of insomnia.An important question in the effects of orexin is whether the hypnotic effect of orexin simulates the same sleep effects as seen by the more studied be........ Read more »
Bettica, P., Squassante, L., Groeger, J., Gennery, B., Winsky-Sommerer, R., & Dijk, D. (2012) Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia. Neuropsychopharmacology, 37(5), 1224-1233. DOI: 10.1038/npp.2011.310
- June 6, 2013
- 10:06 AM
- 41 views
Orexin Antagonist Drugs for Insomnia Treatment
by William Yates, M.D. in Brain Posts
Current drug treatment approaches for insomnia have significant limitations. Benzodiazepine receptor drugs have clinical effectiveness but may contribute to morning sedation and cognitive impairment.One promising drug development target is the orexin receptor. The effect of orexin-A on arousal and sleep has been extensively studied in rat models. Injection of orexin-A into the brain in rats results in increased firing of the locus coeruleus, increased physical activity, reduced........ Read more »
Bettica P, Squassante L, Zamuner S, Nucci G, Danker-Hopfe H, & Ratti E. (2012) The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia. Sleep, 35(8), 1097-104. PMID: 22851805
- June 4, 2013
- 11:01 AM
- 207 views
Melatonin for Insomnia: Research Summary
by William Yates, M.D. in Brain Posts
Molecular Model of MelatoninInsomnia is a common problem in the general population and is linked to greater health care utilization and increased mortality risk.Primary sleep disorder including primary insomnia are conditions that are not explained by a medical, substance use or mental disorder. Treatment options for primary sleep disorders include psychological interventions and medications. Melatonin is a commonly used drug that is available over the counter in the United States.Th........ Read more »
Ferracioli-Oda E, Qawasmi A, & Bloch MH. (2013) Meta-analysis: melatonin for the treatment of primary sleep disorders. PloS one, 8(5). PMID: 23691095
- June 3, 2013
- 11:09 AM
- 41 views
Can Brain Imaging Aid in the Diagnosis of ADHD?
by William Yates, M.D. in Brain Posts
Brain Cerebellum Highlighted in PurpleBrain imaging advances to date are predominantly within the domain of research with limited clinical utility.However, brain imaging techniques such as sensitive structural imaging methods, functional connectivity imaging, combined EEG and structural brain imaging and diffusion tensor imaging hold promise for clinical applications.An obvious application would be the use of brain imaging in confirmation of the diagnosis of brain disorders. Such methods w........ Read more »
Lim L, Marquand A, Cubillo AA, Smith AB, Chantiluke K, Simmons A, Mehta M, & Rubia K. (2013) Disorder-specific predictive classification of adolescents with attention deficit hyperactivity disorder (ADHD) relative to autism using structural magnetic resonance imaging. PloS one, 8(5). PMID: 23696841
- May 30, 2013
- 11:30 AM
- 198 views
Serotonin 2 Receptor May Be A Key Cocaine Addiction Target
by William Yates, M.D. in Brain Posts
3-Dimensional Model of Cocaine MoleculeCocaine dependence remains a significant public health problem in the U.S. and throughout the world. Relapse rates in cocaine dependence are high despite aggressive psychological interventions. No evidence-based pharmacological treatments are currently available as adjunctive measures in cocaine dependence.However, drug development in the treatment of cocaine dependence is an active area of research. Although cocaine and other stimulants a........ Read more »
Cunningham KA, Anastasio NC, Fox RG, Stutz SJ, Bubar MJ, Swinford SE, Watson CS, Gilbertson SR, Rice KC, Rosenzweig-Lipson S.... (2013) Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. ACS chemical neuroscience, 4(1), 110-21. PMID: 23336050
- May 29, 2013
- 09:49 AM
- 38 views
Epidemiology of Childhood Brain Disorders: Conduct Disorder
by William Yates, M.D. in Brain Posts
The U.S. Centers for Disease Control recently published an excellent review of the epidemiology of childhood brain disorders.In a previous post, I reviewed the findings in ADHD and in autism/autism spectrum disorder. In this post, I will summarize some of the key findings of the review for conduct disorder and oppositional defiant disorder.Conduct disorder and oppositional defiant disorder share some characteristics and can be conceptualized as two disorders along a line of severity. ........ Read more »
Perou R, Bitsko RH, Blumberg SJ, Pastor P, Ghandour RM, Gfroerer JC, Hedden SL, Crosby AE, Visser SN, Schieve LA.... (2013) Mental health surveillance among children - United States, 2005-2011. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002), 62(2), 1-35. PMID: 23677130
- May 20, 2013
- 11:55 AM
- 82 views
Epidemiology of Childhood Brain Disorders: ADHD and Autism
by William Yates, M.D. in Brain Posts
The U.S. Centers for Disease Control has published a comprehensive summary of the epidemiology of childhood brain disorders in the most recent Morbidity and Mortality Weekly Report.This report produced some sensationalized headlines that up to 20% of children suffer from a mental disorder. However, I was more interested in looking at the prevalence estimates for some of the individual disorders from the report.The report collates data collected from a variety of surveys and data sets inclu........ Read more »
Perou R, Bitsko RH, Blumberg SJ, Pastor P, Ghandour RM, Gfroerer JC, Hedden SL, Crosby AE, Visser SN, Schieve LA.... (2013) Mental health surveillance among children - United States, 2005-2011. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002), 62(2), 1-35. PMID: 23677130
- May 10, 2013
- 10:33 AM
- 101 views
Insula Activation as a Biomarker for Depression Risk
by William Yates, M.D. in Brain Posts
Right and Left Insula Cortex Highlighted in TealBiomarker research in brain disorders including schizophrenia and mood disorders is an important pathway to early identification and prevention.In a previous post, I reviewed a summary of current biomarker research in schizophrenia. This summary suggested that accelerated brain gray matter volume decline during childhood and adolescence is a candidate biomarker in schizophrenia.In this post, I will look at a similar imaging biomarker study in........ Read more »
Whalley HC, Sussmann JE, Romaniuk L, Stewart T, Papmeyer M, Sprooten E, Hackett S, Hall J, Lawrie SM, & McIntosh AM. (2013) Prediction of depression in individuals at high familial risk of mood disorders using functional magnetic resonance imaging. PloS one, 8(3). PMID: 23483904
- May 9, 2013
- 11:24 AM
- 75 views
Biomarkers for Psychosis and Schizophrenia Risk
by William Yates, M.D. in Brain Posts
Prefrontal Cortex Highlighted in RedIdentifying valid biomarkers for psychosis and schizophrenia is an active focus in brain research.Tyronne Cannon, Ph.D. from Yale University recently presented a summary of research on this topic at the William K. Warren Neuroscience Symposium in Tulsa, Oklahoma. Here are my notes from his presentation along with related free full-text research references.Biomarker research in psychosis is important because current treatment for psychosis with the antipsy........ Read more »
Sun D, van Erp TG, Thompson PM, Bearden CE, Daley M, Kushan L, Hardt ME, Nuechterlein KH, Toga AW, & Cannon TD. (2009) Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms. Biological psychiatry, 66(11), 1055-60. PMID: 19729150
Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF.... (2010) Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. Archives of general psychiatry, 67(6), 578-88. PMID: 20530007
Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T.... (2012) Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study. Schizophrenia research, 134(1), 1-9. PMID: 22056201
- May 2, 2013
- 10:38 AM
- 145 views
Redefining Mental Disorders as Brain Disorders: TED Talk of Thomas Insel
by William Yates, M.D. in Brain Posts
Components of Brain Limbic SystemAdvances in the diagnosis and treatment of brain disorders like bipolar disorder, schizophrenia and autism are a public health priority.Dr. Thomas Insel, director at NIMH recently presented a TED talk that emphasized the need to rethink how we conceptualize and study these types of disorders. He argues for a need to redefine mental disorders as brain disorders. Advances in brain research tools are likely to provide improvements in early diagnosis and ........ Read more »
Collins, P., Insel, T., Chockalingam, A., Daar, A., & Maddox, Y. (2013) Grand Challenges in Global Mental Health: Integration in Research, Policy, and Practice. PLoS Medicine, 10(4). DOI: 10.1371/journal.pmed.1001434
Insel, T. (2011) A bridge to somewhere. Translational Psychiatry, 1(4). DOI: 10.1038/tp.2011.4
- May 1, 2013
- 11:54 AM
- 90 views
Advances In Parkinson's Disease Treatment: Part II
by William Yates, M.D. in Brain Posts
Globus Pallidus Region of Brain Targeted in DBS in YellowIn a previous post, I summarized some of the highlights of a recent review of Parkinson's disease management by the German neurologists Pedrosa and Timmerman.The first post can be located here and was limited to the drug treatment of the motor symptoms of Parkinson's disease.In part II, I want to focus on deep brain stimulation and the treatment of non-motor symptoms.The authors of the review note the following key points regarding deep br........ Read more »
Pedrosa, D., & Timmermann, . (2013) Review: management of Parkinson's disease. Neuropsychiatric Disease and Treatment, 321. DOI: 10.2147/NDT.S32302
- April 30, 2013
- 11:31 AM
- 170 views
Treatment Advances in Parkinson's Disease: Part I
by William Yates, M.D. in Brain Posts
3D Molecular Model of L-DopaDrug treatment of Parkinson's disease is a complex clinical problem. This complexity relates to several factors including incomplete response, multiple symptom domains and adverse effects of commonly used drugs.David Pedrosa and Lars Timmerman from the Department of Neurology at University Hospital Cologne in Germany have recently published an excellent review of Parkinson's disease management.The review is packed with comprehensive tables with specific drug inf........ Read more »
Pedrosa, D., & Timmermann, . (2013) Review: management of Parkinson's disease. Neuropsychiatric Disease and Treatment, 321. DOI: 10.2147/NDT.S32302
- April 29, 2013
- 10:37 AM
- 94 views
Essential Tremor as a Risk Factor for Parkinson's Disease
by William Yates, M.D. in Brain Posts
The number people suffereing from Parkison's disease in the United States is estimated to be between 500,000 and 1,000,000.The key symptoms of Parkinson's disease include tremor and slowed movement or bradykinesia.Known risk factors for Parkinson's disease include advanced age, male gender, family history of Parkinson's disease and exposure to pesticides.Of note, smokers appear to have a reduced risk of Parkinson's disease although the mechanism for this protective effect is unknown.Romero and c........ Read more »
Romero JP, Benito-León J, & Bermejo-Pareja F. (2012) The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor. Tremor and other hyperkinetic movements (New York, N.Y.). PMID: 23439396
- April 26, 2013
- 10:51 AM
- 253 views
MRI Biomarker for Parkinson's Disease Progression
by William Yates, M.D. in Brain Posts
Brain Putamen Highlighted in OrangeThe search for biomarkers for Alzheimer's disease is very active. I have summarized some of the relevant Alzheimer's biomarker research here and here.Biomarker research in Parkinson's disease has been less active.However, a recent research study published in Plos One demonstrated the potential for brain magnetic resonance imaging in Parkinson's disease.Miguel Ulla and colleagues in France conducted a prospective MRI study of 27 subjects with Parkinson's d........ Read more »
Ulla M, Bonny JM, Ouchchane L, Rieu I, Claise B, & Durif F. (2013) Is R2* a new MRI biomarker for the progression of Parkinson's disease? A longitudinal follow-up. PloS one, 8(3). PMID: 23469252
- April 25, 2013
- 11:15 AM
- 121 views
White Matter Changes in Schizophrenia
by William Yates, M.D. in Brain Posts
Schizophrenia is a disabling brain disorder characterized by psychotic symptoms such as hallucinations and delusions.Schizophrenia has a prevalence rate of about 1% of the population with relatively stable rates across nations and cultures.Early brain imaging studies focused on regional evidence of brain atrophy primarily in brain gray matter. However, with the development of diffusion tensor imaging, there is a growing body of research examining white matter changes in schizophrenia. &nbs........ Read more »
Alba-Ferrara, L., & de Erausquin, G. (2013) What does anisotropy measure? Insights from increased and decreased anisotropy in selective fiber tracts in schizophrenia. Frontiers in Integrative Neuroscience. DOI: 10.3389/fnint.2013.00009
- April 24, 2013
- 11:12 AM
- 124 views
DTI Identifies Brain Aging Changes
by William Yates, M.D. in Brain Posts
Brain white matter plays a key role in connecting functional brain areas. These connections are required for complex brain processing required for memory and executive functions, i.e planning and problem solving.Diffusion tensor imaging (DTI) is a relatively recent brain imaging tool that provides a method of analyzing regional human white matter function. Additionally, when DTI is paired with cognitive testing it allows for study of the brain regions and circuits responsible for spe........ Read more »
Sasson E, Doniger GM, Pasternak O, Tarrasch R, & Assaf Y. (2013) White matter correlates of cognitive domains in normal aging with diffusion tensor imaging. Frontiers in neuroscience, 32. PMID: 23493587
- April 23, 2013
- 11:15 AM
- 133 views
Hypothalaumus Connectivity Changes in Cluster Headaches
by William Yates, M.D. in Brain Posts
Cluster headaches are a relatively rare but serious pain disorder. Unlike the female-predominant migraine headache, cluster headaches occur predominantly in men. These headaches tend to be acute in onset and affect only one side of the head.The term cluster describes the typical chronological pattern of these headaches. The tend to occur regularly for days or weeks and are then separated by periods of remission lasting months or years.Attacks typically last between 15 minutes a........ Read more »
Qiu E, Wang Y, Ma L, Tian L, Liu R, Dong Z, Xu X, Zou Z, & Yu S. (2013) Abnormal brain functional connectivity of the hypothalamus in cluster headaches. PloS one, 8(2). PMID: 23460913
- April 22, 2013
- 12:12 PM
- 113 views
Exercise Boosts Brain Prefrontal Cortex in Children
by William Yates, M.D. in Brain Posts
Regular aerobic exercise has been associated with enhanced cognition in both children and adults. Most of these types of studies have been cross-sectional in design. Cross-sectional studies do a good job of examining association but do not prove causality. Prospective randomized control trials are better at examining the cause-effect relationship.So an important research question in the exercise-cognition domain is: Can an exercise intervention improve cognition in a prospectiv........ Read more »
Chaddock-Heyman, L., Erickson, K., Voss, M., Knecht, A., Pontifex, M., Castelli, D., Hillman, C., & Kramer, A. (2013) The effects of physical activity on functional MRI activation associated with cognitive control in children: a randomized controlled intervention. Frontiers in Human Neuroscience. DOI: 10.3389/fnhum.2013.00072
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