The pharmaceutical industry is in trouble at the moment, with many companies pulling out of development in certain areas and psychiatry is high on the list.The tale of one troubled would-be antidepressant has just been published in the form of a clinical trial that was terminated early when the parent company went under. But another company came along to save the day, so the drug might live on.Amitifadine is a triple reuptake inhibitor (TRI). What's that? Prozac and other SSRI antidepressants wo........ Read more »
Tran P, Skolnick P, Czobor P, Huang NY, Bradshaw M, McKinney A, & Fava M. (2011) Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. Journal of psychiatric research. PMID: 21925682
The present economic crisis has led to more suicides in Europe - but fewer deaths in road traffic accidents. So says a brief report in The Lancet. The authors show that suicide rates in people under the age of 65, which have been falling for several years in Europe, rose in 2008 and again in 2009, in line with unemployment figures. The overall effect was fairly small - 2009 was no worse than 2006. It still corresponds to a 5% annual increase in most countries. In Greece, Ireland, and Latvia the ........ Read more »
Stuckler D, Basu S, Suhrcke M, Coutts A, & McKee M. (2011) Effects of the 2008 recession on health: a first look at European data. Lancet, 378(9786), 124-5. PMID: 21742166
Here at Neuroskeptic we see a lot of dizzyingly bad (and sometimes even good) neuroscience, but did you know that brain scanners can literally send your head into a spin? A new paper explains why, with implications for all MRI researchers.MRI scanners rely on extremely powerful magnetic fields. This is why you can't take metal objects into the scanner room, as they'd be pulled into it. Yet the fields can also exert other kinds of effects on the body.I'd always been told that static, unchanging m........ Read more »
Roberts, D., Marcelli, V., Gillen, J., Carey, J., Della Santina, C., & Zee, D. (2011) MRI Magnetic Field Stimulates Rotational Sensors of the Brain. Current Biology. DOI: 10.1016/j.cub.2011.08.029
A major international study threatens to overturn what we thought we knew about schizophrenia. People with schizophrenia are more likely to get better if they live in poor countries: that's been known for about 25 years. In the 1980s, a series of pioneering World Health Organization (WHO) studies looked at the prognosis for people diagnosed with schizophrenia around the world.All of the data showed that people in developed countries were less likely to recover than those from poorer areas.T........ Read more »
Haro JM, Novick D, Bertsch J, Karagianis J, Dossenbach M, & Jones PB. (2011) Cross-national clinical and functional remission rates: Worldwide Schizophrenia Outpatient Health Outcomes (W-SOHO) study. The British journal of psychiatry : the journal of mental science, 194-201. PMID: 21881098
Seen Contagion yet?It's pretty scary. A new epidemic disease comes out of nowhere and starts killing everyone. It infects the brain - victims suffer seizures, or fall into a coma, and die. It spreads like wildfire. Humanity's only hope lies in Lawrence Fishburne and Kate Winslet.Luckily, that's fiction. But only just.In the movie, the killer bug is called "MEV-1", but it might as well have been called the Nipah virus, because it was closely based on a real disease of the same name. So much so th........ Read more »
Lo, M., & Rota, P. (2008) The emergence of Nipah virus, a highly pathogenic paramyxovirus. Journal of Clinical Virology, 43(4), 396-400. DOI: 10.1016/j.jcv.2008.08.007
One pill makes you largerAnd one pill makes you smallAnd the ones that mother gives youDon't do anything at allGo ask AliceWhen she's ten feet tallSo sang Jefferson Airplane in their psychedelic classic White Rabbit. While this song seems sure to have been inspired by the use of certain unapproved medications, don't have to be dropping acid to feel ten feet tall.A new paper from Germany reports on a case of "Alice In Wonderland Syndrome" associated with topiramate, an anti-epileptic drug also us........ Read more »
Jürgens TP, Ihle K, Stork JH, & May A. (2011) "Alice in Wonderland syndrome" associated with topiramate for migraine prevention. Journal of neurology, neurosurgery, and psychiatry, 82(2), 228-9. PMID: 20571045
Antidepressant sales have been rising for many years in Western countries, as regular Neuroskeptic readers will remember.Most of the studies on antidepressant use come from the USA and the UK, although the pattern also seems to hold for other European countries. The rapid rise of antidepressants from niche drugs to mega-sellers is perhaps the single biggest change in the way medicine treats mental illness since the invention of psychiatric drugs.But while a rise in sales has been observed ........ Read more »
Lockhart, P. and Guthrie, B. (2011) Trends in primary care antidepressant prescribing 1995–2007. British Journal of General Practice. info:/
According to a new paper, a full half of neuroscience papers that try to do a (very simple) statistical comparison are getting it wrong: Erroneous analyses of interactions in neuroscience: a problem of significance.Here's the problem. Suppose you want to know whether a certain 'treatment' has an affect on a certain variable. The treatment could be a drug, an environmental change, a genetic variant, whatever. The target population could be animals, humans, brain cells, or anything else.So you giv........ Read more »
Nieuwenhuis S, Forstmann BU, & Wagenmakers EJ. (2011) Erroneous analyses of interactions in neuroscience: a problem of significance. Nature neuroscience, 14(9), 1105-7. PMID: 21878926
Do men and women differ in their cognitive capacities? It's been a popular topic of conversation since as far back as we have records of what people were talking about.While it's now (almost) generally accepted that men and women are at most only very slightly different in average IQ, there are still a couple of lines of evidence in favor of a gender difference.First, there's the idea that men are more variable in their intelligence, so there are more very smart men, and also more very stupid on........ Read more »
Hoffman M, Gneezy U, & List JA. (2011) Nurture affects gender differences in spatial abilities. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21876159
After a period of heavy use, hard disks tend to get 'fragmented'. Data gets written all over random parts of the disk, and it gets inefficient to keep track of it all.
That's why you need to run a defragmentation program occasionally. Ideally, you do this overnight, while you're asleep, so it doesn't stop you from using the computer.
A new paper from some Stanford neuroscientists argues that the function of sleep is to reorganize neural connections - a bit like a disk defrag for the brain - a........ Read more »
Wang G, Grone B, Colas D, Appelbaum L, & Mourrain P. (2011) Synaptic plasticity in sleep: learning, homeostasis and disease. Trends in neurosciences. PMID: 21840068
Drugs that could modify or erase memories could soon be possible. We shouldn't rush to judge them unethical, says a Nature opinion piece by Adam Kolber, of the Neuroethics & Law Blog.
The idea of a pill that could make you forget something, or that could modify the emotional charge of a past experience, does seem rather disturbing.
Yet experiments on animals have gone a long to revealing the molecular mechanisms behind the formation and maintanence of memory traces. Much of the early work ........ Read more »
Boiron, a multinational pharmaceutical company, have threatened an Italian blogger with legal action, the BMJ reports.
Many people are concerned when big pharmaceutical companies do this kind of thing. So I don't think we should make any exception merely because Boiron's pharmaceuticals happen to be homeopathic ones.
Samuel Riva, who blogs (in Italian) at blogzero.it, put up some articles critical of homeopathy
which included pictures of Boiron’s blockbuster homoeopathic product Oscillococci........ Read more »
Turone F. (2011) Homoeopathy multinational Boiron threatens amateur Italian blogger. BMJ (Clinical research ed.). PMID: 21840920
PLoS ONE offers the confessions of a former medical ghostwriter: Being the Ghost in the Machine.
The article (which is open access and short, so well worth a read) explains how Linda Logdberg became a medical writer; what excited her about the job; what she actually did; and what made her eventually give it up.
Ghostwriting of course has a bad press at the moment and it's recently been banned by some leading research centres. Ghostwriting certainly is concerning, because of what it implies ab........ Read more »
Logdberg, L. (2011) Being the Ghost in the Machine: A Medical Ghostwriter's Personal View. PLoS Medicine, 8(8). DOI: 10.1371/journal.pmed.1001071
A news feature in Nature asks whether placebo controls are always a good idea: Why Fake It?
The piece looks at experimental neurosurgical treatments for Parkinson's, such as "Spheramine". This consists of cultured human cells, which are implanted directly into the brain of the sufferer. The idea is that the cells will grow and help produce dopamine, which is deficient in Parkinson's.
Peggy Willocks, a 44 year old teacher, took part in a trial of the surgery in 2000. She says it helped stave of........ Read more »
Katsnelson, A. (2011) Experimental therapies for Parkinson's disease: Why fake it?. Nature, 476(7359), 142-144. DOI: 10.1038/476142a
According to a new paper, yours truly is bipolar.
I've written before of my experience of depression, and the fact that I take antidepressants, but I've never been diagnosed with bipolar.
I've taken a few drugs in my time. On certain dopamine-based drugs I got euphoric, filled with energy, talkative, confident, with no need for sleep, and a boundless desire to do stuff, which is textbook hypomania. So I think I know what it feels like, and I can confidently say that it has never happened to m........ Read more »
Angst J, Azorin JM, Bowden CL, Perugi G, Vieta E, Gamma A, Young AH, & for the BRIDGE Study Group. (2011) Prevalence and Characteristics of Undiagnosed Bipolar Disorders in Patients With a Major Depressive Episode: The BRIDGE Study. Archives of general psychiatry, 68(8), 791-798. PMID: 21810644
What if there was a drug that didn't just affect the levels of chemicals in your brain, it turned off genes in your brain? That possibility - either exciting or sinister depending on how you look at it - could be remarkably close, according to a report just out from a Spanish group.The authors took an antidepressant, sertraline, and chemically welded it to a small interfering RNA (siRNA). A siRNA is kind of like a pair of genetic handcuffs. It selectively blocks the expression of a particular ge........ Read more »
Bortolozzi, A., Castañé, A., Semakova, J., Santana, N., Alvarado, G., Cortés, R., Ferrés-Coy, A., Fernández, G., Carmona, M., Toth, M.... (2011) Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects. Molecular Psychiatry. DOI: 10.1038/mp.2011.92
Antipsychotics, originally designed to control the hallucinations and delusions seen in schizophrenia, have been expanding their domain in recent years. Nowadays, they're widely used in bipolar disorder, depression, and as a new paper reveals, increasingly in anxiety disorders as well.The authors, Comer et al, looked at the NAMCS survey, which provides yearly data on the use of medications in visits to office-based doctors across the USA.Back in 1996, just 10% of visits in which an anxiety diso........ Read more »
Comer JS, Mojtabai R, & Olfson M. (2011) National Trends in the Antipsychotic Treatment of Psychiatric Outpatients With Anxiety Disorders. The American journal of psychiatry. PMID: 21799067
Brain maturation continues for longer than previously thought - well up until age 30. That's according to two papers just out, which may be comforting for those lamenting the fact that they're nearing the big Three Oh.This challenges the widespread view that maturation is essentially complete by the end of adolescence, in the early to mid 20s.Petanjek et al show that the number of dendritic spines in the prefrontal cortex increases during childhood and then rapidly falls during puberty - which p........ Read more »
Lebel C, & Beaulieu C. (2011) Longitudinal development of human brain wiring continues from childhood into adulthood. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(30), 10937-47. PMID: 21795544
Petanjek, Z., Judas, M., Simic, G., Rasin, M., Uylings, H., Rakic, P., & Kostovic, I. (2011) Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1105108108
According to the BBC, a new study has found that northern peoples have bigger eyes - and bigger brains.Actually, the paper in question talked about eyes but didn't make much of the brain finding, which is confined to the Supplement. Nonetheless, they did find an effect on brain size too. Peoples living further from the equator have larger eye sockets and also larger total cranial capacity (brain volume), apparantly. The authors include Robin Dunbar of "Dunbar's Number" fame.Their idea is that hu........ Read more »
Pearce, E., & Dunbar, R. (2011) Latitudinal variation in light levels drives human visual system size. Biology Letters. DOI: 10.1098/rsbl.2011.0570
"It's pretty painless. Basically you just need to lie there and make sure you don't move your head".This is what I say to all the girls... who are taking part in my fMRI studies. Head movement is a big problem in fMRI. If your head moves, your brain moves and all fMRI analysis assumes that the brain is perfectly still. Although head movement correction is now a standard part of any analysis software, it's not perfect.It may be a particular problem in functional connectivity studies, which attemp........ Read more »
Van Dijk, K., Sabuncu, M., & Buckner, R. (2011) The Influence of Head Motion on Intrinsic Functional Connectivity MRI. NeuroImage. DOI: 10.1016/j.neuroimage.2011.07.044
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