epression together with pain, but not pain alone, may increase activity in the immune system and inflammation. These are the important findings of a new study just published in the journal “Pain Medicine”.... Read more »
Kim Kristiansen, M.D. (2013) Pain and Depression Linked to the Immune System. Picture of Pain Blog. info:/
Shocker alert: medicines might have more effects than those listed on the patient information leaflet.I like being surprised. I particularly like being surprised about medicines and health, and how many of the medicines which even reside in the typical household medicines cabinet* might carry the potential to do so much more than that listed on the package insert. Leaking? @ Wikipedia Take for example the recent paper I bumped into by Sommansson and colleagues** continuing their ........ Read more »
Sommansson A, Wan Saudi WS, Nylander O, & Sjöblom M. (2013) Melatonin inhibits alcohol-induced increases in duodenal mucosal permeability in rats in vivo. American journal of physiology. Gastrointestinal and liver physiology. PMID: 23639810
A recently published paper in Scientific Reports has found that climate variability in the form of the North Atlantic Oscillation (NAO) has had a significant impact on the occurrence of disease outbreaks in Europe over the past fifty years. Researchers in France and the United Kingdom studied 2,058 outbreaks occurring in 36 countries from 114 infectious diseases from 1950 to 2009 and found that climatic variations and seasonal changes in air pressure across the continent attributed to the NAO in........ Read more »
Morand S, Owers KA, Waret-Szkuta A, McIntyre KM, & Baylis M. (2013) Climate variability and outbreaks of infectious diseases in Europe. Scientific reports, 1774. PMID: 23639950
If Valium makes you groggy, and Ambien makes you sleepwalk…
A compound that blocks a brain receptor you probably have never heard of may hold the key to the next generation of sleeping pills—and there is always a next generation of sleeping pills.
A new class of hypnotic compounds that serve as antagonists for the neurotransmitter orexin may combat insomnia without the “confusional arousals” that have come to plague some users of zolpidem, otherwise known as Ambien. Sleepwalking, s........ Read more »
Uslaner J. M., Tye S. J., Eddins D. M., Wang X., Fox S. V., Savitz A. T., Binns J., Cannon C. E., Garson S. L., & Yao L. (2013) Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition. Science Translational Medicine, 5(179), 179-179. DOI: 10.1126/scitranslmed.3005213
A particularly sinister aspect of drug addiction is relapse. To the ex-addict, environmental cues, life stressors and even the drug itself serve as the sirens’ call, beckoning them back into the deadly realm of abuse. Currently, doctors battle heroin temptations with psychotherapy and replacement opioid drugs, such as methadone. While effective, these treatments rely heavily [...]... Read more »
Schlosburg, J., Vendruscolo, L., Bremer, P., Lockner, J., Wade, C., Nunes, A., Stowe, G., Edwards, S., Janda, K., & Koob, G. (2013) Dynamic vaccine blocks relapse to compulsive intake of heroin. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1219159110
Sleep problems may increase your risk of prostate cancer, according to a new study. Get better sleep now with these simple tips.... Read more »
Sigurdardottir, L., Valdimarsdottir, U., Mucci, L., Fall, K., Rider, J., Schernhammer, E., Czeisler, C., Launer, L., Harris, T., Stampfer, M.... (2013) Sleep Disruption Among Older Men and Risk of Prostate Cancer. Cancer Epidemiology Biomarkers , 22(5), 872-879. DOI: 10.1158/1055-9965.EPI-12-1227-T
Coconut oil is being promoted by some as a “perfect” food. This is common in the CrossFit and Paleo communities. Coconut oil is like animal fat in that it isThe post Coconut oil and the search for the perfect diet. appeared first on WODMasters Stiff Competition.... Read more »
Enos RT, Davis JM, Velázquez KT, McClellan JL, Day SD, Carnevale KA, & Murphy EA. (2013) Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters. Journal of lipid research, 54(1), 152-63. PMID: 23103474
When you bring up the subject of listening to music while stoned, you get a range of responses, almost all of them positive. While you might enjoy a song in a non-altered state, under the influence of Cannabis, it has been established that listening to and creating music is somehow a deeper and more intense experience. The disputed issue that arises is why this happens and if the feeling is real.... Read more »
As consumers, we like to hear that produce growers and distributers go above and beyond food safety mandates to ensure that healthy fresh fruits and vegetables do not carry bacteria or viruses that can make us sick. But in California’s Salinas Valley, some more vigorous interventions are cutting into the last corners of wildlife habitat, without evidence of food safety benefits, creating tensions between wildlife preservation and food safety where none need exist.... Read more »
Sasha Gennet, Jeanette Howard, Jeff Langholz, Kathryn Andrews, Mark D Reynolds, & Scott A Morrison. (2013) Farm practices for food safety: an emerging threat to floodplain and riparian ecosystems. Frontiers in Ecology and the Environment, e-View ahead of print(May 6th). info:/10.1890/1202443
A lot has changed in the human body since our ancestors walked around on bare feet. We have less hair, we got bigger and we live longer, for example. But we’re still being haunted by some very stubborn diseases that survived the evolution. How is that possible?... Read more »
You’ve been hearing it for years; don’t eat too much sugar, because sugar rots your teeth. It turns out that sugar isn’t the real culprit behind tooth decay. Researchers, looking at the bacteria responsible for dental cavities, had found a molecule that can stop these common dental problems.
Jose Cordova, a Yale University researcher, and Erich Astudillo, from the University of Chile, identified the new molecule, called Keep32, that kills the Streptococcus Mutans bacteria an........ Read more »
Kind of a morbid question, but apparently one that is on many people’s minds. Suicide by drowning is definitely not impossible, although it is not the easiest method. Due to the body’s natural tendency to come up for air, drowning attempts are most likely to succeed in deep waters.... Read more »
Like Charlie Bucket looking through the sweet shop window at the delicious chocolates produced by the workforce of a certain Mr Willy Wonka (the candyman no less), I am always quite interested in the goings-on at the IMFAR autism research conference. The candyman can... @ Wikipedia This year (2013) proved to be a bit of a vintage, as once again the great and the good presented their Wonka bars of autism research; thus hinting at the direction of future autism research and what y........ Read more »
Höglund Carlsson, L., Norrelgen, F., Kjellmer, L., Westerlund, J., Gillberg, C., & Fernell, E. (2013) Coexisting Disorders and Problems in Preschool Children with Autism Spectrum Disorders. The Scientific World Journal, 1-6. DOI: 10.1155/2013/213979
We have differentiated between chromosomal versus hormonal influences on normal sleep and sleep rebounds in hermaphroditic mice. The neural mechanisms are TBD, however. ... Read more »
Ehlen, J., Hesse, S., Pinckney, L., & Paul, K. (2013) Sex Chromosomes Regulate Nighttime Sleep Propensity during Recovery from Sleep Loss in Mice. PLoS ONE, 8(5). DOI: 10.1371/journal.pone.0062205
A follow-up on Carl Zimmer's post in "Phenomena" (National Geographic) on 'Bugs as Drugs'.... Read more »
Hyman P, Atterbury R, & Barrow P. (2013) Fleas and smaller fleas: virotherapy for parasite infections. Trends in microbiology. PMID: 23540830
van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF, Tijssen JG.... (2013) Duodenal infusion of donor feces for recurrent Clostridium difficile. The New England journal of medicine, 368(5), 407-15. PMID: 23323867
Gray hair comes as a result of hydrogen peroxide accumulation in the hair follicles and the newly reported topical UVB-activated, pseudocatalase (PC-KUS) can help against the accumulation of hydrogen peroxide at the root level.
The FASEB Journal
"To date, it is beyond any doubt that the sudden loss of the inherited skin and localized hair color can affect those individuals in many fundamental ways," Karin U. Schallreuter, M.D., s........ Read more »
Schallreuter, K., Salem, M., Holtz, S., & Panske, A. (2013) Basic evidence for epidermal H2O2/ONOO--mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS. The FASEB Journal. DOI: 10.1096/fj.12-226779
Discussions on self-injurious behaviour (SIB) or auto-aggression are not normally for the faint-hearted.Indeed, as I intimated on a previous post on SIB and autism, when such behaviours are witnessed in children and young adults - even older adults, one does wonder what the effects might be not only on the person themselves but also on a parent or a sibling as they watch their own flesh and blood banging their head on a wall or pulling their hair out or trying to gouge their eyes out. I can't pu........ Read more »
Sisk RA, Motley WW 3rd, Yang MB, & West CE. (2013) Surgical outcomes following repair of traumatic retinal detachments in cognitively impaired adolescents with self-injurious behavior. Journal of pediatric ophthalmology and strabismus, 50(1), 20-6. PMID: 23061560
Did you ever take two or more antibiotics in order to get rid of a disease? New research in PLOS Biology suggests that this is not a wise thing to do. Drug resistant bacteria grow faster than their weaker counter parts when resources are limiting and many antibiotics are consumed.... Read more »
Pena-Miller R, Laehnemann D, Jansen G, Fuentes-Hernandez A, Rosenstiel P, Schulenburg H, & Beardmore R. (2013) When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition. PLoS biology, 11(4). PMID: 23630452
The benefits of taking fish oil and the harm caused by eating red meat, these two nutritional nuggets of wisdom have been passed around so much over the past few decades, we rarely stop to ask if they really do what people claim they do.
This month, two new papers on the subject of fish and meat have come forward from the University of Western Australia. The first examines the real impact of taking fish oil supplements on the diets of obese people.... Read more »
Wong, A., Chan, D., Ooi, E., Ng, T., Watts, G., & Barrett, P. (2013) Omega-3 fatty acid ethyl ester supplementation decreases very-low-density lipoprotein triacylglycerol secretion in obese men. Clinical Science, 125(1), 45-51. DOI: 10.1042/CS20120587
Koeth, R., Wang, Z., Levison, B., Buffa, J., Org, E., Sheehy, B., Britt, E., Fu, X., Wu, Y., Li, L.... (2013) Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine. DOI: 10.1038/nm.3145
Intravenous oxygen delivery that works?
Maybe temporary oxygenation, but not yet.
Will this change the approach to CICV (Can’t Intubate, Can’t Ventilate) patients?
No, but it may change the approach to CICO (Can’t Intubate, Can’t Oxygenate) patients.
The distinction is important. ... Read more »
Kheir, J., Scharp, L., Borden, M., Swanson, E., Loxley, A., Reese, J., Black, K., Velazquez, L., Thomson, L., Walsh, B.... (2012) Oxygen Gas-Filled Microparticles Provide Intravenous Oxygen Delivery. Science Translational Medicine, 4(140), 140-140. DOI: 10.1126/scitranslmed.3003679
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