Chemistry posts
- July 23, 2012
- 07:00 PM
- 248 views
Science on crack: the chemistry of illegal drugs, 1
by Puff the Mutant Dragon in Puff the Mutant Dragon
I have a confession to make: I love illegal drugs.... Read more »
Jatlow P. (1988) Cocaine: analysis, pharmacokinetics, and metabolic disposition. The Yale journal of biology and medicine, 61(2), 105-13. PMID: 3043924
- July 22, 2012
- 07:48 PM
- 354 views
Getting leaner with Brown Fat, Thermogenisis and Chilli Sauce?
by mc in begin to dig (b2d)
Is hot sauce hot enough to burn fat? Maybe - if we have "active" brown fat.
A lot of us look for ways to boost fat burning or to stop fat from being created in the first place on our quest for getting lean and staying lean. Alpha lipoic acid from 800mg [1] to 1800mg a day [2], alpha lipoic acid with CoQ10 even [3] looks at interrupting fat creation. Then there's thermogenisis, getting some heat up in the system to burn fat mobilized for use as energy. There are a number of fo........ Read more »
Carbonelli MG, Di Renzo L, Bigioni M, Di Daniele N, De Lorenzo A, & Fusco MA. (2010) Alpha-lipoic acid supplementation: a tool for obesity therapy?. Current pharmaceutical design, 16(7), 840-6. PMID: 20388095
Wagner AE, Ernst IM, Birringer M, Sancak O, Barella L, & Rimbach G. (2012) A Combination of Lipoic Acid Plus Coenzyme Q10 Induces PGC1α, a Master Switch of Energy Metabolism, Improves Stress Response, and Increases Cellular Glutathione Levels in Cultured C2C12 Skeletal Muscle Cells. Oxidative medicine and cellular longevity, 835970. PMID: 22655115
Koh EH, Lee WJ, Lee SA, Kim EH, Cho EH, Jeong E, Kim DW, Kim MS, Park JY, Park KG.... (2011) Effects of alpha-lipoic Acid on body weight in obese subjects. The American journal of medicine, 124(1), 850-8. PMID: 21187189
Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y, Sato H, & Takahashi M. (2009) Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. The American journal of clinical nutrition, 89(1), 45-50. PMID: 19056576
Galgani JE, Ryan DH, & Ravussin E. (2010) Effect of capsinoids on energy metabolism in human subjects. The British journal of nutrition, 103(1), 38-42. PMID: 19671203
Yoneshiro T, Aita S, Kawai Y, Iwanaga T, & Saito M. (2012) Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. The American journal of clinical nutrition, 95(4), 845-50. PMID: 22378725
Ouellet V, Labbé SM, Blondin DP, Phoenix S, Guérin B, Haman F, Turcotte EE, Richard D, & Carpentier AC. (2012) Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. The Journal of clinical investigation, 122(2), 545-52. PMID: 22269323
Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y, & Saito M. (2011) Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity (Silver Spring, Md.), 19(1), 13-6. PMID: 20448535
Cao L, Choi EY, Liu X, Martin A, Wang C, Xu X, & During MJ. (2011) White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis. Cell metabolism, 14(3), 324-38. PMID: 21907139
- July 20, 2012
- 04:16 PM
- 294 views
Researchers find new anti-malarial drug target
by admin in Beaker
An international team of scientists, including researchers at the University of California, San Diego and Sanford-Burnham Medical Research Institute, have identified the first reported inhibitors of a key enzyme involved in survival of the parasite responsible for malaria.... Read more »
Janina Preuss, Patrick Maloney, Satyamaheshwar Peddibhotla, Michael P. Hedrick, Paul Hershberger, Palak Gosalia, Monika Milewski, Yujie Linda Li, Eliot Sugarman, Becky Hood.... (2012) Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces paras. Journal of Medicinal Chemistry. info:/10.1021/jm300833h
- July 19, 2012
- 12:59 PM
- 367 views
The Soot Line: Between fire and ice
by Invader Xan in Supernova Condensate
The question of precisely what happens as stars and planets condense from vast clouds of gas is still very much an unanswered one. We have some good ideas of how things work, but really it’s difficult to be certain. Newly … Continue reading →... Read more »
Kress, Monika E., Tielens, Alexander G. G. M., & Frenklach, Michael. (2010) The ‘soot line’: Destruction of presolar polycyclic aromatic hydrocarbons in the terrestrial planet-forming region of disks. Advances in Space Research, 46(1), 44-49. DOI: 10.1016/j.asr.2010.02.004
- July 19, 2012
- 10:42 AM
- 499 views
The Accretionary Wedge #48 - Atomic Geology
by Matt Herod in GeoSphere
This month the Accretionary Wedge is being hosted by Charles Carrigan at Earth-like Planet. It is the 48th edition of AW and the topic is "Geoscience and Technology". The technology used by geoscientists has matured over the centuries. It began simply, with compasses, maps, sketchpads and pencils. However, now it has entered into a digital world in which geology is practised with satellites, lasers and instruments with all sorts of fancy sounding acronyms such as ICP-MS, LA-I........ Read more »
Ragnar Hellborg and Goran Skog. (2008) Accelerator Mass Spectrometry. Mass Spectrometry Reviews, 398-427. DOI: 10.1002/mas.20172
- July 18, 2012
- 05:57 PM
- 490 views
The Summer Olympics and the “War on Doping”
by Dirk Hanson in Addiction Inbox
Time for a change in strategy?
The Summer Olympics are fast approaching, and that can only mean one thing: drugs. After more than a decade, you might wonder, how goes the so-called “War on Doping?”
Not so good, but thanks for asking. The World Anti-Doping Agency, established in 1999 and backed by the UNESCO anti-doping convention, will be operating 24/7 during the games, protecting the “purity” of Sport, trying to ferret out everything from cannabis and cocaine to steroids and ........ Read more »
Kayser B, & Broers B. (2012) The Olympics and harm reduction?. Harm reduction journal, 9(1), 33. PMID: 22788912
- July 10, 2012
- 03:45 AM
- 186 views
Arylethynylenes in Photovoltaics
by postgradsci in interested in science?
A Chem. Comm. out online towards the end of June reports on the use of an arylethynylene in a solution-processable solar cell. Arylethynylenes can best be described by an example: [...]... Read more »
Shin et al. (2012) J-aggregation Induced Low Bandgap Anthracene-based Conjugated Molecule for Solution-processed Solar Cells. Chem. Comm. DOI: 10.1039/c2cc34109c
- July 6, 2012
- 01:20 PM
- 365 views
Meet the NanoPutians
by Melissa Chernick in Science Storiented
It is always nice to be reminded that science can have a sense of humor. For instance, I know that biology has a long history of naming insects after famous people including movie stars (such as the dolichopodid fly Campsicnemius charliechaplini), writers (like the dinosaur Serendipaceratops arthurclarkei), musicians (such as the trilobites Avalachurus lennoni, A. starri, and Struszia mccartneyi), science educators (like the land snail Crikey steveirwini), and even fictional characters (such ........ Read more »
Stephanie H. Chanteau, & James M. Tour. (2003) Synthesis of Anthropomorphic Molecules: The NanoPutians. The Journal of Organic Chemistry, 68(23), 8750-8766. DOI: 10.1021/jo0349227
- July 5, 2012
- 05:29 PM
- 278 views
Ferroptosis, another way cells die
by Clay Clark in Biochem Blogs
There are a number of processes that lead to the death of a cell: apoptosis, necrosis, and autophagy are the primary mechanisms – each has a distinct biochemical and morphological fingerprint. In a new paper by Brent Stockwell’s lab at … Continue reading →... Read more »
Dixon Scott J., Lemberg Kathryn M., Lamprecht Michael R., Skouta Rachid, Zaitsev Eleina M., Gleason Caroline E., Patel Darpan N., Bauer Andras J., Cantley Alexandra M., & Yang Wan Seok. (2012) Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death. Cell, 149(5), 1072. DOI: 10.1016/j.cell.2012.03.042
Dolma Sonam, Lessnick Stephen L, Hahn William C, & Stockwell Brent R. (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell, 3(3), 296. DOI: 10.1016/S1535-6108(03)00050-3
Yang Wan Seok, & Stockwell Brent R. (2008) Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chemistry , 15(3), 245. DOI: 10.1016/j.chembiol.2008.02.010
- June 29, 2012
- 04:42 PM
- 427 views
How fireworks light up the sky
by Cath in Basal Science (BS) Clarified
Many countries/regions will be celebrating their national/independence day over the weekend and into next week, so you’ll likely have a chance to see some fireworks whether in person, on television, [...]... Read more »
Roncone, K. (2004) Things that go boom in the night: The art and science of fireworks. JOM JOURNAL OF THE MINERALS, METALS AND MATERIALS SOCIETY. DOI: 10.1007/s11837-004-0084-8
- June 27, 2012
- 03:35 PM
- 500 views
Steroids Won't Help If You're a Loser
by Miss Behavior in The Scorpion and the Frog
The more we study physiology and behavior across groups of animals, the more we find we have in common in the types of behaviors we express and the biological machinery of how our bodies influence what behaviors are expressed and when. But similarity does not mean the same. Sometimes seemingly small physiological differences can have big behavioral consequences. A snuggly California mouse pair. Photo from the Marler lab.A lone wire-walking white-footed mouse. Photo by the National Park Service.T........ Read more »
Fuxjager MJ, Montgomery JL, & Marler CA. (2011) Species differences in the winner effect disappear in response to post-victory testosterone manipulations. Proceedings. Biological sciences / The Royal Society, 278(1724), 3497-503. PMID: 21490015
Oyegbile TO, & Marler CA. (2005) Winning fights elevates testosterone levels in California mice and enhances future ability to win fights. Hormones and behavior, 48(3), 259-67. PMID: 15979073
- June 27, 2012
- 09:03 AM
- 367 views
Video Tip of the Week: The PSI SBKB’s New Content Hubs
In today’s tip I will feature the newly organized content hubs over at the Protein Structure Initiative’s Structural Biology Knowledgebase, or PSI SBKB. We do have a free, full-length tutorial on the PSI SBKB that we are in the process of updating, but I thought I’d just touch on one of the new updates to [...]... Read more »
Gifford LK, Carter LG, Gabanyi MJ, Berman HM, & Adams PD. (2012) The Protein Structure Initiative Structural Biology Knowledgebase Technology Portal: a structural biology web resource. Journal of structural and functional genomics, 13(2), 57-62. PMID: 22527514
Gabanyi MJ, Adams PD, Arnold K, Bordoli L, Carter LG, Flippen-Andersen J, Gifford L, Haas J, Kouranov A, McLaughlin WA.... (2011) The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods. Journal of structural and functional genomics, 12(2), 45-54. PMID: 21472436
Cormier CY, Park JG, Fiacco M, Steel J, Hunter P, Kramer J, Singla R, & LaBaer J. (2011) PSI:Biology-materials repository: a biologist's resource for protein expression plasmids. Journal of structural and functional genomics, 12(2), 55-62. PMID: 21360289
- June 17, 2012
- 05:31 PM
- 494 views
Totally Tropical Titan
by Invader Xan in Supernova Condensate
Our solar system is full of mysteries, and it seems the more we look, the more we find, and the less we can explain. Most recently, the puzzles of the martian methane and the beautifully lethal venusian clouds have been … Continue reading →... Read more »
C.P. McKay, & H.D. Smith. (2005) Possibilities for methanogenic life in liquid methane on the surface of Titan. Icarus, 274-276. DOI: 10.1016/j.icarus.2005.05.018
Giuseppe Mitri, Adam P. Showman, Jonathan I. Lunine, & Ralph D. Lorenz. (2007) Hydrocarbon lakes on Titan. Icarus, 385-394. DOI: 10.1016/j.icarus.2006.09.004
Francois Raulin. (2008) Astrobiology and Habitability of Titan. Space Sci Rev, 37-48. DOI: 10.1007/s11214-006-9133-7
Darrell F. Strobel. (2010) Molecular hydrogen in Titan's atmosphere: Implications of the measured tropospheric and thermospheric mole fractions. Icarus, 878-886. DOI: 10.1016/j.icarus.2010.03.003
- June 13, 2012
- 01:52 PM
- 593 views
The Age of Aquariums: Amazing Animal Watching Vacations Part 2
by Miss Behavior in The Scorpion and the Frog
Below the ocean’s surface is a world more mysterious than the dark side of the moon and with more animal diversity than the Amazon rainforest. Over 70% of our planet is covered in ocean, yet fully 95% of our oceans remain completely unexplored. But we do know that the habitats animals adapt to are more vast than the open ocean (In fact, many more animals are by the coasts than out in the open ocean). There are shallow sunlit coastal waters and deep dark ocean trenches, coral reefs, estuaries, ........ Read more »
GRAY, J. (1997) Marine biodiversity: patterns, threats and conservation needs. Biodiversity and Conservation, 6(1), 153-175. DOI: 10.1023/a:1018335901847
Orcutt, B., Sylvan, J., Knab, N., & Edwards, K. (2011) Microbial Ecology of the Dark Ocean above, at, and below the Seafloor. Microbiology and Molecular Biology Reviews, 75(2), 361-422. DOI: 10.1128/MMBR.00039-10
Zeppilli, D., Mea, M., Corinaldesi, C., & Danovaro, R. (2011) Mud volcanoes in the Mediterranean Sea are hot spots of exclusive meiobenthic species. Progress In Oceanography, 91(3), 260-272. DOI: 10.1016/j.pocean.2011.01.001
- June 12, 2012
- 06:10 PM
- 382 views
Toxic and toothsome: a tale of two wild Asteraceae
by aewills in A Bouquet From Mendel
Toxic Interloper: Not long ago, I planted a bunch of coriander/cilantro seeds in my back yard. When the seedlings emerged, I found not only cilantro, but also this: Senecio vulgaris, known as common groundsel to me, but also as Old-man-of-the-spring. … Continue reading →... Read more »
Wang, C., Li, Y., Gao, J., He, Y., Xiong, A., Yang, L., Cheng, X., Ma, Y., & Wang, Z. (2011) The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. Analytical and Bioanalytical Chemistry, 401(1), 275-287. DOI: 10.1007/s00216-011-5075-3
- June 6, 2012
- 12:29 PM
- 420 views
Etched in Bone: Uncovering information about immigrants to Rome
by Kristina Killgrove in Powered By Osteons
I just returned from Holland, where I spent a lovely few days talking to all manner of experts on ancient Rome during the Moving Romans conference and thanatouring Leiden's excellent Museum Boerhaave and the Rijksmuseum van Oudheden.
My own contribution to the conference was called "Etched in Bone," and I both summarized some of my recent research on identifying immigrants to Rome (which I've previously blogged about here, here, here, and here - whew!) and expanded on that work by including som........ Read more »
Montgomery, J., Evans, J.A., Chenery, S.R., Pashley, V., & Killgrove, K. (2010) 'Gleaming, white and deadly' : using lead to track human exposure and geographic origins in the Roman period in Britain. Journal of Roman Archaeology, 199-226. info:/
Turner BL, & Armelagos GJ. (2012) Diet, residential origin, and pathology at Machu Picchu, Peru. American journal of physical anthropology. PMID: 22639369
- June 6, 2012
- 09:35 AM
- 539 views
Interstellar Sleuths
by Invader Xan in Supernova Condensate
“Of course, this identification is simply wrong.” That one remark caused a subdued but audible commotion in the audience, and a handful of shocked responses to be posted on twitter. The remark in question had been made by Jacek Krełowski, … Continue reading →... Read more »
Harvey Liszt, Paule Sonnentrucker, Martin Cordiner, & Maryvonne Gerin. (2012) The abundance of C3H2 and other small hydrocarbons in the diffuse interstellar medium. ApJL. arXiv: 1206.0342v1
- June 4, 2012
- 11:54 AM
- 464 views
Awwww, Ain’t That Sweet?
by Amy Hendricksen in Promega Connections
There are many things that I love about summer…being out on the water, puttering around in my garden, and local festivals top the list. But the best, the absolute best, is the produce. I could (and have!) spent hours at the farmer’s market, admiring the myriad of colors and varietals laid out under crisp white [...]... Read more »
Tieman, D., Bliss, P., McIntyre, L., Blandon-Ubeda, A., Bies, D., Odabasi, A., Rodríguez, G., van der Knaap, E., Taylor, M., Goulet, C.... (2012) The Chemical Interactions Underlying Tomato Flavor Preferences. Current Biology. DOI: 10.1016/j.cub.2012.04.016
- June 3, 2012
- 12:01 PM
- 663 views
A Tale of Two Huxleys
by TheCellularScale in The Cellular Scale
Andrew Huxley is one of the founders of both modern electrophysiology and computational neuroscience, and is consequently a personal hero of mine. His recent (May 30, 2012) death inspired me to learn more about his life.Andrew Huxley (1917-2012)Andrew Huxley along with Alan Hodgkin discovered the mechanisms which governed the action potential in nerve cells. They inserted micro-electrodes into the squid giant axon and recorded the sodium and potassium currents which generated ........ Read more »
HODGKIN AL, & HUXLEY AF. (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology, 117(4), 500-44. PMID: 12991237
- May 29, 2012
- 03:22 PM
- 364 views
Using computer simulation to find hub proteins as biomarkers for human cancer
by Clay Clark in Biochem Blogs
Recently I posted a blog on using miRNA profiling as biomarkers for cancer. Protein profiling is another potential tool for hunting biomarkers. Traditional microarray data are based on the assumption that each individual protein contributes independently to clinical outcomes. … Continue reading →... Read more »
Chuang, H., Lee, E., Liu, Y., Lee, D., & Ideker, T. (2007) Network-based classification of breast cancer metastasis. Molecular Systems Biology. DOI: 10.1038/msb4100180
Li, C., & Li, H. (2008) Network-constrained regularization and variable selection for analysis of genomic data. Bioinformatics, 24(9), 1175-1182. DOI: 10.1093/bioinformatics/btn081
Chen, L., Xuan, J., Riggins, R., Clarke, R., & Wang, Y. (2011) Identifying cancer biomarkers by network-constrained support vector machines. BMC Systems Biology, 5(1), 161. DOI: 10.1186/1752-0509-5-161
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