Today, gold and gold nanoparticles can be found almost everywhere, including personal care products, solar cells, rheumatoid arthritis drugs, MRI contrast agents etc. Generally, gold is universally recognised as the most inert of metals. However, a new study suggests that gold nanoparticles actually interact with our adipose stem cells, inhibiting their function and causing aging, wrinkling, slowed wound healing and even the onset of diabetes.Read More... Read more »
Mironava, T., Hadjiargyrou, M., Simon, M., & Rafailovich, M. (2013) Gold nanoparticles cellular toxicity and recovery: Adipose Derived Stromal cells. Nanotoxicology, 1-13. DOI: 10.3109/17435390.2013.769128
T’is the season of finals again, and with it, a surging interest in prescription “smart drugs” (see Fig 1). High school and college students are increasingly turning to ADHD medicine (Ritalin, Adderall) in hopes of enhancing school and test performance. Intuitively this makes sense: drugs that increase energy, attention and concentration should inevitably lead to [...]... Read more »
Lakhan SE, & Kirchgessner A. (2012) Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects. Brain and behavior, 2(5), 661-77. PMID: 23139911
Smith ME, & Farah MJ. (2011) Are prescription stimulants "smart pills"? The epidemiology and cognitive neuroscience of prescription stimulant use by normal healthy individuals. Psychological bulletin, 137(5), 717-41. PMID: 21859174
Last March, Dr. Deborah Persaud, from the John's Hopkins Children Center, presented a stunning finding at the conference CROI, receiving great resonance across several newscasts: Persaud reported the first case of infant functionally cured of HIV. You can watch Persaud's presentation by downloading the podcast here, it's the seventh talk of the session "Is there hope for HIV eradication?"Up until this finding, the only living person cured from HIV was the Berlin Patient, who was cured after rece........ Read more »
Persaud, D., Palumbo, P., Ziemniak, C., Hughes, M., Alvero, C., Luzuriaga, K., Yogev, R., Capparelli, E., & Chadwick, E. (2012) Dynamics of the resting CD4 T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age. AIDS, 26(12), 1483-1490. DOI: 10.1097/QAD.0b013e3283553638
Sáez-Cirión, A., Bacchus, C., Hocqueloux, L., Avettand-Fenoel, V., Girault, I., Lecuroux, C., Potard, V., Versmisse, P., Melard, A., Prazuck, T.... (2013) Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study. PLoS Pathogens, 9(3). DOI: 10.1371/journal.ppat.1003211
What causes fatigue? And why is it sometimes so hard to push through it? Few people enjoy the sensations of fatigue and pain that accompany intense exercise. While endurance athletesThe post What causes fatigue? Why is it different in CrossFit? appeared first on WODMasters Stiff Competition.... Read more »
Bassini A, Magalhães-Neto AM, Sweet E, Bottino A, Veiga C, Tozzi MB, Pickard MB, & Cameron LC. (2013) Caffeine Decreases Systemic Urea in Elite Soccer Players during Intermittent Exercise. Medicine and science in sports and exercise, 45(4), 683-690. PMID: 23135367
Wilkinson DJ, Smeeton NJ, & Watt PW. (2010) Ammonia metabolism, the brain and fatigue; revisiting the link. Progress in neurobiology, 91(3), 200-19. PMID: 20138956
Bassini-Cameron, A., Monteiro, A., Gomes, A., Werneck-de-Castro, J., & Cameron, L. (2008) Glutamine protects against increases in blood ammonia in football players in an exercise intensity-dependent way. British Journal of Sports Medicine, 42(4), 260-266. DOI: 10.1136/bjsm.2007.040378
Researchers found that the patients with heart problems, known as STEMI, already admitted in the hospital have 10 times more chances of dying from heart attack as compared to the patients, who get heart attack outside of the hospital and taken to the hospital quickly.
Journal of the American Heart Association
World is full of strange events but humanity is even more strange. Researchers from University of North Carolina (UNC) School of Medici........ Read more »
Dai X, Bumgarner J, Spangler A, Meredith D, Smith SC, & Stouffer GA. (2013) Acute ST-Elevation Myocardial Infarction in Patients Hospitalized for Noncardiac Conditions. Journal of the American Heart Association, 2(2). PMID: 23557748
When most people think of bulimia nervosa, they think of binge eating and self-induced vomiting. While that is not incorrect, it is not the full picture either. In the current edition of the Diagnostic and Statistical Manual (DSM-IV), there are two subtypes of bulimia nervosa: purging (BN-P) and nonpurging (BN-NP). The difference lies in the types of compensation methods: patients with BN-P engage in self-induced vomiting, or the misuse of laxatives, diuretics, or enemas whereas patients with BN........ Read more »
van Hoeken, D., Veling, W., Sinke, S., Mitchell, J., & Hoek, H. (2009) The validity and utility of subtyping bulimia nervosa. International Journal of Eating Disorders, 42(7), 595-602. DOI: 10.1002/eat.20724
Researchers found that the U.S. hospitals get more profit when the surgery goes wrong as compared to the condition when all the tasks go well and patients go home without any complications.
The Journal of the American Medical Association (JAMA)
Quite disturbing report but one of the points to consider in healthcare system is that the finances spent on that industry have to be properly planned.
Do you know nearly $400 billion is spent on the s........ Read more »
Eappen, S. (2013) Relationship Between Occurrence of Surgical Complications and Hospital Finances. JAMA, 309(15), 1599. DOI: 10.1001/jama.2013.2773
In a new study on mice, researchers from the RIKEN Institute, Japan have discovered a compound that could be used to prevent cancer relapse in acute myeloid leukaemia (AML) patients, especially the ones carrying the FLT3-ITD mutation.Read More... Read more »
Saito, Y., Yuki, H., Kuratani, M., Hashizume, Y., Takagi, S., Honma, T., Tanaka, A., Shirouzu, M., Mikuni, J., Handa, N.... (2013) A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo. Science Translational Medicine, 5(181), 181-181. DOI: 10.1126/scitranslmed.3004387
Yesterday at "The Paramedic's Edge," this was the topic of discussion of a possible use of NTG (NiTroGlycerin – GTN GlycerylTriNitrate in Commonwealth countries).
NTG is a vasodilator and sepsis is a vasodialtion problem. There are other problems with sepsis, but vasodilation may be the primary problem.... Read more »
Guglin, M., & Postler, G. (2009) High dose nitroglycerin treatment in a patient with cardiac arrest: a case report. Journal of Medical Case Reports, 3(1), 8782. DOI: 10.4076/1752-1947-3-8782
Spronk, P., Ince, C., Gardien, M., Mathura, K., Straaten, H., & Zandstra, D. (2002) Nitroglycerin in septic shock after intravascular volume resuscitation. The Lancet, 360(9343), 1395-1396. DOI: 10.1016/S0140-6736(02)11393-6
In a new study, a research team from the University of Pittsburgh School of Medicine and the National Institutes of Health (NIH), has presented a new, simplified method for growing stem cells. The method works by inhibiting a specific membrane protein, called CD47. The researchers say that their method, unlike the currently available ones, requires less ingredients, e.g. cells and agents, to support cell growth.Read More... Read more »
Kaur, S., Soto-Pantoja, D., Stein, E., Liu, C., Elkahloun, A., Pendrak, M., Nicolae, A., Singh, S., Nie, Z., Levens, D.... (2013) Thrombospondin-1 Signaling through CD47 Inhibits Self-renewal by Regulating c-Myc and Other Stem Cell Transcription Factors. Scientific Reports. DOI: 10.1038/srep01673
A key element in discovering valid mental disorder categories is to differentiate a mental disorder from other valid mental disorder categories.Biological markers for mental disorders have been slow to develop. Functional brain imaging techniques and other research tools are evolving to help in the important task of improving the validity of clinical neuroscience disorders.Adjustment disorder is a relatively common condition that has lagged in research attention. Adjustment disorder ........ Read more »
Jeong HG, Ko YH, Han C, Kim YK, & Joe SH. (2013) Distinguishing Quantitative Electroencephalogram Findings between Adjustment Disorder and Major Depressive Disorder. Psychiatry investigation, 10(1), 62-8. PMID: 23482820
This week’s video Tip of the Week offers you a quick tour of GISAID’s resources and their EpiFlu™ database. This is the database you might be hearing about in the news—the one to which researchers submit the new H7N9 influenza sequence data that they are collecting. Originally this initiative was seeded as the “Global Initiative [...]... Read more »
Gao, R., Cao, B., Hu, Y., Feng, Z., Wang, D., Hu, W., Chen, J., Jie, Z., Qiu, H., Xu, K.... (2013) Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1304459
"If you've met one person with autism, you've met one person with autism" so the oft-cited phrase goes. The implication is that whilst unified under the label of presenting with the triad/dyad characteristics of an autism spectrum condition, the heterogeneity present across the spectrum coupled with other comorbidity, allied to factors such as genes, personality, temperament, maturation, environment et al, mean that everyone is different and importantly everyone is dynamic.Umbrella under an........ Read more »
Moreno-De-Luca A, Myers SM, Challman TD, Moreno-De-Luca D, Evans DW, & Ledbetter DH. (2013) Developmental brain dysfunction: revival and expansion of old concepts based on new genetic evidence. Lancet neurology, 12(4), 406-14. PMID: 23518333
Take Home Message: Whole body vibration therapy may improve strength and postural control among post-ACL reconstruction patients as an adjunctive therapy to rehabilitation.
Deficits in strength, proprioception, and postural control are often evident post anterior cruciate ligament (ACL) reconstruction and can last from 6-months to 4-years post-surgery. Whole-body vibration therapy (WBVT) improves balance and postural control in many populations, and if introduced early after an ACL reconstru........ Read more »
Fu CL, Yung SH, Law KY, Leung KH, Lui PY, Siu HK, & Chan KM. (2013) The effect of early whole-body vibration therapy on neuromuscular control after anterior cruciate ligament reconstruction: a randomized controlled trial. The American Journal of Sports Medicine, 41(4), 804-14. PMID: 23460328
A new study on rodents by a collaborative team of researchers from Osiris Therapeutics and Novartis Research indicates that mesenchymal stem cells (MSCs) may be a better treatment for rheumatoid arthritis (RA) than the currently available drugs are.Read More... Read more »
LINDAN. LIU, GANGWANG, KYLEHENDRICKS, KEUNMYOUNG LEE, ERNST BOHNLEIN, UWE JUNKER, & JOSEPH D. MOSCA. (2013) Comparison of Drug and Cell-Based Delivery: Engineered Adult Mesenchymal Stem Cells Expressing Soluble Tumor Necrosis Factor Receptor II Prevent Arthritis in Mouse and Rat Animal Models. Stem Cells Translational Medicine. info:/10.5966/sctm.2012-0135
Bioengineered rat kidneys developed by Massachusetts General Hospital investigators successfully produced urine both in a laboratory apparatus and after being transplanted into living animals.... Read more »
Kory Dodd Zhao. (2013) Mass. General team develops implantable, bioengineered rat kidney. Massachusetts General Hospital . info:/
Everybody remembers the kind captain in Titanic, drowning in his own guilt when he realises he has comprised safety regulations for fame, and his decision to go down with the ship. Before meeting his demise, he first makes sure the women and children make it off the ship. Surely this is the proper thing to do in such situations – women and children first- right? Research suggests otherwise.... Read more »
Bruno S. Frey, David A. Savage, and Benno Torgler. (2010) Behavior under Extreme Conditions: The Titanic Disaster. Journal of Economic Perspective. info:/
Bush SP. (2004) Snakebite suction devices don't remove venom: they just suck. Annals of emergency medicine, 43(2), 187-8. PMID: 14747806
Stem cell therapies are taking off, in a surprisingly unregulated way. While most humans have to go to places like South Korea to receive them, horses, dogs, cats, pigs and tigers are already being treated in North America. The most … Continue reading →... Read more »
Corselli, M., Chin, C., Parekh, C., Sahaghian, A., Wang, W., Ge, S., Evseenko, D., Wang, X., Montelatici, E., Lazzari, L.... (2013) Perivascular support of human hematopoietic stem/progenitor cells. Blood, 121(15), 2891-2901. DOI: 10.1182/blood-2012-08-451864
Glettig, D.L., & Kaplan, D.L. (2013) Extending Human Hematopoietic Stem Cell Survival In Vitro with Adipocytes. BioResearch Open Access. info:/
Impact Reduction Through Changing to Midfoot Strike Pattern vs Low Drop Footwear... Read more »
Giandolini M, Horvais N, Farges Y, Samozino P, & Morin JB. (2013) Impact reduction through long-term intervention in recreational runners: midfoot strike pattern versus low-drop/low-heel height footwear. European journal of applied physiology. PMID: 23584279
A new study published by researchers at the University of California, (UCLA) shows that the elasticity of the physical matrix used for growing heart muscle cells (cardiomyocytes) in the laboraty, is a key-factor for the success of cardiac tissue engineering.Read More... Read more »
Arshi, A., Nakashima, Y., Nakano, H., Eaimkhong, S., Evseenko, D., Reed, J., Stieg, A., Gimzewski, J., & Nakano, A. (2013) Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. Science and Technology of Advanced Materials, 14(2), 25003. DOI: 10.1088/1468-6996/14/2/025003
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