Take Home Message: Elite soccer athletes may be at an increased risk for knee and ankle osteoarthritis compared with the general population. This group should be identified as high risk and preventative measures should be taken.
While participation in elite-level sports is often viewed as a good thing, there is an established increased risk of short-term injuries (e.g., sprains, strains). This increased injury risk may leave athletes at an increased risk for long-term disability (e.g., oste........ Read more »
Kuijt, M., Inklaar, H., Gouttebarge, V., & Frings-Dresen, M. (2012) Knee and ankle osteoarthritis in former elite soccer players: A systematic review of the recent literature. Journal of Science and Medicine in Sport, 15(6), 480-487. DOI: 10.1016/j.jsams.2012.02.008
The Irish poet Brendan Behan is, I think, credited with the phrase: "There's no bad publicity except an obituary". One wonders how appropriate this phrase might be to the 'diagnostic Bible' (except that it isn't) which is DSM-V which is poised to make its entrance into the World in the coming days.The real Homer @ Wikipedia Indeed, the story of DSM-V even before it hits the diagnostic shelves of all good psychiatric bookshops, has the makings of an epic piece of poetry or literature, o........ Read more »
Ian B Hickie1, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier, & Patrick D McGorry. (2013) Clinical classification in mental health at the cross-roads: which direction next?. BMC Medicine, 126. info:/
Unlike most vertebrates which can replace lost teeth through their entire lives, humans come with only two sets, baby teeth and adult teeth, then they simply lose the ability for tooth renewal.. However, a new study on alligators by researchers at the Keck School of Medicine, University of Southern California (USC) may someday allow doctors to stimulate tooth regeneration in humans as well.Read More... Read more »
Wu, P., Wu, X., Jiang, T., Elsey, R., Temple, B., Divers, S., Glenn, T., Yuan, K., Chen, M., Widelitz, R.... (2013) Specialized stem cell niche enables repetitive renewal of alligator teeth. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1213202110
This week, 13th-19th May, a campaign is being launched to highlight the hidden aspects of brain injury and help with the correct diagnosis of these potentially terminal conditions. The campaign is part of Action for Brain Injury (ABI) week, organised by Headway.
Brain injury is an umbrella-term for a number of conditions, including brain trauma, stroke and brain tumours. These conditions can often go unnoticed externally, yet are extremely damaging internally. It is therefore vital that GPs c........ Read more »
Ahmed, A., Thaci, B., Alexiades, N., Han, Y., Qian, S., Liu, F., Balyasnikova, I., Ulasov, I., Aboody, K., & Lesniak, M. (2011) Neural Stem Cell-based Cell Carriers Enhance Therapeutic Efficacy of an Oncolytic Adenovirus in an Orthotopic Mouse Model of Human Glioblastoma. Molecular Therapy, 19(9), 1714-1726. DOI: 10.1038/mt.2011.100
These days, we have a pretty serious problem when it comes to our ability to kill resistant bacteria causing serious illness. People petition governments to urge action, while drug companies lament over how those pesky bacteria evolved to defeat their … Continue reading →... Read more »
Johnston BC, Ma SS, Goldenberg JZ, Thorlund K, Vandvik PO, Loeb M, & Guyatt GH. (2012) Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Annals of internal medicine, 157(12), 878-88. PMID: 23362517
Karuppiah P, & Rajaram S. (2012) Antibacterial effect of Allium sativum cloves and Zingiber officinale rhizomes against multiple-drug resistant clinical pathogens. Asian Pacific journal of tropical biomedicine, 2(8), 597-601. PMID: 23569978
Genome of the western painted turtle has developed a remarkable ability to go without oxygen for months. And this genomic change could point to better heart attack and stroke treatments for us.... Read more »
Abramyan, J., Badenhorst, D., Biggar, K., Borchert, G., Botka, C., Bowden, R., Braun, E., Bronikowski, A., Bruneau, B., Buck, L.... (2013) The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biology, 14(3). DOI: 10.1186/gb-2013-14-3-r28
Running Asymmetry, Loading Rate and Injury Risk... Read more »
Bredeweg, S., Buist, I., & Kluitenberg, B. (2013) Differences in kinetic asymmetry between injured and noninjured novice runners: A prospective cohort study. Gait . DOI: 10.1016/j.gaitpost.2013.04.014
It's a well known fact that exercise induces stem cells in the hippocampus, a important brain area, to become neurons, a process known as neurogenesis However, up until now little was known about the deeper mechanisms involved in this process. Now, a new study on mice by researchers at the Max Delbrück Centre (MDC), Berlin-Buch reveals that serotonin plays a direct role in exercise-induced neurogenesis.Read More... Read more »
Klempin, F., Beis, D., Mosienko, V., Kempermann, G., Bader, M., & Alenina, N. (2013) Serotonin Is Required for Exercise-Induced Adult Hippocampal Neurogenesis. Journal of Neuroscience, 33(19), 8270-8275. DOI: 10.1523/JNEUROSCI.5855-12.2013
All it takes is an antenna on a headband. If you've got a breathless video report on the dangers of wireless internet connections, that will help your case. It doesn't take much, though, to turn an ominous hint into a real headache.
Some people consider themselves sensitive to electromagnetic fields. They report symptoms such as burning skin, tingling, nausea, dizziness, or chest pain, and they blame their malaise on nearby power lines, cell phones, or WiFi networks. A recent Slate arti........ Read more »
Witthöft, M., & Rubin, G. (2013) Are media warnings about the adverse health effects of modern life self-fulfilling? An experimental study on idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF). Journal of Psychosomatic Research, 74(3), 206-212. DOI: 10.1016/j.jpsychores.2012.12.002
by Liz in Science of Eating Disorders
I have been fascinated and perplexed by reports of the seemingly invigorating and anxiety reducing effects of bingeing and purging (purging by self-induced vomiting). Personally, I cringe at the idea of self-induced vomiting and have always wanted to avoid vomiting at all costs, including during food poisoning. The insight from recent blog entries and the subsequent comments has made an impact on me. I see that the motivation to engage in bingeing/purging (b/p-ing) behavior ........ Read more »
Avena, N., Rada, P., Moise, N., & Hoebel, B. (2006) Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response. Neuroscience, 139(3), 813-820. DOI: 10.1016/j.neuroscience.2005.12.037
Take Home Message: The balance error scoring system (BESS) test is more effective in assessing high school age students’ concussions compared to the Balance Accelerometer Measure (BAM) assessment. The tandem leg stances on firm and foam surface of the BESS test are the most sensitive and specific positions for the detection of a concussion.
Assessing balance after a concussion provides useful information not only for diagnosis and prognosis but also during the athlete’s return to ........ Read more »
Furman GR, Lin CC, Bellanca JL, Marchetti GF, Collins MW, & Whitney SL. (2013) Comparison of the Balance Accelerometer Measure and Balance Error Scoring System in Adolescent Concussions in Sports. The American Journal of Sports Medicine. PMID: 23585486
This Mother’s Day leads me to not only reflect on the fortunes of my own family, but also the misfortunes of other mothers. ... Read more »
Fairley, J., Bisanzio, D., King, C., Kitron, U., Mungai, P., Muchiri, E., King, C., & Malhotra, I. (2012) Birthweight in Offspring of Mothers with High Prevalence of Helminth and Malaria Infection in Coastal Kenya. American Journal of Tropical Medicine and Hygiene, 88(1), 48-53. DOI: 10.4269/ajtmh.2012.12-0371
Seydel LS, Petelski A, van Dam GJ, van der Kleij D, Kruize-Hoeksma YC, Luty AJ, Yazdanbakhsh M, & Kremsner PG. (2012) Association of in utero sensitization to Schistosoma haematobium with enhanced cord blood IgE and increased frequencies of CD5- B cells in African newborns. The American journal of tropical medicine and hygiene, 86(4), 613-9. PMID: 22492145
Nodding syndrome.Ever heard of it? Well, up until a few days ago I hadn't. That is before coming across articles on the topic by Richard Idro and colleagues* (open-access) and Angelina Kakooza-Mwesige and colleagues** (open-access). Whilst not specifically my line of expertise or interest, I was intrigued to read about how nodding and other symptoms of the epileptic variety, at least in some cases, seemed to be precipitated by food and showed a potential nutritional angle.Curving spacetime&........ Read more »
Herbert, M., & Buckley, J. (2013) Autism and Dietary Therapy: Case Report and Review of the Literature. Journal of Child Neurology. DOI: 10.1177/0883073813488668
Medieval alchemists devoted their lives to the pursuit of the infamous Philosopher's Stone, an elusive substance that was thought to convert base metals into valuable gold. Needless to say, nobody ever discovered the Philosopher’s Stone. Well, perhaps some alchemist did get lucky but was wise enough to keep the discovery secret. Instead of publishing the discovery and receiving the Nobel Prize for Alchemy, the lucky alchemist probably just walked around in junkyards, surreptitiously c........ Read more »
Nam, Y., Song, K., Luo, X., Daniel, E., Lambeth, K., West, K., Hill, J., DiMaio, J., Baker, L., Bassel-Duby, R.... (2013) Reprogramming of human fibroblasts toward a cardiac fate. Proceedings of the National Academy of Sciences, 110(14), 5588-5593. DOI: 10.1073/pnas.1301019110
Researchers have found that blood of youngsters can rejuvenate the heart of the old ones - at least in mice.
Previously, researchers found that the blood from the young mice could rejuvenate the brain of the older mice. (Nature, doi:10.1038/nature10357).
In the new study, researchers worked on two mice; one was 2-month-old and the other was 23-month-old having cardiac hypertrophy - a condition in which the heart muscle thickens lead........ Read more »
Loffredo, F., Steinhauser, M., Jay, S., Gannon, J., Pancoast, J., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J.... (2013) Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy. Cell, 153(4), 828-839. DOI: 10.1016/j.cell.2013.04.015
For over a decade, cardiologists have been conducting trials in patients using cells extracted from the bone marrow and infusing them into the blood vessels of the heart in patients who have suffered a heart attack. This type of a procedure is not without risks.... Read more »
Surder, D., Manka, R., Lo Cicero, V., Moccetti, T., Rufibach, K., Soncin, S., Turchetto, L., Radrizzani, M., Astori, G., Schwitter, J.... (2013) Intracoronary Injection of Bone Marrow Derived Mononuclear Cells, Early or Late after Acute Myocardial Infarction: Effects on Global Left Ventricular Function Four months results of the SWISS-AMI trial. Circulation. DOI: 10.1161/CIRCULATIONAHA.112.001035
Rehman, J. (2013) Bone Marrow Tinctures for Cardiovascular Disease: Lost in Translation. Circulation. DOI: 10.1161/CIRCULATIONAHA.113.002775
Right and Left Insula Cortex Highlighted in TealBiomarker research in brain disorders including schizophrenia and mood disorders is an important pathway to early identification and prevention.In a previous post, I reviewed a summary of current biomarker research in schizophrenia. This summary suggested that accelerated brain gray matter volume decline during childhood and adolescence is a candidate biomarker in schizophrenia.In this post, I will look at a similar imaging biomarker study in........ Read more »
Whalley HC, Sussmann JE, Romaniuk L, Stewart T, Papmeyer M, Sprooten E, Hackett S, Hall J, Lawrie SM, & McIntosh AM. (2013) Prediction of depression in individuals at high familial risk of mood disorders using functional magnetic resonance imaging. PloS one, 8(3). PMID: 23483904
"There's no mystical energy field that controls my destiny". So said a very sceptical Han Solo.Regular readers might know that I'm a bit of fan of the whole gut-brain axis; indeed other kinds of axes too. I know that to some it might sound a bit daft that what goes on in our deepest, darkest bowels might actually have some important effects on the operations of the grey-pinkish matter floating around in skull central - and vice-versa - but nonetheless it interests me. The gastrointestinal ........ Read more »
Rogers, M., Greene, M., Young, V., Saint, S., Langa, K., Kao, J., & Aronoff, D. (2013) Depression, antidepressant medications, and risk of Clostridium difficile infection. BMC Medicine, 11(1), 121. DOI: 10.1186/1741-7015-11-121
Take Home Message: The Wii Balance Board is an acceptable substitute for measuring the center of pressure during single leg stance balance tests.
While a laboratory grade force plate is the gold standard for both testing and training balance, these force plates are limited to research laboratories. Due to the importance of balance testing and training during the rehabilitation process, a cost effective, widely available and portable force plate is desirable. Therefore, Huurnink and colleagues........ Read more »
Huurnink A, Fransz DP, Kingma I, & van Dieën JH. (2013) Comparison of a laboratory grade force platform with a Nintendo Wii Balance Board on measurement of postural control in single-leg stance balance tasks. Journal of Biomechanics, 46(7), 1392-5. PMID: 23528845
....public health advocates have called for deworming as a cost-effective strategy to reduce risk of contracting HIV in regions endemic for S. haematobium and HIV... Read more »
Ndeffo Mbah, M., Kjetland, E., Atkins, K., Poolman, E., Orenstein, E., Meyers, L., Townsend, J., & Galvani, A. (2013) Cost-effectiveness of a community-based intervention for reducing the transmission of Schistosoma haematobium and HIV in Africa. Proceedings of the National Academy of Sciences, 110(19), 7952-7957. DOI: 10.1073/pnas.1221396110
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