You can lead a fish to water, but can you make it smoke?
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Yay – another GPCR structure to look at! I just noticed that the 2.9A Dopamine D3 Receptor (in complex with Eticlopride) coordinates 3PBL have been released by the PDB earlier this week. This one will take some time to digest. My congratulations go again to the Stevens lab at TSRI. This is a great achievement, well done.... Read more »
Chien, E., Liu, W., Zhao, Q., Katritch, V., Won Han, G., Hanson, M., Shi, L., Newman, A., Javitch, J., Cherezov, V.... (2010) Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science, 330(6007), 1091-1095. DOI: 10.1126/science.1197410
Congratulations to Ray Stevens and team to determining and publishing the crystallographic structure of the CXCR4 Chemokine receptor in Science. The diffenent binding areas for the small molecule and peptide antagonist are nicely resolved and show extensive interactions with binding pocket residues in the 2.5 – 3.1 A crystal structures... Read more »
Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC.... (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.), 330(6007), 1066-71. PMID: 20929726
A Friday Weird Science guest post on Neurotic Physiology takes a humorous look at anogenital distance and its implication for fertility in adult males.... Read more »
Eisenberg, M., Hsieh, M., Walters, R., Krasnow, R., & Lipshultz, L. (2011) The Relationship between Anogenital Distance, Fatherhood, and Fertility in Adult Men. PLoS ONE, 6(5). DOI: 10.1371/journal.pone.0018973
The paper describes how “in the past most stores were able to sell pseudoephedrine”, the US’s most popular decongestant but new laws require pharmacies, often with restricted opening hours to sell the medicine only to those carrying government issued ID. The paper argues that “it would be of great interest to have a simple synthesis of pseudoephedrine from reagents which can be more readily procured”. The study is published in the splendidly titled Journal of Apocry........ Read more »
Hai, O. Hakkenshit, I.B. (2012) A Simple and Convenient Synthesis of Pseudoephedrine From N-Methylamphetamine. Journal of Apocryphal Chemistry, 213-21. info:/1F.1BC9/b00000F00A
Because I like to understand what I'm putting in my body, I decided to explore coffee: its history, its neurological mechanism, and—what I'm sure everyone's dying to know—why it is so easy to become addicted and dependent on it.... Read more »
Cocker PJ, Hosking JG, Benoit J, & Winstanley CA. (2012) Sensitivity to Cognitive Effort Mediates Psychostimulant Effects on a Novel Rodent Cost/Benefit Decision-Making Task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. PMID: 22453140
Don’t give it any more thought: according to scientists, left side of the face usually looks better, mainly because it’s more expressive than the right side. Researchers at the Wake Forest University showed a series of photographs to 37 people, some of them mirror-reversed, so the viewers wouldn’t know which side they were looking at. In most cases, they chose the left side no matter where it was in the picture.... Read more »
Blackburn, K., & Schirillo, J. (2012) Emotive hemispheric differences measured in real-life portraits using pupil diameter and subjective aesthetic preferences. Experimental Brain Research. DOI: 10.1007/s00221-012-3091-y
Recent psilocybin research has found that not only does personality influence response to the drug, but that the drug can produce long-term changes in features of personality relating to openness to experience. The relationship between personality and psilocybin seems to be two-way. Future research may illuminate the shared basis of mystical-type experiences and related features of personality.... Read more »
MacLean, K. A., Johnson, M. W., . (2011) Mystical Experiences Occasioned by the Hallucinogen Psilocybin Lead to Increases in the Personality Domain of Openness. Journal of Psychopharmacology, 25(11), 1453-1461. DOI: 10.1177/0269881111420188
Studerus E, Gamma A, Kometer M, & Vollenweider FX. (2012) Prediction of psilocybin response in healthy volunteers. PloS one, 7(2). PMID: 22363492
What is harder to resist? Checking your Twitter or Facebook account at work or eating a delicious, but fattening snack when you try to watch your calories? Both are inner conflicts, best described as 'I really want to do this, but I should not'.
This blog post looks at the paper of Wilhelm Hofmann, Kathlees Vohs and Roy Baummeister who recently tried to answer these questions in their Everyday Temptation Study. ... Read more »
Hofmann W, Baumeister RF, Förster G, & Vohs KD. (2012) Everyday temptations: an experience sampling study of desire, conflict, and self-control. Journal of personality and social psychology, 102(6), 1318-35. PMID: 22149456
Description of new Science Translational Medicine pub out of Johns Hopkins. Epigenetic profiling of metastatic prostate cancer reveals that epigenetic biomarkers are worth the search.... Read more »
Aryee MJ, Liu W, Engelmann JC, Nuhn P, Gurel M, Haffner MC, Esopi D, Irizarry RA, Getzenberg RH, Nelson WG.... (2013) DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Science translational medicine, 5(169). PMID: 23345608
A couple of years ago, I read Kary Mullis’s autobiography "Dancing Naked in the Mind Field" , and it shaped my life in some aspects. Kary, with his eccentric mood, shows that as one of the major properties required by the new notion "disruptive innovation", intuitive minds are gradually becoming the leading power of intelligence revolution. People who manage to ace merely the exams are predictably swept out.
In my first year as an undergraduate student, I was surroun........ Read more »
That is the recipe for depression. Chronic Mild Stress (CMS). Or at least it is the recipe I used to depress rats. As I mentioned earlier I worked with rats to research the mood-effects of Salvia. One important piece of this research was the idea that a depressed brain is different than a healthy brain and may respond differently to drug exposure. So in order to apply that in rats, I needed a way to create depressed rats. For me, that meant using CMS.
... Read more »
Katz, R. (1982) Animal model of depression: Pharmacological sensitivity of a hedonic deficit. Pharmacology Biochemistry and Behavior, 16(6), 965-968. DOI: 10.1016/0091-3057(82)90053-3
Willner, P. (2005) Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS. Neuropsychobiology, 52(2), 90-110. DOI: 10.1159/000087097
Male spiders can be missing their organs (pedipalps) and this is clearly quite a cost for their fitness! This post explores this topic, with some original data, and with some discussion of past literature on the topic.... Read more »
Buddle, C. (2001) Spiders (Araneae) associated with downed woody material in a deciduous forest in central Alberta, Canada. Agricultural and Forest Entomology, 3(4), 241-251. DOI: 10.1046/j.1461-9555.2001.00103.x
Buddle, C., Spence, J., & Langor, D. (2000) Succession of boreal forest spider assemblages following wildfire and harvesting. Ecography, 23(4), 424-436. DOI: 10.1034/j.1600-0587.2000.230405.x
Knoflach, B., & van Harten, A. (2001) Tidarren argo sp. nov. (Araneae: Theridiidae) and its exceptional copulatory behaviour: emasculation, male palpal organ as a mating plug and sexual cannibalism. Journal of Zoology, 254(4), 449-459. DOI: 10.1017/S0952836901000954
Lynam, E., Owens, J., & Persons, M. (2006) The Influence of Pedipalp Autotomy on the Courtship and Mating Behavior of Pardosa milvina (Araneae: Lycosidae). Journal of Insect Behavior, 19(1), 63-75. DOI: 10.1007/s10905-005-9008-x
Ramos, M. (2004) Overcoming an evolutionary conflict: Removal of a reproductive organ greatly increases locomotor performance. Proceedings of the National Academy of Sciences, 101(14), 4883-4887. DOI: 10.1073/pnas.0400324101
A new solar cell using a lead halide perovskite absorber provides efficiency rivaling thin film photovoltaics due to ultrafast carrier extraction.... Read more »
Arianna Marchioro, Joël Teuscher, Dennis Friedrich, Marinus Kunst, Roel van de Krol, Thomas Moehl, Michael Grätzel . (2014) Unravelling the mechanism of photoinduced charge transfer processes in lead iodide perovskite solar cells. Nature Photonics. DOI: 10.1038/nphoton.2013.374
New study on fruit flies suggests general anesthetics can affect electron-spin properties... Read more »
Turin Luca, Skoulakis Efthimios, & Horsfield Andrew. (2014) Electron spin changes during general anesthesia in Drosophila. PNAS, Early edition(N/A). DOI: 10.1073/pnas.1404387111
A loot at two studies that investigate the effectiveness of activity trackers.... Read more »
Diaz K, Krupka D, Chang M, Peacock J, Ma Y, Goldsmith J, Schwartz J, & Davidson K. (2015) Fitbit®: An accurate and reliable device for wireless physical activity tracking. International Journal of Cardiology, 138-140. DOI: 10.1016/j.ijcard.2015.03.038
Ferguson T, Rowlands A, Olds T, & Maher C. (2015) The validity of consumer-level, activity monitors in healthy adults worn in free-living conditions: a cross-sectional study. International Journal of Behavioral Nutrition and Physical Activity, 12(1). DOI: 10.1186/s12966-015-0201-9
Cities are getting more complex. As they grow, their transportation systems become increasingly large and multimodal. Could those human-constructed environments exceed our cognitive capacity?... Read more »
Gallotti, R., Porter, M., & Barthelemy, M. (2016) Lost in transportation: Information measures and cognitive limits in multilayer navigation. Science Advances, 2(2). DOI: 10.1126/sciadv.1500445
A Harvard University team of researchers with expertise in various fields recently came together to develop the first entirely soft robots. ... Read more »
Wehner M, Truby RL, Fitzgerald DJ, Mosadegh B, Whitesides GM, Lewis JA, & Wood RJ. (2016) An integrated design and fabrication strategy for entirely soft, autonomous robots. Nature, 536(7617), 451-5. PMID: 27558065
The germline FLCN missense mutations H255Y (Hasumi et al., 2009) and K508R (Toro et al., 2008) have been identified in patients with bilateral multifocal (BMF) kidney tumours and other clinical symptoms of Birt-Hogg-Dube (BHD) syndrome, or with BMF kidney tumours as the only manifestation. Building on their previous work identifying the H255Y mutation in human BHD kidney tumour, Hasumi et al. (2016) investigated whether these mutations have an impact on FLCN function. The authors evaluated the F........ Read more »
Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Lang M, Irie N, Esumi C, Merino MJ.... (2016) H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation. Human molecular genetics. PMID: 28007907
During the current Zika Virus (ZIKV) outbreaks in the Americas, an increased number of cognitive malformations including but not limited to microcephaly in foetuses and neonates of mothers who had been infected with ZIKV during pregnancy, lead to the conclusion that ZIKV might be neuroteratogenic, a hypothesis that has been supported by findings that various ZIKV strains –including isolates from Asia such ZIKV SZ 01, ZIKV FSS13025 and H/PF/2013 as well as isolates from the Americas such a........ Read more »
van den Pol AN, Mao G, Yang Y, Ornaghi S, & Davis JN. (2017) Zika virus targeting in the developing brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. PMID: 28123079
Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell, 19(5), 593-598. PMID: 27545505
Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870
Garcez PP, Nascimento JM, de Vasconcelos JM, Madeiro da Costa R, Delvecchio R, Trindade P, Loiola EC, Higa LM, Cassoli JS, Vitória G.... (2017) Zika virus disrupts molecular fingerprinting of human neurospheres. Scientific reports, 40780. PMID: 28112162
Gabriel, E., Ramani, A., Karow, U., Gottardo, M., Natarajan, K., Gooi, L., Goranci-Buzhala, G., Krut, O., Peters, F., Nikolic, M.... (2017) Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell. DOI: 10.1016/j.stem.2016.12.005
Ghouzzi VE, Bianchi FT, Molineris I, Mounce BC, Berto GE, Rak M, Lebon S, Aubry L, Tocco C, Gai M.... (2017) ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53. Cell death , 8(1). PMID: 28102842
Caldon CE, & Musgrove EA. (2010) Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer. Cell division, 2. PMID: 20180967
Gromley A, Jurczyk A, Sillibourne J, Halilovic E, Mogensen M, Groisman I, Blomberg M, & Doxsey S. (2003) A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. The Journal of cell biology, 161(3), 535-45. PMID: 12732615
Shimada M, Matsuzaki F, Kato A, Kobayashi J, Matsumoto T, & Komatsu K. (2016) Induction of Excess Centrosomes in Neural Progenitor Cells during the Development of Radiation-Induced Microcephaly. PloS one, 11(7). PMID: 27367050
Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK.... (2016) 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. The Journal of cell biology, 214(2), 155-66. PMID: 27432897
Liu H, Gong M, French BA, Liao G, Li J, Tillman B, & French SW. (2015) Aberrant modulation of the BRCA1 and G1/S cell cycle pathways in alcoholic hepatitis patients with Mallory Denk Bodies revealed by RNA sequencing. Oncotarget, 6(40), 42491-503. PMID: 26623723
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