Post List

  • November 30, 1999
  • 12:00 AM
  • 3,248 views

Nicotine and the Humphrey Bogart Gene

by Dirk Hanson in Addiction Inbox

You can lead a fish to water, but can you make it smoke?

... Read more »

Petzold AM, Balciunas D, Sivasubbu S, Clark KJ, Bedell VM, Westcot SE, Myers SR, Moulder GL, Thomas MJ, & Ekker SC. (2009) Nicotine response genetics in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 106(44), 18662-7. PMID: 19858493  

  • November 30, 1999
  • 12:00 AM
  • 2,473 views

New GPCR Structure: Dopamine D3 Receptor

by Peter Nollert in Protein Crystallization Blog

Yay – another GPCR structure to look at! I just noticed that the 2.9A Dopamine D3 Receptor (in complex with Eticlopride) coordinates 3PBL have been released by the PDB earlier this week. This one will take some time to digest. My congratulations go again to the Stevens lab at TSRI. This is a great achievement, well done.... Read more »

Chien, E., Liu, W., Zhao, Q., Katritch, V., Won Han, G., Hanson, M., Shi, L., Newman, A., Javitch, J., Cherezov, V.... (2010) Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science, 330(6007), 1091-1095. DOI: 10.1126/science.1197410  

  • November 30, 1999
  • 12:00 AM
  • 2,373 views

New GPCR structure: CXCR4 Chemokine Receptor (HIV and cancer target)

by Peter Nollert in Emerald BioStructures Blog

Congratulations to Ray Stevens and team to determining and publishing the crystallographic structure of the CXCR4 Chemokine receptor in Science. The diffenent binding areas for the small molecule and peptide antagonist are nicely resolved and show extensive interactions with binding pocket residues in the 2.5 – 3.1 A crystal structures... Read more »

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC.... (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.), 330(6007), 1066-71. PMID: 20929726  

  • November 30, 1999
  • 12:00 AM
  • 2,984 views

Friday Weird Science GUEST POST: The distance between your testicles and your anus, 'taint unimportant

by Allie Wilkinson in OH, FOR THE LOVE OF SCIENCE!

A Friday Weird Science guest post on Neurotic Physiology takes a humorous look at anogenital distance and its implication for fertility in adult males.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,194 views

Synthesising Pseudoephedrine From N-Methylamphetamine

by Neurobonkers in Neurobonkers

The paper describes how “in the past most stores were able to sell pseudoephedrine”, the US’s most popular decongestant but new laws require pharmacies, often with restricted opening hours to sell the medicine only to those carrying government issued ID. The paper argues that “it would be of great interest to have a simple synthesis of pseudoephedrine from reagents which can be more readily procured”. The study is published in the splendidly titled Journal of Apocry........ Read more »

Hai, O. Hakkenshit, I.B. (2012) A Simple and Convenient Synthesis of Pseudoephedrine From N-Methylamphetamine. Journal of Apocryphal Chemistry, 213-21. info:/1F.1BC9/b00000F00A

  • November 30, 1999
  • 12:00 AM
  • 2,677 views

Coffee: a caffeinated chronicle

by Jordan Gaines in Gaines, on Brains

Because I like to understand what I'm putting in my body, I decided to explore coffee: its history, its neurological mechanism, and—what I'm sure everyone's dying to know—why it is so easy to become addicted and dependent on it.... Read more »

Cocker PJ, Hosking JG, Benoit J, & Winstanley CA. (2012) Sensitivity to Cognitive Effort Mediates Psychostimulant Effects on a Novel Rodent Cost/Benefit Decision-Making Task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. PMID: 22453140  

  • November 30, 1999
  • 12:00 AM
  • 1,722 views

Your Good Side Is the Left Side, According to Science

by United Academics in United Academics

Don’t give it any more thought: according to scientists, left side of the face usually looks better, mainly because it’s more expressive than the right side. Researchers at the Wake Forest University showed a series of photographs to 37 people, some of them mirror-reversed, so the viewers wouldn’t know which side they were looking at. In most cases, they chose the left side no matter where it was in the picture.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,200 views

Psilocybin and personality

by Scott McGreal in Eye on Psych

Recent psilocybin research has found that not only does personality influence response to the drug, but that the drug can produce long-term changes in features of personality relating to openness to experience. The relationship between personality and psilocybin seems to be two-way. Future research may illuminate the shared basis of mystical-type experiences and related features of personality.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,927 views

3 surprising insights on how food cravings relate to other desires in everyday life

by Ellen van Kleef in Food Intake Control

What is harder to resist? Checking your Twitter or Facebook account at work or eating a delicious, but fattening snack when you try to watch your calories? Both are inner conflicts, best described as 'I really want to do this, but I should not'.

This blog post looks at the paper of Wilhelm Hofmann, Kathlees Vohs and Roy Baummeister who recently tried to answer these questions in their Everyday Temptation Study. ... Read more »

Hofmann W, Baumeister RF, Förster G, & Vohs KD. (2012) Everyday temptations: an experience sampling study of desire, conflict, and self-control. Journal of personality and social psychology, 102(6), 1318-35. PMID: 22149456  

  • November 30, 1999
  • 12:00 AM
  • 1,258 views

Methylomes in Lethal Prostate Cancer Support Personalized Medicine

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

Description of new Science Translational Medicine pub out of Johns Hopkins. Epigenetic profiling of metastatic prostate cancer reveals that epigenetic biomarkers are worth the search.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,391 views

About connecting the dots

by Eugenio Maria Battaglia in Science to Grok

A couple of years ago, I read Kary Mullis’s autobiography "Dancing Naked in the Mind Field" , and it shaped my life in some aspects. Kary, with his eccentric mood, shows that as one of the major properties required by the new notion "disruptive innovation", intuitive minds are gradually becoming the leading power of intelligence revolution. People who manage to ace merely the exams are predictably swept out.

In my first year as an undergraduate student, I was surroun........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,631 views

a little bit of unpredictable stress everyday

by Mitchell Harden in Mitch's Blog

That is the recipe for depression. Chronic Mild Stress (CMS). Or at least it is the recipe I used to depress rats. As I mentioned earlier I worked with rats to research the mood-effects of Salvia. One important piece of this research was the idea that a depressed brain is different than a healthy brain and may respond differently to drug exposure. So in order to apply that in rats, I needed a way to create depressed rats. For me, that meant using CMS.
... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,380 views

The case of the missing genitalia: copulation costs for male spiders

by Chris Buddle in Arthropod Ecology

Male spiders can be missing their organs (pedipalps) and this is clearly quite a cost for their fitness! This post explores this topic, with some original data, and with some discussion of past literature on the topic.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,935 views

New solar architecture provides efficiency competitive with thin film photovoltaics

by Jonathan Trinastic in Goodnight Earth

A new solar cell using a lead halide perovskite absorber provides efficiency rivaling thin film photovoltaics due to ultrafast carrier extraction.... Read more »

Arianna Marchioro, Joël Teuscher, Dennis Friedrich, Marinus Kunst, Roel van de Krol, Thomas Moehl, Michael Grätzel . (2014) Unravelling the mechanism of photoinduced charge transfer processes in lead iodide perovskite solar cells. Nature Photonics. DOI: 10.1038/nphoton.2013.374  

  • November 30, 1999
  • 12:00 AM
  • 1,716 views

Electron-spin clue to solving general anesthesia mystery

by This Science is Crazy! in This Science Is Crazy!

New study on fruit flies suggests general anesthetics can affect electron-spin properties... Read more »

Turin Luca, Skoulakis Efthimios, & Horsfield Andrew. (2014) Electron spin changes during general anesthesia in Drosophila. PNAS, Early edition(N/A). DOI: 10.1073/pnas.1404387111  

  • November 30, 1999
  • 12:00 AM
  • 1,063 views

Is Your Tech Working for You? Accuracy of Activity Trackers

by Rodney Steadman in Gravity's Pull

A loot at two studies that investigate the effectiveness of activity trackers.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,030 views

Lost in Transportation

by Paco Jariego in Mind the Post

Cities are getting more complex. As they grow, their transportation systems become increasingly large and multimodal. Could those human-constructed environments exceed our cognitive capacity?... Read more »

  • November 30, 1999
  • 12:00 AM
  • 742 views

Autonomous, soft robots

by vitul in Think, Ask and Resolve

A Harvard University team of researchers with expertise in various fields recently came together to develop the first entirely soft robots. ... Read more »

Wehner M, Truby RL, Fitzgerald DJ, Mosadegh B, Whitesides GM, Lewis JA, & Wood RJ. (2016) An integrated design and fabrication strategy for entirely soft, autonomous robots. Nature, 536(7617), 451-5. PMID: 27558065  

  • November 30, 1999
  • 12:00 AM
  • 366 views

H255Y and K508R missense mutations in FLCN promote kidney neoplasia

by Joana Guedes in BHD Research Blog

The germline FLCN missense mutations H255Y (Hasumi et al., 2009) and K508R (Toro et al., 2008) have been identified in patients with bilateral multifocal (BMF) kidney tumours and other clinical symptoms of Birt-Hogg-Dube (BHD) syndrome, or with BMF kidney tumours as the only manifestation. Building on their previous work identifying the H255Y mutation in human BHD kidney tumour, Hasumi et al. (2016) investigated whether these mutations have an impact on FLCN function. The authors evaluated the F........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 409 views

Impairment of neurogenesis in ZIKV infected neuronal cells: strain specific ? Asian/American v. African strains

by thelonevirologist in Virology Tidbits

During the current Zika Virus (ZIKV) outbreaks in the Americas, an increased number of cognitive malformations including but not limited to microcephaly in foetuses and neonates of mothers who had been infected with ZIKV during pregnancy, lead to the conclusion that ZIKV might be neuroteratogenic, a hypothesis that has been supported by findings that various ZIKV strains –including isolates from Asia such ZIKV SZ 01, ZIKV FSS13025 and H/PF/2013 as well as isolates from the Americas such a........ Read more »

Li H, Saucedo-Cuevas L, Shresta S, & Gleeson JG. (2016) The Neurobiology of Zika Virus. Neuron, 92(5), 949-958. PMID: 27930910  

van den Pol AN, Mao G, Yang Y, Ornaghi S, & Davis JN. (2017) Zika virus targeting in the developing brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. PMID: 28123079  

Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell, 19(5), 593-598. PMID: 27545505  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Garcez PP, Nascimento JM, de Vasconcelos JM, Madeiro da Costa R, Delvecchio R, Trindade P, Loiola EC, Higa LM, Cassoli JS, Vitória G.... (2017) Zika virus disrupts molecular fingerprinting of human neurospheres. Scientific reports, 40780. PMID: 28112162  

Gabriel, E., Ramani, A., Karow, U., Gottardo, M., Natarajan, K., Gooi, L., Goranci-Buzhala, G., Krut, O., Peters, F., Nikolic, M.... (2017) Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell. DOI: 10.1016/j.stem.2016.12.005  

Gromley A, Jurczyk A, Sillibourne J, Halilovic E, Mogensen M, Groisman I, Blomberg M, & Doxsey S. (2003) A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. The Journal of cell biology, 161(3), 535-45. PMID: 12732615  

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK.... (2016) 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. The Journal of cell biology, 214(2), 155-66. PMID: 27432897  

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