Over the last few weeks I've received quite a few questions relating to castration resistance and how it happens. After all, while we have several therapies now approved once androgen deprivation therapy (ADT) fails, if we could keep men hormone...... Read more »
Yamaoka M, Hara T, & Kusaka M. (2010) Overcoming persistent dependency on androgen signaling after progression to castration-resistant prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 16(17), 4319-24. PMID: 20647476
Harris, William P, Mostaghel, Elahe A, Nelson, Peter S, & Montgomery, Bruce. (2009) Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. nature clinical practice UROLOGY, 6(2), 76-85. DOI: 10.1038/ncpuro1296
Tomlins, SA, Rhodes, DR, & Perner, S. (2005) Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science, 644-648. DOI: 10.1126/science.1117679
Wandering through the grocery store the other day, I noticed something strange in the fish bin. Now, in general I’m pretty conscious of where my fish comes from, how it was caught, whether the fishery as a whole or the specific population is sustainable. I pay attention to those details and I can usually tell [...]... Read more »
Clark, M. (2001) Are deepwater fisheries sustainable? — the example of orange roughy (Hoplostethus atlanticus) in New Zealand. Fisheries Research, 51(2-3), 123-135. DOI: 10.1016/S0165-7836(01)00240-5
by Travis Saunders, MSc, CEP in Obesity Panacea
http://www.flickr.com/photos/abbynormy/ / CC BY 2.0
Earlier this year, Peter wrote a post about Wii-related injuries which generated some interesting discussion. Essentially, some readers felt that we were being too hard on the Wii, with one commenter going so far as to suggest that the post was “anti-Wii” (hard to dispute, given that the post was focused on Wii-related injuries!). Although we’ve mentioned the Wii in passing on Obesity Panacea before, we’ve never ........ Read more »
Graves, L., Stratton, G., Ridgers, N., & Cable, N. (2007) Comparison of energy expenditure in adolescents when playing new generation and sedentary computer games: cross sectional study. BMJ, 335(7633), 1282-1284. DOI: 10.1136/bmj.39415.632951.80
Daley, A. (2009) Can Exergaming Contribute to Improving Physical Activity Levels and Health Outcomes in Children?. PEDIATRICS, 124(2), 763-771. DOI: 10.1542/peds.2008-2357
I hope everyone has been enjoying my write-ups of Inside Nature's Giants (ING), series 2 (for comments on episode 1 go here, and for thoughts on episode 2 go here). Time to look at ep 3: the big cat one.
Given that big cats are more popular (among the general populace) than are either sharks or snakes, it's predictable that this was the most discussed, most anticipated episode. Like the others, it was excellent [adjacent image © Windfall Films/Channel 4].
And let me say again how good th........ Read more »
The prevalence of autism spectrum disorders (ASDs) has increased by nearly 10-fold in the last 2 decades, owing, in part, to earlier diagnosis by community practitioners. Now, a new study in the September 2010 issue of Pediatrics reports that signs of autism may be present as early as 1 month of age. Researchers evaluated children [...]... Read more »
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2006 Principal Investigators, & Centers for Disease Control and Prevention (CDC). (2009) Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, United States, 2006. MMWR. Surveillance summaries : Morbidity and mortality weekly report. Surveillance summaries / CDC, 58(10), 1-20. PMID: 20023608
Karmel BZ, Gardner JM, Meade LS, Cohen IL, London E, Flory MJ, Lennon EM, Miroshnichenko I, Rabinowitz S, Parab S.... (2010) Early Medical and Behavioral Characteristics of NICU Infants Later Classified With ASD. Pediatrics, 126(3), 457-67. PMID: 20679296
Stoltenberg C, Schjølberg S, Bresnahan M, Hornig M, Hirtz D, Dahl C, Lie KK, Reichborn-Kjennerud T, Schreuder P, Alsaker E.... (2010) The Autism Birth Cohort: a paradigm for gene-environment-timing research. Molecular psychiatry, 15(7), 676-80. PMID: 20571529
Vandenberg KA. (2007) Individualized developmental care for high risk newborns in the NICU: a practice guideline. Early human development, 83(7), 433-42. PMID: 17467932
Italian researchers reviewed the medical/nutrition literature of the last three years and confirmed that the Mediterranean diet 1) reduces the risk of death, 2) reduces heart disease illness and death, 3) cuts the risk of getting or dying from cancer, and 4) diminishes the odds of developing dementia, Parkinsons disease, stroke, and mild cognitive impairment.
These same [...]... Read more »
Sofi F, Abbate R, Gensini GF, & Casini A. (2010) Accruing evidence about benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. The American journal of clinical nutrition. PMID: 20810976
Good news for sheep: scientists have moved a step closer to understanding how a disease-causing worm evades the sheep immune system. Parasitic gastroenteritis (PGE) causes diarrhoea, weight loss and dehydration in sheep and can be fatal. The disease is commonly caused by a nematode worm, Teladorsagia circumcincta, which makes its home in the stomach of [...]... Read more »
Nisbet AJ, Bell NE, McNeilly TN, Knox DP, Maizels RM, Meikle LI, Wildblood LA, Matthews JB. (2010) A macrophage migration inhibitory factor-like tautomerase from Teladorsagia circumcincta (Nematoda: Strongylida). Parasite Immunol., 32(7), 503-511. DOI: 10.1111/j.1365-3024.2010.01215.x
The sea is a dark and often mysterious place, and it's no wonder that the fear and fascination with the marine world has led to more than a few inaccurate claims. The crew over at Southern Fried Science have decided that this week is all about busting pseudoscience and the myths that surround our ocean realm. As it turns out, I'd posted about one of these before. So here, in honor of Ocean of Pseudoscience week, is a repost busting the myth that sharks don't get cancer.
There are a lot of myths........ Read more »
Brem H, & Folkman J. (1975) Inhibition of tumor angiogenesis mediated by cartilage. . J Exp Med, 427-439. DOI: 10.1084/jem.141.2.427
Langer R, & et al. (1976) Isolations of a cartilage factor that inhibits tumor neovascularization. Science, 70-72. DOI: 10.1126/science.935859
Lee A, & Langer R. (1983) Shark cartilage contains inhibitors of tumor angiogenesis. Science, 1185-1187. DOI: 10.1126/science.6193581
Luer CA, & Luer WH. (1982) Acute and chronic exposure of nurse sharks to aflatoxin B1. Federal Proceedings, 925. info:/
Horsman MR, Alsner J, & Overgaard J. (1998) The effect of shark cartilage extracts on the growth and metastatic spread of the SCCVII carcinoma. Acta oncologica (Stockholm, Sweden), 37(5), 441-5. PMID: 9831372
Miller DR, Anderson GT, Stark JJ, Granick JL, & Richardson D. (1998) Phase I/II trial of the safety and efficacy of shark cartilage in the treatment of advanced cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 16(11), 3649-55. PMID: 9817287
Loprinzi CL, Levitt R, Barton DL, Sloan JA, Atherton PJ, Smith DJ, Dakhil SR, Moore DF Jr, Krook JE, Rowland KM Jr.... (2005) Evaluation of shark cartilage in patients with advanced cancer: a North Central Cancer Treatment Group trial. Cancer, 104(1), 176-82. PMID: 15912493
Lu C, Lee JJ, Komaki R, Herbst RS, Feng L, Evans WK, Choy H, Desjardins P, Esparaz BT, Truong MT.... (2010) Chemoradiotherapy with or without AE-941 in stage III non-small cell lung cancer: a randomized phase III trial. Journal of the National Cancer Institute, 102(12), 859-65. PMID: 20505152
Vickers, A. (2004) Alternative cancer cures: "unproven" or "disproven"?. CA: A Cancer Journal For Clinicians, 110-118. DOI: 10.3322/canjclin.54.2.110
Ostrander GK, Cheng KC, Wolf JC, & Wolfe MJ. (2004) Shark cartilage, cancer and the growing threat of pseudoscience. Cancer research, 64(23), 8485-91. PMID: 15574750
Last week I attended Medical Grand Rounds at the University of Alberta Hospital presented by our Faculty’s latest recruit Sangita Sharma (no relation), Professor in Aboriginal and Global Health and newly Endowed Chair in Aboriginal Health.
Sangita, who earned her PhD in nutritional epidemiology from the University of Manchester, UK, comes to Edmonton from the Nutrition [...]... Read more »
Gittelsohn J, Roache C, Kratzmann M, Reid R, Ogina J, & Sharma S. (2010) Participatory research for chronic disease prevention in Inuit communities. American journal of health behavior, 34(4), 453-64. PMID: 20218757
This post is a scholarly addendum to today’s main post, aimed to satisfy the curiosity of my academic readers. I’m going to leave you with an excerpt from an excellent book chapter, “Repetition and Reuse in Child Language Learning,” by Colin Bannard and Elena Lieven. The two take up the question of why Zipfian distributions [...]... Read more »
Ferrer-i-Cancho, R., & Sole, R. V. (2003) Least effort and the origins of scaling in human language. Proceedings of the National Academy of Sciences of the United States of America, 788-791. DOI: 10.1073/pnas.0335980100
Biemann, C. (2007) A Random Text Model for the Generation of Statistical Language Invariants. Proceedings of HLT-NAACL-07, Rochester, NY, USA. info:/
This morning, I scrawled a letter to a friend that began with the following: Spent the weekend at the FyeahFest with a starry-eyed lot of starving hipsters, in vintage hops and wingtips. Had not realized how obvious the effects of doing molly are on the pupils… the droves wandering past had eyes like shining saucers. [...]... Read more »
KW Church,, & WA Gale. (1995) Inverse document frequency (IDF): A measure of deviations from Poisson. In A. et al. (Ed.), NLP using Very Large Corpora. Kluwer Academic Publishers. . info:/
DeLong, K., Urbach, T., & Kutas, M. (2005) Probabilistic word pre-activation during language comprehension inferred from electrical brain activity. Nature Neuroscience, 8(8), 1117-1121. DOI: 10.1038/nn1504
Do you have medical students rotating in your Emergency Department? Are they allowed to document in the medical record?Charting in the medical record is the cornerstone of clinical communication. You document your findings, your clinical reasoning, and management plan. The medical record allows communication amongst providers. Chart documentation is a crucial skill that every medical student should know, as stated by the Association of American Medical Colleges (AAMC). However, there is a growin........ Read more »
Friedman E, Sainte M, & Fallar R. (2010) Taking note of the perceived value and impact of medical student chart documentation on education and patient care. Academic medicine : journal of the Association of American Medical Colleges, 85(9), 1440-4. PMID: 20736671
If something's troubling you, write it down, put it an envelope and seal it. Doing so will help bring you psychological closure. Xiuping Li at NUS Business School asked 80 students to write about a recent decision they regretted. Half of them were then told to seal their written recollection in an envelope. Afterwards, the envelope students felt less negative about the event than control students who just handed in their recollection without an envelope. The finding was replicated with forty fem........ Read more »
Li X, Wei L, & Soman D. (2010) Sealing the emotions genie: the effects of physical enclosure on psychological closure. Psychological science : a journal of the American Psychological Society / APS, 21(8), 1047-50. PMID: 20622143
What is palliative care? Until quite recently, it's something I haven't given much thought. Although there was a highly regarded article on hospice and palliative care by Atul Gawande in last month's New Yorker, I didn't read it or think it applied to my life. All that changed less than two weeks ago, when my father was hospitalized in critical condition after collapsing. First he went to the ER, then the transitional ICU, and finally he was placed in the palliative care unit by the time I arriv........ Read more »
J.S. Temel et al. (2010) Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer. N Engl J Med, 733-742. info:/10.1056/NEJMoa1000678
Even the most obtuse, right-wing, head-in-the-sand, consumption-driven, anti-environment yob would at least admit that they’ve heard of forest conservation, the plight of whales (more on that little waste of conservation resources later) and climate change. Whether or not they believe these issues are important (or even occurring) is beside the point – the fact that [...]... Read more »
M.L. Thieme, B. Lehner, R. Abell, & J. Matthews. (2010) Exposure of Africa's freshwater biodiversity to a changing climate. Conservation Letters. DOI: 10.1111/j.1755-263X.2010.00120.x
I’m having a problem. I’m an editor for the Dutch/Flemish Journal of Psychiatry. Since I’m a blogger and on twitter and using many more web 2.0 tools I’m supposed to be the expert on web 2.0 and our journal. We’ve revamped our website and the journal is even on twitter. We’re planning presence on Facebook [...]
Related posts:Editing Medical Journals, A Course in Oxford
Twitter, Doctors, Hospitals and Medical Education
Social Media in Health and Medicine: Me........ Read more »
Senoaji Wijaya, Marco Spruit, Wim Scheper, & Johan Versendaal. (2010) Web 2.0-based webstrategies for three different types of organizations. Computers in Human Behavior. info:/10.1016/j.chb.2010.07.041
One noteworthy thing about George Pepper’s interpretations of the effigy vessels found at Pueblo Bonito is his attempt to link them to specific Hopi kachinas. He does find a general similarity in facial and body decoration between one of the partial vessels, found in Room 38, and one kachina and notes at the end of [...]... Read more »
Lekson, S., & Cameron, C. (1995) The abandonment of Chaco Canyon, the Mesa Verde migrations, and the reorganization of the Pueblo world. Journal of Anthropological Archaeology, 184-202. DOI: 10.1006/jaar.1995.1010
I love the Groth and Gurney paper, and not just because it introduced me to http://researchblogging.org/. The authors analyzed 295 blog posts about chemistry and the included citations. In comparison to the usual pieces which deal with science blogging in the scholarly literature, this paper has dealt with a large number of posts. Most of what I've read about science blogging are either opinion articles (Batts et al, 2008), or qualitative research, aka interviews with a small number of bloggers ........ Read more »
Paul Groth, & Thomas Gurney. (2010) Studying Scientific Discourse on the Web Using Bibliometrics: A Chemistry Blogging Case Study. In press. info:/
Sara Kjellberg. (2010) I am a blogging researcher: Motivations for blogging in a scholarly context. First Monday, 15(8). info:other/
Batts, S. A., Anthis, N. J. , & Smith, T. C. (2008) Advancing Science through Conversations: Bridging the Gap between Blogs and the Academy. PLoS Biology, 6(9). DOI: 10.1371/journal.pbio.0060240
Today I would like to introduce a theory developed by Giddens in 1988 about social structures and how it can be used to analyze theories in Supply Chain Management.
Continue reading "Theory about Social Structures"
... Read more »
Pfohl, Hans-Christian, Elbert, Ralf, & Gallus, Philipp. (2007) Implementierung interorganisationaler Managementinstrumente in logistischen Netzwerken: Strukturationstheoretische Analyse der Besonderheiten bei der Implementierung der CargoScoreCard im Kombinierten Verkehr. Logistikmanagement: Analyse, Bewertung und Gestaltung logistischer Systeme, 231-262. info:/
Now, five years later, there's new evidence of the significant, negative impact of Hurricane Katrina on children's mental health. The study "Children as Bellwethers of Recovery" was conducted by researchers from the National Center for Disaster Preparedness at Columbia University's Mailman School of Public Health and was published online by the Journal of Disaster Medicine and Public Health Preparedness.
The results come from a longitudinal study of 1079 families in Louisiana and Mississippi ........ Read more »
Abramson, D. M., Park, Y. S., Stehling-Ariza, T., & Redlener, I. (2010) Children as Bellwethers of Recovery. Disaster Medicine and Public Health Preparedness. info:/10.1001/dmp.2010.7
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