Post List

  • April 24, 2017
  • 04:22 AM
  • 13 views

Promising mouse model for Ngly1 deficiency

by adam phillips in It Ain't Magic

A recent study of Ngly1 deficient mice used a secondary knockout to create double knockouts with symptoms similar to human NGLY1 deficiency.... Read more »

  • April 24, 2017
  • 03:05 AM
  • 15 views

Sensory issues in adult ADHD controlling for autistic symptoms...

by Paul Whiteley in Questioning Answers

I was intrigued to read the paper by Bijlenga and colleagues [1] reporting on "the prevalence of sensory hyper- and hyposensitivity among adults with ADHD [attention-deficit hyperactivity disorder], controlling for autistic symptoms."The authors concluded that among their cohort of over 100 adults diagnosed with ADHD, both sensory hyper- and hyposensitivity symptoms as described by response to the Adolescent/Adult Sensory Profile-NL (AASP-NL), were over-represented compared w........ Read more »

Bijlenga D, Tjon-Ka-Jie JY, Schuijers F, & Kooij JJ. (2017) Atypical sensory profiles as core features of adult ADHD, irrespective of autistic symptoms. European psychiatry : the journal of the Association of European Psychiatrists, 51-57. PMID: 28371743  

  • April 22, 2017
  • 11:30 PM
  • 58 views

Intrinsic Motivation Is Caused by Achievement

by Joshua Fisher in Text Savvy

Education interventions (specifically those dealing with mathematics education) designed to increase achievement may be better uses of time than those designed to increase intrinsic motivation.... Read more »

  • April 22, 2017
  • 06:14 AM
  • 51 views

Autistic adults as critical autism experts (with research caveats)

by Paul Whiteley in Questioning Answers

"Findings suggest that autistic adults should be considered autism experts and involved as partners in autism research."That was the conclusion reached in the paper by Kristen Gillespie-Lynch and colleagues [1] (open-access) reporting on the results of an online survey assessing "autism knowledge and stigma among 636 adults with varied relationships to autism, including autistic people and nuclear family members." Among the various groups of people who contributed to the survey, several vie........ Read more »

Gillespie-Lynch, K., Kapp, S., Brooks, P., Pickens, J., & Schwartzman, B. (2017) Whose Expertise Is It? Evidence for Autistic Adults as Critical Autism Experts. Frontiers in Psychology. DOI: 10.3389/fpsyg.2017.00438  

  • April 21, 2017
  • 06:26 AM
  • 45 views

History of neuroscience: John Hughlings Jackson

by neurosci in Neuroscientifically Challenged















In 1860, when John Hughlings Jackson was just beginning his career as a physician, neurology did not yet exist as a medical specialty. In fact, at that time there had been little attention paid to developing a standard approach to treating patients with neurological disease. Such an approach was one of Jackson's greatest contributions to neuroscience. He advocated for examining each patient individually in an attempt to iden........ Read more »

York GK, Steinberg DA. (2007) An Introduction to the Life and Work of John Hughlings Jackson. Med Hist Suppl., 3-34. info:/

  • April 21, 2017
  • 04:32 AM
  • 67 views

Parental exposures and risk of offspring autism: some curious details

by Paul Whiteley in Questioning Answers

"Overall, our results were consistent with no positive association between parental asthmagen exposure and ASD [autism spectrum disorder] in the children."So said the findings reported by Alison Singer and colleagues [1] (open-access) continuing a research theme from this group [2] looking at whether "parental workplace exposures to risk factors for asthma (“asthmagens”)" might have relevance to offspring risk for autism.Based on data derived from some of those oh-so-important Scan........ Read more »

  • April 20, 2017
  • 05:19 AM
  • 79 views

DHM attenuates obesity-induced slow-twitch-fiber decrease via FLCN/FNIP1/AMPK pathway

by Joana Guedes in BHD Research Blog

Obesity is often associated with decreases in the proportion of skeletal muscle slow-twitch fibers and insulin sensitivity. Slow-twitch fibers are rich in mitochondria and utilize fatty acid oxidative phosphorylation for energy production. In their new study, Zhou et al. (2017) explore the role of the FLCN/FNIP1/AMPK signalling pathway in obesity-induced reductions in slow-twitch fibers and insulin sensitivity in skeletal muscle using high-fat-diet-induced (HFD) obese mice, ob/ob mutant mice, an........ Read more »

  • April 20, 2017
  • 04:37 AM
  • 72 views

"a gradual decline in recorded diagnoses of CFS/ME since 2001"?

by Paul Whiteley in Questioning Answers

The quote forming the title of today's post comes from the paper by Simon Collin and colleagues [1] (open-access available here) who, based on analysis of the UK "Clinical Practice Research Datalink (CPRD), formerly known as the General Practice Research Database (GPRD)" set out to look at the "Incidence of CFS/ME [chronic fatigue syndrome/ myalgic encephalomyelitis], FM [fibromyalgia], post-viral fatigue syndrome (PVFS), and asthenia/debility." I say incidence but that last sentence s........ Read more »

  • April 19, 2017
  • 04:31 AM
  • 98 views

Allergy and ADHD meta-analysed and guess what...

by Paul Whiteley in Questioning Answers

"Reports of frequent manifestation of allergic diseases in children with attention deficit hyperactivity disorder (ADHD) have been the subject of mounting clinical interest."OK, go on."The objective of this study was to compile and assess available studies on the association between ADHD and allergic diseases in children."And your findings... "children with ADHD are more likely to have asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis than their counterparts. Intervention........ Read more »

  • April 18, 2017
  • 04:21 AM
  • 117 views

"Asthma was associated with increased risk for schizophrenia"

by Paul Whiteley in Questioning Answers

'Big data' Taiwan is once again the topic of a post on this blog as the results published by Wei-Chen Wang and colleagues [1] (open-access available here) receive an airing, specifically that: "Asthma was associated with increased risk for schizophrenia."There are some common themes attached to these findings. Taiwan is already a research-favourite place on this blog as a result of their use of the National Health Insurance Research Database (NHIRD) for various research purposes. I can't na........ Read more »

Wang WC, Lu ML, Chen VC, Ng MH, Huang KY, Hsieh MH, Hsieh MJ, McIntyre RS, Lee Y, & Lee CT. (2017) Asthma, corticosteroid use and schizophrenia: A nationwide population-based study in Taiwan. PloS one, 12(3). PMID: 28350822  

  • April 17, 2017
  • 03:00 PM
  • 120 views

The continuing trials and tribulations of PACE

by Paul Whiteley in Questioning Answers

I honestly hadn't intended talking about the PACE trial - "pacing, graded activity, and cognitive behaviour therapy: a randomised evaluation" in relation to chronic fatigue syndrome (CFS) - quite so much on this blog. Others have done it so much better than I ever could.My interest however keeps being piqued in relation to the results originally produced suggesting that: "CBT [cognitive behaviour therapy] and GET [graded exercise therapy] can safely be added to SMC to mo........ Read more »

White, P., Chalder, T., Sharpe, M., Angus, B., Baber, H., Bavinton, J., Burgess, M., Clark, L., Cox, D., DeCesare, J.... (2017) Response to the editorial by Dr Geraghty. Journal of Health Psychology, 2147483647. DOI: 10.1177/1359105316688953  

  • April 15, 2017
  • 04:12 PM
  • 152 views

Perspectives…

by Sergio Graziosi in Writing my own user manual - Sergio Graziosi's Blog

In the past few months I’ve spent some time looking for trouble on Twitter. I’ve found some (mild and polite), which translated into plenty food for thought, and eventually allowed me to put some order in my thoughts. The matter…Read more ›... Read more »

Kahneman, D. (2011) Thinking, Fast and Slow. Farrar, Straus and Giroux. info:other/978-0374275631

  • April 14, 2017
  • 08:58 AM
  • 165 views

Well below 1%

by Marco Frasca in The Gauge Connection

When a theory is too hard to solve people try to consider lower dimensional cases. This also happened for Yang-Mills theory. The four dimensional case is notoriously difficult to manage due to the large coupling and the three dimensional case has been treated both theoretically and by lattice computations. In this latter case, the ground […]... Read more »

Andreas Athenodorou, & Michael Teper. (2017) SU(N) gauge theories in 2 1 dimensions: glueball spectra and kstring tensions. J. High Energ. Phys., 15. arXiv: 1609.03873v1

Marco Frasca. (2015) Quantum Yang-Mills field theory. Eur. Phys. J. Plus (2017) 132: 38. arXiv: 1509.05292v2

  • April 13, 2017
  • 04:40 AM
  • 177 views

Video Interaction for Promoting Positive Parenting in autism: yes but not quite...

by Paul Whiteley in Questioning Answers

"Video feedback may help babies ‘at risk of autism’" went one write-up of the study results published by Jonathan Green and colleagues [1] (open-access available here). Continuing a theme of kids at risk of autism potentially 'avoiding' an autism diagnosis (see here) following the use of "a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive ........ Read more »

Green J, Pickles A, Pasco G, Bedford R, Wan MW, Elsabbagh M, Slonims V, Gliga T, Jones EJ, Cheung CH.... (2017) Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years. Journal of child psychology and psychiatry, and allied disciplines. PMID: 28393350  

  • April 12, 2017
  • 10:59 AM
  • 200 views

Flyfocals: Vision and Vectors Help Hunting Robber Flies

by Melissa Chernick in Science Storiented

Image credit: Thomas ShahanRobber flies (Asilidae family) are not your typical house flies. They are small, predatory insects that feed on a vast array of other arthropods. While they are small in size (10 times smaller than a dragonfly), these guys are serious hunters. For example, Mallophora omboides is known as the “Florida bee killer” for its taste for honey bees. Other robber flies hunt down wasps, dragonflies, spiders, or grasshoppers, just to name a few. Perhaps almost as impressive a........ Read more »

Wardill, T., Fabian, S., Pettigrew, A., Stavenga, D., Nordström, K., & Gonzalez-Bellido, P. (2017) A Novel Interception Strategy in a Miniature Robber Fly with Extreme Visual Acuity. Current Biology, 27(6), 854-859. DOI: 10.1016/j.cub.2017.01.050  

  • April 12, 2017
  • 04:39 AM
  • 203 views

On a 'bidirectional relationship' between depression and autoimmune disorders

by Paul Whiteley in Questioning Answers

"We replicated the finding that autoimmune disorders are frequently comorbid with depression, using a longitudinal national birth cohort and self-report data, which is increasingly used in the study of depression."So said the findings reported by Jack Euesden and colleagues [1] (open-access) adding further to a growing peer-reviewed literature base [2] citing a 'connection' between immune function/dysfunction and the presentation of psychiatric/behavioural features (see here). And yes,........ Read more »

  • April 11, 2017
  • 10:22 AM
  • 215 views

Risking Limb for Life? (A Guest Post)

by Miss Behavior in The Scorpion and the Frog

By Matthew Whitley Imagine you are walking alone in parking lot, when suddenly somebody grabs you by the arm and flashes a knife, demanding your money. Do you A) scream for help, B) try to wrestle the knife away, or C) remove your arm from your shoulder and make a break for it? Disarming your assailant may seem preferable to dis-arming yourself, but for a lizard option C is a likely response. A lizard tail left behind. Image by Metatron at Wikimedia Commons.You likely have heard before that many........ Read more »

Clause, A., & Capaldi, E. (2006) Caudal autotomy and regeneration in lizards. Journal of Experimental Zoology Part A: Comparative Experimental Biology, 305A(12), 965-973. DOI: 10.1002/jez.a.346  

Gilbert, E., Payne, S., & Vickaryous, M. (2013) The Anatomy and Histology of Caudal Autotomy and Regeneration in Lizards. Physiological and Biochemical Zoology, 86(6), 631-644. DOI: 10.1086/673889  

  • April 11, 2017
  • 09:00 AM
  • 211 views

Looking for clues for past life on Mars

by EE Giorgi in CHIMERAS

NASA's Curiosity Mars. Credits: NASA/JPL-Caltech/MSSSOn August 6, 2012, the NASA Curiosity rover landed on Mars at the base of Mount Sharp, a mountain the size of Kilimanjaro (~19,000 feet) in the middle of Gale Crater. Nina Lanza, space scientist at the Los Alamos National Laboratory, remembers the day well. As part of the team that built ChemCam, one of the ten instruments on the rover, she spent three months at the Jet Propulsion Laboratory in California, living on “Mars time” to fol........ Read more »

Ricardo, A. (2004) Borate Minerals Stabilize Ribose. Science, 303(5655), 196-196. DOI: 10.1126/science.1092464  

Stephenson, J., Hallis, L., Nagashima, K., & Freeland, S. (2013) Boron Enrichment in Martian Clay. PLoS ONE, 8(6). DOI: 10.1371/journal.pone.0064624  

  • April 11, 2017
  • 06:34 AM
  • 207 views

How Electron Beams Produce Continuous Coherent Plasma Emission by H. Che, M. Goldstein, P. Diamond, and R. Sagdeev

by CESRA in Solar Radio Science

It is commonly accepted that energetic electron beams can produce drift frequency radio emission or Type III bursts since Ginzburg and Zhelezniakov first proposed the idea in 1958. However, the electron two-stream instability time (see reference 2) in the corona is fraction of a second, while the duration of coronal Type III bursts lasts several orders of magnitude longer. This problem is called the “Sturrock Dilemma” and remains a subject [...]... Read more »

  • April 11, 2017
  • 04:02 AM
  • 188 views

Risk of death by injury and autism

by Paul Whiteley in Questioning Answers

"Individuals with autism appear to be at substantially heightened risk for death from injury."That was the research bottom line published by Joseph Guan & Guohua Li [1] from Columbia University Medical Center, who trawled the accumulated data included in the US National Vital Statistics System screening death certificates issued between 1999 and 2014. Of the approximate 32 million death certificates issued, researchers found that some 1300 people diagnosed as on the autis........ Read more »

Guan, J., & Li, G. (2017) Injury Mortality in Individuals With Autism. American Journal of Public Health. DOI: 10.2105/AJPH.2017.303696  

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