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  • April 17, 2017
  • 04:00 PM

The continuing trials and tribulations of PACE

by Paul Whiteley in Questioning Answers

I honestly hadn't intended talking about the PACE trial - "pacing, graded activity, and cognitive behaviour therapy: a randomised evaluation" in relation to chronic fatigue syndrome (CFS) - quite so much on this blog. Others have done it so much better than I ever could.My interest however keeps being piqued in relation to the results originally produced suggesting that: "CBT [cognitive behaviour therapy] and GET [graded exercise therapy] can safely be added to SMC to mo........ Read more »

White, P., Chalder, T., Sharpe, M., Angus, B., Baber, H., Bavinton, J., Burgess, M., Clark, L., Cox, D., DeCesare, J.... (2017) Response to the editorial by Dr Geraghty. Journal of Health Psychology, 2147483647. DOI: 10.1177/1359105316688953  

  • April 17, 2017
  • 02:00 PM

The emergence of the alternative metric that can make the measurement of world academic production more fair and egalitarian

by SciELO in SciELO in Perspective | Press Releases

The growing use of social networks for various purposes, including the dissemination of scientific communication, has required the creation of a new method of measuring and analyzing the flow of information in these environments. Altmetria emerged as a subarea of Metrics Information Studies to meet this need, and can complement traditional methods of evaluation, thus making it more fair and egalitarian. … Read More →... Read more »

  • April 15, 2017
  • 05:12 PM


by Sergio Graziosi in Writing my own user manual - Sergio Graziosi's Blog

In the past few months I’ve spent some time looking for trouble on Twitter. I’ve found some (mild and polite), which translated into plenty food for thought, and eventually allowed me to put some order in my thoughts. The matter…Read more ›... Read more »

Kahneman, D. (2011) Thinking, Fast and Slow. Farrar, Straus and Giroux. info:other/978-0374275631

  • April 13, 2017
  • 05:40 AM

Video Interaction for Promoting Positive Parenting in autism: yes but not quite...

by Paul Whiteley in Questioning Answers

"Video feedback may help babies ‘at risk of autism’" went one write-up of the study results published by Jonathan Green and colleagues [1] (open-access available here). Continuing a theme of kids at risk of autism potentially 'avoiding' an autism diagnosis (see here) following the use of "a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive ........ Read more »

Green J, Pickles A, Pasco G, Bedford R, Wan MW, Elsabbagh M, Slonims V, Gliga T, Jones EJ, Cheung CH.... (2017) Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years. Journal of child psychology and psychiatry, and allied disciplines. PMID: 28393350  

  • April 12, 2017
  • 05:39 AM

On a 'bidirectional relationship' between depression and autoimmune disorders

by Paul Whiteley in Questioning Answers

"We replicated the finding that autoimmune disorders are frequently comorbid with depression, using a longitudinal national birth cohort and self-report data, which is increasingly used in the study of depression."So said the findings reported by Jack Euesden and colleagues [1] (open-access) adding further to a growing peer-reviewed literature base [2] citing a 'connection' between immune function/dysfunction and the presentation of psychiatric/behavioural features (see here). And yes,........ Read more »

  • April 11, 2017
  • 05:02 AM

Risk of death by injury and autism

by Paul Whiteley in Questioning Answers

"Individuals with autism appear to be at substantially heightened risk for death from injury."That was the research bottom line published by Joseph Guan & Guohua Li [1] from Columbia University Medical Center, who trawled the accumulated data included in the US National Vital Statistics System screening death certificates issued between 1999 and 2014. Of the approximate 32 million death certificates issued, researchers found that some 1300 people diagnosed as on the autis........ Read more »

Guan, J., & Li, G. (2017) Injury Mortality in Individuals With Autism. American Journal of Public Health. DOI: 10.2105/AJPH.2017.303696  

  • April 10, 2017
  • 05:27 AM

"Predisposition" to autoimmunity and inflammatory activation linked to autistic regression?

by Paul Whiteley in Questioning Answers

The paper by Ori Scott and colleagues [1] provides some very welcome interest in the concept of regression in relation to autism. As I've indicated quite a few times on this blog, regression accompanying cases of autism has [finally] been accepted by the research community at large (see here for example) but there is still some way to go with regards to the hows-and-whys of regression. There are some clues (see here) but more data is required. What the evidence available so far suggests is ........ Read more »

  • April 8, 2017
  • 05:13 AM

One more time folks... pregnancy folate and autism risk

by Paul Whiteley in Questioning Answers

Folate yet again on this blog? Sorry but that's just how the peer-reviewed papers have fallen..."Maternal folate supplementation during pregnancy may reduce the risk of ASD [autism spectrum disorder] in the offspring, especially in the Western population."So said the meta-analysis by Yu and colleagues [1] reporting on a topic that has seen quite a lot of research interest down the years (see here). Authors this time around cumulatively examined data for some 4,500 cases of autism compared w........ Read more »

  • April 7, 2017
  • 04:02 PM

Outsourcing and precariousness of work in the social assistance policy

by SciELO in SciELO in Perspective | Press Releases

This paper presents the work conditions of psychologists hired by private organizations to work at the Sistema Único de Assistência Social (Unified System for Social Assistance). Among other things, it concludes that this “outsourcing” process has been allowing temporary contracts, high turnover rates, late payment of salaries, dismissal of large groups of employees and lack of continuing education, which impacts the health of the workers and the quality of the services offered. … Re........ Read more »

  • April 7, 2017
  • 08:02 AM

Which science is most “certain” according to the American public? 

by Rita Handrich in The Jury Room

When litigation cases rely on science or highly technical information, it is critical to help jurors understand the information underlying the case at a level that makes sense to them. If they do not understand your “science”, they will simply guess which party to vote for or “follow the crowd”. Here’s an example of what […]... Read more »

Broomell, S., & Kane, P. (2017) Public perception and communication of scientific uncertainty. Journal of Experimental Psychology: General, 146(2), 286-304. DOI: 10.1037/xge0000260  

  • April 7, 2017
  • 05:48 AM

Folate-dependent one carbon metabolism and transsulfuration pathways: biomarkers for autism?

by Paul Whiteley in Questioning Answers

I found it a little unusual that the findings reported by Daniel Howsmon and colleagues [1] (open-access) talking about "multivariate statistical analysis presented herein [provided] unprecedented quantitative classification results for separating participants into ASD [autism spectrum disorder] and NEU [neurotypical] cohorts based solely on biochemical data" merited a rapid reply in a prominent science magazine pouring cold water on the results (see here). Not least bec........ Read more »

  • April 6, 2017
  • 03:44 AM

"a single intravenous infusion of autologous umbilical cord blood" and autism

by Paul Whiteley in Questioning Answers

'Could stem cells offer hope for autism?' went one media headline referencing the very preliminary "phase I, open-label trial" published by Geraldine Dawson and colleagues [1] (open-access) detailing the experiences of a single intravenous infusion of autologous umbilical cord blood in 25 children with "a confirmed diagnosis of ASD [autism spectrum disorder]."Well, the results were promising in respect of important issues such as safety in light of the tenet 'first do no harm': "Assess........ Read more »

Geraldine Dawson, Jessica M. Sun, Katherine S. Davlantis, Michael Murias,, Lauren Franz, Jesse Troy, Ryan Simmons, Maura Sabatos-DeVito, Rebecca Durham, & Joanne Kurtzberg. (2017) Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial. Stem Cells Translational Medicine. info:/10.1002/sctm.16-0474

  • April 5, 2017
  • 08:02 AM

Your Black client is much more likely to be wrongfully convicted

by Doug Keene in The Jury Room

Those of us who’ve been around for a while have heard this repeatedly. But, lest you think times are changing, here’s some sobering data from a March, 2017 report co-edited by a Michigan State University College of Law Professor. From the beginning, this is a disturbing report. Here’s how it starts: African-Americans are only 13% […]... Read more »

Samuel R. Gross, Maurice Possley, & Klara Stephens. (2017) Race and Wrongful Convictions in the United States. . UC Irvine: National Registry of Exonerations. . info:/

  • April 5, 2017
  • 04:14 AM

Paediatric congenital heart disease and autism risk (again)

by Paul Whiteley in Questioning Answers

"Risk of autism spectrum disorder screening status in children with congenital heart defects was higher than expected from population rates."So said the findings reported by Jessica Bean Jaworski and colleagues [1] who set about "to assess the rates of autism spectrum disorders in a large sample of children with a history of congenital heart defects and to assess medical, behavioral, and individual factors that may be associated with the risk of autism spectrum disorders." Covering a topic that ........ Read more »

Bean Jaworski JL, Flynn T, Burnham N, Chittams JL, Sammarco T, Gerdes M, Bernbaum JC, Clancy RR, Solot CB, Zackai EH.... (2017) Rates of autism and potential risk factors in children with congenital heart defects. Congenital heart disease. PMID: 28299880  

  • April 4, 2017
  • 12:00 PM

Researchers Finally Ask: Does Your Cat Even Like To Be Around You?

by Miss Behavior in The Scorpion and the Frog

This cat has had enough and is running away from home. Photo by Danielle Menuey.While dogs happily and obliviously boast the reputation of being “man’s best friend”, cats have a reputation of being antisocial, independent, and downright grumpy. But do cats really deserve that? Scientists finally decided to find out.Kristin Vitale Shreve and Monique Udell from Oregon State University and Lindsay Mehrkam from Monmouth University asked 25 pet cats and 25 shelter cats their preferences. H........ Read more »

  • April 4, 2017
  • 03:55 AM

Autism, ageing and comorbidity

by Paul Whiteley in Questioning Answers

I'm not spending too much time today on the findings published by Elizabeth Wise and colleagues [1] but did want to bring them to your attention. Looking at the presentation of "comorbidities and behavioral and neuropsychiatric symptoms" in relation to autism in the context of ageing, some important details were noted. Not least that "GI [gastrointestinal] disorders (68.9%) and seizure disorders (23%) were common, and 25.7% of the sample had a BMI [body mass index] >30" wh........ Read more »

  • April 3, 2017
  • 02:00 PM

Medical practice precariousness at the Unified Health System — SUS

by SciELO in SciELO in Perspective | Press Releases

The medical practice in the Unified Health System is a study topic published in the journal Estudos de Psicologia (Campinas), which reveals the working conditions of these professionals and the impacts on personal health, analyzed through interviews and self-confidence. … Read More →... Read more »

  • April 3, 2017
  • 11:59 AM

Criminal defense? Brain scans could show whether “they did it  on purpose”

by Rita Handrich in The Jury Room

When my kids were younger, I used to talk to them about the difference between intent and impact as they struggled to understand the varying reactions of people to their behavior. Back in 2009, we posted on some new research showing that we reacted more indignantly when bad deeds were done “on purpose”. Here is […]... Read more »

Vilares I, Wesley MJ, Ahn WY, Bonnie RJ, Hoffman M, Jones OD, Morse SJ, Yaffe G, Lohrenz T, & Montague PR. (2017) Predicting the knowledge-recklessness distinction in the human brain. Proceedings of the National Academy of Sciences of the United States of America, 114(12), 3222-3227. PMID: 28289225  

  • April 3, 2017
  • 04:10 AM

Decreased urinary creatinine levels associated with autism (again)

by Paul Whiteley in Questioning Answers

One finding in particular stood out from those reported by Lussu and colleagues [1] following some nifty metabolomic investigations: decreased levels of urinary creatinine in their cohort of participants diagnosed as on the autism spectrum (n=21) compared with "controls (n = 21), these being siblings of autistic patients."Based on the "use of 1 H-NMR metabolomics to analyze the global biochemical signature of ASD [autism spectrum disorder] patients" researchers turned again to a fa........ Read more »

Lussu M, Noto A, Masili A, Rinaldi AC, Dessì A, De Angelis M, De Giacomo A, Fanos V, Atzori L, & Francavilla R. (2017) The urinary 1 H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings. Autism research : official journal of the International Society for Autism Research. PMID: 28296209  

  • April 2, 2017
  • 07:17 AM

The perfect multilingual

by Madalena Cruz-Ferreira in Being Multilingual

P { margin-bottom: 0.08in; } In case you’re wondering, let me reassure you straight away that yes, the title of this post is meant to be sarcastic. Perfect multilinguals do exist, of course, though only in the minds of those of us who mistake ideals of perfection for reality. Multilingual perfection awardees must satisfy a number of criteria. If you are, or were, a language learner as an adult, forget it: not having acquired all of your languages as a young child automatically makes you a n........ Read more »

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