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  • April 4, 2014
  • 04:41 PM
  • 455 views

MERS-CoV orf4a -an antagonist of antiviral signaling

by thelonevirologist in Virology Tidbits

As mentioned in a previous entry MERS-CoV is capable to inhibit antiviral signaling by antagonizing interferon signaling pathways which are induced by the recognition of dsRNA by intracellular pathogen-associated molecular pattern (PAMP) receptors. Although having a ssRNA genome, dsRNA is produced during Coronavirus replication as an intermediate and thus can be recognized by Toll-like receptors -3 and -9 (TLR-3/TLR-9). ... Read more »

Niemeyer D, Zillinger T, Muth D, Zielecki F, Horvath G, Suliman T, Barchet W, Weber F, Drosten C, & Müller MA. (2013) Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist. Journal of virology, 87(22), 12489-95. PMID: 24027320  

Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, & Fujita T. (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature immunology, 5(7), 730-7. PMID: 15208624  

  • April 2, 2014
  • 05:52 PM
  • 477 views

MERS-CoV and SARS-CoV: two members of a divergent family

by thelonevirologist in Virology Tidbits

Coronavirus infections are commonly associated with relative benign respiratory and enteric diseases in humans, such as the common cold, and with outbreaks among agricultural livestock -chickens, swine or cattle. The outbreak of a novel disease in humans, severe acute respiratory syndrome (SARS), in 2003 however highlighted the potential lethal consequences of Coronavirus (CoV) induced disease in the human population.
... Read more »

Pyrc, K., Berkhout, B., & van der Hoek, L. (2006) The Novel Human Coronaviruses NL63 and HKU1. Journal of Virology, 81(7), 3051-3057. DOI: 10.1128/JVI.01466-06  

Golda A, Malek N, Dudek B, Zeglen S, Wojarski J, Ochman M, Kucewicz E, Zembala M, Potempa J, & Pyrc K. (2011) Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells. The Journal of general virology, 92(Pt 6), 1358-68. PMID: 21325482  

Ge XY, Li JL, Yang XL, Chmura AA, Zhu G, Epstein JH, Mazet JK, Hu B, Zhang W, Peng C.... (2013) Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 503(7477), 535-8. PMID: 24172901  

de Wilde AH, Raj VS, Oudshoorn D, Bestebroer TM, van Nieuwkoop S, Limpens RW, Posthuma CC, van der Meer Y, Bárcena M, Haagmans BL.... (2013) MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment. The Journal of general virology, 94(Pt 8), 1749-60. PMID: 23620378  

  • March 29, 2014
  • 06:50 PM
  • 435 views

Human cancers and viruses: 50 years of Epstein Barr Virus

by thelonevirologist in Virology Tidbits

March marked the 50th anniversary of the discovery of Epstein-Barr Virus (EBV) - an anniversary which the author of this blog almost missed, wouldn’t it have been for an article published Science on March 21st.... Read more »

Butel, J., & Fan, H. (2012) The diversity of human cancer viruses. Current Opinion in Virology, 2(4), 449-452. DOI: 10.1016/j.coviro.2012.07.002  

Hammerschmidt, W., & Sugden, B. (2013) Replication of Epstein-Barr Viral DNA. Cold Spring Harbor Perspectives in Biology, 5(1). DOI: 10.1101/cshperspect.a013029  

Daikoku T, Kudoh A, Fujita M, Sugaya Y, Isomura H, Shirata N, & Tsurumi T. (2005) Architecture of replication compartments formed during Epstein-Barr virus lytic replication. Journal of virology, 79(6), 3409-18. PMID: 15731235  

Tsurumi, T., Fujita, M., & Kudoh, A. (2005) Latent and lytic Epstein-Barr virus replication strategies. Reviews in Medical Virology, 15(1), 3-15. DOI: 10.1002/rmv.441  

Arnaud F, Varela M, Spencer TE, & Palmarini M. (2008) Coevolution of endogenous betaretroviruses of sheep and their host. Cellular and molecular life sciences : CMLS, 65(21), 3422-32. PMID: 18818869  

Allison AB, Kevin Keel M, Philips JE, Cartoceti AN, Munk BA, Nemeth NM, Welsh TI, Thomas JM, Crum JM, Lichtenwalner AB.... (2014) Avian oncogenesis induced by lymphoproliferative disease virus: a neglected or emerging retroviral pathogen?. Virology, 2-12. PMID: 24503062  

Fuentes-González, A., Contreras-Paredes, A., Manzo-Merino, J., & Lizano, M. (2013) The modulation of apoptosis by oncogenic viruses. Virology Journal, 10(1), 182. DOI: 10.1186/1743-422X-10-182  

  • March 28, 2014
  • 01:35 PM
  • 42 views

What’s the best diet to get rid of acne?

by Stuart Farrimond in Guru: Science Blog

Forget the ‘golden days of childhood’, I’ve always thought that being an adult is so much better. For one thing, who would want all the zits, spots, pimples and pustules that afflict adolescence? (I was one of the unlucky ones.) […]The post What’s the best diet to get rid of acne? appeared first on Guru Magazine.... Read more »

Spencer, E., Ferdowsian, H., & Barnard, N. (2009) Diet and acne: a review of the evidence. International Journal of Dermatology, 48(4), 339-347. DOI: 10.1111/j.1365-4632.2009.04002.x  

  • March 28, 2014
  • 09:57 AM
  • 459 views

Patching the Leaky Pipeline of Women in STEM

by amikulak in Daily Observations

March is designated Women’s History Month in the United States, recognizing “generations of women whose commitment to nature and the planet have proved invaluable to society.” And yet, as we […]... Read more »

  • March 26, 2014
  • 06:45 PM
  • 329 views

The Ugly Ducklings of Science

by Neuroskeptic in Neuroskeptic_Discover

A group of management researchers provide new evidence of a worrying bias in the scientific process – The Chrysalis Effect: How Ugly Initial Results Metamorphosize Into Beautiful Articles ( via Retraction Watch ) The issue they highlight – the ability of researchers to eventually squeeze support for a theory out of initially negative data – […]The post The Ugly Ducklings of Science appeared first on Neuroskeptic.... Read more »

  • March 26, 2014
  • 05:04 PM
  • 326 views

Encephalitis lethargica and Influenza: a case of mistaken identity with a twist

by thelonevirologist in Virology Tidbits

Following the Influenza epidemic in 1918, physicians observed an increase in cases of Encephalitis lethargica (EL), the acute (often lethal) phase followed by post encephalitic parkinsonism (PEP), the latter affecting patients for several decades.

Based on the observation that these patients might have been infected with the 1918 Influenza virus, the conclusion was reached that a long-term consequence of Influenza might be the development of a neurological disease. ... Read more »

Ward AC. (1996) Neurovirulence of influenza A virus. Journal of neurovirology, 2(3), 139-51. PMID: 8799206  

Nichols JE, Niles JA, & Roberts NJ Jr. (2001) Human lymphocyte apoptosis after exposure to influenza A virus. Journal of virology, 75(13), 5921-9. PMID: 11390593  

Dale RC, Church AJ, Surtees RA, Lees AJ, Adcock JE, Harding B, Neville BG, & Giovannoni G. (2004) Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity. Brain : a journal of neurology, 127(Pt 1), 21-33. PMID: 14570817  

  • March 25, 2014
  • 12:02 AM
  • 384 views

“I am Working-Class”: Self-Identification as a Measure of Social Class in Educational Research

by Mark Rubin in Mark Rubin's Social Psychology Research Blog

Governments around the world are trying to open up higher education to working-class people. For example, in January this year, the White House released a report titled: "Increasing college opportunity for low-income students: Promising models and a call to action." In the context of this general push towards widening participation in higher education, my colleagues and I have been developing a research project that aims to investigate social class differences in social integration among student........ Read more »

  • March 24, 2014
  • 04:30 PM
  • 450 views

Molecular aspects of Ebola and other Filoviruses

by thelonevirologist in Virology Tidbits

In the last few days news organizations reported an outbreak of Ebola in West Africa, leading (as of March 24th) to a death of 59 out of 80 infected people. The Ebola virus and its variant Marburg virus are known to be one the most lethal viruses infecting humans. Once infected patients die of hemorrhagic fever, a painful and agonizing death characterized by fever, excessive blood loss and diarrhea. There is no effective therapy, except replacing fluids, blood, coagualnts as well as relativ........ Read more »

Mühlberger E. (2007) Filovirus replication and transcription. Future virology, 2(2), 205-215. PMID: 24093048  

Kiley MP, Bowen ET, Eddy GA, Isaäcson M, Johnson KM, McCormick JB, Murphy FA, Pattyn SR, Peters D, Prozesky OW.... (1982) Filoviridae: a taxonomic home for Marburg and Ebola viruses?. Intervirology, 18(1-2), 24-32. PMID: 7118520  

Hoenen T, Shabman RS, Groseth A, Herwig A, Weber M, Schudt G, Dolnik O, Basler CF, Becker S, & Feldmann H. (2012) Inclusion bodies are a site of ebolavirus replication. Journal of virology, 86(21), 11779-88. PMID: 22915810  

Iwasa A, Halfmann P, Noda T, Oyama M, Kozuka-Hata H, Watanabe S, Shimojima M, Watanabe T, & Kawaoka Y. (2011) Contribution of Sec61α to the life cycle of Ebola virus. The Journal of infectious diseases. PMID: 21987770  

  • March 23, 2014
  • 02:30 PM
  • 448 views

Nanopillars of nanotubes! A novel method to drastically improve charge transport in hybrid nanotube devices

by Jonathan Trinastic in Goodnight Earth

A new article demonstrates a method to drastically increase the conductivity of hybrd CNT-polymer devices using nano-engineering!... Read more »

  • March 21, 2014
  • 06:52 PM
  • 284 views

Influenza and the Great War: a contribution to the centenary of the Great War

by thelonevirologist in Virology Tidbits

This year marks the centenary of the beginning of the Great War -or outside of Great Britain more commonly known as World War 1 - so I think it is time to look at a chapter of the war often neglected. Instead of focusing on the beginning of the war, I would like to draw attention to the end of the war in 1918 – in particular on Germany whose defeat in 1918 coincided with the Influenza epidemic.The influenza epidemic of 1918/1919 became widely known as the “Spanish Influenza”, a title misle........ Read more »

Oxford JS, Sefton A, Jackson R, Innes W, Daniels RS, & Johnson NP. (2002) World War I may have allowed the emergence of "Spanish" influenza. The Lancet infectious diseases, 2(2), 111-4. PMID: 11901642  

Erkoreka A. (2009) Origins of the Spanish Influenza pandemic (1918-1920) and its relation to the First World War. Journal of molecular and genetic medicine : an international journal of biomedical research, 3(2), 190-4. PMID: 20076789  

  • March 19, 2014
  • 04:00 PM
  • 284 views

Archaeovirology: Solving the riddles of the past

by thelonevirologist in Virology Tidbits

In recent years the advent of modern technology allowed researchers to amplify ancient DNA from a variant of organisms - organisms ranging from Homo (sapiens) neanderthalensis (more commonly known as the Neanderthal) to insects enclosed in amber. Common problems found is the scarcity of DNA due to the age of the specimen and problems of contamination with foreign DNA , the latter being a problem if human specimens are involved. In terms of pathogens, a recent paper in Scientific Reports research........ Read more »

Raoult D, Dutour O, Houhamdi L, Jankauskas R, Fournier PE, Ardagna Y, Drancourt M, Signoli M, La VD, Macia Y.... (2006) Evidence for louse-transmitted diseases in soldiers of Napoleon's Grand Army in Vilnius. The Journal of infectious diseases, 193(1), 112-20. PMID: 16323139  

Devault AM, McLoughlin K, Jaing C, Gardner S, Porter TM, Enk JM, Thissen J, Allen J, Borucki M, Dewitte SN.... (2014) Ancient pathogen DNA in archaeological samples detected with a Microbial Detection Array. Scientific reports, 4245. PMID: 24603850  

Weingartl HM, Albrecht RA, Lager KM, Babiuk S, Marszal P, Neufeld J, Embury-Hyatt C, Lekcharoensuk P, Tumpey TM, García-Sastre A.... (2009) Experimental infection of pigs with the human 1918 pandemic influenza virus. Journal of virology, 83(9), 4287-96. PMID: 19224986  

Legendre M, Bartoli J, Shmakova L, Jeudy S, Labadie K, Adrait A, Lescot M, Poirot O, Bertaux L, Bruley C.... (2014) Thirty-thousand-year-old distant relative of giant icosahedral DNA viruses with a pandoravirus morphology. Proceedings of the National Academy of Sciences of the United States of America. PMID: 24591590  

Philippe N, Legendre M, Doutre G, Couté Y, Poirot O, Lescot M, Arslan D, Seltzer V, Bertaux L, Bruley C.... (2013) Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of parasitic eukaryotes. Science (New York, N.Y.), 341(6143), 281-6. PMID: 23869018  

  • March 18, 2014
  • 12:10 PM
  • 84 views

Protein magician detangles DNA and also primes genes in stem cells

by Amanda Alvarez in IMB Blog

Topoisomerases stretch and untangle DNA. Scientists at IMB have found new functions for these proteins in young stem cells and mature differentiated cells.... Read more »

Thakurela, S., Garding, A., Jung, J., Schübeler, D., Burger, L., & Tiwari, V. (2013) Gene regulation and priming by topoisomerase IIα in embryonic stem cells. Nature Communications. DOI: 10.1038/ncomms3478  

  • March 17, 2014
  • 12:49 AM
  • 446 views

AIS-INMACA: A Novel Integrated MACA Based Clonal Classifier for Protein Coding and Promoter Region Prediction

by JBCG in JScholar Publishers

Most of the problems in bioinformatics are now the challenges in computing. This paper aims at building a classifier based on Multiple Attractor Cellular Automata (MACA) which uses fuzzy logic. It is strengthened with an artificial Immune System Technique (AIS), Clonal algorithm for identifying a protein coding and promoter region in a given DNA sequence.... Read more »

Pokkuluri Kiran Sree*, Inampudi Ramesh Babu, SSSN Usha Devi N. (2014) AIS-INMACA: A Novel Integrated MACA Based Clonal Classifier for Protein Coding and Promoter Region Prediction. JOURNAL OF BIOINFORMATICS AND COMPARATIVE GENOMICS, 1(1), 1-7. info:/JBCG 1: 104

  • March 14, 2014
  • 11:43 AM
  • 588 views

Do other animals experience pleasurable female orgasms?

by Stuart Farrimond in Guru: Science Blog

Yes, other species experience pleasurable female orgasms, or at least it appears that way. It is hard, after all, to ask the female chimp after her artificial ‘stimulation’ in the lab how it felt. But the signs are all there […]The post Do other animals experience pleasurable female orgasms? appeared first on Guru Magazine.... Read more »

  • March 14, 2014
  • 12:07 AM
  • 793 views

Transcriptome, transcription factors and transcriptional regulation of leaf senescence

by JBCG in JScholar Publishers

Senescence is the last stage of development of a leaf, and is critical for plants’ evolutionary fitness as nutrient remobilization to other organs of a plant is achieved through this process. The leaf senescence process is believed to be under the control of a highly regulated genetic program which is associated with drastic changes of gene expression. Major breakthroughs in the molecular understanding of leaf senescence have been achieved through analyses of the transcriptome and transcri........ Read more »

Wei Li, Yongfeng Guo. (2014) Transcriptome, transcription factors and transcriptional regulation of leaf senescence. JOURNAL OF BIOINFORMATICS AND COMPARATIVE GENOMICS, 1(1), 1-3. info:/JBCG 1: 103

  • March 13, 2014
  • 01:35 PM
  • 822 views

I gained two stone in weight since stopping smoking 10 months ago – why?

by Stuart Farrimond in Guru: Science Blog

Gaining weight is one of the most feared consequences to stopping smoking. So firstly, good on you for kicking the cigarettes. The majority of people will gain some weight after stopping smoking. On average, ex-smokers put on a couple of […]The post I gained two stone in weight since stopping smoking 10 months ago – why? appeared first on Guru Magazine.... Read more »

  • March 12, 2014
  • 11:46 PM
  • 418 views

Evaluating the Binding Affinity of Juglone on 1kms- An In Silico Approach

by JBCG in JScholar Publishers

Cancer is one of the major causes of deaths seen in the humans. This is one of the major problems which have to be addressed with priority. There are many naturally available drugs for cancer. Juglone is a naturally available plant component which has a host of biological roles. This also has proven to be an anticancer drug. In the present article Juglone and Juglone compounds were docked with 1 KMS to evaluate their binding affinities.... Read more »

Shailima RD Vardhini*. (2014) Evaluating the Binding Affinity of Juglone on 1kms- An In Silico Approach. JOURNAL OF BIOINFORMATICS AND COMPARATIVE GENOMICS, 1(1), 1-2. info:/JBCG 1: 102

  • March 12, 2014
  • 07:41 PM
  • 475 views

Canines and Castles: 4th Canine Science Forum Abstract & Early Bird Registration Deadline Friday

by Cobb & Hecht in Do You Believe In Dog?

“Two canine scientists, Julie Hecht and Mia Cobb, met briefly at a conference in Barcelona in late July 2012. They share a passion for canine science, good communication, social media and fun.” So reads the 'About' page at Do You Believe in Dog?. After a brief hello at the 3rd Canine Science Forum in Barcelona, we decided to embark on an adventure as digital pen pals, taking turns blogging on topics related to our own research, that of other research groups and general dog science themes.&n........ Read more »

Cobb Mia, Branson Nick, & McGreevy Paul. (2013) Advancing the welfare of Australia’s iconic working dogs. Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.054  

Hecht J., & Horowitz A. (2013) Physical prompts to anthropomorphism of the domestic dog (Canis familiaris). Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.013  

Racca A., Range F., Virányi Z., & Huber L. (2013) Discrimination of familiar human faces in domestic dogs. Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.071  

Howell Tiffani J., Toukhsati Samia, Conduit Russell, & Bennett Pauleen. (2013) Do dogs use a mirror to find hidden food?. Journal of Veterinary Behavior: Clinical Applications and Research, 8(6), 425-430. DOI: 10.1016/j.jveb.2013.07.002  

  • March 12, 2014
  • 04:12 PM
  • 385 views

Audience analysis chart

by Olga Vovk in Milchstraße

A helpful way of gathering information about your readers is to conduct an audience analysis using a chart where on the x axis you list all possible and potential audiences you consider and on the y axis list audience analysis questions. ... Read more »

Carrie Ann Koplinka-Loehr. (1984) The Use of Educational Theory in Science Writing: Audience Analysis and Accommodation. Cornell University. info:/

Butcher, G. (2005) Using audience analysis in the development of web sites. American Geophysical Union, Fall Meeting. info:other/#ED53B-01

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