In the comments to what I wrote yesterday about seizures and a study comparing lorazepam (Ativan), diazepam (Valium), and placebo, Brooks Walsh had the following comment –
"Although I’ve read the study before, I am only wondering now how the IRB for Alldredge 2001 thought there was 'equipoise' between placebo and benzos."... Read more »
Alldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, Ulrich S, Gottwald MD, OâNeil N, Neuhaus JM, Segal MR, Lowenstein DH. (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521
Callaway, C. (2012) Questioning the Use of Epinephrine to Treat Cardiac Arrest. JAMA: The Journal of the American Medical Association, 307(11), 1198. DOI: 10.1001/jama.2012.313
Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. (2012) Prehospital Epinephrine Use and Survival Among Patients With Out-of-Hospital Cardiac Arrest. JAMA: The Journal of the American Medical Association, 307(11), 1161. DOI: 10.1001/jama.2012.294
It can be hard job for truck drivers to stay alert while working, so, as you can imagine, they like to consume coffee and energy drinks. But do these really help? A new study took the first step in proving they can.... Read more »
Sharwood LN, Elkington J, Meuleners L, Ivers R, Boufous S, & Stevenson M. (2013) Use of caffeinated substances and risk of crashes in long distance drivers of commercial vehicles: case-control study. BMJ (Clinical research ed.). PMID: 23511947
The paper by Emma Frans and colleagues* looking at autism risk across the generations is the focus of this post. Published in the journal JAMA Psychiatry alongside a provocative article by Andrea Roberts and colleagues** on maternal exposure to child abuse being "associated" with elevated risk for offspring autism (see here and here), the theme is transgenerational effects and quote: "that your father's and grandfather's lifestyle choices can affect you" as per some of media on this paper.Î........ Read more »
Frans, E. (2013) Autism Risk Across GenerationsA Population-Based Study of Advancing Grandpaternal and Paternal AgeAutism Risk. JAMA Psychiatry, 1. DOI: 10.1001/jamapsychiatry.2013.1180
by Shelly Fan in Science of Eating Disorders
In my previous post, I looked at two hormones released during the cephalic phaseÂ (gastric secretion that occurs before food is eaten), ghrelin and obestatin, and how they may contribute to runaway eating behavior. Today Iâm going to be looking at insulin release during chew and spit (CHSP), a fairly common symptom in eating disorders where the food is tasted, chewed and spit out. Insulin is a small peptide hormone that acts as a key regulator of metabolism; deregulation of insulinÂ signalling........ Read more »
Teff KL, & Engelman K. (1996) Palatability and dietary restraint: effect on cephalic phase insulin release in women. Physiology , 60(2), 567-73. PMID: 8840920
Teff KL. (2011) How neural mediation of anticipatory and compensatory insulin release helps us tolerate food. Physiology , 103(1), 44-50. PMID: 21256146
Researchers at Moffitt Cancer Center just announced the results of a phase II clinical trial on patients with with higher-risk myelodysplastic syndrome (MDS), chronic myelomonocytic leukaemia, or acute myeloid leukaemia arising from MDS, who had previously failed to respond to conventional treatment (azanucleosides). Purpose of the trial was to assess the safety and efficacy of dasatinib in treating these conditions. The researchers say that although the drug won't help all patients, it does........ Read more »
Duong, V., Jaglal, M., Zhang, L., Kale, V., Lancet, J., Komrokji, R., & List, A. (2013) Phase II pilot study of oral dasatinib in patients with higher-risk myelodysplastic syndrome (MDS) who failed conventional therapy. Leukemia Research, 37(3), 300-304. DOI: 10.1016/j.leukres.2012.11.001
CrossFit Games Competition and New Research. There have been several new papers out on recovery from repeated sets of resistance exercise. These may be important for people headed to theThe post CrossFit Games Competition: Recovery between WODs appeared first on WODMasters Stiff Competition.... Read more »
Bacon NT, Wingo JE, Richardson MT, Ryan GA, Pangallo TC, & Bishop PA. (2012) Effect of two recovery methods on repeated closed-handed and open-handed weight-assisted pull-ups. Journal of strength and conditioning research / National Strength , 26(5), 1348-52. PMID: 22516908
If you ever find yourself working in an infectious disease laboratory, whether it’s of the diagnostic or research variety, the overarching goal is not to put any microbes in your eye, an open wound or your mouth. Easy enough, right? Wear gloves, maybe goggles, work in fume hoods and don’t mouth pipette. When working with pathogenic bacteria and viruses, priority number one is Do Not Self-Inoculate.
Today our manual pipettes are rather sophisticated, plastic-y devices perfectly cal........ Read more »
HILL, N. (1999) Laboratory-acquired Infections: History, Incidence, Causes and Preventions, 4th edition. Eds. C. H. Collins and D. A. Kennedy. Butterworth Heinemann, Oxford 1999. Pp. 324. ISBN 0 7506 4023 5. Epidemiology and Infection, 123(1), 181-181. DOI: 10.1017/S0950268899002514
by amikulak in Daily Observations
Prevailing wisdom suggests that our genes remain largely fixed over time. But, an emerging field of research is beginning to prove this intuition wrong. Scientists are uncovering increasing evidence that ... Read more »
An estimated 1 in 50 US children aged between 6 - 17 years old present with an autism spectrum disorder (ASD). Attention-grabbing isn't it?Today's post is based on the source of that soundbite, the publication by Stephen Blumberg and colleagues* (open-access) describing results from data mining of the 2007 and 2011-2012 US National Survey of Children's Health (NSCH) relevant to the numbers of cases of ASD.Testing 1, 2, 3 @ Wikipedia The autism-numbers game is something that has been d........ Read more »
Wilson, C., Gillan, N., Spain, D., Robertson, D., Roberts, G., Murphy, C., Maltezos, S., Zinkstok, J., Johnston, K., Dardani, C.... (2013) Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an Adult Autism Spectrum Disorder Diagnostic Clinic. Journal of Autism and Developmental Disorders. DOI: 10.1007/s10803-013-1799-6
Tumours develop a chaotic system of blood vessels to raid the body’s normal blood supply. Some of the latest anti-cancer drugs (Vascular Disrupting Agents) work by damaging these vessels: the tumour is then denied access to nutrients essential for its growth. However, to reveal the extent to which such therapies actually conquer the tumour we need to measure blood flow in the tumour vessels.... Read more »
Brunker J, & Beard P. (2012) Pulsed photoacoustic Doppler flowmetry using time-domain cross-correlation: accuracy, resolution and scalability. The Journal of the Acoustical Society of America, 132(3), 1780-91. PMID: 22978905
Religions tend to evolve and adapt to benefit a society the most. The first religion can be uncovered from ancient anthropomorphic sculptures 42,000 years ago.... Read more »
WU Fei-fei,JIN Li-ji,LI Xiao-yu,LI Hua-qiang,CAO Zhen-hui,YOU Jian-song,XU Yong-ping(Ministry of Education Center for Food Safety of Animal Origin,College of Life Science and Technology, Dalian University of Technology,Dalian 116024,China). (2012) Research progress in active ingredients and pharmacological effects of deer antler. Chinese Journal. info:/
Q: Why don’t I write much about nutrition? A: I barely believe anything I read about it. After spending the last decade with my head in the ‘health and fitness’ industry, I’ve developed a healthy skepticism – literally. It’s probably because I’ve seen so many fads come and go, myths busted, and contradictory research. Now, I take most of what I read with a grain of salt – and I’m probably healthier because of it.
Here’s why:... Read more »
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, & Gluud C. (2012) Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane database of systematic reviews (Online). PMID: 22419320
Smith-Spangler C, Brandeau ML, Hunter GE, Bavinger JC, Pearson M, Eschbach PJ, Sundaram V, Liu H, Schirmer P, Stave C.... (2012) Are organic foods safer or healthier than conventional alternatives?: a systematic review. Annals of internal medicine, 157(5), 348-66. PMID: 22944875
Nothing is certain, but blood pressure does increase in the end of winter and beginning of spring. According to Aurametrix users and google statistics. As a matter of fact, it highly correlates with tax fever - as found by Google Correlate algorithm comparing millions of web queries. But the reason for raising blood pressure is not always taxes.Â Seasonal variation in blood pressure was noticed and described more than 50 years agoÂ and was connected to periods of decreasing outdoor temperature. ........ Read more »
AlpĂ©rovitch, A. (2009) Relationship Between Blood Pressure and Outdoor Temperature in a Large Sample of Elderly IndividualsThe Three-City Study. Archives of Internal Medicine, 169(1), 75. DOI: 10.1001/archinternmed.2008.512
Halonen, J., Zanobetti, A., Sparrow, D., Vokonas, P., & Schwartz, J. (2010) Relationship between outdoor temperature and blood pressure. Occupational and Environmental Medicine, 68(4), 296-301. DOI: 10.1136/oem.2010.056507
Brook RD, Weder AB, & Rajagopalan S. (2011) "Environmental hypertensionology" the effects of environmental factors on blood pressure in clinical practice and research. Journal of clinical hypertension (Greenwich, Conn.), 13(11), 836-42. PMID: 22051429
I seem to have been focusing a lot on folic acid (vitamin B9) and vitamin B12 these days. It's not that I'm in anyway choosing the direction taken, it just happens that the published papers are appearing that way.And as if to prove my point, enter the paper by Joshua Roffman and colleagues* (open-access) reporting results from a gold-standard, randomised, double-blind, placebo-controlled study on the addition of folic acid and vitamin B12 supplement to antipsychotic medication for a group of adu........ Read more »
Roffman JL, Lamberti JS, Achtyes E, Macklin EA, Galendez GC, Raeke LH, Silverstein NJ, Smoller JW, Hill M, & Goff DC. (2013) Randomized Multicenter Investigation of Folate Plus Vitamin B12 Supplementation in Schizophrenia. JAMA psychiatry (Chicago, Ill.), 1-9. PMID: 23467813
The Journal of Strength and Conditioning Research is a good portal for the S&C coach. However, I keep reading articles in it that make me question its scientific rigour. I’ve already written about a recent paper in which a completely invalid methodology was used (although I must thank them for this as it was a great teaching tool). Now, they have published an article entitled “Changes in Height, Body Weight, and Body Composition in American Football Players From 1942 to 2011″.... Read more »
Anzell AR, Potteiger JA, Kraemer WJ, & Otieno S. (2013) Changes in height, body weight, and body composition in American football players from 1942 to 2011. Journal of strength and conditioning research / National Strength , 27(2), 277-84. PMID: 23222088
Two recent studies - the ominously named "fecal transplant" study and another on acne-causing bacteria - reinforce a compelling idea about our microbiomes that has been brewing for a few years: that some infectious diseases may be due in part to a disharmonious balance between pathogenic bad-guy bacteria and our resident commensal good-guy bacteria. ... Read more »
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E., de Vos, W., Visser, C., Kuijper, E., Bartelsman, J., Tijssen, J.... (2013) Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile. New England Journal of Medicine, 368(5), 407-415. DOI: 10.1056/NEJMoa1205037
Color coding allows smokers to easily identify their former brands.
The tobacco industry has once again made a mockery of the Food and Drug Administrationâs attempts to ban âlightâ cigarettes from the marketplace, by simply eliminated the objectionable wording and substituting an easily-decoded color scheme. In a brochure prepared for cigarette retailers marked âFor trade use only: not to be shown or distributed to customers,â tobacco giant Philip Morris wrote that âsome cigarett........ Read more »
Connolly Gregory N, & Alpert Hillel R. (2013) Has the tobacco industry evaded the FDA's ban on 'Light' cigarette descriptors?. Tobacco control. PMID: 23485704
Avid followers of the autism research circuit must have noticed the increasing tide of studies looking at a possible role for maternal immune activation (MIA) in relation to risk of offspring autism spectrum disorder (ASD). It's a topic I've covered more than once on this blog; predominantly in relation to the work of people like Paul Patterson and his colleagues (see here), observations on things like C-reactive protein (see here) and the various ways to experimentally mimic such MIA in the mou........ Read more »
Schwartzer JJ, Careaga M, Onore CE, Rushakoff JA, Berman RF, & Ashwood P. (2013) Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. Translational psychiatry. PMID: 23481627
Naviaux, R., Zolkipli, Z., Wang, L., Nakayama, T., Naviaux, J., Le, T., Schuchbauer, M., Rogac, M., Tang, Q., Dugan, L.... (2013) Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model. PLoS ONE, 8(3). DOI: 10.1371/journal.pone.0057380
Are you required to backboard a patient who was shot in the neck no matter how the patient is presenting? 
That is the entire question that was asked at The Paramedic’s Edge.
There are really several questions being asked.... Read more »
Stuke, L., Pons, P., Guy, J., Chapleau, W., Butler, F., & McSwain, N. (2011) Prehospital Spine Immobilization for Penetrating TraumaâReview and Recommendations From the Prehospital Trauma Life Support Executive Committee. The Journal of Trauma: Injury, Infection, and Critical Care, 71(3), 763-770. DOI: 10.1097/TA.0b013e3182255cb9
. (2001) The cause of neurologic deterioration after acute cervical spinal cord injury. Journal of Neurosurgical Anesthesiology, 13(3), 280-281. DOI: 10.1097/00008506-200107000-00022
A recent study on mice, baboons and few volunteering patients revealed that a non-steroidal anti-inflammatory drug (NSAID) called meloxicam increases significantly the number of hematopoietic stem cells entering the blood stream. The study can potentially help patients requiring a hematopoietic stem cell (HSC), most notably leukemia victims. The study was carried out by researchers, led by Louis Pelus, at Indiana University's School of MedicineFull Story... Read more »
Hoggatt, J., Mohammad, K., Singh, P., Hoggatt, A., Chitteti, B., Speth, J., Hu, P., Poteat, B., Stilger, K., Ferraro, F.... (2013) Differential stem- and progenitor-cell trafficking by prostaglandin E2. Nature. DOI: 10.1038/nature11929
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