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  • June 17, 2015
  • 01:33 PM
  • 78 views

Living Kidney Donors Experience 37 Heart Changes After Donation

by Cristy at Living Donor 101 in Living Donors Are People Too

You’ve heard me harp on this before. How a 10% reduction in kidney function significantly increases the risk of cardiovacular disease and death. How most people who are diagnosed in with early stage CKD (chronic kidney disease), GFR 60-80, will die of a cardiovascular event before progressing to kidney failure. How 26% of kidney failure …
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The post Living Kidney Donors Experience 37 Heart Changes After Donation appeared first on Living Donors Are People Too.
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Moody, W., Ferro, C., Edwards, N., Chue, C., Lin, E., Cockwell, P., Steeds, R., Townend, J., & Taylor, R. (2015) 37 Cardiovascular Effects of Unilateral Nephrectomy in Human Kidney Donors. Heart, 101(Suppl 4). DOI: 10.1136/heartjnl-2015-308066.37  

  • June 17, 2015
  • 05:02 AM
  • 147 views

Antipsychotic drugs as epigenetic modifiers?

by Paul Whiteley in Questioning Answers

The paper by Blaga Rukova and colleagues [1] (open-access available here) published last year (2014) caught my eye recently and their observations of: "major differences in methylation profiles between male schizophrenia patients in complete remission before and after treatment and healthy controls" as potential evidence that: "antipsychotic drugs may play a role in epigenetic modifications."The process of methylation, as in DNA methylation where methyl groups are added to specific segments........ Read more »

Rukova B, Staneva R, Hadjidekova S, Stamenov G, Milanova V, & Toncheva D. (2014) Whole genome methylation analyses of schizophrenia patients before and after treatment. Biotechnology, biotechnological equipment, 28(3), 518-524. PMID: 26019538  

  • June 16, 2015
  • 04:46 AM
  • 144 views

Gut bacteria and toddler temperament

by Paul Whiteley in Questioning Answers

The 'terrible twos'. Y'know, that special time in a child's development when the words 'mine' and 'no' are much more than a daily occurrence and visions of supermarket / restaurant meltdowns complete with scathing looks from strangers still linger in the rose-tinted memories of parenting.There's still quite a bit of debate about the hows and whys of the terrible twos but new research by Lisa Christian and colleagues [1] implicates a hitherto unappreciated system potentially at work: our gut........ Read more »

Christian LM, Galley JD, Hade EM, Schoppe-Sullivan S, Kamp Dush C, & Bailey MT. (2015) Gut microbiome composition is associated with temperament during early childhood. Brain, behavior, and immunity, 118-27. PMID: 25449582  

  • June 16, 2015
  • 04:46 AM
  • 121 views

Gut bacteria and toddler temperament

by Paul Whiteley in Questioning Answers

The 'terrible twos'. Y'know, that special time in a child's development when the words 'mine' and 'no' are much more than a daily occurrence and visions of supermarket / restaurant meltdowns complete with scathing looks from strangers still linger in the rose-tinted memories of parenting.There's still quite a bit of debate about the hows and whys of the terrible twos but new research by Lisa Christian and colleagues [1] implicates a hitherto unappreciated system potentially at work: our gut........ Read more »

Christian LM, Galley JD, Hade EM, Schoppe-Sullivan S, Kamp Dush C, & Bailey MT. (2015) Gut microbiome composition is associated with temperament during early childhood. Brain, behavior, and immunity, 118-27. PMID: 25449582  

  • June 15, 2015
  • 01:13 PM
  • 108 views

Avocados may hold the answer to beating leukemia

by Dr. Jekyll in Lunatic Laboratories

Rich, creamy, nutritious and now cancer fighting. New research reveals that molecules derived from avocados could be effective in treating a form of cancer. Professor Paul Spagnuolo from the University of Waterloo has discovered a lipid in avocados that combats acute myeloid leukemia (AML) by targeting the root of the disease – leukemia stem cells. Worldwide, there are few drug treatments available to patients that target leukemia stem cells.... Read more »

Lee, E., Angka, L., Rota, S., Hanlon, T., Mitchell, A., Hurren, R., Wang, X., Gronda, M., Boyaci, E., Bojko, B.... (2015) Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death. Cancer Research, 75(12), 2478-2488. DOI: 10.1158/0008-5472.CAN-14-2676  

  • June 15, 2015
  • 12:50 PM
  • 112 views

Loving to Death

by Miss Behavior in The Scorpion and the Frog

The brown antechinus may look like a mouse - but that is where the similarities end. Photo by Glen Fergus at Wikimedia.Although most animal species breed multiple times throughout their lives, a few oddballs put everything they've got into a single reproductive season, after which they promptly die. This is a rare strategy (for obvious reasons), especially in mammals. One Australian mammal, the brown antechinus, is just odd enough to pull it off.The brown antechinus is a small insectivorous mous........ Read more »

  • June 15, 2015
  • 06:09 AM
  • 104 views

Cancer Breakthrough: New Device May Revolutionize Treatment

by Agnese Mariotti in United Academics

Preclinical problems are solved as CIVO simultaneously injects eight drugs.... Read more »

Klinghoffer, R., Bahrami, S., Hatton, B., Frazier, J., Moreno-Gonzalez, A., Strand, A., Kerwin, W., Casalini, J., Thirstrup, D., You, S.... (2015) A technology platform to assess multiple cancer agents simultaneously within a patient's tumor. Science Translational Medicine, 7(284), 284-284. DOI: 10.1126/scitranslmed.aaa7489  

  • June 15, 2015
  • 04:53 AM
  • 145 views

Seeking out autism medical comorbidity clusters

by Paul Whiteley in Questioning Answers

I was rather interested in the findings reported by Kimberly Aldinger and colleagues [1] (open-access here) recently and an intriguing attempt to find out whether "there are predictive patterns of medical conditions that co-occur with ASD [autism spectrum disorder], which could inform medical evaluation and treatment in ASD, as well as potentially identify etiologically meaningful subgroups."Comorbidity (if I can still call it that) is of great interest to this blog and the idea that a........ Read more »

  • June 14, 2015
  • 03:23 PM
  • 115 views

Power of the media’s impact on medicine use revealed

by Dr. Jekyll in Lunatic Laboratories

More than 60,000 Australians are estimated to have reduced or discontinued their use of prescribed cholesterol-lowering statin medications following the airing of a two-part series critical of statins by ABC TV’s science program, Catalyst, a University of Sydney study reveals. The analysis of the Pharmaceutical Benefits Scheme medication records of 191,000 people revealed that there was an immediate impact after Catalyst was aired in October 2013, with 14,000 fewer people dispensed statins per........ Read more »

Schaffer, A., Buckley, N., Dobbins, T., Banks, E., & Pearson, S. (2015) The crux of the matter: Did the ABC's Catalyst program change statin use in Australia?. The Medical Journal of Australia, 202(11), 591-594. DOI: 10.5694/mja15.00103  

  • June 13, 2015
  • 01:44 PM
  • 120 views

Hormone that differentiates sugar, diet sweeteners could exist in humans

by Dr. Jekyll in Lunatic Laboratories

We’ve all been there: We eat an entire sleeve of fat-free, low-calorie cookies and we’re stuffing ourselves with more food 15 minutes later. One theory to explain this phenomenon is that artificial sweeteners don’t contain the calories or energy that evolution has trained the brain to expect from sweet-tasting foods, so they don’t fool the brain […]... Read more »

Monica Dus et al. (2015) Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila. Neuron. info:/10.1016/j.neuron.2015.05.032

  • June 13, 2015
  • 02:59 AM
  • 147 views

Autism, higher education and employment: what happens long-term?

by Paul Whiteley in Questioning Answers

Note: I wish I knew who to attribute this fantastic picture to.I want to draw your attention to the paper by Julie Lounds Taylor and colleagues [1] in today's post and some slightly worrying findings based on their longitudinal investigation of postsecondary (higher) education and employment experiences for a group of 73 adults diagnosed as being on the autism spectrum.To quote: "Although two-thirds of adults with autism spectrum disorder participated in competitive employment/postseco........ Read more »

  • June 12, 2015
  • 03:51 PM
  • 130 views

Cell density remains constant as brain shrinks with age

by Dr. Jekyll in Lunatic Laboratories

New, ultra-high-field magnetic resonance images (MRI) of the brain by researchers at the University of Illinois at Chicago provide the most detailed images to date to show that while the brain shrinks with age, brain cell density remains constant. The images provide the first evidence that in normal aging, cell density is preserved throughout the brain, not just in specific regions, as previous studies on human brain tissue have shown.... Read more »

  • June 12, 2015
  • 01:30 PM
  • 107 views

Autoimmunity: New immunoregulation and biomarker

by Dr. Jekyll in Lunatic Laboratories

Clinicians at Ludwig-Maximilians-Universitaet (LMU) in Munich have elucidated a mechanism involved in determining the lifespan of antibody-producing cells, and identified a promising new biomarker for monitoring autoimmune diseases like multiple sclerosis and lupus erythematosus.... Read more »

Laurent, S., Hoffmann, F., Kuhn, P., Cheng, Q., Chu, Y., Schmidt-Supprian, M., Hauck, S., Schuh, E., Krumbholz, M., Rübsamen, H.... (2015) γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nature Communications, 7333. DOI: 10.1038/ncomms8333  

  • June 12, 2015
  • 04:39 AM
  • 141 views

Infections and cognitive ability

by Paul Whiteley in Questioning Answers

Today I'm serving up the study findings reported by Michael Benrós and colleagues [1] (open-access) describing how: "Independent of a wide range of possible confounders, significant associations between infections and cognitive ability were observed" in their study of over 160,000 male conscripts during the years 2006–2012 who were tested for cognitive ability. Some further write-up of the study can also be found here.Using the Danish Conscription Registry (existing a........ Read more »

  • June 11, 2015
  • 03:12 PM
  • 120 views

Milk proteins may protect against cardiovascular disease

by Dr. Jekyll in Lunatic Laboratories

The Maillard reaction is a chemical reaction between amino acids and reducing sugars that results in browned foods like seared steaks and toasted bread. When proteins and sugars are mixed together and heated, new chemical compounds are formed. Some are responsible for new flavors and some, according to a new study, may protect us against cardiovascular disease.... Read more »

  • June 11, 2015
  • 05:11 AM
  • 153 views

Higher vitamin D = reduced risk of depression?

by Paul Whiteley in Questioning Answers

"These results support the hypothesis that higher serum 25(OH)D concentrations protect against depression even after adjustment for a large number of sociodemographic, lifestyle and metabolic factors."That was the conclusion reached by Tuija Jääskeläinen and colleagues [1] who analysed data from several thousands of people (men and women aged between 30 -79 years old) included as part of the Finnish Health 2000 survey. Alongside assaying for serum levels of 25(OH)D - 25-hydroxy vitamin D........ Read more »

Jääskeläinen T, Knekt P, Suvisaari J, Männistö S, Partonen T, Sääksjärvi K, Kaartinen NE, Kanerva N, & Lindfors O. (2015) Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression. The British journal of nutrition, 113(9), 1418-26. PMID: 25989997  

  • June 10, 2015
  • 06:15 PM
  • 121 views

New drug can clear all psoriasis symptoms

by Dr. Jekyll in Lunatic Laboratories

Good news for anyone who has psoriasis, a University of Manchester led trial of a new drug has resulted in 40 percent of people showing a complete clearance of psoriatic plaques after 12 weeks of treatment and over 90 percent showing improvement. The research tested 2,500 people with psoriasis. Half were given a new drug – ixekizumab – either once every two or four weeks. The other half were given a placebo or a widely used drug for psoriasis called etanercept.... Read more »

Prof Christopher E M, Griffiths, MD, Prof Kristian Reich, MD, Prof Mark Lebwohl, MD, Prof Peter van de Kerkhof, MD, Prof Carle Paul, MD, Alan Menter, MD, Gregory S Cameron, PhD, Janelle Erickson, PhD, Lu Zhang, MS.... (2015) Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials . Lancet. DOI: http://dx.org/10.1016/S0140-6736(15)60125-8  

  • June 10, 2015
  • 05:44 PM
  • 143 views

First functional, synthetic immune organ with controllable antibodies created by engineers

by Dr. Jekyll in Lunatic Laboratories

Cornell University engineers have created a functional, synthetic immune organ that produces antibodies and can be controlled in the lab, completely separate from a living organism. The engineered organ has implications for everything from rapid production of immune therapies to new frontiers in cancer or infectious disease research.... Read more »

Purwada, A., Jaiswal, M., Ahn, H., Nojima, T., Kitamura, D., Gaharwar, A., Cerchietti, L., & Singh, A. (2015) Ex vivo Engineered Immune Organoids for Controlled Germinal Center Reactions. Biomaterials. DOI: 10.1016/j.biomaterials.2015.06.002  

  • June 10, 2015
  • 12:58 PM
  • 135 views

Brain Default Network in Psychotic Bipolar Disorder

by William Yates, M.D. in Brain Posts

In a previous post I reviewed a summary of research related to genetics and improved diagnosis in bipolar disorder.One key point in this review was a highlight of the promise for integrating genetic with imaging research in bipolar disorder and other neuropsychiatric disorders.An example of this type of integrated research has been recently published in PNAS by a group of Yale University, the University of New Mexico and the University of Texas Southwestern Medical Center.This study used functio........ Read more »

Meda SA, Ruaño G, Windemuth A, O'Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E.... (2014) Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 111(19). PMID: 24778245  

  • June 10, 2015
  • 08:30 AM
  • 120 views

Hay Fever: Maladies, Melodies And Remedies

by Julia van Rensburg in The 'Scope

What the latest research says about allergies and your immune system. ... Read more »

Leb VM, Jahn-Schmid B, Schmetterer KG, Kueng HJ, Haiderer D, Neunkirchner A, Fischer GF, Nissler K, Hartl A, Thalhamer J.... (2008) Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes. The Journal of allergy and clinical immunology, 121(1), 64-71. PMID: 18037161  

Jahn-Schmid B, Hauser M, Wopfner N, Briza P, Berger UE, Asero R, Ebner C, Ferreira F, & Bohle B. (2012) Humoral and cellular cross-reactivity between Amb a 1, the major ragweed pollen allergen, and its mugwort homolog Art v 6. Journal of immunology (Baltimore, Md. : 1950), 188(3), 1559-67. PMID: 22205029  

Wopfner N, Bauer R, Thalhamer J, Ferreira F, & Chapman M. (2008) Immunologic analysis of monoclonal and immunoglobulin E antibody epitopes on natural and recombinant Amb a 1. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 38(1), 219-26. PMID: 18028463  

Asero R, Bellotto E, Ghiani A, Aina R, Villalta D, & Citterio S. (2014) Concomitant sensitization to ragweed and mugwort pollen: who is who in clinical allergy?. Annals of allergy, asthma , 113(3), 307-13. PMID: 25053399  

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