Mothers of children with autism and were diagnosed with metabolic conditions during pregnancy, particularly gestational and type 2 diabetes, were more likely to have anti-fetal brain autoantibodies in their blood compared to healthy women of children with autism. The presence of these anti-fetal brain autoantibodies has been previously found to be specific to some mothers of children with autism and rare among mothers of children without autism.
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Krakowiak, P., Walker, C., Tancredi, D., Hertz-Picciotto, I., & Van de Water, J. (2016) Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions. Autism Research. DOI: 10.1002/aur.1657
Scientists propose the creation of a synthetic human genome as a follow-up of the Human Genome Project... Read more »
Happy as a pig in...Assuming that I'm still around as and when published, I'd like to think that the final product of the study protocol from Elisa Santocchi and colleagues  will eventually find it's way on to this blog when the peer-reviewed results are finally in.Alongside it's ClinicalTrials.gov entry (see here), authors describe an interesting double-blind, placebo-controlled study where the aim is to "determine the effects of supplementation with a probiotic mixture (Vivomixx®) in ASD&n........ Read more »
Santocchi E, Guiducci L, Fulceri F, Billeci L, Buzzigoli E, Apicella F, Calderoni S, Grossi E, Morales MA, & Muratori F. (2016) Gut to brain interaction in Autism Spectrum Disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters. BMC psychiatry, 16(1), 183. PMID: 27260271
"Individuals with epilepsy are at increased risk of ASD [autism spectrum disorder], especially if epilepsy appears in childhood. Further, ASD is more common in the siblings and offspring of individuals with epilepsy, suggesting shared etiology."That was the research bottom-line from Heléne Sundelin and colleagues  reporting results based on examination of the "Swedish Patient Register" with regards to the "risk of autism spectrum disorder (ASD) in individuals with epilepsy and in t........ Read more »
Postpartum depression--a household term since actress Brooke Shields went public in 2005 about her struggle with it--is indeed serious. But depression that begins before or during pregnancy is often more severe because it lasts longer and usually goes undetected until the doctor screens for it after the birth of the baby.
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Fisher, S., Wisner, K., Clark, C., Sit, D., Luther, J., & Wisniewski, S. (2016) Factors associated with onset timing, symptoms, and severity of depression identified in the postpartum period. Journal of Affective Disorders, 111-120. DOI: 10.1016/j.jad.2016.05.063
"The prevalence of ID [intellectual disability] in WA [Western Australia] has increased over the past 10 years compared with previous estimates... This increase is associated in a large part with an increased prevalence of ASDs [autism spectrum disorder] for whom 70% had comorbid ID or an unknown level of ID."Those were some of the findings reported by Jenny Bourke and colleagues  (open-access available here). Drawing on data derived from the Intellectual Di........ Read more »
Bourke J, de Klerk N, Smith T, & Leonard H. (2016) Population-Based Prevalence of Intellectual Disability and Autism Spectrum Disorders in Western Australia: A Comparison With Previous Estimates. Medicine, 95(21). PMID: 27227936
As Breaking Bad has taught us, the clandestine manufacture of methamphetamine is a very dangerous undertaking. It involves the use of many harmful substances, which depending on the synthesis method include highly corrosive acids and bases, cancer-causing benzene, brain-damaging mercury and lead, jaw-wrecking phosphorus, and blood-breaking sodium cyanide. Blending these various substances together can produce noxious fumes, making gas masks and chemical suits a necessity if you want to avoid get........ Read more »
Cole C, Jones L, McVeigh J, Kicman A, Syed Q, & Bellis M. (2011) Adulterants in illicit drugs: A review of empirical evidence. Drug Testing and Analysis, 3(2), 89-96. PMID: 21322119
"The subsample that no longer fulfilled an autism spectrum disorder had full-time jobs or studies (10/11), independent living (100%), and reported having two or more friends (100%)."So said the paper by Adam Helles and colleagues  continuing a research theme from this authorship group on what happens to autism, or rather Asperger syndrome, in the longer-term (see here). Indeed, if you have the time, the thesis from Helles covering this area of study is well worth a read (see here).This time a........ Read more »
Helles A, Gillberg IC, Gillberg C, & Billstedt E. (2016) Asperger syndrome in males over two decades: Quality of life in relation to diagnostic stability and psychiatric comorbidity. Autism : the international journal of research and practice. PMID: 27233289
Stigma is a major barrier preventing people with mental health issues from getting the help they need. Even in a private and anonymous setting online, someone with greater self-stigma is less likely to take that first step to get information about mental health concerns and counseling.
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Lannin, D., Vogel, D., Brenner, R., Abraham, W., & Heath, P. (2016) Does self-stigma reduce the probability of seeking mental health information?. Journal of Counseling Psychology, 63(3), 351-358. DOI: 10.1037/cou0000108
My photo of Mozart No one denies the importance of public education. Raising graduation rates and academic ability in the general population are highly accepted education system goals. Additionally, identification of learning disorders and the barriers to academic progress are the focus of many.However, the study of the gifted is perhaps no less important but this topic receives less attention and research.Matthew Makel and colleagues at Duke University and Vanderbi........ Read more »
Makel MC, Kell HJ, Lubinski D, Putallaz M, & Benbow CP. (2016) When Lightning Strikes Twice: Profoundly Gifted, Profoundly Accomplished. Psychological science. PMID: 27225220
Kell HJ, Lubinski D, Benbow CP, & Steiger JH. (2013) Creativity and technical innovation: spatial ability's unique role. Psychological science, 24(9), 1831-6. PMID: 23846718
A small magnetic device might transform breast cancer surgeries... Read more »
Rahusen, F., Bremers, A., Fabry, H., Taets van Amerongen, A., Boom, R., & Meijer, S. (2002) Ultrasound-guided lumpectomy of nonpalpable breast cancer versus wire-guided resection: A randomized clinical trial. Annals of Surgical Oncology, 9(10), 994-998. DOI: 10.1007/BF02574518
Anderson, R., Kimmick, G., McCoy, T., Hopkins, J., Levine, E., Miller, G., Ribisl, P., & Mihalko, S. (2011) A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial. Journal of Cancer Survivorship, 6(2), 172-181. DOI: 10.1007/s11764-011-0208-4
Medina-Franco, H., Abarca-Pérez, L., García-Alvarez, M., Ulloa-Gómez, J., Romero-Trejo, C., & Sepúlveda-Méndez, J. (2008) Radioguided occult lesion localization (ROLL) versus wire-guided lumpectomy for non-palpable breast lesions: A randomized prospective evaluation. Journal of Surgical Oncology, 97(2), 108-111. DOI: 10.1002/jso.20880
Lovrics, P., Cornacchi, S., Vora, R., Goldsmith, C., & Kahnamoui, K. (2011) Systematic review of radioguided surgery for non-palpable breast cancer. European Journal of Surgical Oncology (EJSO), 37(5), 388-397. DOI: 10.1016/j.ejso.2011.01.018
Postma, E., Koffijberg, H., Verkooijen, H., Witkamp, A., van den Bosch, M., & van Hillegersberg, R. (2013) Cost-Effectiveness of Radioguided Occult Lesion Localization (ROLL) Versus Wire-Guided Localization (WGL) in Breast Conserving Surgery for Nonpalpable Breast Cancer: Results from a Randomized Controlled Multicenter Trial. Annals of Surgical Oncology, 20(7), 2219-2226. DOI: 10.1245/s10434-013-2888-7
Ahmed, M., & Douek, M. (2013) A systematic review and meta-analysis of intra-operative ultrasound versus wire-guided localization in the surgical management of non-palpable breast cancers. European Journal of Surgical Oncology (EJSO), 39(11). DOI: 10.1016/j.ejso.2013.07.212
"Children with ADHD [attention-deficit hyperactivity disorder] and ASD [autism spectrum disorder] had low levels of EPA [eicosapentaenoic acid], DHA [docosahexaenoic acid] and AA [arachidonic acid] and high ratio of n-6/n-3 PUFAs [polyunsaturated fatty acid] and these correlated significantly with symptoms. Future research should further investigate abnormal fatty acid metabolism in these disorders."So said the research publication by Natalie Par........ Read more »
Parletta N, Niyonsenga T, & Duff J. (2016) Omega-3 and Omega-6 Polyunsaturated Fatty Acid Levels and Correlations with Symptoms in Children with Attention Deficit Hyperactivity Disorder, Autistic Spectrum Disorder and Typically Developing Controls. PloS one, 11(5). PMID: 27232999
The May entry of "This Month in Blastocystis Research" focusses especially on the increasing interest in Blastocystis in a gut microbiota context. ... Read more »
Audebert C, Even G, Cian A, Blastocystis Investigation Group, Loywick A, Merlin S, Viscogliosi E, & Chabé M. (2016) Colonization with the enteric protozoa Blastocystis is associated with increased diversity of human gut bacterial microbiota. Scientific reports, 25255. PMID: 27147260
Andersen LO, Bonde I, Nielsen HB, & Stensvold CR. (2015) A retrospective metagenomics approach to studying Blastocystis. FEMS microbiology ecology, 91(7). PMID: 26130823
O'Brien Andersen L, Karim AB, Roager HM, Vigsnæs LK, Krogfelt KA, Licht TR, & Stensvold CR. (2016) Associations between common intestinal parasites and bacteria in humans as revealed by qPCR. European journal of clinical microbiology . PMID: 27230509
Ramírez JD, Sánchez A, Hernández C, Flórez C, Bernal MC, Giraldo JC, Reyes P, López MC, García L, Cooper PJ.... (2016) Geographic distribution of human Blastocystis subtypes in South America. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 32-5. PMID: 27034056
The antibiotic arms race is on, while we are rushing to find new antibiotics, bacteria are working on finding ways around them. With that in mind, a new experimental antibiotic developed by a team of scientists successfully treats the deadly MRSA infection and restores the efficacy of a commonly prescribed antibiotic that has become ineffective against MRSA.
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Kaul M, Mark L, Zhang Y, Parhi AK, Lyu YL, Pawlak J, Saravolatz S, Saravolatz LD, Weinstein MP, LaVoie EJ.... (2015) TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 59(8), 4845-55. PMID: 26033735
This post describes what Autoimmune diseases are. Part II will describe the potential of anti-cancer therapies as treatments for Autoimmune disease.... Read more »
Given my own research interest in the use of specific dietary modifications as possible intervention tools for some aspects of some autism (see here) I was more than interested to read the results published by Faezeh Ghalichi and colleagues  following their randomised-controlled trial of a gluten-free diet (GFD) including some 80 children diagnosed with an autism spectrum disorder (ASD).As part of an area of much discussion, debate and also heated argument down the years, the author........ Read more »
Ghalichi F, Ghaemmaghami J, Malek A, & Ostadrahimi A. (2016) Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial. World journal of pediatrics : WJP. PMID: 27286693
Human skin emits light (albeit the glow is extremely weak) and a wide variety of small molecules that may be sometimes "sniffed" by dogs or even other humans. These chemicals tell a story about our health and wellness, things we eat and drink, touch and breathe. Mosquitoes use such emissions to assess our "attractiveness" from indicators such as Indoles (unpleasantly smelling but healthy "inner soil" biomarker) or carbon dioxide (amount of which correlates with the size of the person........ Read more »
Andreoni G, Standoli CE, & Perego P. (2016) Defining Requirements and Related Methods for Designing Sensorized Garments. Sensors (Basel, Switzerland), 16(6). PMID: 27240361
Gao W, Emaminejad S, Nyein HY, Challa S, Chen K, Peck A, Fahad HM, Ota H, Shiraki H, Kiriya D.... (2016) Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature, 529(7587), 509-14. PMID: 26819044
Imani S, Bandodkar AJ, Mohan AM, Kumar R, Yu S, Wang J, & Mercier PP. (2016) A wearable chemical-electrophysiological hybrid biosensing system for real-time health and fitness monitoring. Nature communications, 11650. PMID: 27212140
Lee H, Choi TK, Lee YB, Cho HR, Ghaffari R, Wang L, Choi HJ, Chung TD, Lu N, Hyeon T.... (2016) A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy. Nature nanotechnology, 11(6), 566-72. PMID: 26999482
Panneer Selvam A, Muthukumar S, Kamakoti V, & Prasad S. (2016) A wearable biochemical sensor for monitoring alcohol consumption lifestyle through Ethyl glucuronide (EtG) detection in human sweat. Scientific reports, 23111. PMID: 26996103
Is copper deficiency contributing to the obesity epidemic? Though small amounts of copper are essential to health - oysters, liver, beans and nuts are good sources - copper's role in metabolism has been unclear: Some studies found that it boosted fat burning, others that it depressed it.
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I don't want to keep you today. Just long enough to draw your attention to the paper by Jones and colleagues  regarding "ongoing efforts toward identification of early biological markers specific to subphenotypes of ASD [autism spectrum disorder]."The potential biomarkers in question this time around were the cytokines/chemokines - those various signalling molecules that seem to have more than a few connections to important processes like inflammation - and how their profile ("mid-gestat........ Read more »
Jones KL, Croen LA, Yoshida CK, Heuer L, Hansen R, Zerbo O, DeLorenze GN, Kharrazi M, Yolken R, Ashwood P.... (2016) Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation. Molecular psychiatry. PMID: 27217154
Scientists have developed a powerful tool for exploring and determining the inherent biological differences between individuals, which overcomes a major hurdle for personalized medicine.
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