An alternative use for beer that will "get under your skin"!... Read more »
Chen, W., Becker, T., Qian, F., & Ring, J. (2014) Beer and beer compounds: physiological effects on skin health. Journal of the European Academy of Dermatology and Venereology, 28(2), 142-150. DOI: 10.1111/jdv.12204
Prof. Mancini computationally models HIV and other viruses’ dynamics and explains its clinical relevance.... Read more »
Mancini, E., Castiglione, F., Bernaschi, M., de Luca, A., & Sloot, P. (2012) HIV Reservoirs and Immune Surveillance Evasion Cause the Failure of Structured Treatment Interruptions: A Computational Study. PLoS ONE, 7(4). DOI: 10.1371/journal.pone.0036108
A micropost if you will, to bring to your attention the paper by Marco Sarno and colleagues  and their suggestion of "a novel effect of probiotics in the prevention of undigested gliadin peptides toxic effects".Knitting on't Moors @ Wikipedia The probiotic in question is something called Lactobacillus paracasei CBA L74, which if I'm not mistaken is connected with a certain '57 varieties' company. The authors (which included one Alessio Fasano) indicated that said probiotic appe........ Read more »
Sarno M, Lania G, Cuomo M, Nigro F, Passannanti F, Budelli A, Fasano F, Troncone R, Auricchio S, Barone MV.... (2014) Lactobacillus paracasei CBA L74 interferes with gliadin peptides entrance in Caco-2 cells. International journal of food sciences and nutrition, 1-7. PMID: 25030417
This study is interesting for several reasons.
In a system that claims excellence, the most consistent way to identify the study group is by documentation of a protocol violation - but it is not intended as a study of protocol violations.
This may hint at some benefit from epinephrine (Adrenaline in Commonwealth countries), but that would require some study and we just don't study epinephrine. We only make excuses for not studying epinephrine.
The atropine results suggest that the ........ Read more »
Roberts, J. (2011) InFocus: Dissecting the ACLS Guidelines on Cardiac Arrest from Toxic Ingestions. Emergency Medicine News, 33(10), 16-18. DOI: 10.1097/01.EEM.0000406945.05619.ca
Koller, A., Salcido, D., Callaway, C., & Menegazzi, J. (2014) Resuscitation characteristics and outcomes in suspected drug overdose-related out-of-hospital cardiac arrest. Resuscitation. DOI: 10.1016/j.resuscitation.2014.05.036
Fast food, let’s face it, it’s not the best for you. Yet Mcdonalds and Pizza hut are known practically world wide [although menu options differ]. With the rise of our […]... Read more »
Long L, Toda C, Jeong JK, Horvath TL, & Diano S. (2014) PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding. The Journal of clinical investigation. PMID: 25083994
It has been documented that there has been a rise in Autism Spectrum Disorder (ASD) in the United States, and that a large cause of this is due to redefinition of the disorder in the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-V) and an increased familiarization among psychiatrists and psychologists; but there is an unexplained portion of the increase. Studies have shown that parental age, namely maternal age can confer a higher risk for ASD. With the rise of paren........ Read more »
Shelton, J., Tancredi, D., & Hertz-Picciotto, I. (2010) Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Research. DOI: 10.1002/aur.116
Idring, S., Magnusson, C., Lundberg, M., Ek, M., Rai, D., Svensson, A., Dalman, C., Karlsson, H., & Lee, B. (2014) Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort. International Journal of Epidemiology, 43(1), 107-115. DOI: 10.1093/ije/dyt262
Like spicy food? Well next time you eat some you should hug that chili pepper, because he might just save your life. This is an interesting find, researchers have found that […]... Read more »
de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J.... (2014) Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. The Journal of clinical investigation. PMID: 25083990
Parkinson’s disease affects neurons in a particular brain region, when it develops brain cells have their mitochondrial activity cease and then the cells die. But now researchers have shown that supplying D-lactate […]... Read more »
Toyoda Y, Erkut C, Pan-Montojo F, Boland S, Stewart MP, Müller DJ, Wurst W, Hyman AA, & Kurzchalia TV. (2014) Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival. Biology open. PMID: 25063200
What makes Drosophila melanogaster (fruit flies) a good model organism for research? A general overview of fruit flies and some important papers demonstrating their relevance to human health.... Read more »
Valente EM, Salvi S, Ialongo T, Marongiu R, Elia AE, Caputo V, Romito L, Albanese A, Dallapiccola B, & Bentivoglio AR. (2004) PINK1 mutations are associated with sporadic early-onset parkinsonism. Annals of neurology, 56(3), 336-41. PMID: 15349860
Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF.... (2000) The genome sequence of Drosophila melanogaster. Science (New York, N.Y.), 287(5461), 2185-95. PMID: 10731132
Reiter LT, Potocki L, Chien S, Gribskov M, & Bier E. (2001) A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome research, 11(6), 1114-25. PMID: 11381037
Lloyd TE, & Taylor JP. (2010) Flightless flies: Drosophila models of neuromuscular disease. Annals of the New York Academy of Sciences. PMID: 20329357
Five of the coolest science news stories of the week! Friends & DNA, Alzheimer’s, a satanic gecko, fist bumps, and political brains... Read more »
Hibbing, J., Smith, K., & Alford, J. (2014) Differences in negativity bias underlie variations in political ideology. Behavioral and Brain Sciences, 37(03), 297-307. DOI: 10.1017/S0140525X13001192
Tumours are incredibly heterogeneic- that is that they have different properties including morphology (how they look), metabolism (the processes they use to generate energy), proliferation (how fast they grow, divide and replicate themselves) and potential to metastasise (where a tumour moves to another part of the body). But why is this so?
Many people are under the assumption that a cancer will arise from a single mutation in the DNA, but this is not actually the case. For a cancer to dev........ Read more »
Lo, Y., Corbetta, N., Chamberlain, P., Rai, V., Sargent, I., Redman, C., & Wainscoat, J. (1997) Presence of fetal DNA in maternal plasma and serum. The Lancet, 350(9076), 485-487. DOI: 10.1016/S0140-6736(97)02174-0
Vasioukhin V, Anker P, Maurice P, Lyautey J, Lederrey C, & Stroun M. (1994) Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia. British journal of haematology, 86(4), 774-9. PMID: 7918071
De Mattos-Arruda L, Weigelt B, Cortes J, Won HH, Ng CK, Nuciforo P, Bidard FC, Aura C, Saura C, Peg V.... (2014) Capturing Intra-Tumor Genetic Heterogeneity by De Novo Mutation Profiling of Circulating Cell-Free Tumor DNA: A Proof-of-Principle. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. PMID: 25009010
Pantel K, & Alix-Panabières C. (2013) Real-time liquid biopsy in cancer patients: fact or fiction?. Cancer research, 73(21), 6384-8. PMID: 24145355
Today I'm bringing to your attention the paper by Eva Troyb and colleagues  and the quite dramatic assertion: "Reports of current behavior indicated that RRB's [restricted and repetitive behaviors] had almost totally disappeared in the OO [optimal outcomes] group". RRBs just in case you might not know include quite an array of behaviours, some of which might not be considered 'disabling' such as the presence of certain circumscribed interests. Others, such as an insistence........ Read more »
Troyb E, Orinstein A, Tyson K, Eigsti IM, Naigles L, & Fein D. (2014) Restricted and Repetitive Behaviors in Individuals with a History of ASDs Who Have Achieved Optimal Outcomes. Journal of autism and developmental disorders. PMID: 25030967
This happens many times every day. A patient falls and may have hit her head, but there is no change from her normal mental status. To complicate matter, she takes an anticoagulant.
There are no clear signs of serious trauma. so should we automatically go to the trauma center?
What can help us decide?... Read more »
Hamden K, Agresti D, Jeanmonod R, Woods D, Reiter M, & Jeanmonod D. (2014) Characteristics of elderly fall patients with baseline mental status: high-risk features for intracranial injury. The American journal of emergency medicine. PMID: 24929771
Although the words “anorexia nervosa” typically conjure up images of emaciated bodies, eating disorders characterized by dietary restriction or weight loss can — and do — occur at any weight. However, precisely because anorexia nervosa is associated with underweight, doctors are less likely to identify eating disorders among individuals who are in the so-called “normal” or above normal weight range, even if they have........ Read more »
Lebow, J., Sim, L., & Kransdorf, L. (2014) Prevalence of a History of Overweight and Obesity in Adolescents With Restrictive Eating Disorders. Journal of Adolescent Health. DOI: 10.1016/j.jadohealth.2014.06.005
I’m sure you can all relate, you go to fix the sink and in the process you build a new kitchen on accident. Anyone… no? Well that is sort of […]... Read more »
Lisanti, S., Tavecchio, M., Chae, Y., Liu, Q., Brice, A., Thakur, M., Languino, L., & Altieri, D. (2014) Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks. Cell Reports. DOI: 10.1016/j.celrep.2014.06.061
Serum levels of dipeptidyl peptidase (DPP) IV were found to be lower in children with autism compared to asymptomatic controls according to the study by Shahid Bashira & Laila AL-Ayadhi . Based on analysis by ELISA, researchers concluded that "alterations in the plasma level of DPP IV play a role in the pathophysiology of autism".A sailor went to sea, sea, sea... @ Wikipedia Anyone who has followed the autism research scene for any length of time might have already heard ab........ Read more »
Bashir, S., & AL-Ayadhi, L. (2014) Alterations in plasma dipeptidyl peptidase IV in autism: A pilot study. Neurology, Psychiatry and Brain Research, 20(2), 41-44. DOI: 10.1016/j.npbr.2014.03.001
If you’ve been watching the news recently, you’ll probably have seen reports on the Ebola outbreak in West Africa. Around 673 people in Guinea and Liberia have died so far (including one case of a Liberian government employee who died shortly after arriving at Lagos airport in Nigeria), making this the most deadly outbreak to date. So what exactly is Ebola, and why is it so deadly?
Ebola virus disease (EVD) has an incredibly high mortality rate – while the current outbreak h........ Read more »
Gatherer, D. (2014) The 2014 Ebola virus disease outbreak in West Africa. Journal of General Virology, 95(Pt_8), 1619-1624. DOI: 10.1099/vir.0.067199-0
I tried to kill myself, more than once in fact. It was a troubling time for me and as a former active duty Marine that might not be too surprising […]... Read more »
Guintivano, J., Brown, T., Newcomer, A., Jones, M., Cox, O., Maher, B., Eaton, W., Payne, J., Wilcox, H., & Kaminsky, Z. (2014) Identification and Replication of a Combined Epigenetic and Genetic Biomarker Predicting Suicide and Suicidal Behaviors. American Journal of Psychiatry. DOI: 10.1176/appi.ajp.2014.14010008
Guintivano, J., Arad, M., Gould, T., Payne, J., & Kaminsky, Z. (2013) Antenatal prediction of postpartum depression with blood DNA methylation biomarkers. Molecular Psychiatry, 19(5), 560-567. DOI: 10.1038/mp.2013.62
Anecdotal reports have linked traumatic brain injury with later violent death including death by suicide.Few large epidemiological studies have been published on this association.However, a recent Swedish population study published in JAMA Psychiatry provides valuable insight into this issue.Seena Fazel and colleagues from the University of Oxford, University College London and the Karolinksa Institute examined a large database of over 200,000 patients with TBI.Cases of TBI were identified from ........ Read more »
Fazel S, Wolf A, Pillas D, Lichtenstein P, & Långström N. (2014) Suicide, fatal injuries, and other causes of premature mortality in patients with traumatic brain injury: a 41-year Swedish population study. JAMA psychiatry, 71(3), 326-33. PMID: 24430827
The Great War helped create the influenza pandemic of 1918, which eventually brought an early end to the Great War. Continue reading...... Read more »
Gamblin S. J. (2004) The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin. Science, 303(5665), 1838-1842. DOI: http://dx.doi.org/10.1126/science.1093155
Barry John M. (2004) The site of origin of the 1918 influenza pandemic and its public health implications (Commentary). Journal of Translational Medicine, 2(3). DOI: 10.1186/1479-5876-2-3
Humphries M. O. (2014) Paths of Infection: The First World War and the Origins of the 1918 Influenza Pandemic. War in History, 21(1), 55-81. DOI: http://dx.doi.org/10.1177/0968344513504525
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