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  • August 17, 2014
  • 02:36 PM
  • 118 views

Schizophrenia and the Twilight Zone

by Gabriel in Lunatic Laboratories

You are now entering the Twilight Zone. You may remember the television show, with it’s odd twists and turns, but for people with schizophrenia it means something just a little […]... Read more »

  • August 17, 2014
  • 11:26 AM
  • 100 views

A mosaic vaccine that could potentially protect from different ebola strains

by EE Giorgi in CHIMERAS

Disclaimer: The mosaic vaccine paper discussed in this article is from my own group and overlaps with some of the research I do. I'm sure you've been following the latest news about the Ebola virus outbreak in Africa."The Ebola outbreak in West Africa is the world's deadliest to date and the World Health Organization has declared an international health emergency as more than 1,000 people have died of the virus in Guinea, Liberia, Sierra Leone and Nigeria this year." [Source: BBC News]The e........ Read more »

Friedrich BM, Trefry JC, Biggins JE, Hensley LE, Honko AN, Smith DR, & Olinger GG. (2012) Potential vaccines and post-exposure treatments for filovirus infections. Viruses, 4(9), 1619-50. PMID: 23170176  

Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD.... (2007) Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nature medicine, 13(1), 100-6. PMID: 17187074  

  • August 16, 2014
  • 01:00 PM
  • 137 views

Is your Stomach… Controlling your Mind?

by Gabriel in Lunatic Laboratories

Close the blinds, lock the doors, and find a safe place to hide. Are you alone? No, no you aren’t and you may not even be in control of your […]... Read more »

  • August 16, 2014
  • 09:14 AM
  • 24 views

High Sugar & Plants

by Viputheshwar Sitaraman in Draw Science

Activating PPARy can cure high blood sugar, but the problem is that current treatment has serious side effects. Accordingly, we turn to plants and natural medicine to provide new chemical formulas for PPARy agonists to help cure hyperglycemia.... Read more »

Wang L, Waltenberger B, Pferschy-Wenzig EM, Blunder M, Liu X, Malainer C, Blazevic T, Schwaiger S, Rollinger JM, Heiss EH.... (2014) Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochemical pharmacology. PMID: 25083916  

  • August 16, 2014
  • 03:21 AM
  • 115 views

The epidemiology of autism spectrum disorders

by Paul Whiteley in Questioning Answers

A very short post for readers to ponder based on the paper by Amanda Baxter and colleagues [1] who talked about the global epidemiology of the autism spectrum disorders (ASDs)."In 2010 there were an estimated 52 million cases of ASDs, equating to a prevalence of 7.6 per 1000 or one in 132 persons".Aside from emphasising the word 'estimated' (I highlighted that), be prepared to see the Baxter paper and that quote cited quite a bit in the peer-reviewed literature in times to come.----------[1........ Read more »

A. J. Baxter, T. S. Brugha, H. E. Erskine, R. W. Scheurer, T. Vos, & J. G. Scott. (2014) The epidemiology and global burden of autism spectrum disorders. Psychological Medicine. info:/http://dx.doi.org/10.1017/S003329171400172X

  • August 15, 2014
  • 06:49 PM
  • 107 views

A non-invasive system to replace EEG/EMG recording of sleep

by Allison in Dormivigilia

Researchers highlight a new system that is ideal for high-throughput (large numbers of animals) studies for recording sleep. A game changer for sure. ... Read more »

  • August 15, 2014
  • 01:29 PM
  • 113 views

Swamp Thing and Plant Communication

by Gabriel in Lunatic Laboratories

Maybe I’m dating myself here, but ever see the swamp thing movie, television show, or even the comic? Call me picky, after all we are talking about a human/plant hybrid, but he never needed to talk. I know, some of you are probably rolling your eyes at me given it’s a comic, movie or tv show [depending on your level of geek], but come on, this is science![…]... Read more »

G. Kim,, M. L. LeBlanc,, E. K. Wafula,, C. W. dePamphilis,, & J. H. Westwood. (2014) Genomic-scale exchange of mRNA between a parasitic plant and its hosts. Science. info:/10.1126/science.1253122

  • August 15, 2014
  • 11:34 AM
  • 81 views

Breaking research: A new technique for uncovering cell-specific differences in the Drosophila “interactome”

by Bethany Christmann in Fly on the Wall

A recently published fly paper describes a new technique for uncovering cell-specific differences in protein interactions. I review this paper and discuss its relevance to human health.... Read more »

  • August 15, 2014
  • 04:07 AM
  • 109 views

Psychotic experience following childhood neurodevelopmental diagnosis

by Paul Whiteley in Questioning Answers

The paper by Golam Khandaker and colleagues [1] suggesting a higher risk of psychotic episodes (PEs) in early adolescence among those with a diagnosed childhood neurodevelopmental disorder (ND) makes for some interesting reading. Detailing several diagnoses as falling under the banner of neurodevelopmental disorder (autism spectrum, dyslexia, dyspraxia, dysgraphia, dysorthographia, dyscalculia), researchers concluded that: "The risk of PEs was higher in those with, compared with those witho........ Read more »

  • August 14, 2014
  • 03:35 PM
  • 150 views

Bringing the Fight to hidden HIV

by Gabriel in Lunatic Laboratories

We’ve got even more news for the HIV cure front. Yesterday we talked about broadly neutralizing antibodies, today we are going to be touching on that yet again,so if you […]... Read more »

Ariel Halper-Stromberg, Ching-Lan Lu, Florian Klein, Joshua A. Horwitz, Stylianos Bournazos, Lilian Nogueira, Thomas R. Eisenreich, Cassie Liu, Anna Gazumyan, Uwe Schaefer, Rebecca C. Furze, Michael S. Seaman.... (2014) Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice. Cell. info:/10.1016/j.cell.2014.07.043

  • August 14, 2014
  • 02:00 PM
  • 143 views

Dying To Make Us Laugh

by Mark E. Lasbury in The 'Scope

Robin William’s suicide was a tragic, but all too familiar happening amongst humorists of this period. New research is showing that comedians, performers in the arts, and even people with better senses of humor are prone to more health problems as adults. Depression , cardiovascular, pulmonary and stress related problem are not uncommon in comedians, and even children and adults that have better sense of humor are susceptible to obesity and cardiovascular disease.

The irony is that t........ Read more »

C.R. Epstein, R.J. Epstein. (2013) Death in The New York Times: the price of fame is a faster flame . QJM: monthly journal of the Association of Physicians, 106(6), 517-521. info:/

Greengross G. (2013) Humor and aging - a mini-review. Gerontology, 59(5), 448-53. PMID: 23689078  

Bennett MP, & Lengacher C. (2009) Humor and Laughter May Influence Health IV. Humor and Immune Function. Evidence-based complementary and alternative medicine : eCAM, 6(2), 159-64. PMID: 18955287  

  • August 14, 2014
  • 12:10 PM
  • 115 views

HIV Vaccine One Step Closer to Reality

by Gabriel in Lunatic Laboratories

The war on HIV, that tricky little guy has avoided every thing we could throw at it in a broad sense. Sure a few people here and there get lucky, but we have yet to actually make any sort of we're going to kick your ass headway [don't worry it's the technical term for it]. That is hopefully going to change with a new scientific discovery that has enormous implications for HIV vaccine development. Researchers have uncovered novel properties of special HIV antibodies that promise to........ Read more »

  • August 14, 2014
  • 11:17 AM
  • 97 views

FDA Approves Novel Insomnia Drug Suvorexant (Belsomra)

by William Yates, M.D. in Brain Posts

Regular readers of this blog had a heads up last year on the development of orexin receptor antagonists for the treatment of insomnia.I posted a review of an Italian clinical drug trial in humans with insomnia paired with polysomnography. This study used three different doses of a orexin receptor antagonist (10 mg 30 mg and 60 mg).In a second post, I reviewed a sleep lab study of the effects of an orexin antagonist drug compared to zolpidem (Ambien) on sleep architecture.This second study found ........ Read more »

  • August 14, 2014
  • 04:09 AM
  • 104 views

Learning disability in autism: how prevalent is it?

by Paul Whiteley in Questioning Answers

"Results showed that 36.8 % of the children met the criteria for ID [intellectual disability], with 60.2 % of these in the mild range (IQ 50-69) and 39.8 % in the moderate range (IQ 35-49)".That was the finding reported by Mélina Rivard and colleagues [1] looking at the co-occurrence of intellectual disability (also called learning disability here in Blighty) and autism spectrum disorder (ASD) "in young children". Based on an analysis of over 200 children diagnosed with an ASD, resear........ Read more »

  • August 13, 2014
  • 11:35 PM
  • 88 views

The Controversy of Admitting 'We Do Not Know What Works'

by Rogue Medic in Rogue Medic

There are several news articles today criticizing a study because the patients might be deprived of a drug that has not been adequately studied in humans. This criticism is coming from journalists – the people who publicized the fraudulent vaccines research by Andrew Wakefield, who was trying to sell his competing vaccine and was being paid to produce negative research by lawyers suing the vaccine companies.[1]

The real controversy is that this untested drug became the standard of care ........ Read more »

Larabee TM, Liu KY, Campbell JA, & Little CM. (2012) Vasopressors in cardiac arrest: a systematic review. Resuscitation, 83(8), 932-9. PMID: 22425731  

Herlitz J, Ekström L, Wennerblom B, Axelsson A, Bång A, & Holmberg S. (1995) Adrenaline in out-of-hospital ventricular fibrillation. Does it make any difference?. Resuscitation, 29(3), 195-201. PMID: 7667549  

Olasveengen, T., Sunde, K., Brunborg, C., Thowsen, J., Steen, P., & Wik, L. (2009) Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest: A Randomized Trial. JAMA: The Journal of the American Medical Association, 302(20), 2222-2229. DOI: 10.1001/jama.2009.1729  

Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, & Miyazaki S. (2012) Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA : the journal of the American Medical Association, 307(11), 1161-8. PMID: 22436956  

Hayashi Y, Iwami T, Kitamura T, Nishiuchi T, Kajino K, Sakai T, Nishiyama C, Nitta M, Hiraide A, & Kai T. (2012) Impact of early intravenous epinephrine administration on outcomes following out-of-hospital cardiac arrest. Circulation journal : official journal of the Japanese Circulation Society, 76(7), 1639-45. PMID: 22481099  

Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552  

Stiell IG, Hebert PC, Weitzman BN, Wells GA, Raman S, Stark RM, Higginson LA, Ahuja J, & Dickinson GE. (1992) High-dose epinephrine in adult cardiac arrest. The New England journal of medicine, 327(15), 1045-50. PMID: 1522840  

Callaway, C. (2012) Questioning the Use of Epinephrine to Treat Cardiac Arrest. JAMA: The Journal of the American Medical Association, 307(11), 1198. DOI: 10.1001/jama.2012.313  

  • August 13, 2014
  • 04:11 AM
  • 88 views

Neonatal intensive care unit (NICU) survivors and greater risk of autism?

by Paul Whiteley in Questioning Answers

"In term NICU [neonatal intensive care unit] survivors, ASD [autism spectrum disorder] occurs with a greater frequency than in the general population and often develops alongside comorbid conditions". That was the conclusion from the study by Alexander Winkler-Schwartz and colleagues [1] looking at term at-risk infants who survived NICU."You were only meant to blow the bloody doors off"'Surviving' their earliest days spent in NICU brings a bit of lump to my throat. As a paren........ Read more »

  • August 12, 2014
  • 02:07 PM
  • 104 views

Treatment and Prevention of PTSD

by Gabriel in Lunatic Laboratories

It’s no secret for anyone who follows me that I am a Marine veteran. It’s also no secret for anyone who follows me that I’ve had my own ups and downs in life because of my experiences. PTSD is a nightmare, one that you can’t quite shake no matter how hard you try. Then again, not everyone reacts the same way to the trauma that typically causes PTSD, not everyone walks away from war with it. The big question that scientists set out to answer was, why? And now they might just have an answe........ Read more »

Nikolaos P. Daskalakis, Hagit Cohen, Guiqing Caia, Joseph D. Buxbaum, & Rachel Yehuda. (2014) Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes. Proceedings of the National Academy of Sciences of the United States of America, 111(32). info:/10.1073/pnas.1401660111

  • August 12, 2014
  • 04:04 AM
  • 82 views

Neonatal jaundice and increased risk of ADHD

by Paul Whiteley in Questioning Answers

The findings from Chang-Ching Wei and colleagues [1] suggesting an over-representation of the diagnosis of attention-deficit hyperactivity disorder (ADHD) following a history of neonatal jaundice provides fodder for today's brief post. Based in Taiwan, one of the most impressive countries when it comes to the use and analysis of 'big data' (see here), researchers were able to identify some 25,000 participants diagnosed with neonatal jaundice and compare them with almost 70,000 non-jaundiced........ Read more »

  • August 11, 2014
  • 01:30 PM
  • 153 views

New Hope for Autoimmune Diseases

by Gabriel in Lunatic Laboratories

Autoimmune diseases are on the rise. Since I have a history of over sharing, my Uncle suffered from a form of lupus. It caused him intense and — in my opinion — unbearable pain although he shouldered it like the incredible man he was and never complained. My sister unfortunately is suffering from a rare disease that has yet to be diagnosed, which in my opinion has autoimmune dysfunction as the root cause. If you or anyone you know suffers in a similar fashion then you know that the treatment........ Read more »

Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK.... (2014) Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. PMID: 24891519  

  • August 11, 2014
  • 12:00 PM
  • 48 views

IT’S NEVER LUPUS? THINK AGAIN…

by Robb Hollis in Antisense Science

Those of you familiar with a certain misanthropic maverick MD will no doubt be familiar with the phrase “it’s never lupus”. Unfortunately, in the real world, it IS sometimes lupus – but what is lupus and how does it arise?
... Read more »

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