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  • July 11, 2014
  • 10:19 AM
  • 119 views

Epigenetics. Rat Tounges & Ham Sandwiches Can Influence Children (Part 1)

by The Lab Hippo in The Lab Hippo

There’s a concept in biology that has begun to break into mainstream culture that makes the mishmosh of genetics even more complicated. It’s called ‘epigenetics’, and it can explain how our environment, such as what we eat and breath, can influence our DNA. Biologists have known about epigenetics for some time, but it seems to have gained widespread traction lately largely due to findings that a mother can influence her unborn child’s DNA during pregnancy. This is called ‘intergenera........ Read more »

Rönn T, Volkov P, Davegårdh C, Dayeh T, Hall E, Olsson AH, Nilsson E, Tornberg A, Dekker Nitert M, Eriksson KF.... (2013) A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS genetics, 9(6). PMID: 23825961  

Weaver, I., Cervoni, N., Champagne, F., D'Alessio, A., Sharma, S., Seckl, J., Dymov, S., Szyf, M., & Meaney, M. (2004) Epigenetic programming by maternal behavior. Nature Neuroscience, 7(8), 847-854. DOI: 10.1038/nn1276  

  • July 11, 2014
  • 10:15 AM
  • 97 views

Can antioxidants accelerate cancer growth? Why you shouldn’t smoke and drink Vitamin Water

by The Lab Hippo in The Lab Hippo

Recently a paper was published that showed adding antioxidants, such as vitamin E, to the diet of mice accelerated the growth of lung tumors. This finding contradicts the commonly held belief that antioxidants act to protect us from cancer and other diseases.... Read more »

Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, & Bergo MO. (2014) Antioxidants accelerate lung cancer progression in mice. Science translational medicine, 6(221). PMID: 24477002  

  • July 11, 2014
  • 06:17 AM
  • 40 views

What ‘P.S. I Love You’ Taught Me About Blue Stress

by Samiiksha Rohilla in Workout Trends

Last evening, while watching people passing by my lane, I realized how lucky it is to be happy and alive. It wasn’t the same with me a few months back. I used to prefer staying alone. I had locked my guitar inside the cupboard. And I had quit my work. Was I in a state of […]
The post What ‘P.S. I Love You’ Taught Me About Blue Stress appeared first on .
... Read more »

  • July 11, 2014
  • 04:48 AM
  • 79 views

Maternal C-Reactive Protein (CRP) and offspring schizophrenia

by Paul Whiteley in Questioning Answers

A big quote to start this post: "This finding provides the most robust evidence to date that maternal inflammation may play a significant role in schizophrenia, with possible implications for identifying preventive strategies and pathogenic mechanisms in schizophrenia and other neurodevelopmental disorders".Ophelia @ Wikipedia The source for this quote was the paper by Sarah Canetta and colleagues [1] based on an analysis of serum samples from mums for C-reactive protein (CRP) as ........ Read more »

Canetta, S., Sourander, A., Surcel, H., Hinkka-Yli-Salomäki, S., Leiviskä, J., Kellendonk, C., McKeague, I., & Brown, A. (2014) Elevated Maternal C-Reactive Protein and Increased Risk of Schizophrenia in a National Birth Cohort. American Journal of Psychiatry. DOI: 10.1176/appi.ajp.2014.13121579  

  • July 11, 2014
  • 12:15 AM
  • 78 views

Remote CPR Skills Testing Online - A Crazy Idea?

by Rogue Medic in Rogue Medic

On the MedicCast, Jamie Davis interviews Roy Shaw of SUMO about a method of remote CPR certification for health care providers.

"The Single Use Manikin Option, or SUMO™, is an AHA-compliant way of getting certified in CPR completely online.[1]"

What different ways of dealing with certification/recertification problems should we use?... Read more »

Sutton RM, Niles D, Meaney PA, Aplenc R, French B, Abella BS, Lengetti EL, Berg RA, Helfaer MA, Nadkarni V. (2011) Low-Dose, High-Frequency CPR Training Improves Skill Retention of In-Hospital Pediatric Providers. PEDIATRICS, 128(1). DOI: 10.1542/peds.2010-2105d  

  • July 10, 2014
  • 01:59 PM
  • 118 views

Don’t Listen to the Voices: Understanding Consciousness

by Gabriel in Lunatic Laboratories

There is a voice in my head. Don't worry it's mine... I think [a story for another time I'm sure], but why is my voice inside my head? What causes me to hear myself while I type these very words, or even better you to hear them in your voice as you read them? Consciousness is a complex and very confusing thing. I think therefore I am? Science has had trouble cracking that nut and philosophy just won't cut it in the realm of neuroscience. [...]... Read more »

Paller, K., & Suzuki, S. (2014) The source of consciousness. Trends in Cognitive Sciences. DOI: 10.1016/j.tics.2014.05.012  

  • July 10, 2014
  • 03:34 AM
  • 89 views

Viral exposure and autism

by Paul Whiteley in Questioning Answers

A whole slew of articles published by Ivan Gentile and colleagues based at the University of Naples (Italy) brought me to writing this post looking at some of the literature on viral exposures and autism. Viruses, in case you didn't know, are some of nature's survivors, infecting host cells and reproducing, onwards hopeful of finding more (un)willing cells/organisms to infect. Humankind have developed various biological defence mechanisms against the viral (and bacterial) onslaught that we all f........ Read more »

Gentile I, Zappulo E, Bonavolta R, Maresca R, Messana T, Buonomo AR, Portella G, Sorrentino R, Settimi A, Pascotto A.... (2014) Prevalence and Titre of Antibodies to Cytomegalovirus and Epstein-Barr Virus in Patients with Autism Spectrum Disorder. In vivo (Athens, Greece), 28(4), 621-626. PMID: 24982232  

Gentile I, Zappulo E, Bonavolta R, Maresca R, Riccio MP, Buonomo AR, Portella G, Vallefuoco L, Settimi A, Pascotto A.... (2014) Prevalence of Herpes Simplex Virus 1 and 2 Antibodies in Patients with Autism Spectrum Disorders. In vivo (Athens, Greece), 28(4), 667-671. PMID: 24982239  

  • July 9, 2014
  • 01:37 PM
  • 110 views

Lose Weight, Live Longer. Simple, Right?

by Gabriel in Lunatic Laboratories

Suprise! Really this shouldn’t come as a shock, but adults with extreme obesity have increased risks of dying at a younger age from cancer and other complications like stroke, diabetes, heart disease, […]... Read more »

Kitahara, C., Flint, A., Berrington de Gonzalez, A., Bernstein, L., Brotzman, M., MacInnis, R., Moore, S., Robien, K., Rosenberg, P., Singh, P.... (2014) Association between Class III Obesity (BMI of 40–59 kg/m2) and Mortality: A Pooled Analysis of 20 Prospective Studies. PLoS Medicine, 11(7). DOI: 10.1371/journal.pmed.1001673  

  • July 9, 2014
  • 12:06 PM
  • 82 views

Brain Hippocampus Atrophy in Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Understanding the specific brain regions vulnerable to traumatic brain injury (TBI) is important for assessment and intervention research.Two areas of active research include studies of brain white matter using diffusion tensor imaging and assessment of regional brain atrophy using magnetic resonance imaging (MRI).Two recent MRI studies have suggested the brain hippocampus may be a region of vulnerability to TBI.A Canadian study by Robin Green and colleagues used brain MRI to examine a cohort of........ Read more »

Green RE, Colella B, Maller JJ, Bayley M, Glazer J, & Mikulis DJ. (2014) Scale and pattern of atrophy in the chronic stages of moderate-severe TBI. Frontiers in human neuroscience, 67. PMID: 24744712  

Singh R, Meier TB, Kuplicki R, Savitz J, Mukai I, Cavanagh L, Allen T, Teague TK, Nerio C, Polanski D.... (2014) Relationship of collegiate football experience and concussion with hippocampal volume and cognitive outcomes. JAMA : the journal of the American Medical Association, 311(18), 1883-8. PMID: 24825643  

  • July 9, 2014
  • 11:32 AM
  • 81 views

TCAS AS PAINKILLERS: PROOF THAT YOU CAN TEACH AN OLD DOG NEW TRICKS

by Emily Lawson in Antisense Science

The creation of a new drug that is safer, more effective, and has fewer side effects than the current treatment surely renders the current treatment obsolete, right? Well, not necessarily.

Take tricyclic antidepressants (TCAs) for instance. TCAs are a class of antidepressant that work by blocking the serotonin and noradrenaline transporters, leading to an increase in the amount of serotonin and noradrenaline in the synapse. As the current theory says that depression is caused by low levels of........ Read more »

Sindrup, S., Otto, M., Finnerup, N., & Jensen, T. (2005) Antidepressants in the Treatment of Neuropathic Pain. Basic Clinical Pharmacology Toxicology, 96(6), 399-409. DOI: 10.1111/j.1742-7843.2005.pto_96696601.x  

Bohren Y, Tessier LH, Megat S, Petitjean H, Hugel S, Daniel D, Kremer M, Fournel S, Hein L, Schlichter R.... (2013) Antidepressants suppress neuropathic pain by a peripheral β2-adrenoceptor mediated anti-TNFα mechanism. Neurobiology of disease, 39-50. PMID: 23978467  

Micó JA, Ardid D, Berrocoso E, & Eschalier A. (2006) Antidepressants and pain. Trends in pharmacological sciences, 27(7), 348-54. PMID: 16762426  

  • July 9, 2014
  • 09:21 AM
  • 112 views

A Deadly Shot: Heart Attacks During The World Cup

by Nura Rutten in United Academics

Studies show that there is an increase in cardiovascular events, such as heart attacks, at the time of important football matches like the World Cup. Especially penalty shoot-outs can cause a higher number of myocardial infarctions. However, there are also studies that report no significant influence or even a decrease in cardiac emergencies.... Read more »

Mendenhall, M., Ute Wilbert-Lampen, M.D.,, David Leistner, M.D.,, Sonja Greven, M.S.,, Tilmann Pohl, M.D.,, Sebastian Sper,, Christoph Völker,, Denise Güthlin,, Andrea Plasse,, Andreas Knez, M.D.,.... (2008) Cardiovascular Events During World Cup Soccer. The Journal of Emergency Medicine, 35(1), 114-115. DOI: 10.1016/j.jemermed.2008.03.028  

Carroll D, Ebrahim S, Tilling K, Macleod J, & Smith GD. (2002) Admissions for myocardial infarction and World Cup football: database survey. BMJ (Clinical research ed.), 325(7378), 1439-42. PMID: 12493655  

  • July 9, 2014
  • 08:15 AM
  • 97 views

What’s So Repelling About Repellents?

by Mark Lasbury in As Many Exceptions As Rules

It’s amazing that even though citronella and DEET reduce mosquito bites, we have very little idea of how they work. New research is showing that DEET interacts with olfactory receptors so that chemical attractants are still sensed, but their interpretations are confused. You are still there, but you pretty disappear as far as the mosquito is concerned. Other research shows that one of the co-receptors for olfactory receptors is responsible not only for DEET activity, but also for mosquito ........ Read more »

  • July 9, 2014
  • 05:52 AM
  • 76 views

Familial Recurrence of Autism Spectrum Disorder (again)

by Paul Whiteley in Questioning Answers

The paper by Neil Risch and colleagues [1] adds to the growing literature looking at the question of familial recurrence of autism i.e. if one child has a diagnosis of autism, how likely are subsequent children to be similarly diagnosed. The answer according to this latest data: "The overall sibling recurrence risk was 10.1%" compared with 0.5% in siblings of asymptomatic controls. This figure is pretty much the same as that reported by Sandin and colleagues [2] covered not so long ago (see here........ Read more »

  • July 8, 2014
  • 02:17 PM
  • 90 views

Skin Cells and Skin… smells?!

by Gabriel in Lunatic Laboratories

Yeah we all know that your nose smells. Yawn! Boring I know, this isn’t kindergarten this is Loony Labs! Thankfully that isn’t what I have for you [as much as […]... Read more »

Busse, D., Kudella, P., Grüning, N., Gisselmann, G., Ständer, S., Luger, T., Jacobsen, F., Steinsträßer, L., Paus, R., Gkogkolou, P.... (2014) A Synthetic Sandalwood Odorant Induces Wound Healing Processes in Human Keratinocytes via the Olfactory Receptor OR2AT4. Journal of Investigative Dermatology. DOI: 10.1038/jid.2014.273  

  • July 8, 2014
  • 11:15 AM
  • 75 views

Millions Lack Level I Trauma Care Access in the U.S.

by William Yates, M.D. in Brain Posts

Trauma results in 180,000 deaths per year in the U.S. and disproportionately affects children and young adults. The Centers for Disease Control (CDC) recently published a review highlighting unintentional injury and violence as the leading cause of death in the U.S. for those in the one to 30 year old age group. Additionally, trauma produces significant disability through residual effects such as like that often seen following traumatic brain injury.Trauma centers are hospital-affiliat........ Read more »

Haegerich, T., Dahlberg, L., Simon, T., Baldwin, G., Sleet, D., Greenspan, A., & Degutis, L. (2014) Prevention of injury and violence in the USA. The Lancet, 384(9937), 64-74. DOI: 10.1016/S0140-6736(14)60074-X  

Garwe T, Cowan LD, Neas B, Cathey T, Danford BC, & Greenawalt P. (2010) Survival benefit of transfer to tertiary trauma centers for major trauma patients initially presenting to nontertiary trauma centers. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(11), 1223-32. PMID: 21175521  

Bukur M, Felder SI, Singer MB, Ley EJ, Malinoski DJ, Margulies DR, & Salim A. (2013) Trauma center level impacts survival for cirrhotic trauma patients. The journal of trauma and acute care surgery, 74(4), 1133-7. PMID: 23511156  

MacKenzie, E., Weir, S., Rivara, F., Jurkovich, G., Nathens, A., Wang, W., Scharfstein, D., & Salkever, D. (2010) The Value of Trauma Center Care. The Journal of Trauma: Injury, Infection, and Critical Care, 69(1), 1-10. DOI: 10.1097/TA.0b013e3181e03a21  

  • July 8, 2014
  • 05:25 AM
  • 87 views

Coenzyme Q10 and autism

by Paul Whiteley in Questioning Answers

The paper by Frederick Crane and colleagues [1] (open-access here) caught my eye recently and their suggestion that when it comes to autism there may be more research to do on coenzyme Q10. Indeed, the old grey-pinkish matter started grinding into action as to whether there may be a wider research literature on CoQ10 with a focus on autism...A helping hand? @ Wikipedia Coenzyme Q10 otherwise known as ubiquinone, has appeared before on this blog for various reasons (see here and se........ Read more »

Crane FL, Löw H, Sun I, Navas P, & Gvozdjáková A. (2014) Plasma membrane coenzyme Q: evidence for a role in autism. Biologics : targets , 199-205. PMID: 24920882  

  • July 7, 2014
  • 11:27 PM
  • 81 views

The Refs are Biased, Neurologically

by Allison in Dormivigilia

During the last World Cup, a study was published that outlined why the human eye and human perception is fatly at certain angles. ... Read more »

Kranjec A, Lehet M, Bromberger B, Chatterjee A. (2010) A Sinister Bias for Calling Fouls in Soccer. PLoS One, 5(7). info:/10.1371/journal.pone.0011667

  • July 7, 2014
  • 04:09 PM
  • 106 views

Is there such a thing as an anti-depression diet?

by AB Kirk in Stiff Competition

Summary: People who suffer from depression seem to experience more oxidative stress and inflammation than others.  A diet high in anti-oxidants, fermentable fiber and low in saturated and transfats may protect against inflammatory stress in the brain and elsewhere.  More research needed.  The topic is under investigation. Introduction: We recently posted an article about the […]
The post Is there such a thing as an anti-depression diet? appeared first on WODMasters: Stiff Co........ Read more »

Moylan S, Berk M, Dean OM, Samuni Y, Williams LJ, O'Neil A, Hayley AC, Pasco JA, Anderson G, Jacka FN.... (2014) Oxidative . Neuroscience and biobehavioral reviews, 46-62. PMID: 24858007  

Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D.... (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature, 461(7268), 1282-6. PMID: 19865172  

Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, & Bruce-Keller AJ. (2010) Cognitive impairment following high fat diet consumption is associated with brain inflammation. Journal of neuroimmunology, 219(1-2), 25-32. PMID: 20004026  

  • July 7, 2014
  • 01:27 PM
  • 118 views

Staying up late? You’re going Crazy

by Gabriel in Lunatic Laboratories

All night cram sessions, anyone in college has probably had more than just a few of these [okay maybe only if you are a procrastinator like me]. If you have […]... Read more »

  • July 7, 2014
  • 10:50 AM
  • 81 views

The Geography of Traumatic Brain Injury Death in U.S.

by William Yates, M.D. in Brain Posts

In the last post, I examined some recent research in the epidemiology of traumatic brain injury (TBI).Two studies showed the top two causes of TBI to be motor vehicle crashes and falls.In this post, I will review some recent data on the geographic variability of TBI in the United States.The Centers for Disease Control provides an online tool called WISQARS that allows users to search for a variety of statistics related to unintentional injury by state in the U.S.They have recently added a iPad a........ Read more »

Centers for Disease Control and Prevention (CDC). (2013) CDC grand rounds: reducing severe traumatic brain injury in the United States. MMWR. Morbidity and mortality weekly report, 62(27), 549-52. PMID: 23842444  

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