It is a little known fact that some people are born with an immunity to HIV/AIDS. Such a person could be exposed to infection again and again and yet not contract the illness. They are the lucky ones. But more than that, they could also be the ones who hold the cure for the world. … Continue reading →... Read more »
Shimizu, S., Hong, P., Arumugam, B., Pokomo, L., Boyer, J., Koizumi, N., Kittipongdaja, P., Chen, A., Bristol, G., Galic, Z.... (2009) A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood, 115(8), 1534-1544. DOI: 10.1182/blood-2009-04-215855
Gaining weight is one of the most feared consequences to stopping smoking. So firstly, good on you for kicking the cigarettes. The majority of people will gain some weight after stopping smoking. On average, ex-smokers put on a couple of […]The post I gained two stone in weight since stopping smoking 10 months ago – why? appeared first on Guru Magazine.... Read more »
Aubin, H., Farley, A., Lycett, D., Lahmek, P., & Aveyard, P. (2012) Weight gain in smokers after quitting cigarettes: meta-analysis. BMJ, 345(jul10 2). DOI: 10.1136/bmj.e4439
Parsons AC, Shraim M, Inglis J, Aveyard P, & Hajek P. (2009) Interventions for preventing weight gain after smoking cessation. Cochraine Collaboration. DOI: 10.1002/14651858.CD006219.pub2
This is the second in series of posts examining recent research in sleep and the brain.Rapid eye movement (REM) sleep behavior disorder is a complex sleep problem seen primarily in older adults.REM, or dream sleep, typically occurs with atonia. Atonia is the temporary state of muscle paralysis. This prohibits muscular activity or acting out during dream states.With REM sleep behavior disorder, atonia is not present with REM sleep resulting in motor restlessness, agitation and occasio........ Read more »
Iranzo A, Fernández-Arcos A, Tolosa E, Serradell M, Molinuevo JL, Valldeoriola F, Gelpi E, Vilaseca I, Sánchez-Valle R, Lladó A.... (2014) Neurodegenerative Disorder Risk in Idiopathic REM Sleep Behavior Disorder: Study in 174 Patients. PloS one, 9(2). PMID: 24587002
“Two canine scientists, Julie Hecht and Mia Cobb, met briefly at a conference in Barcelona in late July 2012. They share a passion for canine science, good communication, social media and fun.” So reads the 'About' page at Do You Believe in Dog?. After a brief hello at the 3rd Canine Science Forum in Barcelona, we decided to embark on an adventure as digital pen pals, taking turns blogging on topics related to our own research, that of other research groups and general dog science themes.&n........ Read more »
Cobb Mia, Branson Nick, & McGreevy Paul. (2013) Advancing the welfare of Australia’s iconic working dogs. Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.054
Hecht J., & Horowitz A. (2013) Physical prompts to anthropomorphism of the domestic dog (Canis familiaris). Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.013
Racca A., Range F., Virányi Z., & Huber L. (2013) Discrimination of familiar human faces in domestic dogs. Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.071
Dreschel N.A., & Entendencia K. (2013) Stress during certification testing in prison drug detection dogs and their handlers. Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.005
MMRV is the quadruple vaccination against measles, mumps and rubella (MMR; more here) and chicken pox (also known as varicella). Varicella vaccination (developed in Japan) has been used in Japan for twenty years and in the USA since 1995. In 2006, the varicella vaccination was combined with MMR to make MMRV. MMRV was licensed in 2005 and is a routine vaccination in many countries including the USA, Germany and Australia. The advantages of this are to reduce the number of injections and therefore........ Read more »
Tarnjit Khera. (2014) MMR’s successor – MMRV. Scitkk.WordPress.com. info:other/
Benefits Sprinting and Jumping: New Evidence I began distance running at the age of 12 and have kept with it for decades now. Running at a mellow pace has helped me unwind, de-stress and keep my sanity through turbulent times. Until I started CrossFit about five years ago. While I miss the runners high there […]The post New Evidence on the Benefits of Sprinting for Long-Term Health and Fitness appeared first on WODMasters.... Read more »
Gast U, Belavý DL, Armbrecht G, Kusy K, Lexy H, Rawer R, Rittweger J, Winwood K, Zieliński J, & Felsenberg D. (2013) Bone density and neuromuscular function in older competitive athletes depend on running distance. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 24(7), 2033-42. PMID: 23242430
Not so long ago I talked about the paper from Smith and colleagues  on autism and obstacles to medical [comorbidity] diagnosis and treatment (see here). Aside from the need for professionals to overcome the issue of "a lack of expressive speech" as an impediment to undertaking a thorough medical work-up when presented with a person with autism, an important theme of that paper was the requirement to see beyond autism as being the 'reason' for every single behaviour or issue that aff........ Read more »
Tudor ME, Walsh CE, Mulder EC, & Lerner MD. (2014) Pain as a predictor of sleep problems in youth with autism spectrum disorders. Autism : the international journal of research and practice. PMID: 24497628
Do we do too many 12 lead ECGs on patients who do not have chest pain?
This is something that some people worry about.
Save the electrodes!
Those poor little electrodes are being abused!
Are electrodes being abused?... Read more »
Glickman SW, Shofer FS, Wu MC, Scholer MJ, Ndubuizu A, Peterson ED, Granger CB, Cairns CB, & Glickman LT. (2012) Development and validation of a prioritization rule for obtaining an immediate 12-lead electrocardiogram in the emergency department to identify ST-elevation myocardial infarction. American heart journal, 163(3), 372-82. PMID: 22424007
Few areas of biomedical research have benefited more from next-gen sequencing than studies of rare inherited diseases. Rapid, inexpensive exome sequencing in individuals with rare, presumably-monogenic diseases has been hugely successful over the past few years. There’s been a lot of discussion in the NGS community about the analysis burden of the large-scale whole-genome sequencing […]... Read more »
Koboldt DC, Larson DE, Sullivan LS, Bowne SJ, Steinberg KM, Churchill JD, Buhr AC, Nutter N, Pierce EA, Blanton SH.... (2014) Exome-Based Mapping and Variant Prioritization for Inherited Mendelian Disorders. American journal of human genetics. PMID: 24560519
This month I will be focusing on sleep and the brain. The importance of sleep to normal and abnormal brain functioning is receiving increased research attention.A variety of sleep abnormalities have been described in major depression and bipolar affective disorder. Depression has been linked to delayed sleep onset, reduced time to first rapid eye movement (REM) period, reduced sleep efficiency and disruption of the circadian rhythm of sleep.Sleep physiology also varies throughout the lifesp........ Read more »
Robillard, R., Naismith, S., Smith, K., Rogers, N., White, D., Terpening, Z., Ip, T., Hermens, D., Whitwell, B., Scott, E.... (2014) Sleep-Wake Cycle in Young and Older Persons with a Lifetime History of Mood Disorders. PLoS ONE, 9(2). DOI: 10.1371/journal.pone.0087763
Today I'm highlighting the paper by Krystle Graham and colleagues  which talked about a possible association between the presence of urinary tract infections (UTIs) in various types of psychosis. With my interest in all things biology-behaviour, remembering such posts as impulsivity and uric acid (see here), once again we have an example of how the two areas just might fit together.The bullfighter (deceased) @Manet @Wikipedia So, take several groups of adult........ Read more »
Prehistoric giant virus buried in the Siberian ice recovered from a scientific expedition. No, it is not the plot of “The Thing”, but the utter truth: a thirty- thousand- year old virus, whose dimensions are 50 times bigger than the ones of average virus from today, was found by Abergel and Claverie’s team in the Russian permafrost.... Read more »
Legendre M, Bartoli J, Shmakova L, Jeudy S, Labadie K, Adrait A, Lescot M, Poirot O, Bertaux L, Bruley C.... (2014) Thirty-thousand-year-old distant relative of giant icosahedral DNA viruses with a pandoravirus morphology. Proceedings of the National Academy of Sciences of the United States of America. PMID: 24591590
Philippe N, Legendre M, Doutre G, Couté Y, Poirot O, Lescot M, Arslan D, Seltzer V, Bertaux L, Bruley C.... (2013) Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of parasitic eukaryotes. Science (New York, N.Y.), 341(6143), 281-6. PMID: 23869018
That an early pregnancy is protective against breast cancer is something I've known for ten years now. I remember one of my professors, back when I started studying genetics, saying: "Having a baby at 16 may ruin your life but it sure protects you from breast cancer." Today we know a lot more about the cellular and genetic mechanisms that a first pregnancy triggers in the body. And yet how these mechanisms turn out to be protective against breast cancer is still a mystery. "The ovarian hormones,........ Read more »
Medina D. (2005) Mammary developmental fate and breast cancer risk. Endocrine-related cancer, 12(3), 483-95. PMID: 16172188
Meier-Abt F, & Bentires-Alj M. (2014) How pregnancy at early age protects against breast cancer. Trends in molecular medicine, 20(3), 143-153. PMID: 24355762
The paper by Michael Benrós and colleagues  talking about an "increased risk of subsequent autoimmune diseases in individuals with schizophrenia" caught my eye recently. Based on a trawl of the records of several thousands of people with "schizophrenia-like psychosis" or "individuals with autoimmune disease" derived from Danish nationwide registers (see here for some background), the authors were able to conclude that "Autoimmune diseases developed subsequently in 3.6% of people wi........ Read more »
Benrós ME, Pedersen MG, Rasmussen H, Eaton WW, Nordentoft M, & Mortensen PB. (2013) A Nationwide Study on the Risk of Autoimmune Diseases in Individuals With a Personal or a Family History of Schizophrenia and Related Psychosis. The American journal of psychiatry. PMID: 24129899
Patients in the Intensive Care Unit (ICU) often develop cognitive deficits. The symptoms are very similar to Alzheimer’s and other forms of dementia. New research focuses on this link. ... Read more »
Pandharipande PP1, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW; BRAIN-ICU Study Investigators. (2014) Long-Term Cognitive Impairment after Critical Illness. New England Journal of Medicine, 370(2), 184-186. DOI: 10.1056/NEJMc1313886
Bohannon, R., Maljanian, R., & Ferullo, J. (2013) Mortality and readmission of the elderly one year after hospitalization for pneumonia. Aging Clinical and Experimental Research, 16(1), 22-25. DOI: 10.1007/BF03324527
Hi Julie,Right off the bat I need to say YES YES YES! Your last post about aggression and what we can learn from and about it WITHOUT the need to experience it was spot on. Are you THIS attached to your dog? (source)You’re also right that my head is filled with glorious meta-analysis results right now, as well as perceptions and other measures (#allthemeasures!) as I start preparing my abstracts for submission to be part of the Canine Science Forum. One of the small but quirky things........ Read more »
Dwyer Fleur, Bennett Pauleen C., & Coleman Grahame J. (2006) Development of the Monash Dog Owner Relationship Scale (MDORS). Anthrozoos: A Multidisciplinary Journal of The Interactions of People , 19(3), 243-256. DOI: 10.2752/089279306785415592
Archer John, & Ireland Jane L. (2011) The Development and Factor Structure of a Questionnaire Measure of the Strength of Attachment to Pet Dogs. Anthrozoos: A Multidisciplinary Journal of The Interactions of People , 24(3), 249-261. DOI: 10.2752/175303711X13045914865060
Handlin Linda, Nilsson Anne, Ejdebäck Mikael, Hydbring-Sandberg Eva, & Uvnäs-Moberg Kerstin. (2012) Associations between the Psychological Characteristics of the Human–Dog Relationship and Oxytocin and Cortisol Levels. Anthrozoos: A Multidisciplinary Journal of The Interactions of People , 25(2), 215-228. DOI: 10.2752/175303712X13316289505468
We’ve written several articles on the apparent benefits of a higher protein diet for the older athlete. Loss of muscle mass starts fairly early and loss of strength is often apparent by middle age. We do not know how much protein intake is ideal for humans. High protein diets for older people have been geared […]The post High protein diet is protective for older people, but may be unhealthy for others appeared first on WODMasters.... Read more »
Levine, M., Suarez, J., Brandhorst, S., Balasubramanian, P., Cheng, C., Madia, F., Fontana, L., Mirisola, M., Guevara-Aguirre, J., Wan, J.... (2014) Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population. Cell Metabolism, 19(3), 407-417. DOI: 10.1016/j.cmet.2014.02.006
Gregorio L, Brindisi J, Kleppinger A, Sullivan R, Mangano KM, Bihuniak JD, Kenny AM, Kerstetter JE, & Insogna KL. (2014) Adequate Dietary Protein is Associated with Better Physical Performance among Post-Menopausal Women 60-90 Years. The journal of nutrition, health , 18(2), 155-60. PMID: 24522467
Beasley JM, Wertheim BC, LaCroix AZ, Prentice RL, Neuhouser ML, Tinker LF, Kritchevsky S, Shikany JM, Eaton C, Chen Z.... (2013) Biomarker-calibrated protein intake and physical function in the Women's Health Initiative. Journal of the American Geriatrics Society, 61(11), 1863-71. PMID: 24219187
Direct Access and the Six Month Dental recall: Taking decisions in uncertainty? This blog today is not about orthodontics, but it is about the interpretation of situations where there is a “lack of evidence” underpinning decisions. As a result, this is very relevant to all the clinical decisions that we may make in the face […]The post Direct Access and the six month dental recall: Taking decisions in uncertainty. appeared first on Kevin O'Brien's Orthodontic Blog.... Read more »
S. Turner,, S. Tripathee, & S. MacGillivray. (2013) Direct access to dental care professionals: what are the potential risks and benefits?. British Dental Journal, 577-582. DOI: 10.1038/sj.bdj.2013.1145
Riley P. (2013) Recall intervals for all health in primary care patients. Cochrane Library. DOI: 10.1002/14651858.CD004346.pub4
It all starts with a mosquito bite. When a hungry mosquito pierces someone’s skin to gorge herself, she also pumps …Continue reading →... Read more »
Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S, Rockett KA, Amaratunga C, Lim P, Suon S, Sreng S.... (2013) Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nature genetics, 45(6), 648-55. PMID: 23624527
We love gadgets in EMS.
Dr. Bryan Bledsoe tells us that if we paint it orange and put a star of life on it, we can sell any product for a lot more money.
How much would you pay to not improve outcomes?
$50,000.00?... Read more »
Rubertsson S, Lindgren E, Smekal D, Östlund O, Silfverstolpe J, Lichtveld RA, Boomars R, Ahlstedt B, Skoog G, Kastberg R.... (2014) Mechanical chest compressions and simultaneous defibrillation vs conventional cardiopulmonary resuscitation in out-of-hospital cardiac arrest: the LINC randomized trial. JAMA : the journal of the American Medical Association, 311(1), 53-61. PMID: 24240611
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