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  • December 1, 2014
  • 12:09 PM
  • 95 views

Common Genes in Neuropsychiatric Disorders

by William Yates, M.D. in Brain Posts

Finding a specific genes linked to specific neuropsychiatric disorders has been a key research strategy.However, this strategy has not been entirely successful.One problem with this unitary approach is the diagnostic overlap and comorbidity common to neuropsychiatric disorders such as mood disorders and autism.A promising alternative strategy is to focus on genes that share risk with more than one neuropsychiatric condition.Amit Lotan from Israel along with colleagues from the Netherlands, Germa........ Read more »

  • December 1, 2014
  • 09:56 AM
  • 94 views

How to improve children’s taste for healthy food?

by Usman Paracha in SayPeople

Main Point:

Don’t worry, if your children don’t like to eat fruits and vegetables. You have only to involve them in cooking or food preparation classes to increase their taste and willingness for these things.

Published in:

Preventing Chronic Disease: Public Health Research, Practice and Policy

Study Further:

Researchers are of opinion that exposing children to healthy foods is important. They have found that sending children to cooking classes or involving them in coo........ Read more »

  • December 1, 2014
  • 08:18 AM
  • 26 views

Two Surgeons Better Than One for Living Donor Nephrectomy

by Cristy at Living Donor 101 in Living Donors Are People Too

The authors found that a fixed (permanent, not rotating) surgical team comprised of two experienced* surgeons results in shorter operative time, lower estimated blood loss and shorter length of hospital stay for the living kidney donor. The study also found that proficient assistance (ie. non-surgeon personnel in the OR) is independently associated with those positive …
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The post Two Surgeons Better Than One for Living Donor Nephrectomy appeared first on Living Dono........ Read more »

Özdemir-van Brunschot, D., Warlé, M., van der Jagt, M., Grutters, J., van Horne, S., Kloke, H., van der Vliet, J., Langenhuijsen, J., & d’Ancona, F. (2014) Surgical team composition has a major impact on effectiveness and costs in laparoscopic donor nephrectomy. World Journal of Urology. DOI: 10.1007/s00345-014-1428-9  

  • December 1, 2014
  • 04:42 AM
  • 94 views

Cortisol and cytokines: a diagnostic tag-team for autism?

by Paul Whiteley in Questioning Answers

A quote from the paper by Chang-Jiang Yang and colleagues [1] begins today's post: "The results of ROC [receiver operating characteristic] analysis indicated the cortisol VAR, IL-6 and TNF-α were potential biomarkers in diagnosis of ASD [autism spectrum disorder]."With many thanks to Natasa for providing me with a copy of this paper, I'd like to discuss these 'joined up' findings a little further. A few pointers to begin with:Boot the grime of this world in the crotch, dearBased ........ Read more »

  • November 30, 2014
  • 01:31 PM
  • 123 views

Even more bad global warming news

by Gabriel in Lunatic Laboratories

While everyone (but seemingly the media) is on basically the same page with the fact that global warming is a human caused problem — and one we need to fix the effects of this change are still coming to light. Human-induced changes to Earth’s carbon cycle – for example, rising atmospheric carbon dioxide and ocean acidification – have been observed for decades. However, a new study showed human activities, in particular industrial and agricultural processes, have also had significant impa........ Read more »

Kim IN, Lee K, Gruber N, Karl DM, Bullister JL, Yang S, & Kim TW. (2014) Chemical oceanography. Increasing anthropogenic nitrogen in the North Pacific Ocean. Science (New York, N.Y.), 346(6213), 1102-6. PMID: 25430767  

  • November 29, 2014
  • 10:23 PM
  • 117 views

Global Warming Denial: What Does it Take? A Case Study of Climate Change Denialists

by Nick in How to Paint Your Panda

Despite the established scientific consensus on global climate change, a substantial number of people, specifically Americans, deny its effects or its taking place. Why does this form of denialism persist so feverishly? What can mitigate this gap between the scientific community and the public?... Read more »

Finucane, M., Slovic, P., Mertz, C., Flynn, J., & Satterfield, T. (2000) Gender, race, and perceived risk: The 'white male' effect. Health, Risk , 2(2), 159-172. DOI: 10.1080/713670162  

Hamilton, L., & Keim, B. (2009) Regional variation in perceptions about climate change. International Journal of Climatology, 29(15), 2348-2352. DOI: 10.1002/joc.1930  

Kahan, D., Peters, E., Wittlin, M., Slovic, P., Ouellette, L., Braman, D., & Mandel, G. (2012) The polarizing impact of science literacy and numeracy on perceived climate change risks. Nature Climate Change, 2(10), 732-735. DOI: 10.1038/nclimate1547  

  • November 29, 2014
  • 03:35 PM
  • 123 views

Vegetable oil in the fight against gastric disease

by Gabriel in Lunatic Laboratories

The bacterium Helicobacter pylori is strongly associated with gastric ulcers and cancer. Unfortunately, treating the bacteria with antibiotics is difficult and with the increase in antibiotic resistance it can be a dangerous fight to take on. Given the high rate of ulcers and stomach cancers, the need for a better treatment is becoming more apparent. New research may bring hope (and of all things) in the form of vegetable oil.
... Read more »

  • November 29, 2014
  • 03:40 AM
  • 114 views

This Month in Blastocystis Research (NOV 2014): Blasting Blastocystis Edition

by Christen Rune Stensvold in Blastocystis Parasite Blog

A few notes on deliberate and inadvertent attempts to eradicate Blastocystis.... Read more »

  • November 29, 2014
  • 03:30 AM
  • 113 views

NICE does increasing access to vitamin D supplements

by Paul Whiteley in Questioning Answers

If you happen to live in England or indeed other parts of the UK, you'll no doubt have heard about NICE - the National Institute for Health and Care Excellence - as the body charged with providing us with appropriate evidence-based guidance on all manner of treatments and technologies for all manner of different diagnoses and conditions. I've talked before on this blog about the NICE guidance in relation to the autism spectrum (see here for example).My name is Elisabeth Shaw, last survivor ........ Read more »

Lucas RM, Ponsonby AL, Dear K, Valery PC, Taylor B, van der Mei I, McMichael AJ, Pender MP, Chapman C, Coulthard A.... (2013) Vitamin D status: multifactorial contribution of environment, genes and other factors in healthy Australian adults across a latitude gradient. The Journal of steroid biochemistry and molecular biology, 300-8. PMID: 23395985  

  • November 28, 2014
  • 10:21 PM
  • 125 views

The Day After Thanksgiving

by Aurametrix team in Environmental health

Seasonal changes, holidays and shopping activities are among the environmental factors that can influence our health. What positive or negative effects can we expect on Black Friday and days right after? The Friday-after-Thanksgiving was coined "Black" by police officers because of the fact that the traffic on the day after Thanksgiving is usually heavy and crowds are large. And they were right. According to the National Highway Traffic Safety Administration & CDC, Thanksgiving is the most dang........ Read more »

Centers for Disease Control and Prevention (CDC). (2001) Reducing the risk for injury while traveling for Thanksgiving holidays. MMWR. Morbidity and mortality weekly report, 50(45), 1016-7. PMID: 11724161  

Hull HR, Radley D, Dinger MK, & Fields DA. (2006) The effect of the Thanksgiving holiday on weight gain. Nutrition journal, 29. PMID: 17118202  

Petrescu, M., & Murphy, M. (2013) Black Friday and Cyber Monday: a case study. International Journal of Electronic Marketing and Retailing, 5(3), 187. DOI: 10.1504/IJEMR.2013.052884  

  • November 28, 2014
  • 12:11 PM
  • 90 views

Packing on the Pounds: Let the Holiday Eating Season Begin

by Melissa Chernick in Science Storiented

Here in the U.S., yesterday was Thanksgiving. A time of family, thanks, and lots and lots of food. Be honest, how much did you eat yesterday? Me, I watched a lot of football while I ate appetizers followed by turkey with gravy, mashed potatoes, green bean casserole, cranberry sauce, and cake. Then I entered a food coma for a few hours. It was glorious.I typically approach a holiday with a journal article, but this time I am going to use the holiday as a jumping off point: Thanksgiving as the sta........ Read more »

  • November 28, 2014
  • 11:56 AM
  • 100 views

New discovery sheds light on the forming brain

by Gabriel in Lunatic Laboratories

The cerebral cortex, which controls higher processes such as perception, thought and cognition, is the most complex structure in the mammalian central nervous system. Although much is known about the intricate structure of this brain region, the processes governing its formation remain uncertain. Research has now uncovered how feedback between cells, as well as molecular factors, helps shape cortical development during mouse embryogenesis.... Read more »

  • November 28, 2014
  • 08:21 AM
  • 23 views

Measure Kidney Function Don’t Estimate It

by Cristy at Living Donor 101 in Living Donors Are People Too

  Because direct measurement of GFR is cumbersome, it is often estimated using serum creatinine clearance. Problem is, most folks must lose more than 50% of their kidney function before the SCr measures above normal. The goal, of course, of eGFR is to produce results as close to mGFR as possible.   So – the …
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The post Measure Kidney Function Don’t Estimate It appeared first on Living Donors Are People Too.
... Read more »

Bhuvanakrishna, T., Blake, G., Hilton, R., Burnapp, L., Sibley-Allen, C., & Goldsmith, D. (2014) Comparison of estimated GFR and measured GFR in prospective living kidney donors. International Urology and Nephrology. DOI: 10.1007/s11255-014-0859-y  

  • November 28, 2014
  • 02:34 AM
  • 101 views

The Autism-Spectrum Quotient: overlap between Asperger syndrome and schizophrenia

by Paul Whiteley in Questioning Answers

The paper by Tove Lugnegård and colleagues [1], including mention of one Maria Unenge Hallerbäck who has appeared on this blog previously, is fodder for today's discussions and their finding that a: "significant overlap of AQ [Autism-Spectrum Quotient] scores across the two diagnostic groups clearly reduces the discriminating power of the AQ in the separation of schizophrenia from AS [Asperger syndrome]."They say you're judged by the strength of your enemies.As per that link to ........ Read more »

  • November 27, 2014
  • 07:37 PM
  • 119 views

Does hot cocoa delay brain aging?

by Shelly Fan in Neurorexia

Image credits: downloaded from http://www.wallpapermania.eu/, artist unknown. One of the most enjoyable things about the holidays is curling up with a good book and a cup of...... Read more »

Brickman AM, Khan UA, Provenzano FA, Yeung LK, Suzuki W, Schroeter H, Wall M, Sloan RP, & Small SA. (2014) Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nature neuroscience, 17(12), 1798-803. PMID: 25344629  

  • November 27, 2014
  • 12:40 PM
  • 98 views

Fragile X and a new autism treatment

by Gabriel in Lunatic Laboratories

There are many roads to autism, none of them involve vaccination. I get tired of saying that, but it’s simple science, vaccines do not cause autism. Thankfully science knows this and is looking at not only what actually causes autism (Since again there are many different ways to develop on the spectrum). Well they may have found a new treatment for people affected by a common inherited form of autism by using a drug that is being tested as a treatment for cancer.... Read more »

Gkogkas, C., Khoutorsky, A., Cao, R., Jafarnejad, S., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T.... (2014) Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes. Cell Reports. DOI: 10.1016/j.celrep.2014.10.064  

  • November 27, 2014
  • 11:30 AM
  • 81 views

Potential New Roles for Bacteria and B Cells in Promoting the Stomach Flu

by Geoffrey Hannigan in Prophage

We are all unfortunately familiar with the notorious stomach flu. Most of us have experienced that awful nausea, vomiting, diarrhea, and tiredness associated with catching some stomach bug. While there are many viral causes of the stomach flu (also called gastroenteritis), one of the most common is the Norovirus. The Norovirus is a common and contagious virus that is currently the leading cause of viral gastroenteritis...... Read more »

Jones, M., Watanabe, M., Zhu, S., Graves, C., Keyes, L., Grau, K., Gonzalez-Hernandez, M., Iovine, N., Wobus, C., Vinje, J.... (2014) Enteric bacteria promote human and mouse norovirus infection of B cells. Science, 346(6210), 755-759. DOI: 10.1126/science.1257147  

  • November 27, 2014
  • 04:55 AM
  • 114 views

FC is a technique that has no validity

by Paul Whiteley in Questioning Answers

FC, by the way, refers to Facilitated Communication, a controversial technique which as the name suggests relies on a facilitator to support "the hand or arm of a communicatively impaired individual while using a keyboard or other devices with the aim of helping the individual to point and thereby to communicate." The quote for the title of this post comes from the paper by Ralf Schlosser and colleagues [1] who following systematic review, found "unequivocal evidence for facilitator co........ Read more »

Schlosser RW, Balandin S, Hemsley B, Iacono T, Probst P, & von Tetzchner S. (2014) Facilitated Communication and Authorship: A Systematic Review. Augmentative and alternative communication (Baltimore, Md. : 1985), 1-10. PMID: 25384895  

  • November 26, 2014
  • 03:20 PM
  • 142 views

Need to turn off the pain? Well now we can!

by Gabriel in Lunatic Laboratories

My sister suffers from chronic pain issues. I’ve written several posts about how her autoimmune disease is a special brand of pain that you will thankfully (almost certainly) never have to feel. While great strides have been made in pain management, there are still relatively few options that do not carry the risk of being extremely addictive. Well thankfully there is some new research and it offers hope, not just for my sister, but for the millions of people suffering from chronic pain that ........ Read more »

Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S.... (2014) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a journal of neurology. PMID: 25414036  

  • November 26, 2014
  • 11:06 AM
  • 121 views

Treatment Resistance in Eating Disorders

by William Yates, M.D. in Brain Posts

Clinicians treating patients with eating disorders find the challenge great with many treatment-resistant cases.To some extent, this is true of any clinical disorder. Outpatient treatment rolls and inpatient samples are over-represented by those failing to respond to initial interventions.A medical example is helpful here. Endocrinologists specializing in diabetes see more complicated cases where glucose control is difficult and diabetic complications are common.Diabetics with easy glucose contr........ Read more »

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