Macroautophagy, (heretofore referred to as autophagy) is thought to play a pivotal role in tumorigenesis and tumor cell survival. Autophagy is a self-degradative cellular process that recycles intracellular components such as proteins and lipids, and may also be used to clear extraneous or damaged organelles. Through this process, metabolites such as amino acids or fatty acids can be liberated for use by the cell. While basal levels of autophagy are required for cellular homeostasis, autophagy i........ Read more »
Martin Isabelle, Vincent I Poon, Zoe V Petropoulos, Samantha J Harder, Julian J Lum*. (2013) Exploring New Strategies to Monitor Autophagy and Related Cell Death Pathways Using Raman Spectroscopy. Journal of Cancer Research and Therapeutic Oncology, 1(1), 1-5. info:other/1:103
In my annual review of all things autism research covered on this blog, the accolade of paper of the year for 2013 went to [drum roll maestro]... that optimal outcome paper by Deborah Fein and colleagues* (see here and here for more information). Detailing the experiences of well-defined group of children previously diagnosed with an autism spectrum disorder (ASD) who no longer met the diagnostic criteria, the notions that (a) there may be differences in the developmental trajectories of childre........ Read more »
Anderson DK, Liang JW, & Lord C. (2013) Predicting young adult outcome among more and less cognitively able individuals with autism spectrum disorders. Journal of child psychology and psychiatry, and allied disciplines. PMID: 24313878
ErbB4 (HER4) is a member of the ErbB family of receptor tyrosine kinases, which includes the Epidermal Growth Factor Receptor (EGFR/ErbB1), ErbB2 (HER2/Neu), and ErbB3 (HER3). Mounting evidence indicates that ErbB4, unlike EGFR or ErbB2, functions as a tumor suppressor in many human malignancies. Previous analyses of the constitutively-dimerized and –active ErbB4 Q646C mutant indicate that ErbB4 kinase activity and phosphorylation of ErbB4 Tyr1056 are both required for the tumor suppressor........ Read more »
Richard M. Gallo#, Ianthe N. Bryant#, Christopher P. Mill, Steven Kaverman, David J. Riese II*. (2013) Multiple Functional Motifs Are Required for the Tumor Suppressor Activity of a Constitutively-Active ErbB4 Mutant. Journal of Cancer Research and Therapeutic Oncology, 1(1), 1-10. info:other/1:104
My post today is about state-of-the-art gene therapy that delivers genes straight to heart, where the genes activate proteins critical in restoring cardiac tissue in people affected by heart failure. The technique, developed at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai, is undergoing clinical trial.Cardiovascular disease is the leading cause of death worldwide. Heart failure--a condition by which the heart weakens and no longer pumps blood efficiently througho........ Read more »
Tilemann L, Lee A, Ishikawa K, Aguero J, Rapti K, Santos-Gallego C, Kohlbrenner E, Fish KM, Kho C, & Hajjar RJ. (2013) SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure. Science translational medicine, 5(211). PMID: 24225946
Yang L, & Xiao X. (2013) Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution. Virology journal, 50. PMID: 23394344
For those with their ear to the autism research ground, the paper by Roman Tyzio and colleagues  must have sounded like a freight train coming given the volume of headlines that have been generated from this research (see here for example). Circling around the neurotransmitter, GABA (as in GABA dabba doo!), their findings based on two mouse models of autism, or rather autism and Fragile X syndrome - including the very interesting prenatal valproate (VPA) exposure model - suggested "hippo........ Read more »
Tyzio R, Nardou R, Ferrari DC, Tsintsadze T, Shahrokhi A, Eftekhari S, Khalilov I, Tsintsadze V, Brouchoud C, Chazal G.... (2014) Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science (New York, N.Y.), 343(6171), 675-9. PMID: 24503856
As tobacco use is a worldwide public health problem, it is vital that all healthcare professionals be able to provide tobacco interventions for their patients. The purpose of this study was to survey Iranian health professions students to assess their tobacco knowledge, attitudes, behavior and practices
Results suggest that tobacco dependence education and cessation training should be enhanced in the health professions programs and tobacco use prevention communications should be aimed at colle........ Read more »
Laura M. Romito*, Farideh Kouchak, Amir Soofi, Shanila Fakheri, Mehrdad Askarian. (2013) Cigarette Smoking Knowledge, Attitudes, and Practices of Iranian Health Professions Students of Shiraz University of Medical Sciences, Shiraz, Iran- 2011. Journal of Dentistry , 1(1), 1-8. info:other/
Microscopy is a technique used in the lab to look at things that you can’t see with the naked eye. There are a number of different microscopes that have been developed to do this, but today I’m going to focus on fluorescence microscopy as that’s what I have experience using! It’s also (I think) pretty interesting.
This technique is actually really simple, and is based upon the principle that when you shine high energy light onto certain substances they will absorb an........ Read more »
Cowell IG, Tilby MJ, & Austin CA. (2011) An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay. Mutagenesis, 26(2), 253-60. PMID: 21068206
Endothelial Nitric Oxide (NO) synthase (eNOS)-produced NO plays a crucial role in maintaining vascular homeostasis. Bone marrow-derived circulating Endothelial Progenitor Cells (EPCs) recently emerged as an important marker of vascular health and contribute to endothelial repair after arterial injury.
BM-derived circulating EPCs are closely involved in eNOS-regulated endothelial repair and vascular function after arterial injury. This finding enriches our understandings of the important role ........ Read more »
Junlei Chang, Dmitriy N. Atochin, Qian Li, Karen S.L. Lam, Aimin Xu, Paul L. Huang*. (2013) Bone Marrow-Derived Circulating Endothelial Progenitor Cells Contribute to ENOS-Regulated Endothelial Repair and Vasodilation after Arterial Injury In Vivo. Journal of Cardiology and Vascular Medicine, 1(1), 1-8. info:other/
Anti-brain antibodies have been quite a recurrent theme in autism research circles over the past few years. I've covered research in this area a few times on this blog; primarily from the perspective of an intriguing bank of work looking at how the presence of circulating maternal auto-antibodies to foetal brain protein might heighten the risk of offspring autism (see here). If I also mention the words 'MAR autism' you can get a flavour as to how far this research has come, as well as the potent........ Read more »
Piras IS, Haapanen L, Napolioni V, Sacco R, Van de Water J, & Persico AM. (2014) Anti-brain antibodies are associated with more severe cognitive and behavioral profiles in Italian children with Autism Spectrum Disorder. Brain, behavior, and immunity. PMID: 24389156
Tobacco use has been correlated with increased HIV-1 infection. In vitro characterization of alveolar macrophages obtained from uninfected cigarette smokers showed an increased susceptibility to HIV-1 infection when compared with cell from non-smokers. We showed that Cigarette Smoke Condensate (CSC) enhances HIV-1 infection in primary CD4 cells. The underlying mechanisms of how CSC affects HIV-1 replication are unclear.
The traditional approach that studies the specific cellular processes th........ Read more »
Janaki Purushe, Mario PS Chin*. (2013) Identification of Cigarette Smoke Condensate-Modulated Hiv-1-Associated Host Factors Using A Targeted Transcriptomic Approach. Journal of HIV/AIDS , 1(1), 1-7. info:other/
Current drug treatments for cognitive impairment and dementia show limited effectiveness.Alternative adjunctive treatments in those with early cognitive impairment are needed.In a previous post, I outlined a review of what we know about exercise and cognition in elderly populations.An additional study is relevant to this topic and important.Takao Suzuki and colleagues in Japan conducted a randomized controlled trial of multicomponent exercise in older adults with evidence of mild cognitive impai........ Read more »
Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Ito K, Shimokata H, Washimi Y, Endo H, & Kato T. (2013) A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PloS one, 8(4). PMID: 23585901
SUMMARY: Chimæras have been in the news a lot recently. Also known as "halfsiders" or tetragametic chimæras, these unusual birds are actually two genetically distinct individuals -- twins -- fused into one being. This piece investigates how this biological accident occurs.... Read more »
Zhao D., McBride D., Nandi S., McQueen H. A., McGrew M. J., Hocking P. M., Lewis P. D., Sang H. M., & Clinton M. (2010) Somatic sex identity is cell autonomous in the chicken. Nature, 464(7286), 237-242. DOI: 10.1038/nature08852
Agate R. J., Grisham W., Wade J., Mann S., Wingfield J., Schanen C., Palotie A., & Arnold A. P. (2003) Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch. Proceedings of the National Academy of Sciences, 100(8), 4873-4878. DOI: 10.1073/pnas.0636925100
Arnold A. P. (2003) Minireview: Sex Chromosomes and Brain Sexual Differentiation. Endocrinology, 145(3), 1057-1062. DOI: 10.1210/en.2003-1491
Chue Justin, & Smith Craig A. (2011) Sex determination and sexual differentiation in the avian model. FEBS Journal, 278(7), 1027-1034. DOI: 10.1111/j.1742-4658.2011.08032.x
Macklin Madge Thurlow. (1923) A description of material from a gynandromorph fowl. Journal of Experimental Zoology, 38(3), 355-375. DOI: 10.1002/jez.1400380302
Johnson Phyllis T., & Otto Sara V. (1981) Histology of a Bilateral Gynandromorph of the Blue Crab, Callinectes sapidus Rathbun (Decapoda: Portunidae). Biological Bulletin, 161(2), 236. DOI: 10.2307/1540801
Boklage C. E. (2005) Embryogenesis of chimeras, twins and anterior midline asymmetries. Human Reproduction, 21(3), 579-591. DOI: 10.1093/humrep/dei370
The title of this post reflects the title of the paper by Marcia Datlow Smith and colleagues* which was given to me by Natasa (many thanks) a few days back. The paper is from 2012 so I don't think we can consider this a post about new research. Nevertheless the subject matter of the paper is potentially very important: "describing individuals with autism whose catastrophic illnesses were misdiagnosed due, at least partially, to their autism".@ WikipediaIt is indeed a pity that the Smith paper is........ Read more »
Marcia Datlow Smith, Patrick J. Graveline, & Jared Brian Smith. (2012) Autism and Obstacles to Medical Diagnosis and Treatment. Focus Autism Other Dev Disabl . DOI: 10.1177/1088357612450049
Superficial skin biopsies are common in dermatopathology specimens and can pose a diagnostic challenge especially in cosmetic sensitive areas such as the face.
When broadly transected so that the base of the lesion is not visualized, well-differentiated squamous cell carcinomas (SCC), hypertrophic actinic keratoses (HAK), irritated seborrheic keratoses (ISK), and verruca vulgaris (VV) can look quite similar on light microscopic examination.
Visit the following link for full text of the art........ Read more »
Kumaran Mudaliar , Kelli Hutchens,. (2013) Morphometric Image Analysis as a Tool in the Diagnosis of Transected Squamous Neoplasms. Journal of Clinical and Anatomic Pathology, 1(1), 1-5. info:other/
Achieving a healthy weight is a major goal of anorexia nervosa treatment. Indeed, a healthy weight is often seen as a prerequisite for psychological recovery. The fact that weight restoration is a crucial component of recovery is uncontroversial, the problem arises when it comes to determining what constitutes a healthy weight. How are ideal, optimal, or goal weights set? And who gets to decide?
Despite its recognized importance, there’s surprisingly little consensus on how target w........ Read more »
Roots, P., Hawker, J., & Gowers, S. (2006) The use of Target Weights in the Inpatient Treatment of Adolescent Anorexia Nervosa. European Eating Disorders Review, 323-328. DOI: 10.1002/erv.723
"I'm a labrador" does not = "I'm hungry" (source)Hey Julie,it's great to get an updated view of what's on the canine science cards for you in 2014 - looks like we're both going to be keeping busy - and wouldn't have it any other way!I can't believe we're already into February, to be honest. There are so many great new publications coming out, it's quite exciting to be able to share them with you here! You know I'm always thinking about the welfare of kennelled dogs (because PhD!) and I noticed a........ Read more »
Denham Hamish D.C., Bradshaw John W.S., & Rooney Nicola J. (2014) Repetitive behaviour in kennelled domestic dog: Stereotypical or not?. Physiology . DOI: 10.1016/j.physbeh.2014.01.007
DALLAIRE ANDRÉ. (1993) Stress and Behavior in Domestic Animals: Temperament as a Predisposing Factor to Stereotypies. Annals of the New York Academy of Sciences, 697(1 Corticotropin), 269-274. DOI: 10.1111/j.1749-6632.1993.tb49940.x
Ecthyma gangrenosum (EG) is a cutaneous lesion classically associated with potentially fatal pseudomonal septicemia in immunocompromised patients. Other bacterial and fungal pathogens have also been implicated in EG. Although EG typically occurs in neutropenic or immunocompromised patients, it can occasionally affect previously healthy children.
The cutaneous findings are characteristic with small indurated papulovesicles progressing rapidly to necrotic ulcers with surrounding erythema and a ce........ Read more »
Julianna J. Weiel, Cathryn Z. Zhang, Jessica A. Smith, Wei Wang, Jason DuPont, Fangru Lian*. (2013) Clinicopathologic Aspects of Ecthyma Gangrenosum in Pediatric Patients a Case Series and Review of the Literature. Journal of Clinical and Anatomic Pathology, 1(1), 1-5. info:other/
Next sensors will be in you, said a recent popular article. And some of them will monitor your digestive system.Accurate monitoring of digestion is hard. There are apps and high tech gadgets for that - like a fork that monitors eating speed or a watch that counts bites, but neither of them can provide a continuous and objective measures of what exactly is eaten and how it affects the digestive system.Thanks to wonders of modern technology, cows now have a device that can monitor the effects of f........ Read more »
Kiourti, Asimina. (2014) Implantable and ingestible medical devices with wireless telemetry functionalities: A review of current status and challenges. . Bioelectromagnetics, 35(1), 1-15. DOI: 10.1002/bem.21813
Hoskins, S.; Sobering, T.; Andresen, D.; Warren, S. (2009) Near-field wireless magnetic link for an ingestible cattle health monitoring pill. Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE . DOI: 10.1109/IEMBS.2009.5332812
This Month In Blastocystis Research is introducing the possible benefits of polyparasitism (!) and pulls out an example of a potentially protecting effect of Blastocystis.... Read more »
Franke MF, Del Castillo H, Pereda Y, Lecca L, Fuertes J, Cárdenas L, Becerra MC, Bayona J, & Murray M. (2013) Parasite Infection and Tuberculosis Disease among Children: A Case-Control Study. The American journal of tropical medicine and hygiene. PMID: 24379242
Archambaud C, Sismeiro O, Toedling J, Soubigou G, Bécavin C, Lechat P, Lebreton A, Ciaudo C, & Cossart P. (2013) The intestinal microbiota interferes with the microRNA response upon oral Listeria infection. mBio, 4(6). PMID: 24327339
Frosch AE, & John CC. (2012) Immunomodulation in Plasmodium falciparum malaria: experiments in nature and their conflicting implications for potential therapeutic agents. Expert review of anti-infective therapy, 10(11), 1343-56. PMID: 23241191
Poirier P, Meloni D, Nourrisson C, Wawrzyniak I, Viscogliosi E, Livrelli V, & Delbac F. (2014) Molecular subtyping of Blastocystis spp. using a new rDNA marker from the mitochondria-like organelle genome. Parasitology, 1-12. PMID: 24467909
Heger TJ, Edgcomb VP, Kim E, Lukeš J, Leander BS, & Yubuki N. (2013) A Resurgence in Field Research is Essential to Better Understand the Diversity, Ecology, and Evolution of Microbial Eukaryotes. The Journal of eukaryotic microbiology. PMID: 24325268
Righetti AA, Glinz D, Adiossan LG, Koua AY, Niamké S, Hurrell RF, Wegmüller R, N'Goran EK, & Utzinger J. (2012) Interactions and potential implications of Plasmodium falciparum-hookworm coinfection in different age groups in south-central Côte d'Ivoire. PLoS neglected tropical diseases, 6(11). PMID: 23133691
Over the next month, I will be focusing on the effects of exercise on the brain.This topic is important for several reasons. Exercise appears to play a preventive role in the effects of brain aging in normal adults.Exercise may aid in the slowing of progression of brain disorders such as Alzheimer's disease and Parkinson's disease.Exercise is a promising adjunct to treatment of a variety of other brain disorders including depression and anxiety disorder.For this post, I want to highlight wh........ Read more »
Erickson KI, Gildengers AG, & Butters MA. (2013) Physical activity and brain plasticity in late adulthood. Dialogues in clinical neuroscience, 15(1), 99-108. PMID: 23576893
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.