When you bring up the subject of listening to music while stoned, you get a range of responses, almost all of them positive. While you might enjoy a song in a non-altered state, under the influence of Cannabis, it has been established that listening to and creating music is somehow a deeper and more intense experience. The disputed issue that arises is why this happens and if the feeling is real.... Read more »
As consumers, we like to hear that produce growers and distributers go above and beyond food safety mandates to ensure that healthy fresh fruits and vegetables do not carry bacteria or viruses that can make us sick. But in California’s Salinas Valley, some more vigorous interventions are cutting into the last corners of wildlife habitat, without evidence of food safety benefits, creating tensions between wildlife preservation and food safety where none need exist.... Read more »
Sasha Gennet, Jeanette Howard, Jeff Langholz, Kathryn Andrews, Mark D Reynolds, & Scott A Morrison. (2013) Farm practices for food safety: an emerging threat to floodplain and riparian ecosystems. Frontiers in Ecology and the Environment, e-View ahead of print(May 6th). info:/10.1890/1202443
A lot has changed in the human body since our ancestors walked around on bare feet. We have less hair, we got bigger and we live longer, for example. But we’re still being haunted by some very stubborn diseases that survived the evolution. How is that possible?... Read more »
You’ve been hearing it for years; don’t eat too much sugar, because sugar rots your teeth. It turns out that sugar isn’t the real culprit behind tooth decay. Researchers, looking at the bacteria responsible for dental cavities, had found a molecule that can stop these common dental problems.
Jose Cordova, a Yale University researcher, and Erich Astudillo, from the University of Chile, identified the new molecule, called Keep32, that kills the Streptococcus Mutans bacteria an........ Read more »
Kind of a morbid question, but apparently one that is on many people’s minds. Suicide by drowning is definitely not impossible, although it is not the easiest method. Due to the body’s natural tendency to come up for air, drowning attempts are most likely to succeed in deep waters.... Read more »
Like Charlie Bucket looking through the sweet shop window at the delicious chocolates produced by the workforce of a certain Mr Willy Wonka (the candyman no less), I am always quite interested in the goings-on at the IMFAR autism research conference. The candyman can... @ Wikipedia This year (2013) proved to be a bit of a vintage, as once again the great and the good presented their Wonka bars of autism research; thus hinting at the direction of future autism research and what y........ Read more »
Höglund Carlsson, L., Norrelgen, F., Kjellmer, L., Westerlund, J., Gillberg, C., & Fernell, E. (2013) Coexisting Disorders and Problems in Preschool Children with Autism Spectrum Disorders. The Scientific World Journal, 1-6. DOI: 10.1155/2013/213979
We have differentiated between chromosomal versus hormonal influences on normal sleep and sleep rebounds in hermaphroditic mice. The neural mechanisms are TBD, however. ... Read more »
Ehlen, J., Hesse, S., Pinckney, L., & Paul, K. (2013) Sex Chromosomes Regulate Nighttime Sleep Propensity during Recovery from Sleep Loss in Mice. PLoS ONE, 8(5). DOI: 10.1371/journal.pone.0062205
A follow-up on Carl Zimmer's post in "Phenomena" (National Geographic) on 'Bugs as Drugs'.... Read more »
Hyman P, Atterbury R, & Barrow P. (2013) Fleas and smaller fleas: virotherapy for parasite infections. Trends in microbiology. PMID: 23540830
van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF, Tijssen JG.... (2013) Duodenal infusion of donor feces for recurrent Clostridium difficile. The New England journal of medicine, 368(5), 407-15. PMID: 23323867
Gray hair comes as a result of hydrogen peroxide accumulation in the hair follicles and the newly reported topical UVB-activated, pseudocatalase (PC-KUS) can help against the accumulation of hydrogen peroxide at the root level.
The FASEB Journal
"To date, it is beyond any doubt that the sudden loss of the inherited skin and localized hair color can affect those individuals in many fundamental ways," Karin U. Schallreuter, M.D., s........ Read more »
Schallreuter, K., Salem, M., Holtz, S., & Panske, A. (2013) Basic evidence for epidermal H2O2/ONOO--mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS. The FASEB Journal. DOI: 10.1096/fj.12-226779
Discussions on self-injurious behaviour (SIB) or auto-aggression are not normally for the faint-hearted.Indeed, as I intimated on a previous post on SIB and autism, when such behaviours are witnessed in children and young adults - even older adults, one does wonder what the effects might be not only on the person themselves but also on a parent or a sibling as they watch their own flesh and blood banging their head on a wall or pulling their hair out or trying to gouge their eyes out. I can't pu........ Read more »
Sisk RA, Motley WW 3rd, Yang MB, & West CE. (2013) Surgical outcomes following repair of traumatic retinal detachments in cognitively impaired adolescents with self-injurious behavior. Journal of pediatric ophthalmology and strabismus, 50(1), 20-6. PMID: 23061560
Did you ever take two or more antibiotics in order to get rid of a disease? New research in PLOS Biology suggests that this is not a wise thing to do. Drug resistant bacteria grow faster than their weaker counter parts when resources are limiting and many antibiotics are consumed.... Read more »
Pena-Miller R, Laehnemann D, Jansen G, Fuentes-Hernandez A, Rosenstiel P, Schulenburg H, & Beardmore R. (2013) When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition. PLoS biology, 11(4). PMID: 23630452
The benefits of taking fish oil and the harm caused by eating red meat, these two nutritional nuggets of wisdom have been passed around so much over the past few decades, we rarely stop to ask if they really do what people claim they do.
This month, two new papers on the subject of fish and meat have come forward from the University of Western Australia. The first examines the real impact of taking fish oil supplements on the diets of obese people.... Read more »
Wong, A., Chan, D., Ooi, E., Ng, T., Watts, G., & Barrett, P. (2013) Omega-3 fatty acid ethyl ester supplementation decreases very-low-density lipoprotein triacylglycerol secretion in obese men. Clinical Science, 125(1), 45-51. DOI: 10.1042/CS20120587
Koeth, R., Wang, Z., Levison, B., Buffa, J., Org, E., Sheehy, B., Britt, E., Fu, X., Wu, Y., Li, L.... (2013) Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine. DOI: 10.1038/nm.3145
Intravenous oxygen delivery that works?
Maybe temporary oxygenation, but not yet.
Will this change the approach to CICV (Can’t Intubate, Can’t Ventilate) patients?
No, but it may change the approach to CICO (Can’t Intubate, Can’t Oxygenate) patients.
The distinction is important. ... Read more »
Kheir, J., Scharp, L., Borden, M., Swanson, E., Loxley, A., Reese, J., Black, K., Velazquez, L., Thomson, L., Walsh, B.... (2012) Oxygen Gas-Filled Microparticles Provide Intravenous Oxygen Delivery. Science Translational Medicine, 4(140), 140-140. DOI: 10.1126/scitranslmed.3003679
The microbiome — the kilogram of microbes that each of us carries around — has been shown to be involved …Continue reading »... Read more »
Markle JG, Frank DN, Mortin-Toth S, Robertson CE, Feazel LM, Rolle-Kampczyk U, von Bergen M, McCoy KD, Macpherson AJ, & Danska JS. (2013) Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science (New York, N.Y.), 339(6123), 1084-8. PMID: 23328391
University of Florida researchers have developed a “DNA nanotrain” that fast-tracks its payload of cancer-fighting drugs and bioimaging agents to tumor cells deep within the body. The nanotrain’s ability to cost-effectively deliver high doses of drugs to precisely targeted cancers and other medical maladies without leaving behind toxic nano-clutter has been the elusive Holy Grail for scientists studying the teeny-tiny world of DNA nanotechnology.... Read more »
Lindy McCollum-Brounley. (2013) UF researchers develop ‘nanotrain’ for targeted cancer drug transport. University of Florida News. info:/
Components of Brain Limbic SystemAdvances in the diagnosis and treatment of brain disorders like bipolar disorder, schizophrenia and autism are a public health priority.Dr. Thomas Insel, director at NIMH recently presented a TED talk that emphasized the need to rethink how we conceptualize and study these types of disorders. He argues for a need to redefine mental disorders as brain disorders. Advances in brain research tools are likely to provide improvements in early diagnosis and ........ Read more »
Collins, P., Insel, T., Chockalingam, A., Daar, A., & Maddox, Y. (2013) Grand Challenges in Global Mental Health: Integration in Research, Policy, and Practice. PLoS Medicine, 10(4). DOI: 10.1371/journal.pmed.1001434
hypothesis: Use of recovery periods between weight sets can be used for vision work as form of active recovery to improve strength, vision and recovery technique. ... Read more »
Andersson H, Raastad T, Nilsson J, Paulsen G, Garthe I, & Kadi F. (2008) Neuromuscular fatigue and recovery in elite female soccer: effects of active recovery. Medicine and science in sports and exercise, 40(2), 372-80. PMID: 18202563
Davis WJ, Wood DT, Andrews RG, Elkind LM, & Davis WB. (2008) Elimination of delayed-onset muscle soreness by pre-resistance cardioacceleration before each set. Journal of strength and conditioning research / National Strength , 22(1), 212-25. PMID: 18296978
Micklewright, D., Beneke, R., Gladwell, V., & Sellens, M. (2003) BLOOD LACTATE REMOVAL USING COMBINED MASSAGE AND ACTIVE RECOVERY. Medicine , 35(Supplement 1). DOI: 10.1097/00005768-200305001-01755
Suzuki M, Umeda T, Nakaji S, Shimoyama T, Mashiko T, & Sugawara K. (2004) Effect of incorporating low intensity exercise into the recovery period after a rugby match. British journal of sports medicine, 38(4), 436-40. PMID: 15273179
It was an unprecedented move: U.S. Health and Human Services Secretary Kathleen Sibelius overruled the FDA when she announced that Teva Pharmaceutical’s Plan B One Step contraceptive pill would not be available to women under 17 years of age. ... Read more »
Funk RS, Brown JT, & Abdel-Rahman SM. (2012) Pediatric pharmacokinetics: human development and drug disposition. Pediatric clinics of North America, 59(5), 1001-16. PMID: 23036241
Researchers from the Wake Forest Baptist Medical Center (WFBMC) announced today that they may have unveiled some of the mechanisms involved in obesity, diabetes mellitus type 2, muscular dystrophy and other diseases associated with fat replacing muscle tissue, causing it to weaken and degenerate. Their findings have the potential to lead to new therapies for the aforementioned diseases, say the researchers.Read More... Read more »
Birbrair, A., Zhang, T., Wang, Z., Messi, M., Enikolopov, G., Mintz, A., & Delbono, O. (2013) Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation. Stem Cells and Development, 2147483647. DOI: 10.1089/scd.2012.0647
Globus Pallidus Region of Brain Targeted in DBS in YellowIn a previous post, I summarized some of the highlights of a recent review of Parkinson's disease management by the German neurologists Pedrosa and Timmerman.The first post can be located here and was limited to the drug treatment of the motor symptoms of Parkinson's disease.In part II, I want to focus on deep brain stimulation and the treatment of non-motor symptoms.The authors of the review note the following key points regarding deep br........ Read more »
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