We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »
Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215
That is the recipe for depression. Chronic Mild Stress (CMS). Or at least it is the recipe I used to depress rats. As I mentioned earlier I worked with rats to research the mood-effects of Salvia. One important piece of this research was the idea that a depressed brain is different than a healthy brain and may respond differently to drug exposure. So in order to apply that in rats, I needed a way to create depressed rats. For me, that meant using CMS.
... Read more »
Katz, R. (1982) Animal model of depression: Pharmacological sensitivity of a hedonic deficit. Pharmacology Biochemistry and Behavior, 16(6), 965-968. DOI: 10.1016/0091-3057(82)90053-3
Willner, P. (2005) Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS. Neuropsychobiology, 52(2), 90-110. DOI: 10.1159/000087097
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